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pet ablation

Hyeonseok S Jeong, Eun Kyoung Choi, In-Uk Song, Yong-An Chung, Jong-Sik Park, Jin Kyoung Oh
BACKGROUND: In preparation for I-131 ablation, temporary withdrawal of thyroid hormone is commonly used in patients with thyroid cancer after total thyroidectomy. The current study aimed to investigate brain glucose metabolism and its relationships with mood or cognitive function in these patients using 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG-PET). METHOD: A total of 40 consecutive adult patients with thyroid carcinoma who had undergone total thyroidectomy were recruited for this cross-sectional study...
October 22, 2016: Thyroid: Official Journal of the American Thyroid Association
Saima Riaz, Humayun Bashir, Aamna Hassan, Sajid Mushtaq, Arif Jamshed, Ahmad Murtaza
We report an aggressive papillary thyroid carcinoma (PTC) with focal undifferentiated component in a 32-year-old female. She had limited disease confined within the thyroid gland at diagnosis. Within 12 months of thyroidectomy and radioiodine ablation, thyroglobulin (Tg) levels were elevated. Second radioiodine ablative dose was given, however, stimulated Tg levels showed an upward trend with negative iodine scan within 12 months. An 18F fludeoxyglucose-avid solitary pulmonary nodule that was detected on positron emission tomography/computed tomography scan was resected followed by empiric radioiodine therapy...
October 5, 2016: Molecular Imaging and Radionuclide Therapy
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
N D Prionas, S Aggarwal, J Shaffer, R von Eyben, E E Graves, P G Maxim, A Quon, M F Gensheimer, M Diehn, B W Loo
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
David Jonathan Heineman, Martijn Geert Ten Berge, Johannes Marlene Daniels, Michaël Ignatius Versteegh, Perla Jacqueline Marang-van de Mheen, Michael Wilhelmus Wouters, Wilhelmina Hendrika Schreurs
BACKGROUND: The clinical stage of non-small cell lung cancer (NSCLC) determines the initial treatment, whereas the pathologic stage best determines prognosis and the need for adjuvant treatment. In an era in which stereotactic ablative radiotherapy (SABR) has become an alternative modality to surgical intervention, clinical staging is even more important, because pathologic staging is omitted in the case of SABR. The objective of this study was to determine the concordance between clinical and pathologic stage in routine clinical practice for patients with early-stage NSCLC...
September 21, 2016: Annals of Thoracic Surgery
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND Hepatitis C virus (HCV) genotype 4 (GT-4) is widespread in the Middle East, where it is responsible for the majority of HCV infections. It shows moderate treatment response rates when compared to other genotypes in the current era of interferon-based regimens. However, in the era of direct acting antiviral (DAA) drugs, its response is at least as good as observed for HCV genotypes 1-3. CASE REPORT We present a case of a 44-year-old patient with HCV cirrhosis. Since 2007, he has been treated for HCV infection with multiple ineffective regimens of interferon (INF) and ribavirin...
September 20, 2016: American Journal of Case Reports
Mrinal Yadava, Michael D Shapiro
Imaging modalities such as computed tomography, magnetic resonance, positron emission tomography, and single-photon emission computed tomography are an indispensable component of cardiac arrhythmia management. Over the last two decades, developments in imaging techniques have facilitated safer and more effective cardiac ablation and device implantation procedures. Pre-procedural assessment of arrhythmogenic substrate and integration with electroanatomic data has significantly impacted the management of atrial fibrillation and ventricular tachycardia...
November 2016: Current Treatment Options in Cardiovascular Medicine
Philip Cornford, Joaquim Bellmunt, Michel Bolla, Erik Briers, Maria De Santis, Tobias Gross, Ann M Henry, Steven Joniau, Thomas B Lam, Malcolm D Mason, Henk G van der Poel, Theo H van der Kwast, Olivier Rouvière, Thomas Wiegel, Nicolas Mottet
OBJECTIVE: To present a summary of the 2016 version of the European Association of Urology (EAU) - European Society for Radiotherapy & Oncology (ESTRO) - International Society of Geriatric Oncology (SIOG) Guidelines on the treatment of relapsing, metastatic, and castration-resistant prostate cancer (CRPC). EVIDENCE ACQUISITION: The working panel performed a literature review of the new data (2013-2015). The guidelines were updated, and the levels of evidence and/or grades of recommendation were added based on a systematic review of the literature...
August 31, 2016: European Urology
Tzu-Yuan Chou, Yung-Shin Sun, Hsien-San Hou, Shang-Ying Wu, Yun Zhu, Ji-Yen Cheng, Kai-Yin Lo
Microfluidic devices are capable of creating a precise and controllable cellular micro-environment of pH, temperature, salt concentration, and other physical or chemical stimuli. They have been commonly used for in vitro cell studies by providing in vivo like surroundings. Especially, how cells response to chemical gradients, electrical fields, and shear stresses has drawn many interests since these phenomena are important in understanding cellular properties and functions. These microfluidic chips can be made of glass substrates, silicon wafers, polydimethylsiloxane (PDMS) polymers, polymethylmethacrylate (PMMA) substrates, or polyethyleneterephthalate (PET) substrates...
2016: Journal of Visualized Experiments: JoVE
B Ghaye, M Wanet, M El Hajjam
Radiation-induced lung disease (RILD) is frequent after therapeutic irradiation of thoracic malignancies. Many technique-, treatment-, tumor- and patient-related factors influence the degree of injury sustained by the lung after irradiation. Based on the time interval after the completion of the treatment RILD presents as early and late features characterized by inflammatory and fibrotic changes, respectively. They are usually confined to the radiation port. Though the typical pattern of RILD is easily recognized after conventional two-dimensional radiation therapy (RT), RILD may present with atypical patterns after more recent types of three- or four-dimensional RT treatment...
October 2016: Diagnostic and Interventional Imaging
Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W Meyer, Paul T Pfluger, Ana M Fernandez, Serge Luquet, Stephen C Woods, Ignacio Torres-Alemán, C Ronald Kahn, Magdalena Götz, Tamas L Horvath, Matthias H Tschöp
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal ablation of insulin receptors (IRs) in glial fibrillary acidic protein (GFAP)-expressing cells affects hypothalamic astrocyte morphology, mitochondrial function, and circuit connectivity. Accordingly, astrocytic IR ablation reduces glucose-induced activation of hypothalamic pro-opio-melanocortin (POMC) neurons and impairs physiological responses to changes in glucose availability...
August 11, 2016: Cell
Daniele Muser, Pasquale Santangeli, Rajeev K Pathak, Simon A Castro, Jackson J Liang, Silvia Magnani, Tatsuya Hayashi, Fermin C Garcia, Mathew D Hutchinson, Gregory E Supple, David S Frankel, Michael P Riley, David Lin, Robert D Schaller, Benoit Desjardins, Sanjay Dixit, David J Callans, Erica S Zado, Francis E Marchlinski
BACKGROUND: Catheter ablation (CA) of ventricular tachycardia (VT) in patients with cardiac sarcoidosis can be challenging because of the complex underlying substrate. We sought to determine the long-term outcome of CA of VT in patients with cardiac sarcoidosis. METHODS AND RESULTS: We enrolled 31 patients (age, 55±10 years) with diagnosis of cardiac sarcoidosis based on Heart Rhythm Society criteria and VT who underwent CA. In 23 (74%) patients, preprocedure cardiac magnetic resonance imaging and positron emission tomographic (PET) evaluation were performed...
August 2016: Circulation. Arrhythmia and Electrophysiology
Amandine Crombé, Xavier Buy, Yann Godbert, Nicolas Alberti, Michèle Kind, Françoise Bonichon, Jean Palussière
An 82-year-old man, who was diagnosed in 2002 with an oncocytic (Hürthle cell) thyroid carcinoma, was initially treated by local surgery and was refractory to radioiodine treatment. The patient had successive secondary recurrences from 2006 onwards. Metastases were suspected due to an elevation of thyroglobulin in serum. Hypermetabolic nodules were targeted using FDG PET as well as CT-guided radiofrequency ablations. Thyroglobulin levels decreased following each procedure. 10 years later, tolerance and efficacy are excellent; 23 lung metastases have been treated during 11 sessions without current relapse...
August 8, 2016: Cardiovascular and Interventional Radiology
Sleiman Y Naddaf, Ghulam Mustafa Shah Syed, Abdulrahman Hadb, Saif Al-Thaqfi
We report a case of a 60-year-old man diagnosed with papillary thyroid cancer who had a relapse seen only in the brain at FDG PET on standard images. Total thyroidectomy was performed in July 2013 after initial diagnosis. Patient received I ablation in December 2013, followed by external beam radiotherapy to the neck. In September 2015, the patient presented with neurological symptoms. Brain MRI showed multiple brain metastases later confirmed on histopathology. An FDG PET/CT scan was performed to evaluate the whole body in November 2015...
September 2016: Clinical Nuclear Medicine
Aukje A J M van Tilborg, Hester J Scheffer, Marcus C de Jong, Laurien G P H Vroomen, Karin Nielsen, Cornelis van Kuijk, Petrousjka M P van den Tol, Martijn R Meijerink
PURPOSE: To retrospectively analyse the safety and efficacy of radiofrequency ablation (RFA) versus microwave ablation (MWA) in the treatment of unresectable colorectal liver metastases (CRLM) in proximity to large vessels and/or major bile ducts. METHOD AND MATERIALS: A database search was performed to include patients with unresectable histologically proven and/or (18)F-FDG-PET avid CRLM who were treated with RFA or MWA between January 2001 and September 2014 in a single centre...
October 2016: Cardiovascular and Interventional Radiology
Bettina Hjelm Clausen, Matilda Degn, Mithula Sivasaravanaparan, Torben Fogtmann, Maria Gammelstrup Andersen, Michelle D Trojanowsky, Han Gao, Svend Hvidsten, Christina Baun, Tomas Deierborg, Bente Finsen, Bjarne Winther Kristensen, Sara Thornby Bak, Morten Meyer, Jae Lee, Sergei A Nedospasov, Roberta Brambilla, Kate Lykke Lambertsen
Microglia are activated following cerebral ischemia and increase their production of the neuro- and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function of TNF from this cellular source in focal cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in which the TNF gene was deleted in cells of the myeloid lineage, including microglia. The deletion reduced secreted TNF levels in lipopolysaccharide-stimulated cultured primary microglia by ~93%. Furthermore, phosphorylated-ERK/ERK ratios were significantly decreased in naïve LysMcreTNF(fl/fl) mice demonstrating altered ERK signal transduction...
2016: Scientific Reports
Caroline Toelen, Marc De Maeyer, Paul Van Schil
A patient with a history of colon adenocarcinoma was referred for resection of two lung lesions suspect for metastases. Three additional nodular areas were removed by wedge excision. Pathologic examination revealed four different diagnoses. This particular case demonstrates that the number of lesions may be underestimated on preoperative imaging, even on high-resolution computed tomography and positron emission tomography. Equally, pathologic examination of all detected lesions is vitally important to decide optimal treatment and to determine prognosis...
July 4, 2016: Acta Chirurgica Belgica
Junjie Li, Min Zhou, Fengyong Liu, Chiyi Xiong, Wanqin Wang, Qizhen Cao, Xiaoxia Wen, J David Robertson, Xin Ji, Y Andrew Wang, Sanjay Gupta, Chun Li
Purpose To determine if combretastatin A-4 phosphate disodium (CA4P) can enhance the tumor uptake of doxorubicin (Dox)-loaded, polyethylene glycol (PEG)-coated hollow gold nanospheres (HAuNS) mixed with ethiodized oil for improved photothermal ablation (PTA)-chemoembolization therapy (CET) of hepatocellular carcinoma (HCC) in rats. Materials and Methods Animal experiments were approved by the institutional animal care and use committee and performed from February 2014 to April 2015. Male Sprague-Dawley rats (n = 45; age, 12 weeks) were inoculated with N1S1 HCC cells in the liver, and 8 days later, were randomly divided into two groups of 10 rats...
June 27, 2016: Radiology
Alda L Tam, Marites P Melancon, Mohamed Abdelsalam, Tomas Appleton Figueira, Katherine Dixon, Amanda McWatters, Min Zhou, Qian Huang, Osama Mawlawi, Kenneth Dunner, Chun Li, Sanjay Gupta
Combining image-guided therapy techniques for the treatment of liver cancers is a strategy that is being used to improve local tumor control rates. Here, we evaluate the intratumoral uptake of nanoparticles used in combination with radiofrequency ablation (RFA), irreversible electroporation (IRE), or laser induced thermal therapy (LITT). Eight rabbits with VX2 tumor in the liver underwent one of four treatments: (i) nanoembolization (NE) with radiolabeled, hollow gold nanoparticles loaded with doxorubicin (⁶⁴Cu-PEG-HAuNS-DOX); (ii) NE + RFA; (iii) NE + IRE; (iv) NE +LITT...
February 2016: Journal of Biomedical Nanotechnology
Min Zhou, Marites Melancon, R Jason Stafford, Junjie Li, Alpa M Nick, Mei Tian, Anil K Sood, Chun Li
Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment. Here, we investigated the feasibility of PTT for ovarian cancer (OvC) under the guidance of positron emission tomography (PET) and magnetic resonance temperature imaging (MRTI) using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed by using highly sensitive, quantifiable PET imaging...
June 9, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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