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Michelle M O'Shaughnessy, Susan L Hogan, Caroline J Poulton, Ronald J Falk, Harsharan K Singh, Volker Nickeleit, J Charles Jennette
BACKGROUND AND OBJECTIVES: Large-scale, contemporary studies exploring glomerular disease epidemiology in the United States are lacking. We aimed to determine 30-year temporal and demographic trends in renal biopsy glomerular disease diagnosis frequencies in the southeastern United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional, observational study, we identified all patients with a native kidney biopsy specimen showing one of 18 widely recognized glomerular disease diagnoses referred to the University of North Carolina Chapel Hill Division of Nephropathology between 1986 and 2015...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
Fernanda Payan Schober, Meghan A Jobson, Caroline J Poulton, Harsharan K Singh, Volker Nickeleit, Ronald J Falk, J Charles Jennette, Patrick H Nachman, William F Pendergraft Iii
BACKGROUND: Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependence of patient characteristics and outcomes on race has not been explored. In this study, we describe a cohort of patients with fibrillary glomerulonephritis and compare their clinical characteristics and outcomes with those of patients previously described...
2017: American Journal of Nephrology
Wael M Hamza, Hanan H Ali, Samia M Gabal, Sawsan A Fadda
The chronic dysfunction stands as the most common cause of renal allograft loss. During the nineties of the past century, this condition was referred to as chronic allograft nephropathy (CAN). Since 2005, CAN has been assigned by the eighth Banff schema to four main categories via histopathological and immunohistochemical findings including chronic antibodymediated rejection (CAMR), chronic T-cell-mediated rejection (CTMR), chronic cyclosporine toxicity (CNITOX), and "interstitial fibrosis (IF)/tubular atrophy; not otherwise specified (NOS)" to eliminate the term CAN...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
Rachel Cianciolo, Jessica Hokamp, Mary Nabity
Many recent advances in the evaluation of dogs with kidney disease have improved our diagnostic algorithms and have impacted our therapeutic strategies. Non-invasive techniques, such as urinary and serologic biomarker evaluation, can help a clinician diagnose and treat a patient that cannot undergo a renal biopsy for clinical or financial reasons. Some biomarkers might help localize the affected structure (glomerulus vs. tubule) and indicate the type or severity of injury present. Although more research is needed, studies indicate that some biomarkers (e...
September 2016: Veterinary Journal
Sabiha Anis
No abstract text is available yet for this article.
April 2016: Journal of Nephropathology
Vanesa Bijol, Youssef M K Farag, Sudhir Shah, John Feehally, Ajay K Singh
No abstract text is available yet for this article.
May 2016: Kidney International
Malgorzata Wągrowska-Danilewicz, Marian Danilewicz
This is the first report from Poland documenting biopsy-proven renal diseases in type 2 diabetes mellitus. We analyzed the data of 76 patients with type 2 diabetes who underwent renal biopsy and were diagnosed in the Department of Nephropathology, Medical University of Lodz. The patients were divided into the following three groups according to the histological diagnosis: group I - isolated non-diabetic renal disease (NDRD); group II - NDRD superimposed on underlying diabetic nephropathy (NDRD + DN); and group III - isolated diabetic nephropathy (DN)...
December 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Jessica Hemminger, Gyongyi Nadasdy, Anjali Satoskar, Sergey V Brodsky, Tibor Nadasdy
Immunofluorescence staining plays a vital role in nephropathology, but the panel of antibodies used has not changed for decades. Further classification of immunoglobulin (Ig)G-containing immune-type deposits with IgG subclass staining (IgG1, IgG2, IgG3, and IgG4) has been shown to be of diagnostic utility in glomerular diseases, but their value in the evaluation of renal biopsies has not been addressed systematically in large renal biopsy material. Between January 2007 and June 2014, using direct immunofluorescence, we stained every renal biopsy for the IgG subclasses if there was moderate to prominent glomerular IgG staining and/or IgG-predominant or IgG-codominant glomerular staining...
May 2016: American Journal of Surgical Pathology
Patrick J Gleeson, Itzchak Slotki, Jorge B Cannata-Andia, David W P Lappin
The Renal Section of the European Union of Medical Specialists is working towards harmonization and optimization of nephrology training across Europe and its Mediterranean borders. In addition to the need for harmonization of the heterogeneous time dedicated to training, it is necessary to ensure that the learning environment is of a sufficiently high standard to develop skilled specialists. Thus, there is a need to review the core educational infrastructure and resources that should be provided to trainees in order to be considered centres of excellence for nephrology training...
February 2016: Clinical Kidney Journal
Tak-Kuan Chow, Lai-Meng Looi, Phaik-Leng Cheah
BACKGROUND: In the past, lupus nephritis was histologically classified according to the 1995 WHO Classification. With the introduction of the 2003 ISN/RPS Classification, many nephropathology services converted to this new classification. This study was undertaken to compare both classification systems in a single centre practice. METHODS: 103 consecutive adequate renal biopsies initially reported as lupus nephritis in the Department of Pathology, Faculty of Medicine, University of Malaya were reassessed using the criteria of both the 1995 WHO Classification and the 2003 ISN/ RPS Classification...
December 2015: Malaysian Journal of Pathology
Isabelle Ayoub, Salem Almaani, Sergey Brodsky, Tibor Nadasdy, Jason Prosek, Lee Hebert, Brad Rovin
BACKGROUND: It is well-established from autopsy studies that gouty tophi can form in the kidney, particularly in the renal medulla. Recently hyperuricemia has been identified as a risk factor for progression of chronic kidney disease (CKD). Because each collecting duct serves more than 2,000 nephrons, we postulated that obstruction or disruption of collecting ducts by medullary tophi may explain, at least in part, the association between hyperuricemia and progressive CKD. This work was done to determine the prevalence of medullary tophi in CKD patients...
February 2016: Clinical Nephrology
Muhammed Mubarak
No abstract text is available yet for this article.
July 2015: Journal of Nephropathology
V V Bariliak, E R Tsygankova, N A Mileshina, I G Tishkova, R Y U Bariliak
The objective of the present study was to improve the effectiveness of early diagnostics and prophylaxis of hearing disturbances in the children presenting with various chronic diseases. As is known, there are several dozens of neurologic disorders associated with hearing disorders. By way of example, there is a group of nephropathologies responsible for the loss of hearing in the children. Specifically, hearing impairment can be one of the symptoms of diabetes mellitus. The patients presenting with mucopolysaccharidosis make up a group at risk of hearing impairment...
2015: Vestnik Otorinolaringologii
Sue Hyun Lee, Jung Bok Lee, Min Soo Bae, Daniel A Balikov, Amy Hwang, Timothy C Boire, Il Keun Kwon, Hak-Joon Sung, Jae Won Yang
Significant progress has been made in nanomedicine, primarily in the form of nanoparticles, for theranostic applications to various diseases. A variety of materials, both organic and inorganic, have been used to develop nanoparticles with promise to achieve improved efficacy in medical applications as well as reduced systemic side effects compared to current standard of care medical practices. In particular, this article highlights the recent development and application of nanoparticles for diagnosing and treating nephropathologies...
September 16, 2015: Advanced Healthcare Materials
Benjamin Adam, Michael Mengel
In the current era of precision medicine, the existing nephropathology paradigm of light microscopy, immunofluorescence, and electron microscopy will become increasingly insufficient. There will be an expectation to supplement these traditional diagnostic tools with patient-specific information related to a growing understanding of molecular pathophysiology. Next generation sequencing technologies are expected to play a key role in the future of nephropathology, but transcriptomics is poised to represent the first major foray into routine molecular testing...
August 1, 2015: American Journal of Physiology. Renal Physiology
R E Cianciolo, F C Mohr, L Aresu, C A Brown, C James, J H Jansen, W L Spangler, J J van der Lugt, P H Kass, C Brovida, L D Cowgill, R Heiene, D J Polzin, H Syme, S L Vaden, A M van Dongen, G E Lees
Evaluation of canine renal biopsy tissue has generally relied on light microscopic (LM) evaluation of hematoxylin and eosin-stained sections ranging in thickness from 3 to 5 µm. Advanced modalities, such as transmission electron microscopy (TEM) and immunofluorescence (IF), have been used sporadically or retrospectively. Diagnostic algorithms of glomerular diseases have been extrapolated from the World Health Organization classification scheme for human glomerular disease. With the recent establishment of 2 veterinary nephropathology services that evaluate 3-µm sections with a panel of histochemical stains and routinely perform TEM and IF, a standardized objective species-specific approach for the diagnosis of canine glomerular disease was needed...
January 2016: Veterinary Pathology
Xiuju Wu, Richard C Davis, Timothy S McMillen, Valerie Schaeffer, Zhiqiang Zhou, Hongxiu Qi, Parisa N Mazandarani, Roshanak Alialy, Kelly L Hudkins, Aldons J Lusis, Renée C LeBoeuf
Diabetic nephropathy (DN) is a major complication of diabetes and the leading cause of end-stage renal disease. DN is characterized by changes in kidney structure and function but the underlying genetic and molecular factors are poorly understood. We used a mouse diversity panel to explore the genetic basis of DN traits in mice carrying the Ins2 Akita mutation. Twenty-eight Akita strains were generated by breeding this panel to DBA/2.Akita mice. Male F1 diabetic and nondiabetic littermates were evaluated for DN-related traits...
November 1, 2014: Physiological Reports
Alberto Mella, Maria Messina, Antonio Lavacca, Luigi Biancone
The identification of complement activity in serum and immunohistochemical samples represents a core element of nephropathology. On the basis of this observation, different experimental models and molecular studies have shown the role of this cascade in glomerular disease etiology, but the absence of inhibiting drugs have limited its importance. Since 2006, the availability of target-therapies re-defined this ancient pathway, and its blockage, as the new challenging frontier in renal disease treatment. In the graft, the complement cascade is able to initiate and propagate the damage in ischemia-reperfusion injury, C3 glomerulopathy, acute and chronic rejection, atypical hemolytic uremic syndrome and, probably, in many other conditions...
September 24, 2014: World Journal of Transplantation
Laura Barisoni
Digital technology marked the first decade of the 21st century with the advent of whole slide imaging (WSI). Thanks to the invention of digital scanners, WSI technology enables the creation and permanent storage of high resolution images from traditional glass slides. The application of digital pathology has recently been explored within the subspecialty of renal pathology for teaching, pathology-based clinical trials, development of new classification systems, and in support to systems biology-based research in a setting of large consortia...
October 2014: Pathology
Hamid Nasri, Ali Ahmadi, Azar Baradaran, Ali Momeni, Parto Nasri, Saeed Mardani, Mahmood Rafieian-Kopaei, Muhammed Mubarak
BACKGROUND: Renal biopsies play an important role in the diagnosis, management and prognosis of patients with lupus nephritis (LN). OBJECTIVES: To determine the correlation between the pathological features of LN and the demographic, clinical and laboratory parameters. PATIENTS AND METHODS: This retrospective study was conducted from 2008 to 2014 on all consecutive cases of biopsy-proven LN at a nephropathology laboratory in Iran. The demographic, clinical and laboratory data were obtained from patients(') files and the biopsy findings from the original biopsy request forms...
July 2014: Journal of Nephropathology
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