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Hepatic microcirculation

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https://www.readbyqxmd.com/read/27894918/laser-speckle-contrast-imaging-and-oxygen-to-see-for-assessing-microcirculatory-liver-blood-flow-changes-following-different-volumes-of-hepatectomy
#1
Chong Hui Li, Xin Lan Ge, Ke Pan, Peng Fei Wang, Yi Nan Su, Ai Qun Zhang
OBJECTIVE: Portal hyperperfusion after extended hepatectomy or small-for-size liver transplantation may induce organ dysfunction and failure. This study was designed to monitor and characterize the hepatic microcirculatory perfusion following different volumes of hepatectomy in rats by using laser speckle contrast image (LSCI) and Oxygen to See (O2C), a spectrometric device. METHODS: The microcirculatory liver blood flow of the rats that underwent 68%, 85% and 90% hepatectomy (68PH, 85PH and 90PH) was monitored with LSCI and O2C before and following the hepatectomy...
November 25, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27799962/protective-effects-of-adenosine-receptor-agonist-in-a-cirrhotic-liver-resection-model
#2
Emil Iskandarov, Pramod Kadaba Srinivasan, Wang Xin, Christian Bleilevens, Mamdouh Afify, Astrit Hamza, Lai Wei, Koichiro Hata, Boyukkishi Agayev, Rene Tolba
OBJECTIVES: To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on a bile-duct-ligated cirrhotic liver resection model in rats. METHODS: Male Wistar rats were allotted into 3 groups (n = 7 per time-point): the control group, the bile duct ligation + CGS21680 group (BDL + CGS), and the bile duct ligation group (BDL). Biliary cirrhosis had been previously induced by ligature of the common bile duct in the BDL + CGS and BDL groups. After 2 weeks, the animals underwent partial hepatectomy (50%)...
August 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27792046/ivabradine-attenuates-the-microcirculatory-derangements-evoked-by-experimental-sepsis
#3
Marcos L Miranda, Michelle M Balarini, Daniela S Balthazar, Lorena S Paes, Maria-Carolina S Santos, Eliete Bouskela
BACKGROUND: Experimental data suggest that ivabradine, an inhibitor of the pacemaker current in sinoatrial node, exerts beneficial effects on endothelial cell function, but it is unclear if this drug could prevent microcirculatory dysfunction in septic subjects, improving tissue perfusion and reducing organ failure. Therefore, this study was designed to characterize the microcirculatory effects of ivabradine on a murine model of abdominal sepsis using intravital videomicroscopy. METHODS: Twenty-eight golden Syrian hamsters were allocated in four groups: sham-operated animals, nontreated septic animals, septic animals treated with saline, and septic animals treated with ivabradine (2...
October 28, 2016: Anesthesiology
https://www.readbyqxmd.com/read/27672274/haemoxygenase-modulates-cytokine-induced-neutrophil-chemoattractant-in-hepatic-ischemia-reperfusion-injury
#4
Niteen Tapuria, Sameer Junnarkar, Mahmoud Abu-Amara, Barry Fuller, Alexander M Seifalian, Brian R Davidson
AIM: To investigate the hepatic microcirculatory changes due to Haemoxygenase (HO), effect of HO inhibition on remote ischemic preconditioning (RIPC) and modulation of CINC. METHODS: Eight groups of animals were studied - Sham, ischemia reperfusion injury (IRI) the animals were subjected to 45 min of hepatic ischemia followed by three hours of reperfusion, RIPC (remote ischemic preconditioning) + IRI group, remote ischemic preconditioning in sham (RIPC + Sham), PDTC + IR (Pyridodithiocarbamate, HO donor), ZnPP + RIPC + IRI (Zinc protoporphyrin prior to preconditioning), IR-24 (45 min of ischemia followed by 24 h of reperfusion), RIPC + IR-24 (preconditioning prior to IR)...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27634415/delayed-liver-regeneration-in-c3h-hej-mice-possible-involvement-of-haemodynamic-and-structural-changes-in-the-hepatic-microcirculation
#5
Muhamad Marlini, Ayako Mabuchi, Beth L Mallard, Ngatiman Hairulhisyam, Sachiko Akashi-Takamura, Jacquie L Harper, Antony M Wheatley
What is the central question of this study? The liver regenerative process is complex and involves a sequence of signalling events, but the possible involvement of structural and haemodynamic changes in vivo during this process has never been explored. What is the main finding and its importance? Normal sinusoidal blood flow and velocity are crucial for a normal regenerative response, and delays in these haemodynamic events resulted in impaired liver regeneration in lipopolysaccharide-insensitive, C3H/HeJ mice...
December 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27508607/-op-1d-09-liver-damage-due-to-diabetes-involves-multiple-pathways-and-induces-microcirculation-alterations-the-effect-of-metformin-plus-insulin-treatment
#6
A Daliry, R Rangel Silvares, E N G da Silva Pereira, E E Ilaquita Flores, V Estato, P A Reis, I José da Silva, M P Machado, H C de Castro F Neto, E Tibiriça
OBJECTIVE: As several studies have shown a link between T1D and liver disease we explored the hepatic alterations due to diabetes and the modulation of this complication by the metformin adjunct therapy. DESIGN AND METHOD: Fifty five Wistar rats were divided in three groups: control (CTL, n = 20), high-fat diet/streptozotocin induced diabetic (DM, n = 20) and diabetic treated with metformin plus insulin (DM + Met + Ins, n = 15). The biochemical parameters (%HbA1c, cholesterol, fructosamine, triglycerides, total proteins, bilirubin, urea, uric acid, and ALT, AST, ALP, GGT, and amylase activities) were analyzed by spectrophotometry...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27475883/targeting-the-transsulfuration-h2s-pathway-by-fxr-and-gpbar1-ligands-in-the-treatment-of-portal-hypertension
#7
REVIEW
Stefano Fiorucci, Eleonora Distrutti
Cirrhosis is a end-stage disease of the liver in which fibrogenesis, angiogenesis and distortion of intrahepatic microcirculation lead to increased intrahepatic resistance to portal blood flow, a condition known as portal hypertension. Portal hypertension is maintained by a variety of molecular mechanisms including sinusoidal endothelial cells (LSECs) hyporeactivity, activation of hepatic stellate cells (HSCs), reduction in hepatic endothelial nitric oxide synthase (eNOS) activity along with increased eNOS-derived NO generation in the splanchnic and systemic circulations...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27443832/evaluation-of-liver-function-and-electroacupuncture-efficacy-of-animals-with-alcoholic-liver-injury-by-the-novel-imaging-methods
#8
Dong Zhang, Xiao-Jing Song, Shun-Yue Li, Shu-You Wang, Bing-Jun Chen, Xiao-Dong Bai, Li-Mei Tang
Imaging methods to evaluate hepatic microcirculation (HM) and liver function (LF) by directly monitoring overall liver tissue remain lacking. This study establish imaging methods for LF that combines Laser speckle perfusion imaging (LSPI) and in vivo optical imaging (IVOI) technologies to investigate changes of hepatic microcirculation and reserve function in the animals gavaged with 50% ethanol (15 ml/kg·bw) for a model of acute alcoholic liver injury (ALI), and for evaluation of electroacupuncture (EA) effect...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27427346/the-treatment-of-infected-femoral-artery-pseudoaneurysms-secondary-to-drug-abuse-11%C3%A2-years-of-experience-at-a-single-institution
#9
Jiehua Qiu, Weimin Zhou, Wei Zhou, Xinhua Tang, Qingwen Yuan, Xianhua Zhu, Yujin Yang, Jixin Xiong
BACKGROUND: The purpose of our study is to analyze the methods of treating infected femoral artery pseudoaneurysms (IFAPs), and also to identify the most appropriate method, especially for patients with a long history of drug abuse. METHODS: A retrospective chart review of 88 consecutive IFAPs secondary to drug abuse between 2003 and 2014 was performed. Outpatient clinic charts were reviewed, as well as inpatient and anesthesia records. All patients had undergone a computer tomography angiography or contrast computer tomography to confirm their diagnosis...
July 15, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27381700/combined-therapy-with-metformin-and-insulin-attenuates-systemic-and-hepatic-alterations-in-a-model-of-high-fat-diet-streptozotocin-induced-diabetes
#10
Raquel Rangel Silvares, Evelyn Nunes Goulart da Silva Pereira, Edgar Eduardo Ilaquita Flores, Vanessa Estato, Patrícia Alves Reis, Igor José da Silva, Marcelo Pelajo Machado, Hugo Caire de Castro Faria Neto, Eduardo Tibiriça, Anissa Daliry
In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Met + Ins). Biochemical and cardiometabolic parameters were analysed by spectrophotometry. Intravital microscopy was used to study the hepatic microcirculation. In the liver tissue, real-time PCR was used to analyse oxidative stress enzymes, inflammatory markers and receptors for advanced glycation end products (AGE) (RAGE) gene expression...
June 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27342868/functional-integrity-of-the-chimeric-humanized-mouse-liver-enzyme-zonation-physiologic-spaces-and-hepatic-enzymes-and-transporters
#11
Edwin C Y Chow, Jason Z Ya Wang, Holly P Quach, Hui Tang, David C Evans, Albert P Li, Jose Silva, K Sandy Pang
Chimeric mouse liver models are useful in vivo tools for human drug metabolism studies; however, liver integrity and the microcirculation remain largely uninvestigated. Hence, we conducted liver perfusion studies to examine these attributes in FRGN [Fah(-/-), Rag2(-/-), and Il2rg(-/-), NOD strain] livers (control) and chimeric livers repopulated with mouse (mFRGN) or human (hFRGN) hepatocytes. In single-pass perfusion studies (2.5 ml/min), outflow dilution profiles of noneliminated reference indicators ((51)Cr-RBC, (125)I-albumin, (14)C-sucrose, and (3)H-water) revealed preservation of flow-limited distribution and reduced water and albumin spaces in hFRGN livers compared with FRGN livers, a view supported microscopically by tightly packed sinusoids...
September 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27326313/mechanisms-of-adaptation-of-the-hepatic-vasculature-to-the-deteriorating-conditions-of-blood-circulation-in-liver-cirrhosis
#12
REVIEW
Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev, Dmitry Vladimirovich Belov
PubMed, EMBASE, Orphanet, MIDLINE, Google Scholar and Cochrane Library were searched for articles published between 1983 and 2015. Relevant articles were selected by using the following terms: "Liver cirrhosis", "Endothelial dysfunction", "Sinusoidal remodeling", "Intrahepatic angiogenesis" and "Pathogenesis of portal hypertension". Then the reference lists of identified articles were searched for other relevant publications as well. Besides gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules, the complex morphofunctional rearrangement of the hepatic microvascular bed and intrahepatic angiogenesis also play important roles in hemodynamic disturbances in liver cirrhosis...
June 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27293456/the-effects-of-taoren-honghua-herb-pair-on-pathological-microvessel-and-angiogenesis-associated-signaling-pathway-in-mice-model-of-ccl4-induced-chronic-liver-disease
#13
Shengyan Xi, Lifeng Yue, Mengmeng Shi, Ying Peng, Yangxinzi Xu, Xinrong Wang, Qian Li, Zhijun Kang, Hanjing Li, Yanhui Wang
Chronic liver disease is one of the most common diseases that threaten human health. Effective treatment is still lacking in western medicine. Semen Persicae (Taoren) and Flos Carthami (Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber. The aim of our study is to investigate the potential mechanisms of Taoren-Honghua Herb Pair (THHP) in murine model of chronic liver disease caused by Carbon Tetrachloride (CCl4). Mice were randomly divided into seven groups: (1) blank, (2) model, (3) control (colchicine, 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27221724/effects-of-contrast-enhanced-ultrasonography-in-monitoring-hepatic-microcirculation-after-rat-liver-ischemia-reperfusion-injury
#14
Yun-Fei Zhang, Hong Li, Bao-Hui Zhang, Xiu-Bin Fang
OBJECTIVES: Our objective was to evaluate the effects of contrast-enhanced ultrasonography in monitoring microcirculation after rat liver ischemia-reperfusion injury. MATERIALS AND METHODS: Male Wistar rats (n = 36) were divided into sham-operated and ischemia-reperfusion groups. Rats in the ischemia-reperfusion groups underwent normothermic liver ischemia for 15 minutes followed by 1, 6, or 24 hours of reperfusion. At different time points, contrast-enhanced ultrasonography was performed to determine peak intensity in monitoring hepatic microcirculation...
June 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27190791/ischaemic-markers-in-acute-hepatic-injury
#15
Suchismita Panda, Sushanta Kumar Jena, Rachita Nanda, Manaswini Mangaraj, Parsuram Nayak
INTRODUCTION: Hepatic injury of varied aetiology may progress to Acute Liver Failure (ALF). Compromised microcirculation is thought to be a deciding factor of hepatic hypoxia may be involved in disease progression that needs early detection. Ischaemia markers like serum Ischaemia- modified albumin (IMA), ALT-LDH ratio and ALT-LDH index have been suggested for its detection at early stage. AIM: To find out the association of Ischaemia markers like serum IMA, ALT-LDH ratio and ALT-LDH index in acute hepatic injury cases...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27182154/thrombin-activation-and-liver-inflammation-in-advanced-hepatitis-c-virus-infection
#16
REVIEW
Emilio González-Reimers, Geraldine Quintero-Platt, Candelaria Martín-González, Onán Pérez-Hernández, Lucía Romero-Acevedo, Francisco Santolaria-Fernández
Hepatitis C virus (HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles...
May 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27139375/evaluation-of-perfusion-quantification-methods-with-ultrasound-contrast-agents-in-a-machine-perfused-pig-liver
#17
M Averkiou, C P Keravnou, M L Izamis, E Leen
Purpose: To evaluate dynamic contrast-enhanced ultrasound (DCEUS) as a tool for measuring blood flow in the macro- and microcirculation of an ex-vivo machine-perfused pig liver and to confirm the ability of DCEUS to accurately detect induced flow rate changes so that it could then be used clinically for monitoring flow changes in liver tumors. Materials and Methods: Bolus injections of contrast agents in the hepatic artery (HA) and portal vein (PV) were administered to 3 machine-perfused pig livers. Flow changes were induced by the pump of the machine perfusion system...
May 3, 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27107572/inhibition-of-pathological-angiogenesis-of-chinese-medicine-against-liver-fibrosis
#18
Ping Liu
Pathological angiogenesis of liver which includes liver sinusoidal capillarization due to lose of fenestraes of liver sinusoidal endothelial cells (LSECs) and formation of new vascular, is a crucial mechanism responsible for origination and development of liver fifibrosis and closely involves in the development of cirrhosis and hepatic cancer. Anti-neovascularization medicine such as sorafenib can decrease portosystemic shunts, improve splanchnic hyperdynamic circulation, lower portal hypertension, while it can not be applied in clinic due to its serious toxic and side reactions...
August 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27095270/ultrastructure-of-the-liver-microcirculation-influences-hepatic-and-systemic-insulin-activity-and-provides-a-mechanism-for-age-related-insulin-resistance
#19
Mashani Mohamad, Sarah Jayne Mitchell, Lindsay Edward Wu, Melanie Yvonne White, Stuart James Cordwell, John Mach, Samantha Marie Solon-Biet, Dawn Boyer, Dawn Nines, Abhirup Das, Shi-Yun Catherine Li, Alessandra Warren, Sarah Nicole Hilmer, Robin Fraser, David Andrew Sinclair, Stephen James Simpson, Rafael de Cabo, David George Le Couteur, Victoria Carroll Cogger
While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called 'fenestrations' are essential for insulin transfer across the liver sinusoidal endothelium and that age-related loss of fenestrations causes an impaired insulin clearance and hyperinsulinemia, induces hepatic insulin resistance, impairs hepatic insulin signaling, and deranges glucose homeostasis...
August 2016: Aging Cell
https://www.readbyqxmd.com/read/26820153/thalidomide-improves-the-intestinal-mucosal-injury-and-suppresses-mesenteric-angiogenesis-and-vasodilatation-by-down-regulating-inflammasomes-related-cascades-in-cirrhotic-rats
#20
Tzu-Hao Li, Chia-Chang Huang, Ying-Ying Yang, Kuei-Chuan Lee, Shie-Liang Hsieh, Yun-Cheng Hsieh, Lin Alan, Han-Chieh Lin, Shou-Dong Lee, Chang-Youh Tsai
BACKGROUND AND AIMS: By blocking TNFα-related effects, thalidomide not only inhibits hepatic fibrogenesis but improves peripheral vasodilatation and portal hypertension in cirrhotic rats. Nonetheless, the investigation of thalidomide's effects on splanchnic and collateral microcirculation has been limited. Our study explored the roles of intestinal and mesenteric TNFα along with inflammasome-related pathway in relation to cirrhosis and the splanchnic/collateral microcirculation. METHODS: Using in vivo and in vitro approaches, mechanisms of the effects of thalidomide on intestinal and mesenteric inflammatory, vasodilatory and angiogenic cascades-related abnormalities were explored in cirrhotic rats that had received 1-month thalidomide (C-T) treatment...
2016: PloS One
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