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https://www.readbyqxmd.com/read/29437518/safety-and-efficacy-concerns-of-autologous-fat-grafting-for-velopharyngeal-insufficiency
#1
Yun S Phua, Mark J Edmondson, Rachel J Kerr, Kirstie A Macgill, Rodrigo P Teixeira, Jonathan A Burge
OBJECTIVE: Autologous fat grafting of the velopharynx has been well described for the treatment of velopharyngeal insufficiency (VPI), with most studies purporting it as a technique with low morbidity useful in the treatment of mild VPI. Prompted by 3 cases of obstructive sleep apnea (OSA) following fat grafting of the velopharynx, we undertook a review of the outcomes of this procedure at our unit. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent autologous fat grafting for VPI at the Royal Children's Hospital Melbourne...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29437510/factors-predicting-hospital-length-of-stay-following-pharyngeal-flap-for-velopharyngeal-insufficiency
#2
Jerry W Chao, Michael J Boyajian, Richard L Amdur, Benjamin J Mitchell, Gary F Rogers, Albert K Oh
OBJECTIVE: Routine hospital admission following pharyngeal flap (PF) to correct velopharyngeal insufficiency (VPI) is the standard at most hospitals. Nevertheless, there is increasing resistance from third-party providers to approve stays longer than a "short stay" (23-hour) observation period. The purpose of the current study was to evaluate length of stay (LOS) and document potential influencing factors following PF. DESIGN: Retrospective chart review...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29437506/speech-and-surgical-outcomes-in-children-with-veau-types-iii-and-iv-cleft-palate-a-comparison-of-internationally-adopted-and-nonadopted-children
#3
Mitchell A Pet, Ryan Dodge, Babette Siebold, Sara Kinter, Jonathan Perkins, Raymond W Tse
OBJECTIVE: This study compares speech and surgical outcomes in internationally adopted and nonadopted patients undergoing cleft palate repair, and examines the influence of age at initial palatoplasty. DESIGN: Retrospective cohort study setting: Tertiary Care Children's Hospital. PATIENTS: 70 international adoptees and 211 nonadoptees with Veau type III and IV clefts (without associated syndrome) repaired at our institution. OUTCOME MEASURES: Outcomes included VPI, compensatory misarticulations, intelligibility, nasal air emission, oronasal fistula, and secondary speech surgery...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29430381/characterization-of-a-glycoside-hydrolase-family-78-%C3%AE-l-rhamnosidase-from-bacteroides-thetaiotaomicron-vpi-5482-and-identification-of-functional-residues
#4
Binchun Li, Yaru Ji, Yanqin Li, Guobin Ding
A putative glycoside hydrolase family 78 α-l-rhamnosidase BtRha78A from Bacteroides thetaiotaomicron VPI-5482 was heterologously over-expressed in Escherichia coli. Enzymatic properties of recombinant BtRha78A were characterized in detail. Recombinant BtRha78A might efficiently hydrolyze p-nitrophenyl α-l-rhamnopyranoside. BtRha78A displayed the highest activity at 60 °C in pH 6.5. BtRha78A exhibited a good pH stability and relatively high thermostability. BtRha78A could be tolerant of a low concentration of alcohols...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29415867/time-course-of-improvement-after-re-repair-procedure-for-vpi-management
#5
Ahmed Elsherbiny, Meghan Amerson, Laura Sconyers, John H Grant
OBJECTIVES: Palatal re-repair aims to improve velar function by retro-positioning the levator veli palatini muscles. The surgery includes extensive dissection, leading to tissue edema and scar formation which may need time to remodel. Together with the change of muscle orientation and tension, it is expected that a period of time is needed to reach the final functional performance. This study attempts to determine how much time is required to reach the optimum performance of the palate after re-repair...
February 5, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29387661/patterns-and-grade-of-velopharyngeal-closure-in-candidates-for-adenotonsillectomy
#6
Mohammad-Waheed El-Anwar, Ezzeddin El-Sheikh, Nasser El-Nakeb
Introduction: The most common type of velopharyngeal valve (VPV) closure is a matter of controversy. The aim of this study was to estimate the most common type of VPV closure, including identification of the type and grade of VPV closure among Egyptian children. Materials and Methods: This study included patients who were candidates for adenotonsillectomy. In these cases, video-nasoendoscopy and speech assessment were performed prior to surgery in addition to otorhinolaryngology examination and preoperative laboratory tests...
January 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29381603/the-impact-of-velopharyngeal-surgery-on-the-polysomnographic-parameters-after-cleft-palate-repair
#7
Mosaad Abdel-Aziz, Ayman Hussien, Ahmed Kamel, Khaled Azooz, Mohamed Fawaz
Velopharyngeal surgical procedures may have adverse effect on the airway of the patients with velopharyngeal insufficiency (VPI). The aim of this study was to evaluate the polysomnographic parameters (PSG) in patients who underwent corrective surgery for treatment of VPI. The study included 39 patients who underwent 1 of 3 velopharyngeal surgical techniques; Furlow palatoplasty (12 patients), pharyngeal flap (18 patients), and sphincter pharyngoplasty (9 patients). The patients were subjected to PSG, and they were considered to have obstructive sleep apnea (OSA) with apnea-hypoapnea index (AHI) >1...
January 29, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29380611/evaluation-of-the-relationship-between-obesity-dental-caries-and-periodontal-disease-in-adolescents
#8
G Vallogini, V Nobili, R Rongo, S De Rosa, F Magliarditi, V D'Antò, A Galeotti
AIM: To assess the prevalence of caries, oral hygiene quality and periodontal disease in a cohort of obese adolescents compared to a control group. MATERIALS AND METHODS: Study Design: cross-sectional study conducted on 204 subjects (age range 10-16 years). Ninety obese subjects (BMI >90) and 114 normal-weight subjects (BMI <75) were visited at the Bambino Gesù Children's Hospital and in a junior high school in Rome, respectively. An ad hoc questionnaire (investigating demographic and oral health behaviour data) was filled in by patients and their caregivers...
December 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29341797/visual-dependence-affects-postural-sway-responses-to-continuous-visual-field-motion-in-individuals-with-cerebral-palsy
#9
Yawen Yu, Richard T Lauer, Carole A Tucker, Elizabeth D Thompson, Emily A Keshner
The current study aimed to explore the impact of visual dependence on sensorimotor coupling of postural sway and visual motion in adults and teens with spastic cerebral palsy (CP). We hypothesized that individuals with CP would exhibit greater magnitudes of sway than healthy individuals, and the presence of visual dependence (VD) would produce instability in the direction of visual motion. Participants stood in a virtual environment in which the visual scene remained static or continuously rotated 30 degree/second in pitch-up or pitch-down...
January 17, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29324922/autologous-free-fat-transfer-in-patients-with-velopharyngeal-insufficiency
#10
Pericles Foroglou, Olga Christina Goula, Antonis Tsimponis, Elena Georgiadou, Efterpi Demiri
AIM: To report our initial experience and preliminary results of autologous free fat transfer to improve speech and hypernasality in patients with velopharyngeal insufficiency (VPI) as a sequela of cleft lip and palate repair. MATERIAL AND METHODS: To date 2 patients with a mean age of 25 years were treated with this method. Both had initially received multiple procedures elsewhere for cleft lip and palate repair. We recorded the number of free fat transfer sessions, anatomical places of placement and volumes injected in-patient stay, occurrence or absence of complications and effectiveness of this operation in terms of clinical speech evaluation, functional velopharyngeal closure measurements and speech improvement percentage by an Ear, Nose and Throat (ENT) specialist...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29305090/a-comprehensive-management-protocol-to-treat-cleft-maxillary-hypoplasia
#11
Sunil Richardson, Shreya Krishna, Rakshit V Khandeparker
AIM: To describe a comprehensive management protocol to treat cleft maxillary hypoplasia specific to the patient's age, degree of hypoplasia and presence or absence of velopharyngeal incompetence (VPI). MATERIALS AND METHODS: A total of 359 patients suffering from cleft maxillary hypoplasia were retrospectively studied from January 2004 till June 2015. Lateral cephalograms were taken to assess the degree of deformity and advancement achieved at three intervals. Patients were treated by four treatment modalities: Facemask therapy, Anterior maxillary advancement, Total maxillary osteogenesis and LeFort I advancement...
December 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29297554/survival-success-of-dental-implants-with-acid-etched-surfaces-a-retrospective-evaluation-after-8-to-10-years
#12
Lélis Gustavo Nicoli, Guilherme José Pimentel Lopes de Oliveira, Beatriz Maria Valério Lopes, Cláudio Marcantonio, Daniela Leal Zandim-Barcelos, Elcio Marcantonio
The aim of this study was to conduct a retrospective evaluation of the survival and success rates of dental implants with acid-etched surfaces after 8-10 years of function. Forty-four patients who received 183 implants 8-10 years ago were evaluated. Clinical examinations were performed around the implants and natural teeth. The following parameters were measured: visible plaque index (VPI), marginal bleeding index (MBI), probing depth (PD), bleeding on probing (BOP) and clinical attachment level (CAL). To considerer an implant as a success case, the following criteria were considered: absence of peri-implant infection and suppuration, absence of implant mobility, absence of persistent pain and dysesthesia and absence of radiolucency around the implant...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29287853/musculo-mucous-web-velum-and-velopharyngeal-dysfunction-associated-with-8q22-1-22-2-microduplication
#13
Mathieu Trudel, Rachel Laframboise, Jacques E Leclerc
This report presents a rare case of isolated non-cleft velopharyngeal dysfunction (VPD). An eight-year-old child presented 1. a phenotypically unique band-gap pattern of the velar musculature with anteroposterior insertion; 2. a mosaic partial trisomy on chromosome 19 as well as microduplications on chromosomes 8 and 22. Following cytogenetic analysis, microduplication on chromosome 8 was found in another member of her family. A family history of VPI with hypernasality and nasal regurgitation was reported over three different generations on the patient's maternal side...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29287850/readability-of-online-patient-education-materials-for-velopharyngeal-insufficiency
#14
Deborah X Xie, Ray Y Wang, Sivakumar Chinnadurai
OBJECTIVE: Evaluate the readability of online and mobile application health information about velopharyngeal insufficiency (VPI). METHODS: Top website and mobile application results for search terms "velopharyngeal insufficiency", "velopharyngeal dysfunction", "VPI", and "VPD" were analyzed. Readability was determined using 10 algorithms with Readability Studio Professional Edition (Oleander Software Ltd; Vandalia, OH). Subgroup analysis was performed based on search term and article source - academic hospital, general online resource, peer-reviewed journal, or professional organization...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29250182/peripheral-lung-adenocarcinomas-harboring-epithelial-growth-factor-receptor-mutations-with-microrna-135b-overexpression-are-more-likely-to-invade-visceral-pleura
#15
Hanbo Le, Xiaoling Wang, Yao Zha, Jie Wang, Wangyu Zhu, Zhinan Ye, Xiaoguang Liu, Haijie Ma, Yongkui Zhang
Lung adenocarcinoma, characterized by its early and aggressive local invasion and high metastatic potential, is the most frequently observed histological type of non-small-cell lung cancer (NSCLC). Visceral pleural invasion (VPI) caused by peripheral lung adenocarcinomas is closely associated with the poor prognosis of patients with NSCLC. The association between VPI and some clinicopathological characteristics has been observed in the past few decades. However, the molecular mechanism of VPI in lung adenocarcinomas is unknown...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29160561/can-overnight-stenting-be-safely-eliminated-following-a-pharyngeal-flap-a-matched-comparison-study
#16
Andre M Wineland, Jareen Meinzen-Derr, Paul Willging
OBJECTIVE: Determine if overnight stenting is warranted after pharyngeal flap for management of velopharyngeal insufficiency (VPI) in pediatric patients METHODS: This is a retrospective age-matched cohort study from a single tertiary pediatric facility. Patients who underwent a posterior pharyngeal flap for VPI from January 1, 2013, to December 31, 2016, were included. Two equal groups were constructed based on when their nasal stents were removed, that is, postoperative day (POD) 0 or POD 1...
November 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29146179/soft-palate-reconstruction-after-radionecrosis-combined-anterolateral-thigh-adipofascial-and-nasoseptal-flaps
#17
Joseph Zenga, Jeffrey D Sharon, Jennifer Gross, Jay Gantz, Patrik Pipkorn
Although radiation-based treatment for nasopharyngeal cancer may achieve excellent long term oncologic results, late effects of therapy may lead to soft tissue radionecrosis and velopharyngeal insufficiency (VPI). Repair of these oro- and nasopharyngeal defects presents a complex reconstructive challenge. We present a case of a long-term survivor treated with chemoradiotherapy for nasopharyngeal cancer who developed progressive dysphagia, velopharyngeal insufficiency, and radionecrosis of the nasopharynx and soft palate, leading to tracheostomy and gastrostomy tube dependence...
November 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29099119/el-an%C3%A3-lisis-molecular-de-la-secuencia-del-genoma-completo-de-aislados-cl%C3%A3-nicos-de-vibrio-cholerae-en-m%C3%A3-xico-en-2013-revela-la-presencia-de-la-cepa-causante-de-la-epidemia-de-hait%C3%A3-en-2010
#18
José Alberto Díaz-Quiñonez
La primera semana de septiembre de 2013, el Sistema Nacional de Vigilancia Epidemiológica identificó dos casos de cólera en Ciudad de México. Los cultivos de ambas muestras se confirmaron como Vibrio cholerae serogrupo O1, serotipo Ogawa, biotipo El Tor. Los análisis iniciales por electroforesis por campos pulsados y por reacción en cadena de la polimerasa indicaron que ambas cepas eran similares, pero diferentes de las previamente reportadas en México. La semana siguiente se identificaron cuatro casos más en una comunidad del Estado de Hidalgo, ubicada a 121 kilómetros al noreste de Ciudad de México...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29068965/single-stage-repair-of-palatal-fistula-and-velopharyngeal-incompetence-by-the-new-l-flap
#19
Mohammad Waheed El-Anwar, Ezzeddin Elsheikh, Sherif Askar
OBJECTIVE: To describe and assess the results of use of the new L-shaped posterior pharyngeal flap for repair of both palatal fistula and velopharyngeal incompetence. METHODS: This study included 10 patients who were diagnosed to have soft palate fistula and persistent velopharyngeal insufficiency (VPI). L-shaped superiorly based pharyngeal flap was harvested from oropharynx and inserted into the soft palate closing the fistula after fistula trimming. The palatal part of the flap (transverse limb) was spread 1 cm horizontally and 1 cm in the anteroposterior direction in soft palate at fistula site closing it without tension...
October 24, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29032918/adults-with-22q11-2-deletion-syndrome-have-a-different-velopharyngeal-anatomy-with-predisposition-to-velopharyngeal-insufficiency
#20
Charles Filip, Davide Impieri, Ingegerd Aagenæs, Corstiaan Breugem, Hans Erik Høgevold, Tone Særvold, Ragnhild Aukner, Kari Lima, Kim Tønseth, Tore G Abrahamsen
AIM: To find out if subjects with 22q11.2 deletion syndrome (DS) have a different velopharyngeal anatomy which could cause velopharyngeal insufficiency (VPI). METHODS: A prospective study of 16 subjects >16 years of age with 22q11.2 DS, without overt cleft palate and without previous VPI surgery, and 48 healthy controls >18 years of age were included in the study. Speech was recorded and scored blindly by two independent senior speech therapists. All 64 individuals had MRI scans, which were analyzed blindly by a consultant radiologist...
September 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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