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https://www.readbyqxmd.com/read/28815060/defective-expression-of-atg4d-abrogates-autophagy-and-promotes-growth-in-human-uterine-fibroids
#1
Abdeljabar El Andaloussi, Samar Habib, Gizem Soylemes, Archana Laknaur, Heba Elhusseini, Ayman Al-Hendy, Nahed Ismail
Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28815020/advances-on-minimally-invasive-approach-for-benign-total-hysterectomy-a-systematic-review
#2
REVIEW
Marina de Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão
Hysterectomy is one of the most commonly performed gynecologic surgeries, mainly for uterine myomas, abnormal uterine bleeding, and prolapses. It can be performed through several routes, each of which has its advantages and disadvantages. We conducted this systematic review to evaluate recent advances in surgical outcomes of benign total hysterectomies by any route: vaginal (VH), laparoscopic (LH), laparoscopically assisted vaginal (LAVH), single-port (SP), and robotic-assisted laparoscopy (RH). The search was applied to the PubMed electronic database by using keywords "hysterectomy" and "uterine benign disease", "adenomyosis", and "myoma"...
2017: F1000Research
https://www.readbyqxmd.com/read/28813701/uterine-cervical-length-measurement-to-reduce-length-of-stay-in-patients-admitted-for-threatened-preterm-labor-a-randomized-trial
#3
Montse Palacio, Javier Caradeux, Miriam Sánchez, Teresa Cobo, Francesc Figueras, Oriol Coll, Eduard Gratacós, Vicenç Cararach
OBJECTIVE: To study whether knowledge of cervical length (CL) is useful in reducing the length of hospital stay in women admitted because of threatened preterm labor. METHODS: We performed a single-center, parallel, randomized trial at the Hospital Clínic of Barcelona. Inclusion criteria were single pregnancy, gestational age (GA) between 24+0 and 35+6 weeks, Bishop score <6, no parturition within 24-48 h after admission, and no clinical signs of chorioamnionitis, vaginal bleeding, or nonreassuring fetal status...
August 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28811816/unicornuate-uterus-with-a-rudimentary-horn-diagnosed-at-scheduled-third-cesarean-section
#4
Serkan Bodur, Ulas Fidan, Mehmet Ferdi Kinci, Kazim Emre Karasahin
A unicornuate uterus with a rudimentary horn is an anomaly caused by defective fusion of the Müllerian duct, estimated to occur in one in 76,000 pregnancies. Life threateningly heavy bleeding is a highly expected clinical consequence of such pregnancies. According to the known literature, only two living twins and few living singleton pregnancies have been reported up to now. Here we report on an incidentally diagnosed unicornuate uterus with a communicating rudimentary horn, found during a cesarean section of a gravida 3, parity 2 (G3 P2) patient...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810692/resveratrol-protects-from-lipopolysaccharide-induced-inflammation-in-the-uterus-and-prevents-experimental-preterm-birth
#5
María Victoria Bariani, Fernando Correa, Emma Leishman, Ana Paula Domínguez Rubio, Andreína Arias, Aníbal Stern, Heather B Bradshaw, Ana María Franchi
STUDY QUESTION: Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? SUMMARY ANSWER: Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. WHAT IS KNOWN ALREADY: Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28805608/the-utility-and-effectiveness-of-an-internal-iliac-artery-balloon-occlusion-catheter-in-surgery-for-large-cervical-uterine-fibroids
#6
Hiroshi Kaneda, Yasuhisa Terao, Yuko Matsuda, Kazunari Fujino, Takafumi Ujihira, Soshi Kusunoki, Miki Kimura, Akihiko Shiraishi, Ryohei Kuwatsuru, Satoru Takeda
OBJECTIVE: Surgery for uterine cervical fibroids is difficult because of restricted surgical access and risks such as intraoperative bleeding or injury to other organs. The internal iliac artery balloon occlusion catheter (IIABOC) provides effective hemostasis for placenta previa and atonic hemorrhage, and is increasingly used in surgery for uterine fibroids for controlling intraoperative hemorrhage. We investigated the efficacy and safety of the IIABOC for controlling intraoperative bleeding in total abdominal hysterectomies (TAH) and abdominal myomectomies (AM) for large cervical fibroids...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28803811/office-operative-hysteroscopy-an-update
#7
REVIEW
Christina Alicia Salazar, Keith Isaacson
Hysteroscopy is considered the gold standard for evaluation of intracavitary pathology associated with both pre- and postmenopausal patients with abnormal uterine bleeding as well as part of the evaluation of infertility patients with suspected cavity abnormalities. Office-based operative hysteroscopy allows patients to resume activities immediately and successfully integrates clinical practice into a "see and treat" modality, avoiding the added risks of undergoing anesthesia and the inconvenience of going to the operating room...
August 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28802955/hysterscopic-resection-of-premalignant-and-malignant-endometrial-polyps-is-it-a-safe-alternative-to-hysterectomy
#8
Osnat Elyashiv, Ron Sagiv, Ram Kerner, Ran Keidar, Joseph Menczer, Tally Levy
STUDY OBJECTIVE: The standard treatment of endometrial cancer (EC) and complex atypical hyperplasia (CAH) is hysterectomy with or without adnexectomy. In the last decade, several centers have attempted to perform hysteroscopic resection of malignant and pre-malignant polyps as an alternative to hysterectomy. In the present study, we evaluated the safety of this procedure in regard to residual uterine pathology. DESIGN: Retrospective chart review DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: University hospital PATIENTS: 1766 women who underwent hysteroscopic polypectomy during the years 1998-2016 MEASUREMENTS: Patients with CAH and endometrioid type EC in the removed polyps who underwent hysterectomy were included in the study...
August 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28797151/-comparison-of-the-safety-of-two-treatment-methods-of-cesarean-scar-pregnancy-of-type%C3%A2-and-%C3%A2-in-menopause-within-7-weeks
#9
X Y Wei, X L Yu
Objective: To comparison of the safety of two treatment methods of cesarean scar pregnancy (CSP) of typeⅡ and Ⅲ in menopause within 7 weeks. Methods: Totally 70 cases of CSP of typeⅡ and Ⅲ within 7 weeks of the last menstrual period, hospitalized within Peking University First Hospital from January 2009 to May 2016, had been retrospectively studied in two groups of different treatments. The methotrexate (MTX) treatment group included 37 cases receiving ultrasound-guided complete curettage of uterine cavity combined with MTX therapy, while the uterine artery embolization (UAE) group had 33 cases treated with UAE combined with MTX therapy and subsequent ultrasound-guided complete curettage of uterine cavity...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28796898/comparison-of-the-levonorgestrel-releasing-intrauterine-system-hysterectomy-and-endometrial-ablation-for-heavy-menstrual-bleeding-in-a-decision-analysis-model
#10
REVIEW
Michelle Louie, Jennifer Spencer, Stephanie Wheeler, Victoria Ellis, Tarek Toubia, Lauren D Schiff, Matthew T Siedhoff, Janelle K Moulder
BACKGROUND: A better understanding of the relative risks and benefits of common treatment options for abnormal uterine bleeding (AUB) can help providers and patients to make balanced, evidence-based decisions. OBJECTIVES: To provide comparative estimates of clinical outcomes after placement of levonorgestrel-releasing intrauterine system (LNG-IUS), ablation, or hysterectomy for AUB. SEARCH STRATEGY: A PubMED search was done using combinations of search terms related to abnormal uterine bleeding, LNG-IUS, hysterectomy, endometrial ablation, cost-benefit analysis, cost-effectiveness, and quality-adjusted life years...
August 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28796688/optimal-order-of-successive-office-hysteroscopy-and-endometrial-biopsy-for-the-evaluation-of-abnormal-uterine-bleeding-a-randomized-controlled-trial
#11
Papri Sarkar, Emad Mikhail, Robyn Schickler, Shayne Plosker, Anthony N Imudia
OBJECTIVE: To estimate the optimal order of office hysteroscopy and endometrial biopsy when performed successively for evaluation of abnormal uterine bleeding. METHODS: Patients undergoing successive office hysteroscopy and endometrial biopsy were included in a single-blind, prospective, randomized trial. The primary outcome was to evaluate the effect of order of procedures on patients' pain score. Prespecified secondary outcomes include procedure duration, hysteroscopic visualization of the uterine cavity, endometrial sample adequacy, and number of attempts at biopsy...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796686/a-transperineal-approach-to-hysterectomy-of-a-retained-didelphic-uterine-horn
#12
Mary M Mullen, Lindsay M Kuroki, Steven R Hunt, Kristy L Ratkowski, David G Mutch
BACKGROUND: Gynecologic surgeries are performed through abdominal, vaginal, laparoscopic, or robot-assisted laparoscopic routes. However, if the pelvis is not accessible by one of these routes, there are no published reports to guide pelvic surgeons. CASE: A 34-year-old conjoined twin status postseparation with uterine didelphys and absence of her left colon and sacrum underwent hemihysterectomy, at which time her müllerian anomaly was unknown. She re-presented with vaginal bleeding and pain eventually attributed to a retained uterine horn...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28795408/novasure-radiofrequency-endometrial-ablation-for-the-management-of-acute-abnormal-uterine-bleeding
#13
Shamma Al-Inizi
Radiofrequency endometrial ablation resulted in abrupt cessation of acute abnormal uterine bleeding in one case, avoiding emergency hysterectomy. Acute abnormal uterine bleeding (AUB) unrelated to pregnancy is defined as an episode of bleeding that is sufficient in volume in the opinion of the treating clinician to require urgent or emergency intervention.(1) Acute AUB is a distressing condition that poses a challenge for clinicians and consumes healthcare resources. This article is protected by copyright. All rights reserved...
August 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28794456/activated-nk-cells-cause-placental-dysfunction-and-miscarriages-in-fetal-alloimmune-thrombocytopenia
#14
Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G Sled, Stephen J Lye, Jelena Brkić, Chun Peng, Petter Höglund, B Anne Croy, S Lee Adamson, Xiao-Yan Wen, Duncan J Stewart, John Freedman, Heyu Ni
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal-fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28790785/a-randomized-control-trial-to-assess-efficacy-of-mifepristone-in-medical-management-of-uterine-fibroid
#15
D Arora, Jaya Chawla, S P S Kochar, J C Sharma
BACKGROUND: Fibroids are the most common benign tumours of uterus. Heavy menstrual bleeding is the commonest concern for which medical attention is sought. Hysterectomies for leiomyoma constitute a third of all hysterectomies. Thus, healthcare cost to society due to uterine leiomyomas is of considerable importance. METHODS: A prospective study was conducted at tertiary care hospital of armed forces. 120 women in pre-menopausal age group with complaints of menorrhagia, Pictorial Bleeding Assessment Chart (PBAC) scoring ≥100 and at least one fibroid ≥2...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28782473/importance-of-hemolysis-and-its-clinical-detection-in-neonates-with-hyperbilirubinemia
#16
Ronald J Wong, Vinod K Bhutani, David K Stevenson
Neonatal hyperbilirubinemia is generally a benign transitional phenomenon, and may even be a protective antioxidant mechanism for human neonates who may be vulnerable to the oxidative stress (compared to life in utero) encountered during birth an extra-uterine oxidative environment (1, 2). The pathophysiologic impact of neonatal unconjugated hyperbilirubinemia has been well reviewed in this supplement (see Jon fill-in). The severity of hyperbilirubinemia varies due to the magnitude of an imbalance between two major contributing processes: (i) an increase bilirubin production rate due to an increase in heme turnover (two to three times that of an adult) due to the degradation of fetal red blood cells (RBCs), which have a shortened lifespan, after birth (3, 4); and/or (ii) a diminished ability of the immature newborn liver to conjugate bilirubin and therefore excrete bilirubin in bile...
August 7, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28782399/use-of-bakri-balloon-tamponade-bbt-for-conservative-management-of-postpartum-haemorrhage-a-tertiary-referral-centre-case-series
#17
Manisha Mathur, Qiu Ju Ng, Shephali Tagore
The aim of this study was to investigate the efficacy of the Bakri balloon in the management of PPH. This was a retrospective review of 49 patients, who had Bakri balloon inserted for PPH in KK Hospital between April 2013 and December 2015. The main outcome measure was achievement of haemostasis by Bakri balloon tamponade (BBT). Our success rate was 81.6%. Out of the nine failures (18.0%), five (55.6%) had subtotal hysterectomies and four (44.4%) had total hysterectomies. The causes of PPH in these nine women were unsuspected or foci of placenta accreta (55...
August 6, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28780893/abnormal-uterine-bleeding-in-perimenopause
#18
S R Goldstein, M A Lumsden
Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Once a proper diagnosis has been established, appropriate therapy may be embarked upon...
August 7, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28767507/bleeding-out-the-qalys-evaluating-the-burden-of-primary-dysmenorrhea-by-time-trade-off-and-willingness-to-pay-methods
#19
Fanni Rencz, Márta Péntek, Peep Fm Stalmeier, Valentin Brodszky, Gábor Ruzsa, Edina Gradvohl, Petra Baji, László Gulácsi
Primary dysmenorrhea (PD), or painful menstruation in the absence of identified uterine pathology, affects five to nine in every 10 reproductive-aged women. Despite its high prevalence, just a few studies with very small patient numbers have focused on health-related quality of life (HRQoL) impairment in PD. We aimed to assess HRQoL values for a severe and a mild hypothetical PD health state by 10-year time trade-off (TTO) and willingness-to-pay (WTP) methods. In 2015, a nationwide convenience sample of women, aged between 18 and 40 years, was recruited using an Internet-based cross-sectional survey in Hungary...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28763739/risk-of-malignancy-on-suspicion-of-polyps-in-menopausal-women
#20
Sandra Bel, Camille Billard, Julien Godet, Victor Viviani, Cherif Akladios, Aline Host, Emilie Faller, Thomas Boisrame, Michel Hummel, Jean-Jacques Baldauf, Lise Lecointre, Olivier Garbin
Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. In order to do so, risk factors for malignancy need to be identified. OBJECTIVE: Estimate the prevalence of lesions in menopausal patients with a pre-operative diagnosis of endometrial polyp...
July 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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