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https://www.readbyqxmd.com/read/28819101/hypotension-in-icu-patients-receiving-vasopressor-therapy
#1
Bryce Yapps, Sungtae Shin, Ramin Bighamian, Jill Thorsen, Colleen Arsenault, Sadeq A Quraishi, Jin-Oh Hahn, Andrew T Reisner
Vasopressor infusion (VPI) is used to treat hypotension in an ICU. We studied compliance with blood pressure (BP) goals during VPI and whether a statistical model might be efficacious for advance warning of impending hypotension, compared with a basic hypotension threshold alert. Retrospective data were obtained from a public database. Studying adult ICU patients receiving VPI at submaximal dosages, we analyzed characteristics of sustained hypotension episodes (>15 min) and then developed a logistic regression model to predict hypotension episodes using input features related to BP trends...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810296/-prognostic-study-of-visceral-pleural-invasion-by-pulmonary-adenocarcinoma-with-tumor-size-%C3%A2-3-cm
#2
T Y Chen, H W Ma, R R Jin, C Xu, H J Hua, G X Song, W M Zhang, Z H Zhang
Objective: To evaluate the relationship between visceral pleural invasion (VPI) and other clinicopathological features in lung adenocarcinoma with tumor size ≤3 cm, and to investigate the impact of VPI on the patients' prognosis. Methods: The clinical and pathological features were retrospectively reviewed in 231 cases of lung adenocarcinoma with the largest diameter of tumor ≤3 cm, following complete resection and systemic lymphadenectomy. VPI was divided into three grades, PL0, PL1 and PL2 according to modified Hammar classification for lung cancer upon elastic fiber staining...
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28804715/former-very-preterm-infants-show-alterations-in-thyroid-function-at-a-preschool-age
#3
Anna Posod, Irena Odri Komazec, Ulrike Pupp Peglow, Dagmar Meraner, Elke Griesmaier, Ursula Kiechl-Kohlendorfer
Preterm birth is frequently associated with altered thyroid hormone levels in the newborn period. Recent data suggest a role of prematurity independent of birth size also in childhood thyroid dysfunction. Whether the high-risk population of former very preterm infants (VPI) is particularly susceptible to thyroid hormone alterations is currently unknown. The aim of the present study was to assess whether former VPI display changes in thyroid hormone status in comparison to term-born controls at a preschool age...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28765714/high-prevalence-of-subclass-specific-binding-and-neutralizing-antibodies-against-clostridium-difficile-toxins-in-adult-cystic-fibrosis-sera-possible-mode-of-immunoprotection-against-symptomatic-c-difficile-infection
#4
Tanya M Monaghan, Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Clifford C Shone, David P Humphreys, K Ravi Acharya, Mark H Wilcox
OBJECTIVES: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C. difficile toxin-specific immunoglobulin (Ig)A, IgG and anti-toxin neutralizing antibodies in the sera of adults with cystic fibrosis, symptomatic C. difficile infection (without cystic fibrosis) and healthy controls. METHODS: Subclass-specific IgA and IgG responses to highly purified whole C...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28727858/association-of-velopharyngeal-insufficiency-with-quality-of-life-and-patient-reported-outcomes-after-speech-surgery
#5
Aditi Bhuskute, Jonathan R Skirko, Christina Roth, Ahmed Bayoumi, Blythe Durbin-Johnson, Travis T Tollefson
Importance: Patients with cleft palate and other causes of velopharyngeal insufficiency (VPI) suffer adverse effects on social interactions and communication. Measurement of these patient-reported outcomes is needed to help guide surgical and nonsurgical care. Objectives: To further validate the VPI Effects on Life Outcomes (VELO) instrument, measure the change in quality of life (QOL) after speech surgery, and test the association of change in speech with change in QOL...
July 20, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28714631/-velopharyngeal-insufficiency-in-children
#6
Anthony De Buys Roessingh, Oumama El Ezzi, Céline Richard, Céline Béguin, Chantal Zbinden-Trichet, Giorgio La Scala, Igor Leuchter
Velopharyngeal insufficiency (VPI) represents an incomplete closure between the soft palate and the posterior pharyngeal wall. Its etiology can be anatomical (cleft palate), neurologic, or iatrogenic (after adenoidectomy). The evaluation of a VPI begins with a through speech and language assessment and can be complemented by instrumental investigations. VPI treatment relies on its early identification, followed by a specific speech therapy management. Surgery is performed in case of no improvement with speech therapy or in case of an anatomical defect not allowing the child to improve...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28686528/the-vaginal-pressure-inducer-a-new-device-to-test-the-un-pleasurableness-and-tolerance-of-vaginal-pressure-and-the-influence-of-sexual-stimuli
#7
Reinhilde J Melles, Marieke D Dewitte, Moniek M Ter Kuile, Charlie Bonnemayer, Madelon M L Peters
To better understand the impact of sexual stimuli on genital pain, a new instrument was developed: the Vaginal Pressure Inducer (VPI). We administered gradually increasing vaginal pressure with the VPI to sexually functional women while watching a neutral, erotic or explicit sex film. Women had higher unpleasantness thresholds in a sexual context compared to a non-sexual context. Moreover, ratings of pleasurableness were higher in the sexual compared to neutral context and most so during the explicit sexual film...
July 7, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28666574/%C3%AE-independent-through-space-hetero-nuclear-correlation-between-spin-1-2-and-quadrupolar-nuclei-in-solids
#8
Hiroki Nagashima, Aany Sofia Lilly Thankamony, Julien Trébosc, Frédérique Pourpoint, Olivier Lafon, Jean Paul Amoureux
We introduce novel sequences using indirect detection to correlate quadrupolar nuclei and spin-1/2 isotopes, other than (1)H and (19)F. These sequences use γ-encoded symmetry-based RNn(ν) schemes that reintroduce the space component |m| = 1 of the heteronuclear dipolar coupling. These schemes can be applied to the indirectly detected spin in Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) sequence or to the detected isotope in a novel sequence, named Dipolar-mediated Heteronuclear Universal-Quantum Correlation (D-HUQC)...
June 19, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28663862/quantitative-characteristics-of-sickle-cell-retinopathy-in-optical-coherence-tomography-angiography
#9
Minhaj Alam, Damber Thapa, Jennifer I Lim, Dingcai Cao, Xincheng Yao
Early detection is an essential step for effective intervention of sickle cell retinopathy (SCR). Emerging optical coherence tomography angiography (OCTA) provides excellent three-dimensional (3D) resolution to enable label-free, noninvasive visualization of retinal vascular structures, promising improved sensitivity in detecting SCR. However, quantitative analysis of SCR characteristics in OCTA images is yet to be established. In this study, we conducted comprehensive analysis of six OCTA parameters, including blood vessel tortuosity, vessel diameter, vessel perimeter index (VPI), area of foveal avascular zone (FAZ), contour irregularity of FAZ and parafoveal avascular density...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28661514/delivery-room-resuscitation-and-adverse-outcomes-among-very-low-birth-weight-preterm-infants
#10
S Arnon, T Dolfin, B Reichman, R H Regev, L Lerner-Geva, V Boyko, I Litmanovitz
OBJECTIVE: To evaluate risk factors and impact of delivery room cardiopulmonary resuscitation (DR-CPR) on very low birth weight (VLBW) preterm infants. STUDY DESIGN: A national, population-based, observational study evaluating risk factors and short-term neonatal outcomes associated with DR-CPR among VLBW, extremely preterm infants (EPIs, 24 to 27 weeks' gestation) and very preterm infants (VPI, 28 to 31 weeks' gestation) born in 1995 to 2010. RESULTS: Among 17 564 VLBW infants, 636 (3...
June 29, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28653561/incidence-of-secondary-surgery-after-modified-furlow-palatoplasty-a-20-year-single-surgeon-case-series
#11
Stephen R Chorney, Emily Commesso, And Sherard Tatum
Objective To determine the occurrence of velopharyngeal insufficiency (VPI) requiring surgery and fistula repair after primary palatoplasty using a "modified" Furlow technique. Study Design Case series with chart review. Setting Academic multidisciplinary cleft and craniofacial center. Subjects and Methods Children younger than 18 years at presentation, with unrepaired cleft palate, with or without cleft lip, including submucous clefts, who underwent palatoplasty were included. No cleft patients having primary repair were excluded...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28644947/acoustic-rhinometry-for-evaluation-of-velopharyngeal-function-in-preschool-children-post-palatoplasty
#12
Fan Li, Hongtao Wang, Yiyang Chen, Wenli Wu
PURPOSE: To assess the feasibility of acoustic rhinometry for the evaluation of velopharyngeal function in preschool children by detecting changes in nasal cavity volume (NV) and minimal cross-sectional area (MCSA) after palatoplasty. MATERIALS AND METHODS: Sixty-one preschool children with incomplete cleft palate who underwent Sommerlad palatoplasty were examined by acoustic rhinometry. MCSA, distance of the MCSA from the nostril (DMCA), NV, and nasopharyngeal volume (NPV) were measured...
May 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28642158/genetic-diversity-of-environmental-vibrio-cholerae-o1-strains-isolated-in-northern-vietnam
#13
Taichiro Takemura, Kazunori Murase, Fumito Maruyama, Thi Luong Tran, Atsushi Ota, Ichiro Nakagawa, Dong Tu Nguyen, Tu Cuong Ngo, Thi Hang Nguyen, Asako Tokizawa, Masatomo Morita, Makoto Ohnishi, Binh Minh Nguyen, Tetsu Yamashiro
Cholera epidemics have been recorded periodically in Vietnam during the seventh cholera pandemic. Since cholera is a water-borne disease, systematic monitoring of environmental waters for Vibrio cholerae presence is important for predicting and preventing cholera epidemics. We conducted monitoring, isolation, and genetic characterization of V. cholerae strains in Nam Dinh province of Northern Vietnam from Jul 2013 to Feb 2015. In this study, four V. cholerae O1 strains were detected and isolated from 110 analyzed water samples (3...
June 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28639833/predictive-ct-features-of-visceral-pleural-invasion-by-t1-sized-peripheral-pulmonary-adenocarcinomas-manifesting-as-subsolid-nodules
#14
Su Yeon Ahn, Chang Min Park, Yoon Kyung Jeon, Hyungjin Kim, Jong Hyuk Lee, Eui Jin Hwang, Jin Mo Goo
OBJECTIVE: The objective of our study was to determine whether visceral pleural invasion (VPI) of T1-sized peripheral pulmonary adenocarcinomas manifesting as subsolid nodules (SSNs) abutting the pleural surface or associated with pleural tags can be predicted. MATERIALS AND METHODS: Our study population consisted of 188 T1-sized peripheral pulmonary adenocarcinomas that appeared as SSNs (24 pure ground-glass nodules [GGNs] and 164 part-solid nodules) and underwent surgical resection between January 2007 and December 2013...
June 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28583513/health-related-quality-of-life-in-patients-with-cleft-palate-validity-and-reliability-of-the-vpi-effects-on-life-outcomes-velo-questionnaire-translated-to-dutch
#15
Laura Bruneel, Kristiane Van Lierde, Kim Bettens, Paul Corthals, Esther Van Poel, Evelien De Groote, Hannah Keppler
BACKGROUND: Disease-specific health-related quality of life (HRQOL) questionnaires provide the clinician with important information regarding the impact of the disease on functioning and well-being. For patients with velopharyngeal insufficiency (VPI), the VPI Effects on Life Outcomes (VELO) questionnaire was developed and validated in English by Skirko et al. (2012). However, a valid and reliable Dutch translation of this questionnaire is not available yet. METHODS: The English questionnaire was translated to Dutch following a forward-backward translation procedure...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28582304/surgical-outcomes-for-speech-surgery-in-22q11-2-deletion-syndrome-the-dilemma-of-persistent-velopharyngeal-insufficiency-after-pharyngeal-flap-operation
#16
Ryan D Wagner, Erik M Wolfswinkel, Edward P Buchanan, David Y Khechoyan
INTRODUCTION: The majority of patients with 22q11.2 deletion syndrome suffer from velopharyngeal insufficiency (VPI). Patients with 22q11.2 deletion syndrome (22qDS) commonly present with a large central velopharyngeal gap in the setting of poor velar and pharyngeal wall motion. The posterior pharyngeal flap is considered the most effective technique to treat VPI in this complex patient group. This study aims to critically evaluate success rates of surgical management of VPI in 22qDS patients and discuss options for management of a failed posterior pharyngeal flap (PPF) with persistent VPI...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28582294/autologous-fat-injection-for-treatment-of-velopharyngeal-insufficiency
#17
Evan Nigh, Gustavo A Rubio, Jeffery Hillam, Misha Armstrong, Luca Debs, Seth R Thaller
BACKGROUND: Management of velopharyngeal insufficiency (VPI) has traditionally involved surgical repair to improve speech. Posterior pharyngeal augmentation using injectable synthetic materials has been advocated. However, outcomes have been equivocal. More recently, autologous fat injection (AFI) has been advocated for correction of mild to moderate VPI. However, long-term efficacy and safety of this procedure remain unsettled. METHODS: A systematic review of the literature was performed...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28557376/comparison-between-tapered-and-cylindrical-implants-in-the-posterior-regions-of-the-mandible-a-prospective-randomized-split-mouth-clinical-trial-focusing-on-implant-stability-changes-during-early-healing
#18
Janine Waechter, Marina de Matos Madruga, Luiz Carlos do Carmo Filho, Fábio Renato Manzolli Leite, André Ribeiro Schinestsck, Fernanda Faot
BACKGROUND: Companies affirm that tapered implants show adequate initial stability, while their installation in the lower arch is uncommon in clinical practice. PURPOSE: To compare the clinical outcomes of tapered and cylindrical implants and to study their effect on bone site characteristics and peri-implant health during healing. MATERIALS AND METHODS: The implant site dimensions were assessed by linear measurements using CBCT prior to the installation of 40 implants in the posterior mandible (20 tapered and 20 cylindrical)...
August 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28543219/prognostic-value-of-visceral-pleural-invasion-in-non-small-cell-lung-cancer-a-propensity-score-matching-study-based-on-the-seer-registry
#19
Xiaodong Yang, Fenghao Sun, Li Chen, Mengkun Shi, Yu Shi, Zongwu Lin, Mingxiang Feng, Cheng Zhan, Wei Jiang, Qun Wang
BACKGROUND AND OBJECTIVES: Visceral pleural invasion (VPI) is considered a poor prognostic factor in non-small cell lung cancer (NSCLC). We aimed to analyze the effect of VPI on cancer-specific survival, using propensity score matching (PSM) based on the Surveillance, Epidemiology, and End Results database. METHODS: We identified 9901 patients with T1-2N0-2M0 who received segmentectomy, lobectomy, or pneumonectomy. Ten covariates were included in PSM. The effect of VPI on survival was assessed, stratified by nodal status and tumor size...
May 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28484235/extent-of-visceral-pleural-invasion-affects-prognosis-of-resected-non-small-cell-lung-cancer-a-meta-analysis
#20
Ting Wang, Chengya Zhou, Qinghua Zhou
Visceral pleural invasion (VPI) has been known to be an adverse prognostic factor in non-small cell lung cancer (NSCLC). However, the prognostic significance of extent of VPI (PL0, PL1 and PL2) remains controversial. We conduct a meta-analysis to summarize available evidence on this topic. PubMed, EMBASE, OVID and The Cochrane Library were searched for published studies from inception to May 9, 2016. A total of 16 studies were included in meta-analysis. Our results showed that patients with PL1 or PL2 had poorer overall survival compared with PL0 (HR = 1...
May 8, 2017: Scientific Reports
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