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https://www.readbyqxmd.com/read/29764373/a-subclinical-high-tricuspid-regurgitation-pressure-gradient-independent-of-the-mean-pulmonary-artery-pressure-is-a-risk-factor-for-the-survival-after-living-donor-liver-transplantation
#1
Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike, Fusao Ikeda, Hideki Onishi, Hidenori Shiraha, Shinichiro Nakamura, Hiroshi Morimatsu, Hiroshi Ito, Toshiyoshi Fujiwara, Takahito Yagi, Hiroyuki Okada
BACKGROUND: Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after orthotopic liver transplantation (OLT), as the congestive pressure affects the grafted liver, while subclinical pulmonary hypertension (PH) has been acknowledged as a non-risk factor for deceased donor OLT. Given that PH measurement requires cardiac catheterization, the tricuspid regurgitation pressure gradient (TRPG) measured by echocardiography is used to screen for PH and congestive pressure to the liver...
May 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29749104/soluble-fibrinogen-like-protein-2-ameliorates-acute-rejection-of-liver-transplantation-in-rat-via-inducing-kupffer-cells-m2-polarization
#2
Guangrui Pan, Zhengfei Zhao, Chengyong Tang, Liuyue Ding, Zhongtang Li, Daofeng Zheng, Liang Zong, Zhongjun Wu
Soluble fibrinogen-like protein 2 (sFGL2) could ameliorate acute rejection (AR) in rat cardiac transplantation. However, the role of sFGL2 in AR of liver transplantation has not been addressed. In this study, we found that FGL2 was upregulated in rat orthotropic liver transplantation (OLT) models of tolerance and positive correlation with the frequency of M2 Kupffer cells (KCs). Gain-of-function experiments in vitro showed that sFGL2 promoted the secretion of anti-inflammatory cytokines (IL-10, TGF-β) and the expression of CD206, and inhibited the activities of STAT1 and NF-κB signaling pathway...
May 10, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29745020/post-transplant-muscle-mass-measured-by-urinary-creatinine-excretion-rate-predicts-long-term-outcomes-after-liver-transplantation
#3
Suzanne P Stam, Maryse Cj Osté, Michele F Eisenga, Hans Blokzijl, Aad P van den Berg, Stephan Jl Bakker, Vincent E de Meijer
Long-term survival in orthotopic liver transplant (OLT) recipients remains impaired due to many contributing factors, among which a low pre-transplant muscle mass (or sarcopenia). However, influence of post-transplant muscle mass on survival is currently unknown. We hypothesized that post-transplant urinary creatinine excretion rate (CER), an established non-invasive marker of total body muscle mass, is associated with long-term survival after OLT. In a single-center cohort study of 382 adult OLT recipients, mean±standard deviation CER at 1 year post-transplantation was 13...
May 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29743797/natural-history-of-cirrhosis-of-liver-after-first-decompensation-a-prospective-study-in-india
#4
Apurva S Shah, Deepak N Amarapurkar
Background and aims: As liver cirrhosis is a dynamic condition, it is possible to improve survival in decompensated cirrhosis. Hence, we planned a prospective study to determine the natural history of cirrhosis after first decompensation. Methods: We enrolled all patients of liver cirrhosis who presented with first episode of decompensation defined by the presence of ascites, either overt or detected by Ultrasonography (UD), Gastroesophageal Variceal Bleeding (GEVB), and Hepatic Encephalopathy (HE)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743796/increased-incidence-of-post-transplant-lymphoproliferative-disorder-in-autoimmune-liver-disease-an-irish-national-experience
#5
Ahmed Abu-Shanab, Yasser Ged, Naeem Ullah, Diarmaid Houlihan, Aiden McCormick
Background: Post-Transplant Lymphoproliferative Disorder (PTLD) is a well-recognized complication post solid organs transplant. PTLD represents a broad spectrum of abnormalities ranging from an infectious mononucleosis like illness to malignant lymphoma. Methods: A retrospective study was performed by collecting data of orthotopic liver transplant (OLT) patients in the National Liver Unit in Ireland from December 1993 to December 2014. Data was analyzed to identify PTLD patients and determine their demographic details, the indication for liver transplant, presenting symptoms, immunosuppression regimens, Epstein"Barr virus (EBV) status and PTLD outcome...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29729113/multicenter-study-of-staging-and-therapeutic-predictors-of-hepatocellular-carcinoma-recurrence-following-transplantation
#6
Theodore H Welling, Kevin Eddinger, Kristen Carrier, Danting Zhu, Tyler Kleaveland, Derek E Moore, Douglas E Schaubel, Peter L Abt
Orthotopic liver transplantation (OLT) and resection are effective treatments for hepatocellular carcinoma (HCC). However, optimizing OLT and limiting HCC recurrence remains a vexing problem. New HCC MELD and allocation algorithms provide greater observation of HCC patients, many while receiving local-regional treatments. Potential benefits of local-regional treatment for limiting HCC recurrence post-OLT remain incompletely understood. Therefore we aimed to define HCC specific prognostic factors affecting recurrence in a contemporary, multi-center cohort of HCC patients undergoing OLT and specifically whether local-regional therapies limited recurrence...
May 5, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29715769/300-gb-s-im-dd-based-sdm-wdm-pon-with-laserless-onus
#7
Fangdi Bao, Toshio Morioka, Leif K Oxenløwe, Hao Hu
A low-cost, high-speed SDM-WDM-PON architecture is proposed by using a multi-core fiber (MCF) and intensity modulation/directly detection (IM/DD). One of the MCF cores is used for sending laser sources from optical line terminal (OLT) to optical network unit (ONU), thus facilitating laserless and colorless ONUs, and providing ease of network management and maintenance. In addition, the wavelengths of the ONUs are controlled on the OLT side, which also enables flexible optical networks. Thanks to the low inter-core crosstalk of a MCF, downstream (DS) and upstream (US) signals are transmitted independently in different cores of the MCF, not only increasing the aggregated capacity but also avoiding the Rayleigh backscattering noise...
April 2, 2018: Optics Express
https://www.readbyqxmd.com/read/29707629/comparison-of-the-warmcloud-and-bair-hugger-warming-devices-for-the-prevention-of-intraoperative-hypothermia-in-patients-undergoing-orthotopic-liver-transplantation-a-randomized-clinical-trial
#8
Brett Pearce, Linda Mattheyse, Louise Ellard, Fiona Desmond, Param Pillai, Laurence Weinberg
Background: The avoidance of hypothermia is vital during prolonged and open surgery to improve patient outcomes. Hypothermia is particularly common during orthotopic liver transplantation (OLT) and associated with undesirable physiological effects that can adversely impact on perioperative morbidity. The KanMed WarmCloud (Bromma, Sweden) is a revolutionary, closed-loop, warm-air heating mattress developed to maintain normothermia and prevent pressure sores during major surgery. The clinical effectiveness of the WarmCloud device during OLT is unknown...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29701070/the-role-of-3d-reconstruction-true-volume-analysis-in-osteochondral-lesions-of-the-talus-a-case-series
#9
Kempland C Walley, Tyler A Gonzalez, Ryan Callahan, Aubree Fairfull, Evan Roush, Kaitlin L Saloky, Paul J Juliano, Gregory S Lewis, Michael C Aynardi
BACKGROUND: Evaluation and management of osteochondral lesions of the talus (OLTs) often warrant advanced imaging studies, especially in revision or cases with cystic defects. It is possible that orthopedic surgeons may overestimate the size and misinterpret the morphology of OLT from conventional computed tomography (CT), thereby influencing treatment strategies. The purpose of this study was to determine the utility of a novel means to estimate the true-volume of OLTs using 3D reconstructed images and volume analysis...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29698981/partial-hemiresurfacing-of-osteochondral-defects-of-the-talus-surgical-technique-and-preliminary-report-from-four-patient
#10
Sascha Beck, André Busch, Christoph Zilkens, Sebastian Warwas, Marcus Jäger
BACKGROUND: Osteochondral lesions of the medial talus (OLT) frequently lead to chronic ankle pain and osteoarthritis. Arthroscopic debridement, subchondral bone stimulation by drilling, and microfracturing are options for primary therapy in small lesions. In larger lesions, restoration of the talar dome contour seems to be a mandatory course of action. METHODS: In a case series, we followed up four patients being treated with a focal resurfacing prosthetic due to large osteochondral talar lesions...
April 26, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29696318/microfracture-provides-better-clinical-results-than-debridement-in-the-treatment-of-acute-talar-osteochondral-lesions-using-arthroscopic-assisted-fixation-of-acute-ankle-fractures
#11
Altuğ Duramaz, Emre Baca
PURPOSE: Ankle arthroscopy is a useful tool for detection and treatment of accompanying intraarticular pathologies in acute ankle fractures. The purpose of this study was to compare the treatment results of talus osteochondral lesions (OLT) with debridement and microfracture in arthroscopy assisted surgery of acute ankle fractures. METHODS: Eleven consecutive patients who were treated with arthroscopic acute debridement and 14 consecutive patients who were treated with arthroscopic acute microfracture in the treatment of ankle fracture were included in the study...
April 25, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29692377/predictive-value-of-serum-creatinine-blood-urea-nitrogen-uric-acid-and-%C3%AE-2-microglobulin-in-the-evaluation-of-acute-kidney-injury-after-orthotopic-liver-transplantation
#12
Hai-Yang Lu, Xin-Yu Ning, Ying-Qi Chen, Shu-Jun Han, Ping Chi, Sai-Nan Zhu, Yun Yue
Background: As a major complication after orthotopic liver transplantation (OLT), the occurrence of acute kidney injury (AKI) is frequently defined by serum creatinine (Cr); however, the accuracy of commonly used blood urea nitrogen (BUN), uric acid (UA), and β2 -microglobulin (β2 -MG) remains to be explored. This retrospective study compared the accuracy of these parameters for post-OLT AKI evaluation. Methods: Patients who underwent OLT in three centers between July 2003 and December 2013 were enrolled...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29652193/relationship-between-bone-marrow-lesions-on-mri-and-cartilage-degeneration-in-osteochondral-lesions-of-the-talar-dome
#13
Tomoyuki Nakasa, Yasunari Ikuta, Mikiya Sawa, Masahiro Yoshikawa, Yusuke Tsuyuguchi, Yuki Ota, Munekazu Kanemitsu, Nobuo Adachi
BACKGROUND: In the evaluation of osteochondral lesions of the talar dome (OLT), bone marrow lesions (BML) are commonly observed in the subchondral bone on magnetic resonance imaging (MRI). However, the significance of BML, such as the histology of the overlying cartilage, is still unclear. The purpose of this study was to investigate the relationship between the BML and cartilage degeneration in OLT. METHODS: Thirty-three ankles with OLT were included in this study...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29620252/tim%C3%A2-4-blockade-of-kcs-combined-with-exogenous-tgf%C3%A2-%C3%AE-injection-helps-to-reverse-acute-rejection-and-prolong-the-survival-rate-of-mice-receiving-liver-allografts
#14
Hao Wu, Xuesong Xu, Jinzheng Li, Jianping Gong, Min Li
An acute reaction response (AR) following liver transplantation (LT) is caused by immune responses that are primarily mediated by T lymphocytes. Kupffer cells (KCs) are the largest antigen presenting cell (APC) group in vivo and are the primary modulators of the inflammatory or tolerogenic immune response in liver tissues. T cell immunoglobulin‑domain and mucin‑domain-4 (TIM‑4), the only TIM protein not expressed on T cells, is expressed on APCs; suggesting that it mediates the various immune responses...
March 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29617450/limb-remote-ischemic-conditioning-of-the-recipient-protects-the-liver-in-a-rat-model-of-arterialized-orthotopic-liver-transplantation
#15
Zoltan Czigany, Christian Bleilevens, Christian Beckers, Christian Stoppe, Michaela Möhring, Andras Fülöp, Attila Szijarto, Georg Lurje, Ulf P Neumann, René H Tolba
BACKGROUND: Ischemic-reperfusion (IR) injury still represents a major concern in clinical transplantation, especially in the era of extreme organ shortage and extended criteria donor organs. In the present study we aimed to investigate the hepatoprotective effects of remote ischemic conditioning (RIC) in a rat model of arterialized orthotopic liver transplantation (OLT). METHODS: Male Lewis rats were used (n = 144 / 72 OLT cases; 240-340g) as donors and recipients...
2018: PloS One
https://www.readbyqxmd.com/read/29611203/stabilisation-of-acute-on-chronic-liver-failure-patients-before-liver-transplantation-predicts-post-transplant-survival
#16
P Huebener, M R Sterneck, K Bangert, A Drolz, A W Lohse, S Kluge, L Fischer, V Fuhrmann
BACKGROUND: Acute-on-chronic liver failure (ACLF) is a severe complication of liver cirrhosis associated with excess short-term mortality rates. Orthotopic liver transplantation (OLT) is a potentially life-saving therapeutic modality for acute-on-chronic liver failure patients, but selection of transplant candidates with an acceptable post-transplant outcome is difficult. OBJECTIVE: To assess the risk of liver transplantation in patients with ACLF, and to determine parameters that predict post-transplant survival in this patient cohort...
April 2, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29608499/diagnosis-treatment-and-management-of-orthotopic-liver-transplant-candidates-with-portopulmonary-hypertension
#17
Anna Koulava, Abdallah Sannani, Avi Levine, Chhaya Aggarwal Gupta, Sarina Khanal, William Frishman, Roxana Bodin, David C Wolf, William Aronow, Gregg M Lanier
Portopulmonary hypertension (POPH) is seen in 5-8% of orthotopic liver transplantation (OLT) candidates and has significant implications for clinical outcomes. POPH is characterized by vasoconstriction and remodeling of the pulmonary vasculature. It is exacerbated by the hyperdynamic circulation that is common in advanced liver disease. Screening all OLT candidates with transthoracic echocardiography to assess pulmonary pressures and right ventricular function is crucial, as clinical symptoms alone are not reliable...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29608158/a-rat-model-of-orthotopic-liver-transplantation-using-a-novel-magnetic-anastomosis-technique-for-suprahepatic-vena-cava-reconstruction
#18
Lifei Yang, Jianwen Lu, Yue Wang, Mei Zhang, Yuan Shi, Shasha Wei, Peng Liu, Zheng Wu, Yi Lv, Rongqian Wu
The rat model of orthotopic liver transplantation (OLT) is essential for transplant research. It is a very sophisticated animal model and requires a steep learning curve. The introduction of the cuff technique for anastomosis of the portal vein (PV) and infrahepatic vena cava (IHVC) has significantly simplified the transplant procedure in rats. However, due to the short anterior wall of the recipients' suprahepatic vena cava (SHVC), the cuff technique is very difficult to use for the reconstruction of the SHVC...
March 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29587453/low-serum-levels-of-dihydro-ceramides-reflect-liver-graft-dysfunction-in-a-real-world-cohort-of-patients-post-liver-transplantation
#19
Victoria Therese Mücke, Janis Gerharz, Katja Jakobi, Dominique Thomas, Nerea Ferreirós Bouzas, Marcus Maximilian Mücke, Sven Trötschler, Nina Weiler, Martin-Walter Welker, Stefan Zeuzem, Josef Pfeilschifter, Georgios Grammatikos
Patients after orthopic liver transplantation (OLT) are at risk of developing graft dysfunction. Sphingolipids (SL's) have been identified to play a pivotal role in the regulation of hepatocellular apoptosis, inflammation and immunity. We aimed to investigate the serum SL profile in a prospective real-world cohort of post-OLT patients. From October 2015 until July 2016, 149 well-characterized post-OLT patients were analyzed. SL's were assessed in serum probes via Liquid Chromatography/Tandem Mass Spectrometry...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29582098/high-reported-rate-of-return-to-play-following-bone-marrow-stimulation-for-osteochondral-lesions-of-the-talus
#20
REVIEW
Eoghan T Hurley, Yoshiharu Shimozono, Niall P McGoldrick, Charles L Myerson, Youichi Yasui, John G Kennedy
PURPOSE: The purpose of this study is to systematically review the literature and to evaluate the reported rehabilitation protocols, return to play guidelines and subsequent rates and timing of return to play following bone marrow stimulation (BMS) for osteochondral lesions of the talus (OLT). METHODS: MEDLINE, EMBASE and the Cochrane Library were searched according to the PRISMA guidelines in September 2017. The rate and timing of return to play was assessed. The rehabilitation protocols were recorded, including time to start range of motion, partial weight-bearing and complete weight-bearing...
March 26, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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