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https://www.readbyqxmd.com/read/28923767/shrinkage-of-spray-freeze-dried-microparticles-of-pure-protein-for-ballistic-injection-by-manipulation-of-freeze-drying-cycle
#1
Georg Straller, Geoffrey Lee
Spray-freeze-drying was used to produce shrivelled, partially-collapsed microparticles of pure proteins that may be suitable for use in a ballistic injector. Various modifications of the freeze drying cycle were examined for their effects on collapse of the pure protein microparticles. The use of annealing at a shelf temperature of up to +10°C resulted in no visible particle shrinkage. This was because of the high Tg' of the pure protein. Inclusion of trehalose or sucrose led to particle shrinkage because of the plasticizing effects of the disaccharides on the protein...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28915279/first-consensus-on-primary-prevention-and-early-intervention-in-aesthetic-medicine
#2
Marina Landau, Chytra V Anand, Thierry Besins, Yates Yen Yu Chao, Sabrina Guillen Fabi, Uliana Gout, Martina Kerscher, Tatjana Pavicic, Peter Hsien Li Peng, Berthold Rzany, Gerhard Sattler, Tunk Tiryaki, Heidi A Waldorf, Andre Braz
BACKGROUND: Facial aging is a complex interplay of extrinsic and intrinsic factors leading to progressive changes in the skin, subcutaneous tissue, and bone. Clinical experience suggests that early aesthetic intervention may slow the signs of aging, but treatment in the absence of symptoms or with minimal signs of aging has not yet been properly addressed. OBJECTIVES: To provide treatment recommendations for primary prevention and early intervention in individuals with no or minimal signs of aging...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28913927/the-efficacy-and-safety-of-a-monophasic-hyaluronic-acid-filler-in-the-correction-of-nasolabial-folds-a-randomized-multicenter-single-blinded-split-face-study
#3
Hyun Jung Kwon, Eun Jung Ko, Sun Young Choi, Eun Ja Choi, Yu-Jin Jang, Beom Joon Kim, Yang Won Lee
BACKGROUND: The different rheological properties of hyaluronic acid (HA) filler reflect their specific manufacturing processes and resultant physicochemical characteristics. However, there are few researches about the relationship between product differences and clinical outcome when HA fillers are used for nasolabial folds (NLFs). AIMS: This study sought to compare the rheological properties, efficacy and safety of a monophasic HA filler, and a well-studied biphasic HA filler, in the treatment of NLFs...
September 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28911889/-benefits-of-volumetric-to-facial-rejuvenation-part-2-dermal-fillers
#4
P Bui, A Pons Guiraud, C Lepage
Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Approaches and injection methods are the same for all fillers, corresponding to those for autologous fat injection, the reference substance, with a few particularities...
September 11, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28906254/a-synoptic-review-of-caryophyllaeus-gmelin-1790-cestoda-caryophyllidea-parasites-of-cyprinid-fishes
#5
Daniel Barcak, Mikulas Oros, Vladimira Hanzelova, Tomas Scholz
Tapeworms of the genus Caryophyllaeus Gmelin, 1790 (Caryophyllidea: Caryophyllaeidae), common parasites of cyprinid fishes, are reviewed and taxonomic status of 42 nominal taxa that have been placed in the genus during its long history is clarified. The following seven species occurring in the Palaearctic Region are recognised as valid: C. laticeps (Pallas, 1781), C. auriculatus (Kulakovskaya, 1961), C. balticus (Szidat, 1941) comb. n. (syn. Khawia baltica Szidat, 1941), C. brachycollis Janiszewska, 1953, C...
August 16, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28902221/two-field-surface-pattern-control-via-marginally-stable-magnetorheological-elastomers
#6
Erato Psarra, Laurence Bodelot, Kostas Danas
The stability and post-bifurcation of a non-linear magnetoelastic film/substrate block is experimentally exploited to obtain active control of surface roughness. The non-intuitive interplay between magnetic field and elastic deformation owes to material and geometry selection, namely a ferromagnetic particle composite film bonded on a compliant passive foundation. Cooperation of the two otherwise independent loading mechanisms-mechanical pre-compression and magnetic field-allows one to bring the structure near a marginally stable state and then destabilize it with either magnetic or mechanical fields...
September 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/28902030/multimodal-approach-for-treating-horizontal-neck-wrinkles-using-intensity-focused-ultrasound-cohesive-polydensified-matrix-hyaluronic-acid-and-incobotulinumtoxina
#7
Heedae Jeon, Taeyoon Kim, Heesu Kim, Sung Bin Cho
BACKGROUND: For the restoration of horizontal neck wrinkles, multimodal approaches using neuromodulators, intensity focused ultrasound (IFU), and fine line fillers are recommended. OBJECTIVE: To evaluate the efficacy and safety of a 1-day, multimodal approach for horizontal neck wrinkles. METHODS: Twelve female patients with horizontal neck wrinkles were treated with a combined treatment of IFU, cohesive polydensified matrix hyaluronic acid (CPMHA), and incobotulinumtoxinA...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28900534/resveratrol-enriched-rice-attenuates-uvb-ros-induced-skin-aging-via-downregulation-of-inflammatory-cascades
#8
Lalita Subedi, Taek Hwan Lee, Hussain Mustatab Wahedi, So-Hyeon Baek, Sun Yeou Kim
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28895754/coenzyme-q10-and-retinaldehyde-co-loaded-nanostructured-lipid-carriers-for-efficacy-evaluation-in-wrinkles
#9
Kritika Nayak, Sameer S Katiyar, Varun Kushwah, Sanyog Jain
The present study depicts coenzyme Q10 (CoQ10) and retinaldehyde (RAL) co-loaded Nanostructured Lipid Carriers (NLCs); having activity on different targets of photoageing, which can overcome deficits of conventional topical dosage forms. The developed NLCs were characterized for particle size, polydispersity index, and % Entrapment efficiency, followed by their incorporation into Carbopol® 934P-NF gel. In vitro cellular uptake and cytotoxicity assay was performed to evaluate NLCs and in vivo study on UV induced wrinkle model to determine efficacy of NLCs...
September 12, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28894863/circular-torsion-induced-fan-blade-shaped-wrinkling-in-two-dimensional-nano-rings
#10
Hongwei Bao, Yuhong Huang, Zhi Yang, Yaping Miao, Yunjin Sun, Yu Bai, Kewei Xu, Fei Ma
Molecular dynamics (MD) simulations are conducted to study the deformation behavior and strain distribution in two-dimensional (2D) nano-rings of graphene, single-layer black phosphorus (SLBP) and single-layer MoS2 (SLMoS2) under circular torsion. Interestingly, fan-blade shaped wrinkling is generated, in which the maximum torsion angle (Δθ) and the potential energy change per atom (ΔPe) increase with increasing inner radius but decrease with increasing temperature. As the inner radius is increased, the wave number of wrinkling increases but the wave amplitude decreases...
September 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28894510/antioxidant-and-anti-inflammatory-effects-of-shungite-against-ultraviolet-b-irradiation-induced-skin-damage-in-hairless-mice
#11
Ma Easter Joy Sajo, Cheol-Su Kim, Soo-Ki Kim, Kwang Yong Shim, Tae-Young Kang, Kyu-Jae Lee
As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm(2) for two consecutive days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28892233/hyaluronic-acid-microneedle-patch-for-the-improvement-of-crow-s-feet-wrinkles
#12
Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28892207/topological-design-of-ultrastrong-and-highly-conductive-graphene-films
#13
Yeye Wen, Mingmao Wu, Miao Zhang, Chun Li, Gaoquan Shi
Nacre-like graphene films are prepared by evaporation-induced assembly of graphene oxide dispersions containing small amounts of cellulose nanocrystal (CNC), followed by chemical reduction with hydroiodic acid. CNC induces the formation of wrinkles on graphene sheets, greatly enhancing the mechanical properties of the resultant graphene films. The graphene films deliver an ultrahigh tensile strength of 765 ± 43 MPa (up to 800 MPa in some cases), a large failure strain of 6.22 ± 0.19%, and a superior toughness of 15...
September 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#14
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28887842/seasonally-induced-alterations-of-some-facial-signs-in-caucasian-women-impact-of-a-daily-application-of-a-photo-protective-product
#15
Frederic Flament, Brigitte Gautier, Amelie-Marie Benize, Aude Charbonneau, Matthieu Cassier
OBJECTIVES: These were two-fold: i) to record through standardized pictures, the possible changes in 14 facial signs induced, in a 6-month period, by the periodical shift from winter to summer in a group of 42 Caucasian women residing in Paris and ii) to appraise the preventive effects of a strong photo-protective product, daily applied to their face by an additional group (N=40) of women of same age-range and presenting same severities of facial signs in winter. METHODS: Facial signs (structural and pigmentation-related) were graded in blind by a panel of 12 experts from photographs taken under standard conditions...
September 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28884442/whitening-and-anti-wrinkle-activities-of-ferulic-acid-isolated-from-tetragonia-tetragonioides-in-b16f10-melanoma-and-ccd-986sk-fibroblast-cells
#16
Hye-Jin Park, Jun-Hyo Cho, Shin-Hyub Hong, Dong-Hee Kim, Hee-Young Jung, In-Kyu Kang, Young-Je Cho
Ferulic acid isolated from Tetragonia tetragonioides was tested for its whitening effect on the B16F10 mouse melanoma cell line and its anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line. Ferulic acid, one of the primary phenolic compounds that can be isolated from T. tetragonioides, has been reported to show potential as a functional food, for its whitening effect and anti-wrinkle activity. To measure its whitening and anti-wrinkle activities, cells were treated with ferulic acid isolated from T...
September 7, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28883505/channel-formation-and-membrane-deformation-via-sterol-aided-polymorphism-of-amphidinol-3
#17
Masayuki Iwamoto, Ayumi Sumino, Eri Shimada, Masanao Kinoshita, Nobuaki Matsumori, Shigetoshi Oiki
Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in the membrane leaflet of the AM3-added side. The variable conductance suggests the formation of a multimeric barrel-stave pore. At high AM3 concentrations, giant-conductance "jumbo" channels (~40 nS) emerged...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881225/the-oxidative-stress-response-of-oxytetracycline-in-the-ciliate-pseudocohnilembus-persalinus
#18
Chongnv Wang, Xuming Pan, Yawen Fan, Ying Chen, Weijie Mu
Oxytetracycline (OTC) is commonly employed in fish farms to prevent bacterial infections in China, and because of their widely and intensive use, the potential harmful effects on organisms in aquatic environment are of great concern. Ciliates play an important role in aquatic food webs as secondary producers, and Pseudocohnilembus persalinus, is one kind of them which are easily found in fish farms, surviving in polluted water. Therefore, using P. persalinus as experimental models, this study investigated the effects of oxytetracycline (OTC) on the growth, antioxidant system and morphological damage in pollution-resistant ciliates species...
August 24, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28877151/youtube-videos-on-botulinum-toxin-a-for-wrinkles-a-useful-resource-for-patient-education
#19
Katharine Wong, Judy Doong, Trinh Trang, Sarah Joo, Anna L Chien
BACKGROUND: Patients interested in botulinum toxin type A (BTX-A) for wrinkles search for videos on YouTube, but little is known about the quality and reliability of the content. OBJECTIVE: The authors examined the quality, reliability, content, and target audience of YouTube videos on BTX for wrinkles. MATERIALS AND METHODS: In this cross-sectional study, the term "Botox" was searched on YouTube. Sixty relevant videos in English were independently categorized by 2 reviewers as useful informational, misleading informational, useful patient view, or misleading patient view...
September 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28872816/superhydrophilic-wrinkle-free-cotton-fabrics-via-plasma-and-nanofluid-treatment
#20
Lihong Lao, Liling Fu, Genggeng Qi, Emmanuel P Giannelis, Jintu Fan
We demonstrate in this study, a wrinkle-free, superhydrophilic cotton fabric (contact angle ~ 0o) by uniformly attaching specially engineered nanoparticles to plasma pre-treated cotton fabric. Because of their highly charged nature, the nanoparticles are firmly anchored on the fabric via electrostatic interactions, as confirmed by microscopy and chemical analyses. The durability of wetting behavior and wrinkle-free property of the nanoparticle-coated fabrics was evaluated via aging, laundering and abrasion tests...
September 5, 2017: ACS Applied Materials & Interfaces
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