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acquired brain injury

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https://www.readbyqxmd.com/read/28227510/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#1
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, An H Do, Zoran Nenadic, Colin M McCrimmon, Keulanna Gandasetiawan, Payam Heydari, Alireza Karimi-Bidhendi, Po T Wang, Charles Y Liu
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227095/a-small-portable-battery-powered-brain-computer-interface-system-for-motor-rehabilitation
#2
Colin M McCrimmon, Ming Wang, Lucas Silva Lopes, Po T Wang, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Colin M McCrimmon, Ming Wang, Lucas Silva Lopes, Po T Wang, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Ming Wang, An H Do, Zoran Nenadic, Colin M McCrimmon, Alireza Karimi-Bidhendi, Lucas Silva Lopes, Po T Wang, Charles Y Liu, Payam Heydari
Motor rehabilitation using brain-computer interface (BCI) systems may facilitate functional recovery in individuals after stroke or spinal cord injury. Nevertheless, these systems are typically ill-suited for widespread adoption due to their size, cost, and complexity. In this paper, a small, portable, and extremely cost-efficient (<;$200) BCI system has been developed using a custom electroencephalographic (EEG) amplifier array, and a commercial microcontroller and touchscreen. The system's performance was tested using a movement-related BCI task in 3 able-bodied subjects with minimal previous BCI experience...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222568/severe-disorders-of-consciousness-after-acquired-brain-injury-a-single-centre-long-term-follow-up-study
#3
Alex Lopez-Rolon
OBJECTIVES: To assess long-term clinical outcome, functional independence and health-related quality of life (HRQOL) in acquired brain injury (ABI) patients with a disorder of consciousness at admission to inpatient rehabilitation. METHODS: We selected patients from a cohort of ABI patients from a single centre. In addition to mortality, we measured level of consciousness with the Coma Remission Scale, functional independence with the Barthel Index, as well as generic and condition-specific HRQOL with the EQ5D and the "Quality of Life after Brain Injury" (QOLIBRI) respectively...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222544/inter-rater-reliability-of-the-chedoke-arm-and-hand-activity-inventory
#4
Denise Johnson, Jocelyn Harris, Paul Stratford, Julie Richardson
BACKGROUND: The Chedoke Arm and Hand Activity Inventory (CAHAI) is an assessment of upper limb function designed for use in the stroke population. The CAHAI has strong reliability and validity in this population; however, it is unknown whether this measure can be used with other clinical populations such as acquired brain injury (ABI). PURPOSE: The purpose of this study was to estimate the inter-rater reliability of the CAHAI when used with persons with ABI. METHODS: The research design was an observational parameter estimation study...
January 30, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28214960/axonal-disruption-in-white-matter-underlying-cortical-sulcus-tau-pathology-in-chronic-traumatic-encephalopathy
#5
Laurena Holleran, Joong Hee Kim, Mihika Gangolli, Thor Stein, Victor Alvarez, Ann McKee, David L Brody
Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-mortem CTE studies have also reported myelin loss, axonal injury and white matter degeneration. Currently, the diagnosis of CTE is restricted to post-mortem neuropathological analysis. We hypothesized that high spatial resolution advanced diffusion MRI might be useful for detecting white matter microstructural changes directly adjacent to gray matter tau pathology...
February 18, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28212177/neurocognitive-outcomes-for-acute-global-acquired-brain-injury-in-children
#6
Fenella J Kirkham
PURPOSE OF REVIEW: In children, acute global brain injury from traumatic brain injury (TBI) and nontraumatic coma has a substantial cost to the child, the family, and the society. There have historically been relatively few studies looking at long-term cognition and behavioural outcomes. RECENT FINDINGS: Long-term follow-up studies, population-based studies, and meta-analyses are now available for TBI in children as well as adults and suggest that there is a significant cognitive cost, particularly for processing speed, working memory, and intelligence quotient (IQ) in severe TBI...
February 15, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28211828/self-efficacy-and-quality-of-life-after-low-intensity-neuropsychological-rehabilitation-a-pre-post-intervention-study
#7
Ingrid Brands, Maud Custers, Caroline van Heugten
BACKGROUND: Being highly self-efficacious is a key factor in successful chronic disease self-management. It is unknown whether neuropsychological rehabilitation improves self-efficacy in managing the consequences of brain injury. OBJECTIVE: To investigate whether levels of general and brain injury specific self-efficacy and quality of life (QoL) increased after neuropsychological rehabilitation and whether cognitive performance was associated with self-efficacy...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211823/symptom-severity-and-life-satisfaction-in-brain-injury-the-mediating-role-of-disability-acceptance-and-social-self-efficacy
#8
Nicole Ditchman, Connie Sung, Amanda B Easton, Kristina S Johnson, Elisabeth Batchos
BACKGROUND: Although the negative impact of symptom severity on subjective well-being outcomes has been established among individuals with brain injury, the mediating and protective role that positive human traits might have on this relationship has not been adequately explored. OBJECTIVE: The purpose of this study was to examine the impact of social self-efficacy and disability acceptance on the relationship between symptom severity and life satisfaction among individuals with brain injury...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28209580/white-matter-tract-pathology-in-pediatric-anoxic-brain-injury-from-drowning
#9
M Ishaque, J H Manning, M D Woolsey, C G Franklin, F S Salinas, P T Fox
BACKGROUND AND PURPOSE: Although drowning is a leading cause of mortality and morbidity in young children, the neuropathologic consequences have not been fully determined. The purpose of this article was to quantitatively characterize white matter microstructural abnormalities in pediatric anoxic brain injury from nonfatal drowning and investigate the correlation with motor function. MATERIALS AND METHODS: Whole-brain T1-weighted and diffusion-weighted MR imaging datasets were acquired in 11 children with chronic anoxic brain injury and 11 age- and sex-matched neurotypical controls (4-12 years of age)...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28206800/perspectives-of-veterans-with-mild-traumatic-brain-injury-on-community-reintegration-making-sense-of-unplanned-separation-from-service
#10
Alexander V Libin, Manon Maitland Schladen, Ellen Danford, Samantha Cichon, Dwan Bruner, Joel Scholten, Maria Llorente, Slavomir Zapata, Alexander W Dromerick, Marc R Blackman, Kathryn M Magruder
For veterans separated from the military as a result of acquired mild traumatic brain injury (mTBI), the transition from a military identity to a civilian one is complicated by health, cognitive, and psychosocial factors. We conducted in-depth interviews with 8 veterans with mTBI to understand how they perceived the experience of departure from the military, rehabilitation services provided at a Department of Veterans Affairs (VA) Polytrauma Network Site, and reentry into civilian life. Two distinct patterns of thinking about community reintegration emerged...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28195961/bedside-ultrasound-to-facilitate-early-diagnosis-and-ease-of-follow-up-in-neurogenic-heterotopic-ossification-a-pilot-study-from-the-intensive-care-unit
#11
Konstantinos Stefanidis, Peter Brindley, Raymond Ramnarine, Michael Blaivas, Mohammad Daneshi, Paul S Sidhu, Abdoulrahman Alharthy, Dimitrios Karakitsos
OBJECTIVE: To explore the potential role of ultrasound (US) as a bedside tool in intensive care unit patients with presumed neurogenic heterotopic ossification (NHO). SETTING: Tertiary university teaching hospitals. PARTICIPANTS: Critical care patients with acquired brain injury. DESIGN: A multicenter prospective study of critical care patients with possible NHO. MAIN MEASURES: Following a screening clinical examination, the major joints were evaluated with US, serum laboratory work, and x-ray...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28190445/management-of-neurologic-complications-of-coagulopathies
#12
J D Vanderwerf, M A Kumar
Coagulopathy is common in intensive care units (ICUs). Many physiologic derangements lead to dysfunctional hemostasis; these may be either congenital or acquired. The most devastating outcome of coagulopathy in the critically ill is major bleeding, defined by transfusion requirement, hemodynamic instability, or intracranial hemorrhage. ICU coagulopathy often poses complex management dilemmas, as bleeding risk must be tempered with thrombotic potential. Coagulopathy associated with intracranial hemorrhage bears directly on prognosis and outcome...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28187810/management-of-infections-associated-with-neurocritical-care
#13
L Rivera-Lara, W Ziai, P Nyquist
The reported incidence of hospital-acquired infections (HAIs) in the neurointensive care unit (NICU) ranges from 20% to 30%. HAIs in US hospitals cost between $28 and $45 billion per year in direct medical costs. These infections are associated with increased length of hospital stay and increased morbidity and mortality. Infection risk is increased in NICU patients due to medication side-effects, catheter and line placement, neurosurgical procedures, and acquired immune suppression secondary to steroid/barbiturate use and brain injury itself...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28177169/emergency-department-triage-of-traumatic-head-injury-using-brain-electrical-activity-biomarkers-a-multisite-prospective-observational-validation-trial
#14
Daniel Hanley, Leslie S Prichep, Jeffrey Bazarian, J Stephen Huff, Rosanne Naunheim, John Garrett, Elizabeth Jones, David Wright, John O'Neill, Neeraj Badjatia, Dheeraj Gandhi, Kenneth C Curley, Richard Chiacchierini, Brian O'Neil, Dallas C Hack
OBJECTIVES: A brain electrical activity biomarker for identifying traumatic brain injury (TBI) in Emergency Department (ED) patients presenting with high GCS after sustaining a head injury has shown promise for objective, rapid, triage. The main objective of this study was to prospectively evaluate the efficacy of an automated classification algorithm to determine the likelihood of being CT positive, in high functioning TBI patients in the acute state. METHODS: Adult patients admitted to the ED for evaluation within 72 hours of sustaining a closed head injury with GCS 12-15were candidates for study...
February 8, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28167446/various-modifications-of-the-intrahippocampal-kainate-model-of-mesial-temporal-lobe-epilepsy-in-rats-fail-to-resolve-the-marked-rat-to-mouse-differences-in-type-and-frequency-of-spontaneous-seizures-in-this-model
#15
Rebecca Klee, Claudia Brandt, Kathrin Töllner, Wolfgang Löscher
Temporal lobe epilepsy (TLE) is the most common type of acquired epilepsy in adults. TLE can develop after diverse brain insults, including traumatic brain injury, infections, stroke, or prolonged status epilepticus (SE). Post-SE rodent models of TLE are widely used to understand mechanisms of epileptogenesis and develop treatments for epilepsy prevention. In this respect, the intrahippocampal kainate model of TLE in mice is of interest, because highly frequent spontaneous electrographic seizures develop in the kainate focus, allowing evaluation of both anti-seizure and anti-epileptogenic effects of novel drugs with only short EEG recording periods, which is not possible in any other model of TLE, including the intrahippocampal kainate model in rats...
February 3, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28163912/the-benefits-of-youth-are-lost-on-the-young-cardiac-arrest-patient
#16
REVIEW
Brian Griffith, Patrick Kochanek, Cameron Dezfulian
Children and young adults tend to have reduced mortality and disability after acquired brain injuries such as trauma or stroke and across other disease processes seen in critical care medicine. However, after out-of-hospital cardiac arrest (OHCA), outcomes are remarkably similar across age groups. The consistent lack of witnessed arrests and a high incidence of asphyxial or respiratory etiology arrests among pediatric and young adult patients with OHCA account for a substantial portion of the difference in outcomes...
2017: F1000Research
https://www.readbyqxmd.com/read/28162033/high-density-electroencephalographic-recordings-during-sleep-in-children-and-adolescents-with-acquired-brain-injury
#17
Anne-Laure Mouthon, Andreas Meyer-Heim, Salome Kurth, Maya Ringli, Fiona Pugin, Hubertus J A van Hedel, Reto Huber
BACKGROUND: Acquired brain injuries (ABI) such as traumatic brain injury (TBI) or stroke can result in motor, language, or cognitive impairments. Although a considerable number of studies have investigated functional recovery, underlying brain reorganization remains poorly understood. Accumulating evidence indicates that plastic processes in the brain are linked to changes in electroencephalographic (EEG) slow wave activity (SWA) during deep sleep (EEG spectral power 1-4.5 Hz). OBJECTIVE: We investigated sleep SWA in children and adolescents with ABI...
February 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28159618/musical-anhedonia-after-focal-brain-damage
#18
Amy M Belfi, Erin Evans, Jonah Heskje, Joel Bruss, Daniel Tranel
People listen to music because it is pleasurable. However, there are individual differences in the reward value of music. At the extreme low end of this continuum, individuals who derive no pleasure from music are said to have 'musical anhedonia.' Cases of acquired musical anhedonia following focal brain damage are rare, with only a handful having been reported in the scientific literature. Here, we surveyed a large sample of patients with focal brain damage to identify the frequency, specificity, and neural correlates of acquired musical anhedonia...
January 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28144771/the-first-six-years-of-building-and-implementing-a-return-to-work-service-for-patients-with-acquired-brain-injury-the-rapid-return-to-work-cohort-study
#19
L Haveraaen, E P M Brouwers, U Sveen, L S Skarpaas, H Sagvaag, R W Aas
Background and objective Despite large activity worldwide in building and implementing new return-to-work (RTW) services, few studies have focused on how such implementation processes develop. The aim of this study was to examine the development in patient and service characteristics the first six years of implementing a RTW service for persons with acquired brain injury (ABI). Methods The study was designed as a cohort study (n=189). Data were collected by questionnaires, filled out by the service providers...
January 31, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28128026/amide-proton-transfer-weighted-mri-detection-of-traumatic-brain-injury-in-rats
#20
Hong Zhang, Wenzhu Wang, Shanshan Jiang, Yi Zhang, Hye-Young Heo, Xianlong Wang, Yun Peng, Jian Wang, Jinyuan Zhou
The purpose of this study was to explore the capability and uniqueness of amide proton transfer-weighted (APTw) imaging in the detection of primary and secondary injury after controlled cortical impact (CCI)-induced traumatic brain injury (TBI) in rats. Eleven adult rats had craniotomy plus CCI surgery under isoflurane anesthesia. Multi-parameter MRI data were acquired at 4.7 T, at eight time points (1, 6 h, and 1, 2, 3, 7, 14, and 28 days after TBI). At one and six hours post-injury, average APTw signal intensities decreased significantly in the impacted and peri-lesional areas due to tissue acidosis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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