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Alessandra Torina, Giuliana Guggino, Marco Pio La Manna, Guido Sireci
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types...
February 1, 2018: International Journal of Molecular Sciences
Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Federico Pierella, Flavio Del Bianco, Vincenzo Gentile, Ida Silvestri, Susanna Cattarino
Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor involved in prostate cancer (PC) pathogenesis and progression. This review critically analyzes the role of inflammation as a prognostic factor for progression and aggressiveness of PC. We verified the last 10 years literature data on the association between inflammation and PC aggressiveness, or PC response to therapies...
2016: Journal of Inflammation
Maurizio Bruschi, Andrea Petretto, Roberta Bertelli, Maricla Galetti, Alice Bonanni, Federico Pratesi, Paola Migliorini, Giovanni Candiano, Augusto Vaglio, Gian Marco Ghiggeri
Basic research is showing new mechanisms involved in early immune responses and Neutrophil Extracellular Trap (NET) formation (or NETosis) is of key importance as first line defense against bacteria, virus and protozoa. Enzymatic modification of arginine in citrulline in histones is the prerequisite of NETosis being it necessary for decondensation and extrusion of DNA from cells; it is conceivable that other post translational modifications may occur during this event. There is consensus in considering that post translational modified proteins may elicit an autoimmune response that leads to the formation of autoantibodies...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
Jorge Vega, Francisco J Guarda
Pauci-immune glomerulonephritis in systemic vasculitides usually have anti-neuthrophil cytoplasmic antibodies (ANCA). However, vasculitides of large vessels such as Takayasu's and giant cell (temporal) arteritis do not. Exceptionally ANCA(+) small vessel vasculitides are associated with large vessel vasculitis. It may be a coincidence or both vasculitides have a common pathogenesis. We report a 30 years old woman on hemodialysis due to a chronic glomerulonephritis ANCA(+) diagnosed nine years ago. Eight years later, she presented with an aortitis with severe stenosis of distal aorta and vasculitis of left subclavian artery...
September 2015: Revista Médica de Chile
Rossana García-Fernández, Markus Perbandt, Dirk Rehders, Patrick Ziegelmüller, Nicolas Piganeau, Ulrich Hahn, Christian Betzel, María de Los Ángeles Chávez, Lars Redecke
Elastase-like enzymes are involved in important diseases such as acute pancreatitis, chronic inflammatory lung diseases, and cancer. Structural insights into their interaction with specific inhibitors will contribute to the development of novel anti-elastase compounds that resist rapid oxidation and proteolysis. Proteinaceous Kunitz-type inhibitors homologous to the bovine pancreatic trypsin inhibitor (BPTI) provide a suitable scaffold, but the structural aspects of their interaction with elastase-like enzymes have not been elucidated...
May 29, 2015: Journal of Biological Chemistry
Alireza Ostadrahimi, Jamal Eivazi Ziaei, Ali Esfahani, Mohammad Asghari Jafarabadi, Aliakbar Movassaghpourakbari, Nazila Farrin
BACKGROUND: Breast cancer is the most common female malignancy in the world. Beta glucan can be a hematopoietic and an immune modulator agent in cancer patients. The aim of this trial was to determine the effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy. MATERIALS AND METHODS: This randomized double-blind placebo-controlled clinical trial was conducted on 30 women with breast carcinoma aged 28-65 years...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Giuseppe Cicco, P C Panzera, G Catalano, V Memeo
There are many interesting aspects regarding hemorheology and tissue oxygenation in organ transplantation (such as liver, kidney, heart, etc.). The ischemia-reperfusion injury syndrome is a very important problem. Much damage in organs appears to be induced by reperfusion injury syndrome. In fact, not only immunological etiopathogenesis but also biochemically-mediated microcirculation alterations can modulate the organ damage induced by ischemia-reperfusion injury during organ transplantation. During ischemia-reperfusion injury, xanthine oxidase activity, the increase in oxygen free-radicals, and the activation of neuthrophils are all very important...
2005: Advances in Experimental Medicine and Biology
Rajko Milosević, Marina Bogunović, Nebojsa Antonijević
Antithyreoid drugs are known causative agents of agranulocytosis and, in rare cases, aplastic anaemia as well. This is a case report of a female patient with secondary aplastic anaemia developed two years after continual use of thiamazole. She suffered from exhaustion and massive epistaxis. Physical examination revealed pale skin and mucous membranes, skin hematomas (body and legs) and high body temperature--39 degrees C. At admission, her blood film revealed pancytopaenia with 75 g/l hemoglobin concentration, 1...
May 2004: Srpski Arhiv za Celokupno Lekarstvo
V V Anikin, M N Kalinkin, Iu L Voronaia
Nonspecific resistance (peripheral leukogram, integral leukocytic indices, types of adaptive responses, and phagocytosis) and immunological responsiveness (T- and B-immunity systems) were studied in 30 patients with chronic coronary heart disease (CHD) concurrent with various cardiac arrhythmia. In the patients, there was an increase in the relative counts of band neutrophils and lymphocytes, a decrease in the counts of segmented granulocytes and monocytes. A number of integral leukocytic indices (leukocytic index, lymphocytic-and-granulocytic index, total index, and deviation index) were increased and the neuthrophil/lymphocyte ratio was decreased...
2003: Klinicheskaia Meditsina
Elsa Callén, María J Ramírez, Amadeu Creus, Ricard Marcos, Juan J Ortega, Teresa Olivé, Isabel Badell, Jordi Surrallés
Fanconi anemia (FA) is a chromosome instability syndrome, characterized by progressive pancytopenia and cancer susceptibility. Other cellular features of FA cells are hypersensitivity to DNA cross-linking agents and accelerated telomere shortening. We have quantified overall genome chromosome fragility and euploidy as well as chromosomes 7 and 8 aneuploidy in peripheral blood lymphocytes from a group of FA patients and age-matched controls that were previously measured for telomere length. The haematology of FA samples were also characterized in terms of whole blood cell, neuthrophil and platelet counts, transfusion dependency, requirement of androgens, cortico-steroids or bone marrow transplantation, and the development of bone marrow clonal cytogenetic abnormalities, myelodysplastic syndrome or acute myeloid leukemia...
July 25, 2002: Mutation Research
H Corrales Padilla
The histopathologic alterations of the allergic cutaneous vasculitis (fibrinoid necrosis of the walls of the small blood vessels with infiltration of neuthrophils in Karyorrexis) is seen in several entities. It is possible to divide such entities in two groups: a) Primitive allergic vasculitis in which the vascular lesion is dominant and. b) Secondary allergic vasculitis in which the vascular alterations, not constant, are integrants of variable histopathologic conditions. Many classifications have deen done on clinical and pathological bases...
1975: Medicina Cutánea Ibero-latino-americana
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