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https://www.readbyqxmd.com/read/28433416/static-postural-control-in-youth-with-osteogenesis-imperfecta-type-i
#1
Annie Pouliot-Laforte, Martin Lemay, Frank Rauch, Louis-Nicolas Veilleux
OBJECTIVE: To assess static postural control in eyes-open and eyes-closed conditions in individuals with osteogenesis imperfecta (OI) type I as compared to typically developing (TD) individuals. The second aim was to explore the relation between postural control and lower-limbs muscle function. DESIGN: This is a cross-sectional study. SETTINGS: The study was carried out in the outpatient department of a pediatric orthopedic hospital. PARTICIPANTS: 22 individuals with OI type I (mean age [range]: 13...
April 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28433348/the-influence-of-polyethylene-bearing-thickness-on-the-tibiofemoral-kinematics-of-a-bicruciate-retaining-total-knee-arthroplasty
#2
Geert Peersman, Josh Slane, Margo Dirckx, Arne Vandevyver, Philipp Dworschak, Thomas J Heyse, Lennart Scheys
BACKGROUND: The recently reintroduced bicruciate retaining Total Knee Arthroplasty (BCR TKA) is an effort to reproduce kinematics closer to the native knee. However, there is no data on appropriate balancing with this implant. Balancing is crucial and challenging as medial and lateral polyethylene (PE) inlays are modular, which allows for placement of different thicknesses in the medial and lateral compartments. This study aimed at providing a detailed kinematic view on balancing BCR TKA...
April 19, 2017: Knee
https://www.readbyqxmd.com/read/28430427/performance-of-the-amoeba-water-model-in-the-vicinity-of-qm-solutes-a-diagnosis-using-energy-decomposition-analysis
#3
Yuezhi Mao, Yihan Shao, Jacek Dziedzic, Chris-Kriton Skylaris, Teresa Head-Gordon, Martin Head-Gordon
The importance of incorporating solvent polarization effects into the modeling of solvation processes has been well-recognized, and therefore a new generation of hybrid quantum mechanics/molecular mechanics (QM/MM) approaches that accounts for this effect is desirable. We present a fully self-consistent, mutually polarizable QM/MM scheme using the AMOEBA force field, in which the total energy of the system is variationally minimized with respect to both the QM electronic density and the MM induced dipoles. This QM/AMOEBA model is implemented through the Q-Chem/LibEFP code interface and then applied to the evaluation of solute-solvent interaction energies for various systems ranging from the water dimer to neutral and ionic solutes (NH3, NH4(+) , CN(-)) surrounded by increasing numbers of water molecules (up to 100)...
April 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28430420/a-thorium-chalcogenolate-series-generated-by-atom-insertion-into-thorium-carbon-bonds
#4
Nicholas S Settineri, Mary E Garner, John Arnold
A new thorium monoalkyl complex, Th(CH2SiMe3)(L3) (L = MeC(N(i)Pr)2) (2), undergoes insertion of chalcogen atoms resulting in a series of thorium chalcogenolate complexes, Th(ECH2SiMe3)(L3) (E = S, SS, Se, Te; 5-8). Complex 6 represents the first alkyl disulfide thorium species and illustrates the ability of 2 to undergo controllable, stoichiometric atom insertion. All complexes have been characterized by (1)H and (13)C NMR spectroscopy, FTIR, EA, and melting point, and in the case of 1, 2, and 4-8, X-ray crystallography...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28430299/effect-of-retreatment-instruments-on-microcrack-formation-a-microcomputed-tomography-study
#5
Mustafa M Koçak, Neslihan Y Çırakoğlu, Sibel Koçak, Baran C Sağlam, Ersan Çiçek, Sevinç A Türker, Emre Bodrumlu
INTRODUCTION: The purpose of this study was to compare the occurrence of microcracks in teeth prepared with different retreatment systems using microcomputed tomography (micro-CT). METHODS: Forty-two freshly extracted mandibular premolar teeth were used. The root canals were instrumented with stainless steel K-files to an apical size of 35/.02 using the balanced-force technique and were obturated using the passive compaction technique. The specimens were divided into 3 experimental groups according to retreatment system used (n = 14): ProTaper Universal retreatment (PTUR), Mtwo retreatment (MTR), or D-RaCe retreatment (D-RC) systems...
April 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28429011/drop-transport-and-positioning-on-lubricant-impregnated-surfaces
#6
Jian Hui Guan, Élfego Ruiz-Gutiérrez, Ben Bin Xu, David Wood, Glen McHale, Rodrigo Ledesma-Aguilar, Gary George Wells
We demonstrate the transport and positioning of water droplets on macro-patterned lubricant-impregnated surfaces. The macro-patterning produces menisci features in the impregnating liquid layer which interact with a droplet via a capillary mechanism similar to the Cheerios effect. These interactions control the droplet motion and positioning on an otherwise completely slippery surface. We present experimental results using a V-shape channel geometry as a model system. The interaction between deformations on the lubricant layer induced by the droplet and the underlying V-shape geometry leads to both local and global equilibrium positions for the droplet within the channel...
April 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28426222/structural-and-dynamical-properties-of-tetra-alkyl-ammonium-bromide-aqueous-solutions-a-molecular-dynamics-simulation-study-using-a-polarizable-force-field
#7
Dengpan Dong, Justin B Hooper, Dmitry Bedrov
Understanding the behavior of aqueous solutions containing tetra-alkyl ammonium (TAA) cations is of great significance in a number of applications, including polymer membranes for fuel cells. In this work, a polarizable force field has been used to preform atomistic molecular dynamics (MD) simulations of aqueous solutions containing tetra-methyl ammonium (TMA) or tetra-butyl ammonium (TBA) cations and Br counterions. Extensive MD simulations of TMA-Br/water and TBA-Br/water systems were conducted as a function of solution composition (ion pair : water molar ratios of 1:10, 1:20, 1:30, 1:63, 1:500) at atmospheric pressure and 298K...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28422241/super-tough-ultra-stretchable-and-strongly-compressive-hydrogels-with-core-shell-latex-particles-inducing-efficient-aggregation-of-hydrophobic-chains
#8
Xiuyan Ren, Chang Huang, Lijie Duan, Baijun Liu, Lvjun Bu, Shuang Guan, Jiliang Hou, Huixuan Zhang, Guanghui Gao
Toughness, strechability and compressibility for hydrogels were ordinarily balanced for their use as mechanically responsive materials. For example, macromolecular microsphere composite hydrogels with chemical crosslinking exhibited excellent compression strength and strechability, but poor tensile stress. Here, a novel strategy for the preparation of a super-tough, ultra-stretchable and strongly compressive hydrogel was proposed by introducing core-shell latex particles (LPs) as crosslinking centers for inducing efficient aggregation of hydrophobic chains...
April 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28422035/-new-therapeutic-schedules-of-sunitinib-current-evidence-regarding-the-2-1-scheme
#9
Ignacio Puche-Sanz, José Francisco Flores-Martín, Fernando Vázquez-Alonso, Juan Moreno-Jiménez, José Manuel Cózar-Olmo
INTRODUCTION: In 2006, sunitinib approval by the FDA was a real revolution for the treatment of metastatic renal cell carcinoma (mRCC). However, considerable rates of dose reductions and therapeutic suppressions with the standard regimen (4:2) have forced the search for new schedule proposals in order to optimize the balance between side effects and oncologic efficacy. Among these new proposals, the 2:1 scheme is the one that has generated more expectations. OBJECTIVE: The objective of this paper is to make a review and critical discussion of current evidence about the new schedules of treatment with sunitinib...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28420973/no-overt-effects-of-a-6-week-exergame-training-on-sensorimotor-and-cognitive-function-in-older-adults-a-preliminary-investigation
#10
Madeleine Ordnung, Maike Hoff, Elisabeth Kaminski, Arno Villringer, Patrick Ragert
Several studies investigating the relationship between physical activity and cognition showed that exercise interventions might have beneficial effects on working memory, executive functions as well as motor fitness in old adults. Recently, movement based video games (exergames) have been introduced to have the capability to improve cognitive function in older adults. Healthy aging is associated with a loss of cognitive, as well as sensorimotor functions. During exergaming, participants are required to perform physical activities while being simultaneously surrounded by a cognitively challenging environment...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28414407/medical-student-teaching-and-recruiting-50-years-of-balancing-two-educational-aims
#11
Benjamin N Schneider, Alexander Chessman, William Toffler, Lara Handler, Beat Steiner, Frances Emily Biagioli
Family medicine (FM) undergraduate medical educators have had two distinct missions, to increase the knowledge, skills, and attitudes of all students while also striving to attract students to the field of family medicine. A five decade literature search was conducted gathering FM curricular innovations and the parallel trends in FM medical student interest. Student interest in FM had a rapid first-decade rise to 14%, a second 1990's surge, followed by a drop to the current plateau of 8-9%. This falls far short of the 30-50% generalist benchmark needed to fill the country's health care needs...
April 2017: Family Medicine
https://www.readbyqxmd.com/read/28413338/the-cross-over-to-magnetostrophic-convection-in-planetary-dynamo-systems
#12
REVIEW
J M Aurnou, E M King
Global scale magnetostrophic balance, in which Lorentz and Coriolis forces comprise the leading-order force balance, has long been thought to describe the natural state of planetary dynamo systems. This argument arises from consideration of the linear theory of rotating magnetoconvection. Here we test this long-held tenet by directly comparing linear predictions against dynamo modelling results. This comparison shows that dynamo modelling results are not typically in the global magnetostrophic state predicted by linear theory...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28412980/arctic-systems-in-the-quaternary-ecological-collision-faunal-mosaics-and-the-consequences-of-a-wobbling-climate
#13
E P Hoberg, J A Cook, S J Agosta, W Boeger, K E Galbreath, S Laaksonen, S J Kutz, D R Brooks
Climate oscillations and episodic processes interact with evolution, ecology and biogeography to determine the structure and complex mosaic that is the biosphere. Parasites and parasite-host assemblages are key components in a general explanatory paradigm for global biodiversity. We explore faunal assembly in the context of Quaternary time frames of the past 2.6 million years, a period dominated by episodic shifts in climate. Climate drivers cross a continuum from geological to contemporary timescales and serve to determine the structure and distribution of complex biotas...
April 17, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28411549/stability-of-knee-ligament-complex-of-thiel-embalmed-cadaver-compared-to-in-vivo-knee
#14
Florian Völlner, Ulrike Pilsl, Benjamin Craiovan, Florian Zeman, Michael Schneider, Michael Wörner, Joachim Grifka, Markus Weber
BACKGROUND: The first biomechanical evaluation of new implants is usually carried out with cadavers. Fixation of Thiel-embalmed cadavers is supposed to preserve the histological structure, colour and consistency of the tissue and has a low risk of infection and toxicity. However, the biomechanical properties of Thiel-fixated tissue are still unknown. The aim of this study was to quantify the effect of the Thiel-embalming method on the elastic properties of the ligament complex of the knee compared to in vivo knees during total knee arthroplasty...
April 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28409417/how-nucleus-mechanics-and-ecm-microstructure-influence-the-invasion-of-single-cells-and-multicellular-aggregates
#15
Chiara Giverso, Alessandro Arduino, Luigi Preziosi
In order to move in a three-dimensional extracellular matrix, the nucleus of a cell must squeeze through the narrow spacing among the fibers and, by adhering to them, the cell needs to exert sufficiently strong traction forces. If the nucleus is too stiff, the spacing too narrow, or traction forces too weak, the cell is not able to penetrate the network. In this article, we formulate a mathematical model based on an energetic approach, for cells entering cylindrical channels composed of extracellular matrix fibers...
April 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28409395/spinal-and-corticospinal-pathways-are-differently-modulated-when-standing-at-the-bottom-and-the-top-of-a-three-step-staircase-in-young-and-older-adults
#16
Johanna Johannsson, Jacques Duchateau, Stéphane Baudry
PURPOSE: This study investigated the modulation of spinal (group Ia afferents) and corticospinal pathways when young (22.7 ± 1.3 years) and older adults (72.2 ± 7.9 years) stood at the bottom and at the top of a three-step staircase equipped with force platforms. METHOD: Changes in submaximal H-reflex amplitude (H 50) and slope of the H-reflex input-output relation (spinal pathway), and in amplitude of motor-evoked potentials (MEP) triggered by transcranial magnetic stimulation (corticospinal pathway) at two intensities (1...
April 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28409085/mechanical-properties-of-spindle-poles-are-symmetrically-balanced
#17
Kazuya Suzuki, Takeshi Itabashi, Shin'ichi Ishiwata
The metaphase spindle is organized for accurate chromosome segregation. One of the fundamental features of the spindle across the species is its symmetrical shape; the spindle consists of two polar arrays of microtubules at both ends. Although it has been suggested that the formation of the bipolar shape requires force balance coordination by molecular motors, i.e., kinesins and dyneins, quantitative analysis for the pole mechanics has not been conducted. Here, we demonstrate that it is not only the shape but also the stiffness and microtubule density of the pairs of pole regions are symmetrically balanced in single spindles self-assembled in Xenopus egg extracts...
2017: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/28408197/a-new-orthodontic-force-system-for-moment-control-utilizing-the-flexibility-of-common-wires-evaluation-of-the-effect-of-contractile-force-and-hook-length
#18
Wei-Jen Lai, Yoshiyuki Midorikawa, Zuisei Kanno, Hiroshi Takemura, Kazuhiro Suga, Kohei Soga, Takashi Ono, Motohiro Uo
BACKGROUND/PURPOSE: The application of an appropriate force system is indispensable for successful orthodontic treatments. Second-order moment control is especially important in many clinical situations, so we developed a new force system composed of a straight orthodontic wire and two crimpable hooks of different lengths to produce the second-order moment. The objective of this study was to evaluate this new force system and determine an optimum condition that could be used in clinics...
April 10, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28407522/physiological-arousal-accompanying-postural-responses-to-external-perturbations-after-stroke
#19
C L Pollock, M G Carpenter, M A Hunt, A Gallina, T M Vieira, T D Ivanova, S J Garland
OBJECTIVE: The purpose of this study was to examine simultaneously the level of physiological arousal and the postural response to external perturbations in people post-stroke compared to age-matched controls to build a more comprehensive understanding of the effect of stroke on postural control and balance self-efficacy. METHODS: Participants stood with each foot on separate force platforms. Ten applications of loads of 2% body weight at the hips perturbed the participant anteriorly under two conditions: investigator-triggered or self-triggered (total 20)...
March 18, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28406968/the-sense-of-balance-in-humans-structural-features-of-otoconia-and-their-response-to-linear-acceleration
#20
Rüdiger Kniep, Dirk Zahn, Jana Wulfes, Leif Erik Walther
We explored the functional role of individual otoconia within the otolith system of mammalians responsible for the detection of linear accelerations and head tilts in relation to the gravity vector. Details of the inner structure and the shape of intact human and artificial otoconia were studied using environmental scanning electron microscopy (ESEM), including decalcification by ethylenediaminetetraacetic acid (EDTA) to discriminate local calcium carbonate density. Considerable differences between the rhombohedral faces of human and artificial otoconia already indicate that the inner architecture of otoconia is not consistent with the point group -3m...
2017: PloS One
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