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acquired brain injury

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https://www.readbyqxmd.com/read/28543689/mild-cognitive-impairment-and-structural-brain-abnormalities-in-a-sexagenarian-with-a-history-of-childhood-traumatic-brain-injury
#1
John Darrell Van Horn, Andrei Irimia, Carinna M Torgerson, Avnish Bhattrai, Zachary Jacokes, Paul M Vespa
In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD)...
May 20, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28542743/neuroimaging-cardiovascular-physiology-and-functional-outcomes-in-infants-with-congenital-heart-disease
#2
REVIEW
Nathalie H P Claessens, Christopher J Kelly, Serena J Counsell, Manon J N L Benders
This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time...
May 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28538329/perioperative-care-for-pediatric-patients-with-penetrating-brain-injury-a-review
#3
Marco Mikhael, Elizabeth Frost, Maria Cristancho
Traumatic brain injury (TBI) continues to be the leading cause of death and acquired disability in young children and adolescents, due to blunt or penetrating trauma, the latter being less common but more lethal. Penetrating brain injury (PBI) has not been studied extensively, mainly reported as case reports or case series, due to the assumption that both types of brain injury have common pathophysiology and consequently common management. However, recommendations and guidelines for the management of PBI differ from those of blunt TBI in regards to neuroimaging, intracranial pressure (ICP) monitoring, and surgical management including those pertaining to vascular injury...
May 19, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28536273/metal-transporter-zip14-slc39a14-deletion-in-mice-increases-manganese-depositionnd-produces-neurotoxic-signaturesnd-diminished-motorctivity
#4
Tolunay Bekerydemir, Min-Hyun Kim, Jinhee Kim, Luis M Colon-Perez, Guita Banan, Thomas H Mareci, Marcelo Febo, Robert J Cousins
Mutations in human ZIP14 have been linked to symptoms of early onset of Parkinsonismnd Dystonia. This phenotype is likely related to excess manganeseccumulation in the central nervous system. The metal transporter ZIP14 (SLC39A14) is viewed primarilys zinc transporter that is inducible via proinflammatory stimuli. In vitro evidence shows that ZIP14 canlso transport manganese. To examine role for ZIP14 in manganese homeostasis, we used Zip14 knockout (KO) malend female mice to conduct comparative metabolic, imagingnd functional studies...
May 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28532322/the-overt-behaviour-scale-self-report-obs-sr-for-acquired-brain-injury-exploratory-analysis-of-reliability-and-validity
#5
Glenn Kelly, Grahame K Simpson, Suzanne Brown, Peter Kremer, Lauren Gillett
The objectives were to test the properties, via a psychometric study, of the Overt Behaviour Scale-Self-Report (OBS-SR), a version of the OBS-Adult Scale developed to provide a client perspective on challenging behaviours after acquired brain injury. Study sample 1 consisted of 37 patients with primary brain tumour (PBT) and a family-member informant. Sample 2 consisted of 34 clients with other acquired brain injury (mixed brain injury, MBI) and a service-provider informant. Participants completed the OBS-SR (at two time points), and the Awareness Questionnaire (AQ) and Mayo Portland Adaptability Inventory-III (MPAI-III) once; informants completed the OBS-Adult and AQ once only...
May 23, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28524212/-infantile-acquired-brain-injury-a-personal-experience-demands-from-the-socio-familial-point-of-view
#6
P Pastor-Alfonso
We report on the experience of a family in which the youngest child has acquired brain injury and the struggle undertaken by the family to improve the neurorehabilitation resources in the public health service. The article outlines the main demands, from the socio-familial point of view, as regards the improvement of neurological rehabilitation and the resources needed to deliver it.
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28524211/-rehabilitation-treatment-in-child-and-youth-patients-with-acquired-brain-injury
#7
M T Varas-Arias, S Rodriguez-Palero
Brain injury is one of the most frequent causes of death and disability in the child and adolescent. The improvement in patient care in the acute moment and the evolution of health care has meant and increase in the survival of these patients and also of the sequelae. Physical, cognitive-behavioral or organic symptoms are usually. The second is being one of the most frequent and most limiting in these patients. The brain injury affects the patient but involves the whole family because of the disability and the dependence it entails...
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28521554/social-factors-predictive-of-social-integration-for-adults-with-brain-injury
#8
Elisabeth Batchos, Amanda Easton, Christopher Haak, Nicole Ditchman
INTRODUCTION: Individuals with acquired brain injury (ABI) may not only struggle with physical and cognitive impairments, but may also face challenges reintegrating into the community socially. Research has demonstrated that following ABI, individuals' social networks tend to dwindle, support may decline, and isolation increases. This study examined factors impacting social integration in a community-based sample of 102 individuals with ABI. METHODS: Potential predictors included emotional support, instrumental support, problem solving confidence, and approach-avoidance style (AAS) of problem solving, while controlling for age, gender, education, and time since injury...
May 18, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28512065/long-term-functional-and-psychosocial-outcomes-after-hypoxic-ischemic-brain-injury-a-case-controlled-comparison-to-traumatic-brain-injury
#9
Meredith Harbinson, Sareh Zarshenas, Nora Cullen
BACKGROUND: Despite the increasing rate of survival from Hypoxic-Ischemic Brain Injury (HIBI), there is a paucity of evidence on the long-term functional outcomes after inpatient rehabilitation among these non-traumatic patients compared to patients with Traumatic Brain injury (TBI). OBJECTIVES: To compare functional and psychosocial outcomes of patients with HIBI vs. case-matched patients with TBI 4 to11 years after brain insult. DESIGN: Retrospective, matched case-controlled study...
May 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28505355/uncovering-the-neuroanatomical-correlates-of-cognitive-affective-and-conative-theory-of-mind-in-pediatric-traumatic-brain-injury-a-neural-systems-perspective
#10
Nicholas P Ryan, Cathy Catroppa, Richard Beare, Timothy J Silk, Stephen J Hearps, Miriam H Beauchamp, Keith Owen Yeates, Vicki A Anderson
Deficits in Theory of Mind (ToM) are common after neurological insult acquired in the first and second decade of life, however the contribution of large-scale neural networks to ToM deficits in children with brain injury is unclear. Using pediatric traumatic brain injury (TBI) as a model, this study investigated the sub-acute effect of brain injury on gray-matter volume of three large-scale, domain-general brain networks (the Default Mode Network, DMN; the Central Executive Network, CEN; and the Salience Network, SN), as well as two domain-specific neural networks implicated in social-affective processes (the Cerebro-Cerebellar Mentalizing Network, CCMN, and the Mirror Neuron/Empathy Network, MNEN)...
May 15, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28494632/children-s-and-teachers-perspectives-on-adjustments-needed-in-school-settings-after-acquired-brain-injury
#11
Cornelia Kocher Stalder, Anders Kottorp, Maja Steinlin, Helena Hemmingsson
BACKGROUND: Children with acquired brain injury (ABI) often present with functional deficits that influence their societal participation and well-being. Successful reintegration into school calls for individual support to meet each child's adjustment needs. The adjustment needs of children with ABI in school settings have not previously been explored. AIM: The objectives of the present study were (a) to describe adjustment needs in school settings for children with ABI and (b) to explore differences and similarities between reports from the children and their teachers...
May 11, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28489702/the-minimal-clinically-important-difference-for-the-mayo-portland-adaptability-inventory
#12
James F Malec, Jacob Kean, Patrick O Monahan
OBJECTIVES: To determine the Minimal Clinically Important Difference (MCID) and Robust Clinically Important Difference (RCID) of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) as measures of response to intervention. METHODS: Retrospective analysis of existing data. Both distribution- and anchor-based methods were used to triangulate on the MCID and to identify a moderate, that is, more robust, level of change (RCID) for the MPAI-4. These were further evaluated with respect to clinical provider ratings...
November 8, 2016: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28481652/when-a-parent-suffers-abi-investigation-of-emotional-distress-in-children
#13
A Redolfi, G Bartolini, M Gugliotta, A Maietti, P Pietrapiana, S Sapienza, A D'Amato, A Mazzucchi
PRIMARY OBJECTIVE: To investigate the type of emotional and behavioural impact that having a parent with a severe acquired brain injury (ABI) has on children during the first period of adjustment. METHODS AND PROCEDURE: The study involved 25 couples in which one of the spouses was affected by ABI, and their 35 children (3-14 years). The children attended three sessions with a psychologist aimed at identifying their spontaneous playing and relational behaviour by means of a grid created on the basis of ICD-10 criteria...
May 8, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28479568/portable-qeeg-and-hd-tcs-device-for-point-of-injury-traumatic-brain-injury-diagnostics
#14
Frode Strisland, Jon Vedum, Anders Liverud, Steffen Dalgard, Tomas Brødreskift, Bruno Albert, Alexandre Noyvirt, Rossitza Setchi, Karl Vene, Henrik Herranen, Maarjus Kirs, Andrea Antal, Klaus Schellhorn, Haldor Sjaaheim
Mild Traumatic Brain Injury (mTBI) can cause prolonged or permanent injuries if left undetected and ignored. It is therefore of great interest to lower the threshold for diagnosis of individuals with mTBI injury. We report on the development of a prototype of a portable quantified EEG (qEEG) system intended for in-the-field mTBI diagnostics. The 32-electrode system is fully battery driven, is interfaced with a control unit being part of a telemedicine care system. Electrode montage is a central problem effectively challenging measurements outside clinical environments...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28471767/pharmacological-stimulation-of-neuronal-plasticity-in-acquired-brain-injury
#15
Paul Carrillo-Mora, Juan Manuel Alcantar-Shramm, Kievka M Almaguer-Benavides, Julio José Macías-Gallardo, Alim Fuentes-Bello, Marlene A Rodríguez-Barragán
INTRODUCTION: Brain injuries are one of the leading causes of disability worldwide. It is estimated that nearly half of patients who develop severe sequelae will continue with a chronic severe disability despite having received an appropriate rehabilitation program. For more than 3 decades, there has been a worldwide effort to investigate the possibility of pharmacologically stimulating the neuroplasticity process for enhancing the recovery of these patients. OBJECTIVE: The objective of this article is to make a critical and updated review of the available evidence that supports the positive effect of different drugs on the recovery from brain injury...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28469499/a-case-of-statin-associated-autoimmune-myopathy
#16
Alexander J Sweidan, Anthony Leung, Cassandra J Kaiser, Sarah J Strube, Andrei N Dokukin, Stephen Romansky, Sassan Farjami
A 70-year-old previously independent man developed progressive proximal leg weakness resulting in a fall at home suffering traumatic brain injury. He was prescribed a statin medication two years prior, but this was discontinued on admission to the hospital due to concern for statin myopathy. His weakness continued to progress while in acute rehabilitation, along with the development of dysphagia requiring placement of gastrostomy tube and respiratory failure requiring tracheostomy. Corticosteroids and intravenous immunoglobulin were administered without response...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28465136/semantic-memory-deficits-are-associated-with-pica-in-individuals-with-acquired-brain-injury
#17
Michitaka Funayama, Taro Muramatsu, Akihiro Koreki, Motoichiro Kato, Masaru Mimura, Yoshitaka Nakagawa
Although pica is one of the most prominent signs in individuals with severe cognitive impairment, the mechanisms and neural basis for pica have not been well elucidated. To address this issue, patients with acquired brain injury who showed pica and hyperorality were investigated. Eleven patients with pica, i.e., individuals who eat non-food items, and eight patients with hyperorality but who never eat non-food items were recruited. The cognitive and behavioral assessments and neural substrates of the two groups were compared...
April 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28447806/blame-coping-and-psychosocial-outcomes-in-caregivers-of-individuals-with-brain-injury
#18
Samantha DeDios-Stern, Eun-Jeong Lee
OBJECTIVE: Acquired brain injury (ABI) is associated with many physical and psychiatric conditions. Oftentimes, the individual's family members are responsible for providing long-term care, leaving caregivers vulnerable to negative effects of caregiving including stress, depression, and decreased quality of life. Attribution theory suggests that caregivers may blame the individual with the ABI for their injury as a way to understand their own circumstances. The objective of this study was to investigate caregiver coping strategies as possible mediators between caregiver family member blame and caregiver psychosocial outcomes among caregivers of individuals with ABI...
April 27, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28444554/relationships-between-environmental-factors-and-participation-in-adults-with-traumatic-brain-injury-stroke-and-spinal-cord-injury-a-cross-sectional-multi-center-study
#19
Alex W K Wong, Sheryl Ng, Jessica Dashner, M Carolyn Baum, Joy Hammel, Susan Magasi, Jin-Shei Lai, Noelle E Carlozzi, David S Tulsky, Ana Miskovic, Arielle Goldsmith, Allen W Heinemann
PURPOSE: To develop and evaluate a model of environmental factors-participation relationships for persons with traumatic brain injury (TBI), stroke, and spinal cord injury (SCI), and test whether this model differed across three diagnostic groups, as well as other demographic and clinical characteristics. METHODS: A cross-sectional observational study included 545 community-dwelling adults with neurological disorders (TBI = 166; stroke = 189; SCI = 190) recruited at three academic medical centers...
April 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28444141/imaging-blood-brain-barrier-dysfunction-as-a-biomarker-for-epileptogenesis
#20
Guy Bar-Klein, Svetlana Lublinsky, Lyn Kamintsky, Iris Noyman, Ronel Veksler, Hotjensa Dalipaj, Vladimir V Senatorov, Evyatar Swissa, Dror Rosenbach, Netta Elazary, Dan Z Milikovsky, Nadav Milk, Michael Kassirer, Yossi Rosman, Yonatan Serlin, Arik Eisenkraft, Yoash Chassidim, Yisrael Parmet, Daniela Kaufer, Alon Friedman
A biomarker that will enable the identification of patients at high-risk for developing post-injury epilepsy is critically required. Microvascular pathology and related blood-brain barrier dysfunction and neuroinflammation were shown to be associated with epileptogenesis after injury. Here we used prospective, longitudinal magnetic resonance imaging to quantitatively follow blood-brain barrier pathology in rats following status epilepticus, late electrocorticography to identify epileptic animals and post-mortem immunohistochemistry to confirm blood-brain barrier dysfunction and neuroinflammation...
April 23, 2017: Brain: a Journal of Neurology
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