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Hospital acquired anemia

Jason Brazelton, Robert A Oster, Brandi McCleskey, Jessica Fuller, Jill Adamski, Marisa B Marques
Thrombotic thrombocytopenic purpura (TTP) has >90% mortality without therapeutic plasma exchange (TPE). Despite TPE, approximately 10% of patients still die, presumably from cardiac ischemia. We sought clinical or laboratory parameters associated with death by reviewing the records of all patients hospitalized with acquired TTP in our institution for 10 years, and collect demographics and results for hemoglobin, platelet count, creatinine, lactate dehydrogenase, transaminases, total bilirubin, creatinine kinase (CK), CK-MB, and troponin I...
September 26, 2016: Journal of Clinical Apheresis
Ji Won In, Nuri Lee, Eun Youn Roh, Sue Shin, Kyoung Un Park, Eun Young Song
OBJECTIVES: Aplastic anemia (AA) is characterized by pancytopenia and bone marrow failure, and most acquired AA is an immune-mediated disorder. Regulatory T cells (Tregs) suppressing autoreactive T cells were decreased in AA patients. FoxP3 is a major regulator for the development and function of Tregs. Polymorphism in FoxP3 was shown to be associated with various autoimmune diseases, however, has not yet been studied in AA. In this study, we examined the association between FoxP3 polymorphisms and AA in Korean patients...
October 5, 2016: Hematology (Amsterdam, Netherlands)
Samia Ben Sassi, Nahla Touati, Hela Baccouche, Cyrine Drissi, Neila Ben Romdhane, Fayçal Hentati
OBJECTIVE: Data regarding cerebral venous thrombosis in North Africa are scarce. This study aims to identify the clinical features, risk factors, outcome, and prognosis of cerebral venous thrombosis in Tunisia. METHODS: Data of 160 patients with radiologically confirmed cerebral venous thrombosis, hospitalized in Mongi Ben Hmida National Institute of Neurology (Tunis, Tunisia), were retrospectively collected and analyzed. RESULTS: The mean age was 37...
August 31, 2016: Clinical and Applied Thrombosis/hemostasis
Y Ozier, C Aubron, B-V Nguyen
Hospital-acquired anemia is common, especially in the most critically ill patients. It may be associated with poor patient outcomes. It may result from increased blood loss, impaired red cell production or reduced red cell life span. Multiple associated factors may contribute simultaneously or sequentially to the decrease in hemoglobin level. Some of them are related to the underlying disease and others are iatrogenic. Clinicians should be aware of the importance and consequences of iatrogenic anemia caused by diagnostic blood sampling...
August 22, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Dennis Lund Hansen, Ulrik Malthe Overgaard, Lars Pedersen, Henrik Frederiksen
PURPOSE: The nationwide public health registers in Denmark provide a unique opportunity for evaluation of disease-associated morbidity if the positive predictive values (PPVs) of the primary diagnosis are known. The aim of this study was to evaluate the predictive values of hemolytic anemias registered in the Danish National Patient Register. PATIENTS AND METHODS: All patients with a first-ever diagnosis of hemolytic anemia from either specialist outpatient clinic contact or inpatient admission at Odense University Hospital from January 1994 through December 2011 were considered for inclusion...
2016: Clinical Epidemiology
Kai Zacharowski, Donat R Spahn
Patient blood management (PBM) can be defined in many ways and may consist of hundreds of single measures to improve patient safety. Traditionally, PBM is based on three pillars and defined as (i) optimization of the endogenous red blood cell (RBC) mass through the targeted stimulation of erythropoiesis and the treatment of modifiable underlying disorders; (ii) minimization of diagnostic, interventional, and surgical blood loss to preserve the patient's RBC mass; and (iii) optimization of the patient-specific tolerance to anemia through strict adherence to physiological transfusion thresholds [1-4]...
June 2016: Best Practice & Research. Clinical Anaesthesiology
Habtamu Mulu, Leja Hamza, Fesehaye Alemseged
BACKGROUND: HIV/AIDS predisposes to malnutrition. Malnutrition exacerbates HIV/AIDS progression resulting in increased morbidity and mortality. The magnitude of malnutrition in HIV/AIDS patients has not been well studied in Ethiopian setup. Our objective was to assess the prevalence of malnutrition and associated factors among HIV/AIDS patients admitted to Jimma University Specialized Hospital (JUSH). METHOD: A cross-sectional study was conducted to assess the nutritional status of 109 HIV/AIDS patients admitted from November 2013 to July 2014...
May 2016: Ethiopian Journal of Health Sciences
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No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
A V Budnevsky, I E Esaulenko, E S Ovsyannikov, N B Labzhaniya, E V Voronina, A V Chernov
Community-acquired pneumonia remains a most widespread acute infectious disease of socio-economic significance all over the world. Up to 30% of the patients present with anemia responsible for the unfavourable prognosis and elevated mortality. Not infrequently, anemia is not diagnosed during the hospital stay und therefore remains uncorrected. Severe anemia results in enhanced hypercapnia and slowed maturation of red blood cells in the bone marrow which facilitates the development of ischemic syndrome. Hepcidin, a mediator of inflammation and iron-regulatory hormone, plays an important role in the clinical course of community-acquired pneumonia...
2016: Klinicheskaia Meditsina
T Sreenivas, A R Nataraj, Anand Kumar, Jagdish Menon
PURPOSE: The study was conducted to evaluate clinical and microbiological profile of neonates with septic arthritis and also to assess changing epidemiology in the microbial etiology. METHODS: Twenty-nine neonates (1-28 days of life) presenting to the Department of Orthopaedics with acute septic arthritis were included in the study. This was a descriptive study, and the data were collected during the time of hospital admission. History and clinical examination of the neonates were taken, and diagnosis was made based on clinical and laboratory parameters...
July 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Christopher R Cannavino, Agnes Nemeth, Bartosz Korczowski, John S Bradley, Tanya O'Neal, Alena Jandourek, H David Friedland, Sheldon L Kaplan
BACKGROUND: Community-acquired bacterial pneumonia (CABP) remains a major infection among children, despite the use of pneumococcal vaccination. Ceftaroline fosamil is a broad-spectrum cephalosporin antibiotic with activity against many bacteria, including Streptococcus pneumoniae (both penicillin-nonsusceptible and multidrug-resistant strains) and Staphylococcus aureus (including methicillin-resistant S. aureus). This article describes the safety, tolerability, and effectiveness of ceftaroline fosamil in the treatment of pediatric patients hospitalized with CABP, from a randomized, active-controlled, observer-blinded clinical study (registration number NCT01530763)...
July 2016: Pediatric Infectious Disease Journal
Sadia Sultan, Syed Mohammed Irfan
BACKGROUND: Primary myelodysplastic syndrome (MDS) is an acquired clonal disorder of myeloid progenitor cells, characterized by peripheral cytopenias in the presence of hypercellular marrow with dysplastic features. Our aim was to study the demographical and clinicopathological features of adult Pakistani patients with MDS at disease presentation. MATERIALS AND METHODS: This single centre study was conducted at Liaquat National Hospital and Medical College, extending from January 2010 to December 2014...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Akari Hashimoto, Yuji Kanisawa, Akihito Fujimi, Chisa Nakajima, Naotaka Hayasaka, Shota Yamada, Toshinori Okuda, Shinya Minami, Natsumi Yamauchi, Sari Iwasaki, Akira Suzuki, Junji Kato
A 61-year-old woman with rheumatoid arthritis who was undergoing hemodialysis for end-stage renal failure was transferred to our hospital due to severe thrombocytopenia and anemia. A bone marrow biopsy showed the complete absence of megakaryocytes and erythroblasts. Cyclosporine treatment resulted in the improvement of her megakaryocyte and erythroblast levels, and a decrease in her serum level of anti-c-Mpl (thrombopoietin receptor) antibodies. After this initial improvement, her anemia progressively worsened, despite the continuous administration of immunosuppressive therapy with cyclosporine...
2016: Internal Medicine
Limei Tan, Junping Wang, Fansen Zeng, Yong Zhang, Chunxiao Fang, Chuan Nie, Yi Xu, Jie Yang
OBJECTIVE: To explore the clinical manifestations and laboratory examination characteristics of neonatal dengue fever. METHOD: A retrospective analysis of 12 cases of neonatal dengue fever treated in the Guangdong Women and Children's Hospital and Guangzhou Women and Children's Medical Center was conducted, and related literature was reviewed. RESULT: Twelve cases of neonatal dengue fever included 9 males and 3 females; their age was 30 min after birth to 29 d, the age of onset was 30 min-24 d...
December 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Yuan Zhang, Zhi Guo, Xiao-Dong Liu, Xue-Peng He, Kai Yang, Peng Chen, Hui-Ren Chen
This study aimed to compare the efficacy and safety between haploidentical hematopoietic stem cell transplantation (HHCT) and immunosuppressive therapy (IST) for the treatment of pediatric acquired severe aplastic anemia (SAA). The clinical data of 28 children with SAA treated from June 2010 to October 2014 at our hospital were retrospectively reviewed. Of these patients, 18 were treated with HHCT and 10 with IST. The median follow-up time was 23.5 months (range, 3-52 months). There was no significant difference in overall survival rate between the HHCT group and the IST group (66...
February 11, 2016: American Journal of Therapeutics
Márcia Carolline dos Santos Sousa, Carmen Dea Ribeiro de Paula, Pedro Luiz Tauil, Izelda Maria Carvalho Costa
Epidermolysis bullosa comprises a group of phenotypically different genodermatosis, hereditary or acquired, characterized by skin fragility and subsequent formation of blisters in response to mechanical trauma, and which may also affect mucous membranes. This study aimed to analyze the relation between the nutritional, hematologic, infectious characteristics and the type of epidermolysis bullosa, through a descriptive case study based on data from medical records of 10 patients with epidermolysis bullosa assisted regularly at the Dermatology Clinic of the Hospital Universitário de Brasília...
November 2015: Anais Brasileiros de Dermatologia
A M Lynch, M Respess, A E Boll, M Bozych, M McMichael, D J Fletcher, A M De Laforcade, E A Rozanski
BACKGROUND: Hospital-acquired anemia is commonly described in people but limited information currently is available regarding its prevalence in animals. HYPOTHESIS/OBJECTIVES: Assess the prevalence of hospital-acquired anemia in hospitalized critically ill dogs and cats, and examine its relationship with phlebotomy practices, transfusion administration, and survival to discharge. ANIMALS: Eight hundred and fifty-one client-owned animals (688 dogs and 163 cats)...
January 2016: Journal of Veterinary Internal Medicine
Tohru Inaba, Bunta Shimomoto, Yuri Hirose, Masao Shimotsuma, Akira Nanbu, Toshiaki Komori, Terukazu Nakamura, Yasuhiro Yamashiro, Naohisa Fujita
A 30s male was diagnosed as having the left testicular tumor in 2010. He received the anti-neoplastic chemotherapy, and could achieve the complete remission. But, he relapsed with solitary retroperitoneal lymph node swelling in 2012, and he was referred to our hospital. Laboratory examination on his admission showed the significant increase of fetal hemoglobin (HbF) up to 16.4%. But, neither anemia nor hemolysis was found at that time. Coexistence of therapy-related myeloid neoplasm or HbF production by metastatic lesion was not definite...
May 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
Makoto Moriyama, Takuya Nagata, Isaku Yoshioka, Isaya Hashimoto, Koshi Matsui, Tomoyuki Okumura, Kazuhiro Tsukada
Paroxysmal nocturnal hemoglobinuria (PNH) is acquired hemolytic anemia characterized by symptoms such as anemia and hemoglobinuria. In recent years, eculizumab as an anti-complement (C5) monoclonal antibody has been used for PNH and shown to have marked effects. We performed laparoscopic cholecystectomy in a patient with PNH being treated with eculizumab, and could avoid the risk of perioperative hemolysis and thrombosis. [Patient] The patient was a 48-year-old female who had developed PNH when she was 39 years old...
2015: Surgical Case Reports
Niels D Martin, Dane Scantling
Advances in medicine have significantly improved lives and life spans globally. However, these practices have come with their own set of secondary consequences. Hospital-acquired anemia is one such consequence and is conferred by new medicines, operations, procedures, and tests. In this review, the authors will explore the data on this poorly considered phenomenon and discuss the etiologies, outcomes, and prevention strategies for some of the more prolific causes of hospital-acquired anemia. This study also will review the risks and benefits of treating hospital-acquired anemia...
September 2015: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
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