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acquired brain injury

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https://www.readbyqxmd.com/read/28934366/early-metabolite-changes-after-melatonin-treatment-in-neonatal-rats-with-hypoxic-ischemic-brain-injury-studied-by-in-vivo1h-mr-spectroscopy
#1
Hester Rijkje Berger, Axel K G Nyman, Tora Sund Morken, Riyas Vettukattil, Ann-Mari Brubakk, Marius Widerøe
Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after HI. Postnatal day 7 Sprague-Dawley rats with unilateral HI brain injury were treated with either melatonin 10 mg/kg dissolved in phosphate-buffered saline (PBS) with 5% dimethyl sulfoxide (DMSO) or vehicle (5% DMSO and/or PBS) directly and at 6 hours after HI. 1H MR spectra from the thalamus in the ipsilateral and contralateral hemisphere were acquired 1 day after HI...
2017: PloS One
https://www.readbyqxmd.com/read/28933607/a-randomised-controlled-trial-of-a-web-based-multi-modal-therapy-program-to-improve-executive-functioning-in-children-and-adolescents-with-acquired-brain-injury
#2
Adina Piovesana, Stephanie Ross, Owen Lloyd, Koa Whittingham, Jenny Ziviani, Robert S Ware, Lynne McKinlay, Roslyn N Boyd
OBJECTIVE: To examine the efficacy of a multi-modal web-based therapy program, Move it to improve it (Mitii™) delivered at home to improve Executive Functioning (EF) in children with an acquired brain injury (ABI). DESIGN: Randomised Waitlist controlled trial. SETTING: Home environment. PARTICIPANTS: Sixty children with an ABI were matched in pairs by age and intelligence quotient then randomised to either 20-weeks of Mitii™ training or 20 weeks of Care As Usual (waitlist control; n=30; 17 males; mean age=11y, 11m (±2y, 6m); Full Scale IQ=76...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28933193/examining-a-statewide-educational-consulting-program-for-pediatric-brain-injury
#3
Rachel K Myers, Brenda L Eagan-Brown, Alexandra T Conway, Drew A Nagele, Monica J Vaccaro, Sadiqa Kendi, Mark R Zonfrillo
This study describes characteristics of students with acquired brain injury enrolled in a statewide educational consultation program and the program's support activities. Utilizing deidentified data from a statewide brain injury school consultation program, descriptive analyses of demographic and injury characteristics, including medical diagnosis (concussion/mild traumatic brain injury [TBI], moderate-severe TBI, and non-TBI), referral characteristics, educational placement, and the types of program activities were undertaken...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28932205/face-and-word-recognition-can-be-selectively-affected-by-brain-injury-or-developmental-disorders
#4
REVIEW
Ro J Robotham, Randi Starrfelt
Face and word recognition have traditionally been thought to rely on highly specialised and relatively independent cognitive processes. Some of the strongest evidence for this has come from patients with seemingly category-specific visual perceptual deficits such as pure prosopagnosia, a selective face recognition deficit, and pure alexia, a selective word recognition deficit. Together, the patterns of impaired reading with preserved face recognition and impaired face recognition with preserved reading constitute a double dissociation...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28920523/the-social-consequences-of-stigma-related-self-concealment-after-acquired-brain-injury
#5
Barbara F Hagger, Gerard A Riley
Social relationships often decline after brain injury. Although much of this is due to psychosocial impairments caused by the injury, the reactions to the injury of others in the person's wider social network, along with the response of the person with the injury to those reactions, also need to be considered. Anxiety about stigmatising reactions from others may lead some to conceal information about their brain injury. This study investigated some of the social consequences of such concealment. Sixty-five participants with acquired brain injury completed the Anticipated Stigma and Concealment Questionnaire, the Social Avoidance and Distress Scale, the UCLA Loneliness Scale, the Rosenberg Self-Esteem Scale, the Social Integration subscale of the Community Integration Questionnaire, and the Enacted Social Support Questionnaire...
September 18, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28918207/the-association-between-cardiac-physiology-acquired-brain-injury-and-postnatal-brain-growth-in-critical-congenital-heart-disease
#6
Shabnam Peyvandi, Hosung Kim, Joanne Lau, A James Barkovich, Andrew Campbell, Steven Miller, Duan Xu, Patrick McQuillen
OBJECTIVE: To assess the trajectory of perioperative brain growth in relationship to cardiac diagnosis and acquired brain injuries. METHODS: This was a cohort study of term neonates with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA). Subjects underwent magnetic resonance imaging of the brain pre- and postoperatively to determine the severity of brain injury and total and regional brain volumes by the use of automated morphometry...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28898132/staged-residential-post-acute-rehabilitation-for-adults-following-acquired-brain-injury-a-comparison-of-functional-gains-rated-on-the-uk-functional-assessment-measure-uk-fim-fam-and-the-mayo-portland-adaptability-inventory-mpai-4
#7
Diana Jackson, Karla Seaman, Kristylee Sharp, Rachel Singer, Janet Wagland, Lynne Turner-Stokes
OBJECTIVE: To compare the UK Functional Assessment Measure (UK FIM+FAM) and Mayo-Portland Adaptability Inventory (MPAI-4) as measures of functional change in patients with brain injury receiving a staged residential post-acute community-based rehabilitation programme. RESEARCH DESIGN: Longitudinal cohort study of consecutive admissions (N = 42) over 3 years. METHODS: Patients were assessed at admission and discharge/annual review. We examined groups according to stage of independence on admission: Maximum support (stages 1 and 2: N = 17); moderate/maximum self-care/household support (stage 3: N = 15); minimal self-care and moderate household/community support (stages 4-6: N = 10)...
September 12, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28895796/prevalence-and-severity-of-fatigue-in-adolescents-and-young-adults-with-acquired-brain-injury-a-nationwide-study
#8
Anne Norup, Susanne Wulff Svendsen, Karoline Doser, Trine Okkerstrøm Ryttersgaard, Nicole Frandsen, Louise Gade, Hysse Birgitte Forchhammer
OBJECTIVE: To investigate the prevalence and severity of fatigue in adolescents and young adults with acquired brain injury (ABI) compared with healthy controls (HCs) and to examine associations between fatigue and gender, age and level of education. METHODS: This cross-sectional study included 15-30 year old patients with ABI and a convenience sample of 15-30 year old HCs. All participants completed the 20-item Multidimensional Fatigue Inventory (MFI-20). Pathological fatigue was defined as "General Fatigue" ≥12...
September 12, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28894296/test-retest-reliability-of-high-spatial-resolution-diffusion-tensor-and-diffusion-kurtosis-imaging
#9
Pashtun Shahim, Laurena Holleran, Joong H Kim, David L Brody
We assessed the test-retest reliability of high spatial resolution diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80 mT/m gradients and a 32-channel head coil from each of 3 concussive traumatic brain injury (cTBI) patients and 4 controls twice 0 to 24 days apart. Coefficients of variation (CoV) for DTI parameters were calculated in each DTI Studio parcellated white matter tract at 1.25 mm and 1.75 mm isotropic voxel resolution, as well as DKI parameters at 1...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890524/diagnosis-and-management-of-patients-with-paroxysmal-sympathetic-hyperactivity-following-acute-brain-injuries-using-a-consensus-based-diagnostic-tool-a-single-institutional-case-series
#10
Shigeo Godo, Shigemi Irino, Atsuhiro Nakagawa, Yu Kawazoe, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Paroxysmal sympathetic hyperactivity (PSH) is a distinct syndrome of episodic sympathetic hyperactivities following severe acquired brain injury, characterized by paroxysmal transient fever, tachycardia, hypertension, tachypnea, excessive diaphoresis and specific posturing. PSH remains to be an under-recognized condition with a diagnostic pitfall especially in the intensive care unit (ICU) settings due to the high prevalence of concomitant diseases that mimic PSH. A consensus set of diagnostic criteria named PSH-Assessment Measure (PSH-AM) has been developed recently, which is consisted of two components: a diagnosis likelihood tool derived from clinical characteristics of PSH, and a clinical feature scale assigned to the severity of each sympathetic hyperactivity...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28885567/metabolic-and-homeostatic-changes-in-seizures-and-acquired-epilepsy-mitochondria-calcium-dynamics-and-reactive-oxygen-species
#11
REVIEW
Stjepana Kovac, Albena T Dinkova Kostova, Alexander M Herrmann, Nico Melzer, Sven G Meuth, Ali Gorji
Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major challenge to clinicians as they are present in the majority of patients seen in a common outpatient epilepsy clinic and are prone to pharmacoresistance, highlighting an unmet need for new treatment strategies. Metabolic and homeostatic changes are closely linked to seizures and epilepsy, although, surprisingly, no potential treatment targets to date have been translated into clinical practice...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28877737/erratum-to-a-manual-based-vocational-rehabilitation-program-for-patients-with-an-acquired-brain-injury-study-protocol-of-a-pragmatic-randomized-controlled-trial-rct
#12
Louise K Hoeffding, Maria Haahr Nielsen, Morten A Rasmussen, Anne Norup, Juan Carlos Arango-Lasprilla, Ulrikka K Kjær, Kristoffer Sølvsten Burgdorf, Kirsten Jensen Quas, Trine Schow
No abstract text is available yet for this article.
September 6, 2017: Trials
https://www.readbyqxmd.com/read/28873890/participation-and-autonomy-for-users-with-abi-through-easy-social-media-access
#13
Susanne Dirks, Christian Bühler
The Mediata app is a mobile application providing easy access to internet and social media for persons with acquired brain injury. This paper presents design, working hypotheses and expected results of a participative user experience study to evaluate the impact of the Mediata application on participation and autonomy of users with acquired brain injury.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28870419/healthy-body-healthy-mind-a-mixed-methods-study-of-outcomes-barriers-and-supports-for-exercise-by-people-who-have-chronic-moderate-to-severe-acquired-brain-injury
#14
Laura S Lorenz, Ann L Charrette, Therese M O'Neil-Pirozzi, Julia M Doucett, Jeffrey Fong
BACKGROUND: Few people with chronic moderate-to-severe brain injury are following recommended physical activity guidelines. OBJECTIVE: Investigate effects of planned, systematic physical activity while cultivating social and emotional well-being of people with chronic moderate-to-severe brain injury. HYPOTHESIS: Moderate-to-intensive physical activity would be associated with improvements in impairment and activity limitation measures (endurance, mobility, gait speed) immediately post-intervention and six weeks later (study week 12)...
August 24, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28860106/web-based-mindfulness-interventions-for-people-with-physical-health-conditions-systematic-review
#15
Kirsti I Toivonen, Kristin Zernicke, Linda E Carlson
BACKGROUND: Mindfulness-based interventions (MBIs) are becoming increasingly popular for helping people with physical health conditions. Expanding from traditional face-to-face program delivery, there is growing interest in Web-based application of MBIs, though Web-based MBIs for people with physical health conditions specifically have not been thoroughly reviewed to date. OBJECTIVE: The objective of this paper was to review Web-based MBIs for people with physical health conditions and to examine all outcomes reported (eg, efficacy or effectiveness for physical changes or psychological changes; feasibility)...
August 31, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28858401/histopathology-of-middle-east-respiratory-syndrome-coronovirus-mers-cov-infection-clinicopathological-and-ultrastructural-study
#16
Khaled O Alsaad, Ali H Hajeer, Mohammed Al Balwi, Mohammed Al Moaiqel, Nourah Al Oudah, Abdulaziz Al Ajlan, Sameera AlJohani, Sami Alsolamy, Giamal E Gmati, Hanan Balkhy, Hamdan H Al-Jahdali, Salim A Baharoon, Yaseen M Arabi
AIMS: The pathogenesis, viral localization and histopathological features of Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) in human are not sufficiently described. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology. METHODS AND RESULTS: We analyzed the postmortem histopathological findings and investigated viral particles localization in the pulmonary and extra-pulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T-cell lymphoma, who acquired MERS-CoV infection...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28856486/the-automated-assessment-of-postural-stability-balance-detection-algorithm
#17
Alessandro Napoli, Stephen M Glass, Carole Tucker, Iyad Obeid
Impaired balance is a common indicator of mild traumatic brain injury, concussion and musculoskeletal injury. Given the clinical relevance of such injuries, especially in military settings, it is paramount to develop more accurate and reliable on-field evaluation tools. This work presents the design and implementation of the automated assessment of postural stability (AAPS) system, for on-field evaluations following concussion. The AAPS is a computer system, based on inexpensive off-the-shelf components and custom software, that aims to automatically and reliably evaluate balance deficits, by replicating a known on-field clinical test, namely, the Balance Error Scoring System (BESS)...
August 30, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28845724/adding-insult-to-brain-injury-young-adults-experiences-of-residing-in-nursing-homes-following-acquired-brain-injury
#18
Aoife Dwyer, Caroline Heary, Marcia Ward, Pádraig MacNeela
PURPOSE: There is general consensus that adults under age 65 with acquired brain injury residing in nursing homes is inappropriate, however there is a limited evidence base on the issue. Previous research has relied heavily on third-party informants and qualitative studies have been of questionable methodological quality, with no known study adopting a phenomenological approach. This study explored the lived experiences of young adults with brain injury residing in aged care facilities...
August 28, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28844645/direct-electrical-stimulation-in-the-human-brain-disrupts-melody-processing
#19
Frank E Garcea, Benjamin L Chernoff, Bram Diamond, Wesley Lewis, Maxwell H Sims, Samuel B Tomlinson, Alexander Teghipco, Raouf Belkhir, Sarah B Gannon, Steve Erickson, Susan O Smith, Jonathan Stone, Lynn Liu, Trenton Tollefson, John Langfitt, Elizabeth Marvin, Webster H Pilcher, Bradford Z Mahon
Prior research using functional magnetic resonance imaging (fMRI) [1-4] and behavioral studies of patients with acquired or congenital amusia [5-8] suggest that the right posterior superior temporal gyrus (STG) in the human brain is specialized for aspects of music processing (for review, see [9-12]). Intracranial electrical brain stimulation in awake neurosurgery patients is a powerful means to determine the computations supported by specific brain regions and networks [13-21] because it provides reversible causal evidence with high spatial resolution (for review, see [22, 23])...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28837360/assessment-of-needs-psychological-impact-and-quality-of-life-in-families-of-patients-with-locked-in-syndrome
#20
Zulay Lugo, Fréderic Pellas, Veronique Blandin, Steven Laureys, Olivia Gosseries
OBJECTIVE: Family needs of patients with acquired brain injuries have been studied for about three decades. In this study, we assessed the needs, the quality of life and the psychological state of relatives of patients with locked-in syndrome (LIS). DESIGN: A survey was carried out using the family needs' questionnaire (FNQ). SUBJECTS AND METHODS: Thirty relatives of patients with LIS fully completed the FNQ. RESULTS: The most important need reported by families corresponded to the need for medical information...
August 24, 2017: Brain Injury: [BI]
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