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acquired brain injury

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https://www.readbyqxmd.com/read/28716537/participant-and-service-provider-perceptions-of-an-outpatient-rehabilitation-program-for-people-with-acquired-brain-injury
#1
Frédérique Poncet, Pascale Pradat-Diehl, Marie-Eve Lamontagne, Anne Alifax, Pascaline Fradelizi, Maude Barette, Bonnie Swaine
BACKGROUND: A holistic, intensive and interdisciplinary rehabilitation program for people with acquired brain injury (ABI) was developed at the Pitié-Salpêtrière Hospital, France (5 days/week for 7 weeks). This program, recently demonstrated effective, aimed to optimize the ability of people with ABI to perform activities and improve their participation by using individual and group interventions involving ecologically valid activities inside (e.g., in the gym and kitchen) and outside the hospital...
July 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28716153/a-nested-mechanistic-sub-study-into-the-effect-of-tranexamic-acid-versus-placebo-on-intracranial-haemorrhage-and-cerebral-ischaemia-in-isolated-traumatic-brain-injury-study-protocol-for-a-randomised-controlled-trial-crash-3-trial-intracranial-bleeding-mechanistic
#2
Abda Mahmood, Ian Roberts, Haleema Shakur
BACKGROUND: Tranexamic acid prevents blood clots from breaking down and reduces bleeding. However, it is uncertain whether tranexamic acid is effective in traumatic brain injury. The CRASH-3 trial is a randomised controlled trial that will examine the effect of tranexamic acid (versus placebo) on death and disability in 13,000 patients with traumatic brain injury. The CRASH-3 trial hypothesizes that tranexamic acid will reduce intracranial haemorrhage, which will reduce the risk of death...
July 17, 2017: Trials
https://www.readbyqxmd.com/read/28710215/a-study-protocol-for-an-observational-cohort-investigating-cognitive-outcomes-and-wellness-in-survivors-of-critical-illness-the-cogwell-study
#3
M Elizabeth Wilcox, Andrew S Lim, Mary P McAndrews, Richard A Wennberg, Ruxandra L Pinto, Sandra E Black, Karolina D Walczak, Jan O Friedrich, Michael S Taglione, Gordon D Rubenfeld
INTRODUCTION: Up to 9 out of 10 intensive care unit (ICU) survivors will suffer some degree of cognitive impairment at hospital discharge and approximately half will have decrements that persist for years. The mechanisms for this newly acquired brain injury are poorly understood. The purpose of this study is to describe the prevalence of sleep abnormalities and their association with cognitive impairment, examine a well-known genetic risk factor for dementia (Apolipoprotein E ε4) that may allow for genetic risk stratification of ICU survivors at greatest risk of cognitive impairment and determine if electroencephalography (EEG) is an independent predictor of long-term cognitive impairment and possibly a candidate intermediate end point for future clinical trials...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702354/white-matter-integrity-in-dyskinetic-cerebral-palsy-relationship-with-intelligence-quotient-and-executive-function
#4
Olga Laporta-Hoyos, Kerstin Pannek, Júlia Ballester-Plané, Lee B Reid, Élida Vázquez, Ignacio Delgado, Leire Zubiaurre-Elorza, Alfons Macaya, Pilar Póo, Mar Meléndez-Plumed, Carme Junqué, Roslyn Boyd, Roser Pueyo
BACKGROUND: Dyskinetic cerebral palsy (CP) is one of the most disabling motor types of CP and has been classically associated with injury to the basal ganglia and thalamus. Although cognitive dysfunction is common in CP, there is a paucity of published quantitative analyses investigating the relationship between white matter (WM) microstructure and cognition in this CP type. AIMS: This study aims (1) to compare brain WM microstructure between people with dyskinetic CP and healthy controls, (2) to identify brain regions where WM microstructure is related to intelligence and (3) to identify brain regions where WM microstructure is related to executive function in people with dyskinetic CP and (4) to identify brain regions where the correlations are different between controls and people with CP in IQ and executive functions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28700588/years-of-life-lost-due-to-traumatic-brain-injury-in-europe-a-cross-sectional-analysis-of-16-countries
#5
Marek Majdan, Dominika Plancikova, Andrew Maas, Suzanne Polinder, Valery Feigin, Alice Theadom, Martin Rusnak, Alexandra Brazinova, Juanita Haagsma
INTRODUCTION: Traumatic brain injuries (TBIs) are a major public health, medical, and societal challenge globally. They present a substantial burden to victims, their families, and the society as a whole. Although indicators such as incidence or death rates provide insight into the occurrence and outcome of TBIs in various populations, they fail to quantify the full extent of their public health and societal impact. Measures such as years of life lost (YLLs), which quantifies the number of years of life lost because the person dies prematurely due to a disease or injury, should be employed to better quantify the population impact...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28698267/clinical-criteria-for-tracheostomy-decannulation-in-subjects-with-acquired-brain-injury
#6
Claudia Enrichi, Irene Battel, Cristiano Zanetti, Isabella Koch, Laura Ventura, Katie Palmer, Francesca Meneghello, Francesco Piccione, Simonetta Rossi, Marta Lazzeri, Maurizio Sommariva, Andrea Turolla
BACKGROUND: Patients with acquired brain injury (ABI) often require long periods of having a tracheostomy tube for airway protection and prolonged mechanical ventilation. It has been recognized that fast and safe decannulation improves outcomes and facilitates the recovery process. Nevertheless, few studies have provided evidence for decannulation criteria, despite the high prevalence of ABI subjects with tracheostomies. The aim of our study was to assess which clinical parameters are the best predictors for decannulation in subjects with ABI...
July 11, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28697674/training-adults-with-acquired-brain-injury-how-to-help-seek-when-wayfinding-an-understudied-critical-life-skill
#7
Young Susan Cho, McKay Moore Sohlberg, Richard Albin, Leonard Diller, Robert Horner, Joseph Rath, Michael Bullis
The objective of this study was to investigate the efficacy of a group treatment protocol called NICE (Noticing you have a problem, Identifying the information you need for help, Compensatory strategies, Evaluating progress) to train help-seeking when wayfinding for individuals with acquired brain injury (ABI). Seven participants completed the NICE group treatment in an outpatient rehabilitation department at a university medical centre. A single subject multiple baseline design was employed to evaluate the efficacy of the NICE group treatment...
July 11, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28695311/aberrant-paramagnetic-signals-outside-the-tumor-volume-on-routine-surveillance-mri-of-brain-tumor-patients
#8
Shlomit Yust-Katz, Edna Inbar, Natalia Michaeli, Dror Limon, Tali Siegal
Late complications of cerebral radiation therapy (RT) involve vascular injury with acquired cavernous malformation, telangiectasias and damage to vascular walls which are well recognized in children. Its incidence in adults is unknown. Blood products and iron deposition that accompany vascular injury create paramagnetic effects on MRI. This study retrospectively investigated the frequency of paramagnetic lesions on routine surveillance MRI of adult brain tumor patients. MRI studies of 115 brain tumor patients were reviewed...
July 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28694613/cognitive-and-functional-outcomes-following-inpatient-rehabilitation-in-patients-with-acquired-brain-injury-a-prospective-follow-up-study
#9
Maitreyi Patil, Anupam Gupta, Meeka Khanna, Arun B Taly, Amit Soni, J Keshav Kumar, K Thennarasu
OBJECTIVES: To study the effects of cognitive retraining and inpatient rehabilitation to study the effects of cognitive retraining and inpatient rehabilitation in patients with acquired brain injury (ABI). DESIGN AND SETTING: This was a prospective follow-up study in a neurological rehabilitation department of quaternary research hospital. PATIENTS AND METHODS: Thirty patients with ABI, mean age 36.43 years (standard deviation [SD] 12.6, range 18-60), mean duration of illness 77...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28691532/is-the-effect-of-coping-styles-disease-specific-relationships-with-emotional-distress-and-quality-of-life-in-acquired-brain-injury-and-multiple-sclerosis
#10
Ingrid Brands, Yvonne Bol, Sven Stapert, Sebastian Köhler, Caroline van Heugten
OBJECTIVE: To investigate the use of coping styles and the relationships linking coping to emotional distress and quality of life in patients with acquired brain injury and multiple sclerosis. METHOD: Cross-sectional cohort study of 143 patients with acquired brain injury and 310 patients with multiple sclerosis in the chronic stage. Quality of life was measured with the Life Satisfaction Questionnaire (LiSat-9), coping styles with the Coping Inventory for Stressful Situations (CISS-T, task-oriented; CISS-E, emotion-oriented; CISS-A, avoidance), emotional distress with the Hospital Anxiety and Depression Scale (HADS)...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28678658/description-of-a-multifaceted-intervention-programme-for-fatigue-after-acquired-brain-injury-a-pilot-study
#11
Jan Stubberud, Espen Edvardsen, Anne-Kristine Schanke, Anners Lerdal, Anita Kjeverud, Andreas Schillinger, Marianne Løvstad
The purpose of this pilot study was to describe and explore a group-based multifaceted intervention for patients with fatigue after acquired brain injury (ABI). We hypothesised that post-intervention changes would result in reduced fatigue, in addition to improved emotional health, sleep and attentional control. Eight subjects with traumatic brain injury (n = 3) and cerebrovascular insults (n = 5) were included. Inclusion was based upon the presence of fatigue complaints. The participants received 36 hours of intervention...
July 5, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28676352/assessment-of-neuro-optometric-rehabilitation-using-the-developmental-eye-movement-dem-test-in-adults-with-acquired-brain-injury
#12
Neera Kapoor, Kenneth Joseph Ciuffreda
PURPOSE: This pilot study sought to determine the efficacy of using the Developmental Eye Movement (DEM) test in the adult, acquired brain injury (ABI) population to quantify clinically the effects of controlled, laboratory-performed, oculomotor-based vision therapy/vision rehabilitation. METHODS: Nine adult subjects with mild traumatic brain injury (mTBI) and five with stroke were assessed before and after an eight-week, computer-based, versional oculomotor (fixation, saccades, pursuit, and simulated reading) training program (9...
July 1, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28672375/ecologically-valid-assessment-of-prospective-memory-for-task-planning-and-execution-by-adults-with-acquired-brain-injury
#13
Jessica Brown, Karen Hux
Purpose: Individuals with acquired brain injury (ABI) often struggle due to inadequate planning and execution skills for completing nonroutine tasks. This study's purpose was to pilot ecologically valid procedures to assess planning for and execution of prospective daily activities. Method: Participants included 9 adults with histories of severe ABI and 9 controls. Data collection included both prospective task planning and execution. First, participants created a plan for later execution of daily tasks in accordance with preestablished rules...
July 3, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28665697/feasibility-stability-and-validity-of-the-four-square-step-test-in-typically-developed-children-and-children-with-brain-damage
#14
Gil Leizerowitz, Michal Katz-Leurer
PURPOSE: To assess feasibility, test-retest reliability and validity of the Four Square Step Test (FSST) in typically developed children (TD), and children with cerebral palsy (CP) and acquired brain injury (ABI). METHODS: 30 TD children, 20 with CP and 12 with ABI participated in the study. The FSST while sitting and standing, the Timed Up and Go (TUG) and the balance subtest of the Bruininks-Oseretsky Test (BOT-2) were assessed. Each child attempted the FSST twice within 1 week...
June 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28661947/computer-based-cognitive-rehabilitation-interventions-for-traumatic-brain-injury-a-critical-review-of-the-literature
#15
REVIEW
Joseph Fetta, Angela Starkweather, Jessica M Gill
BACKGROUND: Computer-based interventions have been developed to improve cognitive performance after mild traumatic brain injury; however, a thorough evaluation of this body of research has not been addressed in the literature. OBJECTIVES: The aim of this study was to provide a synthesis and critical review of current research studies that have tested the efficacy of computer-based interventions on cognitive performance after mild traumatic brain injury. METHODS: A critical review was conducted by identifying relevant studies in the electronic databases PubMed/MEDLINE, PsycInfo, and CINAHL from 2011 to the present...
August 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28659494/application-of-ftir-spectroscopy-for-traumatic-axonal-injury-a-possible-tool-for-estimating-injury-interval
#16
Ji Zhang, Ping Huang, Zhenyuan Wang, Hongmei Dong
Traumatic axonal injury (TAI) is a progressive and secondary injury following traumatic brain injury (TBI). Despite extensive investigations in the field of forensic science and neurology, no effective methods are available to estimate TAI interval between injury and death. In this study, FTIR spectroscopy with infrared microscopy was applied to collect infrared spectra in the corpus callosum (CC) of rats subjected to TAI at 12, 24 and 72h post-injury versus control animals. The classification among different groups was visualized based on the acquired dataset using hierarchical cluster analysis (HCA) and partial least square (PLS)...
June 28, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28657644/communication-in-children-and-adolescents-after-acquired-brain-injury-an-exploratory-study
#17
Åsa Fyrberg, Göran Horneman, Jakob Åsberg Johnels, Gunilla Thunberg, Elisabeth Ahlsén
OBJECTIVE: The usability of the Communicative Effectiveness Index (CETI) in adolescents with acquired brain injury was investigated and compared with linguistic, cognitive and brain injury data. DESIGN: A prospective, longitudinal, between-group design. SUBJECTS: Thirty participants were divided into 2 subgroups: CETI+ and CETI- groups. METHODS: Parental CETI ratings of daily communication were compared with linguistic data and IQ test results...
June 28, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28651477/moderators-mediators-and-nonspecific-predictors-of-outcome-after-cognitive-rehabilitation-of-executive-functions-in-a-randomised-controlled-trial
#18
Sveinung Tornås, Jan Stubberud, Anne-Kristin Solbakk, Jonathan Evans, Anne-Kristine Schanke, Marianne Løvstad
Moderators, mediators and nonspecific predictors of treatment after cognitive rehabilitation of executive functions in a randomised controlled trial Objective: To explore moderators, mediators and nonspecific predictors of executive functioning after cognitive rehabilitation in a randomised controlled trial, comparing Goal Management Training (GMT) with an active psycho-educative control-intervention, in patients with chronic acquired brain injury. METHODS: Seventy patients with executive dysfunction were randomly allocated to GMT (n = 33) or control (n = 37)...
June 27, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28647441/prevention-of-epilepsy-should-we-be-avoiding-clinical-trials
#19
REVIEW
Pavel Klein, Ivana Tyrlikova
Epilepsy prevention is one of the great unmet needs in epilepsy. Approximately 15% of all epilepsy is caused by an acute acquired CNS insult such as traumatic brain injury (TBI), stroke or encephalitis. There is a latent period between the insult and epilepsy onset that presents an opportunity to intervene with preventive treatment that is unique in neurology. Yet no phase 3 epilepsy prevention studies, and only 2 phase 2 studies have been initiated in the last 16years. Current prevailing opinion is that the research community is not ready for clinical preventive epilepsy studies, and that animal models should first be refined and biomarkers of epileptogenesis and of epilepsy discovered before clinical studies are embarked upon...
June 21, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28641533/role-and-therapeutic-potential-of-astrocytes-in-amyotrophic-lateral-sclerosis
#20
Mariana Pehar, Benjamin A Harlan, Kelby M Killoy, Marcelo R Vargas
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. The molecular mechanism underlying the progressive degeneration of motor neuron remains uncertain but involves a non-cell autonomous process. In acute injury or degenerative diseases astrocytes adopt a reactive phenotype known as astrogliosis. Astrogliosis is a complex remodeling of astrocyte biology and most likely represents a continuum of potential phenotypes that affect neuronal function and survival in an injury-specific manner...
June 21, 2017: Current Pharmaceutical Design
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