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https://www.readbyqxmd.com/read/28429512/tailored-approach-for-management-of-ventricular-tachycardia-in-cardiac-sarcoidosis
#1
Sachin Yalagudri, Ngwe Zin Thu, Soumen Devidutta, Daljeet Saggu, Ajit Thachil, Sridevi Chennapragada, Calambur Narasimhan
INTRODUCTION: Treating ventricular tachycardia (VT) in patients with cardiac sarcoidosis (CS) is challenging as patients present in different phase of the disease (inflammatory, scar or sometimes both). A customized approach to treatment is required for better outcomes. We describe our experience in the management of VT in CS based on the phase of the disease. METHODS AND RESULTS: Patients were considered to have myocardial inflammation if there was an increased myocardial (18) Fluoro Deoxy Glucose (FDG) uptake in PET-CT scan of the chest (n=14)...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28391424/optimal-radiation-therapy-for-small-cell-lung-cancer
#2
REVIEW
Michael F Gensheimer, Billy W Loo
Radiation therapy plays an important role in the management of both limited stage and extensive stage small cell lung cancer. For limited stage disease, there has been a trend toward reduced size of thoracic radiation fields, which has the potential to reduce toxicity. FDG-PET staging helps make this possible by more accurately identifying areas of nodal and metastatic involvement. Trials have demonstrated similar outcomes using a range of radiation fractionation schedules, allowing flexibility in individualizing treatment...
April 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28385727/multicenter-clinical-and-imaging-evaluation-of-targeted-radiofrequency-ablation-t-rfa-and-cement-augmentation-of-neoplastic-vertebral-lesions
#3
Melinda Reyes, Mark Georgy, Lorenzo Brook, Orlando Ortiz, Allan Brook, Vikas Agarwal, Mario Muto, Luigi Manfre, Stefano Marcia, Bassem A Georgy
BACKGROUND: Treatment of spinal metastatic lesions by radiofrequency ablation (RFA) before cementation can potentially help in local tumor control and pain relief. This is often limited by access and tumor location. This study reports multicenter clinical and imaging outcomes following targeted RFA (t-RFA) and cement augmentation in neoplastic lesions of the spine. MATERIAL AND METHODS: A retrospective multicenter study of 49 patients with 72 painful vertebral lesions, evaluated for clinical and imaging outcomes following RFA and cement augmentation of spinal metastatic lesions, was undertaken...
April 6, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28380420/imaging-and-targeted-therapy-of-pancreatic-ductal-adenocarcinoma-using-the-theranostic-sodium-iodide-symporter-nis-gene
#4
Kathrin A Schmohl, Aayush Gupta, Geoffrey K Grünwald, Marija Trajkovic-Arsic, Kathrin Klutz, Rickmer Braren, Markus Schwaiger, Peter J Nelson, Manfred Ogris, Ernst Wagner, Jens T Siveke, Christine Spitzweg
The theranostic sodium iodide symporter (NIS) gene allows detailed molecular imaging of transgene expression and application of therapeutic radionuclides. As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. PDAC was induced in mice by pancreas-specific activation of constitutively active KrasG12D and deletion of Trp53...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28346656/7-year-follow-up-after-stereotactic-ablative-radiotherapy-for-patients-with-stage-i-non-small-cell-lung-cancer-results-of-a-phase-2-clinical-trial
#5
Bing Sun, Eric D Brooks, Ritsuko U Komaki, Zhongxing Liao, Melenda D Jeter, Mary F McAleer, Pamela K Allen, Peter A Balter, James D Welsh, Michael S O'Reilly, Daniel Gomez, Stephen M Hahn, Jack A Roth, Reza J Mehran, John V Heymach, Joe Y Chang
BACKGROUND: The authors evaluated the efficacy, patterns of failure, and toxicity of stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical stage I non-small cell lung cancer (NSCLC) in a prospective clinical trial with 7 years of follow-up. Clinical staging was performed according to the seventh edition of the American Joint Committee on Cancer TNM staging system. METHODS: Eligible patients with histologically confirmed NSCLC of clinical stage I as determined using positron emission tomography staging were treated with SABR (50 grays in 4 fractions)...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28333548/utility-of-pet-ct-after-cryoablation-for-early-identification-of-local-tumor-progression-in-osseous-metastatic-disease
#6
Ann T Packard, Stephen M Broski, Matthew R Callstrom, Thomas D Atwell, Grant D Schmit, John J Schmitz, Jonathan M Morris, Christopher H Hunt, A Nicholas Kurup
OBJECTIVE: The purpose of this study is to evaluate the utility of combined PET/CT for the detection of early local tumor progression after cryoablation of bone metastases. MATERIALS AND METHODS: A retrospective single-institution review revealed 61 consecutive patients with 80 separate bone metastases treated with cryoablation who were evaluated with a preablation PET/CT and at least two postablation PET/CT examinations between September 2007 and July 2015. Patients were excluded if they had local therapy or pathologic fracture after ablation...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28317583/the-diagnostic-performance-of-18-f-fdg-pet-ct-ct-and-mri-in-the-treatment-evaluation-of-ablation-therapy-for-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#7
REVIEW
M Samim, I Q Molenaar, M F J Seesing, P S N van Rossum, M A A J van den Bosch, T J M Ruers, I H M Borel Rinkes, R van Hillegersberg, M G E H Lam, H M Verkooijen
PURPOSE: Uncertainty exists regarding the optimal imaging modality for timely detection of disease progression (DP) after ablation therapy for colorectal liver metastases. We evaluated the diagnostic accuracy of (18)F-FDG PET(/CT), CT and MRI for detection of DP following ablation therapy. METHODS: A systematic search was performed on May 18, 2016. The analysis included studies that reported on the diagnostic accuracy of (18)F-FDG PET(/CT), CT and/or MRI for post-ablative evaluation of patients with liver metastases...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28302001/liver-transplantation-for-hepatocellular-carcinoma-beyond-the-milan-criteria
#8
Fulya Gunsar
Hepatocellular carcinoma is the most common primary liver malignancy. Liver transplantation has been a successful therapy for selected patients with hepatocellular carcinoma. Since 1996, Milan criteria have been universally recognized as the guidelines for selecting patients with hepatocellular carcinoma for orthotopic liver transplantation. However, the simple use of tumor size and number has been insufficient to indicate the biologic features of hepatocellular carcinoma and to predict the risk of tumor recurrence...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28266145/safety-and-efficacy-of-microwave-ablation-for-medically-inoperable-colorectal-pulmonary-metastases-single-centre-experience
#9
Craig D Ferguson, Chris R Luis, Karin Steinke
INTRODUCTION: To evaluate the safety and therapeutic efficacy of percutaneous microwave ablation (MWA) for colorectal pulmonary metastases. METHODS: Retrospective review of CT-guided lung MWA at a single tertiary institution. Adverse events within 30 days of MWA were considered procedure-related complications. Imaging follow-up was with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and contrast-enhanced CT. Response of index tumours was assessed using modified response evaluation criteria in solid tumours (mRECIST)...
March 7, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28259750/long-term-outcomes-of-salvage-stereotactic-ablative%C3%A2-radiotherapy-for-isolated-lung-recurrence-of-non-small-cell-lung-cancer-a-phase-ii-clinical-trial
#10
Bing Sun, Eric D Brooks, Ritsuko Komaki, Zhongxing Liao, Melenda Jeter, Mary McAleer, Peter A Balter, James D Welsh, Michael O'Reilly, Daniel Gomez, Stephen M Hahn, Boris Sepesi, David C Rice, John V Heymach, Joe Y Chang
OBJECTIVES: Our goal was to evaluate stereotactic ablative radiotherapy (SABR) as a salvage option for isolated recurrence of NSCLC in the lung parenchyma after definitive treatment of stage I to III disease. METHODS: Patients who had histologically confirmed, positron emission tomography-staged, isolated NSCLC recurring locally or metastasis in the lung parenchyma (≤3 cm, suitable for SABR) after previous definitive treatment were prospectively enrolled in this trial and treated with volumetric, image-guided SABR to 50 Gy in four fractions...
March 1, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28256158/treatment-outcomes-and-patterns-of-radiologic-appearance-after-hypofractionated-image-guided-radiotherapy-delivered-with-helical-tomotherapy-hht-for-lung-tumours
#11
Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
OBJECTIVE: To evaluate treatment outcomes and patterns of CT lung injury after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) in a series of inoperable lung lesions. METHODS: 68 patients who were medically inoperable (69 lesions) without evidence of viable extrathoracic disease were included. Dose prescription was driven by tumour location (hilar/pericentral vs peripheral) and/or target volume. 52% of the lesions received a biological equivalent dose (BED10) ≥100 Gy...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28218731/a-single-use-in-vitro-biosensor-for-the-detection-of-t-tau-protein-a-biomarker-of-neuro-degenerative-disorders-in-pbs-and-human-serum-using-differential-pulse-voltammetry-dpv
#12
Yifan Dai, Alireza Molazemhosseini, Chung Chiun Liu
A single-use, in vitro biosensor for the detection of T-Tau protein in phosphate-buffer saline (PBS) and undiluted human serum was designed, manufactured, and tested. Differential pulse voltammetry (DPV) served as the transduction mechanism. This biosensor consisted of three electrodes: working, counter, and reference electrodes fabricated on a PET sheet. Both working and counter electrodes were thin gold film, 10 nm in thickness. Laser ablation technique was used to define the size and structure of the biosensor...
February 19, 2017: Biosensors
https://www.readbyqxmd.com/read/28184942/radiological-biomarkers-for-assessing-response-to-locoregional-therapies-in-hepatocellular-carcinoma-from-morphological-to-functional-imaging-review
#13
REVIEW
Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28181822/oncogenic-osteomalacia-role-of-ga-68-dotanoc-pet-ct-scan-in-identifying-the-culprit-lesion-and-its-management
#14
Deepa Singh, Aditi Chopra, Mudalsha Ravina, Srikant Kongara, Eesh Bhatia, Narvesh Kumar, Sushil Gupta, Subhash Yadav, Preeti Dabadghao, Rajnikant Yadav, Veeresh Dube, Utham Kumar, Manish Dixit, Sanjay Gambhir
OBJECTIVE: The aim of this study was to evaluate the role of (68)Ga-DOTANOC positron emission tomography (PET)/CT scan in localization of culprit lesion for biopsy and required intervention [surgical excision/radiofrequency ablation (RFA)] in patients with long-standing oncogenic osteomalacia (OOM)/tumour-induced osteomalacia. METHODS: 17 patients (8 males and 9 females) underwent (68)Ga-DOTANOC PET/CT scan. The patients referred with clinical and biochemical evidence of hypophosphatemia and raised fibroblast growth factor-23...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28180965/-18-f-fdg-pet-as-novel-imaging-biomarker-for-disease-progression-after-ablation-therapy-in-colorectal-liver-metastases
#15
M Samim, W Prevoo, B J de Wit-van der Veen, K F Kuhlmann, T Ruers, R van Hillegersberg, M A A J van den Bosch, H M Verkooijen, M G E H Lam, M P M Stokkel
PURPOSE: Recurrent disease following thermal ablation therapy is a frequently reported problem. Preoperative identification of patients with high risk of recurrent disease might enable individualized treatment based on patients' risk profile. The aim of the present work was to investigate the role of metabolic parameters derived from the pre-ablation (18)F-FDG PET/CT as imaging biomarkers for recurrent disease in patients with colorectal liver metastases (CLM). METHODS: Included in this retrospective study were all consecutive patients with CLM treated with percutaneous or open thermal ablation therapy who had a pre-treatment baseline (18)F-FDG PET/CT available...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28134698/68ga-exendin-4-pet-ct-in-evaluation-of-endoscopic-ultrasound-guided-ethanol-ablation-of-an-insulinoma
#16
Yaping Luo, Ji Li, Aiming Yang, Hongbo Yang, Fang Li
A 32-year-old man with endogenous hyperinsulinemic hypoglycemia was clinically diagnosed with an insulinoma. Conventional imaging result was negative, and a previous exploratory laparotomy with distal pancreatectomy failed to detect the tumor. Ga-exendin-4 PET/CT showed a lesion with intense radioactivity in the head of the pancreas suggestive of an insulinoma, and endoscopic ultrasound-guided ethanol ablation was performed. Postablation evaluation with Ga-exendin-4 PET/CT showed markedly decreased radioactivity of the tumor...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28129789/short-report-interim-safety-results-for-a-phase-ii-trial-measuring-the-integration-of-stereotactic-ablative-radiotherapy-sabr-plus-surgery-for-early-stage-non-small-cell-lung-cancer-missile-nsclc
#17
David A Palma, Timothy K Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V Louie, Eric Frechette, George B Rodrigues, Brian Yaremko, Edward Yu, A Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner, Aaron Ward, Richard Inculet
A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We report a mandated interim safety analysis for the first 10 patients who completed protocol treatment. Operable patients with biopsy-proven T1-2 N0 NSCLC were eligible. SABR was delivered using a risk-adapted fractionation (54Gy/3 fractions, 55/5 or 60/8). Surgical resection was planned 10 weeks later at a high-volume center (>200 lung cancer resections annually)...
January 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28126325/stereotactic-ablative-radiation-therapy-for-lung-oligometastases-predictive-parameters-of-early-response-by-18-fdg-pet-ct
#18
Rosario Mazzola, Alba Fiorentino, Gioacchino Di Paola, Niccolò Giaj Levra, Francesco Ricchetti, Sergio Fersino, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVES: The objective of this study was to investigate fludeoxyglucose F 18 positron emission tomography/computed tomography ((18)FDG-PET/CT) parameters as predictive of response after stereotactic ablative radiotherapy (SABR) for lung oligometastases. METHODS: The inclusion criteria of the current retrospective study were as follows: (1) lung oligometastases treated by SABR, (2) presence of (18)FDG-PET/CT before and after SABR for at least two subsequent evaluations, (3) Karnofsky performance status higher than 80, and (4) life expectancy longer than 6 months...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28116853/utility-of-68-ga-prostate-specific-membrane-antigen-positron-emission-tomography-in-diagnosis-and-response-assessment-of-recurrent-renal-cell-carcinoma
#19
Shankar Siva, Jason Callahan, David Pryor, Jarad Martin, Nathan Lawrentschuk, Michael S Hofman
INTRODUCTION: Prostate specific membrane antigen (PSMA) positron emission tomography (PET) is an emerging imaging modality in prostate cancer. However, (68) Ga-PSMA-PET may also have diagnostic utility in the setting of renal cell carcinoma (RCC). We investigate the differential role of (18) F-fluorodeoxyglucose (FDG) and PSMA-PET/CT scanning in patients with oligometastatic RCC. In particular, we focus on the utility of PSMA-PET for diagnostic evaluation of isolated or limited metastases planned for local surgery or radiation, as well as the potential utility of PSMA-PET for therapeutic response assessment in patients receiving stereotactic ablative body radiotherapy (SABR)...
January 24, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28092172/analysis-of-indium-tin-oxide-film-using-argon-fluroide-arf-laser-excited-atomic-fluorescence-of-ablated-plumes
#20
Sut Kam Ho, Dario Machado Garcia
A two-pulse laser-excited atomic fluorescence (LEAF) technique at 193 nm wavelength was applied to the analysis of indium tin oxide (ITO) layer on polyethylene terephthalate (PET) film. Fluorescence emissions from analytes were induced from plumes generated by first laser pulse. Using this approach, non-selective LEAF can be accomplished for simultaneous multi-element analysis and it overcomes the handicap of strict requirement for laser excitation wavelength. In this study, experimental conditions including laser fluences, times for gating and time delay between pulses were optimized to reveal high sensitivity with minimal sample destruction and penetration...
January 1, 2017: Applied Spectroscopy
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