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Olalla Santa Cruz, Pelagia Tsoutsou, Cyril Castella, Kaouthar Khanfir, Sandro Anchisi, Salim Bouayed, Oscar Matzinger, Mahmut Ozsahin
OBJECTIVES: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%)...
June 12, 2018: Oncology
E Incerti, S Broggi, A Fodor, M Cuzzocrea, A M Samanes Gajate, P Mapelli, C Fiorino, I Dell'Oca, M Pasetti, M Cattaneo, R Calandrino, L Gianolli, N Di Muzio, Maria Picchio
PURPOSE: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. METHODS: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max ), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%)...
June 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Hidetoshi Shimizu, Koji Sasaki, Takashi Kubota, Hiroshi Fukuma, Takahiro Aoyama, Tohru Iwata, Hiroyuki Tachibana, Takeshi Kodaira
Several studies have reported changes in dose distribution and delivery time based on the value of specific planning parameters [field width (FW), pitch, and modulation factor (MF)] in tomotherapy. However, the variation in the parameters between different facilities is unknown. The purpose of this study was to determine standard values of the above parameters for cases of head and neck cancer (HNC) and prostate cancer (PC) in Japan. In this survey, a web-based questionnaire was sent to 48 facilities performing radiation therapy with tomotherapy in March 2016...
June 2, 2018: Journal of Radiation Research
Ke Zhang, Jianrong Dai, Zhihui Hu, Chuanmeng Niu
PURPOSE: To investigate the dosimetric impact of hysteresis on lung cancer tomotherapy. METHODS: Measurements were acquired using MapCheck with an XY4D motion simulation table. Six hysteresis states (0, π/32, π/16, π/8, 3π/16, and π/4) were considered with sinusoidal motions in the superior-inferior and left-right orientations. The measured data were analyzed both globally (from all detectors) and structure-by-structure in the measurement plane. The dose difference (DD) analysis method with local normalization in the absolute dose mode with a DD threshold of 6 cGy was adopted to analyze each hysteresis vs...
May 2018: Physica Medica: PM
Alexandre Arsene-Henry, Jean-Philippe Foy, Magalie Robilliard, Hao-Ping Xu, Louis Bazire, Dominique Peurien, Philip Poortmans, Alain Fourquet, Youlia M Kirova
Purpose: to evaluate our experience in terms of local control, survival, adverse effects in patients treated by adjuvant helical tomotherapy (HT) for breast cancer (BC). Results: We studied 179 consecutive patients with 194 treated breasts with adjuvant HT. Median follow-up was 38.1 months. Median age was 53 years. Chemotherapy was administered to 83% of patients. All 133 hormone receptor positive tumours received hormonal therapy. As concurrent treatment, apart from trastuzumab monotherapy, 6 patients received systemic therapy concomitant to RT...
May 4, 2018: Oncotarget
Pierpaolo Alongi, Leonardo Iaccarino, Marco Losa, Antonella Del Vecchio, Simonetta Gerevini, Valentina Plebani, Nadia Di Muzio, Pietro Mortini, Luigi Gianolli, Daniela Perani
BACKGROUND AND OBJECTIVE: Even though the benefits of radiation therapy are well established, it is important to recognize the broad spectrum of radiation-induced changes, particularly in the central nervous system. The possible damage to the brain parenchyma may have clinical consequences and in particular cognitive impairment might be one of the major complication of radiotherapy. To date, no studies have investigated the effects of focal radiation therapy on brain structure and function together with the assessment of their clinical outcomes at a long follow-up...
May 25, 2018: Current Radiopharmaceuticals
Sun Zong-Wen, Yang Shuang-Yan, Du Feng-Lei, Cheng Xiao-Long, Li Qinglin, Chen Meng-Yuan, Hua Yong-Hong, Jin Ting, Hu Qiao-Ying, Chen Xiao-Zhong, Chen Yuan-Yuan, Chen Ming
Introduction: All adult medulloblastoma (AMB) patients should be treated with craniospinal irradiation (CSI) postoperatively. Because of the long irradiation range, multiple radiation fields must be designed for conventional radiotherapy technology. CSI can be completed in only one session with helical tomotherapy (HT). We evaluated the dose of HT, volumetric intensity modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3D-CRT) of AMB and the results of 5 cases of AMB treated with HT...
2018: BioMed Research International
Hannah M Laidley, David J Noble, Gill C Barnett, Julia R Forman, Amy M Bates, Richard J Benson, Sarah J Jefferies, Rajesh Jena, Neil G Burnet
BACKGROUND: L'Hermitte's sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high. METHODS: One hundred seventeen patients treated with TomoTherapy™ between 2008 and 2015 prospectively completed a side-effect questionnaire (VoxTox Trial Registration: UK CRN ID 13716). Baseline patient and treatment data were collected. Radiotherapy plans were analysed; mean and maximum spinal cord dose and volumes receiving 10, 20, 30 and 40 Gy were recorded...
May 4, 2018: Radiation Oncology
Makoto Hirata, Hajime Monzen, Mikoto Tamura, Kazuki Kubo, Kenji Matsumoto, Kohei Hanaoka, Masahiko Okumura, Yasumasa Nishimura
BACKGROUND/AIM: Patient immobilization systems are used to establish a reproducible patient position relative to the couch. In this study, the impact of conventional lok-bars for CT-simulation (CIVCO-bar) and treatment (iBEAM-bar) were compared with a novel lok-bar (mHM-bar) in tomotherapy. MATERIALS AND METHODS: Verification was obtained as follows: i. artifacts in CT images; ii. dose attenuation rate of lok-bar, compared to without lok-bar; and iii. dose differences between the calculated and measured absorbed doses...
May 2018: Anticancer Research
Chi-Him Li, Vincent Wc Wu, George Chiu
OBJECTIVE: In radiotherapy of nasopharyngeal carcinoma (NPC) patients, the brachial plexus (BP) situated at both sides of the neck is often irradiated to high dose. This study was to evaluate different BP delineation methods and analyse the dosimetric consequences when applying BP dose constraints in radiotherapy planning of NPC. METHODS: 15 NPC cases radically treated with helical tomotherapy were recruited. Apart from the original treatment plan (Plan A), two new plans (Plans B and C) with additional BP dose constraints were computed using the same planning CT images, structures and planning parameters...
May 17, 2018: British Journal of Radiology
Hector Rene Vega-Carrillo, Angelica Esparza-Hernandez, Mayra G Garcia-Reyna, Eric Reyes Rivera, Luis Hernandez-Adame, Teodoro Rivera
The ambient dose equivalent has been measured on the walls of a bunker with a 6 MV TomoLINAC, which was designed to have a conventional 18 MV LINAC. The ambient dose equivalent is due to scattered photons on patient bodies during cancer treatment. Measurements were carried out with thermoluminescent dosimeters that were fixed, at the isocentre plane, on the primary and secondary barriers, the maze, and on the TomoLINAC surface. Measurements were repeated three times, in each time dosimeters were on place during seven working days, where approximately 50 patients were treated per day...
April 6, 2018: Applied Radiation and Isotopes
Jian Zhu, Tong Bai, Jiabing Gu, Ziwen Sun, Yumei Wei, Baosheng Li, Yong Yin
BACKGROUND: To evaluate the effect of pretreatment megavoltage computed tomographic (MVCT) scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy. METHODS: Both anthropomorphic heterogeneous chest and pelvic phantoms were planned with virtual targets by TomoTherapy Physicist Station and were scanned with TomoTherapy megavoltage image-guided radiotherapy (IGRT) system consisted of six groups of options: three different acquisition pitches (APs) of 'fine', 'normal' and 'coarse' were implemented by multiplying 2 different corresponding reconstruction intervals (RIs)...
April 27, 2018: Radiation Oncology
Enrica Seravalli, Mirjam Bosman, Yasmin Lassen-Ramshad, Anne Vestergaard, Foppe Oldenburger, Jorrit Visser, Efi Koutsouveli, Chryssa Paraskevopoulou, Gail Horan, Thankamma Ajithkumar, Beate Timmermann, Carolina-Sofia Fuentes, Gillian Whitfield, Thomas Marchant, Laetitia Padovani, Eloise Garnier, Lorenza Gandola, Silvia Meroni, Bianca A W Hoeben, Martijn Kusters, Claire Alapetite, Sandra Losa, Farid Goudjil, Henriette Magelssen, Morten Egeberg Evensen, Frank Saran, Gregory Smyth, Barbara Rombi, Roberto Righetto, Rolf-Dieter Kortmann, Geert O Janssens
PURPOSE: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy® , proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. MATERIAL AND METHODS: A multicenter (n = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy® , PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36...
April 26, 2018: Acta Oncologica
Eric Grignano, Jérémy Laurent, Bénédicte Deau, Barbara Burroni, Didier Bouscary, Youlia M Kirova
OBJECTIVE: Many salvage therapies have been proposed for relapsed/refractory (R/R) diffuse large B-cell lymphomas or for consolidation in the case of suboptimal response. Radiotherapy (RT) is one modality of salvage therapy, but its place is currently not well defined. METHOD: This study reports a retrospective review of patients receiving unplanned radiotherapy for R/R diffuse large B-cell lymphoma (DLBCL) or primary mediastinal B-cell lymphoma (PMBCL), or as consolidation therapy after second-line chemotherapy, treated in our hospital...
April 16, 2018: European Journal of Haematology
Dayna Bodensteiner
RaySearch Laboratories is a world leader in the field of advanced software and creator of the RayStation treatment planning system for radiation therapy. The aim with RayStation is to deliver an unmatched user experience and leading functionality. Unique features described here include multiatlas based autosegmentation for contouring, deformable registration with 2 different algorithms, multicriteria optimization, Plan Explorer, fallback planning, ultrafast computation speed, and 4-dimensional (4D) adaptive radiation therapy...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
Jeong Il Yu, DO Hoon Lim, Hee Chul Park, Sang Hoon Jung, Seong Jin Jeon, Heerim Nam, Bokyoung Kim, Sung-Joo Kim, Jae Berm Park
BACKGROUND/AIM: We investigated the effectiveness and safety of using a tissue expander (TE) for adjuvant helical tomotherapy (HT) for curatively resected retroperitoneal sarcoma (RPS). MATERIALS AND METHODS: This study was conducted with 60 RPS patients who underwent curative resection with or without TE insertion followed by HT from June 2009 to December 2016. Among the patients, TE was inserted in 37 (61.7%). The quality of TE insertion was evaluated. Median follow-up after surgery was 19...
April 2018: Anticancer Research
Cheng B Saw, Leah Katz, Carol Gillette, Lawrence Koutcher
The helical tomotherapy is a technologically advanced radiation dose delivery system designed to perform intensity-modulated radiation therapy (IMRT). It is mechanistically unique, based on a small 6-MV linear accelerator mounted on a ring gantry that rotates around the patient while the patient moves through a bore, ultimately yielding a helical path of radiation dose delivery. The helical pattern of dose delivery differentiated tomotherapy from other contemporary radiation therapy systems at the time of its inception...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Yao-Ching Wang, Chia-Chin Li, Chun-Ru Chien
OBJECTIVE: This study used a population-based propensity score (PS)-matched analysis to compare the effectiveness of tomotherapy-based image-guided intensity-modulated radiotherapy (referred to as T-IMRT) with that of linear accelerator based (referred to as L-IMRT) for clinically localized pharyngeal cancer (LPC, divided into nasopharyngeal cancer and non-nasopharyngeal cancer) with definitive concurrent chemoradiotherapy (CCRT). METHODS: Eligible LPC patients diagnosed between 2007 and 2014 were identified among all citizens in Taiwan from the Health and Welfare Data Science Center database...
May 17, 2018: British Journal of Radiology
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