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https://www.readbyqxmd.com/read/28340483/improving-the-water-solubility-and-antimicrobial-activity-of-silymarin-by-nanoencapsulation
#1
Ji-Soo Lee, Da Young Hong, Eun Suh Kim, Hyeon Gyu Lee
The aims of this study were to improve the water solubility and antimicrobial activity of milk thistle silymarin by nanoencapsulation and to assess the functions of silymarin nanoparticle-containing film as an antimicrobial food-packaging agent. Silymarin nanoparticles were prepared using water-soluble chitosan (WCS) and poly-γ-glutamic acid (γ-PGA). As the WCS and silymarin concentrations increased, particle size and polydispersity index (PDI) significantly increased. Nanoencapsulation significantly improved the water solubility of silymarin 7...
March 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28338269/silymarin-for-the-treatment-of-obsessive-compulsive-disorders-in-dermatology
#2
Katlein França, Torello Lotti
No abstract text is available yet for this article.
March 24, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28330141/evaluation-of-biochemical-markers-during-somatic-embryogenesis-in-silybum-marianum-l
#3
Bilal Haider Abbasi, Huma Ali, Buhara Yücesan, Sabahat Saeed, Khalid Rehman, Mubarak Ali Khan
In present report effects of explants type, basal media and plant growth regulators (PGRs) were tested for induction of indirect somatic embryogenesis in medicinally important plant Silybum marianum L. Leaf, petiole and root explants were exploited in vitro on B5 (Gamborg), SH (Schenk and Hildebrandt) and MS (Murashige and Skoog) media for induction of embryogenic callus followed by somatic embryogenesis. Highest callus induction frequency (76 ± 4.8 %) was recorded when petiole explants of in vitro derived plantlets were cultured on B5 medium supplemented with 1...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28322066/hepatoprotective-effect-against-ccl4-induced-acute-liver-damage-in-mice-and-high-performance-liquid-chromatography-mass-spectrometric-method-for-analysis-of-the-constituents-of-extract-of-rubus-crataegifolius
#4
Yongjiao Sun, Lingyun Jia, Zhanbo Huang, Jing Wang, Jincai Lu, Jing Li
This study is an attempt to evaluate the hepatoprotective activity of Rubus Crataegifolius against carbon tetrachloride-induced liver injury in mice. 70% ethanolic, ethyl acetate and n-BuOH extract of R. crataegifolius were administered daily for 14 days in experimental animals before they were treated with CCl4. The hepatoprotective activity of the extracts in this study was compared with the reference drug silymarin. A high-performance liquid chromatography mass spectrometric (HPLC-EIS-MS/MS) method was developed for the determination of the constituents of the extracts...
March 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28320105/anti-fibrotic-potential-of-human-umbilical-cord-mononuclear-cells-and-mouse-bone-marrow-cells-in-ccl4-induced-liver-fibrosis-in-mice
#5
Nageh Ahmed Elmahdy, Samia Salem Sokar, Mohamed Labib Salem, Naglaa Ibrahim Sarhan, Sherin Hamed Abou-Elela
Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic stellate cells (HSC). The treatment of choice is Liver transplantation; however, it has many problems such as surgery-related complications, immunological rejection and high costs associated with the procedure. Stem cell-based therapy would be a potential alternative, so the aim of this study is to investigate the therapeutic potential of human umbilical cord mononuclear cells (MNC) and mouse bone marrow cells (BMC) against carbon tetrachloride (CCl4) induced liver fibrosis in mice and compare it with that of silymarin...
March 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28320086/antifibrotic-effect-of-diethylcarbamazine-combined-with-hesperidin-against-ethanol-induced-liver-fibrosis-in-rats
#6
Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Dina Zakaria Mohamed
Chronic alcohol consumption leads to extracellular matrix hyperplasia and liver fibrosis with a great role of hepatic stellate cell (HSC) activation in this process. The present study was designed to investigate the possible protective effects of diethylcarbamazine (DEC) (50mg/kg, acting as an anti-inflammatory drug, interferes with the arachidonic acid metabolism) when administrated in combination with hesperidin (HDN) (200mg/kg, a flavanone glycoside with potent antioxidant and anti-inflammatory activities) against alcoholic liver fibrosis in wistar rats compared to silymarin (Sil) (100mg/kg)...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28281782/effects-of-lactulose-and-silymarin-on-liver-enzymes-in-cirrhotic-rats
#7
Mozhgan Ghobadi Pour, Naser Mirazi, Hojjatollah Alaei, Shirin Moradkhani, Ziba Rajaei, Alireza Monsef Esfahani
Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group...
March 10, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28265544/hepatoprotective-activity-of-the-extract-of-homalium-letestui-stem-against-paracetamol-induced-liver-injury
#8
Jude Efiom Okokon, Joseph Oyepata Simeon, Emem Ekpo Umoh
OBJECTIVE: Homalium letestui Pellegr (Flacourtiaceae) has been traditionally used by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases and Yorubas of western Nigeria as an antidote. This study evaluates the hepatoprotective properties of the ethanol extract of the plant stem. MATERIALS AND METHODS: The hepatoprotective effect of the extract of the stem of the plant (200-600 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver...
January 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28259154/hepatoprotective-effect-of-coreopsis-tinctoria-flowers-against-carbon-tetrachloride-induced-liver-damage-in-mice
#9
Jen-Chieh Tsai, Chuan-Sung Chiu, Yun-Chieh Chen, Meng-Shiou Lee, Xiu-Ying Hao, Ming-Tsuen Hsieh, Chun-Pin Kao, Wen-Huang Peng
BACKGROUND: Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role of the plant is not scientifically explored till now. This study was designed to investigate the hepatoprotective potentials of the ethanol extract from C. tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl4)-induced acute liver injury. METHODS: CTEtOH (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) were administered to the experimental mice for 7 days followed by 0...
March 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28254270/silymarin-attenuates-aspartame-induced-variation-in-mouse-behaviour-cerebrocortical-morphology-and-oxidative-stress-markers
#10
Yetunde Onaolapo Adejoke, Zayid Abdusalam Saratu, James Onaolapo Olakunle
OBJECTIVE: We assessed the impacts of silymarin co-administration on aspartame-induced changes in novelty-induced behaviours, memory, anxiety-related behaviours, cerebral antioxidant status and histomorphology in mice. METHOD: Six groups of mice were administered vehicle (distilled water), silymarin (25mg/kg), aspartame (at 160 or 320mg/kg), and silymarin (25mg/kg) co-administered with aspartame at 160 or 320mg/kg daily for 21days, via an oral cannula. Behaviours were assessed after the first and last dose of treatment...
February 15, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28250272/the-binding-of-silibinin-the-main-constituent-of-silymarin-to-site-i-on-human-serum-albumin
#11
Keishi Yamasaki, Hiroki Sato, Saori Minagoshi, Karin Kyubun, Makoto Anraku, Shigeyuki Miyamura, Hiroshi Watanabe, Kazuaki Taguchi, Hakaru Seo, Toru Maruyama, Masaki Otagiri
Silibinin is the main constituent of silymarin, an extract from the seeds of milk thistle (Silybum marianum). Because silibinin has many pharmacological activities, extending its clinical use in the treatment of a wider variety of diseases would be desirable. In this study, we report on the binding of silibinin to plasma proteins, an issue that has not previously been extensively studied. The findings indicated that silibinin mainly binds to human serum albumin (HSA). Mutual displacement experiments using ligands that primarily bind to sites I and II clearly revealed that silibinin binds tightly and selectively to site I (subsites Ia and/or Ic) of HSA, which is located in subdomain IIA...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28246450/protective-effect-of-rutin-in-comparison-to-silymarin-against-induced-hepatotoxicity-in-rats
#12
M Kasi Reddy, A Gopala Reddy, B Kala Kumar, D Madhuri, G Boobalan, M Anudeep Reddy
AIM: The aim of this study is to evaluate the hepatoprotective effect of rutin (RTN) in comparison to silymarin (SLM) against acetaminophen (APAP)-induced hepatotoxicity in rats. MATERIALS AND METHODS: Male Wistar albino rats (n=24) of 3 months age were equally divided into four groups. Group 1 served as normal control. Hepatotoxicity was induced in the remaining three groups with administration of 500 mg/kg po APAP from day 1-3. Groups 2, 3, and 4 were subsequently administered orally with distilled water, 25 mg/kg of SLM, and 20 mg/kg of RTN, respectively, for 11 days...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28236612/determining-the-effects-of-geraniol-on-liver-regeneration-via-the-nuclear-factor-kb-pathway-after-partial-hepatectomy
#13
Emre Ceyhan, Mediha Canbek
Context • Nuclear factor kB (NF-κB) is a dimeric transcription factor that is involved in the regulation of regenerative and apoptosic genes and plays a key role in liver regeneration after a partial hepatectomy (PH). Complementary medicine is used to treat various diseases and can be obtained from a large number of plants that are found in nature. One such plant is geraniol, and no studies have yet occurred assessing its in vivo effects on liver regeneration. Objective • The current study intended to assess the effects of geraniol on liver regeneration after a 70% PH in rats...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236505/protective-effects-of-silymarin-and-curcumin-on-cyclophosphamide-induced-cardiotoxicity
#14
H Avci, E T Epikmen, E Ipek, R Tunca, S S Birincioglu, H Akşit, S Sekkin, A N Akkoç, M Boyacioglu
INTRODUCTION: Cyclophosphamide (CP) is a potent anticancer agent; its clinical use is limited due to its marked cardiotoxicity. AIM: The present study was aimed at evaluating the cardioprotective effects of silymarin (SLY) and curcumin (CUR), which have strong antioxidant properties, against the toxic effects of high-dose CP on the heart of rats. MATERIALS AND METHODS: A total of 36 adult Wistar albino female rats were randomly divided into six groups...
February 21, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28229939/chenopodium-bonus-henricus-l-a-source-of-hepatoprotective-flavonoids
#15
Zlatina Kokanova-Nedialkova, Paraskev Nedialkov, Magdalena Kondeva-Burdina, Rumyana Simeonova, Virginia Tzankova, Denitsa Aluani
Three new flavonoid glycosides (7-9) named patuletin-3-O-(5″'-О-Е-feruloyl)-β-d-apiofuranosyl(1→2)[β-d-glucopyranosyl (1→6)]-β-d-glucopyranoside (7), spinacetin-3-O-(5″'-О-Е-feruloyl)-β-d-apiofuranosyl (1→2)[β-d-glucopyranosyl(1→6)]-β-d-glucopyranoside (8) and 6-methoxykaempferol-3-O-(5″'-О-Е-feruloyl)-β-d-apiofuranosyl(1→2)[β-d-glucopyranosyl (1→6)]-β-d-glucopyranoside (9) together with six known flavonoid glycosides of patuletin, spinacetin and 6-methoxykaempferol (1-6) were isolated from the aerial parts of C...
February 14, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28223871/new-acyclic-secondary-metabolites-from-the-biologically-active-fraction-of-albizia-lebbeck-flowers
#16
Shaza M Al-Massarani, Ali A El Gamal, Mohamed F Abd El Halim, Mansour S Al-Said, Maged S Abdel-Kader, Omer A Basudan, Saleh I Alqasoumi
The total extract of Albizia lebbeck flowers was examined in vivo for its possible hepatoprotective activity in comparison with the standard drug silymarin at two doses. The higher dose expressed promising activity especially in reducing the levels of AST, ALT and bilirubin. Fractionation via liquid-liquid partition and reexamination of the fractions revealed that the n-butanol fraction was the best in improving liver biochemical parameters followed by the n-hexane fraction. However, serum lipid parameters were best improved with CHCl3 fraction...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28222401/combination-of-sitagliptin-and-silymarin-ameliorates-liver-fibrosis-induced-by-carbon-tetrachloride-in-rats
#17
Samia Salem Sokar, Magda El-Sayed El-Sayad, Mai El-Sayed Ghoneim, Abdelhadi Mohamed Shebl
Liver fibrosis is a common pathological condition that occurs in most conditions associated with chronic liver injury. Silymarin is a herbal product widely used for its hepatoprotective effect. Sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP4-I), is clinically used as an oral antidiabetic agent. This study was designed to investigate the effects of Sitagliptin, Silymarin, and their combination on established liver fibrosis in carbon tetrachloride (CCl4) rat model. Male albino rats received intraperitoneal injections of CCl4 three times a week for 7 weeks, as well as daily oral treatments of Sitagliptin (100mg/kg) or Silymarin (100mg/kg) or their combination during the 7 weeks of intoxication...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28216891/effects-of-potassium-sulfate-k2so4-on-the-element-contents-polyphenol-content-antioxidant-and-antimicrobial-activities-of-milk-thistle-silybum-marianum
#18
Gulsum Yaldiz
BACKGROUND: Silybum marianum L. (Milk thistle) is native to the Mediterranean basin and is now widespread throughout the world. It's sprout is used as a herbal medicine for the treatment of liver disease for centuries. The seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. Silymarin acts as a strong anti-hepatotoxic. OBJECTIVES: The objective of this study was to evaluate the influences of potassium sulfate [K2SO4] fertilizer doses on polyphenol content, some nutrient elements, antioxidant and antimicrobial activities of milk thistle at experimental fields of Ordu University in Turkey...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28201965/preparation-and-characterization-of-silymarin-synchronized-and-sustained-release-dropping-pill
#19
Zhi-Hong Liu, Xue-Jing Li, Ai-Wen Huang, Jing Zhang, Hong-Tao Song
PURPOSE: This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics. METHODS: Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning calorimetry, and release were used to evaluate its physicochemical properties. The plasma concentration of silybin in beagle dogs after oral administration of silymarin dropping pills and silymarin capsule was determined by RP-HPLC...
February 13, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28192136/inhibition-of-glycation-and-aldose-reductase-activity-using-dietary-flavonoids-a-lens-organ-culture-studies
#20
Kapil K Patil, Rajesh N Gacche
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflavanone, formononetin, hesperetin, hesperidin, naringenin, naringin, rutin, diadzin, silibinin and silymarin was evaluated as possible inhibitors of sugar induced cataractogenesis using bovine lens organ culture studies. The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition...
May 2017: International Journal of Biological Macromolecules
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