Marianela Schiava, Robert Muni Lofra, John P Bourke, Jordi Díaz-Manera, Meredith K James, Maha A Elseed, Monika Malinova, Jassi Michel-Sodhi, Dionne Moat, Elisabetta Ghimenton, Michelle Mccallum, Carla Florencia Bolaño Díaz, Anna Mayhew, Karen Wong, Mark Richardson, Giorgio Tasca, Gail Eglon, Michelle Eagle, Cathy Turner, Emma Heslop, Volker Straub, Chiara Marini Bettolo, Michela Guglieri
BACKGROUND AND PURPOSE: The transition to adult services, and subsequent glucocorticoid management, is critical in adults with Duchenne muscular dystrophy. This study aims (1) to describe treatment, functional abilities, respiratory and cardiac status during transition to adulthood and adult stages; and (2) to explore the association between glucocorticoid treatment after loss of ambulation (LOA) and late-stage clinical outcomes. METHODS: This was a retrospective single-centre study on individuals with Duchenne muscular dystrophy (≥16 years old) between 1986 and 2022...
March 31, 2024: European Journal of Neurology