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https://www.readbyqxmd.com/read/28317583/the-diagnostic-performance-of-18-f-fdg-pet-ct-ct-and-mri-in-the-treatment-evaluation-of-ablation-therapy-for-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#1
REVIEW
M Samim, I Q Molenaar, M F J Seesing, P S N van Rossum, M A A J van den Bosch, T J M Ruers, I H M Borel Rinkes, R van Hillegersberg, M G E H Lam, H M Verkooijen
PURPOSE: Uncertainty exists regarding the optimal imaging modality for timely detection of disease progression (DP) after ablation therapy for colorectal liver metastases. We evaluated the diagnostic accuracy of (18)F-FDG PET(/CT), CT and MRI for detection of DP following ablation therapy. METHODS: A systematic search was performed on May 18, 2016. The analysis included studies that reported on the diagnostic accuracy of (18)F-FDG PET(/CT), CT and/or MRI for post-ablative evaluation of patients with liver metastases...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28266145/safety-and-efficacy-of-microwave-ablation-for-medically-inoperable-colorectal-pulmonary-metastases-single-centre-experience
#2
Craig D Ferguson, Chris R Luis, Karin Steinke
INTRODUCTION: To evaluate the safety and therapeutic efficacy of percutaneous microwave ablation (MWA) for colorectal pulmonary metastases. METHODS: Retrospective review of CT-guided lung MWA at a single tertiary institution. Adverse events within 30 days of MWA were considered procedure-related complications. Imaging follow-up was with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and contrast-enhanced CT. Response of index tumours was assessed using modified response evaluation criteria in solid tumours (mRECIST)...
March 7, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28259750/long-term-outcomes-of-salvage-stereotactic-ablation-radiotherapy-for-isolated-lung-recurrence-of-non-small-cell-lung-cancer-a-phase-ii-clinical-trial
#3
Bing Sun, Eric D Brooks, Ritsuko Komaki, Zhongxing Liao, Melenda Jeter, Mary McAleer, Peter A Balter, James D Welsh, Michael O'Reilly, Daniel Gomez, Stephen M Hahn, Boris Sepesi, David C Rice, John V Heymach, Joe Y Chang
OBJECTIVES: Our goal was to evaluate stereotactic ablative radiotherapy (SABR) as a salvage option for isolated recurrence of non-small-cell lung cancer (NSCLC) in the lung parenchyma following definitive treatment of stage I-III disease. METHODS: Patients who had histologically confirmed, positron emission tomography (PET) staged, isolated NSCLC recurring locally or metastasis in the lung parenchyma (≤3 cm, suitable for SABR) after previous definitive treatment, were prospectively enrolled in this trial and treated with volumetric, image-guided SABR to 50 Gy in four fractions...
March 1, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28184942/radiological-biomarkers-for-assessing-response-to-locoregional-therapies-in-hepatocellular-carcinoma-from-morphological-to-functional-imaging-review
#4
Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28181822/oncogenic-osteomalacia-role-of-ga-68-dotanoc-pet-ct-scan-in-identifying-the-culprit-lesion-and-its-management
#5
Deepa Singh, Mudalsha Ravina, Narvesh Kumar, Veeresh Dube, Utham Kumar K, Manish Dixit, Sanjay Gambhir
OBJECTIVES: The aim of this study was to evaluate role of (68)Ga-DOTANOC PET/CT scan in localization of culprit lesion for biopsy and required intervention (surgical excision/radiofrequency ablation) in patients with long standing oncogenic osteomalacia (OOM)/tumor induced osteomalacia (TIO). METHODS: 17 patients (08 male & 09 female) underwent (68)Ga-DOTANOC PET/CT scan. The patients referred with clinical and biochemical evidence of hypophosphatemia and raised Fibroblast Growth Factor-23 (FGF-23)...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28180965/-18-f-fdg-pet-as-novel-imaging-biomarker-for-disease-progression-after-ablation-therapy-in-colorectal-liver-metastases
#6
M Samim, W Prevoo, B J de Wit-van der Veen, K F Kuhlmann, T Ruers, R van Hillegersberg, M A A J van den Bosch, H M Verkooijen, M G E H Lam, M P M Stokkel
PURPOSE: Recurrent disease following thermal ablation therapy is a frequently reported problem. Preoperative identification of patients with high risk of recurrent disease might enable individualized treatment based on patients' risk profile. The aim of the present work was to investigate the role of metabolic parameters derived from the pre-ablation (18)F-FDG PET/CT as imaging biomarkers for recurrent disease in patients with colorectal liver metastases (CLM). METHODS: Included in this retrospective study were all consecutive patients with CLM treated with percutaneous or open thermal ablation therapy who had a pre-treatment baseline (18)F-FDG PET/CT available...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28134698/68ga-exendin-4-pet-ct-in-evaluation-of-endoscopic-ultrasound-guided-ethanol-ablation-of-an-insulinoma
#7
Yaping Luo, Ji Li, Aiming Yang, Hongbo Yang, Fang Li
A 32-year-old man with endogenous hyperinsulinemic hypoglycemia was clinically diagnosed with an insulinoma. Conventional imaging result was negative, and a previous exploratory laparotomy with distal pancreatectomy failed to detect the tumor. Ga-exendin-4 PET/CT showed a lesion with intense radioactivity in the head of the pancreas suggestive of an insulinoma, and endoscopic ultrasound-guided ethanol ablation was performed. Postablation evaluation with Ga-exendin-4 PET/CT showed markedly decreased radioactivity of the tumor...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28129789/short-report-interim-safety-results-for-a-phase-ii-trial-measuring-the-integration-of-stereotactic-ablative-radiotherapy-sabr-plus-surgery-for-early-stage-non-small-cell-lung-cancer-missile-nsclc
#8
David A Palma, Timothy K Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V Louie, Eric Frechette, George B Rodrigues, Brian Yaremko, Edward Yu, A Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner, Aaron Ward, Richard Inculet
A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We report a mandated interim safety analysis for the first 10 patients who completed protocol treatment. Operable patients with biopsy-proven T1-2 N0 NSCLC were eligible. SABR was delivered using a risk-adapted fractionation (54Gy/3 fractions, 55/5 or 60/8). Surgical resection was planned 10 weeks later at a high-volume center (>200 lung cancer resections annually)...
January 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28126325/stereotactic-ablative-radiation-therapy-for-lung-oligometastases-predictive-parameters-of-early-response-by-18-fdg-pet-ct
#9
Rosario Mazzola, Alba Fiorentino, Gioacchino Di Paola, Niccolò Giaj Levra, Francesco Ricchetti, Sergio Fersino, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVES: The objective of this study was to investigate fludeoxyglucose F 18 positron emission tomography/computed tomography ((18)FDG-PET/CT) parameters as predictive of response after stereotactic ablative radiotherapy (SABR) for lung oligometastases. METHODS: The inclusion criteria of the current retrospective study were as follows: (1) lung oligometastases treated by SABR, (2) presence of (18)FDG-PET/CT before and after SABR for at least two subsequent evaluations, (3) Karnofsky performance status higher than 80, and (4) life expectancy longer than 6 months...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28116853/utility-of-68-ga-prostate-specific-membrane-antigen-positron-emission-tomography-in-diagnosis-and-response-assessment-of-recurrent-renal-cell-carcinoma
#10
Shankar Siva, Jason Callahan, David Pryor, Jarad Martin, Nathan Lawrentschuk, Michael S Hofman
INTRODUCTION: Prostate specific membrane antigen (PSMA) positron emission tomography (PET) is an emerging imaging modality in prostate cancer. However, (68) Ga-PSMA-PET may also have diagnostic utility in the setting of renal cell carcinoma (RCC). We investigate the differential role of (18) F-fluorodeoxyglucose (FDG) and PSMA-PET/CT scanning in patients with oligometastatic RCC. In particular, we focus on the utility of PSMA-PET for diagnostic evaluation of isolated or limited metastases planned for local surgery or radiation, as well as the potential utility of PSMA-PET for therapeutic response assessment in patients receiving stereotactic ablative body radiotherapy (SABR)...
January 24, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28052582/magnetically-driven-nanoparticles-18-fdg-radiolabelling-and-positron-emission-tomography-biodistribution-study
#11
Mariarosaria De Simone, Daniele Panetta, Emilia Bramanti, Cristiana Giordano, Maria C Salvatici, Lisa Gherardini, Arianna Menciassi, Silvia Burchielli, Caterina Cinti, Piero A Salvadori
Superparamagnetic iron oxide nanoparticles (SPIONs) have received increasing interest as contrast media in biomedical imaging and innovative therapeutic tools, in particular for loco-regional ablative treatments and drug delivery. The future of therapeutic applications would strongly benefit from improving the capability of the nanostructured constructs to reach the selected target, in particular beyond the intravascular space. Besides the decoration of SPIONs surface with ad hoc bioactive molecules, external magnetic fields are in principle able to remotely influence SPIONs' physiological biodistribution and concentrate them to a specific anatomical region or portion of a tissue...
November 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28027732/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-nodal-staging-of-stereotactic-ablative-body%C3%A2-radiotherapy-patients
#12
Macarena R Vial, Kashif A Khan, Oisin O'Connell, S Andrew Peng, Daniel R Gomez, Joe Y Chang, David C Rice, Reza Mehran, Carlos J Jimenez, Horiana B Grosu, David E Ost, George A Eapen
BACKGROUND: Patients with non-small cell lung cancer (NSCLC) being evaluated for stereotactic ablative body radiotherapy (SABR) are typically staged noninvasively with positron emission tomography/computed tomography (PET/CT). Incorporating endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) into the staging workup of these patients has not been evaluated. Our primary objective was to compare the performance of PET/CT with EBUS-TBNA for intrathoracic nodal assessment among SABR-eligible patients...
December 24, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27957721/computational-simulation-of-the-predicted-dosimetric-impact-of-adjuvant-yttrium-90-pet-ct-guided-percutaneous-ablation-following-radioembolization
#13
Alexander S Pasciak, Abigail Lin, Christos Georgiades, Laura K Findeiss, Shannon Kauffman, Yong C Bradley
BACKGROUND: (90)Y PET/CT post-radioembolization imaging has demonstrated that the distribution of (90)Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact of post-treatment (90)Y PET/CT-guided percutaneous ablation of the portions of a tumor receiving the lowest absorbed dose. A cohort of fourteen patients with non-resectable liver cancer previously treated using (90)Y radioembolization were included in this retrospective study. Each patient exhibited potentially under-treated areas of tumor following treatment based on quantitative (90)Y PET/CT...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27928604/-surgery-of-colorectal-lung-metastases-results-of-a-survey-in-germany
#14
W Dudek, W Schreiner, P Stapel, N Vassos, R Grützmann, H Sirbu
BACKGROUND: There is no evidence from randomized trials on the prognostic significance of pulmonary metastasectomy of colorectal cancer. The objective of this study was to assess the current criteria for indications, preoperative diagnostics and preferred operative techniques of pulmonary metastasectomy in Germany. METHODS: An anonymous survey was carried out in 239 German centers performing thoracic surgery in October 2015. RESULTS: Chest computed tomography (CT, 98%), liver CT (62%), pelvis CT (39%) and fluorodeoxyglucose positron emission tomography (FDG-PET, 37%) were used by the respondents (65% of participants) for preoperative staging...
December 7, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#15
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27889091/breath-hold-pet-ct-guided-tumour-ablation-under-general-anaesthesia-accuracy-of-tumour-image-registration-and-projected-ablation-zone-overlap
#16
P B Shyn, S Tremblay-Paquet, K Palmer, S Tatli, K Tuncali, O I Olubiyi, N Hata, S G Silverman
AIM: To assess single-breath-hold combined positron-emission tomography/computed tomography (PET/CT) for accuracy of tumour image registration and projected ablation volume overlap in patients undergoing percutaneous PET/CT-guided tumour-ablation procedures under general anaesthesia. MATERIALS AND METHODS: Eight patients underwent 12 PET/CT-guided tumour-ablation procedures to treat 20 tumours in the lung, liver, or adrenal gland. Using breath-hold PET/CT, the centre of the tumour was marked on each PET and CT acquisition by four readers to assess two- (2D) and three-dimensional (3D) spatial misregistration...
March 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27824968/an-intrapericardial-ectopic-thyroid-mimicking-metastasis-in-a-patient-with-papillary-thyroid-cancer-localization-differential-diagnosis-by-18-f-fdg-pet-ct-and-ablation-by-131-i
#17
Seol Hoon Park, Minjung Seo, Tae Young Park, Seong Nam-Goong
We report a very rare case of incidental intrapericardial thyroid in a papillary thyroid cancer patient. Post ablation scan revealed iodine-131 ((131)I) uptake in the mid-chest. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed and showed a (18)F-FDG avid lesion between the right atrium and the ascending aorta, (which was) shown to be an ectopic thyroid and not metastasis. The lesion disappeared on a 6 month follow-up (123)I whole body scan while serum thyroglobulin was negative...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27824959/risk-factors-and-stratification-for-recurrence-of-patients-with-differentiated-thyroid-cancer-elevated-thyroglobulin-and-negative-i-131-whole-body-scan-by-restaging-18-f-fdg-pet-ct
#18
Kursat Okuyucu, Semra Ince, Engin Alagoz, Ozdes Emer, Huseyin San, Elif Balkan, Aslı Ayan, Coskun Meric, Cem Haymana, Cengizhan Acıkel, Bengul Gunalp, Alper Ozgur Karacalioglu, Nuri Arslan
OBJECTIVE: In nearly 20%-30% of patients with differentiated thyroid carcinoma (DTC) relapse and 7% of them die during the next 10 years after initial diagnosis. In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 ((131)I) whole-body screening test ((131)I WBS) and increased serum thyroglobulin (Tg) level. Loss of ability of DTC metastatic lesions to trap (131)I is associated with pure survival and often aggressive disease. Several studies have shown that in DTC cases non trapping (131)I, fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) can detect recurrence or metastases with high sensitivity (80%-90%)...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27796820/whole-body-diffusion-weighted-magnetic-resonance-imaging-wb-dw-mri-vs-choline-positron-emission-tomography-computed-tomography-choline-pet-ct-for-selecting-treatments-in-recurrent-prostate-cancer
#19
A J Conde-Moreno, G Herrando-Parreño, R Muelas-Soria, J Ferrer-Rebolleda, R Broseta-Torres, M P Cozar-Santiago, F García-Piñón, C Ferrer-Albiach
OBJECTIVE: To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated...
October 31, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27716240/salvage-surgery-for-local-failures-after-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#20
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
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