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https://www.readbyqxmd.com/read/27834746/menopausal-hot-flashes-and-carotid-intima-media-thickness-among-midlife-women
#1
Rebecca C Thurston, Yuefang Chang, Emma Barinas-Mitchell, J Richard Jennings, Doug P Landsittel, Nanette Santoro, Roland von Känel, Karen A Matthews
BACKGROUND AND PURPOSE: There has been a longstanding interest in the role of menopause and its correlates in the development of cardiovascular disease (CVD) in women. Menopausal hot flashes are experienced by most midlife women; emerging data link hot flashes to CVD risk indicators. We tested whether hot flashes, measured via state-of-the-art physiologic methods, were associated with greater subclinical atherosclerosis as assessed by carotid ultrasound. We considered the role of CVD risk factors and estradiol concentrations in these associations...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27745917/prospective-evaluation-of-the-molecular-effects-of-metformin-on-the-endometrium-in-women-with-newly-diagnosed-endometrial-cancer-a-window-of-opportunity-study
#2
Pamela T Soliman, Qian Zhang, Russell R Broaddus, Shannon N Westin, David Iglesias, Mark F Munsell, Rosemarie Schmandt, Melinda Yates, Lois Ramondetta, Karen H Lu
OBJECTIVE: Metformin reduces cancer incidence and improves overall survival in diabetic patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition. We sought to determine the effects of metformin on serum/tumor biomarkers in women with EC. METHODS: In this prospective trial, newly diagnosed EC patients underwent pre-treatment blood draw/endometrial biopsy, were administered oral metformin 850mg daily for ≥7days, and underwent post-treatment blood draw/definitive surgery...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27683872/lifestyle-and-other-factors-explain-one-half-of-the-variability-in-the-serum-25-hydroxyvitamin-d-response-to-cholecalciferol-supplementation-in-healthy-adults
#3
Judy R Rees, Leila A Mott, Elizabeth L Barry, John A Baron, Roberd M Bostick, Jane C Figueiredo, Robert S Bresalier, Douglas J Robertson, Janet L Peacock
BACKGROUND: Many factors have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentrations in observational studies, with variable consistency. However, less information is available on factors affecting the magnitude of changes in serum 25(OH)D resulting from vitamin D supplementation. OBJECTIVE: This study aimed to identify factors associated with the serum 25(OH)D response to supplementation with 1000 IU cholecalciferol/d during the first year of a large, multicenter, randomized, placebo-controlled colorectal adenoma chemoprevention trial...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27604761/lifestyle-predictors-of-oxidant-and-antioxidant-enzyme-activities-and-total-antioxidant-capacity-in-healthy-women-a-cross-sectional-study
#4
Amjad A Mahasneh, Yali Zhang, Hua Zhao, Christine B Ambrosone, Chi-Chen Hong
The aim of this study was to identify demographic and modifiable lifestyle factors that may be related to endogenous oxidant and antioxidant activity measured in blood specimens from putatively healthy women recruited at the Roswell Park Cancer Institute (Buffalo, NY, USA). Total glutathione (TGSH), catalase (CAT), CuZn-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and myeloperoxidase (MPO) activity, and total antioxidant capacity (TAC) were measured in 124 healthy women, and associations with epidemiological factors were tested using general linear models...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27426932/serum-and-retinal-responses-to-three-different-doses-of-macular-carotenoids-over-12-weeks-of-supplementation
#5
James M Stringham, Nicole T Stringham
The macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to have neuroprotective and visual performance benefits once deposited in retinal tissues. The purpose of this 12-week trial was to determine biweekly the absorption kinetics, efficiency of retinal deposition, and effects on the spatial profile of macular pigment for three levels of L + Z + MZ supplement. This study was a double-blind, placebo-controlled 12-week trial. Twenty-eight healthy subjects, aged 18-25 yrs participated...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27426424/associations-between-the-phosphatidylethanol-alcohol-biomarker-and-self-reported-alcohol-use-in-a-sample-of-hiv-infected-outpatient-drinkers-in-western-kenya
#6
Rebecca K Papas, Benson N Gakinya, Michael M Mwaniki, Alfred K Keter, Hana Lee, Michelle P Loxley, Debra A Klein, John E Sidle, Steve Martino, Joyce B Baliddawa, Kathryn L Schlaudt, Stephen A Maisto
BACKGROUND: To counteract the syndemics of HIV and alcohol in Sub-Saharan Africa, international collaborations have developed interventions to reduce alcohol consumption. Reliable and accurate methods are needed to estimate alcohol use outcomes. A direct alcohol biomarker called phosphatidylethanol (PEth) has been shown to validate heavy, daily drinking, but the literature indicates mixed results for moderate and nondaily drinkers, including among HIV-infected populations. This study examined the associations of the PEth biomarker with self-report alcohol use at 2 time points in 127 HIV-infected outpatient drinkers in western Kenya...
August 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27352195/cerebral-perfusion-alterations-and-cognitive-decline-in-critically-ill-sepsis-survivors
#7
Charalampos Pierrakos, Rachid Attou, Laurence Decorte, Dimitrios Velissaris, Antonella Cudia, Philippe Gottignies, Jacques Devriendt, Magda Tsolaki, David De Bels
INTRODUCTION: We investigated the association between cerebral perfusion perturbations in sepsis with possible cognitive decline (CD) after patients' discharge from the intensive care unit (ICU). METHODS: We studied 28 patients with sepsis and Lawton's Instrumental Activities of Daily Living scale (IADL) scores ≥5 who were discharged from a university ICU institution. We evaluated cerebral circulatory parameters (pulsatility index (PI) and cerebral blood flow index (CBFi) was calculated based on the measured velocity of the middle cerebral artery...
June 3, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27251878/bilingual-text4walking-food-service-employee-intervention-pilot-study
#8
Susan Weber Buchholz, Diana Ingram, JoEllen Wilbur, Louis Fogg, Giselle Sandi, Angela Moss, Edith V Ocampo
BACKGROUND: Half of all adults in the United States do not meet the level of recommended aerobic physical activity. Physical activity interventions are now being conducted in the workplace. Accessible technology, in the form of widespread usage of cell phones and text messaging, is available for promoting physical activity. OBJECTIVE: The purposes of this study, which was conducted in the workplace, were to determine (1) the feasibility of implementing a bilingual 12-week Text4Walking intervention and (2) the effect of the Text4Walking intervention on change in physical activity and health status in a food service employee population...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27236808/measuring-hematocrit-in-mice-injected-with-in-vitro-transcribed-erythropoietin-mrna
#9
Azita Josefine Mahiny, Katalin Karikó
In vitro-transcribed (IVT) mRNA encoding therapeutic protein has the potential to treat a variety of diseases by serving as template for translation in the patient. To optimize conditions for such therapy, reporter protein-encoding mRNAs are usually used. One preferred reporter is erythropoietin (EPO), which stimulates erythropoiesis and leads to an increase in hematocrit. Measurement of hematocrit is a fast and reliable method to determine the potency of the in vitro-transcribed EPO mRNA. However, frequent blood draw from mice can increase hematocrit due to blood loss...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27233505/no-correlation-between-serum-markers-and-early-functional-outcome-after-contemporary-tha
#10
Kirsten L Poehling-Monaghan, Michael J Taunton, Atul F Kamath, Robert T Trousdale, Rafael J Sierra, Mark W Pagnano
BACKGROUND: Serum markers of inflammation and muscle damage have shown clinical utility in some areas of medicine, but their value in determining the invasiveness or in predicting the early functional outcomes after total hip arthroplasty (THA) has not been demonstrated. QUESTIONS/PURPOSES: (1) Do serum markers of inflammation/muscle damage predict pain or early functional outcomes after contemporary THA performed through a direct anterior or miniposterior approach? (2) Do early functional outcomes as measured by in-hospital outcomes and clinical milestones differ between a contemporary direct anterior and miniposterior approach for THA? METHODS: Between August 31, 2013, and September 1, 2014, all patients presenting as candidates for THA at our institution who had not already had preoperative blood draws (161) were recruited for this study...
May 27, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27130193/a-week-of-danjiki-buddhist-fasting-ritual-on-cardiometabolic-health-a-case-report
#11
Hirofumi Tanaka, Tsubasa Tomoto, Jun Sugawara
Danjiki is an ascetic traditional fasting ritual in the Japanese Buddhism training. Here we present a case of a 48-year-old man who underwent a 1-week-long Danjiki fasting ritual in a remote Buddhist temple. The daily ritual consisted of waking up at 3:30 am, hiking strenuously in the steep mountains followed by meditations on the rocks, focused calligraphy of religious drawings and documents, recital of Buddhist prayer chanting, and standing under waterfalls while reciting prayers. He was allowed to drink water ad libitum and a cup of carrot juice a day...
September 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27028709/association-of-leptin-with-body-pain-in-women
#12
Jarred Younger, Kristopher Kapphahn, Kathleen Brennan, Shannon D Sullivan, Marcia L Stefanick
Leptin, an appetite-regulatory hormone, is also known to act as a proinflammatory adipokine. One of the effects of increased systemic leptin concentrations may be greater sensitivity to pain. We report the results of two studies examining the association between leptin and pain: a small pilot longitudinal study, followed by a large cross-sectional study. In Study 1, three women with physician-diagnosed fibromyalgia provided blood draws daily for 25 consecutive days, as well as daily self-reported musculoskeletal pain...
July 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/26903049/food-sources-of-dietary-sodium-in-the-japanese-adult-population-the-international-study-of-macro-micronutrients-and-blood-pressure-intermap
#13
Nagako Okuda, Akira Okayama, Katsuyuki Miura, Katsushi Yoshita, Shigeyuki Saito, Hideaki Nakagawa, Kiyomi Sakata, Naoko Miyagawa, Queenie Chan, Paul Elliott, Hirotsugu Ueshima, Jeremiah Stamler
PURPOSE: It is often reported that Na intake levels are higher in Japan than in western countries. Detailed analysis of food intake and its association with Na intake are necessary for supporting further decreases in Na consumption in Japan. We investigated the association between Na and food intake by food group using data from the Japanese participants of the INTERMAP Study. METHOD: Results from the Japanese participants of the INTERMAP Study who did not use antihypertensive medication and/or consume a reduced Na diet were used (531 men and 518 women, aged 40-59 years), obtained from four 24-h dietary recalls and two 24-h urine collections from each participant...
February 22, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/26817716/consumption-of-fish-oil-providing-amounts-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-that-can-be-obtained-from-the-diet-reduces-blood-pressure-in-adults-with-systolic-hypertension-a-retrospective-analysis
#14
RANDOMIZED CONTROLLED TRIAL
Anne M Minihane, Christopher K Armah, Elizabeth A Miles, Jacqueline M Madden, Allan B Clark, Muriel J Caslake, Chris J Packard, Bettina M Kofler, Georg Lietz, Peter J Curtis, John C Mathers, Christine M Williams, Philip C Calder
BACKGROUND: Although many randomized controlled trials (RCTs) have examined the effects of the n-3 (ω-3) fatty acids eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) on blood pressure (BP) and vascular function, the majority have used doses of EPA+DHA of >3 g/d, which are unlikely to be achieved by dietary manipulation. OBJECTIVE: The objective was to examine, by using a retrospective analysis from a multicenter RCT, the impact of recommended EPA+DHA intakes achievable through diet on systolic and diastolic BPs and microvascular function in adults in the United Kingdom...
March 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26656891/implementation-of-later-morning-specimen-draws-to-improve-patient-health-and-satisfaction
#15
REVIEW
Vasundara Ramarajan, Harjinder S Chima, LaWanda Young
Traditionally, morning blood draws are collected by hospital staff from 3:00 AM through 6:00 AM to have the results ready by 9:00 AM for physician rounds. These laboratory results help physicians to make important patient disposition decisions, including discharging patients within the daily hospital cutoff times. However, morning draws can adversely impact patient care due to sleep disruption. In this paper, we describe the systematic implementation of later-morning blood draw times at our large urban hospital...
February 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/26554832/venous-thrombosis-risk-after-cast-immobilization-of-the-lower-extremity-derivation-and-validation-of-a-clinical-prediction-score-l-trip-cast-in-three-population-based-case-control-studies
#16
Banne Nemeth, Raymond A van Adrichem, Astrid van Hylckama Vlieg, Paolo Bucciarelli, Ida Martinelli, Trevor Baglin, Frits R Rosendaal, Saskia le Cessie, Suzanne C Cannegieter
BACKGROUND: Guidelines and clinical practice vary considerably with respect to thrombosis prophylaxis during plaster cast immobilization of the lower extremity. Identifying patients at high risk for the development of venous thromboembolism (VTE) would provide a basis for considering individual thromboprophylaxis use and planning treatment studies. The aims of this study were (1) to investigate the predictive value of genetic and environmental risk factors, levels of coagulation factors, and other biomarkers for the occurrence of VTE after cast immobilization of the lower extremity and (2) to develop a clinical prediction tool for the prediction of VTE in plaster cast patients...
November 2015: PLoS Medicine
https://www.readbyqxmd.com/read/26164619/impact-of-minimizing-diagnostic-blood-loss-in-the-critically-ill
#17
COMPARATIVE STUDY
Heather S Dolman, Kelly Evans, Lisa Hall Zimmerman, Todd Lavery, Alfred E Baylor, Robert F Wilson, James G Tyburski
BACKGROUND: The use of a small-volume phlebotomy tube (SVPT) versus conventional-volume phlebotomy tube (CVPT) has led to a decrease in daily blood loss. Blood loss due to phlebotomy can lead ultimately to decreased rates of anemia and blood transfusions, which can be important in the critically ill patient. METHODS: We compared SVPT vs CVPT retrospectively in critically ill adult patients age ≥18 years admitted to a surgical intensive care unit for ≥48 hours...
October 2015: Surgery
https://www.readbyqxmd.com/read/26163546/long-term-residential-exposure-to-urban-air-pollution-and-repeated-measures-of-systemic-blood-markers-of-inflammation-and-coagulation
#18
Anja Viehmann, Sabine Hertel, Kateryna Fuks, Lewin Eisele, Susanne Moebus, Stefan Möhlenkamp, Michael Nonnemacher, Hermann Jakobs, Raimund Erbel, Karl-Heinz Jöckel, Barbara Hoffmann
BACKGROUND: In several studies, exposure to fine particulate matter (PM) has been associated with inflammation, with inconsistent results. We used repeated measurements to examine the association of long-term fine and ultrafine particle exposure with several blood markers of inflammation and coagulation. METHODS: We used baseline (2000-2003) and follow-up (2006-2008) data from the Heinz Nixdorf Recall Study, a German population-based prospective cohort of 4814 participants...
September 2015: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/26085481/a-multi-ingredient-pre-workout-supplement-is-apparently-safe-in-healthy-males-and-females
#19
Jordan M Joy, Ryan P Lowery, Paul H Falcone, Roxanne M Vogel, Matt M Mosman, Chih-Yin Tai, Laura R Carson, Dylan Kimber, David Choate, Michael P Kim, Jacob M Wilson, Jordan R Moon
BACKGROUND: Pre-workout supplements (PWS) have become increasingly popular with recreational and competitive athletes. While many ingredients used in PWS have had their safety assessed, the interactions when combined are less understood. OBJECTIVE: The purpose of this study was to examine the safety of 1 and 2 servings of a PWS. DESIGN: Forty-four males and females (24.4±4.6 years; 174.7±9.3 cm; 78.9±18.6 kg) from two laboratories participated in this study...
2015: Food & Nutrition Research
https://www.readbyqxmd.com/read/25945698/pregnancy-distress-gets-under-fetal-skin-maternal-ambulatory-assessment-sex-differences-in-prenatal-development
#20
Colleen Doyle, Elizabeth Werner, Tianshu Feng, Seonjoo Lee, Margaret Altemus, Joseph R Isler, Catherine Monk
Prenatal maternal distress is associated with an at-risk developmental profile, yet there is little fetal evidence of this putative in utero process. Moreover, the biological transmission for these maternal effects remains uncertain. In a study of n = 125 pregnant adolescents (ages 14-19), ambulatory assessments of daily negative mood (anger, frustration, irritation, stress), physical activity, blood pressure, heart rate (every 30 min over 24 hr), and salivary cortisol (six samples) were collected at 13-16, 24-27, 34-37 gestational weeks...
July 2015: Developmental Psychobiology
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