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https://www.readbyqxmd.com/read/28724269/association-of-human-methionine-synthase-a2756g-transition-with-prostate-cancer-a-case-control-study-and-in-silico-analysis
#1
Arezou Ebrahimi, Abasalt Hosseinzadeh Colagar, Mohammad Karimian
Methionine synthase (MTR) is one of the key enzymes of folate pathway, which play a key role in the construction, repair, and methylation of DNA. In this study, an association of MTR A2756G gene transition with prostate cancer in men populations of Kashan-Iran was investigated by a case-control study and an in silico analysis. The 200 samples including 100 patients with prostate cancer, as case group and 100 healthy men, as control group included in this study. MTR-A2756G genotyping was performed by PCR-RFLP technique...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724265/facile-synthesis-of-sio2-c-nanoparticles-anchored-on-mwnt-as-high-performance-anode-materials-for-li-ion-batteries
#2
Yan Zhao, Zhengjun Liu, Yongguang Zhang, Almagul Mentbayeva, Xin Wang, M Yu Maximov, Baoxi Liu, Zhumabay Bakenov, Fuxing Yin
Carbon-coated silica nanoparticles anchored on multi-walled carbon nanotubes (SiO2@C/MWNT composite) were synthesized via a simple and facile sol-gel method followed by heat treatment. Scanning and transmission electron microscopy (SEM and TEM) studies confirmed densely anchoring the carbon-coated SiO2 nanoparticles onto a flexible MWNT conductive network, which facilitated fast electron and lithium-ion transport and improved structural stability of the composite. As prepared, ternary composite anode showed superior cyclability and rate capability compared to a carbon-coated silica counterpart without MWNT (SiO2@C)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28724142/the-aging-physician-and-the-medical-profession-a-review
#3
E Patchen Dellinger, Carlos A Pellegrini, Thomas H Gallagher
Importance: The issue of the aging physician and when to cease practice has been controversial for many years. There are reports of prominent physicians who practiced after becoming dangerous in old age, but the profession has not demonstrated the ability to prevent this. A mandatory retirement age could be discriminatory and take many competent physicians out of practice and risk a physician shortage. An increasing body of evidence regarding the relationship between physicians' age and performance has led organizations, such as the American College of Surgeons, to revisit this challenge...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724089/grower-analysis-of-organic-matter-amendments-in-california-orchards
#4
Sat Darshan S Khalsa, Patrick H Brown
Organic matter amendments supply crop nutrients and enhance soil health, yet information specific to orchards is lacking. A survey was conducted to analyze use of these materials by California almond [ (Mill.) D.A. Webb] growers. Significant differences were observed for benefits, concerns, and accessibility to manure and green waste sources and between users and nonusers. Use patterns were significantly influenced by heavy and light users, farm size, and geographic region. Enhanced soil biology was the main benefit attributed to organic matter amendments by both users and nonusers...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28723827/neurocognitive-and-symptom-trajectories-of-adhd-from-childhood-to-early-adolescence
#5
Andrea L Murray, Thomas Robinson, Gail Tripp
OBJECTIVE: This longitudinal study investigated changes in neurocognitive functioning from childhood to early adolescence in a sample of children diagnosed with DSM-IV attention-deficit hyperactivity disorder (ADHD). It also compared the neurocognitive trajectories of children who continued to meet the diagnostic criteria for ADHD at follow-up and those in partial remission. METHODS: Children diagnosed with ADHD (N = 55) were tested at baseline (M = 7.7 years, SD = 1...
July 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723679/preparation-and-application-of-n-doped-carbon-nanotube-arrays-on-graphene-fibers
#6
Mochen Li, Xiaohong Zhang, Haibin Jiang, Xiang Wang, Yue Ru, Jinliang Qiao
A new kind of carbon hybrid material with unique structure, outstanding mechanical and functional properties is reported in this article. Nitrogen-doped carbon nanotube arrays with inside located Ni particles are in-situ grown on the surface of phenolic carbon modified graphene fibers during their conversion from graphene oxide fibers. The carbon hybrid fiber exhibits not only high tensile strength and elongation at break, but also excellent flexibility since the carbon nanotube arrays cover the all surface of highly strong graphene fiber...
July 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28723584/the-relationship-between-growth-performance-and-metabolic-rate-flexibility-varies-with-food-availability-in-juvenile-qingbo-spinibarbus-sinensis
#7
Ling-Qing Zeng, Lei Wang, Guang-Nan Wang, Yue Zeng, Shi-Jian Fu
Phenotypic flexibility in traits can allow organisms to cope with environmental challenges. However, the ecological consequences (e.g., growth) of SMR flexibility in fish are poorly understood. Juvenile qingbo (Spinibarbus sinensis) were reared individually with two levels of food resources (satiation or limited) with either continuous feeding (CF) or starvation-refeeding (SR). In the CF experiment, SMR increased when individuals were fed either the satiation or limited diets, but no difference was found in average specific growth rate somatic growth (SGR) between the two food availabilities...
July 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28723308/percutaneous-trans-tracheal-endoscopic-approach-a-novel-technique-for-the-excision-of-benign-lesions-of-thoracic-trachea
#8
Suresh C Sharma, K Devaraja, Arvind Kairo, Rakesh Kumar
INTRODUCTION: Currently, neoplasms of the trachea and lower airway demand open transcervical approach with or without thoracotomy. We describe here a novel, minimally invasive approach for an intraluminal lesion of the thoracic trachea, called percutaneous trans-tracheal endoscopic approach (PTEA). Apart from obvious advantages over potentially morbid open procedures, this technique has certain peculiar benefits over rigid or flexible bronchoscopic approach. MATERIALS AND METHODS: A 43-year-old male patient had glomus tumor of thoracic trachea...
July 19, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28723234/flexible-small-molecular-anti-estrogens-with-n-n-dialkylated-2-5-diethoxy-4-morpholinoaniline-scaffold-targets-multiple-estrogen-receptor-conformations
#9
Bethany K Asare, Emmanuel Yawson, Rajendram V Rajnarayanan
Estrogen mediates various cellular processes including cell proliferation, differentiation, growth and mammary gland function. Estrogen Receptors (ERs) are expressed in 70% of breast cancers. Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. However, in the absence of a cognate estrogenic ligand, ERs can be activated by a variety of other extracellular signals. Tamoxifen, an anti-estrogen that selectively targets ER, induces substantial regression of breast tumors and an increase in disease-free survival...
July 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28723230/retrograde-endourological-management-of-upper-urinary-tract-abnormalities-in-patients-with-ileal-conduit-urinary-diversion-a-dual-center-experience
#10
Louise Olson, Hywel Satherley, Paul Cleaveland, Bachar Zelhof, Max Mokete, Donald Neilson, Shalom Srirangam
INTRODUCTION: Patients with ileal conduit urinary diversions are at an increased risk of long-term upper urinary tract (UUT) complications, including anastomotic strictures, infections, and urolithiasis. The reconstructed urinary system poses challenges for endoscopic manipulation. We present and describe our dual-center experience in performing retrograde ureteroscopy to treat or diagnose UUT abnormalities in patients with ileal conduit incontinent diversion. PATIENT AND METHODS: We performed a retrospective analysis of medical records for all patients with previous urinary diversion who underwent retrograde ureteroscopic procedures via the ileal loop in our institutions over a 9 year period (between June 2007 and August 2016)...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28723224/high-throughput-automated-preparation-and-simulation-of-membrane-proteins-with-htmd
#11
Stefan Doerr, Toni Giorgino, Gerard Martinez-Rosell, João M Damas, Gianni De Fabritiis
HTMD is a programmable scientific platform intended to facilitate simulation-based research in molecular systems. This paper presents the functionalities of HTMD for the preparation of a molecular dynamics simulation starting from PDB structures, building the system using well-known forcefields and applying standardized protocols for running the simulations. We demonstrate the framework's flexibility for high-throughput molecular simulations by applying a preparation, building and simulation protocol with multiple force-fields on all of the seven hundred eukaryotic membrane proteins resolved to-date from the orientation of proteins in membranes (OPM) database...
July 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28723207/wearable-flexible-and-multifunctional-healthcare-device-with-an-isfet-chemical-sensor-for-simultaneous-sweat-ph-and-skin-temperature-monitoring
#12
Shogo Nakata, Takayuki Arie, Seiji Akita, Kuniharu Takei
Real-time daily healthcare monitoring may increase the chances of predicting and diagnosing diseases in their early stages which, currently, occurs most frequently during medical check-ups. Next-generation noninvasive healthcare devices, such as flexible multifunctional sensor sheets designed to be worn on skin, are considered to be highly suitable candidates for continuous real-time health monitoring. For healthcare applications, acquiring data on the chemical state of the body, alongside physical characteristics such as body temperature and activity, are extremely important for predicting and identifying potential health conditions...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723200/flexible-transparent-and-free-standing-silicon-nanowire-sers-platform-for-in-situ-food-inspection
#13
Hao Cui, Shuoyu Li, Shaozhi Deng, Huanjun Chen, Chengxin Wang
We demonstrated a flexible transparent and free-standing Si nanowire paper (SiNWP) as a surface enhanced Raman scattering (SERS) platform for in situ chemical sensing on warping surfaces with high sensitivity. The SERS activity has originated from the three-dimension interconnected nanowire network structure and electromagnetic coupling between closely separated nanowires in the SiNWP. In addition, the SERS activity can be highly improved by functionalizing the SiNWP with plasmonic Au nanoparticles. The hybrid substrate not only showed excellent reproducibility and stability of the SERS signal, but also maintained the flexibility and transparency of the pristine SiNWP...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723187/wearable-flexible-and-stretchable-glove-biosensor-for-on-site-detection-of-organophosphorus-chemical-threats
#14
Rupesh K Mishra, Lee J Hubble, Aida Martín, Rajan Kumar, Abbas Barfidokht, Jayoung Kim, Mustafa M Musameh, Ilias L Kyratzis, Joseph Wang
A flexible glove-based electrochemical biosensor with highly stretchable printed electrode system has been developed as a wearable point-of-use screening tool for defense and food security applications. This disposable-mechanically robust "lab-on-a-glove" integrates a stretchable printable enzyme-based biosensing system and active surface for swipe sampling on different fingers, and is coupled with a compact electronic interface for electrochemical detection and real-time wireless data transmission to a smartphone device...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723173/laser-scribed-graphene-electrodes-for-aptamer-based-biosensing
#15
Christoph Fenzl, Pranati Nayak, Thomas Hirsch, Otto S Wolfbeis, Husam N Alshareef, Antje J Baeumner
Graphene as a transducer material has produced some of the best-performing sensing approaches to date opening the door toward integrated miniaturized all-carbon point-of-care devices. Addressing this opportunity, laser-scribed graphene (LSG) electrodes are demonstrated here as highly sensitive and reliable biosensor transducers in blood serum analysis. These flexible electrodes with large electrochemical surface areas were fabricated using a direct-write laser process on polyimide foils. A universal immobilization approach is established by anchoring 1-pyrenebutyric acid to the graphene and subsequently covalently attaching an aptamer against the coagulation factor thrombin as an exemplary bioreceptor to the carboxyl groups...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723119/fast-response-and-flexible-nanocrystal-based-humidity-sensor-for-monitoring-human-respiration-and-water-evaporation-on-skin
#16
Shinya Kano, Kwangsoo Kim, Minoru Fujii
We develop a fast-response and flexible nanocrystal-based humidity sensor for real-time monitoring of human activity: respiration and water evaporation on skin. A silicon-nanocrystal film is formed on a polyimide film by spin-coating the colloidal solution and is used as a flexible and humidity-sensitive material in a humidity sensor. The flexible nanocrystal-based humidity sensor shows a high sensitivity; current through the nanocrystal film changes by 5 orders of magnitude in the relative humidity range of 8-83%...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723090/transformative-heterointerface-evolution-and-plasmonic-tuning-of-anisotropic-trimetallic-nanoparticles
#17
Mouhong Lin, Gyeong-Hwan Kim, Jae-Ho Kim, Jeong-Wook Oh, Jwa-Min Nam
Multi-component nanoparticles that incorporate multiple nano-crystal domains into a single particle represent an important class of material with highly tailorable structures and properties. The controlled synthesis of multi-component NPs with 3 or more components with the desired structure, particularly aniso-tropic structures, and property is, however, highly challenging. Here, we developed a polymer and galvanic replacement reac-tion-based transformative heterointerface evolution (THE) method to form and tune gold-copper-silver multi-metallic ani-sotropic nanoparticles (MAPs) with well-defined configurations, including structural order, uniformity and junction geometry, giving rise to extraordinarily high tunability in the structural design, synthesis and optical property of tri-metallic plasmonic nanoantenna structures...
July 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28723074/paper-based-bimodal-sensor-for-electronic-skin-applications
#18
Minhyun Jung, Kyungkwan Kim, Bumjin Kim, Haena Cheong, Kwanwoo Shin, Oh-Sun Kwon, Jong-Jin Park, Sanghun Jeon
We present the development of a flexible bimodal sensor using a paper platform and ink-jet printing method, which are suited for low-cost fabrication processes and realization of flexible devices. In this study, we employed a vertically stacked bimodal device architecture in which a temperature sensor is stacked on top of a pressure sensor and operated on different principles, allowing the minimization of interference effects. For the temperature sensor placed in the top layer, we used the thermoelectric effect and formed a closed-loop thermocouple composed of two different printable inks: conductive PEDOT:PSS and silver nanoparticles on a flexible paper platform, and obtained temperature-sensing capability over a wide range (150 ℃)...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28723068/biomimetic-hybridization-of-kevlar-into-silk-fibroin-nanofibrous-strategy-for-improved-mechanic-properties-of-flexible-composites-and-filtration-membranes
#19
Lili Lv, Xiangsheng Han, Lu Zong, Mingjie Li, Jun You, Xiaochen Wu, Chaoxu Li
Silk, one of the strongest natural biopolymers, was hybridized with Kevlar, one of the strongest synthetic polymers, through a biomimetic nanofibrous strategy. Regenerated silk materials have outstanding properties in transparency, biocompatibility, biodegradability and sustainability, and promised the applications as diverse as in pharmaceutics, electronics, photonic devices and membranes. To compete with super mechanic properties of their natural counterpart, regenerated silk materials have been hybridized with inorganic fillers such as graphene and carbon nanotubes, but frequently losing essential mechanic flexibility...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28722784/the-universal-collaborative-dynamic-model-of-specialist-and-advanced-nursing-and-midwifery-practice-a-way-forward
#20
Laserina O'Connor, Mary Casey, Rita Smith, Gerard Michael Fealy, Denise O' Brien, Denise O'Leary, Diarmuid Stokes, Martin S McNamara, Mary Ellen Glasgow, Andrew Cashin
BACKGROUND: There is a sizable body of empirical literature supporting the unique contributions of specialist and advanced practice roles to health care. However, there is very little international evidence to inform the integration of a future model for advanced or specialist practice in the Irish health care system. AIM: The aim of this study was to inform and guide the development of a future model of specialist and advanced nursing and midwifery practice. DESIGN: A qualitative study was conducted to initiate this important area of inquiry...
July 19, 2017: Journal of Clinical Nursing
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