keyword
https://read.qxmd.com/read/38294489/addendum-resolvins-suppress-tumor-growth-and-enhance-cancer-therapy
#21
JOURNAL ARTICLE
Megan L Sulciner, Charles N Serhan, Molly M Gilligan, Dayna K Mudge, Jaimie Chang, Allison Gartung, Kristen A Lehner, Diane R Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P Sukhatme, Arja Kaipainen, Mark W Kieran, Sui Huang, Dipak Panigrahy
No abstract text is available yet for this article.
March 4, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38289998/resolvin-d1-as-a-novel-target-in-the-management-of-hypertension
#22
JOURNAL ARTICLE
Xintong Zheng, Yanna Lei, Xian Wu Cheng
No abstract text is available yet for this article.
March 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/38280539/lipid-mediators-in-glaucoma-unraveling-their-diverse-roles-and-untapped-therapeutic-potential
#23
REVIEW
D J Mathew, J M Sivak
Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage and visual field loss and remains a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is a critical risk factor that requires effective management. Emerging research underscores dual roles of bioactive lipid mediators in both IOP regulation and the modulation of neurodegeneration/neuroinflammation in glaucoma. Bioactive lipids, encompassing eicosanoids, specialized pro-resolving mediators (SPMs), sphingolipids, and endocannabinoids, have emerged as crucial players in these processes, orchestrating inflammation and diverse effects on aqueous humor dynamics and tissue remodeling...
January 25, 2024: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/38264427/chemokine%C3%A2-like-receptor-1%C3%A2-positive-cells-are-present-in-the-odontoblast-layer-in-tooth-tissue-in-rats-and-humans
#24
JOURNAL ARTICLE
Daisuke Yokokawa, Naoki Umemura, Yuka Miyamoto, Nobuo Kondoh, Satoshi Kawano
Cluster of differentiation (CD)44 is a marker of dental pulp stem cells and is involved in odontoblast differentiation and calcification. Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) is also expressed in odontoblasts and dental pulp stem cells and is involved in inflammation suppression and tooth regeneration. Resolvin E1, a bioactive lipid, is a CMKLR1 ligand that mediates the chemerin-CMKLR1 interaction and suppresses pulpal inflammation. The present study clarified the intracellular and tissue localization of CD44 and CMKLR1 by immunohistochemical staining of normal pulp and pulp with pulpitis from 12-week-old male Wistar rat teeth or human teeth...
February 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38252817/specialized-proresolving-mediator-resolvin-e1-corrects-the-altered-cystic-fibrosis-nasal-epithelium-cilia-beating-dynamics
#25
JOURNAL ARTICLE
Maëlle Briottet, Khadeeja Sy, Charlie London, Abdel Aissat, Mickael Shum, Virginie Escabasse, Bruno Louis, Valérie Urbach
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation. However, cilia beating features in a CF altered environment, consisting of dehydrated airway surface liquid layer and abnormal mucus, have not been fully characterized. Furthermore, acute inflammation is normally followed by an active resolution phase requiring specialized proresolving lipid mediators (SPMs) and allowing return to homeostasis. However, altered SPMs biosynthesis has been reported in CF. Here, we explored cilia beating dynamics in CF airways primary cultures and its response to the SPMs, resolvin E1 (RvE1) and lipoxin B4 (LXB4)...
January 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38237770/rvd1-improves-resident-alveolar-macrophage-self-renewal-via-the-alx-mapk14-s100a8-a9-pathway-in-acute-respiratory-distress-syndrome
#26
JOURNAL ARTICLE
Yang Ye, Qian Yang, Jinling Wei, Chenxi Shen, Haixing Wang, Rong Zhuang, Yuan Cao, Yajun Ding, Haoran Xu, Shuyang Xiang, Hongxia Mei, Zhongwang Li, Xiya Ren, Chen Zhang, Ji Xiao, Shengxing Zheng, Ting Li, Ruifeng Zeng, Huacheng Liu, Han Lin, Wangning Shang-Guan, Ming Li, Shengwei Jin, Qian Wang
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is a pulmonary inflammatory process primarily caused by sepsis. The resolution of inflammation is an active process involving the endogenous biosynthesis of specialized pro-resolving mediators, including resolvin D1 (RvD1). Resident alveolar macrophages (RAMs) maintain pulmonary homeostasis and play a key role in the resolution phase. However, the role of RAMs in promoting the resolution of inflammation by RvD1 is unclear. OBJECTIVES: Here, we investigated the mechanisms of RvD1 on regulating RAMs to promote the resolution of ARDS...
January 16, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38232664/lipid-mediators-obtained-from-docosahexaenoic-acid-by-soybean-lipoxygenase-attenuate-rankl-induced-osteoclast-differentiation-and-rheumatoid-arthritis
#27
JOURNAL ARTICLE
Yan Su, Yunjon Han, Hack Sun Choi, Gil-Yong Lee, Hee Won Cho, Heonsik Choi, Jong Hyun Choi, Yong-Suk Jang, Jeong-Woo Seo
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by persistent inflammation and joint destruction. A lipid mediator (LM, namely, 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX in a ratio of 3:47:50) produced by soybean lipoxygenase from DHA, exhibits anti-inflammatory activity. In this study, we determined the effect of LM on collagen antibody-induced arthritis (CAIA) in mice and receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation in RAW264...
February 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38201304/simulated-microgravity-affects-pro-resolving-properties-of-primary-human-monocytes
#28
JOURNAL ARTICLE
Alessandro Leuti, Marina Fava, Niccolò Pellegrini, Giulia Forte, Federico Fanti, Francesco Della Valle, Noemi De Dominicis, Manuel Sergi, Mauro Maccarrone
Space-related stressors such as microgravity are associated with cellular and molecular alterations of the immune and inflammatory homeostasis that have been linked to the disorders that astronauts suffer from during their missions. Most of the research of the past 30 years has consistently established that innate adaptive immune cells represent a target of microgravity, which leads to their defective or dysfunctional activation, as well as to an altered ability to produce soluble mediators-e.g., cytokines/chemokines and bioactive lipids-that altogether control tissue homeostasis...
January 3, 2024: Cells
https://read.qxmd.com/read/38178174/chemr23-signaling-ameliorates-brain-injury-via-inhibiting-nlrp3-inflammasome-mediated-neuronal-pyroptosis-in-ischemic-stroke
#29
JOURNAL ARTICLE
Lan Liu, Jiawei Zhang, Kaili Lu, Yaxuan Zhang, Xiaofeng Xu, Jiangshan Deng, Xiaojie Zhang, Haibing Zhang, Yuwu Zhao, Xiuzhe Wang
BACKGROUND: Inflammatory response has been recognized as a pivotal pathophysiological process during cerebral ischemia. ChemR23 signaling is involved in the pathophysiology of various inflammatory diseases. Nevertheless, the role of ChemR23 signaling in ischemic stroke remains largely unknown. METHODS: Permanent ischemic stroke mouse model was accomplished by middle cerebral artery occlusion (MCAO). Resolvin E1 (RvE1) or chemerin-9 (C-9), the agonists of ChemR23, were administered by intracerebroventricular (i...
January 4, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38176897/atp-citrate-lyase-acly-dependent-immunometabolism-in-mucosal-t-cells-drives-experimental-colitis-in-vivo
#30
JOURNAL ARTICLE
Anja Schulz-Kuhnt, Katharina Rühle, Asal Javidmehr, Michael Döbrönti, Jana Biwank, Selina Knittel, Peter Neidlinger, Jannik Leupold, Li-Juan Liu, Mark Dedden, Regina Verena Taudte, Arne Gessner, Martin F Fromm, Dirk Mielenz, Lucas Kreiss, Maximilian J Waldner, Sebastian Schürmann, Oliver Friedrich, Barbara Dietel, Rocío López-Posadas, Christina Plattner, Sebastian Zundler, Christoph Becker, Raja Atreya, Markus F Neurath, Imke Atreya
OBJECTIVE: Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD. DESIGN: ACLY expression and its immunometabolic impact on colitogenic T cell function were analysed in mucosal T cells from patients with IBD and in two experimental colitis models...
January 4, 2024: Gut
https://read.qxmd.com/read/38169741/lung-cancer-progression-alters-lung-and-gut-microbiomes-and-lipid-metabolism
#31
JOURNAL ARTICLE
Mao Hagihara, Hideo Kato, Makoto Yamashita, Yuichi Shibata, Takumi Umemura, Takeshi Mori, Jun Hirai, Nobuhiro Asai, Nobuaki Mori, Hiroshige Mikamo
Despite advances in medical technology, lung cancer still has one of the highest mortality rates among all malignancies. Therefore, efforts must be made to understand the precise mechanisms underlying lung cancer development. In this study, we conducted lung and gut microbiome analyses and a comprehensive lipid metabolome analysis of host tissues to assess their correlation. Alternations in the lung microbiome due to lung cancer, such as a significantly decreased abundance of Firmicutes and Deferribacterota , were observed compared to a mock group...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38150385/subcutaneous-anti-inflammatory-therapies-to-prevent-burn-progression-in%C3%A2-a-swine-model-of%C3%A2-contact-burn-injury
#32
JOURNAL ARTICLE
Marc A Thompson, Lucy Shaffer, David A Larson, Michelle Stavena-Holik, Carole Nail, Logan Leatherman, Seth Tomblyn, Luke Burnett, Julie Rizzo, Robert J Christy, Christine J Kowalczewski
INTRODUCTION: If left untreated, burn injuries can deepen or progress in depth within the first 72 hours after injury as a result of increased wound inflammation, subsequently worsening healing outcomes. This can be especially detrimental to warfighters who are constrained to resource-limited environments with delayed evacuation times to higher roles of care and more effective treatment. Preventing this burn progression at the point of injury has the potential to improve healing outcomes but requires a field-deployable therapy and delivery system...
December 27, 2023: Military Medicine
https://read.qxmd.com/read/38124765/serum-resolvin-d1-potentially-predicts-neurofunctional-recovery-the-risk-of-recurrence-and-death-in-patients-with-acute-ischemic-stroke
#33
JOURNAL ARTICLE
Enzhuo Chen, Dong Zhou, Ruoyu Deng
Resolvin D1 (RvD1) represses inflammation, oxidative damage and neural injury related to acute ischemic stroke (AIS) progression. The present study aimed to explore the association of serum RvD1 with disease features, neurological recovery and prognosis in patients with AIS. A total of 212 patients with newly diagnosed AIS, whose serum RvD1 was quantified at admission and at discharge using an ELISA were enrolled in the current study. The modified Rankin scale (mRS) score was noted at 3 months after patient enrolment (M3), and patients were followed up for a median duration of 11...
January 2024: Biomedical Reports
https://read.qxmd.com/read/38117781/modulating-the-seh-eets-axis-restrains-specialized-proresolving-mediator-impairment-and-regulates-t-cell-imbalance-in-experimental-periodontitis
#34
JOURNAL ARTICLE
Henrique B Abdalla, Luciano Puhl, Carla Alvarez Rivas, Yu-Chiao Wu, Paola Rojas, Carlos Antonio Trindade-da-Silva, Bruce D Hammock, Krishna R Maddipati, Mariana Q S Soares, Juliana T Clemente-Napimoga, Alpdogan Kantarci, Marcelo H Napimoga, Thomas E Van Dyke
Epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids are short-acting lipids involved in resolution of inflammation. Their short half-life, due to its metabolism by soluble epoxide hydrolase (sEH), limits their effects. Specialized proresolving mediators (SPMs) are endogenous regulatory lipids insufficiently synthesized in uncontrolled and chronic inflammation. Using an experimental periodontitis model, we pharmacologically inhibited sEH, examining its impact on T cell activation and systemic SPM production...
December 20, 2023: Journal of Immunology
https://read.qxmd.com/read/38093843/metabolization-of-resolvin-e4-by-%C3%AF-oxidation-in-human-neutrophils-synthesis-and-biological-evaluation-of-20-hydroxy-resolvin-e4-20-oh-rve4
#35
JOURNAL ARTICLE
Amalie Føreid Reinertsen, Stephania Libreros, Robert Nshimiyimana, Charles Nicholas Serhan, Trond Vidar Hansen
Resolvin E4 (RvE4) belongs to the resolvin family of specialized pro-resolving mediators (SPMs). The resolvins are endogenously formed mediators with both potent pro-resolving and anti-inflammatory biological activities and have attracted considerable attention in both inflammation research and drug discovery. Hence, further metabolism of the resolvins is of interest. Gaining knowledge about the structure-function of further metabolites of the resolvins is important due to their interest in drug-discovery efforts...
December 8, 2023: ACS Pharmacology & Translational Science
https://read.qxmd.com/read/38091977/an-inflammation-resolution-promoting-intervention-prevents-atrial-fibrillation-due-to-left-ventricular-dysfunction
#36
JOURNAL ARTICLE
Roddy Hiram, Feng Xiong, Patrice Naud, Jiening Xiao, Deanna K Sosnowski, Ewen Le Quilliec, Arnela Saljic, Issam H Abu-Taha, Markus Kamler, Charles-Alexandre LeBlanc, Doa'a G F Al-U'Datt, Martin G Sirois, Terence Hebert, Jean-François Tanguay, Jean-Claude Tardif, Dobromir Dobrev, Stanley Nattel
AIMS: Recent studies suggest that bioactive mediators called resolvins promote active resolution of inflammation. Inflammatory signaling is involved in development of the substrate for atrial fibrillation (AF). To evaluate effects of resolvin-D1 on atrial arrhythmogenic remodeling resulting from left-ventricular dysfunction induced by myocardial infarction (MI) in rats. METHODS AND RESULTS: MI was produced by left anterior descending coronary-artery ligation. Intervention-groups received daily intraperitoneal resolvin-D1, beginning before MI-surgery (early-RvD1) or day-7 post-MI (late-RvD1) and continued until day-21 post-MI...
December 13, 2023: Cardiovascular Research
https://read.qxmd.com/read/38045567/tissue-factor-targeting-peptide-enhances-nanoparticle-binding-and-delivery-of-a-synthetic-specialized-pro-resolving-lipid-mediator-to-injured-arteries
#37
JOURNAL ARTICLE
Elizabeth S Levy, Alexander S Kim, Evan Werlin, Mian Chen, Brian E Sansbury, Matthew Spite, Tejal A Desai, Michael S Conte
BACKGROUND: Specialized pro-resolving lipid mediators (SPM) such as resolvin D1 (RvD1) attenuate inflammation and exhibit vasculo-protective properties. METHODS: We investigated poly-lactic-co-glycolic acid (PLGA)-based nanoparticles (NP), containing a peptide targeted to tissue factor (TF) for delivery of 17R-RvD1 and a synthetic analog 17-R/S-benzo-RvD1 (benzo-RvD1) using in vitro and in vivo models of acute vascular injury. NPs were characterized in vitro by size, drug loading, drug release, TF binding, and vascular smooth muscle cell migration assays...
2023: Journal of vascular surgery. Vascular science
https://read.qxmd.com/read/38040190/resolvin-and-lipoxin-metabolism-network-regulated-by-hyssopus-cuspidatus-boriss-extract-in-asthmatic-mice
#38
JOURNAL ARTICLE
Ping He, Juan Hao, Ling-Fei Kong, Ayidana Wotan, Pan Yan, Yi-Cong Geng, Yi Wang, Zheng-Ying Li, Shi-Xian Hu, Bin Ren, Xiao-Juan Rong, Cai Tie
Resolvin (Rv) and lipoxin (Lx) play important regulative roles in the development of several inflammation-related diseases. The dysregulation of their metabolic network is believed to be closely related to the occurrence and development of asthma. The Hyssopus Cuspidatus Boriss extract (SXCF) has long been used as a treatment for asthma, while the mechanism of anti-inflammatory and anti-asthma action targeting Rv and Lx has not been thoroughly investigated. In this study, we aimed to investigate the effects of SXCF on Rv, Lx in ovalbumin (OVA)-sensitized asthmatic mice...
November 29, 2023: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/38036037/a-new-r-r-rvd6-isomer-with-protective-actions-following-corneal-nerve-injury
#39
REVIEW
Haydee E P Bazan, Thang L Pham
The transparent cornea is the most densely innervated tissue in the body, primarily by sensory nerves originating from the trigeminal ganglia (TG). Damage to corneal nerves reduces sensitivity and tear secretion and results in dry eye. Consequently, ocular pain, for which no satisfactory therapies exist, arises in many cases. Treatment of injured corneas with pigment epithelium-derived factor (PEDF) combined with docosahexaenoic acid (DHA) stimulates nerve regeneration in models of refractive surgery, which damages nerves...
November 28, 2023: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/38035115/arachidonate-15-lipoxygenase-mediated-production-of-resolvin-d5-n-3-dpa-abrogates-pancreatic-stellate-cell-induced-cancer-cell-invasion
#40
JOURNAL ARTICLE
Gabriel A Aguirre, Michelle R Goulart, Jesmond Dalli, Hemant M Kocher
Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to poor prognosis. Specialized pro-resolving mediators (SPMs) are prime modulators of inflammation and its resolution, traditionally thought to be produced by immune cells. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based lipid mediator profiling PSCs as well as primary human CAFs express enzymes and receptors to produce and respond to SPMs...
2023: Frontiers in Immunology
keyword
keyword
31238
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.