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https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#1
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29207865/prognostic-value-of-nodal-suvmax-of-18f-fdg-pet-ct-in-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#2
So Jung Lee, Chul-Seoung Kay, Yeon-Sil Kim, Seok Hyun Son, Myungsoo Kim, Sea-Won Lee, Hye Jin Kang
Purpose: To investigate the predictive role of maximum standardized uptake value (SUVmax) of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in nasopharyngeal cancer patients treated with intensitymodulated radiotherapy (IMRT). Materials and Methods: Between October 2006 and April 2016, 53 patients were treated with IMRT in two institutions and their PET/CT at the time of diagnosis was reviewed. The SUVmax of their nasopharyngeal lesions and metastatic lymph nodes (LN) was recorded...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#3
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29197746/proton-therapy-for-locally-advanced-breast-cancer-a-systematic-review-of-the-literature
#4
REVIEW
Emmanuel Kammerer, Jennifer Le Guevelou, Abdulhamid Chaikh, Serge Danhier, Julien Geffrelot, Christelle Levy, Eric Saloux, Jean-Louis Habrand, Juliette Thariat
BACKGROUND: Radiation therapy plays a major role in the management of adjuvant breast cancer with nodal involvement, with an iatrogenic increase of cardio-vascular risk. Photon therapy, even with intensity modulation, has the downsides of high mean heart dose and heterogeneous target coverage, particularly in the case of internal mammary irradiation. This systematic review of the literature aims to evaluate proton therapy in locally advanced breast cancer. MATERIAL AND METHODS: PubMed was searched for original full-text articles with the following search terms: «Proton Therapy» and «Breast Cancer»...
November 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29179501/the-heterogeneous-ctv-ptv-margins-should-be-given-for-different-parts-of-tumors-during-tomotherapy
#5
Ying Tong, Guanzhong Gong, Jinhu Chen, Jie Lu, Tonghai Liu, Pinjing Cheng, Yong Yin
Objective: The purpose of this study was to evaluate CTV-PTV margins of tumors for tomotherapy. Methods: Setup errors were analyzed for 151 patients receiving helical tomotherapy treatment. 53 patients had head and neck tumors, 45 had thoracic tumors, 20 had abdominal tumors, and 33 had pelvic tumors. The setup errors were calculated in six directions, i.e. +X (left), -X (right), +Y (head), -Y (foot), +Z (ventral), and -Z (dorsal), after Megavoltage CT (MVCT) images were registered to simulation CT images...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29173909/voxel-by-voxel-correlation-between-radiologically-radiation-induced-lung-injury-and-dose-after-image-guided-intensity-modulated-radiotherapy-for-lung-tumors
#6
Michele Avanzo, Sara Barbiero, Marco Trovo, Jean-Pierre Bissonnette, Rajesh Jena, Joseph Stancanello, Giovanni Pirrone, Fabio Matrone, Emilio Minatel, Cristina Cappelletto, Carlo Furlan, David A Jaffray, Giovanna Sartor
PURPOSE: To correlate radiation dose to the risk of severe radiologically-evident radiation-induced lung injury (RRLI) using voxel-by-voxel analysis of the follow-up computed tomography (CT) of patients treated for lung cancer with hypofractionated helical Tomotherapy. METHODS AND MATERIALS: The follow-up CT scans from 32 lung cancer patients treated with various regimens (5, 8, and 25 fractions) were registered to pre-treatment CT using deformable image registration (DIR)...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29139208/a-knowledge-based-approach-to-automated-planning-for-hepatocellular-carcinoma
#7
Yujie Zhang, Tingting Li, Han Xiao, Weixing Ji, Ming Guo, Zhaochong Zeng, Jianying Zhang
PURPOSE: To build a knowledge-based model of liver cancer for Auto-Planning, a function in Pinnacle, which is used as an automated inverse intensity modulated radiation therapy (IMRT) planning system. METHODS AND MATERIALS: Fifty Tomotherapy patients were enrolled to extract the dose-volume histograms (DVHs) information and construct the protocol for Auto-Planning model. Twenty more patients were chosen additionally to test the model. Manual planning and automatic planning were performed blindly for all twenty test patients with the same machine and treatment planning system...
November 15, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29136280/transitqa-a-new-method-for-transit-dosimetry-of-tomotherapy-patients
#8
Olivier Pisaturo, Frédéric Miéville, Pierre-Alain Tercier, Abdelkarim Said Allal
PURPOSE: TransitQA is an innovative method for Tomotherapy transit dosimetry using the on-board detector (OBD). Our previously published model for Tomotherapy treatment plan verification (AirQA) has been enhanced to take into account patient and couch transmission. AirQA estimates the OBD signal during irradiation with nothing in the beam path from the leaf control sinogram, allowing us to check whether the planned treatment is correctly delivered by the machine. TransitQA allows us to check the treatment delivery with the patient on the couch, potentially showing the effects of changes in the patient anatomy and delivery errors...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29132803/high-dose-irradiation-after-pleurectomy-decortication-or-biopsy-for-pleural-mesothelioma-treatment
#9
E Parisi, A Romeo, A Sarnelli, G Ghigi, S R Bellia, E Neri, S Micheletti, B Dipalma, D Arpa, G Furini, M A Burgio, G Genestreti, C Gurioli, S Sanna, P Bovolato, F Rea, G Storme, E Scarpi, C Arienti, A Tesei, R Polico
PURPOSE: The role played by radiation therapy after pleurectomy/decortication or surgical biopsy in malignant pleural mesothelioma is uncertain. We treated patients with accelerated hypofractionated radiotherapy using helical tomotherapy and intensity-modulated arc therapy in an attempt to keep lung toxicity to a minimum. The present study reports the feasibility and toxicity of this approach. MATERIAL AND METHODS: Between 2008 and 2012, 36 patients with malignant pleural mesothelioma underwent accelerated hypofractionated radiotherapy to the hemithorax after pleurectomy/decortication (19 patients) or biopsy (17 patients)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29125328/automated-retrieval-of-radiotherapy-data-for-clinical-trials-audit-and-research
#10
Marina Romanchikova, Karl Harrison, Neil G Burnet, Andrew Fc Hoole, Michael Pf Sutcliffe, Michael Andrew Parker, Rajesh Jena, Simon J Thomas
OBJECTIVE: To enable fast and customisable automated collection of radiotherapy data from tomotherapy storage. METHODS: Human-readable data maps (TagMaps) were created to generate DICOM-RT data from tomotherapy archives, and provided access to "hidden" information comprising delivery sinograms, positional corrections and adaptive-RT doses. RESULTS: 797 datasets totalling 25,000 scans were batch-exported in 31.5 hours. All archived information was restored, including the data not available via commercial software...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29122556/effect-of-imaging-frequency-on-ptv-margins-and-geographical-miss-during-image-guided-radiation-therapy-for-prostate-cancer
#11
Meetakshi Gupta, Poonam Gamre, Sadhana Kannan, Ganesh Rokde, Rahul Krishnatry, Vedang Murthy
BACKGROUND: The relationship between frequency of imaging during image guided radiation therapy (IGRT) and planning target volume (PTV) margin remains unclear. This issue is of practical significance given resource and time intensive nature of IGRT. The purpose of this study was to evaluate PTV margins with predefined and commonly used less-than-daily IGRT schedules using data obtained from patients treated with daily IGRT for prostate cancer. METHODS AND MATERIALS: Daily setup error and 3-dimensional daily alignment data for a total of 108 consecutive patients with prostate cancer treated with 2700 fractions of daily image guidance on tomotherapy were retrospectively analyzed...
October 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29110732/normal-lung-sparing-tomotherapy-technique-in-stage-iii-lung-cancer
#12
Chae-Seon Hong, Sang Gyu Ju, Yong Chan Ahn, Gyu Sang Yoo, Jae Myoung Noh, Dongryul Oh, Kwangzoo Chung, Hongryull Pyo, Kwanghyun Jo
PURPOSE: Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for stage III non-small cell lung cancer (NSCLC). Comparative analyses on plan quality by 3 different Intensity-modulated radiation therapy (IMRT) methods with BAO were done. MATERIALS AND METHODS: Ten consecutive stage IIIB NSCLC patients receiving linac-based static IMRT (L-IMRT) with total 66 Gy in 33 fractions to the PTV were selected...
November 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29106739/evaluation-of-tomotherapy-dose-calculations-with-intra-fractional-motion-and-motion-compensation
#13
Edward H Chao, Daniel Lucas, Eric Schnarr
PURPOSE: Anatomical motion, both cyclical and aperiodic, can impact the dose delivered during external beam radiation. In this work, we evaluate the use of a research version of the clinical TomoTherapy(®) dose calculator to calculate dose with intra-fraction rigid motion. We also evaluate the feasibility of a method of motion compensation for helical tomotherapy using the jaws and MLC. METHODS: Treatment plans were created using the TomoTherapy treatment planning system...
November 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/29101643/dosimetric-comparison-of-3-dimensional-conformal-radiotherapy-volumetric-modulated-arc-therapy-and-helical-tomotherapy-for-postoperative-gastric-cancer-patients
#14
Cem Onal, Yemliha Dölek, Berna Akkuş Yıldırım
PURPOSE: To compare dosimetric data for the planning target volume (PTV) and organs at risk (OARs) between 3-dimensional conformal radiotherapy (3DCRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy [1]. MATERIALS AND METHODS: The dosimetric data for 15 gastric cancer patients treated with 3DCRT, VMAT, or HT techniques were used. Cumulative dosimetric parameters, homogeneity index (HI), and conformal index (CI) were compared for the PTV and OARs...
November 3, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29093491/dosimetric-comparison-of-the-helical-tomotherapy-volumetric-modulated-arc-therapy-and-fixed-field-intensity-modulated-radiotherapy-for-stage-iib-iiib-non-small-cell-lung-cancer
#15
Yujin Xu, Weiye Deng, Shuangyan Yang, Pu Li, Yue Kong, Ye Tian, Zhongxing Liao, Ming Chen
The study aimed to compare the dosimetric parameters to target dose coverage and the critical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiotherapy (IMRT) for NSCLC delivering conventionally fractionated radiotherapy. Thirty patients with pathologically confirmed NSCLC were included. Three radiation treatment plans were designed for each patient. All patients received the uniform prescription dose of 60 Gy to the planning target volume...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29048329/measurement-and-modeling-of-out-of-field-doses-from-various-advanced-post-mastectomy-radiotherapy-techniques
#16
Jihyung Yoon, David Heins, Xiaodong Zhao, Mary Sanders, Rui Zhang
More and more advanced radiotherapy techniques have been adopted for post-mastectomy radiotherapies (PMRT). Patient dose reconstruction is challenging for these advanced techniques because they increase the low out-of-field dose area while the accuracy of out-of-field dose calculations by current commercial treatment planning systems (TPSs) is poor. We aim to measure and model the out-of-field radiation doses from various advanced PMRT techniques. PMRT treatment plans for an anthropomorphic phantom were generated, including volumetric modulated arc therapy (VMAT) with standard and flattening-filter-free (FFF) photon beams, mixed beam therapy, 4-field intensity modulated radiation therapy (IMRT), and Tomotherapy...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29031915/experimental-and-monte-carlo-based-determination-of-the-beam-quality-specifier-for-tomotherapyhd-treatment-units
#17
S Howitz, M Schwedas, T Wiezorek, K Zink
Reference dosimetry by means of clinical linear accelerators in high-energy photon fields requires the determination of the beam quality specifier TPR20,10, which characterizes the relative particle flux density of the photon beam. The measurement of TPR20,10 has to be performed in homogenous photon beams of size 10×10cm(2) with a focus-detector distance of 100cm. These requirements cannot be fulfilled by TomoTherapy treatment units from Accuray. The TomoTherapy unit provides a flattening-filter-free photon fan beam with a maximum field width of 40cm and field lengths of 1...
October 11, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#18
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28982908/long-term-tumor-control-and-late-toxicity-in-patients-with-prostate-cancer-receiving-hypofractionated-2-2-gy-soft-tissue-matched-image-guided-intensity-modulated-radiotherapy
#19
Daisuke Shimizu, Hideya Yamazaki, Takuya Nishimura, Norihiro Aibe, Haruumi Okabe
AIM: We report the long-term tumor control and toxicity outcomes of patients undergoing hypofractionated (2.2 Gy) image-guided intensity-modulated radiotherapy (IG-IMRT) using tomotherapy for clinically localized prostate cancer. PATIENTS AND METHODS: We examined the cases of 138 consecutive patients with stage T1-T3 prostate cancer that were treated with IG-IMRT from June 2007 to July 2009. The median follow-up time was 79 months (range=31-96 months). The planning target volume received a dose of 72...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982897/interfractional-rectal-displacement-requiring-repeated-precaution-did-not-correlate-to-biochemical-control-and-rectal-toxicity-in-patients-with-prostate-cancer-treated-with-image-guided-intensity-modulated-radiation-therapy
#20
Kazuki Iwama, Hideya Yamazaki, Daisuke Shimizu, Gen Suzuki, Satoaki Nakamura, Naomi Sasaki, Tadashi Takeneka, Haruumi Okabe, Tatsuyuki Nishikawa, Ken Yoshida
AIM: To investigate the correlation between frequency of action level of interfractional rectal displacement requiring repeated precaution in patients with prostate cancer and late toxicity from image-guided intensity-modulated radiation therapy (IG-IMRT) using helical tomotherapy. PATIENTS AND METHODS: We examined 264 patients who underwent IG-IMRT during 2007-2011. Megavoltage computed tomographic (MVCT) images were acquired before radiation therapy and was examined with soft-tissue matching by comparing treatment planning images within 9,345 fractions...
October 2017: Anticancer Research
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