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https://www.readbyqxmd.com/read/28088375/two-stage-management-of-cierny-mader-type-iv-chronic-osteomyelitis-of-the-long-bones
#1
Hongri Wu, Jie Shen, Xin Yu, Jingshu Fu, Shengpeng Yu, Dong Sun, Zhao Xie
INTRODUCTION: Cierny-Mader (C-M) type IV chronic osteomyelitis represents a complex clinical challenge with permeation of extensive bone and soft tissue involvement. Aggressive debridement through viable tissue margin includes en bloc resection improves the odds of eradication of infection, which creates large bone and soft tissue loss in treating this type of osteomyelitis. The potentially large defects increase reconstruction problems with traditional reconstruction technique. The newly staged induced membrane technique presents length-independent, potential as an alternative reconstruction method for segmental bone defects due to type IV chronic osteomyelitis...
January 6, 2017: Injury
https://www.readbyqxmd.com/read/28081443/the-bacterial-t6ss-effector-evpp-prevents-nlrp3-inflammasome-activation-by-inhibiting-the-ca-2-dependent-mapk-jnk-pathway
#2
Hao Chen, Dahai Yang, Fajun Han, Jinchao Tan, Lingzhi Zhang, Jingfan Xiao, Yuanxing Zhang, Qin Liu
Inflammasome activation is an important innate immune defense mechanism against bacterial infection, and in return, bacteria express virulence determinants that counteract inflammasome activation. Many such effectors are secreted into host cells via specialized bacterial secretion systems. Here, the intracellular pathogenic bacterium Edwardsiella tarda was demonstrated to activate NLRC4 and NLRP3 inflammasomes via a type III secretion system (T3SS), and to inhibit NLRP3 inflammasome via a type VI secretion system (T6SS), indicating the antagonistic roles of these systems in inflammasome signaling...
January 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28080221/molecular-mechanisms-of-antisense-oligonucleotides
#3
Stanley T Crooke
In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems. Since 1989, my research has focused primarily on this topic, although I have been involved in most areas of research in antisense technology. I believe that the art of excellent science is to frame large important questions that are perhaps not immediately answerable with existing knowledge and methods, and then conceive a long-term (multiyear) research strategy that begins by answering the most pressing answerable questions on the path to the long-term goals...
January 12, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28078920/do-predictors-of-return-to-work-and-recurrence-of-work-disability-due-to-mental-disorders-vary-by-age-a-cohort-study
#4
Pauliina Mattila-Holappa, Jenni Ervasti, Matti Joensuu, Kirsi Ahola, Jaana Pentti, Tuula Oksanen, Jussi Vahtera, Mika KivimÄki, Marianna Virtanen
BACKGROUND: The extent to which predictors of return to work (RTW) and recurrence of work disability episodes vary by age group is not well understood. METHODS: We examined the associations of sociodemographic and clinical factors with RTW and recurrence after mental-disorder-related work disability episodes in a cohort of 10,496 Finnish public sector employees. Disability records were derived from national disability registers between 2005 and 2011. Effect modification by age was examined in age groups of 21-34, 35-50 and >50 years...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28078789/-breastfeeding-without-baby-a-longitudinal-qualitative-investigation-of-how-mothers-perceive-feel-about-and-practice-human-milk-expression
#5
Julia P Felice, Sheela R Geraghty, Caroline W Quaglieri, Rei Yamada, Adriana J Wong, Kathleen M Rasmussen
Most American mothers who produce human milk (HM) now pump in place of some or all feeding at the breast, and most American infants are now fed pumped HM. We aimed to investigate mothers' perceptions of, attitudes toward, and practices for pumping and providing pumped HM. Results related to pumping are reported here. We conducted in-depth, semi-structured interviews among a diverse sample of 20 mothers who pumped, following each from pregnancy through infant HM-feeding cessation up to 1 year postpartum. Data were analyzed using thematic analysis with Atlas...
January 12, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28077845/when-words-were-wanted-but-woefully-wanting-we-waged-war-with-chess
#6
Burton Norman Seitler
What do you say to a child who rarely speaks? How do you work with such a youngster? What are the sine qua nons or guiding principles upon which analysts can draw? And, how do we know if we are being helpful? Sam was 9-years when I began treating him. He was extremely withdrawn and rarely spoke more than a few words. Instead, he mainly played chess. I did not know at first whether Sam's taciturn demeanor was due to shyness, limited verbal abilities, or the stultifying effects of trauma. Fortuitously, during one of many seemingly "innocent" games of chess, Sam happened to make a bold move, to which I admiringly remarked, "What a move, you're killing me...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28077577/extracellular-microrna-signature-of-human-helper-t-cell-subsets-in-health-and-autoimmunity
#7
Anna Torri, Donatella Carpi, Elisabetta Bulgheroni, Maria-Cristina Crosti, Monica Moro, Paola Gruarin, Riccardo L Rossi, Grazisa Rossetti, Dolores Di Vizio, Mirjam Hoxha, Valentina Bollati, Cristina Gagliani, Carlo Tacchetti, Moira Paroni, Jens Geginat, Laura Corti, Luigia Venegoni, Emilio Berti, Massimiliano Pagani, Giuseppe Matarese, Sergio Abrignani, Paola de Candia
Upon TCR stimulation, CD4+ T lymphocytes release extracellular vesicles (EVs) containing microRNAs. However, no data are available on whether human CD4+ T cell subsets release EVs containing different pattern of microRNAs. The present work aimed at filling this gap by assessing the microRNA content in EVs released upon in vitro TCR stimulation of Th1, Th17 and T regulatory (Treg) cells. Our results indicate that EVs released by Treg cells are significantly different compared to those released by the other subsets...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28075090/carpal-tunnel-syndrome-diagnosis-and-management
#8
Jennifer Wipperman, Kyle Goerl
Carpal tunnel syndrome, the most common entrapment neuropathy of the upper extremity, is caused by compression of the median nerve as it travels through the carpal tunnel. Classically, patients with the condition experience pain and paresthesias in the distribution of the median nerve, which includes the palmar aspect of the thumb, index and middle fingers, and radial half of the ring finger. Additional clues include positive physical examination findings, such as the flick sign, Phalen maneuver, and median nerve compression test...
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28073345/reasons-for-faculty-departures-from-an-academic-medical-center-a-survey-and-comparison-across-faculty-lines
#9
Sabine C Girod, Magali Fassiotto, Roseanne Menorca, Henry Etzkowitz, Sherry M Wren
BACKGROUND: Faculty departure can present significant intellectual costs to an institution. The authors sought to identify the reasons for clinical and non-clinical faculty departures at one academic medical center (AMC). METHOD: In May and June 2010, the authors surveyed 137 faculty members who left a west coast School of Medicine (SOM) between 1999 and 2009. In May and June 2015, the same survey was sent to 40 faculty members who left the SOM between 2010-2014, for a total sample size of 177 former faculty members...
January 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28072795/treatment-outcomes-for-patients-with-failed-back-surgery
#10
Jae Hwan Cho, Jae Hyup Lee, Kwang Sup Song, Jae-Young Hong, Yoon-Suk Joo, Dong-Ho Lee, Chang Ju Hwang, Choon Sung Lee
BACKGROUND: Failed back surgery syndrome (FBSS) is a frequently encountered disease entity following lumbar spinal surgery. Although many plausible reasons have been investigated, the exact pathophysiology remains unknown. Various medications, reoperations, interventions such as spinal cord stimulation, epidural adhesiolysis or epidural injection, exercise therapy, and psychotherapy have been suggested treatment options. However, the evidence of the clinical outcome for each treatment has not been clearly determined...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28068478/dupuytren-s-contracture
#11
Ann R Lurati
Dupuytren's disorder is considered a genetic disorder and therefore not covered under workers' compensation. Personal risk factors include workers of Northern European descent and workers that are older than 50 years. However, new evidence has shown that certain occupational activities may increase the risk of developing this disorder. This article is a review of the literature with a case study. Work-related and personal risk factors are explored, as well as interventions and return to work recommendations...
January 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28067941/preliminary-considerations-about-the-presence-of-aedes-albopictus-skuse-1897-diptera-culicidae-during-winter-in-the-northwestern-italy
#12
M Dutto, A Mosca
Aedes albopictus, the Asian tiger mosquito, was unintentionally introduced in Italy at the beginning of the 1990s. In few decades it spread almost in the whole Country. In Piedmont, the first report dates back to 1994. Usually, temperate populations are affected by seasonal temperature and photoperiodicity and can overwinter by producing eggs that undergo a winter diapause. In Rome females of the species extended their trophic activity to the coldest months of the year, but there is no notice about a similar behaviour for northern areas of the Country...
January 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28067458/addressing-barriers-to-health-experiences-of-breastfeeding-mothers-after-returning-to-work
#13
Sousan Valizadeh, Mina Hosseinzadeh, Eesa Mohammadi, Hadi Hassankhani, Marjaneh M Fooladi, Virginia Schmied
Breastfeeding mothers returning to work often feel exhausted as they must feed on demand and attend to family and employment responsibilities, leading to concerns for their personal health. This study was prompted by a desire to understand and identify barriers to mothers' health. We describe the experiences of 12 Iranian breastfeeding and employed mothers through in-depth and semi-structured interviews and thematic analysis. Two main themes emerged: (i) working and mothering alone and (ii) facing concerns about health...
January 9, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/28066693/society-of-pediatric-psychology-workforce-survey-development-of-survey-methods-sample-characteristics-and-lessons-learned
#14
Tim Wysocki, Cheryl L Brosig, Marisa E Hilliard
There are few detailed workforce studies of specialty fields within professional psychology, and none have been reported for pediatric psychology since 2006. Availability of such data could facilitate more-informed decision making by students and trainees, psychologists pursuing employment opportunities, and psychologists involved in employment or compensation negotiations. This article describes the work of a task force of the American Psychological Association (APA) Division 54 (Society of Pediatric Psychology) in the design, construction, pretesting, distribution, and data management for the Society of Pediatric Psychology (SPP) Workforce Survey...
March 2016: Clinical Practice in Pediatric Psychology
https://www.readbyqxmd.com/read/28065952/harassment-of-working-women-in-the-public-health-sector-of-abbottabad-in-socio-legal-perspective
#15
Musarrat Jabeen, Zeeshan Muhammad Naeem, Muhammad Umar, Muhammad Arfat Yameen, Saira Azhar
OBJECTIVE: To investigate the efficacy and impact of Protection Against Harassment of Women at Workplace Act 2010 in the public health sector in its socio-legal perspective. METHODS: This cross-sectional study was conducted from July to December 2014 in Abbottabad, Pakistan, and comprised subjects selected from 53 basic health units managed by the government. SPSS 20 was used for statistical analysis. RESULTS: Of the 450 questionnaires, 430(96...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28065405/fingertip-reconstruction-with-a-posterior-interosseous-artery-perforator-flap-a-minimally-invasive-procedure-for-donor-and-recipient-sites
#16
Satoshi Usami, Mutsumi Okazaki
BACKGROUND: A posterior interosseous artery perforator flap is used for small defects and leaves no functional disturbance at the flap donor site. This report aimed to describe our experience with the transfer of this flap for fingertip defects and the evaluation of postoperative function. METHODS: In total, 11 flaps were used for 13 fingertip reconstructions in 11 patients. Two patients had two finger defects simultaneously covered with one bridge flap, and five flaps were harvested in true perforator flap style...
December 14, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28063909/periprocedural-outcomes-comparing-fibroid-embolization-and-focused-ultrasound-a-randomized-controlled-trial-and-comprehensive-cohort-analysis
#17
Emily P Barnard, Ahmed M AbdElmagied, Lisa E Vaughan, Amy L Weaver, Shannon K Laughlin-Tommaso, Gina K Hesley, David A Woodrum, Vanessa L Jacoby, Maureen P Kohi, Thomas M Price, Angel Nieves, Michael J Miller, Bijan J Borah, Krzysztof R Gorny, Phyllis C Leppert, Lisa G Peterson, Elizabeth A Stewart
BACKGROUND: Uterine fibroids are a common problem for reproductive-aged women, yet little comparative effectiveness research is available to guide treatment choice. Uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surgery are minimally invasive therapies approved by the United States Food and Drug Administration for treating symptomatic uterine fibroids. The Fibroid Interventions: Reducing Symptoms Today and Tomorrow study is the first randomized controlled trial to compare these 2 fibroid treatments...
January 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28062091/effects-of-person-centred-care-on-health-outcomes-a-randomized-controlled-trial-in-patients-with-acute-coronary-syndrome
#18
Laura Pirhonen, Elisabeth Hansson Olofsson, Andreas Fors, Inger Ekman, Kristian Bolin
OBJECTIVES: To study the effects of person-centred care provided to patients with acute coronary syndrome, using four different health-related outcome measures. Also, to examine the performance of these outcomes when measuring person-centred care. DATA AND METHOD: The data used in this study consists of primary data from a multicentre randomized parallel group, controlled intervention study for patients with acute coronary syndrome at Sahlgrenska University Hospital in Gothenburg, Sweden...
December 13, 2016: Health Policy
https://www.readbyqxmd.com/read/28061870/referring-to-multimodal-rehabilitation-for-patients-with-musculoskeletal-disorders-a-register-study-in-primary-health-care
#19
Charlotte Post Sennehed, Sara Holmberg, Kjerstin Stigmar, Malin Forsbrand, Ingemar F Petersson, Anja Nyberg, Birgitta Grahn
BACKGROUND: In 2008, the Swedish government introduced a National Rehabilitation Program, in which the government financially reimburses the county councils for evidence-based multimodal rehabilitation (MMR) interventions. The target group is patients of working age with musculoskeletal disorders (MSD), expected to return to work or remain at work after rehabilitation. Much attention in the evaluations has been on patient outcomes and on processes. We lack knowledge about how factors related to health care providers and community can have an impact on how patients have access to MMR...
January 7, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28061740/prevalence-and-determinants-of-bullying-among-health-care-workers-in-portugal
#20
Pedro Norton, Viviana Costa, Joel Teixeira, Ana Azevedo, António Roma-Torres, Joana Amaro, Liliana Cunha
Bullying is defined as systematic exposure to humiliation as well as hostile and violent behaviors against one or more individuals. These behaviors are a serious, growing problem, which affects a significant proportion of health care professionals. To support the hospital's risk management policy, a cross-sectional study was undertaken to determine the prevalence of bullying in this institution and identify the determinants of bullying. Bullying was measured using the Negative Acts Questionnaire-Revised, Portuguese version (NAQ-R), a self-administered tool...
January 1, 2017: Workplace Health & Safety
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