keyword
MENU ▼
Read by QxMD icon Read
search

phenylethylamine

keyword
https://www.readbyqxmd.com/read/29234054/antagonistic-effect-of-dopamine-structural-analogues-on-human-gaba%C3%AF-1-receptor
#1
Alfredo Alaniz-Palacios, Ataulfo Martínez-Torres
GABAergic and dopaminergic pathways are co-localized in several areas of the central nervous system and recently several reports have shown co-release of both neurotransmitters. The GABA-A receptor (β and ρ1 subunits) is modulated by dopamine (DA) and, interestingly, GABAρ1 can be modulated by several biogenic amines. Here we explored the effects of the metabolites of the dopaminergic pathway and other structural analogues of DA on GABAρ1 and the DA gated ion channel (LGC-53) from Caenorhabditis elegans expressed in Xenopus laevis oocytes...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228118/where-is-the-tmt-gc-ms-analyses-of-fox-feces-and-behavioral-responses-of-rats-to-fear-inducing-odors
#2
Olivier Rampin, Nathalie Jerôme, Audrey Saint-Albin, Christian Ouali, Frank Boué, Nicolas Meunier, Birte L Nielsen
TMT (2,5-dihydro-2,4,5-trimethylthiazoline) is known as a component of fox feces inducing fear in rodents. However, no recent chemical analyses of fox feces are available, and few studies make direct comparisons between TMT and fox feces. Fox feces from 3 individuals were used to prepare 24 samples to be analyzed for the presence of TMT using gas chromatography-mass spectrometry (GC-MS). When TMT was added in low amounts (50-2000 nmol/g), TMT was detected in 10 out of 11 samples. When no TMT was added, TMT was detected in only 1 out of 13 samples...
December 8, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29202379/platelet-monoamine-oxidase-activity-and-interpersonal-violence-in-male-suicide-attempters
#3
Jussi Jokinen, Johan Königsson, Tomas Moberg, Erik G Jönsson, Jari Tiihonen, Peter Nordström, Lars Oreland, Marie Åsberg
Low platelet monoamine oxidase B (MAO-B) activity, proxy of low central serotonergic functions, has been shown to correlate with criminal behavior in adolescents that come from an unfavorable psychosocial environment but not in adolescents from good conditions, indicating a link between environment, MAO-B activity and aggressive behavior. The purpose of this study was to examine the association between MAO-B activity and lifetime interpersonal violence in suicide attempters. The study included a total of 28 suicide attempters (18 men and 10 women)...
November 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29116873/the-effect-of-experimental-supplementation-with-the-klamath-algae-extract-klamin-on-attention-deficit-hyperactivity-disorder
#4
Maurizio Cremonte, Davide Sisti, Ilaria Maraucci, Simona Giribone, Evelin Colombo, Marco Bruno Luigi Rocchi, Stefano Scoglio
Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological condition with onset in childhood. The disorder is characterized by inattention, impulsivity, and/or motor hyperactivity, which often affect the development and social integration of affected subjects. Phenylethylamine (PEA), naturally contained in the Klamath Lake microalgae and concentrated in the Klamin(®) extract, is an endogenous molecule with a general neuromodulatory activity. It functions as an activator for the neurotransmission of dopamine and other catecholamines, and very low concentrations of PEA may be associated with specific psychological disorders such as ADHD...
November 8, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29074414/non-adrenergic-vasoconstriction-and-vasodilatation-of-guinea-pig-aorta-by-%C3%AE-phenylethylamine-and-amphetamine-role-of-nitric-oxide-determined-with-l-name-and-no-scavengers
#5
Kenneth J Broadley, Harrison D Broadley
Sympathomimetic and trace amines, including β-phenylethylamine (PEA) and amphetamine, increase blood pressure and constrict isolated blood vessels. By convention this is regarded as a sympathomimetic response, however, recent studies suggest trace amine-associated receptor (TAAR) involvement. There is also uncertainty whether these amines also release nitric oxide (NO) causing opposing vasodilatation. These questions were addressed in guinea-pig isolated aorta, a species not previously examined. Guinea-pig aortic rings were set up to measure contractile tension...
October 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28967251/total-synthesis-of-dendrochrysanene-through-a-frame-rearrangement
#6
Naoki Katsuki, Shumpei Isshiki, Daisuke Fukatsu, Juan Okamura, Kouji Kuramochi, Takeo Kawabata, Kazunori Tsubaki
The first total synthesis of dendrochrysanene (1) was achieved. The key reaction for the construction of dendrochrysanene was an oxidative frame rearrangement reaction from a phenanthrene dimer to a spiro-lactone skeleton, which we serendipitously identified. Owing to the steric hindrance of the substituent on the peri position of the phenanthrene dimer, high-temperature conditions were required for the rearrangement reaction; however, at such temperatures, the substrate decomposed. To address this issue, we added phenylethylamine or benzylamine to the reaction system...
October 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28873563/application-of-3-5-bis-trifluoromethyl-phenyl-isothiocyanate-for-the-determination-of-selected-biogenic-amines-by-lc-tandem-mass-spectrometry-and-19-f-nmr
#7
Aneta Jastrzębska, Anna Piasta, Marek Krzemiński, Edward Szłyk
3,5-Bis-(trifluoromethyl)phenyl isothiocyanate, was used as a convenient reagent for the derivatization of histamine, tyramine, tryptamine and 2-phenylethylamine, which eliminates the purification step. The obtained derivatives were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Additionally, the total amount of these amines was determined by (19)F nuclear magnetic resonance analysis. The procedures were optimized and validated for linearity, limit of detection and quantification, intra- and inter-day precision and recovery resulting in good reproducibility and accuracy...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28873546/reduction-of-biogenic-amines-in-sufu-by-ethanol-addition-during-ripening-stage
#8
Shuang Qiu, Ying Wang, Yongqiang Cheng, Yan Liu, Madhav P Yadav, Lijun Yin
The aim of this study was to investigate the content of biogenic amines (BAs) in different types of sufu samples obtained from different producers, and the effect of ethanol in reducing BA levels during sufu ripening. The results showed that different manufacturing processes altered the distribution of BAs in commercial sufu. Putrescine, cadaverine, histamine, and tryptamine were the main and common BAs in red, white and grey sufu. The contents of putrescine, cadaverine, tryptamine, β-phenylethylamine and tyramine in the grey sufu of all producer brands were significantly (p<0...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28841190/alkaloids-from-oxytropis-myriophylla-pall-dc
#9
Keisuke Kojima, Purevsuren S, Narantuya S, Tsetsegmaa S, Jamyansan Ya, Kimio Lsaka, Yukio Ogihara
Five alkaloids were isolated from the epigeal part of Oxytropis myriophylla. Three alkaloids were identified as N-benzoyl-β-phenylethylamine, N-trans-cinnamoyl-β-phenylethylamine, N-cis-cinnamoyl-β-phenylethylamine and the structures of two new alkaloids were elucidated to be N-benzoyl-β-hydroxyphenylethylarnine(2), N-trans-cinnamoyl-β-hydroxy-phenylethylamine(5). The absolu.te structures were established by modified Mosher method.
August 25, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28738644/biosensor-for-the-characterisation-of-hmao-b-inhibitors-and-the-quantification-of-selegiline
#10
Maximilian Aigner, Patricia Preissegger, Kurt Kalcher, Eda Mehmeti, Peter Macheroux, Dale Edmondson, Astrid Ortner
A novel human monoamine oxidase B (hMAO B) based biosensor for inhibitory measurements was developed. It allows both the characterisation of the type of enzyme inhibition and the sensitive and simple determination of inhibitors like selegiline hydrochloride. The sensor consists of a screen printed carbon working electrode modified with 20% manganese dioxide (MnO2) and the enzyme hMAO B, which was immobilised on the electrode via a dialysis membrane (regenerated cellulose, molecular weight cut-off 14000). Inhibition of hMAO B is evaluated by adding different concentrations of the inhibitor selegiline hydrochloride to the enzyme and applying a defined amount of the hMAO B substrate phenylethylamine (PEA)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28706468/retinal-metabolic-events-in-preconditioning-light-stress-as-revealed-by-wide-spectrum-targeted-metabolomics
#11
Juan Manuel Chao de la Barca, Nuan-Ting Huang, Haihan Jiao, Lydie Tessier, Cédric Gadras, Gilles Simard, Riccardo Natoli, Guillaume Tcherkez, Pascal Reynier, Krisztina Valter
INTRODUCTION: Light is the primary stimulus for vision, but may also cause damage to the retina. Pre-exposing the retina to sub-lethal amount of light (or preconditioning) improves chances for retinal cells to survive acute damaging light stress. OBJECTIVES: This study aims at exploring the changes in retinal metabolome after mild light stress and identifying mechanisms that may be involved in preconditioning. METHODS: Retinas from 12 rats exposed to mild light stress (1000 lux × for 12 h) and 12 controls were collected one and seven days after light stress (LS)...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28675687/disruptive-physiology-olfaction-and-the-microbiome-gut-brain-axis
#12
John Bienenstock, Wolfgang A Kunze, Paul Forsythe
This review covers the field of olfaction and chemosensation of odorants and puts this information into the context of interactions between microbes and behaviour; the microbiome-gut-brain axis (MGBA). Recent emphasis has also been placed on the concept of the holobiome which states that no single aspect of an organism should be viewed separately and thus must include examination of their associated microbial populations and their influence. While it is known that the microbiome may be involved in the modulation of animal behaviour, there has been little systematized effort to incorporate into such studies the rapidly developing knowledge of the wide range of olfactory systems...
July 4, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28655495/tranylcypromine-in-mind-part-i-review-of-pharmacology
#13
REVIEW
Sven Ulrich, Roland Ricken, Mazda Adli
It has been over 50 years since a review has focused exclusively on the monoamine oxidase (MAO) inhibitor tranylcypromine (TCP). A new review has therefore been conducted for TCP in two parts which are written to be read preferably in close conjunction: Part I - pharmacodynamics, pharmacokinetics, drug interactions, toxicology; and Part II - clinical studies with meta-analysis of controlled studies in depression, practice of TCP treatment, place in therapy. Pharmacological data of this review part I characterize TCP as an irreversible and nonselective MAO-A/B inhibitor at low therapeutic doses of 20mg/day with supplementary norepinephrine reuptake inhibition at higher doses of 40-60mg/day...
June 24, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28650006/positional-immobilization-of-pd-nanoparticles-and-enzymes-in-hierarchical-yolk-shell-shell-nanoreactors-for-tandem-catalysis
#14
Xiaoming Zhang, Lingyan Jing, Fangfang Chang, Shuai Chen, Hengquan Yang, Qihua Yang
A hierarchical yolk-shell@shell nanoreactor that spatially positioned Pd nanoparticles and the CALB enzyme in separated domains is constructed, and served as an efficient bifunctional catalyst for the one-pot dynamic kinetic resolution (DKR) reaction of 1-phenylethylamine with excellent activity and selectivity.
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28623006/a-longevity-study-with-enhancer-substances-selegiline-bpap-detected-an-unknown-tumor-manifestation-suppressing-regulation-in-rat-brain
#15
J Knoll, K Baghy, S Eckhardt, P Ferdinandy, M Garami, L G Harsing, P Hauser, Z Mervai, T Pocza, Z Schaff, D Schuler, I Miklya
AIMS: First proof to show that (-)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP), the tryptamine-derived presently known most potent, selective, synthetic enhancer substance, are specific markers of unknown enhancer-sensitive brain regulations. MAIN METHODS: Longevity study disclosing the operation of tumor-manifestation-suppressing (TMS) regulation in rat brain...
August 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28583428/multiscale-simulation-of-monoamine-oxidase-catalyzed-decomposition-of-phenylethylamine-analogs
#16
Gabriel Oanca, Jernej Stare, Robert Vianello, Janez Mavri
Phenylethylamine (PEA) is an endogenous amphetamine and its levels are increased by physical activity. As other biogenic monoamines, it is decomposed by monoamine oxidase (MAO) enzymes. The chemical mechanism of MAO, and flavoenzymes in general, is a subject of heated debate. We have previously shown that the rate-limiting step of MAO catalysis involves a hydride transfer from the substrate methylene group vicinal to the amino group to the N5 atom of the lumiflavin co-factor moiety. By using multiscale simulation on the Empirical Valence Bond (EVB) level, we studied the chemical reactivity of the monoamine oxidase B catalyzed decomposition of PEA and its two derivatives: p-chloro-β-methylphenylamine (p-CMP) and p-methoxy-β-methylphenethylamine (p-MMP)...
June 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28429993/interactive-effects-of-protein-and-carbohydrates-on-production-of-microbial-metabolites-in-the-large-intestine-of-growing-pigs
#17
Marcin Taciak, Marcin Barszcz, Ewa Święch, Anna Tuśnio, Ilona Bachanek
The study aimed at determining the effect of protein type and indigestible carbohydrates on the concentration of microbial metabolites in the large intestine of pigs. The experiment involved 36 pigs (15 kg initial body weight) divided into six groups, fed cereal-based diets with highly digestible casein (CAS) or potato protein concentrate (PPC) of lower ileal digestibility. Each diet was supplemented with cellulose, raw potato starch or pectin. After 2 weeks of feeding, pigs were sacrificed and samples of caecal and ascending, transverse and descending colon digesta were collected for analyses of microbial metabolites...
June 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28342109/sensitivity-to-enterocins-of-biogenic-amine-producing-faecal-enterococci-from-ostriches-and-pheasants
#18
Andrea Lauková, Anna Kandričáková, Leona Buňková, Pavel Pleva, Jana Ščerbová
Enterococci are widespread bacteria forming the third largest genus among lactic acid bacteria. Some possess probiotic properties or they can produce beneficial proteinaceous antimicrobial substances called enterocins. On the other hand, some enterococci produce biogenic amines (BAs), so this study is focused on the sensitivity to enterocins of biogenic amine-producing faecal enterococci from ostriches and pheasants. Altogether, 60 enterococci isolated from faeces of ostriches and pheasants were tested for production of BAs...
March 24, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28315773/the-time-enzyme-in-melatonin-biosynthesis-in-fish-day-night-expressions-of-three-aralkylamine-n-acetyltransferase-genes-in-three-spined-stickleback
#19
REVIEW
Ewa Kulczykowska, Agnieszka Kleszczyńska, Magdalena Gozdowska, Ewa Sokołowska
In vertebrates, aralkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) is a time-keeping enzyme in melatonin (Mel) biosynthesis. Uniquely in fish, there are several AANAT isozymes belonging to two AANAT subfamilies, AANAT1 and AANAT2, which are encoded by distinct genes. The different substrate preferences, kinetics and spatial expression patterns of isozymes indicate that they may have different functions. In the three-spined stickleback (Gasterosteus aculeatus), there are three genes encoding three AANAT isozymes...
June 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28271887/total-synthesis-and-stereochemical-assignment-of-delavatine-a-rh-catalyzed-asymmetric-hydrogenation-of-indene-type-tetrasubstituted-olefins-and-kinetic-resolution-through-pd-catalyzed-triflamide-directed-c-h-olefination
#20
Zhongyin Zhang, Jinxin Wang, Jian Li, Fan Yang, Guodu Liu, Wenjun Tang, Weiwei He, Jian-Jun Fu, Yun-Heng Shen, Ang Li, Wei-Dong Zhang
Delavatine A (1) is a structurally unusual isoquinoline alkaloid isolated from Incarvillea delavayi. The first and gram-scale total synthesis of 1 was accomplished in 13 steps (the longest linear sequence) from commercially available starting materials. We exploited an isoquinoline construction strategy and developed two reactions, namely Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution of β-alkyl phenylethylamine derivatives through Pd-catalyzed triflamide-directed C-H olefination...
April 5, 2017: Journal of the American Chemical Society
keyword
keyword
31200
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"