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https://www.readbyqxmd.com/read/28594958/the-effects-of-different-frequency-treadmill-exercise-on-lipoxin-a4-and-articular-cartilage-degeneration-in-an-experimental-model-of-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#1
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, Lunhao Bai
The aim was to investigate the effects of different frequencies treadmill exercise with total exercise time being constancy on articular cartilage, lipoxin A4 (LXA4) and the NF-κB pathway in rat model of monosodium iodoacetate-induced osteoarthritis (OA). Fifty male Sprague-Dawley rats were randomly divided into five groups (n = 10): controls (CG), knee OA model (OAG), OA + treadmill exercise once daily (OAE1), OA + treadmill exercise twice daily, rest interval between exercise>4h (OAE2) and OA + treadmill exercise three times daily, rest interval between exercise>4h (OAE3)...
2017: PloS One
https://www.readbyqxmd.com/read/28532687/the-role-of-systemic-and-topical-fatty-acids-for-dry-eye-treatment
#2
REVIEW
Stefano Barabino, Jutta Horwath-Winter, Elisabeth M Messmer, Maurizio Rolando, Pasquale Aragona, Shigeru Kinoshita
Dry eye is a prevalent condition and one of the main reasons for patients to seek ophthalmic medical care. A low systemic level of omega fatty acids is a risk factor for dry eye disease (DED). There are two groups of essential fatty acids (EFAs): the omega-6 (n-6) family and the omega-3 (n-3) family. Humans evolved on a diet in which the n-6:n-3 ratio was approximately 1:1, however the current Western diet tends to be deficient in n-3 EFAs and this ratio is typically much higher (approaching 17:1). The metabolism of EFAs generates four new families of local acting mediators: lipoxins, resolvins, protectins, and maresins...
May 19, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28527709/boosting-inflammation-resolution-in-atherosclerosis-the-next-frontier-for-therapy
#3
REVIEW
Gabrielle Fredman, Ira Tabas
Defective inflammation resolution is the underlying cause of prevalent chronic inflammatory diseases, such as arthritis, asthma, cancer, and neurodegenerative and cardiovascular diseases. Inflammation resolution is governed by several endogenous factors, including fatty acid-derived specialized proresolving mediators and proteins, such as annexin A1. Specifically, specialized proresolving mediators comprise a family of mediators that include arachidonic acid-derived lipoxins, omega-3 fatty acid eicosapentaenoic acid-derived resolvins, docosahexaenoic acid-derived resolvins, protectins, and maresins...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28523230/targeting-resolution-of-neuroinflammation-after-ischemic-stroke-with-a-lipoxin-a4-analog-protective-mechanisms-and-long-term-effects-on-neurological-recovery
#4
Kimberly E Hawkins, Kelly M DeMars, Jon C Alexander, Lauren G de Leon, Sean C Pacheco, Christina Graves, Changjun Yang, Austin O McCrea, Jan C Frankowski, Timothy J Garrett, Marcelo Febo, Eduardo Candelario-Jalil
BACKGROUND: Resolution of inflammation is an emerging new strategy to reduce damage following ischemic stroke. Lipoxin A4 (LXA 4) is an anti-inflammatory, pro-resolution lipid mediator that reduces neuroinflammation in stroke. Since LXA 4 is rapidly inactivated, potent analogs have been synthesized, including BML-111. We hypothesized that post-ischemic, intravenous treatment with BML-111 for 1 week would provide neuroprotection and reduce neurobehavioral deficits at 4 weeks after ischemic stroke in rats...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522438/anti-inflammatory-effects-of-oxpapc-involve-endothelial-cell-mediated-generation-of-lxa4
#5
Yunbo Ke, Noureddine Zebda, Olga Oskokova, Taras Afonyushkin, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov
Rationale: Oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine generates a group of bioactive oxidized phospholipid products (OxPAPC) with a broad range of biological activities. Barrier-enhancing and anti-inflammatory effects of OxPAPC on pulmonary endothelial cells (EC) are critical for prevention of acute lung injury caused by bacterial pathogens or excessive mechanical ventilation. Anti-inflammatory properties of OxPAPC are associated with its antagonistic effects on toll-like receptors and suppression of RhoA GTPase signaling...
May 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28507800/formyl-peptide-receptor-1-suppresses-gastric-cancer-angiogenesis-and-growth-by-exploiting-inflammation-resolution-pathways
#6
Nella Prevete, Federica Liotti, Anna Illiano, Angela Amoresano, Piero Pucci, Amato de Paulis, Rosa Marina Melillo
Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising from the metabolic activity of lipoxygenases (ALOX5/15) on ω-6 or ω-3 essential polyunsaturated fatty acids (PUFA). We previously demonstrated that formyl peptide receptor 1 (FPR1) suppresses gastric cancer (GC) by inhibiting its inflammatory/angiogenic potential. In this study, we asked whether FPR1 exploits inflammation resolution pathways to suppress GC angiogenesis and growth...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28492741/effect-of-alox-15-polymorphism-on-gcf-levels-of-lipoxin-a4-in-chronic-periodontitis-a-preliminary-study
#7
Fouzia Tarannum, Mohamed Faizuddin
Lipoxins play an important role in periodontal resolution, hence, investigation of genetic polymorphism of lipoxin gene may provide important information on the role of lipoxins in periodontal disease pathogenesis. The aim of this study was to investigate a polymorphism of C-to-T substitution at position c.-292 in ALOX15 (reticulocyte-type 15 lipoxygenase 1) gene in patients with chronic periodontitis and to associate the polymorphism with gingival crevicular fluid (GCF) lipoxin A4 (LXA4) levels. Forty-five chronic periodontitis and 45 periodontally healthy patients were included in this case-control study...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28487436/protective-effect-of-let-7-mirna-family-in-regulating-inflammation-in-diabetes-associated-atherosclerosis
#8
Eoin Brennan, Bo Wang, Aaron McClelland, Muthukumar Mohan, Mariam Marai, Ophelie Beuscart, Sinda Derouiche, Stephen Gray, Raelene Pickering, Chris Tikellis, Monica de Gaetano, Mary Barry, Orina Belton, Syed Tasadaque Ali-Shah, Patrick Guiry, Karin Am Jandeleit-Dahm, Mark E Cooper, Catherine Godson, Phillip Kantharidis
The let-7 miRNA family play a key role in modulating inflammatory responses. Vascular smooth muscle cell (SMC) proliferation, and endothelial cell (EC) dysfunction are critical in the pathogenesis of atherosclerosis, including in the setting of diabetes. Here we report that let-7 levels are decreased in diabetic human carotid plaques and in a model of diabetes-associated atherosclerosis (DAA), the diabetic ApoE(-/-) mouse. In vitro, platelet-derived growth factor (PDGF) and tumor necrosis factor-alpha (TNF-α) induced vascular SMC and EC activation was associated with reduced let-7 miRNA expression, via Lin28b, a negative regulator of let-7 biogenesis...
May 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28485793/lipoxin-a4-mitigates-experimental-autoimmune-myocarditis-by-regulating-inflammatory-response-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathway-in-mice
#9
Y Shi, H Pan, H-Z Zhang, X-Y Zhao, J Jin, H-Y Wang
OBJECTIVE: Myocarditis, an acute inflammation disease of the heart, is a potentially lethal disease and can lead to sudden death. This study aims to investigate the therapeutic effect of lipoxin A4 (LXA4) on experimental autoimmune myocarditis (EAM) and to explore the underlying mechanism. MATERIALS AND METHODS: EAM was induced in BALB/c mice by injection of porcine cardiac myosin and LAX4 at doses of 10 or 50 μg/kg was administrated from day 1 to 21. The severity of myocarditis was evaluated by detection of heart weight/body weight (HW/BW) ratio and histopathological examination of the heart...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28483532/pro-resolving-mediators-in-the-regulation-of-periodontal-disease
#10
REVIEW
Thomas E Van Dyke
Periodontitis is an inflammatory disease of the supporting structures of the dentition that is initiated by bacteria that form a biofilm on the surface of the teeth. The pathogenesis of the disease is a result of complex interactions between the biofilm and the host response that results in dysbiosis of the microbiome and dysregulation of the inflammatory response. Current data suggest that the excess inflammation associated with periodontitis is due to a failure of resolution of inflammation pathways. In this review, the relationship between inflammation and microbial dysbiosis is examined in the context of pro-inflammation and pro-resolution mediators and their ability to modify the course of disease...
May 18, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28471519/mast-cells-mediate-early-neutrophil-recruitment-and-exhibit-anti-inflammatory-properties-via-fpr2-alx
#11
Ellen L Hughes, Felix Becker, Roderick J Flower, Julia C Buckingham, Felicity N E Gavins
BACKGROUND AND PURPOSE: In recent years, studies have focused on the resolution of inflammation, which can be achieved by endogenous anti-inflammatory agonists such as Annexin A1 (AnxA1). Here, we investigated the effects of mast cells (MCs) on early lipopolysaccharide (LPS)-induced neutrophil recruitment and the involvement of the AnxA1-Formyl peptide receptor 2/ALX (Fpr2/ALX or lipoxin A4 receptor) pathway. EXPERIMENTAL APPROACH: Intravital microscopy (IVM) was used to visualize and quantify the effects of LPS (10 µg per mouse i...
May 4, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28450270/pro-resolution-therapeutics-for-cardiovascular-diseases
#12
REVIEW
Justin Heinz, Michael Marinello, Gabrielle Fredman
Studies over the last couple of decades suggest that failed resolution of a chronic inflammatory response is an important driving force in the progression of atherosclerosis. Resolution of inflammation is mediated in part by lipid-derived specialized pro-resolving mediators (SPMs) such as lipoxins, resolvins, protectins and maresins. The major functions of SPMs are to quell inflammation and repair tissue damage in a manner that does not compromise host defense. An imbalance between SPMs and pro-inflammatory mediators like leukotriene B4 (LTB4) are associated with several prevalent human diseases, including atherosclerosis...
April 24, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28438799/erratum-for-gonz%C3%A3-lez-herrera-et-al-simvastatin-attenuates-endothelial-activation-through-15-epi-lipoxin-a4-production-in-murine-chronic-chagas-cardiomyopathy
#13
Fabiola González-Herrera, Allysson Cramer, Pollyana Pimentel, Christian Castillo, Ana Liempi, Ulrike Kemmerling, Fabiana S Machado, Juan D Maya
No abstract text is available yet for this article.
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28412216/hydroalcoholic-crude-extract-of-casearia-sylvestris-sw-reduces-chronic-post-ischemic-pain-by-activation-of-pro-resolving-pathways
#14
Anna P Piovezan, Ana P Batisti, Maria L A C S Benevides, Bruna L Turnes, Daniel F Martins, Luiz Kanis, Elisa C W Duarte, Alberto J Cavalheiro, Paula C P Bueno, Michael P Seed, Lucy V Norling, Dianne Cooper, Sarah Headland, Patrícia R P S Souza, Mauro Perretti
ETHNOPHARMACOLOGICAL RELEVANCE: Casearia sylvestris Sw. is widely used in popular medicine to treat conditions associated with pain. AIM OF THE STUDY: The present study investigated the influence of hydroalcoholic crude extract of Casearia sylvestris (HCE-CS) and contribution of pro-resolving mediators on mechanical hyperalgesia in a mouse model of chronic post-ischemia pain (CPIP). METHODS AND RESULTS: Male Swiss mice were subjected to ischemia of the right hind paw (3h), then reperfusion was allowed...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28407017/characterizing-the-anti-inflammatory-and-tissue-protective-actions-of-a-novel-annexin-a1-peptide
#15
Mauro Perretti, Clara Di Filippo, Michele D'Amico, Jesmond Dalli
Inflammation in now appreciated to be at the centre of may diseases that affect Western civilization. Current therapeutics for managing these conditions may interfere with the host response leading to immune suppression. We recently developed an annexin (Anx) A1-derived peptide, coined CR-AnxA12-50, which displays potent pro-resolving and tissue protective actions. Herein, we designed a novel peptide using CR-AnxA12-50 as a template that was significantly more resistant to neutrophil-mediated degradation. This peptide, termed CR-AnxA12-48, retained high affinity and specificity to the pro-resolving Lipoxin A4 receptor (ALX) with an IC50 of ~20nM...
2017: PloS One
https://www.readbyqxmd.com/read/28386340/lipoxin-a4-pretreatment-mitigates-skeletal-muscle-ischemia-reperfusion-injury-in-rats
#16
Haiyang Zong, Xinghui Li, Haodong Lin, Chunlin Hou, Fenfen Ma
The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery followed by 3 h of reperfusion. Treatment with LA4 significantly ameliorated histological damage scores in I/R-injured skeletal muscle. LA4 treatment resulted in remarkable decreases in the wet weight/dry weight ratio (W/D ratio), inflammatory response, oxidative stress, and cell apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28371562/amnion-epithelial-cells-promote-lung-repair-via-lipoxin-a4
#17
Jean L Tan, Yan Z Tan, Ruth Muljadi, Siow T Chan, Sin N Lau, Joanne C Mockler, Euan M Wallace, Rebecca Lim
Human amnion epithelial cells (hAECs) have been shown to possess potent immunomodulatory properties across a number of disease models. Recently, we reported that hAECs influence macrophage polarization and activity, and that this step was dependent on regulatory T cells. In this study, we aimed to assess the effects of hAEC-derived proresolution lipoxin-A4 (LXA4) on T-cell, macrophage, and neutrophil phenotype and function during the acute phase of bleomycin-induced lung injury. Using C57Bl6 mice, we administered 4 million hAECs intraperitoneally 24 hours after bleomycin challenge...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28360907/aspirin-the-mechanism-of-action-revisited-in-the-context-of-pregnancy-complications
#18
REVIEW
Angela P Cadavid
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities, including analgesic, antipyretic, and antiplatelet properties. Currently, it is accepted to prescribe a low dose of aspirin to pregnant women who are at high risk of preeclampsia (PE) because it reduces the onset of this complication. Another pregnancy alteration in which a low dose of aspirin is recommended is the obstetric antiphospholipid syndrome (APS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28336292/structural-elucidation-and-physiologic-functions-of-specialized-pro-resolving-mediators-and-their-receptors
#19
REVIEW
Nan Chiang, Charles N Serhan
The acute inflammatory response is host-protective to contain foreign invaders. Many of today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious unwanted side effects such as immune suppression. Uncontrolled inflammation is now considered a pathophysiologic basis associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as well as the classic inflammatory diseases, e.g. arthritis, periodontal diseases...
March 31, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28263773/discovery-of-specialized-pro-resolving-mediators-marks-the-dawn-of-resolution-physiology-and-pharmacology
#20
REVIEW
Charles N Serhan
It is with great pleasure that I write this foreword and introduction to this Special Issue dedicated to the protective actions of the pro-resolving mediators and edited by my colleague Dr. Jesmond Dalli. Many of my collaborators and colleagues that helped to uncover the actions and clinical potential of the resolvins and other specialized proresolving mediators (SPM), namely, the superfamily of pro-resolving mediators that includes the resolvin (E-series, D-series and DPA-derived), protectin and maresin families, as well as the arachidonic acid-derived lipoxins, join me in this special issue...
March 3, 2017: Molecular Aspects of Medicine
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