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https://www.readbyqxmd.com/read/29453991/identification-of-branched-chain-amino-acid-aminotransferases-active-towards-r-1-phenylethylamine-among-plp-fold-type-iv-transaminases
#1
Ekaterina Yu Bezsudnova, Daria V Dibrova, Alena Yu Nikolaeva, Tatiana V Rakitina, Vladimir O Popov
New class IV transaminases with activity towards L-Leu, which is typical of branched-chain amino acid aminotransferases (BCAT), and with activity towards (R)-(+)-1-phenylethylamine ((R)-PEA), which is typical of (R)-selective (R)-amine:pyruvate transaminases, were identified by bioinformatics analysis, obtained in recombinant form, and analyzed. The values of catalytic activities in the reaction with L-Leu and (R)-PEA are comparable to those measured for characteristic transaminases with the corresponding specificity...
February 14, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29423216/dietary-proline-supplementation-alters-colonic-luminal-microbiota-and-bacterial-metabolite-composition-between-days-45-and-70-of-pregnancy-in-huanjiang-mini-pigs
#2
Yujiao Ji, Qiuping Guo, Yulong Yin, Francois Blachier, Xiangfeng Kong
Background: Pregnancy is associated with important changes in gut microbiota composition. Dietary factors may affect the diversity, composition, and metabolic activity of the intestinal microbiota. Among amino acids, proline is known to play important roles in protein metabolism and structure, cell differentiation, conceptus growth and development, and gut microbiota re-equilibration in case of dysbiosis. Results: Dietary supplementation with 1% proline decreased (P < 0...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29412921/profiling-wines-in-china-for-the-biogenic-amines-a-nationwide-survey-and-pharmacokinetic-fate-modelling
#3
Runhui Ke, Zongsu Wei, Christian Bogdal, Recep Kaya Göktaş, Ruiyang Xiao
Biogenic amines (BAs), a class of nitrogenous compounds that are frequently detected in wine, pose adverse effects to humans. However, with the largest red wine consumption in the world, little is known about national profiles correlating BAs in wines to toxicological/health risks in China. In this study, we conducted a nationwide survey of commercially available wines for the occurrence of BAs. Our sampling campaign covered >90% of wine brands (n = 456) in China in a three year span (2014-2016). The target BAs included tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29409596/thermodynamics-of-acid-base-dissociation-of-several-cathinones-and-1-phenylethylamine-studied-by-an-accurate-capillary-electrophoresis-method-free-from-the-joule-heating-impact
#4
Paweł Mateusz Nowak, Michał Woźniakiewicz, Mariusz Mitoraj, Filip Sagan, Paweł Kościelniak
Capillary electrophoresis is often used to the determination of the acid-base dissociation/deprotonation constant (pKa), and the more advanced thermodynamic quantities describing this process (ΔH°, -TΔS°). Remarkably, it is commonly overlooked that due to insufficient dissipation of Joule heating the accuracy of parameters determined using a standard approach may be questionable. In this work we show an effective method allowing to enhance reliability of these parameters, and to estimate the magnitude of errors...
February 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29401260/intraspecies-polymorphisms-of-kluyveromyces-marxianus-strains-from-yaghnob-valley
#5
Perpetuini Giorgia, Tittarelli Fabrizia, Mattarelli Paola, Modesto Monica, Cilli Elisabetta, Suzzi Giovanna, Tofalo Rosanna
In this study, 29 strains of Kluyveromyces marxianus with peculiar genetic and phenotypic traits previously isolated from a fermented goat milk of Yaghnob valley were investigated for chromosome length polymorphism (CLP) by PFGE, adhesion properties and carbon usage by Biolog analysis. Obtained data showed that strains differed in terms of number and size of chromosome bands. The number of bands ranged from 5 to 7, suggesting a probable genome size from 1.4 to 2.6 Mb. Strains showed a certain level of cell surface hydrophobicity ranging from 32% to 77...
February 1, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29367643/characterization-of-dopaminergic-system-in-the-striatum-of-young-adult-park2-knockout-rats
#6
Jickssa M Gemechu, Akhil Sharma, Dongyue Yu, Yuran Xie, Olivia M Merkel, Anna Moszczynska
Mutations in parkin gene (Park2) are linked to early-onset autosomal recessive Parkinson's disease (PD) and young-onset sporadic PD. Park2 knockout (PKO) rodents; however, do not display neurodegeneration of the nigrostriatal pathway, suggesting age-dependent compensatory changes. Our goal was to examine dopaminergic (DAergic) system in the striatum of 2 month-old PKO rats in order to characterize compensatory mechanisms that may have occurred within the system. The striata form wild type (WT) and PKO Long Evans male rats were assessed for the levels of DAergic markers, for monoamine oxidase (MAO) A and B activities and levels, and for the levels of their respective preferred substrates, serotonin (5-HT) and ß-phenylethylamine (ß-PEA)...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29360121/why-does-the-y326i-mutant-of-monoamine-oxidase-b-decompose-an-endogenous-amphetamine-at-a-slower-rate-than-the-wild-type-enzyme-reaction-step-elucidated-by-multiscale-molecular-simulations
#7
Domen Pregeljc, Urška Jug, Janez Mavri, Jernej Stare
This work investigates the Y326I point mutation effect on the kinetics of oxidative deamination of phenylethylamine (PEA) catalyzed by the monoamine oxidase B (MAO B) enzyme. PEA is a neuromodulator capable of affecting the plasticity of the brain and is responsible for the mood enhancing effect caused by physical exercise. Due to a similar functionality, PEA is often regarded as an endogenous amphetamine. The rate limiting step of the deamination was simulated at the multiscale level, employing the Empirical Valence Bond approach for the quantum treatment of the involved valence states, whereas the environment (solvated protein) was represented with a classical force field...
January 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29326984/using-parahydrogen-to-hyperpolarize-amines-amides-carboxylic-acids-alcohols-phosphates-and-carbonates
#8
Wissam Iali, Peter J Rayner, Simon B Duckett
Hyperpolarization turns weak nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) responses into strong signals, so normally impractical measurements are possible. We use parahydrogen to rapidly hyperpolarize appropriate 1H, 13C, 15N, and 31P responses of analytes (such as NH3) and important amines (such as phenylethylamine), amides (such as acetamide, urea, and methacrylamide), alcohols spanning methanol through octanol and glucose, the sodium salts of carboxylic acids (such as acetic acid and pyruvic acid), sodium phosphate, disodium adenosine 5'-triphosphate, and sodium hydrogen carbonate...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29234054/antagonistic-effect-of-dopamine-structural-analogues-on-human-gaba%C3%AF-1-receptor
#9
Alfredo Alaniz-Palacios, Ataulfo Martínez-Torres
GABAergic and dopaminergic pathways are co-localized in several areas of the central nervous system and recently several reports have shown co-release of both neurotransmitters. The GABA-A receptor (β and ρ1 subunits) is modulated by dopamine (DA) and, interestingly, GABAρ1 can be modulated by several biogenic amines. Here we explored the effects of the metabolites of the dopaminergic pathway and other structural analogues of DA on GABAρ1 and the DA gated ion channel (LGC-53) from Caenorhabditis elegans expressed in Xenopus laevis oocytes...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228118/where-is-the-tmt-gc-ms-analyses-of-fox-feces-and-behavioral-responses-of-rats-to-fear-inducing-odors
#10
Olivier Rampin, Nathalie Jerôme, Audrey Saint-Albin, Christian Ouali, Frank Boué, Nicolas Meunier, Birte L Nielsen
TMT (2,5-dihydro-2,4,5-trimethylthiazoline) is known as a component of fox feces inducing fear in rodents. However, no recent chemical analyses of fox feces are available, and few studies make direct comparisons between TMT and fox feces. Fox feces from 3 individuals were used to prepare 24 samples to be analyzed for the presence of TMT using gas chromatography-mass spectrometry (GC-MS). When TMT was added in low amounts (50-2000 nmol/g), TMT was detected in 10 out of 11 samples. When no TMT was added, TMT was detected in only 1 out of 13 samples...
December 8, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29202379/platelet-monoamine-oxidase-activity-and-interpersonal-violence-in-male-suicide-attempters
#11
Jussi Jokinen, Johan Königsson, Tomas Moberg, Erik G Jönsson, Jari Tiihonen, Peter Nordström, Lars Oreland, Marie Åsberg
Low platelet monoamine oxidase B (MAO-B) activity, proxy of low central serotonergic functions, has been shown to correlate with criminal behavior in adolescents that come from an unfavorable psychosocial environment but not in adolescents from good conditions, indicating a link between environment, MAO-B activity and aggressive behavior. The purpose of this study was to examine the association between MAO-B activity and lifetime interpersonal violence in suicide attempters. The study included a total of 28 suicide attempters (18 men and 10 women)...
November 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29116873/the-effect-of-experimental-supplementation-with-the-klamath-algae-extract-klamin-on-attention-deficit-hyperactivity-disorder
#12
Maurizio Cremonte, Davide Sisti, Ilaria Maraucci, Simona Giribone, Evelin Colombo, Marco Bruno Luigi Rocchi, Stefano Scoglio
Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological condition with onset in childhood. The disorder is characterized by inattention, impulsivity, and/or motor hyperactivity, which often affect the development and social integration of affected subjects. Phenylethylamine (PEA), naturally contained in the Klamath Lake microalgae and concentrated in the Klamin® extract, is an endogenous molecule with a general neuromodulatory activity. It functions as an activator for the neurotransmission of dopamine and other catecholamines, and very low concentrations of PEA may be associated with specific psychological disorders such as ADHD...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29074414/non-adrenergic-vasoconstriction-and-vasodilatation-of-guinea-pig-aorta-by-%C3%AE-phenylethylamine-and-amphetamine-role-of-nitric-oxide-determined-with-l-name-and-no-scavengers
#13
Kenneth J Broadley, Harrison D Broadley
Sympathomimetic and trace amines, including β-phenylethylamine (PEA) and amphetamine, increase blood pressure and constrict isolated blood vessels. By convention this is regarded as a sympathomimetic response, however, recent studies suggest trace amine-associated receptor (TAAR) involvement. There is also uncertainty whether these amines also release nitric oxide (NO) causing opposing vasodilatation. These questions were addressed in guinea-pig isolated aorta, a species not previously examined. Guinea-pig aortic rings were set up to measure contractile tension...
October 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28967251/total-synthesis-of-dendrochrysanene-through-a-frame-rearrangement
#14
Naoki Katsuki, Shumpei Isshiki, Daisuke Fukatsu, Juan Okamura, Kouji Kuramochi, Takeo Kawabata, Kazunori Tsubaki
The first total synthesis of dendrochrysanene (1) was achieved. The key reaction for the construction of dendrochrysanene was an oxidative frame rearrangement reaction from a phenanthrene dimer to a spiro-lactone skeleton, which we serendipitously identified. Owing to the steric hindrance of the substituent on the peri position of the phenanthrene dimer, high-temperature conditions were required for the rearrangement reaction; however, at such temperatures, the substrate decomposed. To address this issue, we added phenylethylamine or benzylamine to the reaction system...
October 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28873563/application-of-3-5-bis-trifluoromethyl-phenyl-isothiocyanate-for-the-determination-of-selected-biogenic-amines-by-lc-tandem-mass-spectrometry-and-19-f-nmr
#15
Aneta Jastrzębska, Anna Piasta, Marek Krzemiński, Edward Szłyk
3,5-Bis-(trifluoromethyl)phenyl isothiocyanate, was used as a convenient reagent for the derivatization of histamine, tyramine, tryptamine and 2-phenylethylamine, which eliminates the purification step. The obtained derivatives were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Additionally, the total amount of these amines was determined by (19)F nuclear magnetic resonance analysis. The procedures were optimized and validated for linearity, limit of detection and quantification, intra- and inter-day precision and recovery resulting in good reproducibility and accuracy...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28873546/reduction-of-biogenic-amines-in-sufu-by-ethanol-addition-during-ripening-stage
#16
Shuang Qiu, Ying Wang, Yongqiang Cheng, Yan Liu, Madhav P Yadav, Lijun Yin
The aim of this study was to investigate the content of biogenic amines (BAs) in different types of sufu samples obtained from different producers, and the effect of ethanol in reducing BA levels during sufu ripening. The results showed that different manufacturing processes altered the distribution of BAs in commercial sufu. Putrescine, cadaverine, histamine, and tryptamine were the main and common BAs in red, white and grey sufu. The contents of putrescine, cadaverine, tryptamine, β-phenylethylamine and tyramine in the grey sufu of all producer brands were significantly (p<0...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28841190/alkaloids-from-oxytropis-myriophylla-pall-dc
#17
Keisuke Kojima, Purevsuren S, Narantuya S, Tsetsegmaa S, Jamyansan Ya, Kimio Lsaka, Yukio Ogihara
Five alkaloids were isolated from the epigeal part of Oxytropis myriophylla. Three alkaloids were identified as N-benzoyl-β-phenylethylamine, N-trans-cinnamoyl-β-phenylethylamine, N-cis-cinnamoyl-β-phenylethylamine and the structures of two new alkaloids were elucidated to be N-benzoyl-β-hydroxyphenylethylarnine(2), N-trans-cinnamoyl-β-hydroxy-phenylethylamine(5). The absolu.te structures were established by modified Mosher method.
August 25, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28738644/biosensor-for-the-characterisation-of-hmao-b-inhibitors-and-the-quantification-of-selegiline
#18
Maximilian Aigner, Patricia Preissegger, Kurt Kalcher, Eda Mehmeti, Peter Macheroux, Dale Edmondson, Astrid Ortner
A novel human monoamine oxidase B (hMAO B) based biosensor for inhibitory measurements was developed. It allows both the characterisation of the type of enzyme inhibition and the sensitive and simple determination of inhibitors like selegiline hydrochloride. The sensor consists of a screen printed carbon working electrode modified with 20% manganese dioxide (MnO2) and the enzyme hMAO B, which was immobilised on the electrode via a dialysis membrane (regenerated cellulose, molecular weight cut-off 14000). Inhibition of hMAO B is evaluated by adding different concentrations of the inhibitor selegiline hydrochloride to the enzyme and applying a defined amount of the hMAO B substrate phenylethylamine (PEA)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28706468/retinal-metabolic-events-in-preconditioning-light-stress-as-revealed-by-wide-spectrum-targeted-metabolomics
#19
Juan Manuel Chao de la Barca, Nuan-Ting Huang, Haihan Jiao, Lydie Tessier, Cédric Gadras, Gilles Simard, Riccardo Natoli, Guillaume Tcherkez, Pascal Reynier, Krisztina Valter
INTRODUCTION: Light is the primary stimulus for vision, but may also cause damage to the retina. Pre-exposing the retina to sub-lethal amount of light (or preconditioning) improves chances for retinal cells to survive acute damaging light stress. OBJECTIVES: This study aims at exploring the changes in retinal metabolome after mild light stress and identifying mechanisms that may be involved in preconditioning. METHODS: Retinas from 12 rats exposed to mild light stress (1000 lux × for 12 h) and 12 controls were collected one and seven days after light stress (LS)...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28675687/disruptive-physiology-olfaction-and-the-microbiome-gut-brain-axis
#20
John Bienenstock, Wolfgang A Kunze, Paul Forsythe
This review covers the field of olfaction and chemosensation of odorants and puts this information into the context of interactions between microbes and behaviour; the microbiome-gut-brain axis (MGBA). Recent emphasis has also been placed on the concept of the holobiome which states that no single aspect of an organism should be viewed separately and thus must include examination of their associated microbial populations and their influence. While it is known that the microbiome may be involved in the modulation of animal behaviour, there has been little systematized effort to incorporate into such studies the rapidly developing knowledge of the wide range of olfactory systems...
July 4, 2017: Biological Reviews of the Cambridge Philosophical Society
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