keyword
https://read.qxmd.com/read/38434911/curative-radiotherapy-for-oropharyngeal-squamous-cell-carcinoma-stratified-by-p16-status-according-to-the-eighth-edition-american-joint-committee-on-cancer-staging-manual-a-retrospective-study
#1
JOURNAL ARTICLE
Atsuto Katano, Masanari Minamitani, Shingo Ohira, Hideomi Yamashita
BACKGROUND/AIM: The prevalence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing worldwide. This retrospective study aimed to investigate the clinical outcomes of patients with OPSCC undergoing definitive radiotherapy, stratified according to their p16 status. PATIENTS AND METHODS: A retrospective analysis was conducted on consecutive patients with OPSCC treated with curative external beam radiotherapy between May 2015 and September 2023. Clinical staging was determined by the eighth edition AJCC staging manual for p16 positive and negative OPSCC...
2024: Cancer Diagn Progn
https://read.qxmd.com/read/38368607/dosimetric-evaluation-in-helical-tomotherapy-for-lung-sbrt-using-monte-carlo-based-independent-dose-verification-software
#2
JOURNAL ARTICLE
Takahiro Kosaka, Jun Takatsu, Tatsuya Inoue, Kotaro Iijima, Michimasa Suzuki, Naoya Murakami, Naoto Shikama
PURPOSE: To elucidate the dosimetric errors caused by a model-based algorithm in lung stereotactic body radiation therapy (SBRT) with Helical TomoTherapy (HT) using Monte Carlo (MC)-based dose verification software. METHODS: For 38 plans of lung SBRT, the dose calculation accuracy of a treatment planning system (TPS) of HT was compared with the results of DoseCHECK, the commercial MC-based independent verification software. The following indices were extracted to evaluate the correlation of dosimetric errors: (1) target volume, (2) average computed tomography (CT) value of the planning target volume (PTV) margin, and (3) average CT value of surrounding 2-mm area of the PTV (PTV ring)...
February 18, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38334889/the-effects-of-mega-voltage-ct-scan-parameters-on-offline-adaptive-radiation-therapy
#3
JOURNAL ARTICLE
Kento Hoshida, Ayumu Ohishi, Asumi Mizoguchi, Sunao Ohkura, Hidemichi Kawata
TomoTherapy involves image-guided radiation therapy (IGRT) using Mega-voltage CT (MVCT) for each treatment session. The acquired MVCT images can be utilized for the retrospective assessment of dose distribution. The TomoTherapy provides 18 distinct imaging conditions that can be selected based on a combination of algorithms, acquisition pitch, and slice interval. We investigated the accuracy of dose calculation and deformable image registration (DIR) depending on MVCT scan parameters and their effects on adaptive radiation therapy (ART)...
March 2024: Radiological Physics and Technology
https://read.qxmd.com/read/38318170/early-allogeneic-immune-modulation-after-establishment-of-donor-hematopoietic-cell-induced-mixed-chimerism-in-a-nonhuman-primate-kidney-transplant-model
#4
JOURNAL ARTICLE
Christopher J Little, Steven C Kim, John H Fechner, Jen Post, Jennifer Coonen, Peter Chlebeck, Max Winslow, Dennis Kobuzi, Samuel Strober, Dixon B Kaufman
BACKGROUND: Mixed lymphohematopoietic chimerism is a proven strategy for achieving operational transplant tolerance, though the underlying immunologic mechanisms are incompletely understood. METHODS: A post-transplant, non-myeloablative, tomotherapy-based total lymphoid (TLI) irradiation protocol combined with anti-thymocyte globulin and T cell co-stimulatory blockade (belatacept) induction was applied to a 3-5 MHC antigen mismatched rhesus macaque kidney and hematopoietic cell transplant model...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38274723/clinical-outcomes-of-curative-intent-radiotherapy-by-helical-tomotherapy-for-laryngeal-squamous-cell-carcinoma-a-retrospective-analysis-in-a-tertiary-referral-center
#5
JOURNAL ARTICLE
Atsuto Katano, Hideomi Yamashita
BACKGROUND: The management of laryngeal cancer involves balancing curative treatment with preserving essential functions. This study aimed to evaluate the clinical outcomes of helical tomotherapy, an advanced form of radiation therapy, as a primary treatment modality for laryngeal squamous cell carcinoma (LSCC). METHODS: A retrospective analysis of data obtained from a tertiary referral center was performed to assess treatment response rates, survival outcomes, disease control, and treatment-related adverse events...
February 2024: World Journal of Oncology
https://read.qxmd.com/read/38265521/evaluation-of-robustness-of-optimization-methods-in-breast-intensity-modulated-radiation-therapy-using-tomotherapy
#6
JOURNAL ARTICLE
Yuya Oki, Hiroaki Akasaka, Kazuyuki Uehara, Kazufusa Mizonobe, Masanobu Sawada, Junya Nagata, Aya Harada, Hiroshi Mayahara
Intensity-modulated radiation therapy (IMRT) has become a popular choice for breast cancer treatment. We aimed to evaluate and compare the robustness of each optimization method used for breast IMRT using TomoTherapy. A retrospective analysis was performed on 10 patients with left breast cancer. For each optimization method (clipping, virtual bolus, and skin flash), a corresponding 50 Gy/25 fr plan was created in the helical and direct TomoTherapy modes. The dose-volume histogram parameters were compared after shifting the patients anteriorly and posteriorly...
January 24, 2024: Physical and engineering sciences in medicine
https://read.qxmd.com/read/38200626/editorial-comment-on-does-intensity-modulated-radiation-therapy-by-helical-tomotherapy-for-prostate-cancer-increase-the-subsequent-risk-of-bladder-cancer-a%C3%A2-propensity-score-matched-analysis
#7
JOURNAL ARTICLE
Osamu Ukimura
No abstract text is available yet for this article.
January 10, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38195438/adjuvant-medial-versus-entire-supraclavicular-lymph-node-irradiation-in-high-risk-early-breast-cancer-suclanode-a-protocol-for-a-multicenter-randomized-open-label-phase-3-trial
#8
JOURNAL ARTICLE
Li Zhang, Xin Mei, Zhigang Hu, Bo Yu, Chaoyang Zhang, Yong Li, Kaitai Liu, Xuejun Ma, Jinli Ma, Xingxing Chen, Jin Meng, Wei Shi, Xiaofang Wang, Miao Mo, Zhimin Shao, Zhen Zhang, Xiaoli Yu, Xiaomao Guo, Zhaozhi Yang
BACKGROUND: Supraclavicular nodal (SCL) irradiation is commonly used for patients with high-risk breast cancer after breast surgery. The Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast contouring atlases delineate the medial part of the SCL region, while excluding the posterolateral part. However, recent studies have found that a substantial proportion of SCL failures are located in the posterolateral SCL region, outside of the RTOG/ESTRO-defined SCL target volumes...
January 9, 2024: BMC Cancer
https://read.qxmd.com/read/38194100/dosimetric-and-radiobiological-comparison-of-imrt-vmat-and-helical-tomotherapy-planning-techniques-in-hippocampal-sparing-whole-brain-radiotherapy-with-simultaneous-integrated-boost-for-multiple-brain-metastases
#9
JOURNAL ARTICLE
S Balasubramanian, M K Shobana, D Anabalagan, P Thanasekar, S Joel, Prekshi Chaudhary
To compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques. In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30 Gy and 36 Gy was delivered in 10 fractions for WBRT and SIB, respectively...
January 9, 2024: Radiation and Environmental Biophysics
https://read.qxmd.com/read/38193565/does-intensity-modulated-radiation-therapy-by-helical-tomotherapy-for-prostate-cancer-increase-the-subsequent-risk-of-bladder-cancer-a-propensity-score-matched-analysis
#10
JOURNAL ARTICLE
Fumio Tsukuda, Yasunari Tanaka, Shuichiro Narita, Toshihiro Shimizu, Shu Nakasuka, Kiichi Hagiwara, Noboru Sakamoto, Kawano Toshihiro, Yutaka Horiguchi, Shoji Koga
OBJECTIVES: This study aimed to evaluate the risk of bladder cancer after intensity-modulated radiation therapy (IMRT) using helical tomotherapy for prostate cancer in comparison to the risk post-radical prostatectomy (RP) using propensity score-matched analysis and to assess the risk factors for bladder cancer. METHODS: This retrospective study included 2067 patients with non-metastatic prostate cancer treated at our institution between June 2007 and December 2016...
January 9, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38182553/hippocampal-region-avoidance-in-whole-brain-radiotherapy-in-brain-metastases-for-all-or-for-some-a-real-world-feasibility-report
#11
JOURNAL ARTICLE
Giulia Corrao, Luca Bergamaschi, Vanessa Eleonora Pierini, Aurora Gaeta, Stefania Volpe, Matteo Pepa, Mattia Zaffaroni, Maria Giulia Vincini, Cristiana Iuliana Fodor, Gaia Piperno, Francesca Emiro, Annamaria Ferrari, Sara Gandini, Federica Cattani, Roberto Orecchia, Giulia Marvaso, Barbara Alicja Jereczek-Fossa
PURPOSE: Hippocampal sparing whole-brain radiotherapy (HS-WBRT) showed significantly lower long-term side effects compared to standard WBRT. Aim of this study is to describe a HS-WBRT real-world monoinstitutional experience within a retrospective cohort. METHODS: Patients who completed HS-WBRT course, with Karnofsky Performance Status ⩾ 60 and radiological diagnosis of brain metastases (BMs) were enrolled. Treatment was performed using helical Tomotherapy scheduled in 30 Gy in 10 or 12 fractions or 25 Gy in 10 fractions...
February 2024: Tumori
https://read.qxmd.com/read/38148099/comparing-efficacy-between-robust-and-ptv-margin-based-optimizations-for-interfractional-anatomical-variations-in-prostate-tomotherapy
#12
JOURNAL ARTICLE
Takayuki Yagihashi, Tatsuya Inoue, Shintaro Shiba, Akihiro Yamano, Masashi Yamanaka, Naoki Sato, Kazumasa Inoue, Motoko Omura, Hironori Nagata
BACKGROUND/AIM: Interfractional anatomical variations cause considerable differences between planned and actual radiotherapy doses. This study aimed to investigate the efficacy of robust and planning target volume (PTV) margin-based optimizations for the anatomical variations in helical tomotherapy for prostate cancer. PATIENTS AND METHODS: Ten patients underwent treatment-planning kilovolt computed tomography (kVCT) and daily megavolt computed tomography (MVCT)...
2024: In Vivo
https://read.qxmd.com/read/38140755/investigation-on-the-accuracy-of-field-widths-and-the-quantitative-relationship-with-energy-variations-for-dynamic-jaws-helical-tomotherapy
#13
JOURNAL ARTICLE
Ho Ming Poon, Tin Lok Chiu, Siu Ki Yu
BACKGROUND AND PURPOSE: TomoEDGE is an advanced technology for TomoTherapy treatment delivery by introducing a sliding-window dynamic jaw motion. The front and back jaws move independently at the start and end of a target volume along the longitudinal couch direction to reduce the undesired dose to the normal tissues. The accuracy of field width is essential to treatment delivery in this regard. The purpose of this work was to analyze the performance of dynamic jaws on helical tomotherapy and investigate the relationship with energy variation...
December 22, 2023: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38112216/ct-number-calibration-audit-in-photon-radiation-therapy
#14
JOURNAL ARTICLE
Minoru Nakao, Shuichi Ozawa, Hideharu Miura, Kiyoshi Yamada, Masahiro Hayata, Kosuke Hayashi, Daisuke Kawahara, Takeo Nakashima, Yusuke Ochi, Takuro Okumura, Haruhide Kunimoto, Atsushi Kawakubo, Hayate Kusaba, Hiroshige Nozaki, Kosaku Habara, Naoki Tohyama, Teiji Nishio, Mitsuhiro Nakamura, Toshiyuki Minemura, Hiroyuki Okamoto, Masayori Ishikawa, Masahiko Kurooka, Hidetoshi Shimizu, Kenji Hotta, Masahide Saito, Masahiro Nakano, Masato Tsuneda, Yasushi Nagata
BACKGROUND: Inadequate computed tomography (CT) number calibration curves affect dose calculation accuracy. Although CT number calibration curves registered in treatment planning systems (TPSs) should be consistent with human tissues, it is unclear whether adequate CT number calibration is performed because CT number calibration curves have not been assessed for various types of CT number calibration phantoms and TPSs. PURPOSE: The purpose of this study was to investigate CT number calibration curves for mass density (ρ) and relative electron density (ρe )...
December 19, 2023: Medical Physics
https://read.qxmd.com/read/38101995/whole-brain-radiotherapy-with-hippocampus-sparing-and-simultaneous-integrated-boost-to-metastases-a-plan-quality-comparison-study-between-ethos-hyperarc-vmat-and-tomotherapy
#15
JOURNAL ARTICLE
Yucel Akdeniz, Burcin Ispir
This study provides a concise and structured overview of a dosimetric comparison study conducted to assess the feasibility and effectiveness of 4 advanced radiotherapy techniques in treating brain metastases with hippocampus sparing and simultaneous integrated boost (HS-WBRT+SIB). Eleven patients with brain metastases previously treated with radiotherapy were included in the study. Planning CT scans with 2 mm slice thickness and MR imaging were used for contouring and dose prescription. The bilateral hippocampus and other organs at risk (OARs) were automatically contoured, and hippocampal avoidance regions (HAR) were defined as a 7 mm 3D expansion around the hippocampus...
December 14, 2023: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://read.qxmd.com/read/38071746/a-digital-male-pelvis-phantom-series-showing-anatomical-variations-over-the-course-of-fractionated-radiotherapy-treatment
#16
JOURNAL ARTICLE
Bruce Faddegon, Martina Descovich, Katherine Chen, José Ramos-Méndez, Mack Roach Iii, Niklas Wahl, Paige Taylor, Keith Griffin, Choonsik Lee
BACKGROUND: Daily IGRT images show day-to-day anatomical variations in patients undergoing fractionated prostate radiotherapy. This is of particular importance in particle beam treatments. PURPOSE: To develop a digital phantom series showing variation in pelvic anatomy for evaluating treatment planning and IGRT procedures in particle radiotherapy. METHODS: A pelvic phantom series was developed from the planning MRI and kVCT (planning CT) images along with six of the daily serial MVCT images taken of a single patient treated with a full bladder on a Tomotherapy unit...
December 10, 2023: Medical Physics
https://read.qxmd.com/read/38055371/comparison-of-volumetric-modulated-arc-therapy-and-helical-tomotherapy-for-prostate-cancer-using-pareto-fronts
#17
JOURNAL ARTICLE
Diana Wüthrich, Zirun Wang, Michele Zeverino, Jean Bourhis, François Bochud, Raphaël Moeckli
BACKGROUND: Studies comparing different radiotherapy treatment techniques-such as volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT)-typically compare one treatment plan per technique. Often, some dose metrics favor one plan and others favor the other, so the final plan decision involves subjective preferences. Pareto front comparisons provide a more objective framework for comparing different treatment techniques. A Pareto front is the set of all treatment plans where improvement in one criterion is possible only by worsening another criterion...
December 6, 2023: Medical Physics
https://read.qxmd.com/read/38038424/management-of-tumor-volume-changes-during-preoperative-radiotherapy-for-extremity-soft-tissue-sarcoma-a-new-strategy-of-adaptive-radiotherapy
#18
JOURNAL ARTICLE
Marion Geneau De Lamarliere, Amélie Lusque, Justine Attal Khalifa, Vincent Esteyrie, Christine Chevreau, Thibaud Valentin, Dimitri Gangloff, Thomas Meresse, Louis Courtot, Philippe Rochaix, Bérénice Boulet, Eliane Graulieres, Anne Ducassou
BACKGROUND: Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan. PATIENTS AND METHODS: We included 17 patients with a lower extremity ESTS treated between 2019 and 2021 with preoperative RT, using helicoidal intensity-modulated RT (IMRT) tomotherapy, before surgical resection. We collected clinical, tumor parameters and treatment data...
December 1, 2023: Radiology and Oncology
https://read.qxmd.com/read/38013656/dosimetric-comparison-of-helical-tomotherapy-and-volumetric-modulated-arc-therapy-in-hippocampal-avoidance-whole-brain-radiotherapy
#19
JOURNAL ARTICLE
Huai-Wen Zhang, Bo Hu, Hao-Wen Pang
OBJECTIVE: This study aimed to discuss the dosimetric advantages of helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) technology in hippocampal avoidance whole-brain radiotherapy and provide references for clinical selection of ideal radiotherapy technology. METHODS: A total of 20 patients with hippocampal avoidance whole-brain radiotherapy were chosen randomly. Computed tomography (CT) and MRI scanning images were input into the treatment planning system (TPS)...
November 27, 2023: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/37993554/safety-and-efficacy-of-helical-tomotherapy-following-lung-sparing-surgery-in-locally-advanced-malignant-pleural-mesothelioma
#20
JOURNAL ARTICLE
Julian P Layer, Pascal Fischer, Cas S Dejonckheere, Gustavo R Sarria, Rebekka Mispelbaum, Sandra Tessa Hattenhauer, Shari Wiegreffe, Andrea R Glasmacher, Katharina Layer, Youness Nour, Lara Caglayan, Franziska Grau, Thomas Müdder, Mümtaz Köksal, Davide Scafa, Frank A Giordano, Alberto Lopez-Pastorini, Erich Stoelben, Leonard Christopher Schmeel, Christina Leitzen
PURPOSE: To assess the value of radiation therapy (RT) with helical tomotherapy (HT) in the management of locally advanced malignant pleural mesothelioma (MPM) receiving no or lung-sparing surgery. METHODS: Consecutive MPM cases not undergoing extrapleural pneumonectomy and receiving intensity-modulated (IM) HT were retrospectively evaluated for local control, distant control, progression-free survival (PFS), and overall survival (OS). Impact of age, systemic treatment, RT dose, and recurrence patterns was analyzed by univariate and multivariate analysis...
November 22, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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