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https://www.readbyqxmd.com/read/28263773/discovery-of-specialized-pro-resolving-mediators-marks-the-dawn-of-resolution-physiology-and-pharmacology
#1
REVIEW
Charles N Serhan
It is with great pleasure that I write this foreword and introduction to this Special Issue dedicated to the protective actions of the pro-resolving mediators and edited by my colleague Dr. Jesmond Dalli. Many of my collaborators and colleagues that helped to uncover the actions and clinical potential of the resolvins and other specialized proresolving mediators (SPM), namely, the superfamily of pro-resolving mediators that includes the resolvin (E-series, D-series and DPA-derived), protectin and maresin families, as well as the arachidonic acid-derived lipoxins, join me in this special issue...
March 3, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28259922/signal-transduction-involved-in-lipoxin-a4%C3%A2-induced-protection-of-tubular-epithelial-cells-against-hypoxia-reoxygenation-injury
#2
Sheng-Hua Wu, Ming-Jie Wang, Jing Lü, Xiao-Qing Chen
Previous studies have reported that lipoxin A4 (LXA4) may exert a renoprotective effect on ischemia/reperfusion injury in various animal models. The underlying mechanism of LXA4‑induced renoprotection during ischemia/reperfusion injury remains to be elucidated. The present study investigated LXA4‑induced protection on renal tubular cells subjected to hypoxia/reoxygenation (H/R) injury, and determined the effects of peroxisome proliferator‑activated receptor‑γ (PPARγ) and heme oxygenase‑1 (HO‑1) on LXA4 treatment...
February 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28257820/specialized-pro-resolving-mediators-in-cardiovascular-diseases
#3
REVIEW
Gabrielle Fredman, Matthew Spite
The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recruitment of neutrophils, and promote the clearance of dead cells by macrophages. These mediators also enhance host-defense and couple resolution of inflammation to subsequent phases of tissue repair...
February 28, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28245134/nlrp3-inflammasome-deficiency-protects-against-microbial-sepsis-via-increased-lipoxin-b4-synthesis
#4
Seonmin Lee, Kiichi Nakahira, Jesmond Dalli, Ilias I Siempos, Paul C Norris, Romain A Colas, Jong-Seok Moon, Masakazu Shinohara, Shu Hisata, Judie Ann Howrylak, Gee-Young Suh, Stefan W Ryter, Charles N Serhan, Augustine M K Choi
RATIONALE: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a major public health concern with high mortality and morbidity. Although inflammatory responses triggered by infection are crucial for host defense against invading microbes, the excessive inflammation often causes tissue damage leading to organ dysfunction. Resolution of inflammation, an active immune process mediated by endogenous lipid mediators (LMs), is important to maintain host homeostasis...
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28241993/arachidonic-acid-and-lipoxina4-attenuate-streptozotocin-induced-cytotoxicity-to-rin5-f%C3%A2-cells-in%C3%A2-vitro-and-type-1-and-type-2-diabetes-mellitus-in%C3%A2-vivo
#5
Naveen K V Gundala, Vegi G M Naidu, Undurti N Das
OBJECTIVE: The aim of this study was to observe whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5 F) cells against streptozotocin (STZ)-induced apoptosis in vitro and type 1 diabetes mellitus (T1DM) and type 2 DM (T2DM) in vivo and if so, what would be the mechanism of this action. METHODS: RIN5 F cells were used for the in vitro study, whereas the in vivo study was performed in Wistar rats. STZ was used to induce apoptosis of RIN5 F cells in vitro and T1- and T2DM in vivo...
March 2017: Nutrition
https://www.readbyqxmd.com/read/28241480/pro-resolving-molecules-new-approaches-to-treat-sepsis
#6
REVIEW
Christa Buechler, Rebekka Pohl, Charalampos Aslanidis
Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches to down-modulate mediators relevant for the onset and duration of inflammation are successful in some chronic diseases, while all of them have failed in sepsis patients. Inflammation and immune suppression characterize sepsis, indicating that anti-inflammatory strategies alone are inappropriate for its therapy...
February 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28237084/identification-and-profiling-of-specialized-pro-resolving-mediators-in-human-tears-by-lipid-mediator-metabolomics
#7
Justin T English, Paul C Norris, Robin R Hodges, Darlene A Dartt, Charles N Serhan
Specialized pro-resolving mediators (SPM), e.g. Resolvin D1, Protectin D1, Lipoxin A₄, and Resolvin E1 have each shown to be active in ocular models reducing inflammation. In general, SPMs have specific agonist functions that stimulate resolution of infection and inflammation in animal disease models. The presence and quantity of SPM in human emotional tears is of interest. Here, utilizing a targeted LC-MS-MS metabololipidomics based approach we document the identification of pro-inflammatory (Prostaglandins and Leukotriene B₄) and pro-resolving lipid mediators (D-series Resolvins, Protectin D1, and Lipoxin A₄) in human emotional tears from 12 healthy individuals...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28218740/maresin1-stimulates-alveolar-fluid-clearance-through-the-alveolar-epithelial-sodium-channel-na-k-atpase-via-the-alx-pi3k-nedd4-2-pathway
#8
Jun-Li Zhang, Xiao-Jun Zhuo, Jing Lin, Ling-Chun Luo, Wei-Yang Ying, Xiang Xie, Hua-Wei Zhang, Jing-Xiang Yang, Dan Li, Fang Gao Smith, Sheng-Wei Jin
Maresin1 (MaR1) is a new docosahexaenoic acid-derived pro-resolving agent that promotes the resolution of inflammation. In this study, we sought to investigate the effect and underlining mechanisms of MaR1 in modulating alveolar fluid clearance (AFC) on LPS-induced acute lung injury. MaR1 was injected intravenously or administered by instillation (200 ng/kg) 8 h after LPS (14 mg/kg) administration and AFC was measured in live rats. In primary rat alveolar type II epithelial cells, MaR1 (100 nM) was added to the culture medium with lipopolysaccharide for 6 h...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28218420/plasma-lipoxin-a4-and-resolvin-d1-are-not-associated-with-reduced-adenoma-risk-in-a-randomized-trial-of-aspirin-to-prevent-colon-adenomas
#9
Veronika Fedirko, Gail McKeown-Eyssen, Charles N Serhan, Elizabeth L Barry, Robert S Sandler, Jane C Figueiredo, Dennis J Ahnen, Robert S Bresalier, Douglas J Robertson, Carlton W Anderson, John A Baron
Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A4 (LXA4 ) and resolvin D1(RvD1)] with risk for recurrent adenoma. In this pilot study, we used data and biosamples from an adenoma chemoprevention study investigating the effects of aspirin and/or folic acid on the occurrence of colorectal adenomas...
February 20, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28210259/resolution-of-cancer-promoting-inflammation-a-new-approach-for-anticancer-therapy
#10
REVIEW
Qi Zhang, Bo Zhu, Yongsheng Li
Inflammation is a protective response that eliminates harmful stimuli and restores tissue homeostasis, whereas the failure to resolve inflammation leads to the development of malignancies. Immune cells in the tumor inflammatory microenvironment endow cancer cells with their specific hallmarks, including mutations, metabolic reprograming, angiogenesis, invasion, and metastasis. Targeting the inflammatory microenvironment with anti-inflammatory drugs (e.g., aspirin) or by enhancing antitumor immunity (e.g., chimeric antigen receptor T cell therapy) has been extensively investigated and has achieved promising results in many cancers...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28209487/lipoxin-a4-suppresses-osteoclastogenesis-in-raw264-7-cells-and-prevents-ovariectomy-induced-bone-loss
#11
Changyu Liu, Hanfeng Guan, Cong Cai, Feng Li, Jun Xiao
Lipoxin A4 (LXA4; 5S, 6R, 15Strihydroxy- 7,9,13-trans-11-eicosatetraenoic acid) is a metabolic product of arachidonic acid under the action of lipoxidase. This lipid molecule plays important roles in several biological functions, especially inflammatory processes. In vivo, LXA4 regulates the inflammatory response through several signaling pathways. Its mechanism suggests that it might have an effect on osteoclastogenesis and bone loss. Using both in vitro and in vivo studies, it was here observed that LXA4 could significantly inhibit the formation and function of osteoclasts and these effects could be blocked by Boc-2, the specific inhibitor of FPR2/ALX (the receptor of LXA4)...
March 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28191524/renin-angiotensin-aldosterone-system-in-insulin-resistance-and-metabolic-syndrome
#12
Undurti N Das
Obesity and its consequent complications such as hypertension and metabolic syndrome are increasing in incidence in almost all countries. Insulin resistance is common in obesity. Renin- angiotensin system (RAS) is an important target in the treatment of hypertension and drugs that act on RAS improve insulin resistance and decrease the incidence of type 2 diabetes mellitus, explaining the close association between hypertension and type 2 diabetes mellitus. RAS influences food intake by modulating the hypothalamic expression of neuropeptide Y and orexins via AMPK dephosphorylation...
June 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28158236/pro-resolving-lipid-mediator-resolvin-d1-serves-as-a-marker-of-lung-disease-in-cystic-fibrosis
#13
Olaf Eickmeier, Daniela Fussbroich, Klaus Mueller, Friederike Serve, Christina Smaczny, Stefan Zielen, Ralf Schubert
BACKGROUND: Cystic fibrosis (CF) is an autosomal recessive genetic disorder that affects multiple organs, including the lungs, pancreas, liver and intestine. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) locus lead to defective proteins and reduced Cl- secretion and Na+ hyperabsorption in the affected organs. In addition, patients suffering from CF display chronic inflammation that contributes to the pathogenesis of CF. Recent work suggests that CF patients have a reduced capacity to biosynthesize specialized pro-resolving lipid mediators (SPMs), which contributes to the development and duration of the unwanted inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28144281/lipoxin-a4-as-a-possible-mediator-of-the-beneficial-actions-of-phosphodiesterase-5-enzyme-inhibitors
#14
Undurti N Das
No abstract text is available yet for this article.
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28132398/modulation-of-antiphospholipid-antibodies-induced-trophoblast-damage-by-different-drugs-used-to-prevent-pregnancy-morbidity-associated-with-antiphospholipid-syndrome
#15
Angela M Alvarez, Norman Balcázar, Sebastián San Martín, Udo R Markert, Angela P Cadavid
PROBLEM: Women with antiphospholipid antibodies (aPLs) present a risk of pregnancy morbidity (PM), vascular thrombosis (VT), or both (PM/VT). aPLs affect trophoblast function, and the aim of this study was to determine the modulation of this aPL-induced damage by different drugs. METHOD OF STUDY: IgG was obtained from women with PM and PM/VT positive to aPLs. Binding of IgG to trophoblastic cells, proliferation, mitochondrial membrane integrity, and trophoblast invasion were assessed...
January 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28119539/inflammatory-mechanisms-in-tendinopathy-towards-translation
#16
REVIEW
Neal L Millar, George A C Murrell, Iain B McInnes
Tendinopathy is a multifactorial spectrum of tendon disorders that affects different anatomical sites and is characterized by activity-related tendon pain. These disorders are common, account for a high proportion (∼30%) of referrals to musculoskeletal practitioners and confer a large socioeconomic burden of disease. Our incomplete understanding of the mechanisms underpinning tendon pathophysiology continues to hamper the development of targeted therapies, which have been successful in other areas of musculoskeletal medicine...
January 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28109294/probing-the-intermolecular-interactions-of-ppar%C3%AE-lbd-with-polyunsaturated-fatty-acids-and-their-anti-inflammatory-metabolites-to-infer-most-potential-binding-moieties
#17
Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das
BACKGROUND: PPARγ is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPARγ receptor is found to play a crucial role in the modulation of lipid and glucose homeostasis. Its commotion has been reported to play a significant role in a broad spectrum of diseases such as type 2 diabetes mellitus, inflammatory diseases, Alzheimer's disease, and in some cancers. Hence, PPARγ is an important therapeutic target. Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARγ...
January 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#18
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28089732/alox15-as-a-suppressor-of-inflammation-and-cancer-lost-in-the-link
#19
REVIEW
Rui Tian, Xiangsheng Zuo, Jonathan Jaoude, Fei Mao, Jennifer Colby, Imad Shureiqi
Mounting evidence supports a mechanistic link between inflammation and cancer, especially colon cancer. ALOX15 (15-lipoxygenase-1) plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation. ALOX15 expression is downregulated in colorectal cancer (CRC). Intestinally-targeted transgenic expression of ALOX15 in mice inhibited dextran sodium sulfate-induced colitis from promoting azoxymethane- induced colorectal tumorigenesis, demonstrating that ALOX15 can suppress inflammation-driven promotion of carcinogen-induced colorectal tumorigenesis and therefore ALOX15 downregulation during tumorigenesis is likely to enhance the link between colitis and colorectal tumorigenesis...
January 12, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28087575/treating-inflammation-and-infection-in-the-21st-century-new-hints-from-decoding-resolution-mediators-and-mechanisms
#20
REVIEW
Charles N Serhan
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity, and asthma, as well as classic inflammatory diseases (e...
January 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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