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https://www.readbyqxmd.com/read/29617065/relationships-between-self-injurious-behaviors-pain-reactivity-and-%C3%AE-endorphin-in-children-and-adolescents-with-autism
#1
Sylvie Tordjman, George M Anderson, Annaëlle Charrier, Cécile Oriol, Solenn Kermarrec, Roberto Canitano, Michel Botbol, Nathalie Coulon, Corinne Antoine, Sylvie Brailly-Tabard, David Cohen, Hazar Haidar, Séverine Trabado, Michèle Carlier, Guillaume Bronsard, Laurent Mottron
OBJECTIVE: Autism and certain associated behaviors including self-injurious behaviors (SIB) and atypical pain reactivity have been hypothesized to result from excessive opioid activity. The objective of this study was to examine the relationships between SIB, pain reactivity, and β-endorphin levels in autism. METHODS: Study participants were recruited between 2007 and 2012 from day care centers and included 74 children and adolescents diagnosed with autism (according to DSM-IV-TR, ICD-10, and CFTMEA) and intellectual disability...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29614023/genomic-influence-in-the-prevention-of-cardiovascular-diseases-with-a-sterol-based-treatment
#2
Ismael San Mauro Martín, Javier Andrés Blumenfeld Olivares, Eva Pérez Arruche, Esperanza Arce Delgado, María José Ciudad Cabañas, Elena Garicano Vilar, Luis Collado Yurrita
Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women)...
April 3, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29579503/effect-of-peripheral-iv-based-blood-collection-on-catheter-dwell-time-blood-collection-and-patient-response
#3
Deborah F Mulloy, Susan M Lee, Matthew Gregas, Kate E Hoffman, Stanley W Ashley
AIM: To evaluate the effect of daily PIV-based phlebotomy using the PIVO device on PIVC dwell times and replacement rates, as well as the reliability of blood sample collection, and patient response to this method of blood collection. BACKGROUND: Blood draws which are also known as phlebotomy for laboratory analyses are one of the most common experiences for hospitalized patients. When performed by venipuncture, they are often associated with pain and anxiety for patients...
April 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29525040/a-mitochondrial-health-index-sensitive-to-mood-and-caregiving-stress
#4
Martin Picard, Aric A Prather, Eli Puterman, Alexanne Cuillerier, Michael Coccia, Kirstin Aschbacher, Yan Burelle, Elissa S Epel
BACKGROUND: Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood. Chronic stress may induce recalibrations in mitochondria leading to changes either in mitochondrial content per cell, or in mitochondrial functional capacity (i.e., quality). METHODS: Here we present a functional index of mitochondrial health (MHI) for human leukocytes that can distinguish between these two possibilities...
February 3, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29470279/acute-serum-cartilage-biomarker-response-following-walking-and-drop-landing
#5
Matthew S Harkey, J Troy Blackburn, Anthony C Hackney, Michael D Lewek, Randy J Schmitz, Brian Pietrosimone
INTRODUCTION: An in depth understanding of the healthy cartilage response to activities of daily living is needed to better understand the complex relationship between cartilage health and loading. The purpose was to assess the role of loading on the acute serum cartilage oligomeric matrix protein (COMP) response in recreationally active individuals. METHODS: 40 individuals without previous lower extremity injury participated in this repeated measures study in which each participant completed all conditions during independent data collection sessions separated by at least one week...
February 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29462506/evaluation-of-flexible-tacrolimus-drug-concentration-monitoring-approach-in-patients-receiving-extended-release-once-daily-tacrolimus-tablets
#6
Benjamin Philosophe, Nicolae Leca, Patricia M West-Thielke, Timothy Horwedel, Christine Culkin-Gemmell, Kristin Kistler, Daniel R Stevens
The majority of United States kidney transplant patients are treated with tacrolimus, a drug effective in preventing graft rejection, but with a narrow therapeutic range, necessitating close monitoring to avoid increased risks of transplant rejection or toxicity if the tacrolimus concentration is too low or too high, respectively. The trough drug concentration tests are time sensitive; patients treated on a twice-daily basis have blood draws exactly 12 hours after their previous dose. The schedule's rigidity causes problems for both patients and health care providers...
February 20, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29432206/evaluation-of-hematological-alterations-after-therapeutic-use-of-dipyrone-in-healthy-adults-a-prospective-study
#7
Ernane C de Souza, Dalyara M Matos, Milainy R Viana, Marcela C O Alvim, Herval L Bonfante, Alexandre F Pinto, Jorge W L Nascimento
BACKGROUND: Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone. METHODS: The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days...
February 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29373883/the-relation-of-carotid-arteries-intima-media-thickness-with-snoring-and-obstructive-sleep-apnea-in-type-2-diabetes-patients
#8
Leila Ghofraniha, Mahnaz Amini, Yasamin Davoudi, Saeed Eslami, Parvin Layegh, Zahra Lotfi, Farnoush Firouzi, Samaneh Khajehnasiri
In recent decades, the relation of carotid artery intima-media thickness (IMT) as a marker of atherosclerosis with snoring and sleep disorders has been drawing attention. The aim of this study was to evaluate the relation of carotid arteries IMT with snoring in type 2 diabetic patients. This cross-sectional study was performed on type 2 diabetes patients referring to Mashhad University of Medical Sciences' clinics. The stop Bang, Epworth sleepiness scale, and Stanford questionnaires were used for evaluation of daily sleepiness and snoring...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29195999/the-effect-of-raisins-on-biomarkers-of-endothelial-function-and-oxidant-damage-an-open-label-and-randomized-controlled-intervention
#9
Panagiotis T Kanellos, Andriana C Kaliora, Athanasios D Protogerou, Nikolaos Tentolouris, Despina N Perrea, Vaios T Karathanos
Based on the existing data in grapes and wine, the aim of the present study was to investigate the probability that raisins improve clinical features and markers of oxidative stress, inflammation and arterial function in healthy smokers. Thirty-six apparently healthy smokers were recruited to an open-label and randomized, controlled, 4-week prospective intervention. All participants were reported to consume less than the recommended amount of five servings fruits and vegetables daily. Participants in the intervention were instructed to consume raisins equal to five fruit servings (90g/d)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29126422/changes-in-total-and-differential-leukocyte-counts-during-the-clinically-silent-liver-phase-in-a-controlled-human-malaria-infection-in-malaria-na%C3%A3-ve-dutch-volunteers
#10
Marlies E van Wolfswinkel, Marijke C C Langenberg, Linda J Wammes, Robert W Sauerwein, Rob Koelewijn, Cornelus C Hermsen, Jaap J van Hellemond, Perry J van Genderen
BACKGROUND: Both in endemic countries and in imported malaria, changes in total and differential leukocyte count during Plasmodium falciparum infection have been described. To study the exact dynamics of differential leukocyte counts and their ratios, they were monitored in a group of healthy non-immune volunteers in two separate Controlled Human Malaria Infection (CHMI) studies. METHODS: In two CHMI trials, CHMI-a and CHMI-b, 15 and 24 healthy malaria-naïve volunteers, respectively, were exposed to bites of infected mosquitoes, using the P...
November 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29110304/beta-blockers-for-preventing-aortic-dissection-in-marfan-syndrome
#11
REVIEW
Hyun-Kyoung Koo, Kendra Ak Lawrence, Vijaya M Musini
BACKGROUND: Marfan syndrome is a hereditary disorder affecting the connective tissue and is caused by a mutation of the fibrillin-1 (FBN1) gene. It affects multiple systems of the body, most notably the cardiovascular, ocular, skeletal, dural and pulmonary systems. Aortic root dilatation is the most frequent cardiovascular manifestation and its complications, including aortic regurgitation, dissection and rupture are the main cause of morbidity and mortality. OBJECTIVES: To assess the long-term efficacy and safety of beta-blocker therapy as compared to placebo, no treatment or surveillance only in people with Marfan syndrome...
November 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29071662/hemoglobin-concentration-is-associated-with-self-reported-disability-and-reduced-physical-performance-in-a-community-dwelling-population-of-nonagenarians-the-mugello-study
#12
Francesca Cecchi, Silvia Pancani, Federica Vannetti, Roberta Boni, Chiara Castagnoli, Anita Paperini, Guido Pasquini, Francesco Sofi, Raffaele Molino-Lova, Claudio Macchi
People aged 90 and older represent a fast-growing population segment who deserve specific attention and research. Aging is associated with a progressive decrease in hemoglobin concentration, which predicts adverse outcome, such as mortality, morbidity, frailty and disability. Whether this association is independent from increased prevalence of comorbidity, causing both anemia and reduced physical function is yet under debate. The aim of this study is to explore the relationship between hemoglobin concentration and self-reported disability and reduced physical performance in a community dwelling population of nonagenarians...
December 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29059367/nicotine-metabolism-informed-care-for-smoking-cessation-a-pilot-precision-rct
#13
Quinn S Wells, Matthew S Freiberg, Robert A Greevy, Rachel F Tyndale, Suman Kundu, Meredith S Duncan, Stephen King, Elizabeth Scoville, Dawn Beaulieu, Vanessa Gatskie, Hilary A Tindle
Introduction: Varenicline doubles cessation over nicotine replacement therapy (NRT) patch for "normal," but not "slow," nicotine metabolizers, as assessed by the nicotine metabolite ratio (NMR). Metabolism-informed care (MIC) could improve outcomes by matching normal metabolizers with non-nicotine medication (e.g., varenicline) and slow metabolizers with NRT patch. Methods: We conducted a feasibility randomized controlled trial of MIC vs. guideline based care (GBC) among 81 outpatient adult daily smokers with medical comorbidity...
October 14, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29024233/use-of-d-dimer-measurement-to-guide-anticoagulant-treatment-in-recurrent-pregnancy-loss-associated-with-antiphospholipid-syndrome
#14
Shi Hua Bao, Shi Le Sheng, Hong Liao, Qian Zhou, Sophia Twum Frempong, Wei Yan Tu
PROBLEM: To examine whether the level of plasma D-dimer can guide anticoagulant treatment in recurrent pregnancy loss (RPL) associated with antiphospholipid syndrome (APS). METHODS: A total of 1096 RPL women with APS between 2012 and 2015 in a single-center hospital were randomly divided into two groups (group A, 75 mg of low-dose aspirin [LDA] daily; group B, 75 mg of LDA plus 4100 U of low molecular weight heparin [LMWH] subcutaneously daily); 1015 of the total successfully completed the trial...
December 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28936485/a-randomized-controlled-trial-of-lisinopril-to-decrease-lymphoid-fibrosis-in-antiretroviral-treated-hiv-infected-individuals
#15
Leslie R Cockerham, Steven A Yukl, Kara Harvill, Ma Somsouk, Sunil K Joshi, Elizabeth Sinclair, Teri Liegler, Rebecca Hoh, Sophie Lyons, Peter W Hunt, Adam Rupert, Irini Sereti, David R Morcock, Ajantha Rhodes, Claire Emson, Marc K Hellerstein, Jacob D Estes, Sharon Lewin, Steven G Deeks, Hiroyu Hatano
BACKGROUND: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and whether this leads to reduction of HIV RNA and DNA levels. METHODS: Thirty HIV-infected individuals on ART were randomized to lisinopril at 20mg daily or matching placebo for 24 weeks...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28910200/comparison-of-two-%C3%AE-alanine-dosing-protocols-on-muscle-carnosine-elevations
#16
David D Church, Jay R Hoffman, Alyssa N Varanoske, Ran Wang, Kayla M Baker, Michael B La Monica, Kyle S Beyer, Sarah J Dodd, Leonardo P Oliveira, Roger C Harris, David H Fukuda, Jeffrey R Stout
OBJECTIVE: β-alanine (BA) is a nonproteogenic amino acid that combines with histidine to form carnosine. The amount taken orally in individual doses, however, is limited due to symptoms of paresthesia that are associated with higher doses. The use of a sustained-release formulation has been reported to reduce the symptoms of paresthesia, suggesting that a greater daily dose may be possible. The purpose of the present study was to determine whether increasing the daily dose of BA can result in a similar increase in muscle carnosine in a reduced time...
November 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28875865/predictors-and-correlates-of-serum-25-hydroxyvitamin-d-concentrations-in-young-women-results-from-the-safe-d-study
#17
Emma T Callegari, Suzanne M Garland, Alexandra Gorelik, Nicola J Reavley, John D Wark
Vitamin D deficiency is a global public health concern. Studies of serum 25-hydroxyvitamin D (25(OH)D) determinants in young women are limited and few include objective covariates. Our aims were to define the prevalence of vitamin D deficiency and examine serum 25(OH)D correlates in an exploratory study of women aged 16-25 years. We studied 348 healthy females living in Victoria, Australia, recruited through Facebook. Data collected included serum 25(OH)D assayed by liquid chromatography-tandem MS, relevant serum biochemistry, soft tissue composition by dual-energy X-ray absorptiometry, skin melanin density, Fitzpatrick skin type, sun exposure using UV dosimeters and lifestyle factors...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28846633/strawberries-improve-pain-and-inflammation-in-obese-adults-with-radiographic-evidence-of-knee-osteoarthritis
#18
Jace Schell, R Hal Scofield, James R Barrett, Biji T Kurien, Nancy Betts, Timothy J Lyons, Yan Daniel Zhao, Arpita Basu
Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee...
August 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28768341/prediction-model-of-serum-lithium-concentrations
#19
Kazunari Yoshida, Hiroyuki Uchida, Takefumi Suzuki, Masahiro Watanabe, Nariyasu Yoshino, Hitoshi Houchi, Masaru Mimura, Noriyasu Fukuoka
Introduction Therapeutic drug monitoring is necessary for lithium, but clinical application of several prediction strategies is still limited because of insufficient predictive accuracy. We herein proposed a suitable model, using creatinine clearance (CLcr)-based lithium clearance (Li-CL). Methods Patients receiving lithium provided the following information: serum lithium and creatinine concentrations, time of blood draw, dosing regimen, concomitant medications, and demographics. Li-CL was calculated as a daily dose per trough concentration for each subject, and the mean of Li-CL/CLcr was used to estimate Li-CL for another 30 subjects...
August 2, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28665925/neonatal-adaptation-following-intrauterine-antidepressant-exposure-assessment-drug-assay-levels-and-infant-development-outcomes
#20
Megan Galbally, Olav Spigset, Andrew R Johnson, Rolland Kohan, Martha Lappas, Andrew J Lewis
BackgroundAlthough a meta-analysis has confirmed the association between antidepressant exposure in utero and subsequent poor neonatal adaptation, few identified studies included drug levels or standardized measures and only two studies followed up children who developed symptoms beyond infancy.MethodsThe study draws on the Mercy Pregnancy and Emotional Wellbeing Study and reports on 42 women/infant pairs at delivery. In all, 31 women continued to take antidepressants until delivery and 11 ceased earlier in pregnancy...
November 2017: Pediatric Research
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