keyword
MENU ▼
Read by QxMD icon Read
search

acquired brain injury

keyword
https://www.readbyqxmd.com/read/28641533/role-and-therapeutic-potential-of-astrocytes-in-amyotrophic-lateral-sclerosis
#1
Mariana Pehar, Benjamin A Harlan, Kelby M Killoy, Marcelo R Vargas
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. The molecular mechanism underlying the progressive degeneration of motor neuron remains uncertain but involves a non-cell autonomous process. In acute injury or degenerative diseases astrocytes adopt a reactive phenotype known as astrogliosis. Astrogliosis is a complex remodeling of astrocyte biology and most likely represents a continuum of potential phenotypes that affect neuronal function and survival in an injury-specific manner...
June 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28640114/injury-of-the-dentato-rubro-thalamic-tract-in-patients-with-cerebellar-infarct-case-report
#2
Sung Ho Jang, Hyeok Gyu Kwon
RATIONALE: Several studies using diffusion tensor tractography (DTT) have reported on injury in the dentato-rubro-thalamic tract (DRTT) in patients with brain injury. However, there is no study of injury in the DRTT following cerebellar infarct. We report on patients with injury in the DRTT following cerebellar infarct, demonstrated on DTT. PATIENT CONCERNS: Three patients with cerebellar infarct were enrolled in this study. Diffusion tensor imaging data were acquired at 3 weeks (patient 1) and 2 weeks (patients 2 and 3) after onset and the DRTT was reconstructed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28631942/a-systematic-review-of-factors-affecting-driving-and-public-transportation-among-youth-and-young-adults-with-acquired-brain-injury
#3
Sally Lindsay, Andrei Stoica
PURPOSE: Although many people with an acquired brain injury (ABI) encounter difficulties with executive functioning and memory which could negatively affect driving, few people are assessed for fitness to drive after injury. The purpose of this systematic review was to synthesize the literature on factors affecting driving and public transportation among youth and young adults with ABI, post injury. METHOD: Seven databases were systematically searched for articles from 1980 to 2016...
June 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28627942/diffusion-imaging-of-mild-traumatic-brain-injury-in-the-impact-accelerated-rodent-model-a-pilot-study
#4
Zora Kikinis, Marc Muehlmann, Ofer Pasternak, Sharon Peled, Praveen Kulkarni, Craig Ferris, Sylvain Bouix, Yogesh Rathi, Inga K Koerte, Steve Pieper, Alexander Yarmarkovich, Caryn L Porter, Bruce S Kristal, Martha E Shenton
PRIMARY OBJECTIVE: There is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent model. This study aims to investigate the processes occurring 1 week after injury at the time of regeneration and degeneration using diffusion tensor imaging (DTI) in the impact acceleration rat mTBI model. RESEARCH DESIGN: Eighteen rats were subjected to impact acceleration injury, and three rats served as sham controls...
June 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28620341/the-intersection-between-ocular-and-manual-motor-control-eye-hand-coordination-in-acquired-brain-injury
#5
REVIEW
John-Ross Rizzo, Maryam Hosseini, Eric A Wong, Wayne E Mackey, James K Fung, Edmond Ahdoot, Janet C Rucker, Preeti Raghavan, Michael S Landy, Todd E Hudson
Acute and chronic disease processes that lead to cerebral injury can often be clinically challenging diagnostically, prognostically, and therapeutically. Neurodegenerative processes are one such elusive diagnostic group, given their often diffuse and indolent nature, creating difficulties in pinpointing specific structural abnormalities that relate to functional limitations. A number of studies in recent years have focused on eye-hand coordination (EHC) in the setting of acquired brain injury (ABI), highlighting the important set of interconnected functions of the eye and hand and their relevance in neurological conditions...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28606421/spontaneous-jaw-muscle-activity-in-patients-with-acquired-brain-injuries-preliminary-findings
#6
Mohit Kothari, Vibeke Louise Funch Madsen, Eduardo E Castrillon, Jørgen Feldbæk Nielsen, Peter Svensson
PATIENTS: High or excessive parafunctional jaw muscle activity is a frequent complication of acquired brain injury (ABI) and may have some similarities to bruxism. Bruxism has been associated with increased tooth wear, masseter hypertrophy and headaches. The aim of this observational study was to identify the levels of jaw muscle activity from fourteen ABI patients having different functional and cognitive levels in their early phase of neurological rehabilitation (according to their Ranchos Los Amigos Scale (RLAS) score)...
June 9, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#7
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
https://www.readbyqxmd.com/read/28602116/rehabilitation-goal-setting-with-community-dwelling-adults-with-acquired-brain-injury-a-theoretical-framework-derived-from-clinicians-reflections-on-practice
#8
Sarah Prescott, Jennifer Fleming, Emmah Doig
PURPOSE: The aim of this study was to explore clinicians' experiences of implementing goal setting with community dwelling clients with acquired brain injury, to develop a goal setting practice framework. METHOD: Grounded theory methodology was employed. Clinicians, representing six disciplines across seven services, were recruited and interviewed until theoretical saturation was achieved. A total of 22 clinicians were interviewed. RESULTS: A theoretical framework was developed to explain how clinicians support clients to actively engage in goal setting in routine practice...
June 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28599608/a-brain-electrical-activity-eeg-based-biomarker-of-functional-impairment-in-traumatic-head-injury-a-multisite-validation-trial
#9
Daniel Hanley, Leslie S Prichep, Neeraj Badjatia, Jeff Bazarian, RIchard P Chiacchierini, Kenneth C Curley, John S Garrett, Elizabeth B Jones, Rosanne Naunheim, Brian J O'Neil, John O'Neill, Wright David, J Stephen Huff
The potential clinical utility of a novel quantitative EEG-based Brain Function Index (BFI) as a measure of the presence and severity of functional brain injury was studied as part of an independent prospective validation trial. The BFI was derived using EEG features associated with functional brain impairment reflecting current consensus on the physiology of concussive injury. 720 adult patients (18-85 years) evaluated within 72 hours of sustaining a closed head injury were enrolled at 11 US Emergency Departments...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28596753/auditory-processing-after-early-left-hemisphere-injury-a-case-report
#10
Cristina Ferraz Borges Murphy, Georgios Stavrinos, Kling Chong, Tony Sirimanna, Doris-Eva Bamiou
Few studies have addressed the long-term outcomes of early brain injury, especially after hemorrhagic stroke. This is the first study to report a case of acquired auditory processing disorder in a 10-year-old child who had a severe left hemorrhagic cerebral infarction at 13 months of age, compromising nearly all of the left temporal lobe. This case, therefore, is an excellent and rare opportunity to investigate the presence of neural plasticity of central auditory system in a developing brain followed severe brain damage...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28588534/cognitive-effects-of-thinkrx-cognitive-rehabilitation-training-for-eleven-soldiers-with-brain-injury-a-retrospective-chart-review
#11
Christina Ledbetter, Amy Lawson Moore, Tanya Mitchell
Cognitive rehabilitation training is a promising technique for remediating the cognitive deficits associated with brain injury. Extant research is dominated by computer-based interventions with varied results. Results from clinician-delivered cognitive rehabilitation are notably lacking in the literature. The current study examined the cognitive outcomes following ThinkRx, a clinician-delivered cognitive rehabilitation training program for soldiers recovering from traumatic brain injury and acquired brain injury...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28587899/anticonvulsant-effect-of-flupirtine-in-an-animal-model-of-neonatal-hypoxic-ischemic-encephalopathy
#12
Dayalan Sampath, Robert Valdez, Andrew M White, Yogendra H Raol
Research studies suggest that neonatal seizures, which are most commonly associated with hypoxic-ischemic injury, may contribute to brain injury and adverse neurologic outcome. Unfortunately, neonatal seizures are often resistant to treatment with current anticonvulsants. In the present study, we evaluated the efficacy of flupirtine, administered at clinically relevant time-points, for the treatment of neonatal seizures in an animal model of hypoxic-ischemic injury that closely replicates features of the human syndrome...
June 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28578113/safety-of-percutaneous-dilatational-tracheostomy-in-patients-with-acute-brain-injury-and-a-reduced-pao2-fio2-ratio-a-retrospective-analysis-of-54-patients
#13
Claudia Ditz, Jann F Wojak, Emma Smith, Abdulkareem Abusamha, Volker M Tronnier, Jan Gliemroth, Jan N Kuechler
OBJECTIVE: Percutaneous Dilatational Tracheostomy (PDT) is a commonly performed method in neurocritical care, whose safety has been proven in numerous studies. Nevertheless, there are poor data regarding the application in patients with acute brain injury and poor respiratory function. The purpose of this study was to evaluate the incidence of hypoxemia and hypercapnia during PDT in those patients. METHODS: In a retrospective analysis, we acquired data from 54 patients with an acute brain injury (ABI) and a reduced PaO2/FiO2 ratio (PaO2/FiO2<300mmHg)...
May 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28575153/targeting-oxidative-stress-improves-disease-outcomes-in-a-rat-model-of-acquired-epilepsy
#14
Alberto Pauletti, Gaetano Terrone, Tawfeeq Shekh-Ahmad, Alessia Salamone, Teresa Ravizza, Massimo Rizzi, Anna Pastore, Rosaria Pascente, Li-Ping Liang, Bianca R Villa, Silvia Balosso, Andrey Y Abramov, Erwin A van Vliet, Ennio Del Giudice, Eleonora Aronica, Daniel J Antoine, Manisha Patel, Matthew C Walker, Annamaria Vezzani
Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than the disease and are ineffective in up to 30% of patients. There are no treatments for modifying the disease-preventing seizure onset, reducing severity or improving prognosis. Among the potential molecular targets for attaining these unmet therapeutic needs, we focused on oxidative stress since it is a pathophysiological process commonly occurring in experimental epileptogenesis and observed in human epilepsy. Using a rat model of acquired epilepsy induced by electrical status epilepticus, we show that oxidative stress occurs in both neurons and astrocytes during epileptogenesis, as assessed by measuring biochemical and histological markers...
May 30, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28573825/clinimetric-properties-of-the-nociception-coma-scale-revised-a-systematic-review
#15
REVIEW
P Vink, C Lucas, J M Maaskant, W S van Erp, R Lindeboom, H Vermeulen
The Nociception Coma Scale is a nociception behaviour observation tool, developed specifically for patients with disorders of consciousness (DOC) due to (acquired) brain injury. Over the years, the clinimetric properties of the NCS and its revised version (NCS-R) have been assessed, but no formal summary of these properties has been made. Therefore, we performed a systematic review on the clinimetric properties (i.e. reliability, validity, responsiveness and interpretability) of the NCS(-R). We systematically searched CENTRAL, CINAHL, Embase, PsycInfo and Web of Science until August 2015...
June 2, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28562164/exploring-the-feasibility-and-usability-of-the-experience-sampling-method-to-examine-the-daily-lives-of-patients-with-acquired-brain-injury
#16
Bert Lenaert, Max Colombi, Caroline van Heugten, Sascha Rasquin, Zuzana Kasanova, Rudolf Ponds
The experience sampling method (ESM) is a structured diary method with high ecological validity, in that it accurately captures the everyday context of individuals through repeated measurements in naturalistic environments. Our main objective was to investigate the feasibility of using ESM in individuals with acquired brain injury (ABI). A second goal was to explore the usability of ESM data on a clinical level, by illustrating the interactions between person, environment, and affect. The PsyMate device provided ABI patients (N = 17) with ten signals (beeps) per day during six consecutive days...
May 31, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28560156/neural-signature-of-coma-revealed-by-posteromedial-cortex-connection-density-analysis
#17
Briguita Malagurski, Patrice Péran, Benjamine Sarton, Beatrice Riu, Leslie Gonzalez, Fanny Vardon-Bounes, Thierry Seguin, Thomas Geeraerts, Olivier Fourcade, Francesco de Pasquale, Stein Silva
Posteromedial cortex (PMC) is a highly segregated and dynamic core, which appears to play a critical role in internally/externally directed cognitive processes, including conscious awareness. Nevertheless, neuroimaging studies on acquired disorders of consciousness, have traditionally explored PMC as a homogenous and indivisible structure. We suggest that a fine-grained description of intrinsic PMC topology during coma, could expand our understanding about how this cortical hub contributes to consciousness generation and maintain, and could permit the identification of specific markers related to brain injury mechanism and useful for neurological prognostication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28557478/assessment-of-emotion-processing-skills-in-acquired-brain-injury-using-an-ability-based-test-of-emotional-intelligence
#18
Sarah E Hall, Joanne M Wrench, Sarah J Wilson
Social and emotional problems are commonly reported after moderate to severe acquired brain injury (ABI) and pose a significant barrier to rehabilitation. However, progress in assessment of emotional skills has been limited by a lack of validated measurement approaches. This study represents the first formal psychometric evaluation of the use of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) V2.0 as a tool for assessing skills in perceiving, using, understanding and managing emotions following ABI...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28553237/a-longitudinal-study-of-relationships-between-identity-continuity-and-anxiety-following-brain-injury
#19
R S Walsh, Orla T Muldoon, Donal G Fortune, Stephen Gallagher
Objective: Anxiety is of particular importance following acquired brain injury (ABI), because anxiety has been identified as a significant predictor of functional outcomes. Continuity of self has been linked to post ABI adjustment and research has linked self-discrepancy to anxiety. This longitudinal study investigates the impact of affiliative and 'self as doer' self-categorisations anxiety. Materials and Methods: Data was collected at two time points. Fifty-three adult ABI survivors participating in post-acute community neuro-rehabilitation participated at time one and 32 of these participated at time two...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28543689/mild-cognitive-impairment-and-structural-brain-abnormalities-in-a-sexagenarian-with-a-history-of-childhood-traumatic-brain-injury
#20
John Darrell Van Horn, Andrei Irimia, Carinna M Torgerson, Avnish Bhattrai, Zachary Jacokes, Paul M Vespa
In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD)...
May 20, 2017: Journal of Neuroscience Research
keyword
keyword
31220
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"