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pet-ct ablation

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https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#1
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27889091/breath-hold-pet-ct-guided-tumour-ablation-under-general-anaesthesia-accuracy-of-tumour-image-registration-and-projected-ablation-zone-overlap
#2
P B Shyn, S Tremblay-Paquet, K Palmer, S Tatli, K Tuncali, O I Olubiyi, N Hata, S G Silverman
AIM: To assess single-breath-hold combined positron-emission tomography/computed tomography (PET/CT) for accuracy of tumour image registration and projected ablation volume overlap in patients undergoing percutaneous PET/CT-guided tumour-ablation procedures under general anaesthesia. MATERIALS AND METHODS: Eight patients underwent 12 PET/CT-guided tumour-ablation procedures to treat 20 tumours in the lung, liver, or adrenal gland. Using breath-hold PET/CT, the centre of the tumour was marked on each PET and CT acquisition by four readers to assess two- (2D) and three-dimensional (3D) spatial misregistration...
November 23, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27824968/an-intrapericardial-ectopic-thyroid-mimicking-metastasis-in-a-patient-with-papillary-thyroid-cancer-localization-differential-diagnosis-by-18-f-fdg-pet-ct-and-ablation-by-131-i
#3
Seol Hoon Park, Minjung Seo, Tae Young Park, Seong Nam-Goong
We report a very rare case of incidental intrapericardial thyroid in a papillary thyroid cancer patient. Post ablation scan revealed iodine-131 ((131)I) uptake in the mid-chest. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed and showed a (18)F-FDG avid lesion between the right atrium and the ascending aorta, (which was) shown tube an ectopic thyroid and not metastasis. The lesion disappeared on a 6 month follow-up (123)I whole body scan while serum thyroglobulin was negative...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27824959/risk-factors-and-stratification-for-recurrence-of-patients-with-differentiated-thyroid-cancer-elevated-thyroglobulin-and-negative-i-131-whole-body-scan-by-restaging-18-f-fdg-pet-ct
#4
Kursat Okuyucu, Semra Ince, Engin Alagoz, Ozdes Emer, Huseyin San, Elif Balkan, Aslı Ayan, Coskun Meric, Cem Haymana, Cengizhan Acıkel, Bengul Gunalp, Alper Ozgur Karacalioglu, Nuri Arslan
OBJECTIVE: In nearly 20%-30% of patients with differentiated thyroid carcinoma (DTC) relapse and 7% of them die during the next 10 years after initial diagnosis. In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 ((131)I) whole-body screening test ((131)I WBS) and increased serum thyroglobulin (Tg) level. Loss of ability of DTC metastatic lesions to trap (131)I is associated with pure survival and often aggressive disease. Several studies have shown that in DTC cases non trapping (131)I, fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) can detect recurrence or metastases with high sensitivity (80%-90%)...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27796820/whole-body-diffusion-weighted-magnetic-resonance-imaging-wb-dw-mri-vs-choline-positron-emission-tomography-computed-tomography-choline-pet-ct-for-selecting-treatments-in-recurrent-prostate-cancer
#5
A J Conde-Moreno, G Herrando-Parreño, R Muelas-Soria, J Ferrer-Rebolleda, R Broseta-Torres, M P Cozar-Santiago, F García-Piñón, C Ferrer-Albiach
OBJECTIVE: To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated...
October 31, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27716240/salvage-surgery-for-local-failures-after-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#6
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27665481/clinical-staging-of-stage-i-non-small-cell-lung-cancer-in-the-netherlands-need-for-improvement-in-an-era-with-expanding-nonsurgical-treatment-options-data-from-the-dutch-lung-surgery-audit
#7
David Jonathan Heineman, Martijn Geert Ten Berge, Johannes Marlene Daniels, Michaël Ignatius Versteegh, Perla Jacqueline Marang-van de Mheen, Michael Wilhelmus Wouters, Wilhelmina Hendrika Schreurs
BACKGROUND: The clinical stage of non-small cell lung cancer (NSCLC) determines the initial treatment, whereas the pathologic stage best determines prognosis and the need for adjuvant treatment. In an era in which stereotactic ablative radiotherapy (SABR) has become an alternative modality to surgical intervention, clinical staging is even more important, because pathologic staging is omitted in the case of SABR. The objective of this study was to determine the concordance between clinical and pathologic stage in routine clinical practice for patients with early-stage NSCLC...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27647003/rapid-virological-response-after-early-treatment-with-a-combined-therapy-of-ledipasvir-and-sofosbuvir-in-hcv-genotype-4-after-living-donor-liver-transplantation-in-a-hcc-downstaged-patient-case-report-and-review-of-the-literature
#8
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND Hepatitis C virus (HCV) genotype 4 (GT-4) is widespread in the Middle East, where it is responsible for the majority of HCV infections. It shows moderate treatment response rates when compared to other genotypes in the current era of interferon-based regimens. However, in the era of direct acting antiviral (DAA) drugs, its response is at least as good as observed for HCV genotypes 1-3. CASE REPORT We present a case of a 44-year-old patient with HCV cirrhosis. Since 2007, he has been treated for HCV infection with multiple ineffective regimens of interferon (INF) and ribavirin...
September 20, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27567554/imaging-after-radiation-therapy-of-thoracic-tumors
#9
B Ghaye, M Wanet, M El Hajjam
Radiation-induced lung disease (RILD) is frequent after therapeutic irradiation of thoracic malignancies. Many technique-, treatment-, tumor- and patient-related factors influence the degree of injury sustained by the lung after irradiation. Based on the time interval after the completion of the treatment RILD presents as early and late features characterized by inflammatory and fibrotic changes, respectively. They are usually confined to the radiation port. Though the typical pattern of RILD is easily recognized after conventional two-dimensional radiation therapy (RT), RILD may present with atypical patterns after more recent types of three- or four-dimensional RT treatment...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27501796/23-lung-metastases-treated-by-radiofrequency-ablation-over-10%C3%A2-years-in-a-single-patient-successful-oncological-outcome-of-a-metastatic-cancer-without-altered-respiratory-function
#10
Amandine Crombé, Xavier Buy, Yann Godbert, Nicolas Alberti, Michèle Kind, Françoise Bonichon, Jean Palussière
An 82-year-old man, who was diagnosed in 2002 with an oncocytic (Hürthle cell) thyroid carcinoma, was initially treated by local surgery and was refractory to radioiodine treatment. The patient had successive secondary recurrences from 2006 onwards. Metastases were suspected due to an elevation of thyroglobulin in serum. Hypermetabolic nodules were targeted using FDG PET as well as CT-guided radiofrequency ablations. Thyroglobulin levels decreased following each procedure. 10 years later, tolerance and efficacy are excellent; 23 lung metastases have been treated during 11 sessions without current relapse...
August 8, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27405041/brain-only-metastases-seen-on-fdg-pet-as-first-relapse-of-papillary-thyroid-carcinoma-two-years-post-thyroidectomy
#11
Sleiman Y Naddaf, Ghulam Mustafa Shah Syed, Abdulrahman Hadb, Saif Al-Thaqfi
We report a case of a 60-year-old man diagnosed with papillary thyroid cancer who had a relapse seen only in the brain at FDG PET on standard images. Total thyroidectomy was performed in July 2013 after initial diagnosis. Patient received I ablation in December 2013, followed by external beam radiotherapy to the neck. In September 2015, the patient presented with neurological symptoms. Brain MRI showed multiple brain metastases later confirmed on histopathology. An FDG PET/CT scan was performed to evaluate the whole body in November 2015...
September 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27347765/hepatocellular-carcinoma-intra-arterial-delivery-of-doxorubicin-loaded-hollow-gold-nanospheres-for-photothermal-ablation-chemoembolization-therapy-in-rats
#12
Junjie Li, Min Zhou, Fengyong Liu, Chiyi Xiong, Wanqin Wang, Qizhen Cao, Xiaoxia Wen, J David Robertson, Xin Ji, Y Andrew Wang, Sanjay Gupta, Chun Li
Purpose To determine if combretastatin A-4 phosphate disodium (CA4P) can enhance the tumor uptake of doxorubicin (Dox)-loaded, polyethylene glycol (PEG)-coated hollow gold nanospheres (HAuNS) mixed with ethiodized oil for improved photothermal ablation (PTA)-chemoembolization therapy (CET) of hepatocellular carcinoma (HCC) in rats. Materials and Methods Animal experiments were approved by the institutional animal care and use committee and performed from February 2014 to April 2015. Male Sprague-Dawley rats (n = 45; age, 12 weeks) were inoculated with N1S1 HCC cells in the liver, and 8 days later, were randomly divided into two groups of 10 rats...
November 2016: Radiology
https://www.readbyqxmd.com/read/27305763/imaging-intratumoral-nanoparticle-uptake-after-combining-nanoembolization-with-various-ablative-therapies-in-hepatic-vx2-rabbit-tumors
#13
Alda L Tam, Marites P Melancon, Mohamed Abdelsalam, Tomas Appleton Figueira, Katherine Dixon, Amanda McWatters, Min Zhou, Qian Huang, Osama Mawlawi, Kenneth Dunner, Chun Li, Sanjay Gupta
Combining image-guided therapy techniques for the treatment of liver cancers is a strategy that is being used to improve local tumor control rates. Here, we evaluate the intratumoral uptake of nanoparticles used in combination with radiofrequency ablation (RFA), irreversible electroporation (IRE), or laser induced thermal therapy (LITT). Eight rabbits with VX2 tumor in the liver underwent one of four treatments: (i) nanoembolization (NE) with radiolabeled, hollow gold nanoparticles loaded with doxorubicin (⁶⁴Cu-PEG-HAuNS-DOX); (ii) NE + RFA; (iii) NE + IRE; (iv) NE +LITT...
February 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27279087/undetected-lymph-node-metastases-in-presumed-early-stage-nsclc-sabr-patients
#14
Alberto Cerra-Franco, Khalil Diab, Tim Lautenschlaeger
INTRODUCTION: Stereotactic body radiation therapy (SBRT, also called stereotactic ablative body radiation SABR) is the treatment of choice for many patients with early-stage non-small cell lung cancer (NSCLC), including those who are unfit for surgery or refuse surgery. AREAS COVERED: In an effort to develop optimal staging for the evaluation of SBRT candidates, we review the performance of available lymph node staging methods, as well as risk factors for lymph node involvement...
August 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27272711/percutaneous-image-guided-cryoablation-of-challenging-mediastinal-lesions-using-large-volume-hydrodissection-technical-considerations-and-outcomes
#15
Julien Garnon, Guillaume Koch, Jean Caudrelier, Nitin Ramamurthy, Pramod Rao, Georgia Tsoumakidou, Roberto Luigi Cazzato, Afshin Gangi
OBJECTIVE: This study was designed to describe the technique of percutaneous image-guided cryoablation with large-volume hydrodissection for the treatment of challenging mediastinal lesions. METHODS: Between March 2014 and June 2015, three patients (mean age 62.7 years) with four neoplastic anterior mediastinal lesions underwent five cryoablation procedures using large-volume hydrodissection. Procedures were performed under general anaesthesia using CT guidance...
June 6, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27260478/percutaneous-radiofrequency-ablation-for-patients-with-malignant-lung-tumors-a-phase-ii-prospective-multicenter-study-jivrosg-0702
#16
Hideo Gobara, Yasuaki Arai, Takeshi Kobayashi, Koichiro Yamakado, Yoshitaka Inaba, Yoshihisa Kodama, Takuji Yamagami, Miyuki Sone, Hirokazu Watanabe, Yoshihiro Okumura, Takayoshi Shinya, Hiroaki Kurihara, Susumu Kanazawa
PURPOSE: This prospective multicenter study aimed to evaluate the efficacy and safety of percutaneous radiofrequency (RF) ablation for lung cancer. MATERIALS AND METHODS: From May 2008 to April 2012, 33 patients (26 men, 7 women; mean age 70.5 years) were enrolled. RF ablation was performed using an internally cooled or expandable multitined electrode. The primary endpoint was complete response (CR) determined using (18)F fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) performed 6 months after RF ablation...
August 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27249693/approach-to-oligometastatic-prostate-cancer
#17
Brandon Bernard, Boris Gershman, R Jeffrey Karnes, Christopher J Sweeney, Neha Vapiwala
Oligometastatic prostate cancer has increasingly been recognized as a unique clinical state with therapeutic implications. It has been proposed that patients with oligometastases may have a more indolent course and that outcome may be further improved with metastasis-directed local ablative therapy. In addition, there are differing schools of thoughts regarding whether oligometastases represent isolated lesions-where targeted therapy may render a patient disease free-or whether they coexist with micrometastases, where targeted therapy in addition to systemic therapy is required for maximal clinical impact...
2016: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/27245137/pulmonary-imaging-after-stereotactic-radiotherapy-does-recist-still-apply
#18
Sarah A Mattonen, Aaron D Ward, David A Palma
The use of stereotactic ablative radiotherapy (SABR) for the treatment of primary lung cancer and metastatic disease is rapidly increasing. However, the presence of benign fibrotic changes on CT imaging makes response assessment following SABR a challenge, as these changes develop with an appearance similar to tumour recurrence. Misclassification of benign fibrosis as local recurrence has resulted in unnecessary interventions, including biopsy and surgical resection. Response evaluation criteria in solid tumours (RECIST) are widely used as a universal set of guidelines to assess tumour response following treatment...
September 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27220509/radiofrequency-ablation-to-improve-survival-after-conversion-chemotherapy-for-colorectal-liver-metastases
#19
Karin Nielsen, Hester J Scheffer, José H Volders, Maurice J D L van der Vorst, Aukje A J M van Tilborg, Emile Fi Comans, E S M de Lange-de Klerk, Colin Sietses, Sybren Meijer, Martijn R Meijerink, M Petrousjka van den Tol
INTRODUCTION: Systemic chemotherapy is able to convert colorectal liver metastases (CRLM) that are initially unsuitable for local treatment into locally treatable disease. Surgical resection further improves survival in these patients. Our aim was to evaluate disease-free survival (DFS), overall survival, and morbidity for patients with CRLM treated with RFA following effective downstaging by chemotherapy, and to identify factors associated with recurrence and survival. MATERIALS AND METHODS: Included patients had liver-dominant CRLM initially unsuitable for local treatment but eligible for RFA or RFA with resection after downstaging by systemic chemotherapy...
August 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27167915/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-associazione-medici-endocrinologi-medical-guidelines-for-clinical-practice-for-the-diagnosis-and-management-of-thyroid-nodules-2016-update
#20
Hossein Gharib, Enrico Papini, Jeffrey R Garber, Daniel S Duick, R Mack Harrell, Laszlo Hegedüs, Ralf Paschke, Roberto Valcavi, Paolo Vitti
Thyroid nodules are detected in up to 50 to 60% of healthy subjects. Most nodules do not cause clinically significant symptoms, and as a result, the main challenge in their management is to rule out malignancy, with ultrasonography (US) and fine-needle aspiration (FNA) biopsy serving as diagnostic cornerstones. The key issues discussed in these guidelines are as follows: (1) US-based categorization of the malignancy risk and indications for US-guided FNA (henceforth, FNA), (2) cytologic classification of FNA samples, (3) the roles of immunocytochemistry and molecular testing applied to thyroid FNA, (4) therapeutic options, and (5) follow-up strategy...
May 2016: Endocrine Practice
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