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https://www.readbyqxmd.com/read/29032918/adults-with-22q11-2-deletion-syndrome-have-a-different-velopharyngeal-anatomy-with-predisposition-to-velopharyngeal-insufficiency
#1
Charles Filip, Davide Impieri, Ingegerd Aagenæs, Corstiaan Breugem, Hans Erik Høgevold, Tone Særvold, Ragnhild Aukner, Kari Lima, Kim Tønseth, Tore G Abrahamsen
AIM: To find out if subjects with 22q11.2 deletion syndrome (DS) have a different velopharyngeal anatomy which could cause velopharyngeal insufficiency (VPI). METHODS: A prospective study of 16 subjects >16 years of age with 22q11.2 DS, without overt cleft palate and without previous VPI surgery, and 48 healthy controls >18 years of age were included in the study. Speech was recorded and scored blindly by two independent senior speech therapists. All 64 individuals had MRI scans, which were analyzed blindly by a consultant radiologist...
September 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29029538/visceral-pleural-invasion-predict-a-poor-survival-among-lung-adenocarcinoma-patients-with-tumor-size-%C3%A2-3cm
#2
Tianxiang Chen, Jizhuang Luo, Rui Wang, Haiyong Gu, Yu Gu, Qingyuan Huang, Yiyang Wang, Jiajie Zheng, Chang Gu, Xufeng Pan, Jun Yang, Yunhai Yang, Heng Zhao
INTRODUCTION: The impact of visceral pleural invasion (VPI) on survival remains controversial for patients with early stage non-small cell lung cancer (NSCLC). This study investigated the survival status of VPI among patients with lymph node-negative lung invasive adenocarcinoma smaller than 3cm. METHODS: We retrospectively reviewed 2537 consecutive patients with pathologic stage I lung invasive adenocarcinoma. All patients had received lobectomy and system lymph nodes resection...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966859/computer-aided-classification-of-sickle-cell-retinopathy-using-quantitative-features-in-optical-coherence-tomography-angiography
#3
Minhaj Alam, Damber Thapa, Jennifer I Lim, Dingcai Cao, Xincheng Yao
As a new optical coherence tomography (OCT) imaging modality, there is no standardized quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell retinopathy (SCR). This study is to demonstrate computer-aided SCR classification using quantitative OCTA features, i.e., blood vessel tortuosity (BVT), blood vessel diameter (BVD), vessel perimeter index (VPI), foveal avascular zone (FAZ) area, FAZ contour irregularity, parafoveal avascular density (PAD). It was observed that combined features show improved classification performance, compared to single feature...
September 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28938802/three-body-interactions-and-the-elastic-constants-of-hcp-solid-4-he
#4
Ashleigh L Barnes, Robert J Hinde
The effect of three-body interactions on the elastic properties of hexagonal close packed solid (4)He is investigated using variational path integral (VPI) Monte Carlo simulations. The solid's nonzero elastic constants are calculated, at T = 0 K and for a range of molar volumes from 7.88 cm(3)/mol to 20.78 cm(3)/mol, from the bulk modulus and the three pure shear constants C0, C66, and C44. Three-body interactions are accounted for using our recently reported perturbative treatment based on the nonadditive three-body potential of Cencek et al...
September 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28905695/description-of-anaerotignum-aminivorans-gen-nov-sp-nov-a-strictly-anaerobic-amino-acid-decomposing-bacterium-isolated-from-a-methanogenic-reactor-and-reclassification-of-clostridium-propionicum-clostridium-neopropionicum-and-clostridium-lactatifermentans-as
#5
Atsuko Ueki, Kazushi Goto, Yoshimi Ohtaki, Nobuo Kaku, Katsuji Ueki
A strictly anaerobic bacterial strain (SH021T) was isolated from a methanogenic reactor. Cells were Gram-stain-positive, motile, straight or slightly curved rods. The optimum temperature for growth was 35 °C, and the optimum pH was 6.1-7.7. The strain was asaccharolytic and utilized amino acids as growth substrates. The strain produced acetate and propionate from l-alanine and l-serine, and propionate and butyrate from l-threonine. Branched-chain amino acids (l-isoleucine, l-leucine and l-valine) were utilized weakly, and isovalerate or isobutyrate was produced...
September 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28895429/effectiveness-of-adenotonsillectomy-and-risk-of-velopharyngeal-insufficiency-in-children-with-prader-willi-syndrome
#6
Reema Padia, Harlan Muntz, Kathleen Pfeffer, Jeremy Meier
OBJECTIVES: (1) Review effectiveness of adenotonsillectomy (T&A) for obstructive sleep apnea (OSA) in children with Prader-Willi syndrome (PW). (2) Examine the incidence of velopharyngeal insufficiency (VPI) after T&A in this population. (3) Compare outcomes of T&A in PW and Trisomy 21 (T21) patients. METHODS: Outcomes after T&A in a PW cohort were retrospectively reviewed and compared to those in patients with T21. RESULTS: The study cohort included 22 PW patients...
September 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28882440/determinants-of-under-immunization-and-cumulative-time-spent-under-immunized-in-a-quebec-cohort
#7
Shauna O'Donnell, Eve Dubé, Bruce Tapiero, Arnaud Gagneur, Margaret K Doll, Caroline Quach
BACKGROUND: Under-immunization refers to a state of sub-optimal protection against vaccine preventable diseases. Vaccine coverage for age may not capture intentional or non-intentional spacing of vaccines in the recommended provincial immunization guidelines. We aimed to identify factors associated with coverage and under-immunization and to determine the number of days during which children were under-immunized during their first 24months of life. METHODS: Secondary analysis of children ≤3years recruited through active surveillance for gastroenteritis from three Quebec pediatric emergency departments from 2012 to 2014...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28846469/randomized-clinical-trial-of-12-and-38-silver-diamine-fluoride-treatment
#8
M H T Fung, D Duangthip, M C M Wong, E C M Lo, C H Chu
This 30-mo randomized clinical trial compared the effectiveness of 2 concentrations (12% or 38%) of silver diamine fluoride (SDF) and 2 periodicity of application (once or twice a year) in arresting cavitated dentin caries in primary teeth. Children aged 3 to 4 y who had at least 1 active cavitated caries lesion were enrolled and randomly allocated into 4 groups for intervention. Group 1 had 12% SDF applied annually (every 12 mo), group 2 had 12% SDF applied semiannually (every 6 mo), group 3 had 38% SDF applied annually, and group 4 had 38% SDF applied semiannually...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28833655/validity-and-reliability-of-the-cohip-sf-in-australian-children-with-orofacial-cleft
#9
Caitlin Mary Agnew, Lyndie Foster Page, Sally Hibbert
AIM: To measure the validity and reliability of the Child Oral Health Impact Profile-Short Form (COHIP-SF) in Australian children with orofacial cleft (OFC) and to evaluate the need for a proxy report. DESIGN: Children with OFC and their proxy completed a COHIP-SF questionnaire. Items were divided into oral health, functional and socio-emotional subscales, and scores on all subscales were compared between and within groups. RESULTS: A total of 222 children (average age 11...
November 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28832562/a-clinically-driven-variant-prioritization-framework-outperforms-purely-computational-approaches-for-the-diagnostic-analysis-of-singleton-wes-data
#10
Zornitza Stark, Harriet Dashnow, Sebastian Lunke, Tiong Y Tan, Alison Yeung, Simon Sadedin, Natalie Thorne, Ivan Macciocca, Clara Gaff, Alicia Oshlack, Susan M White, Paul A James
Rapid identification of clinically significant variants is key to the successful application of next generation sequencing technologies in clinical practice. The Melbourne Genomics Health Alliance (MGHA) variant prioritization framework employs a gene prioritization index based on clinician-generated a priori gene lists, and a variant prioritization index (VPI) based on rarity, conservation and protein effect. We used data from 80 patients who underwent singleton whole exome sequencing (WES) to test the ability of the framework to rank causative variants highly, and compared it against the performance of other gene and variant prioritization tools...
November 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28830642/vector-flow-visualization-of-urinary-flow-dynamics-in%C3%A2-a%C3%A2-bladder-outlet-obstruction-model
#11
Takuro Ishii, Billy Y S Yiu, Alfred C H Yu
Voiding dysfunction that results from bladder outlet (BO) obstruction is known to alter significantly the dynamics of urine passage through the urinary tract. To non-invasively image this phenomenon on a time-resolved basis, we pursued the first application of a recently developed flow visualization technique called vector projectile imaging (VPI) that can track the spatiotemporal dynamics of flow vector fields at a frame rate of 10,000 fps (based on plane wave excitation and least-squares Doppler vector estimation principles)...
August 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28819101/hypotension-in-icu-patients-receiving-vasopressor-therapy
#12
Bryce Yapps, Sungtae Shin, Ramin Bighamian, Jill Thorsen, Colleen Arsenault, Sadeq A Quraishi, Jin-Oh Hahn, Andrew T Reisner
Vasopressor infusion (VPI) is used to treat hypotension in an ICU. We studied compliance with blood pressure (BP) goals during VPI and whether a statistical model might be efficacious for advance warning of impending hypotension, compared with a basic hypotension threshold alert. Retrospective data were obtained from a public database. Studying adult ICU patients receiving VPI at submaximal dosages, we analyzed characteristics of sustained hypotension episodes (>15 min) and then developed a logistic regression model to predict hypotension episodes using input features related to BP trends...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810296/-prognostic-study-of-visceral-pleural-invasion-by-pulmonary-adenocarcinoma-with-tumor-size-%C3%A2-3-cm
#13
T Y Chen, H W Ma, R R Jin, C Xu, H J Hua, G X Song, W M Zhang, Z H Zhang
Objective: To evaluate the relationship between visceral pleural invasion (VPI) and other clinicopathological features in lung adenocarcinoma with tumor size ≤3 cm, and to investigate the impact of VPI on the patients' prognosis. Methods: The clinical and pathological features were retrospectively reviewed in 231 cases of lung adenocarcinoma with the largest diameter of tumor ≤3 cm, following complete resection and systemic lymphadenectomy. VPI was divided into three grades, PL0, PL1 and PL2 according to modified Hammar classification for lung cancer upon elastic fiber staining...
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28804715/former-very-preterm-infants-show-alterations-in-thyroid-function-at-a-preschool-age
#14
Anna Posod, Irena Odri Komazec, Ulrike Pupp Peglow, Dagmar Meraner, Elke Griesmaier, Ursula Kiechl-Kohlendorfer
Preterm birth is frequently associated with altered thyroid hormone levels in the newborn period. Recent data suggest a role of prematurity independent of birth size also in childhood thyroid dysfunction. Whether the high-risk population of former very preterm infants (VPI) is particularly susceptible to thyroid hormone alterations is currently unknown. The aim of the present study was to assess whether former VPI display changes in thyroid hormone status in comparison to term-born controls at a preschool age...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28765714/high-prevalence-of-subclass-specific-binding-and-neutralizing-antibodies-against-clostridium-difficile-toxins-in-adult-cystic-fibrosis-sera-possible-mode-of-immunoprotection-against-symptomatic-c-difficile-infection
#15
Tanya M Monaghan, Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Clifford C Shone, David P Humphreys, K Ravi Acharya, Mark H Wilcox
OBJECTIVES: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C. difficile toxin-specific immunoglobulin (Ig)A, IgG and anti-toxin neutralizing antibodies in the sera of adults with cystic fibrosis, symptomatic C. difficile infection (without cystic fibrosis) and healthy controls. METHODS: Subclass-specific IgA and IgG responses to highly purified whole C...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28727858/association-of-velopharyngeal-insufficiency-with-quality-of-life-and-patient-reported-outcomes-after-speech-surgery
#16
Aditi Bhuskute, Jonathan R Skirko, Christina Roth, Ahmed Bayoumi, Blythe Durbin-Johnson, Travis T Tollefson
Importance: Patients with cleft palate and other causes of velopharyngeal insufficiency (VPI) suffer adverse effects on social interactions and communication. Measurement of these patient-reported outcomes is needed to help guide surgical and nonsurgical care. Objectives: To further validate the VPI Effects on Life Outcomes (VELO) instrument, measure the change in quality of life (QOL) after speech surgery, and test the association of change in speech with change in QOL...
September 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28714631/-velopharyngeal-insufficiency-in-children
#17
Anthony De Buys Roessingh, Oumama El Ezzi, Céline Richard, Céline Béguin, Chantal Zbinden-Trichet, Giorgio La Scala, Igor Leuchter
Velopharyngeal insufficiency (VPI) represents an incomplete closure between the soft palate and the posterior pharyngeal wall. Its etiology can be anatomical (cleft palate), neurologic, or iatrogenic (after adenoidectomy). The evaluation of a VPI begins with a through speech and language assessment and can be complemented by instrumental investigations. VPI treatment relies on its early identification, followed by a specific speech therapy management. Surgery is performed in case of no improvement with speech therapy or in case of an anatomical defect not allowing the child to improve...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28686528/the-vaginal-pressure-inducer-a-new-device-to-test-the-un-pleasurableness-and-tolerance-of-vaginal-pressure-and-the-influence-of-sexual-stimuli
#18
Reinhilde J Melles, Marieke D Dewitte, Moniek M Ter Kuile, Charlie Bonnemayer, Madelon M L Peters
To better understand the impact of sexual stimuli on genital pain, a new instrument was developed: the Vaginal Pressure Inducer (VPI). We administered gradually increasing vaginal pressure with the VPI to sexually functional women while watching a neutral, erotic or explicit sex film. Women had higher unpleasantness thresholds in a sexual context compared to a non-sexual context. Moreover, ratings of pleasurableness were higher in the sexual compared to neutral context and most so during the explicit sexual film...
July 7, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28666574/%C3%AE-independent-through-space-hetero-nuclear-correlation-between-spin-1-2-and-quadrupolar-nuclei-in-solids
#19
Hiroki Nagashima, Aany Sofia Lilly Thankamony, Julien Trébosc, Frédérique Pourpoint, Olivier Lafon, Jean Paul Amoureux
We introduce novel sequences using indirect detection to correlate quadrupolar nuclei and spin-1/2 isotopes, other than (1)H and (19)F. These sequences use γ-encoded symmetry-based RNn(ν) schemes that reintroduce the space component |m| = 1 of the heteronuclear dipolar coupling. These schemes can be applied to the indirectly detected spin in Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) sequence or to the detected isotope in a novel sequence, named Dipolar-mediated Heteronuclear Universal-Quantum Correlation (D-HUQC)...
July 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28663862/quantitative-characteristics-of-sickle-cell-retinopathy-in-optical-coherence-tomography-angiography
#20
Minhaj Alam, Damber Thapa, Jennifer I Lim, Dingcai Cao, Xincheng Yao
Early detection is an essential step for effective intervention of sickle cell retinopathy (SCR). Emerging optical coherence tomography angiography (OCTA) provides excellent three-dimensional (3D) resolution to enable label-free, noninvasive visualization of retinal vascular structures, promising improved sensitivity in detecting SCR. However, quantitative analysis of SCR characteristics in OCTA images is yet to be established. In this study, we conducted comprehensive analysis of six OCTA parameters, including blood vessel tortuosity, vessel diameter, vessel perimeter index (VPI), area of foveal avascular zone (FAZ), contour irregularity of FAZ and parafoveal avascular density...
March 1, 2017: Biomedical Optics Express
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