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https://www.readbyqxmd.com/read/28344923/impact-of-drug-treatment-at-neonatal-ages-on-variability-of-drug-metabolism-and-drug-drug-interactions-in-adult-life
#1
Stephanie Piekos, Chad Pope, Austin Ferrara, Xiao-Bo Zhong
PURPOSE OF REVIEW: As the number of patients taking more than one medication concurrently continues to increase, predicting and preventing drug-drug interactions (DDIs) is now more important than ever. Administration of one drug can cause changes in the expression and activity of drug metabolizing enzymes (DMEs) and alter the efficacy or toxicity of other medications that are substrates for these enzymes, resulting in a DDI. In today's medical practice, potential DDIs are evaluated based on the current medications a patient is taking with little regard to drugs the patient has been exposed to in the past...
February 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/28328044/characterization-of-dissolved-and-particulate-phases-of-water-accommodated-fractions-used-to-conduct-aquatic-toxicity-testing-in-support-of-the-deepwater-horizon-natural-resource-damage-assessment
#2
Heather P Forth, Carys L Mitchelmore, Jeffrey M Morris, Claire R Lay, Joshua Lipton
In response to the Deepwater Horizon (DWH) oil spill, the Natural Resource Trustees implemented a toxicity testing program that included four different DWH oils that ranged from fresh to weathered, and three different oil-in-water preparation methods (including one that used the chemical dispersant Corexit 9500) to prepare a total of 12 chemically unique water accommodated fractions (WAFs). We determined how the different WAF preparation methods, WAF concentrations, and oil types influenced the chemical composition and concentration of polycyclic aromatic hydrocarbons (PAHs) in the dissolved and particulate phases over time periods used in standard toxicity tests...
March 22, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28325425/treatment-of-scaphotrapeziotrapezoid-osteoarthritis-with-the-pyrocardan-%C3%A2-implant-results-with-a-minimum-follow-up-of-2-years
#3
E Gauthier, M-V Truffandier, E Gaisne, P Bellemère
The aim of this study was to report the results of arthroplasty using a mobile pyrocarbon implant (Pyrocardan(®)) for isolated scaphotrapeziotrapezoid (STT) osteoarthritis. The hypothesis was that this arthroplasty leads to functional improvement without carpal instability. Twenty patients (22 implants) were included with a minimum follow-up of 2 years and an average age of 59.6 years. Outcome criteria were pain (VAS scale), QuickDASH and PRWE scores, strength (grip and pinch), wrist mobility, the Kapandji index, carpal height and the capitolunar angle measured on X-rays...
April 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28324202/the-influence-of-surgical-approach-on-postoperative-pelvic-tilt-after-total-hip-arthroplasty
#4
Daisuke Inoue, Tamon Kabata, Yoshitomo Kajino, Tadashi Taga, Kazuhiro Hasegawa, Takashi Yamamoto, Tomoharu Takagi, Takaaki Ohmori, Hiroyuki Tsuchiya
BACKGROUND: Past reports have shown the tendency of posterior pelvic tilt to increase over time after total hip arthroplasty (THA). We have hypothesized that the volume and extent of released joint capsule may influence the change in postoperative pelvic tilt. This study was conducted to ascertain whether surgical approach during THA (posterior or anterior) has an effect on postoperative changes in pelvic tilt. METHODS: We conducted a retrospective review of 81 hips in 60 patients...
March 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28323247/changes-of-the-bone-structure-after-cap-resurfacing-arthroplasty-of-thehumeral-head
#5
Lars V von Engelhardt, Michael Hahn, Thorsten Schulz, Klaus Peikenkamp, Joerg Jerosch
INTRODUCTION: Although humeral head resurfacing with a cap is relatively common in clinical practice, clinical studies about the changes of the bone are rare. The aim of this study was to analyse qualitative and quantitative changes of the bone after cup arthroplasty. Our hypothesis is that the implant leads to a new functional load with remarkable changes of the bone underneath the cap. MATERIAL AND METHODS: Overall, 12 explanted caps with adherent bone tissues, retrieved at the revision surgery, were collected for histological examination...
March 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28317000/surgical-treatment-algorithms-for-post-burn-contractures
#6
REVIEW
Kenji Hayashida, Sadanori Akita
Burn contractures produce restrictions in motion and unacceptable aesthetic results, frequently with persistent wounds. Proper planning and tissue selection are essential to minimize donor site morbidity optimizing outcomes. The principle of burn reconstructive surgery requires that the defects after release should be replaced with donor tissues which have matching texture and color as well as enough pliability. Autologous skin grafting or flap surgeries meet these criteria to replace scar tissues and resurface the subsequent to post-released scar defects...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28299718/have-the-causes-of-revision-for-total-and-unicompartmental-knee-arthroplasties-changed-during-the-past-two-decades
#7
Gro S Dyrhovden, Stein Håkon L Lygre, Mona Badawy, Øystein Gøthesen, Ove Furnes
BACKGROUND: Revisions after knee arthroplasty are expected to increase, and the epidemiology of failure mechanisms is changing as new implants, technology, and surgical techniques evolve. QUESTIONS/PURPOSES: (1) Was there improvement in survival for TKA and unicompartmental knee arthroplasty (UKA) when comparing two consecutive 11-year periods with similar followups in a national registry? (2) Were there changes in the causes of revision during the two times? (3) Could the changes in revision causes be attributed to patient or implant characteristics? METHODS: A total of 60,623 TKAs (2426 revisions) and 7648 UKAs (725 revisions) were selected from the Norwegian Arthroplasty Register and analyzed based on year of primary surgery: 1994 to 2004 (Period 1) and 2005 to 2015 (Period 2)...
March 15, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28297060/drug-eluting-grafts-for-hemodialysis-access
#8
Marc Glickman
The development of new methods for drug elution of graft material, biofiber films and resurfacing of prosthetic graft surfaces offers new opportunities for improvement of graft function in arteriovenous (AV) access. Three areas of research include developing grafts that reduce the development of neointimal hyperplasia, reducing infection and reducing thrombogenicity. The only drug eluting graft presently being used, is the heparin coated expanded polytetrafluoroethylene (ePTFE) graft, which has been shown to decrease the incidence of early thrombosis...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28295569/simultaneous-vascularized-bony-reconstruction-of-the-maxilla-and-mandible-using-a-single-fibula-a-case-report
#9
Alexander F Mericli, Jonathan S Friedstat, Edward I Chang, Matthew M Hanasono
Simultaneous maxillary and mandibular reconstruction is exceedingly rare. These are complicated cases, requiring consideration of multiple variables: defect components, donor site morbidity, recipient vessels, and so forth. We describe a unique case of secondary maxillary/mandibular reconstruction in a 59-year-old male. The original defect was created after removal of a buccal squamous cell carcinoma, involving the external cheek skin, buccal mucosa, right mandibular body, and right inferior maxilla; a free vertical rectus abdominis musculocutaneous flap was used for the initial reconstruction...
March 2017: Microsurgery
https://www.readbyqxmd.com/read/28295276/dreaming-woman-image-place-and-the-aesthetics-of-exile
#10
Rachel Greenspan
Looking closely at an Argentine dream interpretation column published in a popular women's magazine from 1948 to 1951, this article examines the role of the dream image in shaping psychoanalytic discourse on femininity and national identity. The column, 'Psychoanalysis Will Help You,' emerged during Juan Domingo Perón's first presidency, featuring verbal interpretations written under the pen name 'Richard Rest,' as well as surreal photomontages by Grete Stern, a German-born, Bauhaus-trained photographer living in exile since 1936...
March 14, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28292408/hydrothermal-duodenal-mucosal-resurfacing-role-in-the-treatment-of-metabolic-disease
#11
REVIEW
Alan D Cherrington, Harith Rajagopalan, David Maggs, Jacques Devière
The duodenum has become recognized as a metabolic signaling center that is involved in regulating insulin action and, therefore, insulin resistance states such as type 2 diabetes. Bariatric surgery and other manipulations of the upper intestine, in particular the duodenum, have shown that limiting nutrient exposure or contact in this key region exerts powerful metabolic effects. Early human clinical trial data suggest that endoscopic hydrothermal duodenal mucosal resurfacing is well tolerated in human subjects and has an acceptable safety profile...
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28292407/small-bowel-target-devices-and-techniques
#12
REVIEW
Steven A Edmundowicz
The small bowel is a prime target for bariatric and metabolic endoscopic therapies. New insights into the mechanisms of action of surgical therapies have led to new endoscopic therapies for obesity, type 2 diabetes mellitus, and the metabolic syndrome. The development of endoluminal sleeves that bypass the proximal duodenum have replicated some of the effects of surgical bypass procedures. The endoscopic dual-path enteral bypass has created new and treatment options for these conditions. Duodenal mucosal resurfacing offers significant promise for diabetes management...
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28291061/antimicrobial-prophylaxis-for-full-face-laser-resurfacing-in-transplant-recipients
#13
Brian P Hibler, Drew K Saylor, Peter Chin-Hong, Sarah T Arron
No abstract text is available yet for this article.
March 13, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28286072/organ-sparing-surgery-in-penile-cancer-a-systematic-review
#14
REVIEW
Mohamed H Kamel, Nabil Bissada, Renee Warford, Judy Farias, Rodney Davis
PURPOSE: Although penile cancer (PC) only represents 1% of all male cancers, the traditional treatment of total or subtotal penectomy carries devastating psychological and functional outcomes. Organ sparing surgery (OSS) in PC is an attractive option if it can provide satisfactory cancer control equivocal or near equivocal to standard techniques. In fact, these techniques are meeting increasing acceptance. Accordingly, the need to evaluate these options objectively is crucial in a comprehensive review is timely in order to increase awareness of these procedures, their applicability and provide guidance to the practicing urologist...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28275023/bilateral-fixation-of-a-periprosthetic-intertrochanteric-hip-fracture-below-birmingham-hip-resurfacing
#15
J Macdonald, R Pagoti, L Cusick
This case report involves a 59-year-old woman with a traumatic right intertrochanteric hip fracture below a previous Birmingham hip resurfacing (BHR). This woman had almost an identical fracture on the left hip 3 years before which was treated with a proximal femoral locking compression plate. Of note periprosthetic fractures following hip resurfacing are usually subcapital and treated with a revision or conservative management. We present an unusual surgical problem that has occurred twice in the same patient and has been treated effectively on both occasions using proximal femoral plating...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28274357/laser-and-light-based-treatments-of-acne-and-acne-scarring
#16
Macrene Alexiades
The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28273419/nanoassemblies-of-tissue-reactive-polyoxazoline-graft-copolymers-restore-the-lubrication-properties-of-degraded-cartilage
#17
Giulia Morgese, Emma Cavalli, Mischa Müller, Marcy Zenobi-Wong, Edmondo M Benetti
Osteoarthritis leads to an alteration in the composition of the synovial fluid, which is associated with an increase in friction and the progressive and irreversible destruction of the articular cartilage. In order to tackle this degenerative disease, there has been a growing interest in the medical field to establish effective, long-term treatments to restore cartilage lubrication after damage. Here we develop a series of graft-copolymers capable of assembling selectively on the degraded cartilage, resurfacing it, and restoring the lubricating properties of the native tissue...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28272152/aesthetic-reconstruction-of-the-frontotemporal-region-the-extended-a-t-plasty-a-workhorse-revisited
#18
Beniamino Brunetti, Stefania Tenna, Igor Poccia, Francesco Segreto, Paolo Persichetti
BACKGROUND: A-T plasty has long been a workhorse for defects located around the eyebrow or in the upper and lower lip. It allows like-with-like reconstruction with placement of the scars in natural creases or subunit junctions. In this article, the authors describe their refined technique to specifically address moderate to large size defects of the frontotemporal, preauricular, and zygomatic regions. MATERIALS AND METHODS: Thirty consecutive patients underwent reconstruction with the extended A-T plasty at our institution after skin cancer excision...
March 7, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28258135/unusual-versatility-revealed-by-a-filamentous-diazotrophic-cyanobacterium-anabaena-torulosa-for-its-survival-under-prolonged-uranium-exposure
#19
Celin Acharya, Pallavi Chandwadkar, Chandrani Nayak
Reports on cyanobacterial interactions with uranyl carbonate are rare. Here, we present an interesting succession of the metabolic responses employed by a marine, filamentous, diazotrophic cyanobacterium, Anabaena torulosa for its survival following prolonged exposure to uranyl carbonate extending up to 384 h at pH 7.8 under phosphate limited conditions. The cells sequestered uranium (U) in their polyphosphates on initial exposure to 100 μM uranyl carbonate for 24-28 h. Further incubation until 120 h resulted in (a) significant degradation of cellular polyphosphates causing extensive chlorosis and cell lysis, (b) akinete differentiation followed by (c) extracellular uranyl precipitation...
March 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28253943/the-importance-of-patellar-resurfacing-in-total-knee-arthroplasty-for-symptomatic-valgus-degenerative-deformity
#20
O B Vukadin, Z B Blagojević, Z Lj Baščarević, N S Slavković, V Stevanović, B D Vukomanović
PURPOSE OF THE STUDY Patellar surface replacement during total knee arthroplasty is still a matter of discussion among orthopedic surgeons. The purpose of this study was to examine possible benefits of patellar surface replacement in selected patients with symptomatic degenerative valgus deformity. We have not found any studies in the literature that compare the results of patella management solely for valgus or varus knee deformity nor those that compare both. MATERIAL AND METHODS Patients were randomly assigned to a group that would receive patellar surface replacement during total knee arthroplasty and a group of patients in whom total knee arthroplasty was performed without patellar surface replacement...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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