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Silymarin

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https://www.readbyqxmd.com/read/28635153/topical-silymarin-administration-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-randomized-double-blinded-placebo-controlled-clinical-trial
#1
Sepideh Elyasi, Farzaneh Sadat Rezazadeh Shojaee, Abolghasem Allahyari, Gholamreza Karimi
Hand-foot syndrome (HFS) is a frequent dose-limiting adverse reaction of capecitabine in patient with gastrointestinal cancers. Silymarin is a polyphenolic flavonoid extracted from the Silybum marianum that exhibits strong antioxidant and antiinflammatory activities. In this study, we evaluated silymarin efficacy in prevention of capecitabine-induced HFS in patients with gastrointestinal cancers, as the first human study. During this pilot, randomized, double-blinded, placebo-controlled clinical trial, the effect of silymarin gel 1%, which is applied on the palms and soles twice daily starting at the first day of chemotherapy for 9 weeks, on HFS occurrence was assessed...
June 21, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28625483/silymarin-protects-against-renal-injury-through-normalization-of-lipid-metabolism-and-mitochondrial-biogenesis-in-high-fat-fed-mice
#2
Bin Feng, Ran Meng, Bin Huang, Yan Bi, Shanmei Shen, Dalong Zhu
Obesity is associated with an increased risk of chronic kidney diseases and the conventional treatment with renin-angiotensin-aldosterone system (RAAS) inhibitors is not enough to prevent renal injury and prolong the progression of disease. Recently, silymarin has shown protective effects on renal tissue injury, but the underlying mechanisms remain elusive. The goal of this study was to investigate the potential capacity of silymarin to prevent renal injury during obesity induced by high fat diet (HFD) in mice...
June 15, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28616927/-technology-and-methodssimultaneous-determination-of-9-natural-ingredientsin-functional-food-for-anti-hangover-and-hepatoprotection-by-high-performance-liquid-chromatography
#3
Hai-Min Zou, Chen Zhou, Cheng-Jun Sun, Yong-Xin Li, Xiao-Song Yang, Jun Wen, Hong-Yan Zeng
OBJECTIVES: To develop a rapid method of high performance liquid chromatography coupled with variable wave length UV detection for simultaneous determination of 9 natural functional ingredients including puerarin, silymarin, quercetin hydrate, schisandrol A, curcumin, tanshinoneI, tanshinoneIIA, cryptotanshinone, and dihydrotanshinoneIin functional food for anti-hangover and hepatoprotection. METHODS: The samples were ultrasonically extracted with 90 % ethanol (V/V) and centrifuged at 10 000 r/min for 10 min prior to HPLC analysis...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28606074/modulatory-influence-of-acacia-hydaspica-r-parker-ethyl-acetate-extract-against-cisplatin-inveigled-hepatic-injury-and-dyslipidemia-in-rats
#4
Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan
BACKGROUND: Cisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity. METHODS: Rats were randomly separated into six groups (n = 6)...
June 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28603098/comparison-of-efficacy-of-folic-acid-and-silymarin-in-the-management-of-antiepileptic-drug-induced-liver-injury-a-randomized-clinical-trial
#5
Masoumeh Asgarshirazi, Mamak Shariat, Mahdi Sheikh
BACKGROUND: Liver injury associated with antiepileptic drugs accounts for a large proportion of drug-induced liver injuries (DILI) in children. Although withdrawal of the causative agent is the only proved treatment for DILI, in some clinical situations it is not possible. Recent studies have reported promising results of using hepatoprotective drugs with antioxidant actions for the management of DILI. This study aimed to evaluate the efficacy of folic acid versus silymarin treatment in relation to decreasing liver enzymes in patients with DILI due to antiepileptic therapy...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28602600/influence-of-the-dual-combination-of-silymarin-and-epigallocatechin-gallate-natural-dietary-flavonoids-on-the-pharmacokinetics-of-oxcarbazepine-in-rats
#6
Ana Ferreira, Márcio Rodrigues, Alexandre Marques, Amílcar Falcão, Gilberto Alves
Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)-mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC). Rats were pre-treated intraperitoneally with silymarin (25 mg/kg), EPG (25 mg/kg), silymarin/EPG (12.5/12.5 mg/kg; 6.25/18.75 mg/kg; 18.75/6.25 mg/kg) or verapamil (25 mg/kg, reference P-gp inhibitor) before the intraperitoneal administration of OXC (50 mg/kg)...
June 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28602599/silibinin-inhibits-the-fibrotic-responses-induced-by-cigarette-smoke-via-suppression-of-tgf-%C3%AE-1-smad-2-3-signaling
#7
Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, In-Chul Lee, Jung-Min Ryu, Ha-Jung Kim, Young-Kwon Cho, Jong-Choon Kim, In-Sik Shin
Cigarette smoke (CS) is generally accepted as a major contributor to chronic obstructive pulmonary disease (COPD) which is characterized by chronic inflammation, fibrotic response, and airway obstruction. In this study, we investigated the preventive effects of silibinin, an active constitute of silymarin on CS and lipopolysaccharide (LPS) exposure-induced fibrotic response. Mice were exposed to CS for 1 h per day (8 cigarettes per day) for 4 weeks. On day 12 and 26, mice were treated with LPS intranasally...
June 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28601050/inhibition-of-apoptosis-and-proliferation-in-t-cells-by-immunosuppressive-silymarine
#8
Ehsan Almasi, Marjan Gharagozloo, Nahid Eskandari, Afshin Almasi, Ali Mohammad Sabzghabaee
Silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. The aim of this study was to compare effects of Silymarin, Rapamycin and FK506 on proliferation and apoptosis of human T cells stimulated with Con A. Peripheral blood mononuclear cells (PBMC) were stimulated with concavalin A (Con A) (5µg/mL) and then treated with different inhibitors (silymarin, rapamycin and FK506) in various concentrations (5 days). Cells were examined using carboxyfluorescein succinimidyl ester (CFSE) assay for proliferation...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28601049/silymarin-livergol%C3%A2-decreases-disease-activity-score-in-patients-with-rheumatoid-arthritis-a-non-randomized-single-arm-clinical-trial
#9
Mehrdad Shavandi, Ali Moini, Yadollah Shakiba, Ahamad Mashkorinia, Milad Dehghani, Shirin Asar, Amir Kiani
Rheumatoid arthritis (RA) is a chronic autoimmune disease, which can lead to joint destruction and disability. Pannus formation due to chronic synovitis is the hallmark of RA. Oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. Silymarin, an antioxidant extract from Silybum marianum, has been traditionally used for the treatment of liver diseases for decades. In the present non-randomized single-arm clinical trial (NRSACT) study we evaluated the effects of silymarin tablet (Livergol®) on inflammatory markers in stable RA patients...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28599245/anti-inflammatory-and-ameliorative-effects-of-gallic-acid-on-fluoxetine-induced-oxidative-stress-and-liver-damage-in-rats
#10
Omid Karimi-Khouzani, Esfandiar Heidarian, Sayed Asadollah Amini
BACKGROUND: Fluoxetine-induced liver damage is a cause of chronic liver disease. In the present study the hepatoprotective effects of gallic acid against fluoxetine-induced liver damage were examined. METHODS: Forty-eight male rats were divided into six groups as follow: group 1, the control group; group 2, rats receiving fluoxetine (24mg/kg bw daily, po) without treatment; group 3, rats receiving 24mg/kg bw fluoxetine, treated with 50mg/kg bw silymarin and groups 4, 5, and 6 in which gallic acid (50, 100, and 200mg/kg bw, po, respectively) was prescribed after the consumption of fluoxetine...
March 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28587348/hepatoprotective-effects-of-litchi-litchi-chinensis-procyanidin-a2-on-carbon-tetrachloride-induced-liver-injury-in-icr-mice
#11
Lih-Geeng Chen, Cheng-Wei Chang, Jwu-Guh Tsay, Brian Bor-Chun Weng
Drug tolerance, lacking liver regenerative activity and inconclusive inhibition of steatosis and cirrhosis by silymarin treatment during chronic liver injury have increased the demand for novel alternative or synergistic treatments for liver damage. Litchi fruit is abundant in polyphenolic compounds and is used in traditional Chinese medicine for treatments that include the strengthening of hepatic and pancreatic functions. Unique polyphenolic compounds obtained from litchi pericarp extract (LPE) were studied in vitro and in vivo for hepatoprotection...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28573237/protective-effect-of-moringa-peregrina-leaves-extract-on-acetaminophen-induced-liver-toxicity-in-albino-rats
#12
Samy Abdelfatah Abdel Azim, Mohamed Taha Abdelrahem, Mostafa Mohamed Said, Alshaimaa Khattab
BACKGROUND: Acetaminophen is a common antipyretic drug but at overdose can cause severe hepatotoxicity that may further develop into liver failure and hepatic centrilobular necrosis in experimental animals and humans. This study was undertaken to assess the ameliorative role of Moringa peregrina leaves extract against acetaminophen toxicity in rats. MATERIALS AND METHODS: Induction of hepatotoxicity was done by chronic oral administration of acetaminophen (750 mg/kg bwt) for 4 weeks...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28565773/pien-tze-huang-gan-bao-ameliorates-carbon-tetrachloride-induced-hepatic-injury-oxidative-stress-and-inflammation-in-rats
#13
Jinyan Zhao, Haixia Hu, Yun Wan, Yuchen Zhang, Liangpu Zheng, Zhenfeng Hong
Liver damage results from a variety of insults, including hepatitis and chemical toxicity from alcohol, drugs and other toxins. The present study evaluated the hepatoprotective effects and potential mechanisms of action of the Traditional Chinese Medicine Pien Tze Huang Gan Bao (GB) in a rat model of carbon tetrachloride (CCl4)-induced liver injury. Sixty male Sprague-Dawley rats were randomly divided into six different groups: i) Control, ii) CCl4 injury model and groups treated with iii) silymarin as a positive drug control, iv) 150 mg/kg GB, v) 300 mg/kg GB and vi) 600 mg/kg GB...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28565752/hepatoprotective-activity-of-chrysin-is-mediated-through-tnf-%C3%AE-in-chemically-induced-acute-liver-damage-an-in-vivo-study-and-molecular-modeling
#14
Anca Hermenean, Teodora Mariasiu, Inmaculada Navarro-González, Josefina Vegara-Meseguer, Eftimie Miuțescu, Sandipan Chakraborty, Horacio Pérez-Sánchez
Chrysin (5,7-dihydroxyflavone) is a naturally occurring flavonoid present at high levels in honey, propolis and numerous plant extracts. Chrysin is known to have hepatoprotective activity, however, the mechanisms by which it exerts this effect remain unclear. In the present study, the effects of chrysin in carbon tetrachloride (CCl4)-induced acute liver damage were investigated and the results used to infer a possible mechanism behind chrysin's hepatoprotective activity. Prior to an intraperitoneal injection of CCl4 (1 ml/kg) to induce acute liver damage, chrysin (50 mg/kg) was administered orally to mice for 7 days...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28562008/inhibition-of-a%C3%AE-amyloid-growth-and-toxicity-by-silybins-the-crucial-role-of-stereochemistry
#15
Michele Francesco Maria Sciacca, Valeria Romanucci, Armando Zarrelli, Irene Monaco, Fabio Lolicato, Natalia Spinella, Clelia Galati, Giuseppe Grasso, Luisa D'Urso, Margherita Romeo, Luisa Diomede, Mario Salmona, Corrado Bongiorno, Giovanni Di Fabio, Carmelo La Rosa, Danilo Milardi
The self-assembling of the amyloid β (Aβ) peptide into neurotoxic aggregates is considered a central event in the pathogenesis of Alzheimer's Disease (AD). Based on the "amyloid hypothesis" much efforts have been devoted in designing molecules able to halt disease progression by inhibiting Aβ self-assembly. Here, we combine biophysical (ThT assays, TEM and AFM imaging), biochemical (WB and ESI-MS) and computational (all-atom Molecular Dynamics) techniques to investigate the capacity of four optically pure components of the natural product Silymarin (Silybin A, Silybin B, 2,3-Dehydrosilybin A, 2,3-Dehydrosilybin B), to inhibit Aβ aggregation...
May 31, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28552108/pistacia-chinensis-strong-antioxidant-and-potent-testicular-toxicity-amelioration-agent
#16
Farah Noureen, Muhammad Rashid Khan, Naseer Ali Shah, Rahmat Ali Khan, Kiran Naz, Saadia Sattar
OBJECTIVES: To evaluate in vitro and in vivo antioxidant potency of Pistacia chinensis (P. chinensis) bark and leaves extracts along with its protective role against CCl4 induced toxicity in testis of the rat. METHODS: Various in vitro models such as DPPH, ABTS, hydrogen peroxide, superoxide, hydroxyl and nitric oxide scavenging activities, anti-lipid peroxidation activity, phospho-molybdenum activity, β carotene bleaching assay was used for analysis of antioxidant potential...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28552106/the-protection-of-thymus-vulgaris-leaves-alcoholic-extract-against-hepatotoxicity-of-alcohol-in-rats
#17
Samah A El-Newary, Nermeen M Shaffie, E A Omer
OBJECTIVE: To investigate the protective effect of Thymus vulgaris (T. vulgaris) leaves 70% alcoholic extract against alcohol-mediate hepatotoxicity rats. METHODS: The protective effect of T. vulgaris extract was investigated at dose of 500 mg/kg/day (as 0.1 of LD50) orally against alcohol-mediate hepatotoxicity using adult male Wister albino rats during 21 days. Protective effect of T. vulgaris extract was evaluated comparing with silymarin standard drug at recommended dose (25 mg/kg/day) orally for 21 days...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28542928/crosstalk-between-e2f1-and-p53-transcription-factors-in-doxorubicin-induced-dna-damage-evidence-for-preventive-protective-effects-of-silymarin
#18
Seyedeh-Khadijeh Shafiei-Roudbari, Hassan Malekinejad, Hamed Janbaz-Aciabar, Mazdak Razi
OBJECTIVES: To study the effects of silymarin in various forms of applications on the molecular mechanism(s) of doxorubicin-induced testicular toxicity in male rats. METHODS: Following DOX administration with or without SMN in male rats, sperm quality assays were conducted. Moreover, total antioxidant capacity and nitric oxide content of testis were determined. Expression profile of p53 and E2F1 was analysed by PCR technique. Ultimately, the rate of DNA fragmentation in the testes was quantitatively measured...
May 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28535741/effects-of-n-acetyl-cysteine-on-oxidative-stress-and-tnf-%C3%AE-gene-expression-in-diclofenac-induced-hepatotoxicity-in-rats
#19
Ali Nouri, Esfandiar Heidarian, Morteza Nikoukar
The consumption of non-steroidal anti-inflammatory drug, such as diclofenac, can lead to hepatotoxicity. In the present study, protective effect of N-acetyl cysteine (NAC) on diclofenac-induced hepatotoxicity was investigated. Thirty-two male rats were divided into four groups. Group 1 (control group) was treated with normal saline (1 ml/kg, i.p.) for 4 d. Group 2 (test without treatment) received diclofenac only (50 mg/kg, i.p.) for 4 d. Groups 3 and 4 received diclofenac (50 mg/kg, i.p.) plus NAC (150 mg/kg, p...
June 8, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28522909/in-vitro-and-in-vivo-antioxidative-and-hepatoprotective-activity-of-aqueous-extract-of-cortex-dictamni
#20
Lin Li, Yun-Feng Zhou, Yan-Lin Li, Li-Li Wang, Hiderori Arai, Yang Xu
AIM: To investigate the antioxidant and hepatoprotective effects of Cortex Dictamni aqueous extract (CDAE) in carbon tetrachloride (CCl4)-induced liver damage in rats. METHODS: The in vitro antioxidant effect of CDAE was investigated using α,α-diphenyl-β-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), β-carotene bleaching, reducing power, and thiobarbituric acid reactive substance assays. A linoleic acid system, including ferric thiocyanate (FTC) and thiobarbituric acid (TBA) assays, was used to evaluate the inhibition of lipid peroxidation...
April 28, 2017: World Journal of Gastroenterology: WJG
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