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https://www.readbyqxmd.com/read/27901512/mitochondrial-dysfunction-in-alveolar-and-white-matter-developmental-failure-in-premature-infants
#1
Vadim S Ten
At birth, some organs in premature infants are not developed enough to meet challenges of the extra-uterine life. Although growth and maturation continues after premature birth, postnatal organ development may become sluggish or even arrested, leading to organ dysfunction. There is no clear mechanistic concept of this postnatal organ developmental failure in premature neonates. This review introduces a concept-forming hypothesis: Mitochondrial bioenergetic dysfunction is a fundamental mechanism of organs maturation failure in premature infants...
November 30, 2016: Pediatric Research
https://www.readbyqxmd.com/read/26779382/omeprazole-does-not-potentiate-acute-oxygen-toxicity-in-fetal-human-pulmonary-microvascular-endothelial-cells-exposed-to-hyperoxia
#2
Ananddeep Patel, Shaojie Zhang, Bhagavatula Moorthy, Binoy Shivanna
Hyperoxia contributes to the pathogenesis of broncho-pulmonary dysplasia (BPD), which is a developmental lung disease of premature infants that is characterized by an interruption of lung alveolar and pulmonary vascular development. Omeprazole (OM) is a proton pump inhibitor that is used to treat humans with gastric acid related disorders. Earlier we observed that OM-mediated aryl hydrocarbon receptor (AhR) activation attenuates acute hyperoxic lung injury in adult mice and oxygen toxicity in adult human lung cells...
October 2015: Pharmaceutica Analytica Acta
https://www.readbyqxmd.com/read/25760835/-what-is-the-optimal-oxygen-saturation-for-extremely-premature-infants-a-meta-analysis
#3
Jing-Yang Li, Zhen-Lang Lin, Jia Wei, Yan-Yan Yan, Jin Lin
OBJECTIVE: To explore an optimal oxygen saturation for extremely preterm infants based on a systemic review of the published studies. METHODS: A Meta analysis of the published studies by the NeOProM Group which compared the outcomes of extremely preterm infants (gestational age <28 weeks) maintained in either a low (85%-89%) or high (91%-95%) oxygen saturation (SpO2) by using the STATA 12.0. The outcomes measured included the mortality and the incidences of retinopathy of prematurity (ROP), necrotizing enterocolitis of newborn (NEC), broncho-pulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) and patent ductus arteriosus (PDA)...
February 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25622597/haemoglobin-level-at-birth-is-associated-with-short-term-outcomes-and-mortality-in-preterm-infants
#4
Jayanta Banerjee, Felix K Asamoah, Devpriya Singhvi, Angela W G Kwan, Joan K Morris, Narendra Aladangady
BACKGROUND: Blood volume and haemoglobin (Hb) levels are increased by delayed umbilical cord clamping, which has been reported to improve clinical outcomes of preterm infants. The objective was to determine whether Hb level at birth was associated with short term outcomes in preterm infants born at ≤32 weeks gestation. METHODS: Data were collected retrospectively from electronic records: Standardised Electronic Neonatal Database, Electronic Patient Record, Pathology (WinPath), and Blood Bank Electronic Database...
2015: BMC Medicine
https://www.readbyqxmd.com/read/25578394/exome-sequencing-and-pathway-analysis-for-identification-of-genetic-variability-relevant-for-bronchopulmonary-dysplasia-bpd-in-preterm-newborns-a-pilot-study
#5
Paola Carrera, Chiara Di Resta, Chiara Volonteri, Emanuela Castiglioni, Silvia Bonfiglio, Dejan Lazarevic, Davide Cittaro, Elia Stupka, Maurizio Ferrari, Marco Somaschini
BACKGROUND: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infancy, affecting preterm children with low birth weight. The disease has a multifactorial aetiology with a significant genetic component; until now published association studies have identified several candidate genes but only few of these data has been replicated. In this pilot study, we approached exome sequencing aimed at identifying non-common variants, which are expected to have a stronger phenotypic effect...
December 7, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/25149882/comparison-of-insure-method-with-conventional-mechanical-ventilation-after-surfactant-administration-in-preterm-infants-with-respiratory-distress-syndrome-therapeutic-challenge
#6
RANDOMIZED CONTROLLED TRIAL
Fatemeh Sadat Nayeri, Tahereh Esmaeilnia Shirvani, Majid Aminnezhad, Elaheh Amini, Hossein Dalili, Faezeh Moghimpour Bijani
Administration of endotracheal surfactant is potentially the main treatment for neonates suffering from RDS (Respiratory Distress Syndrome), which is followed by mechanical ventilation. Late and severe complications may develop as a consequence of using mechanical ventilation. In this study, conventional methods for treatment of RDS are compared with surfactant administration, use of mechanical ventilation for a brief period and NCPAP (Nasal Continuous Positive Airway Pressure), (INSURE method ((Intubation, Surfactant administration and extubation))...
2014: Acta Medica Iranica
https://www.readbyqxmd.com/read/25094499/identifying-risk-factors-for-two-complication-types-for-neonatal-intensive-care-patients-nicu
#7
M Frize, R C Walker, D Ibrahim
This paper discusses the results of applying artificial neural networks to predicting complication for neonatal intensive care patients. Risk factors that lead to necrotizing entero-colitis or broncho-pulmonary dysplasia were identified. Future work will expand this work to other outcomes and add probability information to the estimations.
August 2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/24706414/positional-effects-on-lung-mechanics-of-ventilated-preterm-infants-with-acute-and-chronic-lung-disease
#8
V Vendettuoli, C Veneroni, E Zannin, D Mercadante, P Matassa, A Pedotti, M Colnaghi, R L Dellacà, F Mosca
BACKGROUND: The role of prone position in preterm infants has not been completely clarified. We investigated prone versus supine posture-related changes in respiratory system resistance (Rrs) and reactance (Xrs) measured by the Forced Oscillation Technique (FOT) in mechanically ventilated preterm newborns. METHODS: Patients were studied in the supine versus prone positions in random order. Oxygen saturation, transcutaneous partial pressure of oxygen (ptcO2 ), carbon dioxide (ptcCO2 ), Rrs and Xrs were measured in each position...
August 2015: Pediatric Pulmonology
https://www.readbyqxmd.com/read/24490470/-hypertensive-crisis-in-children-and-adolescents
#9
REVIEW
Piotr Skrzypczyk, Maria Roszkowska-Blaim, Maria Daniel
Hypertensive crisis is a sudden rise in blood pressure above 99 c. for sex, age and height +5 mm Hg. Depending on patient's symptoms, hypertensive crisis can be divided into hypertensive emergency severe arterial hypertension with target organ insufficiency and/r damage (central nervous system, heart, kidney, eye), and hypertensive urgency - severe arterial hypertension without target organ insufficiency and damage with non-specific symptoms like: headaches, vertigo, nasal bleeding, nausea, and vomiting. The most common causes of hypertensive crisis in neonates and infants are renal artery thrombosis, broncho-pulmonary dysplasia, and coarctation of aorta; in older children - kidney diseases and renal artery stenosis...
December 2013: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/24484390/nasal-ventilation-is-not-continuous-positive-airway-pressure-with-a-rate-but-mechanical-ventilation-without-a-tube
#10
Srinivasa Murthy Doreswamy, Prashanth Murthy
No abstract text is available yet for this article.
May 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24372946/low-risk-but-not-no-risk-of-umbilical-hernia-complications-requiring-acute-surgery-in-childhood
#11
Amanda Ireland, Ian Gollow, Parshotam Gera
AIMS: Umbilical hernias are a common finding in the paediatric community, with a preponderance to affect Afro-Caribbean and premature children. The rate of incarceration varies greatly between populations. Therefore, it is valuable to obtain some Australian data on this topic. METHODS: We undertook a retrospective study of the records of all patients who underwent umbilical hernia repair over a 12-year period of between October 1999 and May 2012 at Princess Margaret Hospital...
April 2014: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/24140977/calcium-signaling-related-proteins-are-associated-with-broncho-pulmonary-dysplasia-progression
#12
Cinzia Magagnotti, Piero Giuseppe Matassa, Angela Bachi, Valentina Vendettuoli, Isabella Fermo, Maria Rosa Colnaghi, Rose Mary Carletti, Domenica Mercadante, Elena Fattore, Fabio Mosca, Annapaola Andolfo
UNLABELLED: Broncho-pulmonary dysplasia (BPD) is a chronic pulmonary disorder that follows premature birth. It is preceded by respiratory distress syndrome (RDS), characterized by acute respiratory failure due to deficiency of surfactant at birth. Clinical characteristics of infants affected by BPD have widely changed in the last decades: they are extraordinarly immature, with impaired alveolar and vascular lung development. To build up new therapeutic strategies for BPD babies, it is necessary to understand the pathogenic mechanisms, which are complicated by environmental risk factors and genetic predisposition...
December 6, 2013: Journal of Proteomics
https://www.readbyqxmd.com/read/23714420/phthalates-in-the-nicu-is-it-safe
#13
REVIEW
Céline J Fischer, Myriam Bickle Graz, Vincent Muehlethaler, David Palmero, Jean-François Tolsa
AIMS: As growing concerns exist regarding phthalate exposure, which could be teratogenic, carcinogenic or induce reproductive toxicity, we aimed to review the evidence of the risks due to the use of medical devices containing di(2-ethylhexyl)phthalate in hospitalized neonates. METHODS: We reviewed the literature, searching through medical literature databases (Pubmed, MEDLINE, EBM reviews, Cochrane database, Embase and Google Scholar) using the following keywords: phthalate, di(2-ethylhexyl)phthalate, newborn and neonate...
September 2013: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/22916088/transcriptional-programs-controlling-perinatal-lung-maturation
#14
Yan Xu, Yanhua Wang, Valérie Besnard, Machiko Ikegami, Susan E Wert, Caleb Heffner, Stephen A Murray, Leah Rae Donahue, Jeffrey A Whitsett
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6<A/J)...
2012: PloS One
https://www.readbyqxmd.com/read/22564295/ibubrofen-in-the-treatment-of-patent-ductus-arteriosus-in-preterm-infants-what-we-know-what-we-still-do-not-know
#15
Isabelle Mercanti, Isabelle Ligi, Farid Boubred, Isabelle Grandvuillemin, Christophe Buffat, Laurance Fayol, Veronique Millet, Umberto Simeoni
The patency of the ductus arteriosus has ever been considered as a pathological situation in preterm infants and one likely cause of mortality and morbidity, including broncho-pulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity. The incidence of patent ductus arteriosus is inversely proportional to gestational age and infants with the lowest gestational ages are the most exposed to the complications of prematurity. So, associations between patent ductus arteriosus and the other morbidities may not be causative and patent ductus arteriosus could be more a sign of immaturity and severity of disease than the cause of these problems...
2012: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/22465341/value-of-herpes-simplex-virus-type-specific-serology-a-case-report
#16
J Bentley, A P Neubauer, A Sauerbrei
Genital herpes, usually caused by herpes simplex virus type 2 (HSV-2), is one of the most common sexually transmitted diseases in humans. By contrast, intrauterine HSV-2 infections have been described rarely in the literature. Our report describes a case of neonate who was delivered after 30+2 gestational weeks by cesarean section. He presented with a respiratory distress syndrome resulting in broncho-pulmonary dysplasia. At the age of 6 weeks, a chorioretinal scar was detected. During the 4th month of age, the infant developed recurrent HSV-2 infection with nasal lesions...
July 2012: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/22385060/ibubrofen-in-the-treatment-of-patent-ductus-arteriosus-in-preterm-infants-what-we-know-what-we-still-do-not-know
#17
Isabelle Mercanti, Isabelle Ligi, Farid Boubred, Isabelle Grandvuillemin, Christophe Buffat, Laurance Fayol, Véronique Millet, Umberto Simeoni
The patency of the ductus arteriosus has ever been considered as a pathological situation in preterm infants and one likely cause of mortality and morbidity, including broncho-pulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity. The incidence of patent ductus arteriosus is inversely proportional to gestational age and infants with the lowest gestational ages are the most exposed to the complications of prematurity. So, associations between patent ductus arteriosus and the other morbidities may be not causative and patent ductus arteriosus could be more a sign of immaturity and severity of disease than the cause of these problems...
February 27, 2012: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/21834608/immediate-clinical-outcomes-in-preterm-neonates-receiving-antenatal-magnesium-for-neuroprotection
#18
Sudeepta Kumar Basu, Vijay Chickajajur, Vivian Lopez, Alok Bhutada, Murali Pagala, Shantanu Rastogi
BACKGROUND: Antenatal magnesium sulfate can potentially reduce the risk of cerebral palsy in neonates delivered between 24 and 32 weeks of gestational age. Some studies using high-dose magnesium sulfate for neuroprotection have reported increased perinatal mortality. METHODS: A retrospective study was conducted on 475 neonates born between 24 and 32 weeks of gestational age. Serum magnesium level in the first 24 h of life was used to stratify the neonates treated with antenatal magnesium into four subgroups: A (<2...
August 11, 2011: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/21823361/-natural-course-of-preneoplastic-bronchial-lesions
#19
REVIEW
Ruxandra Ulmeanu, Ruxandra Râjnoveanu, Eugenia Halic, Oana Deleanu, Florin Mihălţan
Advances in endoscopic technology have improved the detection of precancerous bronchial lesions associated with the occurence of proximal squamous cell lung cancer (SCC) in high-risk individuals for broncho-pulmonary neoplasm. The debates and controversies regarding the control and treatment of intraepitelial bronchial lesions is due to the fact that the regression rate of all preneoplastic bronchial lesions is 54%. But the progression to carcinoma in situ or to cancer is significantly higher for severe dysplasia, than for preneoplastic lesions showing lower-grade dysplasia, such as squamous metaplasia and mild or moderate dysplasia...
April 2011: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/21563441/-bronchiolitis-we-don-t-know-how-to-treat-we-can-prevent
#20
REVIEW
Anna Breborowicz
Broncholitis in infant is most commonly results from viral infection, typically RS virus will be responsible. Treatment is difficult due to limited efficacy of available methods of causal and symptomatic therapies. Therefore it is specially important to seek preventive measures. This is crucial in case of preterm infants, infants with broncho-pulmonary dysplasia, cystic fibrosis, hemodynamically significant congenital heart defects and immunodeficiencies who are likely to undergo a severe course of the disease...
2011: Przegla̧d Lekarski
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