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Ahmed Amine Azzaz, Salah Jellali, Hanene Akrout, Aymen Amine Assadi, Latifa Bousselmi
The present study investigates the alkaline modification of raw orange tree sawdust (ROS) for an optimal removal of methylene blue (MB), as a cationic dye model, from synthetic solutions. The effects of operating parameters, namely, sodium hydroxide (NaOH) concentrations, ROS doses in NaOH solutions, stirring times, and initial MB concentrations on dye removal efficiency, were followed in batch mode. The process optimization was performed through the response surface methodology approach (RSM) by using Minitab17 software...
October 10, 2016: Environmental Science and Pollution Research International
Hanen Ouadani, Imen Ben-Mustapha, Meriem Ben-Ali, Beya Larguèche, Tihana Jovanic, Sylvie Garcia, Benoit Arcangioli, Houda Elloumi-Zghal, Dahmani Fathallah, Mongia Hachicha, Hatem Masmoudi, François Rougeon, Mohamed-Ridha Barbouche
Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper IgM 2 syndrome where both CSR and SHM or only CSR are affected. Indeed, triggering either of the two mechanisms requires the DNA deamination activity of AID. Besides, different domains of AID may be differentially involved in CSR and SHM through their interaction with specific cofactors...
October 4, 2016: Molecular Immunology
Mohamed Sellami, Hanen Louati, Jannet Kamoun, Ali Kchaou, Mohamed Damak, Youssef Gargouri
The aim of this study is to search new anti-obesity and anti-diabetic agents from plant and spices crude extracts as alternative to synthetic drugs. The inhibitory effect of 72 extracts was evaluated, in vitro, on lipase and amylase activities. Aqueous extracts of cinnamon and black tea exhibited an appreciable inhibitory effect on pancreatic amylase with IC50 values of 18 and 87 μg, respectively. Aqueous extracts of cinnamon and mint showed strong inhibitory effects against pancreatic lipase with IC50 of 45 and 62 μg, respectively...
October 6, 2016: International Journal of Food Sciences and Nutrition
Samia Hamouda, Karima Chraiet, Fatma Khalsi, Imen Bel Hadj, Ines Brini, Hanen Smaoui, Sihem Barsaoui, Azza Samoud, Saida Ben Becher, Najla Ben Jaballah, Amel Kechrid, Faten Tinsa, Khadija Boussetta
Background Community-acquired pleuropneumonia (CPP) is a common complication of pneumonia in children. It is serious given its high morbidity and significant mortality. Aim To study clinical and paraclinical features of CPP in children and to establish a common therapeutic strategy. Methods Our retrospective study included patients who were hospitalized for CPP between 2004 and 2012. All data were collected from patients' medical files. Statistical analysis was made by Epi-Info 6. Results One hundred and sixty four patients were registered...
April 2016: La Tunisie Médicale
Hanene Miladi, Hamouda Elabed, Rihab Ben Slama, Amel Rhim, Amina Bakhrouf
Listeria monocytogenes is a food-borne pathogen of humans and other animals. The striking ability to survive several stresses usually used for food preservation makes L. monocytogenes one of the biggest concerns to the food industry. This ubiquity can be partly explained by the ability of the organism to grow and persist at very low temperatures, a consequence of its ability to accumulate cryoprotective compound called osmolytes. A quantitative RT-PCR assay was used to measure mRNA transcript accumulation for the stress response genes opuCA and betL (encoding carnitine and betaine transporters, respectively) and the housekeeping gene 16S rRNA...
October 1, 2016: Archives of Microbiology
Rim Maaoui, Emna Bahlouli, Imen Ksibi, Hanen Khiari, Hajer Rahali
OBJECTIVE: Psychosocial factors appear increasingly decisive in functional disability related to chronic low-back pain. Catastrophizing and kinesiophobia lead to deconditioning and the perpetuation of pain. The purpose of this study is to evaluate fear, beliefs, catastrophizing and kinesiophobia in chronic low-back pain patients about to begin a training programme in a rehabilitation centre. MATERIAL/PATIENTS AND METHODS: Retrospective study conducted in the department of physical and rehabilitation medicine in the Military Tunis hospital between March and June 2015, concerning patients followed for chronic low-back pain...
September 2016: Annals of Physical and Rehabilitation Medicine
Mouna Chakroun, Bassem Khemakhem, Hazem Ben Mabrouk, Hanen El Abed, Mohamed Makni, Mohamed Bouaziz, Noureddine Drira, Naziha Marrakchi, Hafedh Mejdoub
Among various chronic disorders, cancer and diabetes mellitus are the most common disorders. This study was designed to evaluate the effectiveness of hydroalcoholic extract of Phoenix dactylifera L. leaves (HEPdL) in animal models of type II diabetes in vitro/in vivo and in a human melanoma-derived cell line (IGR-39). A liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was also performed to determine the amount of phenolic and flavonoid compounds in this plant. The physicochemical results by LC-MS/MS analysis of HEPdL showed the presence of 10 phenolic compounds...
September 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mariem Ben Jemaa, Hanen Falleh, Marcos A Neves, Hiroko Isoda, Mitsutoshi Nakajima, Riadh Ksouri
The objective of this study is to evaluate the effect of either a solution of Thymus capitatus essential oil or its nanoemulsion on the quality of milk contaminated by bacteria. After 24h of S. aureus inoculation, bacterial growth reached 202×10(3)CFU/ml in the presence of the essential oil while it was limited to 132×10(3)CFU/ml when treated with nanoemulsion. The reduction of antioxidant capacity of milk treated with essential oil was higher when treated with nanoemulsion. Moreover, free essential oil was more efficient in protecting proteins from degradation than the nanoemulsion...
February 15, 2017: Food Chemistry
Mourad Ben Said, Hanène Belkahia, Alberto Alberti, Khaoula Abdi, Manel Zhioua, Monia Daaloul-Jedidi, Lilia Messadi
Borrelia burgdorferi sensu lato (s.l.) are tick-transmitted spirochaetes of veterinary and human importance. Molecular epidemiology data on ruminants are still lacking in most countries of the world. Therefore, the aim of this study was to estimate the rate of B. burgdorferi s.l. infection in ruminants from Tunisia. A total of 1,021 ruminants (303 goats, 260 sheep, 232 cattle and 226 camels) from different bioclimatic areas in Tunisia were investigated for the presence of B. burgdorferi s.l. DNA in blood by real time PCR...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
Hanen Bouaziz, Ramzi Khiari, Mohamed Dridi, Samir Ghozzi, Nawfel Ben Rais
Epithelioid angiomyolipoma is a rare form of potentially malignant angiomyolipoma, recently considered separate entity by the World Health Organization classification of renal tumors. This lesion poses a problem in differential diagnosis with clear cell carcinomas. There are no clinical or radiological specific criteria that characterize this tumor. Immunohistochemistry revealing epithelioid cells with positive HMB45 marker is essential for diagnosis. Treatment should be discussed during the multidisciplinary consultation...
2016: Pan African Medical Journal
Ismael Soltani, Hanen Gharbi, Islem Ben Hassine, Ghada Bouguerra, Kais Douzi, Mouheb Teber, Salem Abbes, Samia Menif
Targeted therapy in the form of selective breakpoint cluster region-abelson (BCR/ABL) tyrosine kinase inhibitor (imatinib mesylate) has successfully been introduced in the treatment of the chronic myeloid leukemia (CML). However, acquired resistance against imatinib mesylate (IM) has been reported in nearly half of patients and has been recognized as major issue in clinical practice. Multiple resistance genes and microRNAs (miRNAs) are thought to be involved in the IM resistance process. These resistance genes and miRNAs tend to interact with each other through a regulatory network...
September 16, 2016: Functional & Integrative Genomics
Nawel Jemil, Hanen Ben Ayed, Noomen Hmidet, Moncef Nasri
Six biosurfactant-producing bacteria were isolated from hydrocarbon contaminated soils in Sfax, Tunisia. Isolates were screened for biosurfactant production by different conventional methods including hemolytic activity, surface tension reduction, drop-collapsing and oil displacement tests. All these screening tests show that all the isolates behave differently. Among the isolated bacteria, DCS1 strain was selected for further studies based on its highest activities and it was identified as Bacillus methylotrophicus DCS1...
November 2016: World Journal of Microbiology & Biotechnology
Mouna Ghazouani, Hanene Akrout, Latifa Bousselmi
This work investigated the electrochemical treatment of four real effluents which were municipal wastewater (MWW), human urine (HU), river water (Wadi), and slaughterhouse wastewater (SHWW). The treatment was performed on a Boron-Doped Diamond (BDD) as anode/cathode material with an applied current density of 35.7 mA cm(-2) and without any reagent addition. Effluent characterization before treatment indicated that nitrogen pollution existed essentially as ammonium/ammonia ions, low level of nitrate, and in some cases as nitrite form...
September 13, 2016: Environmental Science and Pollution Research International
Hela Ben Khelifa, Molka Kammoun, Hanene Hannachi, Najla Soyah, Saber Hammami, Hatem Elghezal, Damien Sanlaville, Ali Saad, Soumaya Mougou-Zerelli
We describe two patients carrying deletions of chromosome 8p23.1 with a commonly critical region identified by means of oligonucleotide array comparative genomic hybridization (array CGH). They didn't present congenital heart defects or behavioral problems. Only one patient presented with intellectual disability and carrying deletion of TNKS gene. We presumed the inclusion of TNKS gene in the mental impairment.
December 2015: Journal of Pediatric Genetics
Moez Kdous, Ghaya Merdassi, Fethi Zhioua, Hanène Elloumi, Khadija Kacem, Amel Zhioua
BACKGROUND: Age and increased FSH serum level in women are prognosis criteriae associated with decreased fertility. OBJECTIVE: The aim of this study was to investigate whether age-specific FSH concentration can be a predictor of the outcome of ovarian stimulation in women undergoing IVF. METHODS: A total of 676 women undergoing their first IVF cycle over a 3-year period were included in this retrospective cohort study. Patients were grouped according to age (< or ≥  38 years), and within each age range, patients were grouped into bFSH quartiles (< or ≥  9...
March 2016: La Tunisie Médicale
Afef Samet Ellouze, Rafik Bouaziz, Hanen Ghorbel
PURPOSE: Integrating semantic dimension into clinical archetypes is necessary once modeling medical records. First, it enables semantic interoperability and, it offers applying semantic activities on clinical data and provides a higher design quality of Electronic Medical Record (EMR) systems. However, to obtain these advantages, designers need to use archetypes that cover semantic features of clinical concepts involved in their specific applications. In fact, most of archetypes filed within open repositories are expressed in the Archetype Definition Language (ALD) which allows defining only the syntactic structure of clinical concepts weakening semantic activities on the EMR content in the semantic web environment...
August 24, 2016: Journal of Biomedical Informatics
Hanène Smadhi, Aymen Ayari, Héla Kammoun, Mohamed Sadok Boudaya, Aida Ayadi-Kaddour, Leila Fekih, Mohamed Lamine Megdiche
No abstract text is available yet for this article.
January 2016: La Tunisie Médicale
Hanene Miladi, Tarek Zmantar, Yassine Chaabouni, Kais Fedhila, Amina Bakhrouf, Kacem Mahdouani, Kamel Chaieb
In this study thymol (THY) and carvacrol (CAR), two monoterpenic phenol produced by various aromatic plants, was tested for their antibacterial and efflux pump inhibitors potencies against a panel of clinical and foodborne pathogenes. Our results demonstrated a substantial susceptibility of the tested bacteria toward THY and CAR. Especially, THY displayed a strong inhibitory activity (MIC's values ranged from 32 to 64 μg/mL) against the majority of the tested strains compared to CAR. Moreover, a significant reduction in MIC's of TET and benzalkonium chloride (QAC) were noticed when tested in combinations with THY and CAR...
October 2016: Microbial Pathogenesis
Zaineb Ben Barka, Chedia Aouadhi, Mounira Tlili, Hichem Alimi, Hanene Ben Miled, Khémais Ben Rhouma, Mohsen Sakly, Riadh Ksouri, Yves Jacques Schneider, Abderrazek Maaroufi, Olfa Tebourbi
INTRODUCTION: Rhus tripartita (Anacardiacae) is a plant which is traditionally used for the treatment of ulcer and diarrhea in Tunisia. However, the scientific basis for this usage has not been well established. The core aim of the present study is to evaluate the antidiarrheal activity of Rhus tripartita root methanolic extract (RRE). MATERIAL AND METHODS: The antidiarrheal activity of RRE oral doses (50, 100, 200 and 300mg/kg) was evaluated using the castor oil-induced diarrhea, the intestinal fluid emptying method and the normal intestinal transit test...
August 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ghayth Rigane, Hanene Ghazghazi, Chedia Aouadhi, Ridha Ben Salem, Zouheir Nasr
The aim of this study was to investigate the secondary metabolites related to Pistacia atlantica Desf as well as their biological activities. Results show that using ethanol as a solvent exhibited the highest content of total phenolics and flavonoids (68.23 mg GAE g(-1) of DW and 44 mg RE g(-1) of DW), followed by aqueous one (20.07 mg GAE g(-1) of DW and 15 mg RE g(-1) of DW). Good correlation (Data not shown) was obtained between the DPPH radical-scavenging activities and total phenolics contents...
August 3, 2016: Natural Product Research
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