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https://www.readbyqxmd.com/read/28539965/chemicals-compositions-antioxidant-and-anti-inflammatory-activity-of-cynara-scolymus-leaves-extracts-and-analysis-of-major-bioactive-polyphenols-by-hplc
#1
Maryem Ben Salem, Hanen Affes, Khaled Athmouni, Kamilia Ksouda, Raouia Dhouibi, Zouheir Sahnoun, Serria Hammami, Khaled Mounir Zeghal
Objective. Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care. The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC. Methods. Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test. The carrageenan (Carr) model induced paw oedema in order to investigate the anti-inflammatory activity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28527996/enzymatic-hydrolysis-of-pretreated-alfa-fibers-stipa-tenacissima-using-%C3%AE-d-glucosidase-and-xylanase-of-talaromyces-thermophilus-from-solid-state-fermentation
#2
Hanen Mallek-Fakhfakh, Jawhar Fakhfakh, Kamel Walha, Hajer Hassairi, Ali Gargouri, Hafedh Belghith
This work aims at realizing an optimal hydrolysis of pretreated Alfa fibers (Stipa tenacissima) through the use of enzymes produced from Talaromyces thermophilus AX4, namely β-D-glucosidase and xylanase, by a solid state fermentation process of an agro-industrial waste (wheat bran supplemented with lactose). The carbon source was firstly selected and the optimal values of three other parameters were determined: substrate loading (10g), moisture content (85%) and production time (10 days); which led to an optimized enzymatic juice...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28461019/polar-and-apolar-extra-virgin-olive-oil-and-leaf-extracts-as-a-promising-anti-inflammatory-natural-treatment-for-osteoarthritis
#3
Houda Nsir, Marta Anna Szychlinska, Venera Cardile, Adriana Carol Eleonora Graziano, Rosanna Avola, Hanen Esafi, Alessandra Bendini, Mokhtar Zarouk, Carla Loreto, Venerando Rapisarda, Paola Castrogiovanni, Giuseppe Musumeci
Osteoarthritis (OA) is a common joint disease with important socio-economic impact. Looking for a novel natural treatment represents an important challenge and a public health objective. A wide range of previous studies highlighted the antioxidant and anti-inflammatory properties especially of phenolic compounds present in olive oil. Therefore, the aim of this study was to investigate the anti-inflammatory activity of Tunisian Extra Virgin Olive Oil (EVOO) extracts in an in vitro OA model. To this aim we evaluated the polar and apolar olive oil fractions and olive leaf extract...
April 28, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28416298/-epicutaneous-patch-testing-in-delayed-drug-hypersensitivity-reactions-induced-by-antiepileptic-drugs
#4
Lobna Ben Mahmoud, Najla Bahloul, Hanen Ghozzi, Brahim Kammoun, Ahmed Hakim, Zouheir Sahnoun, Sami Kammoun, Khaled Zeghal
INTRODUCTION: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. METHODS: We analyzed all cases of allergic skin reactions to antiepileptic drugs notified in regional pharmacovigilance center of Sfax (Tunisia) between June 1, 2014 and April 30, 2016...
March 25, 2017: Thérapie
https://www.readbyqxmd.com/read/28401468/morphological-and-molecular-characterization-of-fusarium-spp-associated-with-olive-trees-dieback-in-tunisia
#5
Rahma Trabelsi, Hanen Sellami, Yâakoub Gharbi, Samira Krid, Manel Cheffi, Sonia Kammoun, Mariem Dammak, Aymen Mseddi, Radhouane Gdoura, Mohamed Ali Triki
Dieback and wilting symptoms caused by complex soilborne fungi are nowadays the most serious threatening disease affecting olive trees (Olea europaea) in Tunisia and presumably in many Mediterranean basin countries. Fusarium is one of the important phytopathogenic genera associated with dieback symptoms of olive trees. The objective of the present study was to confirm the pathogenicity of Fusarium spp. isolated from several olive-growing areas in Tunisia. According to the pathogenic test done on young olive trees (cv...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28385108/urtica-dioica-attenuates-ovalbumin-induced-inflammation-and-lipid-peroxidation-of-lung-tissues-in-rat-asthma-model
#6
Hanene Zemmouri, Omar Sekiou, Sonda Ammar, Abdelfattah El Feki, Mohamed Bouaziz, Mahfoud Messarah, Amel Boumendjel
CONTEXT: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use. OBJECTIVE: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract. MATERIALS AND METHODS: Adult male Wistar rats were divided into four groups: Group I: negative control; group II: Ovalbumin sensitized/challenged rats (positive control); group III: received UD extract (1...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28372462/polysaccharides-extraction-from-opuntia-stricta-and-their-protective-effect-against-hepg2-cell-death-and-hypolipidaemic-effects-on-hyperlipidaemia-rats-induced-by-high-fat-diet
#7
Bahira Harrabi, Khaled Athmouni, Latifa Hamdaoui, Lobna Ben Mahmoud, Ahmed Hakim, Abdelfattah El Feki, Khaled Zeghal, Hanéne Ghozzi
The aim of this study was to analyse cytoprotective effect of polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose was the dominant monosaccharides (30.35%). Arabinose, pyranose, fructose, galactose, glucose, sorbitol, S-inositol, M-inositol, trehalose and saccharose found in this species. O. stricta polysaccharides did not cause any cytotoxic effect on HepG2 cells within the range of concentrations tested (0-400 μgml(-1))...
April 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28363165/hepatoprotective-activity-of-rhus-oxyacantha-root-cortex-extract-against-ddt-induced-liver-injury-in-rats
#8
Hanène Ben Miled, Zaineb Ben Barka, Dorsaf Hallègue, Karima Lahbib, Mohamed Ladjimi, Mounira Tlili, Mohsen Sakly, Khémais Ben Rhouma, Riadh Ksouri, Olfa Tebourbi
The present investigation aimed to study the antioxidant activity and hepatoprotective effects of ethyl acetate extract of R. oxyacantha root cortex (RE) against DDT-induced liver injury in male rats. The RE exhibited high total phenolic, flavonoid and condensed tannins contents. The antioxidant activity in vitro systems showed a significant potent free radical scavenging activity of the extract. The HPLC finger print of R. oxyacantha active extract showed the presence of five phenolic compounds with higher amounts of catechol and gallic acid...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28306688/oxidative-stress-in-tunisian-patients-with-acute-lymphoblastic-leukemia-and-its-involvement-in-leukemic-relapse
#9
Lobna Ben Mahmoud, Moez Mdhaffar, Hanene Ghozzi, Mariam Ammar, Ahmed Hakim, Rim Atheymen, Zouheir Sahnoun, Moez Elloumi, Khaled Zeghal
The aim of the present study was to evaluate in patients with acute lymphoblastic leukemia (ALL), the oxidative status and antioxidant defense and its involvement in the relapse of ALL. The plasmatic levels of malondialdehyde, advanced oxidation of protein products and reduced glutathione (GSH), and the plasmatic activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase were determined in 34 patients who were newly diagnosed with ALL and compared with 92 healthy individuals. The plasmatic concentrations of malondialdehyde and advanced oxidation of protein products were higher in ALL patients than in controls and increased during chemotherapy...
April 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28296682/causes-and-characteristics-of-death-in-intensive-care-units-a-prospective-multicenter-study
#10
MULTICENTER STUDY
Jean-Christophe Orban, Yannick Walrave, Nicolas Mongardon, Bernard Allaouchiche, Laurent Argaud, Frédéric Aubrun, Geneviève Barjon, Jean-Michel Constantin, Gilles Dhonneur, Jacques Durand-Gasselin, Hervé Dupont, Michèle Genestal, Chloé Goguey, Philippe Goutorbe, Bertrand Guidet, Hervé Hyvernat, Samir Jaber, Jean-Yves Lefrant, Yannick Mallédant, Jerôme Morel, Alexandre Ouattara, Nicolas Pichon, Anne-Marie Guérin Robardey, Michel Sirodot, Alexandre Theissen, Sandrine Wiramus, Laurent Zieleskiewicz, Marc Leone, Carole Ichai
BACKGROUND: Different modes of death are described in selected populations, but few data report the characteristics of death in a general intensive care unit population. This study analyzed the causes and characteristics of death of critically ill patients and compared anticipated death patients to unexpected death counterparts. METHODS: An observational multicenter cohort study was performed in 96 intensive care units. During 1 yr, each intensive care unit was randomized to participate during a 1-month period...
May 2017: Anesthesiology
https://www.readbyqxmd.com/read/28286932/hoct1-gene-expression-predict-for-optimal-response-to-imatinib-in-tunisian-patients-with-chronic-myeloid-leukemia
#11
Islem Ben Hassine, Hanene Gharbi, Ismail Soltani, Mouheb Teber, Ahlem Farrah, Hind Ben Hadj Othman, Hassiba Amouri, Hatem Bellaaj, Rayhane Ben Lakhal, Neila Ben Romdhane, Salem Abbes, Samia Menif
PURPOSE: Imatinib mesylate (IM) is considered as a highly effective therapy for chronic myeloid leukemia (CML) patients. However, a minority of patients fail to achieve optimal response due to impaired bioavailability of IM. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in IM uptake into CML cells. Genetic variants and/or hOCT1 expression changes may influence IM response. In this study, we aimed to investigate the impact of both hOCT1 polymorphisms located in exon 7 and hOCT1 mRNA levels on the clinical outcome in CML patients...
March 12, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28278668/chemical-characterisation-and-biological-activity-of-leaf-essential-oils-obtained-from-pistacia-terebinthus-growing-wild-in-tunisia-and-sardinia-island
#12
Alessandra Piras, Hanen Marzouki, Andrea Maxia, Arianna Marengo, Silvia Porcedda, Danilo Falconieri, Maria José Gonçalves, Carlos Cavaleiro, Ligia Salgueiro
In the present work the chemical compositions, measured by GC and GC-MS, of the essential oils obtained by hydrodistillation from leaves of Pistacia terebinthus collected in Bizerte (Tunisia) and Baunei (Italy) are reported. Both essential oils possessed high content of monoterpene hydrocarbons (86.3% and 90.9%, respectively), being α-pinene (62.4 vs. 35.0)%, camphene (3.0 vs. 2.4)%, β-pinene (12.1 vs. 4.5)%, terpinolene (1.7 vs. 35.2)% and β-phellandrene (3.8 vs. 4.5)% the main components. The Tunisian essential oil exhibited higher antifungal activity than the Italian one...
February 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28260117/quantification-of-bacillus-thuringiensis-vip3aa16-entomopathogenic-toxin-using-its-hemolytic-activity
#13
Hanen Boukedi, Saoussen Ben Khedher, Dhouha Ghribi, Mariam Dammak, Slim Tounsi, Lobna Abdelkefi-Mesrati
Vegetative insecticidal proteins produced by some Bacillus thuringiensis strains are specifically toxic to different agricultural pests such as the polyphagous Spodoptera and several other Lepidopteran insects, but one of the major problems found in the use of these biopesticides was the lack of an easy and credible method of quantification of such secreted toxins. Heterologous expression of B. thuringiensis Vip3Aa16 toxin was performed in Escherichia coli then the protein was purified by chromatography. Using blood agar as well as blood agar overlay (zymogram assay), we reported, for the first time, the capacity of Vip3Aa16 to induce hemolysis...
May 2017: Current Microbiology
https://www.readbyqxmd.com/read/28223048/vegetative-insecticidal-protein-of-bacillus-thuringiensis-blb459-and-its-efficiency-against-lepidoptera
#14
Hanen Boukedi, Saoussen Ben Khedher, Rania Hadhri, Samir Jaoua, Slim Tounsi, Lobna Abdelkefi-Mesrati
Bacillus thuringiensis strain BLB459 supernatant showed a promising activity against Lepidopteran pests with extremely damages in the larvae midgut. Investigations of the genes that encode secreted toxin demonstrated that this strain harbored a vip3-type gene named vip3(459). Based on its original nucleotide and amino acid sequences, this gene was cloned into pET-14b vector and overexpressed in Escherichia coli. The expressed protein was purified and tested against different insects and interestingly the novel toxin demonstrated a remarkable activity against the stored products pest Ephestia kuehniella and the polyphagous insects Spodoptera littoralis and Agrotis segetum...
February 20, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28221954/molecular-detection-of-the-three-major-pathogenic-vibrio-species-from-seafood-products-and-sediments-in-tunisia-using-real-time-pcr
#15
Morsi Gdoura, Hanen Sellami, Hanen Nasfi, Rahma Trabelsi, Sabeur Mansour, Touraya Attia, Siwar Nsaibia, Tatiana Vallaeys, Radhouane Gdoura, Mariam Siala
Vibrio spp. have emerged as a serious threat to human health worldwide. V. parahaemolyticus , V. cholerae , and V. vulnificus pose a considerable public health risk in Tunisia because they cause sporadic and epidemic foodborne infections associated with the consumption of raw or undercooked contaminated seafood. More recently, toxR-positive V. alginolyticus was also reported to be a potential source of contaminated seafood. A total of 247 samples, including 113 fishes ( Labrus viridis , Penaeus kerathurus , Diplodus annularis , Diplodus sparaillon , Scorparna porcus , Sarpa salpa , Dentex dentex , Scorparna scrofa , Sardinella aurita , Trachurus trachurus , Synodus saurus , Pagellus erythrinus , and Metapenaeus monoceros ), 83 clams ( Ruditapes decussatus species), 30 seawater samples, and 21 sediment samples were analyzed using traditional culture methods (ISO/TS 21872-1; International Organization for Standardization 2007) and a conventional PCR method for Vibrio spp...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28213662/desulfobulbus-aggregans-sp-nov-a-novel-sulfate-reducing-bacterium-isolated-from-marine-sediment-from-the-gulf-of-gabes
#16
Hanen Kharrat, Fatma Karray, Manon Bartoli, Wajdi Ben Hnia, Najla Mhiri, Marie-Laure Fardeau, Feten Bennour, Lotfi Kamoun, Didier Alazard, Sami Sayadi
Three sulfate-reducing bacterial strains designated SM40(T), SM41, and SM43 were isolated from marine sediment in the region of Skhira located in the Gulf of Gabes (Tunisia). These strains grew in anaerobic media with phosphogypsum as a sulfate source and sodium lactate as an electron and carbon source. One of them, strain SM40(T), was characterized by phenotypic and phylogenetic methods. Cells were ovoid, Gram-stain-negative and non-motile. The temperature limits for growth were 10 and 55 °C with an optimum at 35 °C and the pH range was 6...
April 2017: Current Microbiology
https://www.readbyqxmd.com/read/28192053/ensuring-local-capacity-for-public-health-disaster-response-and-recovery-a-national-imperative
#17
Laura Hanen, Meghan McGinty
No abstract text is available yet for this article.
January 2017: Health Security
https://www.readbyqxmd.com/read/28188070/-inflammation-in-the-perivascular-adipose-tissue-and-atherosclerosis
#18
Nadjiba Hamlat-Khennaf, Samia Neggazi, Hanene Ayari, Patrick Feugier, Giampiero Bricca, Souhila Aouichat-Bouguerra, Michel Beylot
In atherosclerosis studies, there are few data, especially in men, on the biology of perivascular adipose tissue (PVAT) compared to that of other adipose tissue (AT), on amendments in obesity, and its possible role in the development of atherosclerosis. We conducted an ex vivo human study on pericarotid adipose tissue-collected in the immediate vicinity (PVATp) and away from the plate (tapas)-and subcutaneous (SC) neck gathered during surgery from patients suffering from atheromatous carotid disease. In addition, we conducted a study in obese Zucker rats (models of obesity and insulin resistance) and Wistar rats subjected to moderate stress...
February 7, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28167450/extraction-optimization-and-in-vitro-and-in-vivo-anti-postprandial-hyperglycemia-effects-of-inhibitor-from-phoenix-dactylifera-l-parthenocarpic-fruit
#19
Hanen El Abed, Mouna Chakroun, Imen Fendri, Mohamed Makni, Mohamed Bouaziz, Noureddine Drira, Hafedh Mejdoub, Bassem Khemakhem
Phoenix dactylifera L. plays an important role in social, economic, and ecological Tunisian sectors. Some date palms produce parthenocarpic fruit named Sish. The aqueous ethanolic extract from P. dactylifera parthenocarpic dates demonstrated a potent inhibition of the enzymes related to type II diabetes. In this work, extraction optimization of amylase inhibitors was carried out using Box-Behnken Design. Bioactivity-guided fractionation of the 70% aqueous ethanol extract was performed to identify the active compounds...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28130168/anaplasma-platys-like-strains-in-ruminants-from-tunisia
#20
Mourad Ben Said, Hanène Belkahia, Narjesse El Mabrouk, Mariem Saidani, Alberto Alberti, Rosanna Zobba, Amal Cherif, Tarek Mahjoub, Ali Bouattour, Lilia Messadi
Molecular diagnosis of Anaplasma platys and related strains (A. platys-like) in carnivores and ruminants is challenging due to co-infections with cross-reacting strains, and require post-amplification sequencing of the hemi-nested PCR products traditionally generated by targeting the groEL gene. In this study, a Restriction Enzyme Fragment Length Polymorphism (RFLP) assay coupled to hemi-nested groEL PCR was developed to discriminate among A. platys and genetically related strains. This novel approach was used for investigating A...
January 24, 2017: Infection, Genetics and Evolution
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