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Lifeng Qin, Jinmei Qin, Xiumei Zhen, Qian Yang, Liyi Huang
The C-X-C motif chemokine 12/C-X-C chemokine receptor type 4 (CXCL12/ CXCR4) biological axis plays an important role in the pathogenesis of liver fibrosis. Curcumin is known to have an anti-fibrosis effect, but the specific mechanism needs to be elucidated. There is currently no evidence illustrating a connection between curcumin and the CXCL12/CXCR4 axis in liver fibrosis. Here, we investigated the contribution of curcumin on CXCL12/ CXCR4 biological axis in liver fibrosis. Our results showed that curcumin remarkably improved hepatic function and liver fibrosis, and the effects are similar as silymarin...
March 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Alamgeer, Zain Nasir, Muhammad Naeem Qaisar, Ambreen Malik Uttra, Haseeb Ahsan, Kifayat Ullah Khan, Ikram Ullah Khan, Muhamamd Saleem, Khadijai, Hira Asif, Amber Sharif, Waqas Younis, Huma Naz
Hepatic diseases are becoming common day by day and pose serious health threats to the life of humans. In order to treat these diseases, the attention of man is diverting towards herbal drugs, which are much safer and cost effective than synthetic drugs. The aim of present study was to investigate hepatoprotective activity of methanolic extract of Melilomus officinalis against paracetamol and carbon tetrachloride induced hepatic damage. Melilotus officinalis at selected oral doses of 50 mg/kg and 100 mg/kg showed significant hepatoprotective effects by decreasing the levels of serum marker enzymes such as total bilirubin, SGOT, SGPT, ALP, albumin and total protein, when compared with standard drug (silymarin) and negative control...
May 2017: Acta Poloniae Pharmaceutica
Rahimeh Rahimi, Jamshid Karimi, Iraj Khodadadi, Heidar Tayebinia, Nejat Kheiripour, Mohammad Hashemnia, Fatemeh Goli
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular disease (CVD). Urotensin II ((U-II)) and its receptor (UTR) are involved in the progression of CVD through enhancement in the production of reactive oxygen species (ROS). Since silymarin (SMN) is a natural agent with anti-diabetic effects, this study aimed to investigate the antioxidant potency of SMN on the expression of (U-II)/UTR system and oxidative stress status in the heart of type 2 diabetic rats. Thirty-six male Wistar rats were randomly divided into six groups (n = 6)...
February 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Salma M Eraky, Mohamed El-Mesery, Amro El-Karef, Laila A Eissa, Amal M El-Gayar
AIMS: Lysophosphatidic acid is a lipid mediator that is supposed to be implicated in hepatic fibrosis. Silymarin and caffeine are natural compounds known for their anti-inflammatory and antioxidant effects. Our study aimed to explore the effect of silymarin, caffeine, and their combination on lysophosphatidic acid receptor 1 (LPAR1) pathway in thioacetamide (TAA)-induced hepatic fibrosis. MAIN METHODS: Hepatic fibrosis was induced in male Sprague-Dawley rats by intraperitoneal injection of 200 mg/kg of TAA twice a week for 8 weeks...
February 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nejat Kheiripour, Jamshid Karimi, Iraj Khodadadi, Heidar Tavilani, Mohammad Taghi Goodarzi, Mohammad Hashemnia
BACKGROUND: In this study, we have investigated whether silymarin intake influences lipid and glycogen content in conjunction with sirtuin1 (SIRT1) and sterol regulatory element-binding protein 1c (SREBP-1c) expressions in liver of type 2 diabetic rat. METHODS: Thirty-six male Wistar rats were randomly divided into six groups: control groups (C) and diabetic groups (D); the control groups received 60 or 120 mg/kg silymarin (C+S60 or C+S120), and the diabetic groups received 60 or 120 mg/kg silymarin (D+S60 or D+S120) daily for 8 weeks...
February 24, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Scholastica Onyebuchi Anadozie, Jacob Ayodele Akinyemi, Shadrach Agunbiade, Basiru Olaitan Ajiboye, Olusola Bolaji Adewale
Bryophyllum pinnatum (B. pinnatum) (Lam.) Oken is used in tropical Africa for the treatment of several diseases such as kidney and urinary disorders. This study was aimed to evaluate the effect of B. pinnatum on arginase II activity and its prevention against renal oxidative damage occasioned by CCl4 in rats. Rats were randomly divided into six groups; group I served as the control, group II served as carbon tetrachloride (CCl4 ) intoxicated group, group III-V animals were pre-treated with silymarin (25 mg/kg body weight), 25 mg/kg body weight aqueous extracts of Bryophyllum pinnatum (AEBP) and 50 mg/kg body weight AEBP, respectively, for 14 days, followed by a single injection of CCl4...
February 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Fatema R Saber, Ghada A Abdelbary, Maha M Salama, Dalia O Saleh, Magda M Fathy, Fathy M Soliman
Liver diseases are major health problem in Egypt influencing lifestyle and economy. The demand for nutraceutical hepatoprotective agents is crucial to ameliorate the side effects of synthetic drugs. The present study aims to evaluate antioxidant and hepatoprotective activities of extracts of Psidium guajava L. and Psidium cattleianum Sabine leaves and their nano-formulated liposomes against paracetamol-induced liver damage in rats. Secondary metabolites profile of P. guajava and P. cattleianum leaves was investigated using UPLC-PDA-ESI-qTOF-MSn...
March 2018: Food Research International
Sameh Saber, Amr A A Mahmoud, Noha Said Helal, Eman El-Ahwany, Rasha Abdelghany
Therapeutic interventions for liver fibrosis are still limited due to the complicated molecular pathogenesis. Renin-angiotensin system (RAS) seems to contribute to the development of hepatic fibrosis. Therefore, we aimed to examine the effect of RAS inhibition on CCl4-induced liver fibrosis. Mice were treated with silymarin (30 mg kg-1), perindopril (1 mg kg-1), fosinopril (2 mg kg-1), or losartan (10 mg kg-1). The administration RAS inhibitors improved liver histology and decreased protein expression of alpha smooth muscle actin (α-SMA) and hepatic content of hydroxyproline...
February 9, 2018: Canadian Journal of Physiology and Pharmacology
Ali Sharifi-Rigi, Esfandiar Heidarian, Sayed Asadollah Amini
CONTEXT: Toxicity with paraquat can lead to serious damages to the liver. OBJECTIVE: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage. MATERIAL AND METHODS: Rats were divided into six groups. Group 1, the control group; group 2, rats that received paraquat only; group 3, rats that received paraquat plus silymarin; and groups 4, 5, and 6 were treated with paraquat and O. vulgare leaf extract...
February 9, 2018: Archives of Physiology and Biochemistry
Marta García-Ramírez, Mireia Turch, Olga Simó-Servat, Cristina Hernández, Rafael Simó
INTRODUCTION: Vascular endothelial growth factor (VEGF) plays an essential role in development of diabetic macular edema (DME). While there is evidence suggesting that silymarin, a flavonoid extracted from Silybum marianum, could be useful for prevention and treatment of diabetic nephropathy, no studies have been conducted in diabetic retinopathy (DR). The aim of this study was to assess the effect of silymarin on disruption of inner blood retinal barrier (BRB), the primary cause of DME...
February 5, 2018: Endocrinología, Diabetes y Nutrición
Nehal Aly Afifi, Marwa Ibrahim, Mona Galal
Despite all the studies performed up to now, therapy choices for liver injuries are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. The Quercetin (QR) and ellagic acid (EA) had a potent antioxidant and anti-inflammatory activities. The current study aimed at evaluating the potential hepatoprotective influence of QR and EA against thioacetamide (TAA)-induced liver toxicity in rats and the underlying mechanism using silymarin as a reference drug...
February 7, 2018: Canadian Journal of Physiology and Pharmacology
Nada M Mostafa, Eman A Abd El-Ghffar, Hoda G Hegazy, Omayma A Eldahshan
Flavonoids are agents with strong antioxidant properties and ameliorate many diseases associated with oxidative stress. Leaves of Casimiroa sapota (CS) was investigated for components and anti-inflammatory activities against lead acetate (PbAc) induced hepatotoxicity in rats. Two groups of male albino rats were administrated orally CS (100 and 200 mg/kg b.w/day) for 28 days; other group was injected with sub-acute dose (100 mg/kg b.w/day) of PbAc. Three protective groups were injected with PbAc (100 mg/kg b...
February 6, 2018: Chemistry & Biodiversity
Doaa I Mohamed, Enas S Nabih, Dalia A A El-Waseef, Omnyah A El-Kharashi, Abeer A Abd El Samad
Impaired glucose homoeostasis due to insulin resistance and decrease sensitivity of pancreatic β-cells is a feature of liver disease and results into hepatogenous diabetes. Decrease expression of CD39 was linked to inflammation and occurrence of diabetes. Therefore, we performed this study to explore the protective effect of pentoxifylline (PTX) and silymarin administration on the β-cells of the pancreas in a rat model of thioacetamide induced liver cirrhosis. Biochemical, histological and immunohistochemistry studies of the liver and pancreas were performed and provided an evidence on the protective effect of PTX to pancreatic β-cells compared to silymarin...
February 2, 2018: Gene
Sumanta Mondal, Debjit Ghosh, Seru Ganapaty, Surya Vamsi Gokul Chekuboyina, Manisha Samal
Macrothelypteris torresiana is a fern species belonging to family Thelypteridaceae. The present study was conducted to evaluate hepatoprotective potential of ethanol extract from M. torresiana aerial parts (EEMTAP) and detect the polyphenolic compounds present in the extract using high performance thin layer chromatography (HPTLC). Hepatoprotective potential of EEMTAP were tested at doses of 300 and 600 mg/kg, per os (p.o.), on Wistar albino rats. The extract and silymarin treated animal groups showed significant decrease in activities of different biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), alkaline phosphatase (ALP), which were elevated by carbon tetrachloride (CCl4) intoxication...
June 2017: Journal of Pharmaceutical Analysis
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi
BACKGROUND: Steatosis is a chronic liver disease that depends on the accumulation of intracellular fatty acids. Currently, no drug treatment has been licensed for steatosis; thus, only nutritional guidelines are indicated to reduce its progression. The aim of this study is to combine different nutraceutical compounds in order to evaluate their synergistic effects on a steatosis in vitro model compared to their separate use. In particular, three different formulations based on silymarin, curcumin, vitamin E, docosahexaenoic acid (DHA), choline, and phosphatidylcholine were assayed...
February 5, 2018: Lipids in Health and Disease
Hong Cui, Tie-Ling Li, Hai-Feng Guo, Jia-Liang Wang, Ping Xue, Ying Zhang, Jing-Hui Fan, Zhi-Ping Li, Yue-Juan Gao
A novel module-search algorithm method was used to screen for potential signatures and investigate the molecular mechanisms of inhibiting hepatocellular carcinoma (HCC) growth following treatment with silymarin (SM). The modules algorithm was used to identify the modules via three major steps: i) Seed gene selection; ii) module search by seed expansion and entropy minimization; and iii) module refinement. The statistical significance of modules was computed to select the differential modules (DMs), followed by the identification of core modules using the attract method...
January 2018: Oncology Letters
Ila Shukla, Lubna Azmi, Shyam Sundar Gupta, Dalip Kumar Upreti, Chandana Venkateswara Rao
BACKGROUND: Reindeer lichen, Lichen rangiferinus syn. or Cladonia rangiferina (L.) F. H. Wigg. (Cladoniaceae) has been traditionally reported as a remedy to treat fever, colds, arthritis as well as convulsions, liver infections, coughs, constipation, and tuberculosis. The current study is aimed at rectification of alcohol induced liver damage by the use of L. rangiferinus extract. OBJECTIVES: The aim of the study was to compare some biochemical markers for liver injury and hematological indices in normal untreated rats and treated rats...
January 29, 2018: Journal of Ayurveda and Integrative Medicine
Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan
BACKGROUND: Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmacological properties. The current investigation aimed to assess the protective potential of A. hydaspica polyphenol rich ethyl acetate extract (AHE) against cisplatin (CP) induced pulmonary toxicity. METHODS: Rats were divided into six groups...
February 2, 2018: BMC Complementary and Alternative Medicine
Ana Ferreira, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão, Gilberto Alves
The pharmacoresistance to antiepileptic drugs (AEDs) remains a major unsolved therapeutic need. The overexpression of multidrug transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggested as a key mechanism underlying the refractory epilepsy. Thus, efforts have been made to search for therapeutically useful P-gp inhibitors. Herein, the strategy of flavonoid/AED combined therapy was exploited as a possible approach to overcome the P-gp-mediated pharmacoresistance...
January 2018: Food Research International
Yung-Jia Chiu, Shen-Chieh Chou, Chuan-Sung Chiu, Chun-Pin Kao, Kun-Chang Wu, Chao-Jung Chen, Jen-Chieh Tsai, Wen-Huang Peng
Polygonum orientale L. (Polygonaceae) fruits have various medicinal uses, but their hepatoprotective effects have not yet been studied. This study investigated the hepatoprotective activity of the ethanolic extract of P. orientale (POE) fruits against carbon tetrachloride (CCl4)-induced acute liver injury (ALI). Mice were pretreated with POE (0.1, 0.5, and 1.0 g/kg) or silymarin (0.2 g/kg) for 5 consecutive days and administered a dose of 0.175% CCl4 (ip) on the 5th day to induce ALI. Blood and liver samples were collected to measure antioxidative activity and cytokines...
January 2018: Journal of Food and Drug Analysis
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