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Xing-Hai Liu, Wen Zhao, Zhong-Hua Shen, Jia-Hua Xing, Tian-Ming Xu, Wei-Li Peng
A series of novel difluoromethylpyrazole carboxamides derivatives were synthesized by introduction of flexible alkyl chain. Nematicidal bioassay results showed that some of them exhibited good control efficacy against M. incognita, which indicated that these difluoromethylpyrazole carboxamides derivatives might be potential novel lead compounds for discovery new nematicides. The nematicidal activity was affected by the substituted position in the molecule, especially the substitution group on the alkyl chain...
October 10, 2016: European Journal of Medicinal Chemistry
Chencheng Sun, Bowen Xiong, Yang Pan, Hao Cui
Polyaniline (PANI) prepared by chemical oxidation was studied for adsorption removal of tannic acid (TA) from aqueous solution. Batch adsorption studies were carried out under different adsorbent dosages, pH, ionic strength, initial TA concentration and coexisting anions. Solution pH had an important impact on TA adsorption onto PANI with optimal removal in the pH range of 8-11. TA adsorption on PANI at three ionic strength levels (0.02, 0.2 and 2molL(-1) NaCl) could be well described by Langmuir model (monolayer adsorption process) and the maximum adsorption capacity was 230, 223 and 1023mgg(-1), respectively...
October 15, 2016: Journal of Colloid and Interface Science
Isabel P G Fernandes, Ana Maria Oliveira-Brett
Calmodulin (CaM) is an essential protein present in all eukaryote cells, ranging from vertebrates to unicellular organisms. CaM is the most important Ca(2+) signalling protein, composed of two domains, N- and C-terminal domains, linked by a flexible central α-helix, and is responsible for the regulation of numerous calcium-mediated signalling pathways. Four calcium ions bind to CaM, changing its conformation and determining how it recognizes and regulates its cellular targets. The oxidation mechanism of native and denatured CaM, at a glassy carbon electrode, was investigated using differential pulse voltammetry and electrochemical impedance spectroscopy...
October 7, 2016: Bioelectrochemistry
Sinéad Kinsella, Jochen H M Prehn
In this issue of Molecular Cell, Fu et al. (2016) present a detailed structural analysis of death-inducing signaling complex (DISC) assembly and regulation through flexible caspase-8 interactions with cFLIPL, cFLIPS, and the viral inhibitor MC159, thereby identifying novel apoptosis control mechanisms.
October 20, 2016: Molecular Cell
Richard A Manderville, Stacey D Wetmore
The formation of DNA adducts by the attack of intermediates derived from toxic substances at the C8 position of 2-deoxyguanosine (dG) is a common damaging event. Although the majority of studies on C8-dG adducts have focused on lesions containing a C8-N-C tether between the bulky moiety and the nucleobase, the formation of O-linked lesions with a similar tether topology and C-linked adducts involving direct C8-C connectivity have also been uncovered. Several studies have been done to try to better understand the structural impact and mutagenicity of O-linked and C-linked aryl C8-dG adducts, including lesions arising from unsubstituted and chloro substituted phenols, and the food mutagen ochratoxin A (OTA)...
October 21, 2016: Chemical Research in Toxicology
A Didier, R Dietrich, E Märtlbauer
The non-hemolytic enterotoxin complex (Nhe) is supposed to be the main virulence factor of B. cereus causing a diarrheal outcome of food poisoning. This tripartite toxin consists of the single components NheA, -B and -C all of them being necessary for maximum toxicity. In the past, research activities aiming to elucidate the mode-of-action of Nhe were mostly focused on the B- and C-component. In this study the generation of novel monoclonal antibodies (mAb) and their thorough characterization enabled the determination of key features for NheA...
2016: PloS One
Stephen Matthew Quinnan
Obtaining optimal results in the treatment of extraarticular distal tibia fractures can be challenging. Plate and screw and intramedullary fixation have proven to be effective treatments, but are associated with significant complication rates when used for open fractures and patient with severe medical comorbidities. External fixation is a third alternative that is less often employed, but provides a very effective means of treatment. Circular external fixation offers great flexibility in obtaining anatomic alignment and stable fixation for even the most challenging distal tibia fractures...
November 2016: Journal of Orthopaedic Trauma
Russell J Brooke, Mirjam Ee Kretzschmar, Volker Hackert, Christian Jpa Hoebe, Peter Fm Teunis, Lance A Waller
We develop a novel approach to study an outbreak of Q fever in 2009 in the Netherlands by combining a human dose-response model with geostatistics prediction to relate probability of infection and associated probability of illness to an effective dose of Coxiella burnetii. The spatial distribution of the 220 notified cases in the at-risk population are translated into a smooth spatial field of dose. Based on these symptomatic cases, the dose-response model predicts a median of 611 asymptomatic infections (95% range 410 to 1,084) for the 220 reported symptomatic cases in the at-risk population; 2...
October 19, 2016: Epidemiology
Ivan Vrbik, Goran Sporiš, Lovro Štefan, Dejan Madić, Nebojša Trajković, Irena Valantine, Zoran Milanović
PURPOSE: The number of familiarization sessions in fitness assessments seems to be critical and inconsistent. Therefore, the primary aim of this research was to determine the number of familiarization attempts that stabilize the results in particular physical fitness tests. The secondary aim was to establish the test reliability through familiarization sessions. METHODS: Thirty-nine primary school children participated in this research (age: 10.8 years, body mass: 40...
October 21, 2016: Pediatric Exercise Science
Eunjoo Kim, Amy Garrett, Spencer Boucher, Min-Hyeon Park, Meghan Howe, Erica Sanders, Ryan G Kelley, Allan L Reiss, Kiki D Chang, Manpreet K Singh
BACKGROUND: Prior studies have suggested that inhibited temperament may be associated with an increased risk for developing anxiety or mood disorder, including bipolar disorder. However, the neurobiological basis for this increased risk is unknown. The aim of this study was to examine temperament in symptomatic and asymptomatic child offspring of parents with bipolar disorder (OBD) and to investigate whether inhibited temperament is associated with aberrant hippocampal volumes compared with healthy control (HC) youth...
October 21, 2016: Journal of Child and Adolescent Psychopharmacology
Jing Wei, Xiuling Jiao, Ting Wang, Dairong Chen
Ink-free rewritable media has attracted great attention as a potential alternative to current paper prints, owing to its benefits to reducing paper production and consumption for environmental protection. It is desirable to develop rewritable media based on cheap, robust, and fast-response photochromic systems. Herein, we report the design and fabrication of flexible and photorewritable PVP/a-WO3 hybrid membranes through electrospinning, on which images with high resolution can be photoprinted and heat-erased for over 40 cycles...
October 21, 2016: ACS Applied Materials & Interfaces
Norihiro Mizoshita, Hiromitsu Tanaka
Antireflection (AR) coating for transparent plastic substrates is constructed by partially embedding mesoporous silica nanoparticles (MSNs) onto the surface of the substrates. Simulation of optical properties of polymer substrates coated with a single-particle MSN layer indicates that the surface has a low and graded refractive index in the direction of the thickness and effectively decreases the reflectance of visible light. The MSN-coated surfaces can be prepared by exposure of the MSN-painted substrates to a solvent vapor, irrespective of the shape of the polymer substrates...
October 21, 2016: ACS Applied Materials & Interfaces
Yazan M Dweiri, Matthew A Stone, Dustin J Tyler, Grant A McCallum, Dominique M Durand
Many attempts have been made to manufacture multi-contact nerve cuff electrodes that are safe, robust and reliable for long term neuroprosthetic applications. This protocol describes a fabrication technique of a modified cylindrical nerve cuff electrode to meet these criteria. Minimum computer-aided design and manufacturing (CAD and CAM) skills are necessary to consistently produce cuffs with high precision (contact placement 0.51 ± 0.04 mm) and various cuff sizes. The precision in spatially distributing the contacts and the ability to retain a predefined geometry accomplished with this design are two criteria essential to optimize the cuff's interface for selective recording and stimulation...
October 4, 2016: Journal of Visualized Experiments: JoVE
Szu-I Yeh, Wei-Feng Fang, Chao-Jyun Huang, Tzu-Ming Wang, Jing-Tang Yang
A simple and visual method to detect multi-nucleotide polymorphism (MNP) was performed on a pneumatic droplet manipulation platform on an open surface. This approach to colorimetric DNA detection was based on the hybridization-mediated growth of gold nanoparticle probes (AuNP probes). The growth size and configuration of the AuNP are dominated by the number of DNA samples hybridized with the probes. Based on the specific size- and shape-dependent optical properties of the nanoparticles, the number of mismatches in a sample DNA fragment to the probes is able to be discriminated...
September 27, 2016: Journal of Visualized Experiments: JoVE
Brun Jean-Frédéric, Varlet-Marie Emmanuelle, Fédou Christine, Raynaud de Mauverger Eric
Equations of blood viscosity provide a prediction of the 'optimal' hematocrit' (hct) as the hct resulting in the highest value of the bell-shaped curve of hematocrit/viscosity ratio h/η. We investigated if overweight and obesity have an influence on these parameters. We compared 32 normal weight subjects, 40 overweight (BMI 25-30) and 38 obese subjects. There was no difference in the theoretical curve of h/η. The actual h/η is the same in the 3 groups but is always higher than the theoretical h/η in all groups...
October 15, 2016: Clinical Hemorheology and Microcirculation
Xiaoming Huang, Jiadong Zhu, Tamás I Korányi, Michael D Boot, Emiel J M Hensen
Adding value to lignin, the most complex and recalcitrant fraction in lignocellulosic biomass, is highly relevant to costefficient operation of biorefineries. We report the use of homogeneous metal triflates to rapidly release lignin from biomass. Combined with metal-catalyzed hydrogenolysis, the process separates woody biomass into few lignin-derived alkylmethoxyphenols and cellulose under mild conditions. Model compound studies show the unique catalytic properties of metal triflates in cleaving lignin-carbohydrate interlinkages...
October 21, 2016: ChemSusChem
Michael G Sommer, Yvonne Rechkemmer, Lisa Suntrup, Stephan Hohloch, Margarethe van der Meer, Joris van Slageren, Biprajit Sarkar
The azido ligand is widely used in coordination chemistry both as a ligand and as a metal-bound reactant. Its role as a bridge for magnetic exchange coupling has attracted a lot of attention in polynuclear metal complexes. However, only a very limited number of complexes are known in which a single azide anion, particularly in the μ1,1-mode, is the only unsupported connection between two metal centers. We present here a series of copper(ii)-azido complexes with amine anchored, triazole-based tripodal ligands containing varying substituents...
October 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Christophe Beclin, Philipp Follert, Elke Stappers, Serena Barral, Coré Nathalie, Antoine de Chevigny, Virginie Magnone, Kévin Lebrigand, Ute Bissels, Danny Huylebroeck, Andreas Bosio, Pascal Barbry, Eve Seuntjens, Harold Cremer
During neurogenesis, generation, migration and integration of the correct numbers of each neuron sub-type depends on complex molecular interactions in space and time. MicroRNAs represent a key control level allowing the flexibility and stability needed for this process. Insight into the role of this regulatory pathway in the brain is still limited. We performed a sequential experimental approach using postnatal olfactory bulb neurogenesis in mice, starting from global expression analyses to the investigation of functional interactions between defined microRNAs and their targets...
October 21, 2016: Scientific Reports
Sinziana Mirela Popescu, Anders J Barlow, Sami Ramadan, Srinivas Ganti, Biswajit Ghosh, John Hedley
We report the first investigation into the potential of electroless nickel deposition to form ohmic contacts on single layer graphene. Aiming to minimize the contact resistance on graphene, a statistical model was used to optimize metal purity, surface roughness and coverage of the deposited film by controlling the nickel bath parameters (pH and temperature). The metalized graphene layers were patterned using photolithography and contacts deposited at temperatures as low as 60°C. The contact resistance was 215 ± 23 Ω over a contact area of 200 μm x 200 μm, which improved upon rapid annealing to 107 ± 9 Ω...
October 21, 2016: ACS Applied Materials & Interfaces
O Laporta-Hoyos, J Ballester-Plané, P Póo, A Macaya, M Meléndez-Plumed, E Vázquez, I Delgado, L Zubiaurre-Elorza, V L Botellero, A Narberhaus, E Toro-Tamargo, D Segarra, R Pueyo
PURPOSE: Quality of life (QOL) is a key outcome for people with cerebral palsy (CP), and executive functioning is an important predictor of QOL in other health-related conditions. Little is known about this association in CP or about its neural substrate. We aim to analyze the influence of executive functioning (including cognitive flexibility) as well as that of other psychological, motor, communication and socioeconomic variables on QOL and to identify neuroanatomical areas related to QOL in adolescents and adults with CP...
October 20, 2016: Quality of Life Research
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