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Uterine bleeding

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https://www.readbyqxmd.com/read/29792359/adverse-effect-analysis-of-high-intensity-focused-ultrasound-in-the-treatment-of-benign-uterine-diseases
#1
Yunchang Liu, Wendy Wenyi Zhang, Min He, Chunmei Gong, Bin Xie, Xiangxia Wen, Dandan Li, Lian Zhang
OBJECTIVE: To retrospectively analyze the adverse effects of high-intensity focused ultrasound (HIFU) in management of benign uterine diseases. MATERIALS AND METHODS: From 2011 to 2017, 27,053 patients with benign uterine diseases were treated with HIFU in 19 centers in China. Among them, 17,402 patients had uterine fibroids, 8434 had adenomyosis, 876 had caesarean scar pregnancies, and 341 had placenta accreta. RESULTS: The median age, height, weight, BMI of the patients was 42 years, 158 mm, 56 kg, 22...
May 24, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29789793/modern-myoma-treatment-in-the-last-20-years-a-review-of-the-literature
#2
REVIEW
Ahmed El-Balat, Rudy Leon DeWilde, Iryna Schmeil, Morva Tahmasbi-Rad, Sandra Bogdanyova, Ali Fathi, Sven Becker
Myomas, also known as fibroids, are a specific characteristic of the human species. No other primates develop fibroids. At a cellular level, myomas are benign hyperplastic lesions of uterine smooth muscle cells. There are interesting theoretical concepts that link the development of myomas in humans with the highly specific process of childbirth from an upright position and the resulting need for greatly increased "expulsive" forces during labor. Myomas might be the price our species pays for our bipedal and highly intelligent existence...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29788081/proteomic-characterization-of-the-extracellular-matrix-of-human-uterine-fibroids
#3
M Fairuz B Jamaluddin, Pravin Nahar, Pradeep S Tanwar
Uterine leiomyomas (fibroids) are the most common benign tumors that are associated with increased production of extracellular matrix (ECM). The excessive ECM deposition plays a major role in the enlargement and stiffness of these tumors and contributes to clinical symptoms, such as abnormal bleeding and abdominal pain. However, no study so far has explored the global composition of the ECM of fibroids and normal myometrium. In this study, we performed systematic ECM enrichment procedure and comparative proteomic analyses to profile the ECM composition of genetically annotated different size fibroids (small, medium and large) and adjacent normal myometrium (ANM)...
May 16, 2018: Endocrinology
https://www.readbyqxmd.com/read/29787604/laparoscopic-uterine-surgery-as-a-risk-factor-for-uterine-rupture-during-pregnancy
#4
An-Shine Chao, Yao-Lung Chang, Lan-Yan Yang, Angel Chao, Wei-Yang Chang, Sheng-Yuan Su, Chin-Jung Wang
The incidence of uterine rupture through a previous cesarean scar (CS) is declining as a result of a lower parity and fewer options for vaginal birth after cesarean. However, uterine ruptures attributable to other causes that traumatize the myometrium are on the rise. To determine whether changes in the causes of uterine rupture had occurred in recent years, we retrospective retrieved the clinical records of all singletons with uterine rupture observed in the delivery room of a Taiwanese tertiary obstetric center over a 15-year period...
2018: PloS One
https://www.readbyqxmd.com/read/29783003/non-malignant-sequelae-following-unconfined-power-morcellation-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#5
Hao M Zhang, Lee A Christianson, Claire L Templeman, Scott E Lentz
STUDY OBJECTIVE: To identify the incidence of repeat surgery and subsequent findings following the performance of unconfined uterine power morcellation. DESIGN: A retrospective descriptive study (Canadian Task Force II-2) SETTING: Southern California Kaiser Permanente Medical Centers PATIENTS: Women (n=5154) who underwent laparoscopic supra-cervical hysterectomy (LSH) with unconfined power morcellation. MEASUREMENTS AND MAIN RESULTS: Of the 5154 cases, 279 (5...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29781080/acquired-uterine-arteriovenous-malformation-a-diagnostic-dilemma
#6
Agata Szpera-Goździewicz, Karolina Gruca-Stryjak, Grzegorz H Bręborowicz, Mariola Ropacka-Lesiak
Uterine arteriovenous malformations are uncommon but potentially life-threatening condition. They can be congenital or acquired and should be suspected in cases of severe or persistent uterine bleeding. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, caesarean delivery and curettage. This paper presents the case of unexplained vaginal bleeding with subsequent suspicion and diagnosis of uterine arteriovenous malformation...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#7
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#8
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777346/cytological-assessment-of-endometrial-washings-obtained-with-karman-cannula-using-a-liquid-based-preparation-method-for-the-detection-of-endometrial-pathologies
#9
Cetin Kilicci, Ebru Çogendez, Pınar Kumru, Evrim Bostanci Ergen, Nermin Koc, Cigdem Abide Yayla
OBJECTIVE: The aim of this study was to evaluate the diagnostic efficacy and utility of liquid-based cytology in ThinPrep (Cytyc Corporation, Boxborough, MA) for endometrial lesions in patients presenting with abnormal uterine bleeding. MATERIALS AND METHODS: Two hundred and thirteen women scheduled for dilatation and curettage because of abnormal uterine bleeding were enrolled in the study. After providing informed consent, all the women proceeded sequentially to endometrial cytology and then dilatation and curettage...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#10
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29772407/total-laparoscopic-hysterectomy-for-endometriosis-and-an-arteriovenous-malformation
#11
Emilie Schwartz, Emilie Faller, Chérif Youssef Akladios, Michel Greget, Catherine Roy, Arnaud Wattiez
STUDY OBJECTIVE: Demonstrate a laparoscopic management of an arteriovenous malformation in a patient with deep pelvic endometriosis DESIGN: A step-by-step explanation of the surgery using video (instructive video). SETTING: Hautepierre Universitary Hospital of Strasbourg in France INTERVENTION: We describe the case of a 37 years old patient presenting deep pelvic endometriosis and an uterine arteriovenous malformation. It was during a tubal ligation in 2015, that the deep pelvic endometriosis was diagnosed...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29772406/fertility-pregnancy-and-clinical-outcomes-after-uterine-arteriovenous-malformation-management
#12
Sophie Delplanque, Maela Le Lous, Maïa Proisy, Yolaine Joueidi, Estelle Bauville, Celine Rozel, Eugénie Beraud, Bertrand Bruneau, Jean Levêque, Vincent Lavoué, Krystel Nyangoh Timoh
STUDY OBJECTIVE: To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management. DESIGN: Single-center retrospective study from January 2000 to July 2017. (Canadian task force III). SETTING: One referral center. PATIENTS: Twenty-two patients with a UAVM diagnosed by Magnetic Resonance Angiography (MRA) or Computed Tomography (CT) angiography and managed by Expectant Management (EM) or Uterine Arterial Embolization (UAE) during the study period were included...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29765929/gonadotropin-releasing-hormone-agonist-plus-aromatase-inhibitor-in-the-treatment-of-uterine-leiomyoma-in-near-menopause-patient-a-case-series-study
#13
Sanam Moradan
Objectives: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids. Methods: A cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29757875/surgery-and-platinum-etoposide-based-chemotherapy-for-the-treatment-of-epithelioid-trophoblastic-tumor
#14
Janelle Sobecki-Rausch, Abigail Winder, Kruti P Maniar, Anna V Hoekstra, Emily Berry, Karen Novak, John R Lurain
OBJECTIVE: Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia that develops from chorionic-type intermediate trophoblast, simulates carcinoma, presents years after a pregnancy event, is associated with low or normal human chorionic gonadotropin levels, and is relatively resistant to chemotherapy. Our aim was to identify the role of surgery in combination with platinum/etoposide-based chemotherapy in the management of both localized and metastatic ETT...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29753568/severe-delayed-postpartum-hemorrhage-after-cesarean-section
#15
Nirav Patel, Michael Radeos
BACKGROUND: Severe secondary or delayed postpartum hemorrhage (PPH) is rare and affects 0.23-3% of all pregnancies. It happens between 24 hours to 12 weeks postdelivery. These PPHs occur more often during normal vaginal delivery; only a small subset of these PPHs occur after cesarean section. The top differential diagnoses of both primary and secondary PPH are different, and as a result, the management may be different. Although uterine atony causes 80% of primary PPHs, extensive literature review exposed the rarity of it in the setting of secondary PPH...
May 9, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29752117/antifertility-effectiveness-of-a-novel-copper-containing-intrauterine-device-material-and-its-influence-on-the-endometrial-environment-in-rats
#16
Shifu Hu, Yingying Wang, Dandan Ke, Fang Zhou, Guiping Cheng, Wei Xia, Changhong Zhu
This study was designed to investigate the antifertility effectiveness of a novel copper-containing intrauterine device material containing a composite of micro-copper (Cu), low-density polyethylene (LDPE), and methyl vinyl silicone rubber (MVQ) and its effects on the endometrial environment in rats. The contraceptive effectiveness was examined 12 days after pregnancy. The pathological changes; factors associated with bleeding, pain, and inflammation in the endometrium; and the surface condition of the implants were investigated after insertion for 90 days...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29750705/thickened-endometrium-in-postmenopausal-women-with-an-initial-biopsy-of-limited-benign-surface-endometrium-clinical-outcome-and-subsequent-pathologic-diagnosis
#17
Josephine K T Dermawan, Christine Hur, Maria G Uberti, Rebecca Flyckt, Tommaso Falcone, Jennifer Brainard, Fadi W Abdul-Karim
Endometrial biopsy or curetting is indicated for postmenopausal women with abnormal uterine bleeding and/or thickened endometrium. Often, endometrial biopsy or curetting yields limited benign surface endometrium, which may indicate insufficient sampling. This study addresses the clinical outcome and subsequent pathologic diagnoses in postmenopausal women who received this initial diagnosis. Among a total of 370 endometrial biopsy or curetting between 2012 and 2015, 192 (52%) were diagnosed as limited benign surface endometrial epithelium...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29750127/a-potentially-useful-addition-to-predict-spontaneous-resolution-of-uterine-artery-pseudoaneurysm-absence-of-diastolic-flow
#18
Yosuke Baba, Hironori Takahashi, Hiroyuki Morisawa, Daisuke Matsubara, Kohei Tamura, Rie Usui, Shigeki Matsubara
Pregnancy-associated uterine artery pseudoaneurysm (UAP) usually requires transarterial embolization (TAE) irrespective of the presence/absence of current bleeding. Some UAP cases spontaneously resolve without TAE; however, such UAP is not well characterized. Here, we suggest that Pulse Wave Doppler may become an addition to predict its spontaneous resolution. A woman underwent 1st-trimester vaginal termination. Vaginal bleeding repeated and, 36 days later, an intrauterine low-echoic mass (24 mm) with swirling blood flow and arterial waveforms (Pulse Wave Doppler) and an enhanced intrauterine sac-like structure without current extravasation were observed, leading to the diagnosis of UAP...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29747272/-analysis-of-proliferative-lesions-of-haematopoietic-and-lymphoid-tissue-in-the-female-productive-tract
#19
D B Chen, H Zhang, Y H Zhang, Y Wang, Q J Song, S M Yang, H Cui, Y Zhao, X Z Fang, D H Shen
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of tumors of haematopoietic and lymphoid tissue in the female productive tract. Methods: Eleven cases of myeloid sarcoma and leukemia, 9 of non Hodgkin lymphoma (NHL) , 13 of cervical lymphoma-like lesions were selected from Peking University People's Hospital from January 2006 to August 2017. According to WHO classification of tumors of haematopoietic and lymphoid tissues (2008) and updated classification(2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29747267/-application-of-uterine-lower-part-breakwater-like-suture-operation-in-placenta-previa
#20
Y Zhao, J W Zhu, D Wu, Q H Wang, S S Lu, X X Liu, L Zou
Objective: To explore the efficacy and safety of uterine lower posterior wall breakwater-like suture technique in controlling the intraoperative bleeding of placenta previa. Methods: From June 2016 to June 2017, 47 patients were diagnosed placenta previa in Union Hospital, Tongji Medical College of Huazhong University of Science and Technology. Posterior wall breakwater-like suture technique was used preferentially, as for cases with poor myometrium layer, lower anterior wall stitch suture was used at the same time...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
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