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phenylethylamine

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https://www.readbyqxmd.com/read/28429993/interactive-effects-of-protein-and-carbohydrates-on-production-of-microbial-metabolites-in-the-large-intestine-of-growing-pigs
#1
Marcin Taciak, Marcin Barszcz, Ewa Święch, Anna Tuśnio, Ilona Bachanek
The study aimed at determining the effect of protein type and indigestible carbohydrates on the concentration of microbial metabolites in the large intestine of pigs. The experiment involved 36 pigs (15 kg initial body weight) divided into six groups, fed cereal-based diets with highly digestible casein (CAS) or potato protein concentrate (PPC) of lower ileal digestibility. Each diet was supplemented with cellulose, raw potato starch or pectin. After 2 weeks of feeding, pigs were sacrificed and samples of caecal and ascending, transverse and descending colon digesta were collected for analyses of microbial metabolites...
June 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28342109/sensitivity-to-enterocins-of-biogenic-amine-producing-faecal-enterococci-from-ostriches-and-pheasants
#2
Andrea Lauková, Anna Kandričáková, Leona Buňková, Pavel Pleva, Jana Ščerbová
Enterococci are widespread bacteria forming the third largest genus among lactic acid bacteria. Some possess probiotic properties or they can produce beneficial proteinaceous antimicrobial substances called enterocins. On the other hand, some enterococci produce biogenic amines (BAs), so this study is focused on the sensitivity to enterocins of biogenic amine-producing faecal enterococci from ostriches and pheasants. Altogether, 60 enterococci isolated from faeces of ostriches and pheasants were tested for production of BAs...
March 24, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28315773/the-time-enzyme-in-melatonin-biosynthesis-in-fish-day-night-expressions-of-three-aralkylamine-n-acetyltransferase-genes-in-three-spined-stickleback
#3
REVIEW
Ewa Kulczykowska, Agnieszka Kleszczyńska, Magdalena Gozdowska, Ewa Sokołowska
In vertebrates, aralkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) is a time-keeping enzyme in melatonin (Mel) biosynthesis. Uniquely in fish, there are several AANAT isozymes belonging to two AANAT subfamilies, AANAT1 and AANAT2, which are encoded by distinct genes. The different substrate preferences, kinetics and spatial expression patterns of isozymes indicate that they may have different functions. In the three-spined stickleback (Gasterosteus aculeatus), there are three genes encoding three AANAT isozymes...
June 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28271887/total-synthesis-and-stereochemical-assignment-of-delavatine-a-rh-catalyzed-asymmetric-hydrogenation-of-indene-type-tetrasubstituted-olefins-and-kinetic-resolution-through-pd-catalyzed-triflamide-directed-c-h-olefination
#4
Zhongyin Zhang, Jinxin Wang, Jian Li, Fan Yang, Guodu Liu, Wenjun Tang, Weiwei He, Jian-Jun Fu, Yun-Heng Shen, Ang Li, Wei-Dong Zhang
Delavatine A (1) is a structurally unusual isoquinoline alkaloid isolated from Incarvillea delavayi. The first and gram-scale total synthesis of 1 was accomplished in 13 steps (the longest linear sequence) from commercially available starting materials. We exploited an isoquinoline construction strategy and developed two reactions, namely Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution of β-alkyl phenylethylamine derivatives through Pd-catalyzed triflamide-directed C-H olefination...
April 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28244748/the-2014-philip-s-portoghese-medicinal-chemistry-lectureship-the-phenylalkylaminome-with-a-focus-on-selected-drugs-of-abuse-%C3%A2
#5
Richard A Glennon
The phenylalkylamine, particularly the phenylethylamine, moiety is a common structural feature found embedded in many clinically approved agents. Greater still is its occurrence in drugs of abuse. The simplest phenylethylamine, 2-phenylethylamine itself, is without significant central action when administered at moderate doses, but fairly simple structural modifications profoundly impact its pharmacology and result in large numbers of useful pharmacological tools, agents with therapeutic potential, and in drugs of abuse (e...
April 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28221886/technological-properties-and-biogenic-amines-production-by-bacteriocinogenic-lactococci-and-enterococci-strains-isolated-from-raw-goat-s-milk
#6
Luana Martins Perin, Simona Belviso, Barbara Dal Bello, Luís Augusto Nero, Luca Cocolin
Technological properties and biogenic amine production were analyzed in 56 bacteriocinogenic lactococci and enterococci strains isolated from raw goat's milk. Fifteen lactococci strains were able to reduce milk pH to 5.3 or lower after 6 h, while enterococci strains were initially slow in producing acids. Lactococcus lactis subsp. lactis GLc06 and three strains of Enterococcus faecalis (GEn20, GEn22, and GEn23) presented high proteolytic activity. L. lactis subsp. lactis GLc06 and E. faecalis GEn22 also showed a high percentage of autolysis after only 4 h, reaching 71...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28159615/immobilization-of-r-%C3%AF-transaminase-on-mno2-nanorods-for-catalyzing-the-conversion-of-r-1-phenylethylamine
#7
Jian Sun, Wen-Hui Cui, Kun Du, Qian Gao, Mengmeng Du, Peijun Ji, Wei Feng
R-ɷ-transaminases transfer an amino group from an amino donor (e.g. (R)-1-phenylethylamine) onto an amino acceptor (e.g. pyruvate), resulting a co-product (e.g. d-alanine). This work intends to immobilize R-ɷ-Transaminase on MnO2 nanorods to achieve multienzyme catalysis. R-ɷ-Transaminase (RTA) and d-amino acid oxidase (DAAO) have been fused to an elastin-like polypeptide (ELP) separately through genetic engineering of the enzymes. ELP-RTA and ELP-DAAO have been separately immobilized on polydopamine-coated MnO2 nanorods...
March 10, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28124803/employing-two-stage-derivatisation-and-gc-ms-to-assay-for-cathine-and-related-stimulant-alkaloids-across-the-celastraceae
#8
Luke R Tembrock, Corey D Broeckling, Adam L Heuberger, Mark P Simmons, Frank R Stermitz, Jessica M Uvarov
INTRODUCTION: Catha edulis (qat, khat, mirra) is a woody plant species that is grown and consumed in East Africa and Yemen for its stimulant alkaloids cathinone, cathine and norephedrine. Two Celastraceae species, in addition to qat, have been noted for their stimulant properties in ethnobotanical literature. Recent phylogenetic reconstructions place four genera in a clade sister to Catha edulis, and these genera are primary candidates to search for cathine and related alkaloids. OBJECTIVE: Determine if cathine or related alkaloids are present in species of Celastraceae other than Catha edulis...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28058460/-risk-assessment-of-synephrine-in-dietary-supplements
#9
Nadiya Bakhyia, Birgit Dusemund, Klaus Richter, Oliver Lindtner, Karen Ildico Hirsch-Ernst, Bernd Schäfer, Alfonso Lampen
Synephrine is a sympathomimetic phenylethylamine derivative that occurs naturally in citrus fruits. It is often added to dietary supplements intended for weight loss and enhancement of sports performance, typically in the form of Citrus aurantium extracts and in many cases in combination with caffeine. The health risks of synephrine were evaluated on the basis of the available toxicological data and in accordance to the EFSA guidance on the safety assessment of botanicals and botanical preparations intended for use in food supplements...
January 5, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28049528/improvement-of-whole-cell-transamination-with-saccharomyces-cerevisiae-using-metabolic-engineering-and-cell-pre-adaptation
#10
Nora Weber, Marie Gorwa-Grauslund, Magnus Carlquist
BACKGROUND: Whole-cell biocatalysis based on metabolically active baker's yeast with engineered transamination activity can be used to generate molecules carrying a chiral amine moiety. A prerequisite is though to express efficient ω-transaminases and to reach sufficient intracellular precursor levels. RESULTS: Herein, the efficiency of three different ω-transaminases originating from Capsicum chinense, Chromobacterium violaceum, and Ochrobactrum anthropi was compared for whole-cell catalyzed kinetic resolution of racemic 1-phenylethylamine to (R)-1-phenylethylamine...
January 3, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28002512/pharmacotoxicological-screening-on-new-derivatives-of-beta-phenylethylamine-potential-agonists-of-beta3-adrenergic-receptors
#11
Simona Negreş, Anca Zanfirescu, Floriana Elvira Ionică, Elena Moroşan, Bruno Ştefan Velescu, Oana Cristina Şeremet, Cristina Elena Zbârcea, Emil Ştefănescu, Manuella Militaru, Andreea LetiŢia Arsene, Denisa Marilena Margină, Livia Uncu, Corina Scutari, Cornel ChiriŢă
BACKGROUND AND AIMS: Beta3-adrenergic receptors (beta3-ARs) have been initially characterized in 1989. Afterwards, their tissue distribution was established: white and brown adipose tissue, central nervous system, myocardium (atrial and ventricular), blood vessels, smooth gastrointestinal muscles (stomach, small intestine, colon), gallbladder, urinary bladder, prostate, skeletal muscles. Non-clinical trials have demonstrated the major implication of beta3-ARs in glucose metabolism, implicitly, in insulin release, and also in obesity...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27968713/a-new-multiresponse-optimization-approach-in-combination-with-a-d-optimal-experimental-design-for-the-determination-of-biogenic-amines-in-fish-by-hplc-fld
#12
A Herrero, S Sanllorente, C Reguera, M C Ortiz, L A Sarabia
A new strategy to approach multiresponse optimization in conjunction to a D-optimal design for simultaneously optimizing a large number of experimental factors is proposed. The procedure is applied to the determination of biogenic amines (histamine, putrescine, cadaverine, tyramine, tryptamine, 2-phenylethylamine, spermine and spermidine) in swordfish by HPLC-FLD after extraction with an acid and subsequent derivatization with dansyl chloride. Firstly, the extraction from a solid matrix and the derivatization of the extract are optimized...
November 16, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27905516/discovery-and-structural-characterisation-of-new-fold-type-iv-transaminases-exemplify-the-diversity-of-this-enzyme-fold
#13
Tea Pavkov-Keller, Gernot A Strohmeier, Matthias Diepold, Wilco Peeters, Natascha Smeets, Martin Schürmann, Karl Gruber, Helmut Schwab, Kerstin Steiner
Transaminases are useful biocatalysts for the production of amino acids and chiral amines as intermediates for a broad range of drugs and fine chemicals. Here, we describe the discovery and characterisation of new transaminases from microorganisms which were enriched in selective media containing (R)-amines as sole nitrogen source. While most of the candidate proteins were clearly assigned to known subgroups of the fold IV family of PLP-dependent enzymes by sequence analysis and characterisation of their substrate specificity, some of them did not fit to any of these groups...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827999/synthesis-of-optically-active-poly-diphenylacetylene-s-using-polymer-reactions-and-an-evaluation-of-their-chiral-recognition-abilities-as-chiral-stationary-phases-for-hplc
#14
Katsuhiro Maeda, Miyuki Maruta, Yuki Sakai, Tomoyuki Ikai, Shigeyoshi Kanoh
A series of optically active poly(diphenylacetylene) derivatives bearing a chiral substituent (poly-2S) or chiral and achiral substituents (poly-(2Sx-co-31-x)) on all of their pendant phenyl rings were synthesized by the reaction of poly(bis(4-carboxyphenyl)acetylene) with (S)-1-phenylethylamine ((S)-2) or benzylamine (3) in the presence of a condensing reagent. Their chiroptical properties and chiral recognition abilities as chiral stationary phases (CSPs) for high-performance liquid chromatography (HPLC) were investigated...
November 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27776641/synthesis-of-novel-chiral-imidazolium-stationary-phases-and-their-enantioseparation-evaluation-by-high-performance-liquid-chromatography
#15
Tao Wang, Haiyan Yang, Ruchen Qiu, Shaohua Huang
Two novel chiral stationary phases (CSPs) were prepared by bonding chiral imidazoliums on the surface of silica gel. The chiral imidazoles were derivatized from chiral amines, 1-phenylethylamine and 1-(1-naphthyl)ethylamine. The obtained CSPs were characterized by Fourier Transform Infrared (FT-IR) spectroscopy and elemental analysis (EA), demonstrating the bonding densities of CSP 1 and CSP 2 were 0.43 mmol g(-1) and 0.40 mmol g(-1), respectively. These two CSPs could be used to availably separate 8 pharmaceuticals, 7 mandelic acid/its derivatives, 2 1-phenylethylamine derivatives, 1 1,1'-bi-2-naphthol, and 1 camphorsulfonic acid in high-performance liquid chromatography (HPLC)...
November 9, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27775356/optical-activity-and-optical-anisotropy-in-photomechanical-crystals-of-chiral-salicylidenephenylethylamines
#16
Akifumi Takanabe, Masahito Tanaka, Kohei Johmoto, Hidehiro Uekusa, Tadashi Mori, Hideko Koshima, Toru Asahi
Introducing chirality into photomechanical crystals is beneficial for the diversification of mechanical motion. Measurement of the chiroptical and optical anisotropic properties of chiral crystals is indispensable for evaluating photomechanical crystals. The platelike crystals of S- and R-enantiomers of photochromic N-3,5-di-tert-butylsalicylidene-1-phenylethylamine in enol form (enol-(S)-1 and enol-(R)-1) caused bending motion with twisting upon ultraviolet (UV) light irradiation, due to shrinkage along the length and width directions of the irradiated surface, based on the optimized crystal structure of the photoisomerized trans-keto-(S)-1...
November 16, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27722329/infrared-spectrum-of-the-cold-ortho-fluorinated-protonated-neurotransmitter-2-phenylethylamine-competition-between-nh-%C3%AF-and-nh-f-interactions
#17
Markus Schütz, Aude Bouchet, Otto Dopfer
Halogenation of pharmaceutical molecules is a common tool to modify their physiological properties. The geometric, vibrational, and electronic properties of the ortho-fluorinated protonated neurotransmitter 2-phenylethylamine (oF-H(+)PEA) are characterized by infrared photodissociation (IRPD) spectroscopy in the NH stretch range using the messenger technique and dispersion-corrected density functional theory calculations at the B3LYP-D3/aug-cc-pVTZ level to elucidate the drastic effect of site-specific ortho-fluorination...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27650312/highly-productive-and-enantioselective-enzyme-catalysis-under-continuous-supported-liquid-liquid-conditions-using-a-hybrid-monolithic-bioreactor
#18
Bernhard Sandig, Michael R Buchmeiser
Enzyme-containing ionic liquids (ILs) were immobilized in cellulose-2.5-acetate microbeads particles embedded in a porous monolithic polyurethane matrix. This bioreactor was used under continuous liquid-liquid conditions by dissolving the substrates in a nonpolar organic phase immiscible with the ILs, thereby creating a biphasic system. Lipases (candida antarctica lipase B, CALB, candida rugosa lipase, CRL) were used to catalyze the enantioselective transesterification of racemic (R,S)-1-phenylethanol with vinyl butyrate and vinyl acetate, the esterification of (+/-)-2-isopropyl-5-methylcyclohexanol with propionic anhydride and the amidation of (R,S)-1-phenylethylamine with ethyl methoxyacetate...
September 21, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27637883/selection-of-amine-oxidizing-dairy-lactic-acid-bacteria-and-identification-of-the-enzyme-and-gene-involved-in-the-decrease-of-biogenic-amines
#19
Rosa Guarcello, Maria De Angelis, Luca Settanni, Sabino Formiglio, Raimondo Gaglio, Fabio Minervini, Giancarlo Moschetti, Marco Gobbetti
Accumulation of biogenic amines (BAs) in cheese and other foods is a matter of public health concern. The aim of this study was to identify the enzyme activities responsible for BA degradation in lactic acid bacteria which were previously isolated from traditional Sicilian and Apulian cheeses. The selected strains would control the concentration of BAs during cheese manufacture. First, 431 isolates not showing genes encoding the decarboxylases responsible for BA formation were selected using PCR-based methods...
December 1, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27624853/tyrosine-decarboxylase-activity-of-enterococcus-mundtii-new-insights-into-phenotypic-and-genetic-aspects
#20
Veronica Gatto, Giulia Tabanelli, Chiara Montanari, Valentina Prodomi, Eleonora Bargossi, Sandra Torriani, Fausto Gardini
Few information is available about the tyraminogenic potential of the species Enterococcus mundtii. In this study, two plant-derived strains of E. mundtii were selected and investigated to better understand the phenotypic behaviour and the genetic mechanisms involved in tyramine accumulation. Both the strains accumulated tyramine from the beginning of exponential phase of growth, independently on the addition of tyrosine to the medium. The strains accumulated also 2-phenylethylamine, although with lower efficiency and in greater extent when tyrosine was not added...
September 14, 2016: Microbial Biotechnology
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