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https://www.readbyqxmd.com/read/27887602/combination-of-aspirin-with-essential-fatty-acids-is-superior-to-aspirin-alone-to-prevent-or-ameliorate-sepsis-or-ards
#1
EDITORIAL
Undurti N Das
It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4). Our previous studies revealed that plasma phospholipid content of arachidonic acid (AA) and eicosapentaenoic acid (EPA) is low in patients with sepsis. This implies that beneficial actions of aspirin in sepsis and ARDS is unlikely to be obtained in view of deficiency of AA and EPA, the precursors of LXA4 and resolvins respectively that are potent anti-inflammatory compounds and enhancers of eNO generation...
November 25, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27877134/modulation-of-the-activities-of-neuronal-ion-channels-by-fatty-acid-derived-pro-resolvents
#2
REVIEW
Geunyeol Choi, Sun Wook Hwang
Progress of inflammation depends on the balance between two biological mechanisms: pro-inflammatory and pro-resolving processes. Many extracellular and intracellular molecular components including cytokines, growth factors, steroids, neurotransmitters, and lipidergic mediators and their receptors contribute to the two processes, generated from cellular participants during inflammation. Fatty acid-derived mediators are crucial in directing the inflammatory phase and orchestrating heterogeneous reactions of participants such as inflamed cells, innate immune cells, vascular components, innervating neurons, etc...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27872283/correction-for-adel-et-al-evolutionary-alteration-of-alox15-specificity-optimizes-the-biosynthesis-of-antiinflammatory-and-proresolving-lipoxins
#3
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27872282/correction-to-supporting-information-for-adel-et-al-evolutionary-alteration-of-alox15-specificity-optimizes-the-biosynthesis-of-antiinflammatory-and-proresolving-lipoxins
#4
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27862450/arachidonic-acid-and-lipoxin-a4-attenuate-alloxan-induced-cytotoxicity-to-rin5f-cells-in-vitro-and-type-1-diabetes-mellitus-in-vivo
#5
Naveen K V Gundala, Vegi G M Naidu, Undurti N Das
OBJECTIVE: We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5F) cells against alloxan-induced apoptosis in vitro and type 1 diabetes mellitus (type 1 DM) in vivo and if so, mechanism of this beneficial action. MATERIAL AND METHODS: In vitro study was conducted using RIN5F cells while in vivo study was performed in Wistar rats. The effect of PUFAs, cyclo-oxygenase and lipoxygenase inhibitors, various eicosanoids and PUFAs metabolites: lipoxin A4 (LXA4), resolvin D2 and protectin against alloxan-induced cytotoxicity to RIN5F cells and type 1 DM was studied...
November 15, 2016: BioFactors
https://www.readbyqxmd.com/read/27849643/comparison-of-rectal-indomethacin-diclofenac-and-naproxen-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#6
Amir H Mohammad Alizadeh, Mohammad Abbasinazari, Behzad Hatami, Saeed Abdi, Forozan Ahmadpour, Shideh Dabir, Aida Nematollahi, Samira Fatehi, Mohammad A Pourhoseingholi
BACKGROUND AND AIM: NSAIDs are commonly utilized for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, not much is known about the most effective drug in preventing this complication. This study aims to clarify which drug (indomethacin, diclofenac, or naproxen) is most effective for the prevention of post endoscopic retrograde cholangiopancreatography (ERCP). MATERIALS AND METHODS: In a double-blind, randomized study, patients received a single rectal dose of one of the three drugs 30 min before undergoing ERCP: diclofenac (100 mg), indomethacin (100 mg), or naproxen (500 mg)...
November 15, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27824117/lipoxin-a4-counter-regulates-histamine-stimulated-glycoconjugate-secretion-in-conjunctival-goblet-cells
#7
Robin R Hodges, Dayu Li, Marie A Shatos, Charles N Serhan, Darlene A Dartt
Conjunctival goblet cells synthesize and secrete mucins which play an important role in protecting the ocular surface. Pro-resolution mediators, such as lipoxin A4 (LXA4), are produced during inflammation returning the tissue to homeostasis and are also produced in non-inflamed tissues. The purpose of this study was to determine the actions of LXA4 on cultured human conjunctival goblet cell mucin secretion and increase in intracellular [Ca(2+)] ([Ca(2+)]i) and on histamine-stimulated responses. LXA4 increased mucin secretion and [Ca(2+)]i, and activated ERK1/2 in human goblet cells...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821556/amnion-epithelial-cells-promote-lung-repair-via-lipoxin-a4
#8
Jean L Tan, Yan Z Tan, Ruth Muljadi, Siow T Chan, Sin N Lau, Joanne C Mockler, Euan M Wallace, Rebecca Lim
: : Human amnion epithelial cells (hAECs) have been shown to possess potent immunomodulatory properties across a number of disease models. Recently, we reported that hAECs influence macrophage polarization and activity, and that this step was dependent on regulatory T cells. In this study, we aimed to assess the effects of hAEC-derived proresolution lipoxin-A4 (LXA4) on T-cell, macrophage, and neutrophil phenotype and function during the acute phase of bleomycin-induced lung injury. Using C57Bl6 mice, we administered 4 million hAECs intraperitoneally 24 hours after bleomycin challenge...
November 7, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27819165/lipoxin-a4-lxa4-as-a-potential-first-trimester-biochemical-marker-of-intrauterine-growth-disorders
#9
Michał Lipa, Dorota Bomba-Opoń, Jacek Lipa, Paweł Bartnik, Zbigniew Bartoszewicz, Mirosław Wielgoś
OBJECTIVE: To evaluate first trimester maternal serum levels of lipoxin A4 (LXA4) in prediction of intrauterine fetal growth. METHODS: Study group of 185 patients in singleton pregnancy divided into 3 subgroups according to neonatal birthweight: ≤10 th percentile (SGA), 11- 89th percentile (AGA) and ≥90 percentile (LGA). RESULTS: We observed decreased values of LXA4 concentations, both in SGA- and LGA groups, when compared to AGA (68.91±33...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27791009/maresin-conjugates-in-tissue-regeneration-biosynthesis-enzymes-in-human-macrophages
#10
Jesmond Dalli, Iliyan Vlasakov, Ian R Riley, Ana R Rodriguez, Bernd W Spur, Nicos A Petasis, Nan Chiang, Charles N Serhan
Macrophages are central in coordinating immune responses, tissue repair, and regeneration, with different subtypes being associated with inflammation-initiating and proresolving actions. We recently identified a family of macrophage-derived proresolving and tissue regenerative molecules coined maresin conjugates in tissue regeneration (MCTR). Herein, using lipid mediator profiling we identified MCTR in human serum, lymph nodes, and plasma and investigated MCTR biosynthetic pathways in human macrophages. With human recombinant enzymes, primary cells, and enantiomerically pure compounds we found that the synthetic maresin epoxide intermediate 13S,14S-eMaR (13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid) was converted to MCTR1 (13R-glutathionyl, 14S-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Z-docosahexaenoic acid) by LTC4S and GSTM4...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27776459/plant-sterol-enriched-soy-milk-consumption-modulates-5-lipoxygenase-12-lipoxygenase-and-myeloperoxidase-activities-in-healthy-adults-a-randomised-controlled-trial-%C3%A2-%C3%A2
#11
Xing Lin Ho, Jonathan Jia He Liu, Wai Mun Loke
A randomized, double blind, placebo-controlled and crossover study was conducted to simultaneously measure the effects, after 3-hour and 4-week daily exposure to plant sterols-enriched food product, on inflammation, oxidative status, 5-lipoxygenase, 12-lipoxygenase and myeloperoxidase activities in healthy adults. Eighteen healthy participants (67% female, 35.3 (mean)±9.5 (SD) years, mean body mass index 22.8 kg m(-2)) received 2 soy milk (20g) treatments daily: placebo and one containing 2.0g free plant sterols equivalent of their palmitates (β-sitosterol, 55%; campesterol, 29% and stigmasterol, 23%)...
October 24, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27742828/cytokine-induced-glucocorticoid-resistance-from-eosinophil-activation-protein-phosphatase-5-modulation-of-glucocorticoid-receptor-phosphorylation-and-signaling
#12
Konrad Pazdrak, Christof Straub, Rosario Maroto, Susan Stafford, Wendy I White, William J Calhoun, Alexander Kurosky
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocorticoid signaling in in vitro activated eosinophils. An annexin V assay used to measure eosinophil apoptosis showed that cytokine combinations of IL-2 plus IL-4 as well as TNF-α plus IFN-γ, or IL-3, GM-CSF, and IL-5 alone significantly diminished the proapoptotic response to dexamethasone...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27732897/immobilization-and-delivery-of-biologically-active-lipoxin-a4-using-electrospinning-technology
#13
Eleonora Cianci, Oriana Trubiani, Francesca Diomede, Ilaria Merciaro, Ida Meschini, Pantaleone Bruni, Fausto Croce, Mario Romano
Lipoxin (LX)A4 is a lipoxygenase-formed arachidonic acid metabolite with potent anti-inflammatory, pro-resolution properties. Its therapeutic efficacy has been largely demonstrated in a variety of cellular, preclinical and clinical models. Among these, periodontal disease, where LXA4 promotes tissue repair, also by modulating functions of human periodontal ligament stem cells (hPDLSCs). As medicated biomembranes may be particularly useful in clinical settings, where local stimulation of tissue repair is needed, we used electrospinning to embed LXA4 in membranes made of poly(ethylene oxide) (PEO) and poly(d,l-lactide) (PDLLA)...
October 11, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27684428/an-acute-retinal-model-for-evaluating-blood-retinal-barrier-breach-and-potential-drugs-for-treatment
#14
Hao Wu, Ana R Rodriguez, Bernd W Spur, Venkat Venkataraman
A low-cost, easy-to-use and powerful model system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach. An inflammatory factor, histamine, is demonstrated to compromise vessel integrity in the cultured retina through positive staining of IgG outside of the blood vessels. The effects of histamine itself and those of candidate drugs for potential treatments, such as lipoxin A4, are assessed using three parameters: blood vessel leakage via IgG immunostaining, activation of Müller cells via GFAP staining and change in neuronal dendrites through staining for MAP2...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27681120/altering-the-anti-inflammatory-lipoxin-microenvironment-a-new-insight-into-kshv-pathogenesis
#15
Jayashree A Chandrasekharan, Xiao M Huang, Alexandar Hwang, Neelam Sharma-Walia
: Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's Sarcoma (KS) and Primary Effusion Lymphoma (PEL) are two well-known inflammation related diseases caused by Kaposi's Sarcoma-Associated Herpesvirus (KSHV). Controlling inflammation is one of the strategies adopted to treat KS and PEL, a primary motivation for exploring and evaluating the therapeutic potential of using lipoxins...
September 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27663891/dioxin-like-rather-than-non-dioxin-like-pcbs-promote-the-development-of-endometriosis-through-stimulation-of-endocrine-inflammation-interactions
#16
Qiansheng Huang, Yajie Chen, Qionghua Chen, Huanteng Zhang, Yi Lin, Maobi Zhu, Sijun Dong
Polychlorinated biphenyls (PCBs) contain 209 congeners with various structure-activities. Exposure to PCBs was related to disorders of female reproduction. Endometriosis (EM) is an estrogen- and inflammation-dependent disease with high prevalence and severe health outcomes. Epidemiological studies have shown the effects of PCBs exposure on EM in regard to various structures of PCBs. However, little evidence is available from the toxicology considering the structure of PCBs. In the study, environmentally relevant concentrations of PCBs were used to treat primary cultured endometrial cells and an EM mouse model...
September 23, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27647830/signaling-and-immunoresolving-actions-of-resolvin-d1-in-inflamed-human-visceral-adipose-tissue
#17
Esther Titos, Bibiana Rius, Cristina López-Vicario, José Alcaraz-Quiles, Verónica García-Alonso, Aritz Lopategi, Jesmond Dalli, Juan José Lozano, Vicente Arroyo, Salvadora Delgado, Charles N Serhan, Joan Clària
Persistent activation of the innate immune system greatly influences the risk for developing metabolic complications associated with obesity. In this study, we explored the therapeutic potential of the specialized proresolving mediator (SPM) resolvin D1 (RvD1) to actively promote the resolution of inflammation in human visceral adipose tissue from obese (Ob) patients. Using liquid chromatography-tandem mass spectrometry-based metabololipidomic analysis, we identified unbalanced production of SPMs (i.e., D- and E-series resolvins, protectin D1, maresin 1, and lipoxins) with respect to inflammatory lipid mediators (i...
October 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27643598/role-of-lta4h-polymorphism-in-tuberculosis-associated-immune-reconstitution-inflammatory-syndrome-occurrence-and-clinical-severity-in-patients-infected-with-hiv
#18
Gopalan Narendran, Dhanasekaran Kavitha, Ramesh Karunaianantham, Leonardo Gil-Santana, Jilson L Almeida-Junior, Sirasanambatti Devarajulu Reddy, Marimuthu Makesh Kumar, Haribabu Hemalatha, Nagesh Nalini Jayanthi, Narayanan Ravichandran, Raja Krishnaraja, Angamuthu Prabhakar, Tamizhselvan Manoharan, Lokeswaran Nithyananthan, Gunasundari Arjunan, Mohan Natrajan, Soumya Swaminathan, Bruno B Andrade
BACKGROUND: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide polymorphism (SNP) in the LTA4H promoter which regulates its transcriptional activity (rs17525495) has been identified and described to impact clinical severity of TB presentation and response to corticosteroid therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27630217/lipoxin-a4-a-5-lipoxygenase-pathway-metabolite-modulates-immune-response-during-acute-respiratory-tularemia
#19
Anju Singh, Tabassum Rahman, Rose Bartiss, Alireza Arabshahi, Jeevan Prasain, Stephen Barnes, Florin Marcel Musteata, Timothy J Sellati
Respiratory infection with Francisella tularensis (Ft) is characterized by a muted, acute host response, followed by sepsis-like syndrome that results in death. Infection with Ft establishes a principally anti-inflammatory environment that subverts host-cell death programs to facilitate pathogen replication. Although the role of cytokines has been explored extensively, the role of eicosanoids in tularemia pathogenesis is not fully understood. Given that lipoxin A4 (LXA4) has anti-inflammatory properties, we investigated whether this lipid mediator affects host responses manifested early during infection...
September 14, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27615282/lipoxin-a4-selectively-programs-the-profile-of-m2-tumor-associated-macrophages-which-favour-control-of-tumor-progression
#20
R L Simões, N M De-Brito, H Cunha-Costa, V Morandi, I M Fierro, I M Roitt, C Barja-Fidalgo
In tumor microenvironments, the macrophage population is heterogeneous, but some macrophages can acquire tumor-promoting characteristics. These tumor-associated macrophages (TAM) exhibit an M2-like profile, with deficient production of NO and ROS, characteristics of pro-inflammatory M1 cytotoxic macrophages. Lipoxins (LX) and 15-epi-lipoxins are lipid mediators which can induce certain features of M2 macrophages in mononuclear cells, but their effects on TAM remain to be elucidated. This study tested the hypothesis that ATL-1, a synthetic analogue of 15-epi-lipoxin A4 , could modulate TAM activity profile...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
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