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https://www.readbyqxmd.com/read/29156491/long-term-calcineurin-inhibitor-therapy-and-brain-function-in-patients-after-liver-transplantation
#1
Henning Pflugrad, Anna-Kristina Schrader, Anita Blanka Tryc, Xiaoqi Ding, Heinrich Lanfermann, Elmar Jäckel, Harald Schrem, Jan Beneke, Hannelore Barg-Hock, Jürgen Klempnauer, Karin Weissenborn
BACKGROUND AND AIMS: Calcineurin inhibitors (CNI) frequently induce neurological complications early after orthotopic liver transplantation (OLT). We hypothesize that long-term CNI therapy after OLT causes dose-dependent cognitive dysfunction and alteration of brain structure. METHODS: Eighty-five OLT patients (20 with CNI free, 35 with CNI low dose and 30 with standard dose CNI immunosuppression) underwent psychometric testing and cerebral magnetic resonance tomography about 10 years after OLT to assess brain function and structural brain alterations...
November 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29155020/the-uk-dcd-risk-score-a-new-proposal-to-define-futility-in-donation-after-circulatory-death-liver-transplantation
#2
Andrea Schlegel, Marit Kalisvaart, Irene Scalera, Richard W Laing, Hynek Mergental, Darius F Mirza, Thamara Perera, John Isaac, Philipp Dutkowski, Paolo Muiesan
OBJECTIVES: To design a new score on risk assessment in liver transplantation donated after circulatory death (DCD) based on donor and recipient parameters. BACKGROUND: Primary-non-function (PNF) and ischemic cholangiopathy (IC) are the most feared complications following DCD liver transplantation. METHODS: Using the United Kingdom (UK) national DCD database, a risk analysis was performed in adult recipients of DCD liver grafts in UK between 2000 and 2015 (n=1153)...
November 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29152478/changes-in-dietary-patterns-and-body-composition-within-12-months-of-liver-transplantation
#3
Simone M McCoy, Katrina L Campbell, Annie-Claude M Lassemillante, Matthew P Wallen, Jonathan Fawcett, Maree Jarrett, Graeme A Macdonald, Ingrid J Hickman
Background: Cardiometabolic risk factors are increasing in liver transplant recipients (LTR). Influencing dietary factors have not been assessed. The aim of this observational study was to assess changes in weight, metabolic function, dietary intake and eating behaviours in the first year after orthotopic liver transplantation (OLT). Methods: Consecutive recruitment of 17 patients (14 males) awaiting OLT at a single tertiary hospital. Dietary intake, food behaviours and anthropometry were recorded at baseline, and 6 and 12 months post-transplant...
October 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29144772/subchondral-bone-degradation-after-microfracture-for-osteochondral-lesions-of-the-talus-an-mri-analysis
#4
Yoshiharu Shimozono, Max Coale, Youichi Yasui, Amanda O'Halloran, Timothy W Deyer, John G Kennedy
BACKGROUND: Microfracture is the most common cartilage-reparative procedure for the treatment of osteochondral lesions of the talus (OLTs). Damage to the subchondral bone (SCB) during microfracture may irreversibly change the joint-loading support of the ankle, leading to reparative fibrocartilage degradation over time. PURPOSE: To investigate the morphological change in the SCB after microfracture for OLT by developing a novel magnetic resonance imaging (MRI) scoring system specifically for evaluating the SCB...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29136322/heme-oxygenase-1-regulates-sirtuin-1-autophagy-pathway-in-liver-transplantation-from-mouse-to-human
#5
Kojiro Nakamura, Shoichi Kageyama, Shi Yue, Jing Huang, Takehiro Fujii, Bibo Ke, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver transplantation (OLT). Although graft autophagy is essential for resistance against hepatic IRI, its significance in clinical OLT remains unknown. Despite recent data identifying heme oxygenase-1 (HO-1) as a putative autophagy inducer, its role in OLT and interactions with Sirtuin-1 (SIRT1), a key autophagy regulator, have not been studied. We aimed to examine HO-1 mediated autophagy induction in human OLT and in a murine OLT model with extended (20h) cold storage, as well as to analyze the requirement for SIRT1 in autophagy regulation by HO-1...
November 14, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29128026/hepatopulmonary-syndrome-and-portopulmonary-hypertension-implications-for-liver-transplantation
#6
REVIEW
Shaz Iqbal, Kerri Akaya Smith, Vandana Khungar
Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) represent serious pulmonary complications of advanced liver diseases. Orthotopic liver transplantation (OLT) is capable of completely resolving the underlying abnormalities associated with HPS. On the other hand, post-OLT response in patients with PoPH is less predictable, although heavily influenced by pre-OLT mean pulmonary arterial pressure. It remains the case that the opportunity to reverse 2 potentially fatal organ dysfunctions in the liver and the lung make HPS and PoPH more than worthy for further clinical investigations...
December 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29126043/biphasic-bioresorbable-scaffold-trufit-plug-%C3%A2-for-the-treatment-of-osteochondral-lesions-of-talus-6-to-8-year-follow-up
#7
Elvira Di Cave, Pierluigi Versari, Fabio Sciarretta, David Luzon, Lorenzo Marcellini
BACKGROUND: The ideal treatment of osteochondral lesions of the talus (OLT) is debatable. The TruFit plug has been investigated as a potential treatment method for osteochondral defects. This is a biphasic scaffold designed to stimulate cartilage and subchondral bone formation. The purpose of this retrospective study was to investigate the long-term functional and MRI outcomes of the TruFit Plug for the treatment of OLT. METHODS: Twelve consecutive patients treated from March 2007 to April 2009 for OLT were evaluated...
June 3, 2017: Foot
https://www.readbyqxmd.com/read/29108844/liver-transplantation-for-primary-hepatic-malignancies-of-childhood-the-unos-experience
#8
Emma C Hamilton, Julius Balogh, Duc T Nguyen, Edward A Graviss, Andras A Heczey, Mary T Austin
BACKGROUND/PURPOSE: The purpose of this study was to determine factors associated with patient and graft survival following orthotopic liver transplantation (OLT) in children and adolescents with primary hepatic malignancies. METHODS: The United Network for Organ Sharing (UNOS) database was queried for all patients <18years old who received an OLT with a primary malignant liver tumor between 1987 and 2012 (n=544). Five-year patient and graft survival were determined using Kaplan-Meier methodology, and independent predictors of survival were determined using multivariate Cox proportional hazards model...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29097869/delayed-and-short-course-of-rapamycin-prevents-organ-rejection-after-allogeneic-liver-transplantation-in-rats
#9
Salim Hamdani, Allan Thiolat, Sina Naserian, Cynthia Grondin, Stéphane Moutereau, Anne Hulin, Julien Calderaro, Philippe Grimbert, José Laurent Cohen, Daniel Azoulay, Caroline Pilon
AIM: To test whether a delayed and short course of rapamycin would induce immunosuppressive effects following allogeneic orthotopic liver transplantation (OLT) in rats. METHODS: Allogeneic OLTs were performed using Dark Agouti livers transplanted into Lewis recipients, and syngeneic OLTs were performed using the Lewis rat strain. Rapamycin (1 mg/kg per day) was administered by gavage from day 4 to day 11 post-transplantation. Lymphocyte cellular compartments were analyzed by flow cytometry in draining lymph nodes, non-draining lymph nodes and the spleen at days 11 and 42 in rapamycin-treated rats, untreated control rats and syngeneic grafted rats...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29094011/scaffolds-based-therapy-for-osteochondral-lesions-of-the-talus-a-systematic-review
#10
Yoshiharu Shimozono, Youichi Yasui, Andrew W Ross, Wataru Miyamoto, John G Kennedy
AIM: To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus (OLT). METHODS: A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence (LOE) and quality of evidence (QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated...
October 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29063856/does-neoadjuvant-doxorubicin-drug-eluting-bead-transarterial-chemoembolization-improve-survival-in-patients-undergoing-liver-transplant-for-hepatocellular-carcinoma
#11
Dimitri Dorcaratto, Venkatesha Udupa, Niamh M Hogan, David P Brophy, Jeffrey W McCann, Donal Maguire, Justin Geoghegan, Colin P Cantwell, Emir Hoti
PURPOSE: We aimed to compare the overall (OS) and disease-free survival (DFS) of patients undergoing orthotopic liver transplant (OLT) for hepatocellular carcinoma who did and did not have neoadjuvant doxorubicin drug-eluting bead transarterial chemoembolization (DEB-TACE). METHODS: This is a retrospective study of 94 patients with HCC transplanted between 2000 and 2014 in a single tertiary center. Pre- and postoperative features, DFS and OS were compared between patients who received pre-OLT DEB-TACE (n=34, DEB-TACE group) and those who did not (n=60, non-TACE group)...
November 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29055929/endoscopic-therapy-is-effective-for-recurrent-anastomotic-biliary-strictures-after-orthotopic-liver-transplantation
#12
Sun-Chuan Dai, David Goldberg, Amol Agarwal, Gene K Ma, Clinton Yam, Nuzhat A Ahmad, Gregory G Ginsberg, David L Jaffe, Michael L Kochman, Kim M Olthoff, Vinay Chandrasekhara
INTRODUCTION: Orthotopic liver transplantation anastomotic biliary strictures (OLT ABS) are managed with endoscopic biliary stent therapy but the recurrence rate is substantial. Our aims were to retrospectively determine the recurrence rates of OLT ABS after initial successful stent therapy, characterize the management of recurrences and identify associated variables. MATERIALS AND METHODS: Clinical data from 943 patients receiving non-living donor OLT at our institution from 2005-2012 were reviewed, and 123 OLT ABS patients receiving stent therapy were identified...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29055918/rotational-thromboelastometry-or-conventional-coagulation-tests-in-liver-transplantation-comparing-blood-loss-transfusions-and-cost
#13
Laura Smart, Khalid Mumtaz, Danielle Scharpf, Nicole O'Bleness Gray, Daniel Traetow, Sylvester Black, Anthony J Michaels, Elmahdi Elkhammas, Robert Kirkpatrick, A James Hanje
INTRODUCTION: Orthotopic liver transplantation (OLT) can be associated with significant bleeding requiring multiple blood product transfusions. Rotational thromboelastometry (ROTEM) is a point-of-care device that has been used to monitor coagulation during OLT. Whether it reduces blood loss/transfusions during OLT remains controversial. MATERIALS AND METHODS: We aim to compare ROTEM with conventional coagulation tests (aPTT, PT, INR, platelet count, fibrinogen) to guide transfusion of platelets, cryoprecipitate, and fresh frozen plasma (FFP) during OLT over 3 years...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29041144/olt-centralized-sampling-frequency-offset-compensation-scheme-for-ofdm-pon
#14
Ming Chen, Hui Zhou, Zhiwei Zheng, Rui Deng, Qinghui Chen, Miao Peng, Cuiwei Liu, Jing He, Lin Chen, Xionggui Tang
We propose an optical line terminal (OLT)-centralized sampling frequency offset (SFO) compensation scheme for adaptively-modulated OFDM-PON systems. By using the proposed SFO scheme, the phase rotation and inter-symbol interference (ISI) caused by SFOs between OLT and multiple optical network units (ONUs) can be centrally compensated in the OLT, which reduces the complexity of ONUs. Firstly, the optimal fast Fourier transform (FFT) size is identified in the intensity-modulated and direct-detection (IMDD) OFDM system in the presence of SFO...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29019813/contemporary-policies-regarding-alcohol-and-marijuana-use-among-liver-transplant-programs-in-the-united-states
#15
Jiaming Zhu, Ping-Yu Chen, Marla Frankel, Robert R Selby, Tse-Ling Fong
BACKGROUND: Alcoholic liver disease is a common indication for liver transplantation (OLT). Although OLT has been shown to confer survival benefit to patients with acute alcoholic hepatitis (AAH), historically most programs require a 6-month abstinence period prior to OLT which excludes patients with AAH. Marijuana has become legal in more than half the states in the United States. This survey of liver transplant programs was conducted to evaluate current policies regarding alcohol, marijuana and methadone use...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29018070/hypothermic-oxygenated-machine-perfusion-hope-for-orthotopic-liver-transplantation-of-human-liver-allografts-from-extended-criteria-donors-ecd-in-donation-after-brain-death-dbd-a-prospective-multicentre-randomised-controlled-trial-hope-ecd-dbd
#16
Zoltan Czigany, Wenzel Schöning, Tom Florian Ulmer, Jan Bednarsch, Iakovos Amygdalos, Thorsten Cramer, Xavier Rogiers, Irinel Popescu, Florin Botea, Jiří Froněk, Daniela Kroy, Alexander Koch, Frank Tacke, Christian Trautwein, Rene H Tolba, Marc Hein, Ger H Koek, Cornelis H C Dejong, Ulf Peter Neumann, Georg Lurje
INTRODUCTION: Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. In an attempt to improve the availability of donor allografts and reduce waiting list mortality, graft acceptance criteria were extended increasingly over the decades. The use of extended criteria donor (ECD) allografts is associated with a higher incidence of primary graft non-function and/or delayed graft function. As such, several strategies have been developed aiming at reconditioning poor quality ECD liver allografts...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29016192/added-value-of-preoperative-computed-tomography-for-determining-cartilage-degeneration-in-patients-with-osteochondral-lesions-of-the-talar-dome
#17
Tomoyuki Nakasa, Yasunari Ikuta, Masahiro Yoshikawa, Mikiya Sawa, Yusuke Tsuyuguchi, Nobuo Adachi
BACKGROUND: Osteochondral lesions of the talar dome (OLTs) involve the articular cartilage and subchondral bone. The subchondral bone plate (SBP) plays a crucial role in cartilage metabolism, and computed tomography (CT) can provide more precise information on subchondral bone. CT image prediction of the histological findings on OLT will be useful to determine the most appropriate therapeutic strategy. PURPOSE: To evaluate the unique features of the CT findings that relate to the condition of the articular cartilage in OLT...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28991277/liver-transplantation-center-in-m%C3%A3-xico-with-low-volume-and-excellent-results
#18
Mario Vilatobá, Miguel Ángel Mercado, Alan Gabriel Contreras-Saldivar, Rafael Paulino Leal-Villalpando, Jorge Zamudio-Bautista, Ignacio García-Juárez, Armando Gamboa-Domínguez
Orthotopic liver transplantation (OLT) is the treatment of choice for end stage liver disease. Many studies show an inverse relationship between the number of procedures and operative mortality. The objective of the study is to show the results of our center and determine if it can have comparable results to high volumen centers. This is a retrospective study which analyzed the information of patients with OLT at our institution from 1985 to December 31, 2012. Depending on date of transplantation, the study was divided into three stages...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28989060/metroticket-2-0-model-for-analysis-of-competing-risks-of-death-following-liver-transplantation-for-hepatocellular-carcinoma
#19
Vincenzo Mazzaferro, Carlo Sposito, Jian Zhou, Antonio D Pinna, Luciano De Carlis, Jia Fan, Matteo Cescon, Stefano Di Sandro, He Yi-Feng, Andrea Lauterio, Marco Bongini, Alessandro Cucchetti
BACKGROUND & AIMS: Outcomes of liver transplantation for hepatocellular carcinoma (HCC) are determined by cancer-related and non-related events. Treatments for hepatitis C virus (HCV) infection have reduced non-cancer events among patients receiving liver transplants, so reducing HCC-related death might be an actionable endpoint. We performed a competing risk analysis to evaluate factors associated with survival of patients with HCC, and developed a prognostic model based on features of HCC patients before liver transplantation...
October 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28988703/cost-of-achieving-equivalent-outcomes-in-sicker-patients-after-liver-transplant
#20
Vikrom K Dhar, Koffi Wima, Young Kim, Richard S Hoehn, Andrew D Jung, Audrey E Ertel, Tayyab S Diwan, Flavio Paterno, Shimul A Shah
BACKGROUND: We aimed to characterize variability in cost after straightforward orthotopic liver transplant (OLT). METHODS: Using the University HealthSystem Consortium and Scientific Registry of Transplant Recipients databases, we identified patients who underwent OLT between 2011 and 2014. Patients meeting criteria for straightforward OLT, defined as length of stay < 14 days with discharge to home, were selected (n = 5763) and grouped into tertiles (low, medium, high) according to cost of perioperative stay...
October 4, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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