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https://www.readbyqxmd.com/read/28444368/simultaneous-targeting-of-multiple-gene-homeologues-to-alter-seed-oil-production-in-camelina-sativa
#1
J A Aznar-Moreno, T P Durrett
The ability to easily transform Camelina sativa with biosynthetic enzymes derived from other plants has made this oil seed crop an ideal platform for the production of unusual lipids valuable for different applications. However, in addition to expressing transgenic enzymes, the suppression of endogenous enzyme activity to reduce competition for common substrates or cofactors is also required to enhance the production of target compounds. As camelina possesses a relatively undifferentiated hexaploid genome, up to three gene homeologues can encode for any particular enzymatic activity, complicating efforts to alter endogenous biosynthetic pathways...
April 21, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28440820/a-pre-strain-strategy-for-developing-a-highly-stretchable-and-foldable-one-dimensional-conductive-cord-based-on-a-ag-nanowire-network
#2
Areum Kim, Jihoon Ahn, Hyewon Hwang, Eunsong Lee, Jooho Moon
A highly stretchable and foldable conductive cord was developed by depositing silver nanowires (AgNWs) on a polyurethane cord. The application of pre-strain to the cord during the deposition of AgNWs resulted in the formation of a wrinkled AgNW layer, thereby inducing structural stability towards stretching and bending. This conductive cord exhibited stable electric conduction under strain values of up to 167% and at a bending radius of 0.3 mm. Also, it could withstand a stretching test of 500 cycles at a strain of 50%...
April 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28438303/relation-of-the-bilateral-earlobe-crease-to-endothelial-dysfunction
#3
Nozomu Oda, Tatsuya Maruhashi, Shinji Kishimoto, Masato Kajikawa, Yumiko Iwamoto, Akimichi Iwamoto, Shogo Matsui, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Ayumu Nakashima, Kensuke Noma, Harutoyo Hirano, Yukihito Higashi
The presence of an earlobe crease (ELC) may be a simple sign to predict atherosclerosis. We evaluated the relation between ELC and vascular function. We measured flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) and observed bilateral earlobes in 400 consecutive subjects. At first, the subjects were divided into 3 groups: non-ELC group, unilateral ELC group, and bilateral ELC group. FMD and NID were significantly lower in the unilateral and bilateral ELC groups than those in the non-ELC group...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28434230/single-layer-graphene-membranes-withstand-ultrahigh-applied-pressure
#4
Luda Wang, Christopher M Williams, Michael S H Boutilier, Piran R Kidambi, Rohit Karnik
High mechanical strength is essential for pressure-driven membrane separations with nanoporous single-layer graphene, but its ability to withstand high pressures remains to be demonstrated. We monitored failure of centimeter-scale single-layer graphene membranes on porous supports subjected to high pressures. Consistent with theory, the membranes were found to withstand higher pressures when placed on porous supports with smaller pore diameters, but failure occurred over a surprisingly broad range of pressures, attributed to heterogeneous susceptibility to failure at wrinkles, defects, and slack in the suspended graphene...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28430445/controlling-the-roughness-of-langmuir-blodgett-monolayers
#5
Gregory J Silverberg, Arthur A McClelland, Sarah Griesse-Nascimento, Camille Girabawe, Julian P Kadow, Lakshminarayanan Mahadevan, Chad David Vecitis
Controlling the surface roughness of thin films with nanoscale precision is of significant interest for the rational design of surface coatings. Although wrinkling and buckling of Langmuir monolayers under compression has been demonstrated for several years, there is currently no method to precisely control this behavior during compression and thereby modify the surface roughness of deposited films. Here, we combine conventional Langmuir phase analysis with a novel dynamic viscoelasticity measurement to simply and accurately observe the jamming transition of monolayers of silica spheres, graphene oxide, and surfactant...
April 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28429495/moisture-responsive-wrinkling-surfaces-with-tunable-dynamics
#6
Songshan Zeng, Rui Li, Stephan G Freire, Vivian M M Garbellotto, Emily Y Huang, Andrew T Smith, Cong Hu, William R T Tait, Zichao Bian, Guoan Zheng, Dianyun Zhang, Luyi Sun
The wrinkle dynamics (such as reversibility and stability) of human skin are affected by the external stimuli, as well as the skin's structure and mechanical properties. Inspired by these tunable responses, three types of moisture-responsive wrinkle dynamics are achieved, for the first time, through a single film-substrate system. These dynamics include: (1) completely reversible wrinkles formation; (2) irreversible wrinkles formation I: the initially formed wrinkles can be permanently erased and never reappear; and (3) irreversible wrinkles formation II: once the wrinkles form, they can no longer be erased...
April 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28427139/-advances-in-the-research-of-mechanism-in-prevention-and-treatment-of-scar-with-botulinum-toxin-type-a-and-its-clinical-application
#7
Y H Li, J Q Liu, D Xiao, W Zhang, D H Hu
Scar is a common complication in wound healing process, and how to effectively prevent and treat it is a hot and difficult problem in burns and plastic surgery field. Botulinum toxin type A is a neurotoxin that has been widely and effectively used in the cosmetic surgery field such as anti-wrinkle and thin face. In recent years, botulinum toxin type A has been applied in prevention and treatment of scar, which causes a great concern. Nowadays, the relevant reports have gradually increased, and the mechanisms have been explored more deeply...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28426934/from-permeation-to-cluster-arrays-graphene-on-ir-111-exposed-to-carbon-vapor
#8
Charlotte Herbig, Timo Knispel, Sabina Simon, Ulrike A Schröder, Antonio J Martínez-Galera, Mohammad A Arman, Christian Teichert, Jan Knudsen, Arkady V Krasheninnikov, Thomas Michely
Our scanning tunneling microscopy and X-ray photoelectron spectroscopy experiments along with first-principles calculations uncover the rich phenomenology and enable a coherent understanding of carbon vapor interaction with graphene on Ir(111). At high temperatures, carbon vapor not only permeates to the metal surface but also densifies the graphene cover. Thereby, in addition to underlayer graphene growth, upon cool down also severe wrinkling of the densified graphene cover is observed. In contrast, at low temperatures the adsorbed carbon largely remains on top and self-organizes into a regular array of fullerene-like, thermally highly stable clusters that are covalently bonded to the underlying graphene sheet...
April 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28421656/oral-intake-of-boesenbergia-pandurata-extract-improves-skin-hydration-gloss-and-wrinkling-a-randomized-double-blind-and-placebo-controlled-study
#9
Do Un Kim, Hee Chul Chung, Changhee Kim, Jae-Kwan Hwang
BACKGROUND: Photoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (UV) irradiation. Chronically, UV-irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, Boesenbergia pandurata (B. pandurata) and its active compound panduratin A showed antiphotoaging activities in vitro and in vivo. OBJECTIVE: The aim of this study was to investigate the clinical efficacy of B...
April 18, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28420996/chronic-water-pipe-smoke-exposure-induces-injurious-effects-to-reproductive-system-in-male-mice
#10
Badreldin H Ali, Khalid A Al Balushi, Mohammed Ashique, Asem Shalaby, Mohammed A Al Kindi, Sirin A Adham, Turan Karaca, Sumaya Beegam, Priya Yuvaraju, Abderrahim Nemmar
There is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term exposure. Here, we assessed effects of WPS exposure (30 min/day) in male mice for 6 months. Control mice were exposed to air-only for the same period of time. Twenty-four hours after the last exposure, testicular histopathology, and markers of inflammation and oxidative stress, and the tyrosine-protein kinase vascular endothelial growth factor receptor 1 (VEGFR1) were assessed in testicular homogenates...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28418519/association-of-diet-with-skin-histological-features-in-uv-b-exposed-mice
#11
Tapan K Bhattacharyya, Yvonne Hsia, David M Weeks, Tatiana K Dixon, Jessica Lepe, J Regan Thomas
Importance: Long-term exposure to solar radiation produces deleterious photoaging of the skin. It is not known if diet can influence skin photoaging. Objectives: To study the influence of a calorie-restricted diet and an obesity diet in mice exposed to long-term UV-B irradiation to assess if there is an association between diet and histopathological response to UV-B irradiation. Design, Setting, and Participants: In this animal model study in an academic setting, the dorsal skin of SKH1 hairless mice receiving normal, calorie-restricted, and obesity diets was exposed to UV-B irradiation 3 times a week for 10 weeks and were compared with corresponding controls...
April 13, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28417901/tunable-bending-stiffness-of-mose2-wse2-heterobilayers-from-flexural-wrinkling
#12
Yufeng Guo, Jiapeng Qiu, Wanlin Guo
Understanding the mechanical behaviors of van der Waals heterogeneous 2D materials is important for their actual applications. Our extensive first-principles calculations and continuum mechanical modeling on the wrinkling of MoSe2/WSe2 heterobilayers caused by compression reveal that the bending stiffness of MoSe2/WSe2 wrinkles strongly depend on the wrinkle structures, which first increase and then decrease with increasing the compressive strain. The bending stiffness of MoSe2/WSe2 wrinkles could be effectively mediated and tuned by adjusting the wrinkle geometry and size...
May 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28415040/green-fluorescent-proteins-induce-oxidative-stress-in-cells-a-worrisome-new-wrinkle-in-the-application-of-the-gfp-reporter-system-to-biological-systems
#13
EDITORIAL
Balaraman Kalyanaraman, Jacek Zielonka
No abstract text is available yet for this article.
March 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28409271/unique-presentation-of-cutis-laxa-with-leigh-like-syndrome-due-to-echs1-deficiency
#14
S Balasubramaniam, L G Riley, D Bratkovic, D Ketteridge, N Manton, M J Cowley, V Gayevskiy, T Roscioli, M Mohamed, T Gardeitchik, E Morava, J Christodoulou
Clinical finding of cutis laxa, characterized by wrinkled, redundant, sagging, nonelastic skin, is of growing significance due to its occurrence in several different inborn errors of metabolism (IEM). Metabolic cutis laxa results from Menkes syndrome, caused by a defect in the ATPase copper transporting alpha (ATP7A) gene; congenital disorders of glycosylation due to mutations in subunit 7 of the component of oligomeric Golgi (COG7)-congenital disorders of glycosylation (CDG) complex; combined disorder of N- and O-linked glycosylation, due to mutations in ATPase H+ transporting V0 subunit a2 (ATP6VOA2) gene; pyrroline-5-carboxylate reductase 1 deficiency; pyrroline-5-carboxylate synthase deficiency; macrocephaly, alopecia, cutis laxa, and scoliosis (MACS) syndrome, due to Ras and Rab interactor 2 (RIN2) mutations; transaldolase deficiency caused by mutations in the transaldolase 1 (TALDO1) gene; Gerodermia osteodysplastica due to mutations in the golgin, RAB6-interacting (GORAB or SCYL1BP1) gene; and mitogen-activated pathway (MAP) kinase defects, caused by mutations in several genes [protein tyrosine phosphatase, non-receptor-type 11 (PTPN11), RAF, NF, HRas proto-oncogene, GTPase (HRAS), B-Raf proto-oncogene, serine/threonine kinase (BRAF), MEK1/2, KRAS proto-oncogene, GTPase (KRAS), SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), leucine rich repeat scaffold protein (SHOC2), NRAS proto-oncogene, GTPase (NRAS), and Raf-1 proto-oncogene, serine/threonine kinase (RAF1)], which regulate the Ras-MAPK cascade...
April 13, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28406731/protein-expression-level-of-skin-wrinkle-related-factors-in-hairless-mice-fed-hyaluronic-acid
#15
Min-Kyu Yun, Sung-Jin Lee, Hye-Jin Song, Heui-Jong Yu, Chan Su Rha, Dae-Ok Kim, Soo-Young Choe, Johann Sohn
The aim of this study was to evaluate the wrinkle improving effect of hyaluronic acid intakes. Wrinkles were induced by exposing the skin of hairless mice to ultraviolet B (UVB) irradiation for 14 weeks. Hyaluronic acid was administered to the mice for 14 weeks including 4 weeks before experiments. Skin tissue was assayed by enzyme-linked immunosorbent assay to determine protein expression of wrinkle-related markers. The group supplemented with high concentrations of hyaluronic acid appeared significantly better than control group for collagen, matrix metalloproteinase 1, interleukin (IL)-1β, and IL-6 assay...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28403271/clinical-assessment-of-immediate-and-long-term-effects-of-a-two-step-topical-hyaluronic-acid-lip-treatment
#16
Elizabeth T Makino, Priscilla Tan, Kun Qian, Michael Babcock, Rahul C Mehta
<p>Key features of lip aging include loss of volume, color, and definition as well as increases in lines/wrinkles and uneven skin texture. A single-center, open-label clinical study was conducted to assess the efficacy and tolerability of a novel, topical two-step lip treatment (HA5 LS) in female subjects presenting with mild to moderate lip dryness and mild to severe lip condition. Subjects were instructed to apply HA5 LS at least three times a day to ensure coverage 8 hours a day for four weeks. Clinical assessments for efficacy and tolerability were conducted at baseline, baseline post-application, week 2, and week 4...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28402099/decreasing-the-wettability-of-cellulose-nanocrystal-surfaces-using-wrinkle-based-alignment
#17
Ragesh Prathapan, Joseph D Berry, Andreas Fery, Gil Garnier, Rico F Tabor
Cellulose nanocrystals (CNCs) are a particularly appealing format of the natural biopolymer due to their exceptional strength, nanoscale dimensions and needle-like shape anisotropy. However, CNCs are hydrophilic and hence their wettability makes them impractical for many coating applications, with various approaches using chemical functionalization to overcome this. Here we show that CNC-coated surfaces can be rendered hydrophobic by alignment of the native CNCs using a wrinkled template-mediated printing process...
April 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28401287/graphene-oxide-for-solid-phase-extraction-of-bioactive-phenolic-acids
#18
Xiudan Hou, Xusheng Wang, Yingxin Sun, Licheng Wang, Yong Guo
A solid-phase extraction (SPE) method for the efficient analysis of trace phenolic acids (PAs, caffeic acid, ferulic acid, protocatechuic acid, cinnamic acid) in urine was established. In this work, a graphene oxide (GO) coating was grafted onto pure silica to be investigated as SPE material. The prepared GO surface had a layered and wrinkled structure that was rough and well organized, which could provide more open adsorption sites. Owing to its hydrophilicity and polarity, GO showed higher extraction efficiency toward PAs than reduced GO did, in agreement with the theoretical calculation results performed by Gaussian 09 software...
April 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28397935/beyond-buckling-humidity-independent-measurement-of-the-mechanical-properties-of-green-nanobiocomposite-films
#19
Urooj Gill, Travis Sutherland, Sebastian Himbert, Yujie Zhu, Maikel C Rheinstädter, Emily D Cranston, Jose M Moran-Mirabal
Precise knowledge of the mechanical properties of emerging nanomaterials and nanocomposites is crucial to match their performance with suitable applications. While methods to characterize mechanical properties exist, they are limited by instrument sensitivity and sample requirements. For bio-based nanomaterials this challenge is exacerbated by the extreme dependence of mechanical properties on humidity. This work presents an alternative approach, based on polymer shrinking-induced wrinkling mechanics, to determine the elastic modulus of nanobiocomposite films in a humidity-independent manner...
April 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28397901/the-role-of-ligands-in-the-mechanical-properties-of-langmuir-nanoparticle-films
#20
Sean D Griesemer, Siheng Sean You, Pongsakorn Kanjanaboos, Melanie Calabro, Heinrich M Jaeger, Stuart A Rice, Binhua Lin
Langmuir monolayers of ligand-capped inorganic nanoparticles exhibit rich morphologies under lateral compression such as wrinkling, folding, and multilayer nucleation. We demonstrate that the ligands play a crucial role in the mechanical properties of nanoparticle films by probing the morphology and anisotropic stress response during lateral compression of films with systematically varied ligand concentrations. Increasing the ligand concentration of the films past a threshold value inhibits monolayer wrinkling and folding in favor of multilayer formation, and sharply reduces the compressive and shear moduli...
April 11, 2017: Soft Matter
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