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https://www.readbyqxmd.com/read/29793140/effectiveness-of-a-voluntary-family-befriending-service-a-mixed-methods-evaluation-using-the-donabedian-model
#1
S V Gentry, E F J Powers, N Azim, M Maidrag
OBJECTIVES: Voluntary befriending schemes operate in many countries, promoting public health by supporting vulnerable individuals and families. Use of third sector and voluntary services to complement health and social care provision is increasingly important globally in the context of economic and demographic challenges, but the evidence base around such collaborations is limited. This article reports the results of operational evaluation research seeking to use robust routine work to generate transferable findings for use by those commissioning and providing services...
May 21, 2018: Public Health
https://www.readbyqxmd.com/read/29793126/effect-of-manual-therapy-versus-proprioceptive-neuromuscular-facilitation-in-dynamic-balance-mobility-and-flexibility-in-field-hockey-players-a-randomized-controlled-trial
#2
Gemma V Espí-López, Susana López-Martínez, Marta Inglés, Pilar Serra-Añó, Marta Aguilar-Rodríguez
OBJECTIVES: To compare the effectiveness of a specific Manual Therapy (MT) protocol applied to field hockey players (FHP), versus a Proprioceptive Neuromuscular Facilitation (PNF) protocol, in the improvement of dynamic balance, active range of movement and lumbar flexibility one-week and four-weeks after the treatment. DESIGN: Randomized controlled trial. Participants were assigned to 2 groups: MT and PNF. 30 min' sessions were performed once a week for three weeks...
April 22, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29792886/t-grasp-a-targeted-grasp-for-assessing-neuronal-connectivity
#3
Harold K Shearin, Casey D Quinn, Robert D Mackin, Ian S Macdonald, R Steven Stowers
BACKGROUND: Understanding how behaviors are generated by neural circuits requires knowledge of the synaptic connections between the composite neurons. Methods for mapping synaptic connections, such as electron microscopy and paired recordings, are labor intensive and alternative methods are thus desirable. NEW METHOD: Development of a targeted GFP Reconstitution Across Synaptic Partners(GRASP) method, t-GRASP, for assessing neural connectivity is described. RESULTS: Numerous different pre-synaptic and post-synaptic/dendritic proteins were tested for enhancing the specificity of GRASP signal to synaptic regions...
May 21, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29792800/effects-of-enhanced-flexibility-and-pore-size-distribution-on-adsorption-induced-deformation-of-mesoporous-materials
#4
Andrei Kolesnikov, Nikolaj Georgi, Yury A Budkov, Jens Möllmer, Jorg Hofmann, Juergen Adolphs, Roger Gläser
We present a new model of adsorption-induced deformation of mesoporous solids. The model is based on a simplified version of Local Density Functional Theory in the framework of solvation free energy. Instead of density, which is treated as constant here, we used the film thickness and pore radius as order parameters. This allows us to obtain a self-consistent system of equations describing simultaneously the processes of gas adsorption and adsorbent deformation, as well as conditions for capillary condensation and evaporation...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29792726/i-like-them%C3%A2-will-they-like-me-evidence-for-the-role-of-the-ventrolateral-prefrontal-cortex-during-mismatched-social-appraisals-in-anxious-youth
#5
Ashley R Smith, Eric E Nelson, Brent I Rappaport, Daniel S Pine, Ellen Leibenluft, Johanna M Jarcho
OBJECTIVE: Socially anxious adolescents report distress during social decision-making, wherein their favorable view of peers directly conflicts with their expectation to be viewed negatively by peers; a phenomenon we refer to as "mismatch bias." The present study utilizes a novel paradigm with dynamic social stimuli to explore the correlates of mismatch biases in anxious and healthy youth. METHOD: The behavioral and neural correlates of mismatch biases were assessed in healthy (N = 17) and anxious (N = 14) youth during functional MRI...
May 24, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29792681/protein-based-electronic-skin-akin-to-biological-tissues
#6
Minsik Jo, Kyungtaek Min, Biswajit Roy, Sookyoung Kim, Sangmin Lee, Ji-Yong Park, Sunghwan Kim
Human skin provides an interface that transduces external stimuli into electrical signals for communication with the brain. There has been considerable effort to produce soft, flexible, and stretchable electronic skin (E-skin) devices. However, common polymers cannot imitate human skin perfectly due to their poor biocompatibility, biofunctionality, and permeability to many chemicals and biomolecules. Herein, we report on highly flexible, stretchable, conformal, molecule-permeable, and skin-adhering E-skins that combine a metallic nanowire (NW) network and silk protein hydrogel...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792478/acculturation-in-the-discourse-of-immigrants-and-receiving-community-members-results-from-a-cross-national-qualitative-study
#7
Angela Fedi, Terri Mannarini, Anne Brodsky, Alessia Rochira, Sara Buckingham, Lindsay Emery, Surbhi Godsay, Jill Scheibler, Anna Miglietta, Silvia Gattino
This study explores the bidirectional and interactional process of acculturation from the perspectives of immigrants and receiving community members (RCMs). Our aim was to understand the experiences and interactions of different ethno-cultural groups and their impact on the functioning and dynamics of multicultural communities. We conducted a cross-national, cross-cultural study of acculturation processes, using interviews collected across two countries (Italy: urban regions of Torino and Lecce; U.S.: Baltimore/Washington corridor) and three distinct groups of immigrants-Moroccans and Albanians in Italy and Latin Americans in the United States-and RCMs in Italy and the United States...
May 24, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29792463/terrorist-teams-as-loosely-coupled-systems
#8
Matthias Spitzmuller, Guihyun Park
Acts of terrorism can be harrowing and cause extensive damage, yet they occur far too frequently. How do terrorist groups organize and coordinate their attacks? What makes those groups simultaneously cohesive and flexible in a hostile environment? Different academic disciplines have contributed to a better understanding of the proliferation of terrorist acts in recent years. With very few exceptions, however, extant psychological research on terrorism has almost exclusively focused on the individual terrorist...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792432/new-basis-set-for-the-evaluation-of-specific-rotation-in-flexible-biological-molecules-in-solution
#9
Angelika Baranowska-Laczkowska, Krzysztof Z Łączkowski, Christian Henriksen, Berta Fernandez
A detailed theoretical investigation of specific rotation is carried out in solution for nine flexible molecules of biological importance. Systematic search for the main conformers is followed by time-dependent density functional theory (TD-DFT) calculations of specific rotation employing a wide range of basis sets. Due to conformational flexibility of the compounds under study, the possibility of basis set size reduction without deterioration of the results is investigated. The increasing size (d-)aug-cc-pVXZ (X=D, T, Q) bases of Dunning et al...
May 24, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29792328/transforming-nanofibers-to-woven-nanotextiles-for-vascular-application
#10
John Joseph, Aarya G Krishnan, Aleena M Cherian, Balasubramoniam K Rajagopalan, Rajesh Jose, Praveen Varma, Vijayakumar Maniyal, Sivanarayanan Balakrishnan, Shantikumar V Nair, Deepthy Menon
This study investigated the unique properties, fabrication technique and vascular applications of woven nanotextiles made from low strength nanoyarns, which are bundles of thousands of nanofibers. An innovative robotic system was developed to meticulously interweave nanoyarns in longitudinal and transverse directions, resulting in a flexible, but strong woven product. This is the only technique for producing seamless nanotextiles in tubular form from nanofibers. The porosity and mechanical properties of nanotextiles could be substantially tuned by altering the number of nanoyarns per unit area...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29792104/association-of-hip-and-foot-factors-with-patellar-tendinopathy-jumper-s-knee-in-athletes
#11
Luciana D Mendonça, Juliana M Ocarino, Natália F N Bittencourt, Luciana G Macedo, Sérgio T Fonseca
Study Design Clinical measurement, cross-sectional. Background Investigations on the causes of patellar tendinopathy (PT) should consider impairments at the hip and foot/ankle since they are known to influence movement patterns and affect patellar tendon loading. Objectives To investigate, by means of CART analysis, impairments of the hip and foot/ankle that are associated with PT in volleyball and basketball athletes. Methods One-hundred and ninety athletes were assessed for impairments of the hip and foot/ankle including: shank-forefoot alignment (SFA), ankle dorsiflexion range of motion (DF ROM), iliotibial band flexibility, passive hip internal rotation (IR) ROM, and hip external rotator (ER) and hip abductor isometric strength...
May 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29792074/lessons-learned-conducting-a-multi-center-trial-with-a-military-population-the-tinnitus-retraining-therapy-trial
#12
Roberta W Scherer, Leonora D Sensinger, Benigno Sierra-Irizarry, Craig Formby
Background The Tinnitus Retraining Therapy Trial (TRTT), a randomized, placebo-controlled, multi-center trial, evaluated the efficacy of tinnitus retraining therapy and its individual components, tinnitus-specific educational counseling and sound therapy versus the standard of care, in military practice to improve study participants' quality of life. The trial was conducted at six US military hospitals to take advantage of the greater prevalence of tinnitus in the military population. Methods During the trial, various challenges arose that were uniquely related to the military setting...
May 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29792066/capabilities-of-next-generation-patch-pump-improved-precision-instant-occlusion-detection-and-dual-hormone-therapy
#13
Forrest W Payne, Bradley Ledden, Greg Lamps
Insulin pumps allow patients to attain better blood glucose control with more lifestyle flexibility. Their size and cost, however, limit their usefulness. Current CSII pumps are bulky, intrusive, and expensive. SFC Fluidics is addressing these problems by developing a new type of wearable patch pump based on the patented electro-chemiosmotic (ECO) microfluidic pumping technology. This nonmechanical pumping technology allows accurate and precise delivery of very small amounts of insulin and/or other drugs, including concentrated insulin...
May 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29791766/protein-regulation-by-intrinsically-disordered-regions-a-role-for-subdomains-in-the-idr-of-the-hiv-1-rev-protein
#14
Ofrah Faust, Dana Grunhaus, Odelia Shimshon, Eylon Yavin, Assaf Friedler
Intrinsically disordered regions (IDRs) in proteins are highly abundant, but they are still commonly viewed as long stretches of polar, solvent accessible residues. Here we show that the disordered C-terminal domain of HIV-1 Rev has two sub-regions that carry out two distinct complementary roles of regulating oligomerization and contributing to stability. We propose this is carried out by a delicate balance between charged and hydrophobic residues within the IDR. We suggest that intrinsically disordered regions in proteins should be divided to sub domains similarly to structured regions, rather than being viewed as a long flexible stretches...
May 23, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29791735/practical-considerations-for-transitioning-early-childhood-interventions-to-scale-lessons-from-the-saving-brains-portfolio
#15
James M Radner, Marvin J S Ferrer, Dominique McMahon, Anuraj H Shankar, Karlee L Silver
Small pilot studies of young children have frequently shown promise, but very few have been successfully scaled to the regional or national levels. How can we ensure that these promising approaches move from a suite of pilots to full-scale implementation that can deliver sustainable impact for hundreds of millions of children? To elucidate concrete lessons learned and suggestions on accelerating the transition to impact at scale, we reviewed the Saving Brains portfolio to better understand three points: (1) the extent to which useful signals of impact could be extracted from data at the seed phase, (2) the ways in which innovators (project leaders) were approaching human resource challenges critical for scaling, and (3) the multisector diversity of the portfolio and the way innovators entered partnerships...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29791707/evaluation-of-the-safety-and-efficacy-of-a-novel-radiofrequency-device-for-vaginal-treatment
#16
Jeffrey C Caruth
INTRODUCTION: Vaginal laxity and atrophy are caused mainly by aging and vaginal childbirth, which lead to a loss of strength and flexibility within the vaginal wall. As a result, women may experience vaginal, pelvic, sexual and urinary symptoms that significantly affect their quality of life. OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of a novel radiofrequency (RF) device for internal and external vaginal treatment. METHODS: Thirty women who had been diagnosed with symptoms of vaginal laxity and pelvic relaxation received a single treatment that consisted of continuous RF in the internal genitalia and continuous RF followed by fractional RF in the external vulva...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791700/closing-the-gap-novel-abdominal-wound-closure-techniques
#17
James Dana Kondrup, Alaina M Qayyum
Traditionally, surgical procedures within the realm of both general and gynecological surgery employ the use of staples and interrupted sutures that run continuously with knot tying or subcuticular sutures to ensure closure of large wound incisions, subcuticular incisions, and fascial repair. However, these methods may not always be cosmetically favorable and, thus, result in an unpleasant outcome for the patient, adding to their surgery-related stress. It is, therefore, imperative that surgeons and gynecologists are aware of alternative methods of wound closure that are not only cosmetically favorable, but also ensure rapid wound recovery and infection control...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791507/a-novel-mouse-model-of-campylobacter-jejuni-enteropathy-and-diarrhea
#18
Natasa Giallourou, Gregory L Medlock, David T Bolick, Pedro Hqs Medeiros, Solanka E Ledwaba, Glynis L Kolling, Kenneth Tung, Patricia Guerry, Jonathan R Swann, Richard L Guerrant
Campylobacter infections are among the leading bacterial causes of diarrhea and of 'environmental enteropathy' (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29791483/structural-study-reveals-the-temperature-dependent-conformational-flexibility-of-tk-ptp-a-protein-tyrosine-phosphatase-from-thermococcus-kodakaraensis-kod1
#19
Hye-Yeoung Yun, Jinhyuk Lee, Hyunmin Kim, Hyojung Ryu, Ho-Chul Shin, Byung-Ha Oh, Bonsu Ku, Seung Jun Kim
Protein tyrosine phosphatases (PTPs) originating from eukaryotes or bacteria have been under intensive structural and biochemical investigation, whereas archaeal PTP proteins have not been investigated extensively; therefore, they are poorly understood. Here, we present the crystal structures of Tk-PTP derived from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1, in both the active and inactive forms. Tk-PTP adopts a common dual-specificity phosphatase (DUSP) fold, but it undergoes an atypical temperature-dependent conformational change in its P-loop and α4-α5 loop regions, switching between the inactive and active forms...
2018: PloS One
https://www.readbyqxmd.com/read/29791481/a-semi-nonparametric-poisson-regression-model-for-analyzing-motor-vehicle-crash-data
#20
Xin Ye, Ke Wang, Yajie Zou, Dominique Lord
This paper develops a semi-nonparametric Poisson regression model to analyze motor vehicle crash frequency data collected from rural multilane highway segments in California, US. Motor vehicle crash frequency on rural highway is a topic of interest in the area of transportation safety due to higher driving speeds and the resultant severity level. Unlike the traditional Negative Binomial (NB) model, the semi-nonparametric Poisson regression model can accommodate an unobserved heterogeneity following a highly flexible semi-nonparametric (SNP) distribution...
2018: PloS One
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