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Lipoxin

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https://www.readbyqxmd.com/read/29787808/lipoxin-a-4-and-its-analog-suppress-hepatocarcinoma-cell-epithelial-mesenchymal-transition-migration-and-metastasis-via-regulating-integrin-linked-kinase-axis
#1
Fen Xu, Xiaoyan Zhou, Jian Hao, Hua Dai, Jian Zhang, Yuanqiao He, Hua Hao
Epithelial-mesenchymal Transition (EMT) and migration play an important role in tumor progression, and lipoxin (LX), the 'stop signal' for inflammation, has been studied in basic research for its anti-inflammatory or inflammatory pro-resolving properties. Here, in the in vitro experiment, we showed that LXA4 could inhibit the EMT and migration in phorbol myristate acetate (PMA) or activated conditioned medium (ACM)-stimulated Hep3B cells by downregulation of integrin-linked kinase (ILK), a pseudokinase in cytoplasm and these effects were via inhibiting the phosphorylation of Akt and GSK3β...
May 19, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29786049/lipoxin-a4-ameliorates-lipopolysaccharide-induced-a549-cell-injury-through-upregulation-of-n-myc-downstream-regulated-gene-1
#2
Jun-Zhi Zhang, Zhan-Li Liu, Yao-Xian Zhang, Hai-Jiu Lin, Zhong-Jun Zhang
Background: Lipoxin A4 (LXA4) can alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) and acute respiratory distress syndrome through promoting epithelial sodium channel (ENaC) expression in lung epithelial cells. However, how LXA4 promote ENaC expression is still largely elusive. The present study aimed to explore genes and signaling pathway involved in regulating ENaC expression induced by LXA4. Methods: A549 cells were incubated with LPS and LXA4, or in combination, and analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) of ENaC-α/γ...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29782179/early-intravascular-events-are-associated-with-development-of-ards
#3
Raja-Elie E Abdulnour, Tina Gunderson, Ioanna Barkas, Jack Y Timmons, Cindy Barnig, Michelle Gong, Daryl J Kor, Ognjen Gajic, Daniel Talmor, Rickey E Carter, Bruce D Levy
RATIONALE: The acute respiratory distress syndrome (ARDS) is a devastating illness with limited therapeutic options. A better understanding of early biochemical and immunological events in ARDS could inform the development of new preventive and treatment strategies. OBJECTIVE: To determine select peripheral blood lipid mediator and leukocyte responses in patients at-risk for ARDS. METHODS: Patients at risk for ARDS were randomized as part of a multicenter, double-blind clinical trial of aspirin versus placebo (LIPS-A; NCT01504867)...
May 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29733875/neuroinflammation-markers-and-methyl-alcohol-induced-toxic-brain-damage
#4
Sergey Zakharov, Jiri Hlusicka, Olga Nurieva, Katerina Kotikova, Lucie Lischkova, Petr Kacer, Tereza Kacerova, Pavel Urban, Manuela Vaneckova, Zdenek Seidl, Pavel Diblik, Pavel Kuthan, Jarmila Heissigerova, Jiri Lesovsky, Jan Rulisek, Lucie Vojtova, Jaroslav A Hubacek, Tomas Navratil
Methyl alcohol intoxication is a global problem with high mortality and long-term visual sequelae and severe brain damage in survivors. The role of neuroinflammation in the mechanisms of methyl alcohol-induced toxic brain damage has not been well studied. We measured the acute concentrations and dynamics of lipoxins LxA4 and LxB4 and the interleukins IL-4, IL-5, IL-9, IL-10, and IL-13 in the serum of patients treated with methyl alcohol poisoning and the follow-up concentrations in survivors two years after discharge from the hospital...
May 4, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29733849/dexmedetomidine-restores-septic-renal-function-via-promoting-inflammation-resolution-in-a-rat-sepsis-model
#5
Rongzong Qiu, Weifeng Yao, Haocong Ji, Dongdong Yuan, Xiaofeng Gao, Weiping Sha, Fei Wang, Pinjie Huang, Ziqing Hei
BACKGROUND: Acute kidney injury occurred after sepsis, resulting in high mortality. This research aims to elucidate the mechanistic effect of DEX on the renal inflammation resolution during sepsis in rats. METHODS: The rats were randomly divided into a sham group and the other three cecal ligation and puncture (CLP) model groups, based on different treatments: placebo, DEX and 2-adrenergic receptor (AR) inhibitor atipamezole (AT) treatment (DEX + AT) groups...
May 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29731194/lipoxin-a4-inhibits-uv-radiation-induced-skin-inflammation-and-oxidative-stress-in-mice
#6
R M Martinez, V Fattori, P Saito, C B P Melo, S M Borghi, I C Pinto, A J C Bussmann, M M Baracat, S R Georgetti, W A Verri, R Casagrande
BACKGROUND: Lipoxin A4 (LXA4 ) is a metabolic product of arachidonic acid. Despite potent anti-inflammatory and pro-resolution activities, it remains to be determined if LXA4 has effect on ultraviolet (UV) radiation-induced skin inflammation. OBJECTIVE: To investigate the effects of systemic administration with LXA4 on UV radiation-induced inflammation and oxidative damage in the skin of mice. METHODS: Varied parameters of inflammation and oxidative stress in the skin of mice were evaluated after UV radiation (4...
April 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29730187/identification-of-proresolving-and-inflammatory-lipid-mediators-in-human-psoriasis
#7
Alexander V Sorokin, Paul C Norris, Justin T English, Amit K Dey, Abhishek Chaturvedi, Yvonne Baumer, Joanna Silverman, Martin P Playford, Charles N Serhan, Nehal N Mehta
BACKGROUND: Psoriasis (PSO) is an immune-mediated inflammatory disease associated with metabolic and cardiovascular comorbidities. It is now known that resolution of inflammation is an active process locally controlled by specialized proresolving mediators (SPMs), named resolvins (Rvs), protectins, and maresins. OBJECTIVE: It is unknown whether these potent lipid mediators (LMs) are involved in PSO pathophysiology and if the skin and blood have disease-specific SPMs phenotype profiles...
April 6, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29707294/lipoxin-a4-regulates-pm2-5-induced-severe-allergic-asthma-in-mice-via-the-th1-th2-balance-of-group-2-innate-lymphoid-cells
#8
Xiaoxia Lu, Huicong Fu, Feng Han, Yurong Fang, Jiali Xu, Liqiong Zhang, Qing Du
Background: Urban particulate matter (PM) contributes to the increasing number of people with asthma, which is closely related to the development of industrialization. Especially, PM with an aerodynamic diameter of <2.5 µm (PM2.5) enhances the risk of damaging respiratory organs. It has reported that PM2.5-induced pathological changes could be considered as a remarkable molecular mechanism of PM2.5-mediated cytotoxicity in respiratory disease and even lung cancer. Methods: In this study, we have investigated the effects of PM2...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29704485/bml-111-alleviates-acute-lung-injury-through-regulating-the-expression-of-lncrna-malat1
#9
Hongbin Li, Huijuan Shi, Ning Ma, Panpan Zi, Qilong Liu, Rongqing Sun
BML-111 is a lipoxin receptor agonist that plays a vital role on inflammation. MALAT1 is reported to mediate lung injury. ALI rat model was established using the method of venous cannula. Pulmonary microvascular endothelial cells (PMVEC) of rats were isolated using immunomagnetic separation method. Hematoxylin-eosin (HE) staining was performed to observe the lung injury degree. Real-time PCR and western blot were performed to detect the genes expression. ELIAS was used to determine the level of TNF-α and IL-6...
April 25, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29696149/anti-inflammatory-benefits-of-antibiotics-tylvalosin-induces-apoptosis-of-porcine-neutrophils-and-macrophages-promotes-efferocytosis-and-inhibits-pro-inflammatory-cxcl-8-il1%C3%AE-and-ltb-4-production-while-inducing-the-release-of-pro-resolving-lipoxin-a-4-and-resolvin
#10
Ruth Moges, Dimitri Desmonts De Lamache, Saman Sajedy, Bernard S Renaux, Morley D Hollenberg, Gregory Muench, Elizabeth M Abbott, Andre G Buret
Excessive accumulation of neutrophils and their uncontrolled death by necrosis at the site of inflammation exacerbates inflammatory responses and leads to self-amplifying tissue injury and loss of organ function, as exemplified in a variety of respiratory diseases. In homeostasis, neutrophils are inactivated by apoptosis, and non phlogistically removed by neighboring macrophages in a process known as efferocytosis, which promotes the resolution of inflammation. The present study assessed the potential anti-inflammatory and pro-resolution benefits of tylvalosin, a recently developed broad-spectrum veterinary macrolide derived from tylosin...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29684359/the-g-protein-coupled-receptor-alx-fpr2-regulates-adaptive-immune-responses-in-mouse-submandibular-glands
#11
Ching-Shuen Wang, Olga J Baker
ALX/FPR2 is a G-protein-coupled receptor that has multiple binding partners, including the endogenous lipid mediators resolvin D1 (RvD1), lipoxin A4 (LXA4 ), and the Ca2+ -dependent phospholipid-binding protein Annexin A1. Previous studies demonstrated that RvD1 activates ALX/FPR2 to resolve salivary gland inflammation in the NOD/ShiLtJ mouse model for Sjögren's syndrome. Moreover, mice lacking the ALX/FPR2 display an exacerbated salivary gland inflammation in response to lipopolysaccharide. Additionally, activation of ALX/FPR2 has been shown to be important for regulating antibody production in B cells...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29664060/specialized-pro-resolving-mediators-regulate-alveolar-fluid-clearance-during-acute-respiratory-distress-syndrome
#12
REVIEW
Qian Wang, Song-Fan Yan, Yu Hao, Sheng-Wei Jin
Objective: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by the injury of alveolar epithelium, which impairs active fluid transport in the lung, and impedes the reabsorption of edema fluid from the alveolar space. This review aimed to discuss the role of pro-resolving mediators on the regulation of alveolar fluid clearance (AFC) in ARDS. Data Sources: Articles published up to September 2017 were selected from the PubMed, with the keywords of "alveolar fluid clearance" or "lung edema" or "acute lung injury" or "acute respiratory distress syndrome", and "specialized pro-resolving mediators" or "lipoxin" or "resolvin" or "protectin" or "maresin" or "alveolar epithelial cells" or "aspirin-triggered lipid mediators" or "carbon monoxide and heme oxygenase" or "annexin A1"...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29662056/neuronal-sphk1-acetylates-cox2-and-contributes-to-pathogenesis-in-a-model-of-alzheimer-s-disease
#13
Ju Youn Lee, Seung Hoon Han, Min Hee Park, Bosung Baek, Im-Sook Song, Min-Koo Choi, Yoh Takuwa, Hoon Ryu, Seung Hyun Kim, Xingxuan He, Edward H Schuchman, Jae-Sung Bae, Hee Kyung Jin
Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer's disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that neurons in the brains of patients with AD and AD mice show reduction of sphingosine kinase1 (SphK1), leading to defective microglial phagocytosis and dysfunction of inflammation resolution due to decreased secretion of specialized proresolving mediators (SPMs). Elevation of SphK1 increased SPMs secretion, especially 15-R-Lipoxin A4, by promoting acetylation of serine residue 565 (S565) of cyclooxygenase2 (COX2) using acetyl-CoA, resulting in improvement of AD-like pathology in APP/PS1 mice...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29563331/pro-resolving-mediators-promote-resolution-in-a-human-skin-model-of-uv-killed-escherichia-coli-driven-acute-inflammation
#14
Madhur P Motwani, Romain A Colas, Marc J George, Julia D Flint, Jesmond Dalli, Angela Richard-Loendt, Roel Ph De Maeyer, Charles N Serhan, Derek W Gilroy
While the treatment of inflammatory disorders is generally based on inhibiting factors that drive onset of inflammation, these therapies can compromise healing (NSAIDs) or dampen immunity against infections (biologics). In search of new antiinflammatories, efforts have focused on harnessing endogenous pathways that drive resolution of inflammation for therapeutic gain. Identification of specialized pro-resolving mediators (SPMs) (lipoxins, resolvins, protectins, maresins) as effector molecules of resolution has shown promise in this regard...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29524409/metabololipidomic-profiling-of-functional-immunoresolvent-clusters-and-eicosanoids-in-mammalian-tissues
#15
Paul C Norris, Charles N Serhan
Metabolomics enables a systems approach to interrogate the bioactive mediators, their pathways and further metabolites involved in the physiology and pathophysiology of human and animal tissues. New metabololipidomic approaches with mass spectrometry presented in this brief review can now be utilized for the identification and profiling of lipid mediator networks that control inflammation-resolution in human blood and healthy and diseased solid tissues. Coagulation of blood is a protective response that prevents excessive bleeding on injury of blood vessels...
March 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29523657/15-epi-lipoxin-a-4-resolvin-d2-and-resolvin-d3-induce-nf-%C3%AE%C2%BAb-regulators-in-bacterial-pneumonia
#16
Ho Pan Sham, Katherine H Walker, Raja-Elie E Abdulnour, Nandini Krishnamoorthy, David N Douda, Paul C Norris, Ioanna Barkas, Sarah Benito-Figueroa, Jennifer K Colby, Charles N Serhan, Bruce D Levy
Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive tissue damage and promote the resolution of acute inflammation. Mechanisms for NF-κB regulation by SPMs remain to be determined. In this study, after LPS challenge, the SPMs 15-epi-lipoxin A4 (15-epi-LXA4 ), resolvin D1, resolvin D2, resolvin D3, and 17-epi-resolvin D1 were produced in vivo in murine lungs. In LPS-activated human bronchial epithelial cells, select SPMs increased expression of the NF-κB regulators A20 and single Ig IL-1R-related molecule (SIGIRR)...
April 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29511119/splenic-leukocytes-define-the-resolution-of-inflammation-in-heart-failure
#17
Ganesh V Halade, Paul C Norris, Vasundhara Kain, Charles N Serhan, Kevin A Ingle
Inflammation promotes healing in myocardial infarction but, if unresolved, leads to heart failure. To define the inflammatory and resolving responses, we quantified leukocyte trafficking and specialized proresolving mediators (SPMs) in the infarcted left ventricle and spleen after myocardial infarction, with the goal of distinguishing inflammation from its resolution. Our data suggest that the spleen not only served as a leukocyte reservoir but also was the site where SPMs were actively generated after coronary ligation in mice...
March 6, 2018: Science Signaling
https://www.readbyqxmd.com/read/29499974/specialized-proresolving-mediators-enhancing-nonalcoholic-steatohepatitis-and-fibrosis-resolution
#18
REVIEW
Giovanni Musso, Roberto Gambino, Maurizio Cassader, Elena Paschetta, Antonio Sircana
The resolution of necroinflammation and fibrosis remains a primary clinical target in nonalcoholic steatohepatitis (NASH), the most common chronic liver disease and a major cause of end-stage liver disease. Our understanding of the basic molecular mechanisms driving inflammation and fibrosis and their resolution in obesity-related conditions, including NASH, have led to the proposal of a novel, tractable therapeutic paradigm involving specialized proresolving mediators (SPMs), namely lipoxins (LXs), resolvins (Rvs), protectins (PDs), and maresins (MaRs)...
April 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29499280/lipoxin-a4-may-attenuate-the-progression-of-obesity-related-glomerulopathy-by-inhibiting-nf-%C3%AE%C2%BAb-and-erk-p38-mapk-dependent-inflammation
#19
Yan-Ping Guo, Hong-Kun Jiang, Hong Jiang, Hong-Yu Tian, Lei Li
OBJECTIVES: To investigate the effects of lipoxin A4 (LXA4) on inflammatory responses in obesity-related glomerulopathy (ORG) mouse model and its potential mechanisms. METHODS: Male C57BL/6 mice were randomly divided into 4 groups: normal, model, LXA4, and LXA4/Boc-2 groups (n = 8). Mice in LXA4 group were intraperitoneally injected with LXA4 (40 ng/kg) once daily for 3 days following 12 weeks of high-fat diet (HFD) feeding. LXA4 receptor antagonist, Boc-2, was administered in LXA4/Boc-2 group prior to LXA4 treatment to block the effects of LXA4...
April 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29490938/lipoxins-regulate-the-early-growth-response-1-network-and-reverse-diabetic-kidney-disease
#20
Eoin P Brennan, Muthukumar Mohan, Aaron McClelland, Christos Tikellis, Mark Ziemann, Antony Kaspi, Stephen P Gray, Raelene Pickering, Sih Min Tan, Syed Tasadaque Ali-Shah, Patrick J Guiry, Assam El-Osta, Karin Jandeleit-Dahm, Mark E Cooper, Catherine Godson, Phillip Kantharidis
Background The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that promote the physiologic resolution of inflammation suggests that these bioactions may have therapeutic potential in the context of chronic inflammation. Lipoxins (LXs) are lipid mediators that promote the resolution of inflammation. Methods We investigated the potential of LXA4 and a synthetic LX analog (Benzo-LXA4 ) as therapeutics in a murine model of diabetic kidney disease, ApoE-/- mice treated with streptozotocin...
May 2018: Journal of the American Society of Nephrology: JASN
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