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https://www.readbyqxmd.com/read/28096196/craniospinal-irradiation-using-helical-tomotherapy-for-central-nervous-system-tumors
#1
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
January 17, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28089479/estimation-of-radiation-induced-secondary-cancer-risks-for-early-stage-non-small-cell-lung-cancer-patients-after-stereotactic-body-radiation-therapy
#2
Chunhui Han, Timothy E Schultheiss, Jeffrey Y C Wong
PURPOSE: In this study, we evaluated radiation-induced secondary lung cancer risks for the lung and the breast from stereotactic body radiation therapy treatment of early-stage non-small cell lung cancer with different radiation therapy treatment modalities. METHODS AND MATERIALS: Ten patients (5 men and 5 women) with early-stage non-small cell lung cancer who received definitive stereotactic body radiation therapy treatments were retrospectively selected. For each patient, two 3-dimensional conformal radiation therapy (3D-CRT) plans using 6- and 10-MV photons, respectively; a helical tomotherapy (HT) plan; and 2 volumetric modulated arc therapy (VMAT) plans using 1 and 2 arcs, respectively, were generated...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28061474/tomotherapy-as-an-adjuvant-treatment-for-gastroesophageal-junction-and-stomach-cancer-may-reduce-bowel-and-bone-marrow-toxicity-compared-to-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#3
Xin Wang, Yuan Tian, Yuan Tang, Zhi-Hui Hu, Jia-Jia Zhang, Gui-Shan Fu, Pan Ma, Hua Ren, Tao Zhang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Jing Jin
PURPOSE: To compare dosimetric parameters of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and tomotherapy (TOMO) in the adjuvant treatment of gastroesophageal junction (GEJ)/stomach cancer. The planning goal was to maintain high target coverage while keeping the dose to the bowel and bone marrow (BM) as low as possible. MATERIALS AND METHODS: After curative surgery, 16 patients with GEJ/stomach cancer were re-planned by coplanar IMRT (five fixed beam), VMAT (double-arc), and TOMO...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28048924/mo-b-brb-02-3d-dosimetry-in-the-clinic-imrt-technique-validation-in-sweden
#4
S Ceberg
: Full three-dimensional (3D) dosimetry using volumetric chemical dosimeters probed by 3D imaging systems has long been a promising technique for the radiation therapy clinic, since it provides a unique methodology for dose measurements in the volume irradiated using complex conformal delivery techniques such as IMRT and VMAT. To date true 3D dosimetry is still not widely practiced in the community; it has been confined to centres of specialized expertise especially for quality assurance or commissioning roles where other dosimetry techniques are difficult to implement...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048921/su-f-j-127-multi-institutional-evaluation-of-setup-organ-deformation-precision-dosimetry-in-total-marrow-irradiation
#5
D Zuro, S Hui
PURPOSE: Totals Marrow Irradiation (TMI) is a highly focused radiation delivery to the human skeleton structure therefore requiring a high amount of precision and accuracy for a quality treatment. Not much is known on how the patient position varies across multiple treatment fractions and how that positioning impacts the dose delivery. Currently TMI is studied as an international collaboration with multiple centers around the world; however, many of these centers used different pretreatment techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048694/su-f-j-62-assessment-of-dose-changes-due-to-anterior-posterior-patient-separation-during-daily-mvct-scans
#6
M Leney, A Nalichowski, S Patel
PURPOSE: To determine the effects of patient separation on absolute dose and dose distribution in patients undergoing pelvic radiotherapy on TomoTherapy. METHODS: An Alderson RANDO phantom with 4cm of bolus was imaged on a CT simulator and the resulting scans were contoured as a whole pelvic case. Using TomoTherapy Planning Station, the plan was designed to give 45 Gy to 95% of the treatment volume in 25 fractions. TomoTherapy MVCT scans were performed on the RANDO phantom with 2cm and 4cm of bolus removed to simulate visible changes in a patient's anatomy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048660/tu-b-201-01-an-overview-of-tg-180
#7
G Ding
: Radiotherapy is in the era of image guided radiation therapy (IGRT) in which imaging procedures are routinely performed for patient positioning, and target localization. The additional imaging dose delivered may increase risk to the patient and therefore needs to be managed. This lecture provides an overview of the AAPM TG-180 which is charged with: providing an overview on imaging dose including megavoltage electronic portal imaging (MV EPI), kilovoltage digital radiography (kV DR), Tomotherapy MV-CT, megavoltage cone-beam CT (MV-CBCT) and kilovoltage cone-beam CT (kV-CBCT) as well as providing general guidelines for commissioning and managing imaging dose calculations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048628/su-f-t-353-effect-of-planning-parameters-on-tomotherapy-plan-quality-and-treatment-time
#8
Rajesh Thiyagarajan, K P Karrthick, Tejinder Kataria, N Arunai Nambiraj, Tamil Selvan, Josia Jose, Maragatha Veni
PURPOSE: Aim of this study is to evaluate the effect of planning parameters such as pitch & field width on tomotherapy treatment plan quality and treatment time. METHODS: We chose three treatment plans from different sites for this study. Combination of three different field widths (1 cm, 2.5 cm & 5 cm) and three different pitch values (0.215, 0.287 & 0.430) are used to generate plans. For a given patient all plans were optimized with same objectives, constrains, number of iterations and modulation factor...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048605/su-f-t-331-the-effect-of-optimization-grid-size-on-helical-tomotherapy-for-nasopharyngeal-carcinama
#9
J Gu, Y Yin, J Zhu
PURPOSE: To investigate the effect of plan optimization grid size on helical tomotherapy for nasopharyngeal carcinoma (NPC) METHODS: Ten patients of NPC were enrolled. For each patient, three plans with different dose optimization grid size (fine, normal, coarse) were created by Helical Tomotherapy Planning Station (version: 5.0, GPU Acceleration and VoLo).The time consumed by 500 optimization iterations, the monitor units and the dose volume histogram factors were compared. Paired-Wilcoxon test was used in statistical analysis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048587/tu-h-brc-07-therapeutic-benefit-in-spatially-fractionated-radiotherapy-grid-using-helical-tomotherapy
#10
G Narayanasamy, X Zhang, A Meigooni, X Liang, N Paudel, S Morrill, S Maraboyina, L Peacock, J Penagaricano
PURPOSE: The aim of this project is to study the therapeutic ratio (TR) for helical Tomotherapy (HT) based spatially fractionated radiotherapy (GRID). Estimation of TR was based on the linear-quadratic cell survival model by comparing the normal cell survival in a HT GRID to that of a uniform dose delivery in an open-field for the same tumor survival. METHODS: HT GRID plan was generated using a patient specific virtual GRID block pattern of non-divergent, cylinder shaped holes using MLCs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048579/su-f-t-389-validation-in-4d-dosimetry-using-dynamic-phantom
#11
C Lin, T Huang, C Lin, H Nien, P Tu, L Lui, C Wu
PURPOSE: Tumor motion due to respiration causes the uncertainties during the radiotherapy. This study aims to find the differences between planning dose by treatment planning and the received dose using dynamic phantom. METHODS: Respiratory motion was simulated by the DYNAMIC THORAX PHANTOM (Model 008A). 4D-CT scans and maximum intensity projection (MIP) images for GTV were acquired for analysis. The amplitude of craniocaudal tumor motion including 2mm, 5mm, 10mm and 20mm with 3cm2 tumor size were performed in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048523/we-de-bra-09-fast-megavoltage-ct-imaging-with-rapid-scan-time-and-low-imaging-dose-in-helical-tomotherapy
#12
T Magome, A Haga, Y Takahashi, K Nakagawa, K Dusenbery, S Hui
PURPOSE: Megavoltage computed tomography (MVCT) imaging has been widely used for daily patient setup with helical tomotherapy (HT). One drawback of MVCT is its very long imaging time, owing to slow couch speed. The purpose of this study was to develop an MVCT imaging method allowing faster couch speeds, and to assess its accuracy for image guidance for HT. METHODS: Three cadavers (mimicking closest physiological and physical system of patients) were scanned four times with couch speeds of 1, 2, 3, and 4 mm/s...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048393/su-f-t-529-dosimetric-investigation-of-a-rotating-gamma-ray-system-for-imagedguided-modulated-arc-radiotherapy
#13
C Ma, O Chibani, A Eldib, J Li, L Chen
PURPOSE: Because of their effectiveness and efficiency, rotational arc radiotherapy (MAT) techniques have been developed on both specialty machines such as Tomotherapy and conventional linear accelerators. This work investigates a new rotating Gamma therapy system for image guided MAT and SBRT of intra/extracranial tumors. METHODS: The CyberMAT system (Cyber Medical Corp., China) consists of a ring gantry with a gamma source (effective source size 1cm and 1.7cm respectively), a 120-leaf MLC, a kV CBCT and an EPID...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048286/su-g-bra-14-dose-in-a-rigidly-moving-phantom-with-jaw-and-mlc-compensation
#14
E Chao, D Lucas
PURPOSE: To validate dose calculation for a rigidly moving object with jaw motion and MLC shifts to compensate for the motion in a TomoTherapy™ treatment delivery. METHODS: An off-line version of the TomoTherapy dose calculator was extended to perform dose calculations for rigidly moving objects. A variety of motion traces were added to treatment delivery plans, along with corresponding jaw compensation and MLC shift compensation profiles. Jaw compensation profiles were calculated by shifting the jaws such that the center of the treatment beam moved by an amount equal to the motion in the longitudinal direction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048274/mo-b-brb-03-3d-dosimetry-in-the-clinic-validating-special-techniques
#15
T Juang
: Full three-dimensional (3D) dosimetry using volumetric chemical dosimeters probed by 3D imaging systems has long been a promising technique for the radiation therapy clinic, since it provides a unique methodology for dose measurements in the volume irradiated using complex conformal delivery techniques such as IMRT and VMAT. To date true 3D dosimetry is still not widely practiced in the community; it has been confined to centres of specialized expertise especially for quality assurance or commissioning roles where other dosimetry techniques are difficult to implement...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048256/su-f-t-667-development-and-validation-of-dose-calculation-for-an-open-source-kv-treatment-planning-system-for-small-animal-radiotherapy
#16
S Prajapati, X Mo, B Bednarz, M Lawless, C Hammer, R Flynn, D Westerly, R Jeraj, T Mackie
PURPOSE: An open-source, convolution/superposition based kV-treatment planning system(TPS) was developed for small animal radiotherapy from previously existed in-house MV-TPS. It is flexible and applicable to both step and shoot and helical tomotherapy treatment delivery. For initial commissioning process, the dose calculation from kV-TPS was compared with measurements and Monte Carlo(MC) simulations. METHODS: High resolution, low energy kernels were simulated using EGSnrc user code EDKnrc, which was used as an input in kV-TPS together with MC-simulated x-ray beam spectrum...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048008/su-f-t-289-mlc-fluence-sonogram-based-delivery-quality-assurance-for-bilateral-breast-irradiation
#17
Rajesh Thiyagarajan, K P Karrthick, Tejinder Kataria, N Arunai, Nambi Raj, Ramu Mahendran, Tamil Selvan, Palani Duraikannu
PURPOSE: Performing DQA for Bilateral (B-L) breast tomotherapy is a challenging task due to the limitation of any commercially available detector array or film. Aim of this study is to perform DQA for B-L breast tomotherapy plan using MLC fluence sinogram. METHODS: Treatment plan was generated on Tomotherapy system for B-L breast tumour. B-L breast targets were given 50.4 Gy prescribed over 28 fractions. Plan is generated with 6 MV photon beam & pitch was set to 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047993/tu-b-201-02-accounting-for-kv-imaging-dose
#18
P Alaei
: Radiotherapy is in the era of image guided radiation therapy (IGRT) in which imaging procedures are routinely performed for patient positioning, and target localization. The additional imaging dose delivered may increase risk to the patient and therefore needs to be managed. This lecture provides an overview of the AAPM TG-180 which is charged with: providing an overview on imaging dose including megavoltage electronic portal imaging (MV EPI), kilovoltage digital radiography (kV DR), Tomotherapy MV-CT, megavoltage cone-beam CT (MV-CBCT) and kilovoltage cone-beam CT (kV-CBCT) as well as providing general guidelines for commissioning and managing imaging dose calculations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047982/su-f-t-267-a-clarkson-based-independent-dose-verification-for-the-helical-tomotherapy
#19
H Nagata, H Hongo, D Kawai, R Takahashi, H Hashimoto, H Tachibana
PURPOSE: There have been few reports for independent dose verification for Tomotherapy. We evaluated the accuracy and the effectiveness of an independent dose verification system for the Tomotherapy. METHODS: Simple MU Analysis (SMU, Triangle Product, Ishikawa, Japan) was used as the independent verification system and the system implemented a Clarkson-based dose calculation algorithm using CT image dataset. For dose calculation in the SMU, the Tomotherapy machine-specific dosimetric parameters (TMR, Scp, OAR and MLC transmission factor) were registered as the machine beam data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047953/su-f-t-383-robustness-for-patient-setup-error-in-total-body-irradiation-using-volumetric-modulated-arc-therapy-vmat
#20
Y Takahashi, H Tachibana, N Nakamura
PURPOSE: Total body irradiation (TBI) and total marrow irradiation (TMI) using Tomotherapy have been reported. A gantry-based linear accelerator uses one isocenter during one rotational irradiation. Thus, 3-5 isocenter points should be used for a whole plan of TBI-VMAT during smoothing out the junctional dose distribution. IGRT provides accurate and precise patient setup for the multiple junctions, however it is evident that some setup errors should occur and affect accuracy of dose distribution in the area...
June 2016: Medical Physics
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