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https://www.readbyqxmd.com/read/29319804/effects-of-agricultural-organic-dusts-on-human-lung-resident-mesenchymal-stem-stromal-cell-function
#1
Tara M Nordgren, Kristina L Bailey, Art J Heires, Dawn Katafiasz, Debra J Romberger
Agricultural organic dust exposures trigger harmful airway inflammation, and workers experiencing repetitive dust exposures are at increased risk for lung disease. Mesenchymal stem/stromal cells (MSC) regulate wound repair processes in the lung, and may contribute to either pro-resolution or pro-fibrotic lung responses. It is unknown how organic dust exposures alter lung-resident MSC activation and pro-inflammatory versus pro-repair programs in the lung. To address this gap in knowledge, we isolated human lung-resident MSC from lung tissue...
January 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29312587/tumour-microenvironmental-blood-flow-determines-a-metabolomic-signature-identifying-lysophospholipids-and-resolvin-d-as-biomarkers-in-endometrial-cancer-patients
#2
Núria Eritja, Mariona Jové, Kristine Eldevik Fasmer, Sònia Gatius, Manuel Portero-Otin, Jone Trovik, Camilla Krakstad, Joaquim Sol, Reinald Pamplona, Ingfrid S Haldorsen, Xavier Matias-Guiu
Purpose: We aimed to study the potential influence of tumour blood flow -obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid chromatography coupled to mass spectrometry established the metabolomic profile of endometrial cancer lesions exhibiting high (n=12) or low (n=14) tumour blood flow at DCE-MRI. Univariate and multivariate statistics (ortho-PLS-DA, a random forest (RF) classifier and hierarchical clustering) and receiver operating characteristic (ROC) curves were used to establish a panel for potentially discriminating tumours with high versus low blood flow...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29305860/rvd1-inhibits-tnf%C3%AE-induced-c-myc-expression-in-normal-intestinal-epithelial-cells-and-destabilizes-hyper-expressed-c-myc-in-colon-cancer-cells
#3
Xiancai Zhong, Ha-Na Lee, Young-Joon Surh
Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Seeking the resolution of colitis has been addressed as a new therapeutic strategy to CAC. Resolvin D1 (RvD1) is an endogenous lipid mediator that is generated from docosahexaenoic acid during the resolution of inflammation. Although the pro-resolving effects of RvDs have been extensively investigated and well defined, the role for RvD1 in CAC remains largely unknown...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29302056/human-macrophages-differentially-produce-specific-resolvin-or-leukotriene-signals-that-depend-on-bacterial-pathogenicity
#4
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C Norris, Nan Chiang, Charles N Serhan
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatures when exposed to pathogenic bacteria. E. coli and S. aureus each stimulate predominantly proinflammatory 5-lipoxygenase (LOX) and cyclooxygenase pathways (i.e., leukotriene B4 and prostaglandin E2) in M1 macrophages. These pathogens stimulate M2 macrophages to produce SPMs including resolvin D2 (RvD2), RvD5, and maresin-1...
January 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29279348/international-union-of-basic-and-clinical-pharmacology-ciii-chemerin-receptors-cmklr1-chemerin1-and-gpr1-chemerin2-nomenclature-pharmacology-and-function
#5
Amanda J Kennedy, Anthony P Davenport
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous ligand for a G protein-coupled receptor encoded by the gene CMKLR1 (also known as ChemR23), and as a consequence the receptor protein was renamed the chemerin receptor in 2013. Since then, chemerin has been identified as the endogenous ligand for a second G protein-coupled receptor, encoded by the gene GPR1 Therefore, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification recommends that the official name of the receptor protein for chemokine-like receptor 1 (CMKLR1) is chemerin receptor 1, and G protein-coupled receptor 1 is chemerin receptor 2 to follow the convention of naming the receptor protein after the endogenous ligand...
January 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29235036/expression-of-dha-metabolizing-enzyme-alox15-is-regulated-by-selective-histone-acetylation-in-neuroblastoma-cells
#6
Christabel Fung-Yih Ho, Claire Poh-Ee Bon, Yee-Kong Ng, Deron R Herr, Jui-Sheng Wu, Teng-Nan Lin, Wei-Yi Ong
The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety. In this study, we elucidated epigenetic regulation of Alox15 via histone modifications in neuron-like cells. Treatment of undifferentiated SH-SY5Y human neuroblastoma cells with the histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate significantly increased Alox15 mRNA expression...
December 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29233471/resolvin-d1-regulates-epithelial-ion-transport-and-inflammation-in-cystic-fibrosis-airways
#7
Fiona C Ringholz, Gerard Higgins, Aurélie Hatton, Ali Sassi, Ahmad Moukachar, Coral Fustero-Torre, Monika Hollenhorst, Isabelle Sermet-Gaudelus, Brian J Harvey, Paul McNally, Valerie Urbach
BACKGROUND: Cystic Fibrosis (CF) lung disease is characterised by dysregulated ion transport that promotes chronic bacterial infection and inflammation. The impact of the specialised pro-resolution mediator resolvin D1 (RvD1) on airway surface liquid (ASL) dynamics and innate defence had not yet been investigated in CF airways. METHODS: Ex vivo studies were performed on primary cultures of alveolar macrophages and bronchial epithelial cells from children with CF and in human bronchial epithelial cell lines; in vivo studies were performed in homozygous F508del-CFTR mice treated with vehicle control or RvD1 (1-100nM)...
December 7, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29197557/soy-flour-as-an-alternative-to-purified-lipoxygenase-for-the-enzymatic-synthesis-of-resolvin-analogues
#8
Hoang-Anh T Tu, Eleanor P Dobson, Luke C Henderson, Colin J Barrow, Jacqui L Adcock
Specialized pro-resolving mediators are lipid signaling molecules synthesized from omega-3 and -6 polyunsaturated fatty acids, which promote the resolution of the inflammatory response. They are potential drug targets for the treatment of numerous conditions linked with uncontrolled inflammation. Many of these mediators can be effectively synthesized using enzymes, such as lipoxygenases. However, these enzymes are expensive to purchase and can be difficult to isolate. In this work, we show that commercial soy flour can be used directly as a source of lipoxygenase for the biosynthesis of specialized pro-resolving mediators from DHA and other biologically important fatty acids...
November 29, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29191914/resolvins-suppress-tumor-growth-and-enhance-cancer-therapy
#9
Megan L Sulciner, Charles N Serhan, Molly M Gilligan, Dayna K Mudge, Jaimie Chang, Allison Gartung, Kristen A Lehner, Diane R Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P Sukhatme, Arja Kaipainen, Mark W Kieran, Sui Huang, Dipak Panigrahy
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure...
November 30, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29173199/effects-of-prenatal-n-3-fatty-acid-supplementation-on-offspring-resolvins-at-birth-and-12-years-of-age-a-double-blind-randomised-controlled-clinical-trial
#10
Valene H L See, Emilie Mas, Susan L Prescott, Lawrence J Beilin, Sally Burrows, Anne E Barden, Rae-Chi Huang, Trevor A Mori
Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3·7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29154839/participation-of-the-anti-inflammatory-and-antioxidative-activity-of-docosahexaenoic-acid-on-indomethacin-induced-gastric-injury-model
#11
Elizabeth Arlen Pineda-Peña, Yoalli Martínez-Pérez, Marina Galicia-Moreno, Araceli Navarrete, José Segovia, Pablo Muriel, Liliana Favari, Gilberto Castañeda-Hernández, Aracely Evangelina Chávez-Piña
Adverse gastrointestinal (GI) effects caused by nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin, are recognized as the major limitation to their clinical use. NSAID-induced gastric damage is generated by cyclooxygenase inhibition, activation of inflammatory processes, and oxidative stress. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has shown gastroprotective effects; however, the molecular mechanisms underlying these effects have not been fully explained. As a result, the aim of this study was to examine DHA's anti-inflammatory and antioxidative actions in a mouse model of indomethacin-induced gastric injury...
November 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29137840/resolvin-d1-attenuates-imiquimod-induced-mice-psoriasiform-dermatitis-through-mapks-and-nf-%C3%AE%C2%BAb-pathways
#12
Juntao Xu, Xiaoru Duan, Feng Hu, Devesh Poorun, Xinxin Liu, Xin Wang, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Hongxiang Chen
BACKGROUND: Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE: The present study aimed to determine the protective effects and the underlying mechanisms of RvD1 on imiquimod (IMQ)-induced psoriasiform dermatitis. METHODS: Mice were topically treated with IMQ to develop psoriasiform dermatitis on their shaved back, pretreated intraperitoneally (i...
November 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29134121/omega-3-fatty-acids-in-atherosclerosis-and-coronary-artery-disease
#13
REVIEW
Magnus Bäck
Omega-3 polyunsaturated fatty acids have emerged as possible protective factors associated with a decreased risk for myocardial infarction in populations with a high marine food intake, which may relate to effects on lipid metabolism, thrombosis and inflammation. Omega-3 fatty acids decrease triglyceride levels and also compete as substrates for enzymes involved in the biosynthesis of lipid mediators. The balance between omega-3-derived specialized proresolving mediators and pro-inflammatory lipid mediators from arachidonic acid metabolism can be measured as the resolvin-to-leukotriene ratio, which has been shown to predict subclinical atherosclerosis...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29126887/combined-administration-of-resolvin-e1-and-lipoxin-a4-resolves-inflammation-in-a-murine-model-of-alzheimer-s-disease
#14
Alpdogan Kantarci, Nurgul Aytan, Iro Palaska, Danielle Stephens, Leah Crabtree, Claudia Benincasa, Bruce G Jenkins, Isabel Carreras, Alpaslan Dedeoglu
Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease (AD). In this study, we found that the levels of specialized pro-resolving lipid mediators (SPMs) in the hippocampus of 5xFAD mice are significantly lower than in non-transgenic littermates. We, therefore, tested the hypothesis that treatment with resolvin E1 (RvE1) and lipoxin A4 (LXA4) alone or in combination will reverse the neuroinflammatory process and decrease Aβ pathology. 5xFAD mice were treated intraperitoneally starting at 1month of age with RvE1 or LXA4 alone or in combination at a dose of 1...
November 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29110146/atherosclerosis-periodontal-disease-and-treatment-with-resolvins
#15
REVIEW
James A Hamilton, Hatice Hasturk, Alpdogan Kantarci, Charles N Serhan, Thomas Van Dyke
PURPOSE OF REVIEW: This review aims to discuss the existing evidence on the link between atherosclerosis and periodontitis by particularly presenting new findings that link the pathology and therapy of these diseases. Acute vascular ischemic events that can lead to stroke or myocardial infarction are initiated by inflammatory processes leading to rupture or erosion of plaques susceptible to thrombosis ("high risk" or "vulnerable"). These are highly inflamed plaques residing in the media and adventitia that may not be detected by angiography measurments of luminal narrowing...
November 6, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29109025/fish-oil-feeding-attenuates-neuroinflammatory-gene-expression-without-concomitant-changes-in-brain-eicosanoids-and-docosanoids-in-a-mouse-model-of-alzheimer-s-disease
#16
Kathryn E Hopperton, Marc-Olivier Trépanier, Nicholas C E James, Raphaël Chouinard-Watkins, Richard P Bazinet
BACKGROUND: Neuroinflammation is a recognized hallmark of Alzheimer's disease, along with accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 polyunsaturated fatty acids (PUFA) and molecules derived from them, including eicosapentaenoic acid-derived eicosanoids and docosahexaenoic acid-derived docosanoids, are known to have both anti-inflammatory and pro-resolving properties, while human observational data links consumption of these fatty acids to a decreased risk of Alzheimer's disease...
November 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29103035/immunotherapy-of-mild-cognitive-impairment-by-%C3%AF-3-supplementation-why-are-amyloid-%C3%AE-antibodies-and-%C3%AF-3-not-working-in-clinical-trials
#17
Milan Fiala, Lucas Restrepo, Matteo Pellegrini
This article reviews the basic tenets of a clinical approach to effective immunotherapy of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Although one randomized controlled study in early MCI patients by fish-derived omega-3 fatty acids (ω-3) showed slowing of disease progression, large clinical trials with different products have failed to show cognitive effects. Macrophages of healthy subjects phagocytize and degrade amyloid-β1 - 42 (Aβ) in the brain tissues, whereas macrophages of patients with AD and MCI are functionally defective...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29095817/a-regulatory-role-for-%C3%AE-adrenergic-receptors-regarding-the-resolvin-d1-rvd1-pathway-in-the-diabetic-retina
#18
Haoshen Shi, Thomas W Carion, Youde Jiang, Adam Chahine, Jena J Steinle, Elizabeth A Berger
Diabetic retinopathy is a visually debilitating disease with limited treatment options available. Compound 49b, a β-adrenergic receptor agonist, has been demonstrated to effectively reduce disease pathogenesis associated with diabetic retinopathy. While the exact mechanisms are not fully understood, previous studies have determined that it reduces the pro-inflammatory cytokine, TNF-α, and inhibits apoptosis of the retinal microvasculture. As inflammation becomes more recognized in driving disease pathogenesis, so does the regulation by pro-resolving pathways as therapeutic points of intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29090333/resolvin-e1-e2-ameliorate-lipopolysaccharide-induced-depression-like-behaviors-via-chemr23
#19
Satoshi Deyama, Kento Shimoda, Hiroe Suzuki, Yuka Ishikawa, Kohei Ishimura, Hayato Fukuda, Natsuko Hitora-Imamura, Soichiro Ide, Masamichi Satoh, Katsuyuki Kaneda, Satoshi Shuto, Masabumi Minami
RATIONALE: Resolvins are bioactive lipid mediators that are generated from docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We recently demonstrated that the DHA-derived resolvins D1 and D2 exert antidepressant effects. However, whether the EPA-derived resolvins E1 (RvE1) and E2 (RvE2) produce antidepressant effects is not clear. OBJECTIVES: We examined the antidepressant effects of RvE1/RvE2 in a murine lipopolysaccharide (LPS)-induced depression model using the tail suspension and forced swim tests...
October 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29083412/resolvind1-stimulates-epithelial-wound-repair-and-inhibits-tgf-%C3%AE-induced-emt-whilst-reducing-fibroproliferation-and-collagen-production
#20
Shengxing Zheng, Qian Wang, Vijay D'Souza, Dom Bartis, Rachel Dancer, Dhruv Parekh, Fang Gao, Qingquan Lian, Shengwei Jin, David R Thickett
Acute and chronic inflammatory lung diseases are often associated with epithelial cell injury/loss and fibroproliferative responses. ResolvinD1 (RvD1) is biosynthesized during the resolution phase of inflammatory response and exerts potent anti-inflammatory and promotes resolution of inflammatory lung diseases. The aim of this study was to investigate whether RvD1 exerts protective effects on alveolar epithelial cell function/differentiation and protects against fibroproliferative stimuli. Primary human alveolar type II cells were used to model the effects of RvD1 in vitro upon wound repair, proliferation, apoptosis, transdifferentiation, and epithelial-mesenchymal transition (EMT)...
October 30, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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