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Tiffany L Hutchins, Patricia A Prelock
Episodic memory (EM) and scene construction are critical for organizing and understanding personally experienced events and for developing several aspects of social cognition including self-concept, identity, introspection, future thinking, counterfactual reasoning, theory of mind, self-regulation, flexible problem-solving, and socially adaptive behavior. This article challenges the reader to think differently about EM in children with autism spectrum disorder (ASD), as we expand our understanding of autobiographical memory that requires an ability to travel back in time and re-experience an event...
April 2018: Seminars in Speech and Language
Karina Panczyk, Karolina Gaweda, Mateusz Drach, Wojciech Plazinski
An extension of the GROMOS 56a6CARBO/CARBO_R force field for hexopyranose-based carbohydrates is presented. The additional parameters describe the conformational properties of uronate residues. The three distinct chemical states of the carboxyl group are considered: deprotonated (negatively charged), protonated (neutral) and esterified (neutral). The parameterization procedure was based on quantum-chemical calculations and the resulting parameters were tested in the context of: (i) flexibility of the pyranose rings under different pH conditions; (ii) conformation of the glycosidic linkage of the (1→4)-type for uronates with different chemical states of carboxyl moieties; (iii) conformation of the exocyclic (i...
March 20, 2018: Journal of Physical Chemistry. B
Konstantinos Daskalakis, Aaro Ilmari Väkeväinen, Jani-Petri Martikainen, Tommi K Hakala, Päivi Törmä
Nanoscale coherent light sources offer potentially ultrafast modulation speeds which could be utilized for novel sensors and optical switches. Plasmonic periodic structures combined with organic gain materials have emerged as promising candidates for such nanolasers. Their plasmonic component provides high intensity and ultrafast nanoscale-confined electric fields, while organic gain materials offer fabrication flexibility and low acquisition cost. Despite reports on lasing in plasmonic arrays, lasing dynamics in these structures has not been experimentally studied yet...
March 20, 2018: Nano Letters
Heekyeong Park, Sungho Lee, Seok Hwan Jeong, Ui Hyun Jung, Kidong Park, Min Goo Lee, Sunkook Kim, Joonhyung Lee
Flexible sensors connected to cell phones are a promising technology that can aid in continuously monitoring signals in our daily lives, such as an individual's health status and information from buildings, farms, and industry. Among such signals, real-time humidity monitoring is crucial to a comfortable life, as human bodies, plants, and industrial environments require appropriate humidity to be maintained. We propose a hydrophilic polytetrafluoroethylene (H-PTFE)-based flexible humidity sensor integrated with readout circuitry, wireless communication, and a mobile battery...
March 20, 2018: Sensors
Maria Spies, Jakub Polaczynski, Akhil Ajay, Dipankar Kalita, Jonas Lähnemann, Bruno Gayral, Martien den Hertog, Eva Monroy
Nanowire photodetectors are investigated because of their compatibility with flexible electronics, or for the implementation of on-chip optical interconnects. Such devices are characterized by ultrahigh photocurrent gain, but their photoresponse scales sublinearly with the optical power. Here, we present a study of single-nanowire photodetectors displaying a linear response to ultraviolet illumination. Their structure consists of a GaN nanowire incorporating an AlN/GaN/AlN heterostructure, which generates an internal electric field...
March 20, 2018: Nanotechnology
Sonia González-Fernández, Concepción Fernández-Rodríguez
This study aimed to analyse published studies regarding the usefulness of Acceptance and Commitment Therapy in the treatment of oncological patients. A systematic review of the literature was conducted using the Web of Science, Google Scholar and Dialnet (2000-2016). Nineteen articles fulfilled the inclusion criteria. Those patients who received interventions based on Acceptance and Commitment Therapy showed a better emotional state and quality of life and greater psychological flexibility. Acceptance and Commitment Therapy proved to be useful in the psychological treatment of oncological patients...
March 20, 2018: Behavioral Medicine
Louise Ewing, Elizabeth Pellicano, Harriet King, Laura Lennuyeux-Comnene, Emily K Farran, Annette Karmiloff-Smith, Marie L Smith
Unusual patterns of fixation behavior in individuals with autism spectrum disorder during face tasks hint at atypical processing strategies that could contribute to diminished face expertise in this group. Here, we use the Bubbles reverse correlation technique to directly examine face-processing strategies during identity judgments in children with and without autism, and typical adults. Results support a qualitative atypicality in autistic face processing. We identify clear differences not only in the specific features relied upon for face judgments, but also more generally in the extent to which they demonstrate a flexible and adaptive profile of information use...
March 20, 2018: Developmental Neuropsychology
Salvador Martínez-Bartolomé, J Alberto Medina-Aunón, Miguel Ángel López-García, Carmen González-Tejedo, Gorka Prieto, Rosana Navajas, Emilio Salazar-Donate, Carolina Fernandez-Costa, John R Yates, Juan Pablo Albar
Mass spectrometry-based proteomics has evolved into a high-throughput technology where numerous large-scale datasets are generated from diverse analytical platforms. Furthermore, several scientific journals and funding agencies have emphasized the storage of proteomics data in public repositories to facilitate its evaluation, inspection and reanalysis. As a consequence, public proteomics data repositories are growing rapidly. However, tools are needed to integrate multiple proteomics datasets in order to compare different experimental features or to perform quality control analysis...
March 20, 2018: Journal of Proteome Research
Luciano A Favorito
No abstract text is available yet for this article.
March 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rohan Hazra, Susan Tenney, Alexandra Shlionskaya, Rajni Samavedam, Kristin Baxter, John Ilekis, Jennifer Weck, Marian Willinger, Gilman Grave, Katerina Tsilou, David Songco
The benefits of data sharing are well-established and an increasing number of policies require that data be shared upon publication of the main study findings. As data sharing becomes the new norm, there is a heightened need for additional resources to drive efficient data reuse. This article describes the development and implementation of the Data and Specimen Hub (DASH) by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to promote data sharing from NICHD-funded studies and enable researchers to comply with NIH data sharing policies...
March 20, 2018: Scientific Data
Sanjay V Desai, David A Asch, Lisa M Bellini, Krisda H Chaiyachati, Manqing Liu, Alice L Sternberg, James Tonascia, Alyssa M Yeager, Jeremy M Asch, Joel T Katz, Mathias Basner, David W Bates, Karl Y Bilimoria, David F Dinges, Orit Even-Shoshan, David M Shade, Jeffrey H Silber, Dylan S Small, Kevin G Volpp, Judy A Shea
Background Concern persists that inflexible duty-hour rules in medical residency programs may adversely affect the training of physicians. Methods We randomly assigned 63 internal medicine residency programs in the United States to be governed by standard duty-hour policies of the 2011 Accreditation Council for Graduate Medical Education (ACGME) or by more flexible policies that did not specify limits on shift length or mandatory time off between shifts. Measures of educational experience included observations of the activities of interns (first-year residents), surveys of trainees (both interns and residents) and faculty, and intern examination scores...
March 20, 2018: New England Journal of Medicine
Alexandre Khaldi, Daniel Falk, Katarina Bengtsson, Ali Maziz, Daniel Filippini, Nathaniel D Robinson, Edwin W H Jager
There is a need for soft actuators in various biomedical applications in order to manipulate delicate objects such as cells and tissues. Soft actuators are able to adapt to any shape and limit the stress applied to delicate objects. Conjugated polymer actuators, especially in the so-called trilayer configuration, are interesting candidates for driving such micromanipulators. However, challenges involved in patterning the electrodes in a trilayer with individual contact have prevented further development of soft micromanipulators based on conjugated polymer actuators...
March 20, 2018: ACS Applied Materials & Interfaces
Mimi M Li, Mohamad S Hamady, Colin D Bicknell, Celia V Riga
Flexible robotic catheters are an emerging technology which provide an elegant solution to the challenges of conventional endovascular intervention. Originally developed for interventional cardiology and electrophysiology procedures, remotely steerable robotic catheters such as the Magellan system enable greater precision and enhanced stability during target vessel navigation. These technical advantages facilitate improved treatment of disease in the arterial tree, as well as allowing execution of otherwise unfeasible procedures...
March 19, 2018: Journal of Cardiovascular Surgery
Kei-Anne Baritugo, Hee Taek Kim, Yokimiko David, Jong-Il Choi, Soon Ho Hong, Ki Jun Jeong, Jong Hyun Choi, Jeong Chan Joo, Si Jae Park
Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for L-glutamate and L-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids...
March 20, 2018: Applied Microbiology and Biotechnology
Yu Ke, Caikun Liu, Yanting Wang, Meng Xiao, Jiachen Fan, Pengcheng Fu, Shuhao Wang, Gang Wu
Cell-loaded carboxymethylcellulose (CMC) microspheres were generated via a flow focusing microfluidic device, with a final aim to obtain viable ATDC5 aggregates with sustained proliferation capacity. We synthesized various CMC with phenolic groups (CMC-Ph) and demonstrated that high CMC-Ph molecular weight, high CMC-Ph concentration (>0.8 g/ml) or long culturing period had obvious inhibition effect on ATDC5 proliferation, but low horseradish peroxidase concentration (HRP, <0.4 mg/ml) did not. CMC-Ph gels being obtained through HRP/H2 O2 reaction showed an enhancing strength and decreasing break stain as the molecular weight of CMC-Ph increased, along with a decreasing gelation time...
March 20, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Li-Chuan Jia, Ding-Xiang Yan, Xiaofeng Liu, Rujun Ma, Hong-Yuan Wu, Zhongming Li
Electromagnetic protection in optoelectronic instruments such as optical windows and electronic displays is challenging because of the essential requirements of a high optical transmittance and an electromagnetic interference (EMI) shielding effectiveness (SE). Herein, we demonstrate the creation of an efficient transparent EMI shielding film that is composed of calcium alginate (CA), silver nanowires (AgNWs), and polyurethane (PU), via a facile and low-cost Meyer-rod coating method. The CA/AgNWs/PU film with a high optical transmittance of 92% achieves an EMI SE of 20...
March 20, 2018: ACS Applied Materials & Interfaces
Caroline Lenette, Jessica R Botfield, Katherine Boydell, Bridget Haire, Christy E Newman, Anthony B Zwi
Visual research methods like photography and digital storytelling are increasingly used in health and social sciences research as participatory approaches that benefit participants, researchers, and audiences. Visual methods involve a number of additional ethical considerations such as using identifiable content and ownership of creative outputs. As such, ethics committees should use different assessment frameworks to consider research protocols with visual methods. Here, we outline the limitations of ethics committees in assessing projects with a visual focus and highlight the sparse knowledge on how researchers respond when they encounter ethical challenges in the practice of visual research...
March 19, 2018: Journal of Bioethical Inquiry
Gautam J K Tawari, Rajan Maheshwari, Sanjeev S Madan
A good long-term outcome following a total knee arthroplasty relies on restoration of the mechanical axis and effective soft tissue balancing of the prosthetic knee. Arthroplasty surgery in patients with secondary osteoarthritis of the knee with an extra-articular tibial deformity is a complex and challenging procedure. The correction of mal-alignment of the mechanical axis is associated with unpredictable result and with higher revision rates. Single-staged deformity correction and replacement surgery often result in the use of constraint implants...
March 20, 2018: Strategies in Trauma and Limb Reconstruction
Amy Goldman, Alison Metcalfe, Rhona MacLeod
When a boy is diagnosed with an X-linked condition such as Duchenne or Becker muscular dystrophy (D/BMD), the mother learns not only of her own potential carrier risk but also that of her daughters. Before the daughters are seen in the Genetics Clinic, responsibility for disclosing carrier risk information falls mainly to their mothers. We know little about if when and how these daughters are being told about their risk, and how mothers find the experience. Should we be doing more to help and support them? Using qualitative methods, six mothers known to the Manchester Centre for Genomic Medicine were interviewed about the disclosure of D/BMD carrier risk information to their daughters...
March 19, 2018: Journal of Genetic Counseling
Patricia Cristine Borck, Jean Franciesco Vettorazzi, Renato Chaves Souto Branco, Thiago Martins Batista, Junia Carolina Santos-Silva, Vanessa Yumi Nakanishi, Antonio Carlos Boschero, Rosane Aparecida Ribeiro, Everardo Magalhães Carneiro
The sulfur-containing amino acid, taurine (Tau), regulates glucose and lipid homeostasis under normal, pre- and diabetic conditions. Here, we aimed to verify whether Tau supplementation exerts its beneficial effects against obesity, hyperglycemia and alterations in islet functions, in leptin-deficient obese (ob/ob), over a long period of treatment. From weaning until 12 months of age, female ob/ob mice received, or not, 5% Tau in drinking water (obTau group). After this period, a reduction in hypertriglyceridemia and an improvement in glucose tolerance and insulin sensitivity were observed in obTau mice...
March 19, 2018: Amino Acids
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