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Silymarin

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https://www.readbyqxmd.com/read/28911647/characterization-and-hepatoprotective-activity-of-anthocyanins-from-purple-sweet-potato-ipomoea-batatas-l-cultivar-eshu-no-8
#1
Lin Wang, Ying Zhao, Qing Zhou, Chun-Li Luo, Ai-Ping Deng, Zi-Cheng Zhang, Jiu-Liang Zhang
The hepatoprotective activity of anthocyanin-rich purple sweet potato extract (APSPE) was demonstrated. Sixty mice were randomly divided into six groups: control group [without carbon tetrachloride (CCl4) or APSPE]; model group (with CCl4 only); positive control group (50 mg/kg body weight silymarin); low-dose group (100 mg/kg body weight APSPE); medium-dose group (200 mg/kg body weight APSPE); and high-dose group (400 mg/kg body weight APSPE). After 10 days intragastric administration of the respective supplements, the mice in all groups except control were injected intraperitoneally with CCl4 (0...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28895929/effects-of-oral-administration-of-silymarin-in-a-juvenile-murine-model-of-non-alcoholic-steatohepatitis
#2
Veronica Marin, Silvia Gazzin, Sabrina E Gambaro, Matteo Dal Ben, Sonia Calligaris, Monica Anese, Alan Raseni, Claudio Avellini, Pablo J Giraudi, Claudio Tiribelli, Natalia Rosso
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only alternative. In this study, we assessed the protective effects of silymarin in a juvenile non-alcoholic steatohepatitis (NASH) model and the in vitro effects on fat-laden human hepatocytes. C57Bl/6 mice were exposed to HFHC diet immediately after weaning. After eight weeks, animals showed histological signs of NASH...
September 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28887915/hepatoprotective-naphthalene-diglucoside-from-neanotis-wightiana-aerial-parts
#3
Niranjan Das, Atanas G Atanasov, Prashanta Kumar Deb, Andrei Mocan, Seyed Mohammad Nabavi, Ranjib Ghosh, Biswanath Dinda
BACKGROUND: Neanotis wightiana (Wall. ex Wight & Arn) W.H. Lewis has been used in traditional medicine in India for the treatment of liver disorders. In fact, this plant is frequently used by the local people of Tripura for the treatment of liver disorder problems. In previous study on this plant we have isolated a hepatoprotective saponin, neanoside A. PURPOSE: Evaluation of in vivo hepatoprotective effects of isolated compounds from N. wightiana aerial parts on serum hepatic-biomarkers in CCl4- induced hepatotoxicity in rats to validate the traditional use of the plant...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28882954/antrodia-cinnamomea-reduces-carbon-tetrachloride-induced-hepatotoxicity-in-male-wister-rats
#4
Yung-Luen Shih, Ming-Fang Wu, Ching-Hsiao Lee, Ming-Yang Yeh, Jason Chou, Jia-You Liu, Hsu-Feng Lu, Yi-Ping Huang, Nien-Chieh Liao, Jing-Gung Chung
BACKGROUND/AIM: Antrodia cinnamomea is found with polysaccharides, lipids, vitamins, fibers and ash (minerals) and is well known in Taiwan as a traditional Chinese medicine. Its biological activities have been reported to have anti-inflammatory, anti-fatigue, anti-tumor and immunomodulatory effects, but its protective effects on liver function are still unclear. MATERIALS AND METHODS: We determined if Antrodia cinnamomea was hepatoprotective against carbon tetrachloride (CCl4) toxicity in Wistar rats...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28869895/the-biochemical-effects-of-nano-tamoxifen-and-some-bioactive-components-in-experimental-breast-cancer
#5
Afaf Ezzat, Abdou Osman Abdelhamid, Mostafa K El Awady, Amal S Abd El Azeem, Dina Mostafa Mohammed
The effect of nano tamoxifen and some bioactive components such as yeast, isoflavone, and silymarin on the level of resistance and prevention of breast cancer progression in experimental animals is the target of this study. Thirty female Sprague-Dawley rats received a single medication dosage of 7,12-dimethylbenz[a]anthracene (DMBA) intragastrically. After fourteen days of DMBA admission, the procedure protocol started out. Finally, all the experimental results evaluated, tabulated and statistically analyzed...
September 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28867857/ethnopharmacological-based-evaluation-of-anogeissus-pendula-edgew-extracts-for-antioxidant-and-hepatoprotective-potential
#6
Deeksha Singh, Uttam Singh Baghel, Manmeet Singh Pannu, Rakesh Yadav
BACKGROUND: Anogeissus pendula has various reported ethnomedicinal uses and is reported to contain phenolic compounds which have antioxidant potential. AIM: The present study was undertaken to evaluate the in vitro antioxidant potential and in vivo hepatoprotective activity along with the oxidative stress parameters of stem bark and leaves of Anogeissus pendula for the first time. SETTINGS AND DESIGN: Albino rats were divided into seven groups of six animals each...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28863306/the-study-of-flavonolignan-association-patterns-in-fruits-of-diverging-silybum-marianum-l-gaertn-chemotypes-provides-new-insights-into-the-silymarin-biosynthetic-pathway
#7
Tommaso Martinelli, Anne Whittaker, Stefano Benedettelli, Andrea Carboni, Jadwiga Andrzejewska
Silymarin is the phytochemical with medicinal properties extracted from Silybum marianum (L.) Gaertn. fruits. Yet, little information is available about silymarin biosynthesis. Moreover, the generally accepted pathway, formulated thus far, is not in agreement with actual experimental measurements on flavonolignan contents. The present work analyses flavonolignan and taxifolin content in 201 S. marianum samples taking into consideration a wide phenotypic variability. Two stable chemotypes were identified: one characterized by both high silychristin and silybin content (chemotype A) and another by a high silydianin content (chemotype B)...
August 29, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28842342/phytochemical-analysis-molecular-docking-and-antiamnesic-effects-of-methanolic-extract-of-silybum-marianum-l-gaertn-seeds-in-scopolamine-induced-memory-impairment-in-mice
#8
Nausheen Nazir, Nasiara Karim, Heba Abdel-Halim, Imran Khan, Syed Fazal Wadood, Muhammad Nisar
ETHNOPHARMACOLOGICAL RELEVANCE: Silybum marianum (L.) Gaertn and its main component silymarin have been extensively studied and have been found effective in various neurological disorders. AIMS OF THE STUDY: The aim of the current study is to identify phytoconstituents in the methanolic extract (Me. Ext) of Silybum marianum (L.) Gaertn seeds and to study in-vivo the anti-amnesic effects along with in vitro antioxidant and acetylcholinesterase (AChE) and buteryl cholinesterase (BChE) inhibition potential...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28810529/silymarin-induces-a-multi-targeted-cell-death-process-in-the-human-colon-cancer-cell-line-ht-29
#9
L Khorsandi, G Saki, N Bavarsad, M Mombeini
This study investigated the Silymarin (SM) effects on growth of HT-29 human colon cancer cell line and its cellular death mechanism. HT-29 cells were treated by 25μM/ml of SM for 48h. HT-29 cells were also pretreated with 10mmol zVAD (apoptosis inhibitor), 10mmol 3-MA (autophagy inhibitor) and 3mmol Nec (necroptosis inhibitor) for evaluation cell death induced by apoptosis, outophagy and necroptosis. MTT and clonogenicity assays revealed that the SM without inhibitors induced a significant decrease in cell viability and proliferation of HT-29 cells (p<0...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28808887/chronic-silymarin-quercetin-and-naringenin-treatments-increase-monoamines-synthesis-and-hippocampal-sirt1-levels-improving-cognition-in-aged-rats
#10
F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Moranta
Polyphenols have beneficial neurological effects delaying cognitive and motor decline in aging due to their antioxidant, antiinflammatory and neuroprotective properties. These effects could be related to SIRT1 activation (implicated in synaptic plasticity, memory and inflammation) and monoaminergic synthesis modulation. In this work, we studied in old male rats, the in vivo effects of long-term administration of different polyphenols (silymarin, quercetin and naringenin; 20 mg/kg/day i.p, 4 weeks) (Sprague-Dawley, 18 months) on cognition and motor coordination...
August 14, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28804034/silymarin-in-nonalcoholic-steatohepatitis-a-new-kid-on-the-block
#11
EDITORIAL
Katharina L Hupa, Elmar Jaeckel, Michael P Manns
No abstract text is available yet for this article.
August 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28797264/flavonolignans-inhibit-the-arachidonic-acid-pathway-in-blood-platelets
#12
Michal Bijak, Joanna Saluk-Bijak
BACKGROUND: Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for blood platelets' activation, which is associated with pro-thrombotic platelet activity and the production of pro-inflammatory mediators. Inhibition of COX activity is one of the major means of anti-platelet pharmacotherapy preventing arterial thrombosis and reducing the incidence of cardiovascular events. Recent studies have presented that a silymarin (standardized extract of Milk thistle (Silybum marianum)) can inhibit the COX pathway...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28795371/hepatoprotective-and-cytotoxic-activities-of-anvillea-garcinii-and-isolation-of-four-new-secondary-metabolites
#13
Shagufta Perveen, Areej Mohammad Al-Taweel, Hasan Soliman Yusufoglu, Ghada Ahmed Fawzy, Ahmed Foudah, Maged Saad Abdel-Kader
Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A-D, along with seven known compounds, were isolated from the leaves of A. garcinii. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and n-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model...
August 9, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#14
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28756924/antioxidant-and-hepatoprotective-potentials-of-novel-endophytic-fungus-achaetomium-sp-from-euphorbia-hirta
#15
K P G Uma Anitha, S Mythili
OBJECTIVE: To isolate, identify and evaluate the antioxidant, antimicrobial, hepatoprotective potentials, total phenolic content, flavonoid content, tannin content of ethyl acetate extract of endophytic fungus Achaetomium sp., isolated from Euphorbia hirta. METHODS: Hepatoprotectivity of ethyl acetate extract of Achaetomium sp., was evaluated by CCl4 induced toxicity in HepG2 cells and subsequently analysed for cell viability using MTT assay. It also demonstrates antioxidant and antimicrobial potentials by DPPH radical scavenging assay and well diffusion assay respectively...
June 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28756693/improved-hepatoprotective-activity-of-silymarin-via-encapsulation-in-the-novel-vesicular-nanosystem-bilosomes
#16
Amira Mohamed Mohsen, Marwa Hasanein Asfour, Abeer A A Salama
The main objective of the present work was to formulate, characterize and evaluate silymarin (SM) loaded bilosomes, compared to conventional liposomes, aiming at increasing the hepatoprotective activity of the drug. SM loaded bilosomes were prepared by thin film hydration technique employing Soybean Phosphatidyl Choline (SPC) and different bile salts. After being subjected to different methods of characterization, SM loaded bilosomes were investigated for their hepatoprotective activity, in CCl4 hepatointoxicated rat model...
July 31, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28747959/effect-of-prophylactic-use-of-silymarin-on-anti-tuberculosis-drugs-induced-hepatotoxicity
#17
Eunyoung Heo, Deog Kyeom Kim, So Hee Oh, Jung-Kyu Lee, Ju-Hee Park, Hee Soon Chung
BACKGROUND: The first line of anti-tuberculosis (TB) drugs are the most effective standard of drugs for TB. However, the use of these drugs is associated with hepatotoxicity. Silymarin has protective effects against hepatotoxicity of anti-TB drugs in animal models. This study aims to investigate the protective effect of silymarin on hepatotoxicity caused by anti-TB drugs. METHODS: This is a prospective, randomized, double-blind and placebo-controlled study. Patients were eligible if they were 20 years of age or order and started the first-line anti-tuberculosis drugs...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28736996/phytochemical-investigation-antitumor-activity-and-hepatoprotective-effects-of-acrocarpus-fraxinifolius-leaf-extract
#18
Heba A S El-Nashar, Omayma A Eldahshan, Omama E Elshawi, Abdel Nasser B Singab
Preclinical Research Nine known phenolic compounds were isolated from an aqueous methanolic extract of Acrocarpus fraxinifolius Weight and Arn leaves (AFL) family Fabaceae. This extract of AFL contained approximately 169 mg gallic acid/g as assessed by HPLC. The AFL extract had marginal antitumor activity (IC50  > 200 µL/mL) but showed a concentration-dependent hepatoprotective effect against CCl4 -induced hepatotoxicity in vitro. Cell viability was increased, ALT and AST activity declined and reduced GSH concentration and SOD activity were restored as compared with silymarin...
July 24, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#19
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28713991/pien-tze-huang-gan-bao-attenuates-carbon-tetrachloride%C3%A2-induced-hepatocyte-apoptosis-in-rats-associated-with-suppression-of-p53-activation-and-oxidative-stress
#20
Jinyan Zhao, Yuchen Zhang, Yun Wan, Haixia Hu, Zhenfeng Hong
Pien Tze Huang Gan Bao (PZH‑GB), a traditional Chinese medicine, has been used for thousands of years as a protective remedy effective against liver injury induced by excessive alcohol and smoking. The present study aimed to evaluate the protective effects and potential mechanisms of PZH‑GB against carbon tetrachloride (CCl4)‑induced hepatic injury. Rats were pre‑treated with silymarin (50 mg/kg) or different doses of PZH‑GB (150, 300 or 600 mg/kg) orally administered for 7 days. At the end of treatment, the rats were intraperitoneally injected with CCl4, or control rats received a corn oil injection...
September 2017: Molecular Medicine Reports
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