keyword
MENU ▼
Read by QxMD icon Read
search

Hepatic microcirculation

keyword
https://www.readbyqxmd.com/read/29880798/in-situ-splitting-after-selective-partial-portal-vein-ligation-or-simultaneous-hepatic-artery-ligation-promotes-liver-regeneration
#1
Li-Bin Yao, Chong-Hui Li, Xiao-Juan Wu, Xue-Dong Wang, Xin-Lan Ge, Ai-Qun Zhang, Xiao-Cheng Zhu, Yong Shao, Jia-Hong Dong
This study seeks to compare the impact of selective partial portal vein ligation (PPVL) or the combination of simultaneous hepatic artery ligation (PPVAL) with in situ splitting (ISS) on liver regeneration and injury. Rats were randomized into three groups; namely: selective PVL, PPVL + ISS and PPVAL + ISS. The changes in hepatic hemodynamics, liver regeneration and hepatocytic injury were examined. Blood flow to the left portal branch and the microcirculation of the left median lobe after PPVL or PPVAL was significantly reduced...
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29808906/sted-microscopy-a-simplified-method-for-liver-sinusoidal-endothelial-fenestrae-analysis
#2
Julie Di Martino, Patrice Mascalchi, Philippe Legros, Sabrina Lacomme, Etienne Gontier, Paulette Bioulac-Sage, Charles Balabaud, Violaine Moreau, Frédéric Saltel
BACKGROUND: Liver sinusoidal endothelial cells (LSECs) possess fenestrae, open transcellular pores with an average diameter of 100nm. These fenestrae allow for the exchange between blood and hepatocytes. Alterations in their number or diameter in liver diseases have important implications for hepatic microcirculation and function. Although decades of studies, fenestrae are still observed into fixed cells and we have poor knowledge of their dynamics. RESULTS: Using stimulated emission depletion (STED) super-resolution microscopy, we have established a faster and simplest method to observe and quantify fenestrae...
May 29, 2018: Biology of the Cell
https://www.readbyqxmd.com/read/29707583/ultrasonographic-characterization-of-the-db-db-mouse-an-animal-model-of-metabolic-abnormalities
#3
Francesco Faita, Nicole Di Lascio, Chiara Rossi, Claudia Kusmic, Anna Solini
The availability of an animal model able to reliably mirror organ damage occurring in metabolic diseases is an urgent need. These models, mostly rodents, have not been fully characterized in terms of cardiovascular, renal, and hepatic ultrasound parameters, and only sparse values can be found in literature. Aim of this paper is to provide a detailed, noninvasive description of the heart, vessels, liver, and kidneys of the db/db mouse by ultrasound imaging. Sixteen wild type and thirty-four db/db male mice (11-week-old) were studied...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29691495/mechanisms-and-treatment-of-organ-failure-in-sepsis
#4
REVIEW
Christophe Lelubre, Jean-Louis Vincent
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the management and treatment of patients and for the development of potential new therapies. In clinical practice, six major organ systems - the cardiovascular (including the microcirculation), respiratory, renal, neurological, haematological and hepatic systems - can be assessed and monitored, whereas others, such as the gut, are less accessible...
July 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29593573/-rho-a-fraction-from-rhodiola-crenulate-ameliorates-hepatic-steatosis-in-mice-models
#5
Qin Yi, Puyang Sun, Juan Li, Siming Kong, Jinying Tian, Xuechen Li, Yanan Yang, Peicheng Zhang, Yuying Liu, Jingyan Han, Xiaolin Zhang, Fei Ye
The prevalence of non-alcoholic fatty liver disease (NAFLD), which is developed from hepatic steatosis, is increasing worldwide. However, no specific drugs for NAFLD have been approved yet. To observe the effects of Rho , a fraction from Rhodiola crenulate , on non-alcoholic hepatic steatosis, three mouse models with characteristics of NAFLD were used including high-fat diet (HFD)-induced obesity (DIO) mice, KKAy mice, and HFD combined with tetracycline stimulated Model-T mice. Hepatic lipid accumulation was determined via histopathological analysis and/or hepatic TG determination...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29511679/prostaglandin-e1-preconditioning-attenuates-liver-ischemia-reperfusion-injury-in-a-rat-model-of-extrahepatic-cholestasis
#6
Feng Xu, Xiaolin Liu, Chao Wang, Chaoliu Dai
The aim of this study is to explore the hepatoprotective effect of intraportal prostaglandin E1 (PGE1) on liver ischemia reperfusion (IR) injury using an extrahepatic cholestatic model, observing oxidative stress markers, proinflammatory factors, apoptotic marker proteins, and an adhesion molecule. The extrahepatic cholestatic model was induced by common bile duct ligation. After seven days, rats were subjected to ischemia by Pringle maneuver for 15 min, followed by 1, 6, or 24 h of reperfusion. Prostaglandin E1 (PGE group) or normal saline (NS group) was continuously infused from 15 min before liver ischemia to 1 h after reperfusion...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29505662/exogenous-melatonin-protects-small-for-size-liver-grafts-by-promoting-monocyte-infiltration-and-releases-interleukin-6
#7
Zhuolun Song, Bostjan Humar, Anurag Gupta, Eleonora Maurizio, Nathalie Borgeaud, Rolf Graf, Pierre-Alain Clavien, Yinghua Tian
Defective regeneration of small-for-size (SFS) liver remnants and partial grafts remains a key limiting factor in the application of liver surgery and transplantation. Exogenous melatonin (MLT) has protective effects on hepatic ischemia-reperfusion injury (IRI), but its influence on graft regeneration is unknown. The aim of the study is to investigate the role of MLT in IRI and graft regeneration in settings of partial liver transplantation. We established three mouse models to study hepatic IRI and regeneration associated with partial liver transplantation: (I) IR+PH group: 60 minutes liver ischemia (IR) plus 2/3 hepatectomy (PH); (II) IR+exPH group: 60 minutes liver IR plus extended hepatectomy (exPH) associated with the SFS syndrome; (III) SFS-LT group: Arterialized 30% SFS liver transplant...
March 5, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29452205/impaired-cerebral-microcirculation-induced-by-ammonium-chloride-in-rats-is-due-to-cortical-adenosine-release
#8
Peter Nissen Bjerring, Esben Jannik Bjerrum, Fin Stolze Larsen
BACKGROUND & AIMS: Liver failure results in hyperammonaemia, impaired regulation of cerebral microcirculation, encephalopathy, and death. However, the key mediator that alters cerebral microcirculation remains unidentified. In this study we show that topically applied ammonium significantly increases periarteriolar adenosine tone on the brain surface of healthy rats and is associated with a disturbed microcirculation. METHODS: Cranial windows were prepared in anaesthetized Wistar rats...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29433876/autogenous-hepatic-tissue-transplantation-into-the-omentum-in-a-novel-ectopic-liver-regeneration-murine-model
#9
Francisco Igor Macedo, Joseph J Eid, Milessa Decker, Barry Herschman, Edsa Negussie, Vijay K Mittal
BACKGROUND: Liver regeneration involves hyperplasia and hypertrophy of hepatic cells. The capacity of macroscopic liver tissue to regenerate in ectopic sites is unknown. We aim to develop a novel in vivo model of ectopic liver survivability and regeneration and assess its functionality. METHODS: Adult male Sprague-Dawley rats (n = 23) were divided into four groups: (1) single-stage (SS) group, wedge liver resection was performed, and the parenchyma was directly implanted into the omentum; (2) double-stage (DS) group, omentum pedicle was transposed over the left hepatic lobe followed by wedge liver resection along with omental flap; (3) Biogel + DS group, rats received intraperitoneal injection of inert polymer particles prior to DS; (4) Biogel + DS + portal vein ligation (PVL) group, Biogel + DS rats underwent subsequent PVL...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29368124/origins-of-portal-hypertension-in-nonalcoholic-fatty-liver-disease
#10
REVIEW
Gyorgy Baffy
Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis has been identified as a critical determinant of this process. However, there is evidence that portal venous pressure may begin to rise in the earliest stages of NAFLD when fibrosis is far less advanced or absent. The biological and clinical significance of these early changes in sinusoidal homeostasis remains unclear...
March 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29328026/clinical-efficacy-of-s-adenosylmethionine-in-patients-with-non-alcoholic-steatohepatitis-and-chronic-kidney-disease-i-ii-stage
#11
A Antoniv, N Antofiychuk, T Danylyshina, I Trefanenko, V Shuper
The article presents a theoretical generalization of the results of the clinical efficacy of S-adenosylmethionine in patients with non-alcoholic steatohepatitis (NASH) in comorbidity with obesity and chronic kidney disease (CKD) of the 1st-2nd stages. The objective of the article was to determine the likely effect of S-adenosylmethionine and Meldonium on the clinical course of non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD) of the I-II stages. We examined 75 patients with NASH with comorbid obesity I degree and CKD I and II dgrees...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29282572/arterioportal-shunting-splanchnic-capillary-perfusion-and-the-effects-of-colloids-during-capnoperitoneum-in-neonatal-and-adolescent-pigs
#12
J F Kuebler, N Schukfeh, G Vieten, W A Osthaus, D Huber, N Dennhard, R Suempelmann, B M Ure, M L Metzelder
BACKGROUND: Clinical and experimental data indicate that neonates are sensitive to the CO2 pneumoperitoneum. An impaired splanchnic perfusion during laparoscopy in adults has been reported. We recently confirmed that intravenous colloids improve macrocirculatory function in neonates. We aimed to determine the impact of CO2 pneumoperitoneum on the perfusion of splanchnic organs in the young including effects of colloid application. METHODS: Male piglets (n = 25) were divided into four groups: (1) neonatal controls, (2) neonates with crystalloid restitution, (3) neonates with colloidal restitution, and (4) adolescents with crystalloid restitution...
December 27, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29274380/the-nox1-isoform-of-nadph-oxidase-is-involved-in-dysfunction-of-liver-sinusoids-in-nonalcoholic-fatty-liver-disease
#13
Misaki Matsumoto, Jia Zhang, Xueqing Zhang, Junjie Liu, Joy X Jiang, Kanji Yamaguchi, Akiyuki Taruno, Masato Katsuyama, Kazumi Iwata, Masakazu Ibi, Wenhao Cui, Kuniharu Matsuno, Yoshinori Marunaka, Yoshito Itoh, Natalie J Torok, Chihiro Yabe-Nishimura
The increased production of reactive oxygen species (ROS) has been postulated to play a key role in the progression of nonalcoholic fatty liver disease (NAFLD). However, the source of ROS and mechanisms underlying the development of NAFLD have yet to be established. We observed a significant up-regulation of a minor isoform of NADPH oxidase, NOX1, in the liver of nonalcoholic steatohepatitis (NASH) patients as well as of mice fed a high-fat and high-cholesterol (HFC) diet for 8 weeks. In mice deficient in Nox1 (Nox1KO), increased levels of serum alanine aminotransferase and hepatic cleaved caspase-3 demonstrated in HFC diet-fed wild-type mice (WT) were significantly attenuated...
February 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29251575/enhancing-hepatic-microcirculation-in-postoperative-hepatic-failure-with-intra-arterial-recombinant-tissue-plasminogen-activator-treatment
#14
Sukru Oguz, Serkan Tayar, Serdar Topaloglu, Adnan Calik, Hasan Dinc, M Halil Ozturk
Postoperative hepatic failure is one of the most severe complications after liver resection. Treatment protocols have varied from medical support to liver transplant. Here, we describe the clinical course of an 18-year-old female patient with postoperative hepatic failure. The combined use of intra-arterial tissue plasminogen activator infusion and concurrent liver support facilities resulted in successful treatment of postoperative hepatic failure. The role of thrombolytic treatment for postoperative hepatic failure may include future placement in routine treatment protocols, as seen in liver transplant...
December 18, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29210030/pharmacologic-prevention-of-variceal-bleeding-and-rebleeding
#15
REVIEW
Anna Baiges, Virginia Hernández-Gea, Jaime Bosch
BACKGROUND: Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of bleeding from gastroesophageal varices has been one of the main therapeutic goals since the advent of the first effective therapies for portal hypertension. AIM: This review deals with the present day state-of-the-art pharmacological prevention of variceal bleeding in primary and secondary prophylaxis...
February 2018: Hepatology International
https://www.readbyqxmd.com/read/29187232/long-term-continuous-renal-replacement-therapy-and-anticoagulation-with-citrate-in-critically-ill-patients-with-severe-liver-dysfunction
#16
Matthias Klingele, Theresa Stadler, Danilo Fliser, Timo Speer, Heinrich V Groesdonk, Alexander Raddatz
BACKGROUND: As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual influence of hepatic function on citrate-associated complications during long-term CRRT. METHODS: In a retrospective study conducted between January 2009 and November 2012, all cases of dialysis therapy performed in the interdisciplinary surgical intensive care unit were analysed...
November 29, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29103979/comparison-of-microvascular-perfusion-evaluation-among-ivim-dwi-ct-perfusion-imaging-and-histological-microvessel-density-in-rabbit-liver-vx2-tumors
#17
Jing-Lei Li, Wei-Tao Ye, Zai-Yi Liu, Li-Fen Yan, Wei Luo, Xi-Ming Cao, Changhong Liang
OBJECT: To explore microcirculation features with intravoxel incoherent motion (IVIM) and to compare IVIM with CT perfusion imaging (CTPI) and microvessel density (MVD). MATERIALS AND METHODS: Hepatic CTPI and IVIM were performed in 16 rabbit liver VX2 tumor models. Hepatic arterial perfusion (HAP), hepatic arterial perfusion index (HPI), Blood flow (BF), and blood volume (BV) from CTPI were measured. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*) from IVIM were measured...
February 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29065724/microcirculatory-disturbances-and-cellular-changes-during-progression-of-hepatic-steatosis-to-liver-tumors
#18
Marie Liebig, Alireza Hassanzada, Malte Kämmerling, Berit Genz, Brigitte Vollmar, Kerstin Abshagen
Non-alcoholic fatty liver disease is closely associated with metabolic syndrome and comprises a pathological spectrum of liver disease ranging from steatosis to steatohepatitis and can progress to fibrosis/cirrhosis and hepatocellular carcinoma. In 2013, a mouse model was described that mimics non-alcoholic fatty liver disease progression from steatohepatitis to tumors in a short time span and with high incidence. As microcirculatory disturbances play a crucial role in liver disease, the suitability of the steatosis-inflammation-tumor model for microcirculatory studies was assessed...
January 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28917579/microcirculation-in-the-murine-liver-a-computational-fluid-dynamic-model-based-on-3d-reconstruction-from-in-vivo-microscopy
#19
Monica Piergiovanni, Elena Bianchi, Giada Capitani, Irene Li Piani, Lucia Ganzer, Luca G Guidotti, Matteo Iannacone, Gabriele Dubini
The liver is organized in hexagonal functional units - termed lobules - characterized by a rather peculiar blood microcirculation, due to the presence of a tangled network of capillaries - termed sinusoids. A better understanding of the hemodynamics that governs liver microcirculation is relevant to clinical and biological studies aimed at improving our management of liver diseases and transplantation. Herein, we built a CFD model of a 3D sinusoidal network, based on in vivo images of a physiological mouse liver obtained with a 2-photon microscope...
October 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28883542/longitudinal-micro-ultrasound-assessment-of-the-ob-ob-mouse-model-evaluation-of-cardiovascular-renal-and-hepatic-parameters
#20
N Di Lascio, C Kusmic, F Stea, F Lenzarini, C Barsanti, A Leloup, F Faita
BACKGROUND/OBJECTIVES: Obesity is reaching epidemic proportions and is associated with increased risk factors for cardiovascular disease. Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. Aim of this study was to provide a micro-ultrasound (μUS) longitudinal evaluation of the ob/ob mouse model in terms of cardiovascular effects, consequences for renal microcirculation and liver fat accumulation. SUBJECTS/METHODS: Sixteen wild-type (wt) and eleven ob/ob male mice were studied at 8 (T0 ) and 25 (T1 ) weeks of age with a μUS system (Vevo2100) and B-mode and Doppler images were acquired...
March 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
keyword
keyword
31244
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"