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https://www.readbyqxmd.com/read/29227471/inhibiting-mitochondrial-phosphate-transport-as-an-unexploited-antifungal-strategy
#1
Catherine A McLellan, Benjamin M Vincent, Norma V Solis, Alex K Lancaster, Lucas B Sullivan, Cathy L Hartland, Willmen Youngsaye, Scott G Filler, Luke Whitesell, Susan Lindquist
The development of effective antifungal therapeutics remains a formidable challenge because of the close evolutionary relationship between humans and fungi. Mitochondrial function may present an exploitable vulnerability because of its differential utilization in fungi and its pivotal roles in fungal morphogenesis, virulence, and drug resistance already demonstrated by others. We now report mechanistic characterization of ML316, a thiohydantoin that kills drug-resistant Candida species at nanomolar concentrations through fungal-selective inhibition of the mitochondrial phosphate carrier Mir1...
December 11, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29226269/evaluating-weathering-of-food-packaging-polyethylene-nano-clay-composites-release-of-nanoparticles-and-their-impacts
#2
Changseok Han, Amy Zhao, Eunice Varughese, E Sahle-Demessie
Nano-fillers are increasingly incorporated into polymeric materials to improve the mechanical, barrier or other matrix properties of nanocomposites used for consumer and industrial applications. However, over the life cycle, these nanocomposites could degrade due to exposure to environmental conditions, resulting in the release of embedded nanomaterials from the polymer matrix into the environment. This paper presents a rigorous study on the degradation and the release of nanomaterials from food packaging composites...
January 1, 2018: NanoImpact
https://www.readbyqxmd.com/read/29224214/facial-swelling-and-foreign-body-granulomatous-reaction-to-hyaluronic-acid-filler-in-the-setting-of-neratinib
#3
Brian P Hibler, Bernice Y Yan, Michael A Marchetti, Shabnam Momtahen, Klaus J Busam, Anthony M Rossi
Cosmetic injection of dermal fillers is common, with late complications increasingly recognized. Herein, we report a granulomatous reaction to hyaluronic acid filler occurring during the use of neratinib. A woman in her fifties, with metastatic adenocarcinoma of unknown primary involving the skin and bones, was referred for new-onset facial swelling. Notable past medical history included progression of disease on carboplatin/paclitaxel and a hemithyroidectomy for papillary thyroid cancer. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29223857/when-it-is-apt-to-adapt-flexible-reasoning-guides-children-s-use-of-talker-identity-and-disfluency-cues
#4
Justine M Thacker, Craig G Chambers, Susan A Graham
An eye-tracking methodology was used to examine whether children flexibly engage two voice-based cues, talker identity and disfluency, during language processing. Across two experiments, 5-year-olds (N = 58) were introduced to two characters with distinct color preferences. These characters then used fluent or disfluent instructions to refer to an object in a display containing items bearing either talker-preferred or talker-dispreferred colors. As the utterance began to unfold, the 5-year-olds anticipated that talkers would refer to talker-preferred objects...
December 7, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29219792/-unilateral-blindness-following-a-non-surgical-rhinoplasty-with-filler
#5
L W Schelke, M Fick, L J van Rijn, T Decates, P J Velthuis, F Niessen
BACKGROUND: A rare but known adverse event following a cosmetic filler treatment is unilateral blindness. In the Netherlands, this complication has not been reported in a patient before. CASE DESCRIPTION: A 26-year-old woman developed unilateral blindness after undergoing a cosmetic treatment of the dorsum nasi in which hyaluronic acid was used as filler. The blindness was caused by backflow of the filler via the ophthalmic artery into the carotid internal artery...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29218826/poly-lactic-acid-composites-based-on-graphene-oxide-particles-with-antibacterial-behavior-enhanced-by-electrical-stimulus-and-biocompatibility
#6
P Arriagada, H Palza, P Palma, M Flores, P Caviedes
Poly(lactic acid) (PLA) is a biodegradable and biocompatible polyester widely used in biomedical applications. Unfortunately, this biomaterial suffers from some shortcomings related with the absence of both bioactivity and antibacterial capacity. In this work, composites of PLA with either graphene oxide (GO) or thermally reduced graphene oxide (TrGO) were prepared by melt mixing to overcome these limitations. PLA composites with both GO and TrGO inhibited the attachment and proliferation of E. coli and S. aureus bacteria depending on the kind and amount of filler...
December 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29218476/google-trends-as-a-resource-for-informing-plastic-surgery-marketing-decisions
#7
Brittany Ward, Max Ward, Boris Paskhover
BACKGROUND: Celebrities have long influenced the medical decisions of the general population. By analyzing Google search data using Google Trends, we measured the impact of highly publicized plastic surgery-related events on the interest level of the general population in specific search terms. Additionally, we investigated seasonal and geographic trends around interest in rhinoplasties, which is information that physicians and small surgical centers can use to optimize marketing decisions...
December 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29218435/educational-review-measurement-of-gfr-in-special-populations
#8
Guido Filler, Misan Lee
IMPORTANCE: Changes in kidney function are typically followed by the sequential estimation of glomerular filtration rate (eGFR). Formulae for eGFR work well on a population basis, but there are well-known conditions where they do not work. OBJECTIVE: The purpose of this review is to summarize the existing literature on special populations in the pediatric age range and provide recommendations on how to estimate GFR in these populations. FINDINGS: The reliability of creatinine depends on muscle mass, while cystatin C (not widely available) is limited by inflammation and changes in protein catabolism...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29217312/long-term-stability-of-dental-adhesive-incorporated-by-boron-nitride-nanotubes
#9
Felipe Weidenbach Degrazia, Vicente Castelo Branco Leitune, Fernanda Visioli, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
OBJECTIVE: The aim of this study was to evaluate physicochemical properties, long-term microtensile bond strength and cytotoxicity of methacrylate-based adhesive containing boron nitride nanotubes (BNNTs) as fillers. METHODS: A dental adhesive was formulated using BisGMA/HEMA, 66/33wt% (control). Inorganic BNNT fillers were incorporated into the adhesive at different concentrations (0.05, 0.075, 0.1 and 0.15wt%). Analyses of degree of conversion (DC), polymerization rate [Rp...
December 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29217274/contact-wear-of-artificial-denture-teeth
#10
Verena Preis, Sebastian Hahnel, Michael Behr, Martin Rosentritt
PURPOSE: High wear resistance of denture teeth preserves good occlusal relationship and sufficient parafunctional stability. This in-vitro investigation aimed to determine and compare the wear performance of different artificial denture teeth. METHODS: Denture teeth of fifteen commercial products (n=8/group) were loaded in a pin-on-block design using steatite antagonists (d=3mm). Cyclic loading (50 N) was applied for 120,000 loadings (f=1.2Hz) with simultaneous thermal cycling (distilled water, 5°C/55°C, 2min/cycle)...
December 4, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29214209/the-impact-of-fillers-on-lineup-performance
#11
Stacy A Wetmore, Ryan M McAdoo, Scott D Gronlund, Jeffrey S Neuschatz
Filler siphoning theory posits that the presence of fillers (known innocents) in a lineup protects an innocent suspect from being chosen by siphoning choices away from that innocent suspect. This mechanism has been proposed as an explanation for why simultaneous lineups (viewing all lineup members at once) induces better performance than showups (one-person identification procedures). We implemented filler siphoning in a computational model (WITNESS, Clark, Applied Cognitive Psychology 17:629-654, 2003), and explored the impact of the number of fillers (lineup size) and filler quality on simultaneous and sequential lineups (viewing lineups members in sequence), and compared both to showups...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29214014/influence-of-perceived-difficulty-of-cases-on-student-osteopaths-diagnostic-reasoning-a-cross-sectional-study
#12
Aurelien L Noyer, Jorge E Esteves, Oliver P Thomson
Background: Diagnostic reasoning refers to the cognitive processes by which clinicians formulate diagnoses. Despite the implications for patient safety and professional identity, research on diagnostic reasoning in osteopathy remains largely theoretical. The aim of this study was to investigate the influence of perceived task difficulty on the diagnostic reasoning of students osteopaths. Methods: Using a single-blinded, cross sectional study design, sixteen final year pre-registration osteopathy students diagnosed two standardized cases under two context conditions (complex versus control)...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29208280/formulation-and-biological-actions-of-nano-bioglass-ceramic-particles-doped-with-calcarea-phosphorica-for-bone-tissue-engineering
#13
S Dinesh Kumar, K Mohamed Abudhahir, N Selvamurugan, S Vimalraj, R Murugesan, N Srinivasan, A Moorthi
The improvisation of the treatment procedures for treating the various kind of bone defects such as, bone or dental trauma and for diseases such as osteoporosis, osteomyelitis etc., need the suitable and promising biomaterials with resemblance of bone components. Bioactive glass ceramic (BGC) has recently acquired great attention as the most promising biomaterials; hence it has been widely applied as a filler material for bone tissue regeneration. Because it elicts specific biological responses after implantation in addition more potential in formation of strong interface with both hard and soft tissues by dissolution of calcium and phosphate ions...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207243/significantly-enhanced-dielectric-performances-and-high-thermal-conductivity-in-poly-vinylidene-fluoride-based-composites-enabled-by-sic-sio2-core-shell-whiskers-alignment
#14
Dalong He, Yao Wang, Silong Song, Song Liu, Yuan Deng
Design of composites with ordered fillers arrangement results in anisotropic performances with greatly enhanced properties along specific direction, which is a powerful tool to optimize physical properties of composites. Well aligned core-shell SiC@SiO2 whiskers in poly(vinylidene fluoride) (PVDF) matrix has been achieved via a modified spinning approach. Due to high aspect ratio of SiC whiskers, strong anisotropy and significant enhancement in dielectric constant were observed with permittivity 854 along parallel direction vs...
December 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29206446/design-of-complex-nanomaterials-for-energy-storage-past-success-and-future-opportunity
#15
Yayuan Liu, Guangmin Zhou, Kai Liu, Yi Cui
The development of next-generation lithium-based rechargeable batteries with high energy density, low cost, and improved safety is a great challenge with profound technological significance for portable electronics, electric vehicles, and grid-scale energy storage. Specifically, advanced lithium battery chemistries call for a paradigm shift to electrodes with high Li to host ratio based on a conversion or alloying mechanism, where the increased capacity is often accompanied by drastic volumetric changes, significant bond breaking, limited electronic/ionic conductivity, and unstable electrode/electrolyte interphase...
December 5, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29206140/surfactant-effects-on-structure-and-mechanical-properties-of-ultrahigh-molecular-weight-polyethylene-layered-silicate-composites
#16
Leonid A Nikiforov, Tatinana A Okhlopkova, Iullia V Kapitonova, Sardana A Sleptsova, Aitalina A Okhlopkova, Ee Le Shim, Jin-Ho Cho
In this study, the reinforcement of ultrahigh-molecular-weight polyethylene (UHMWPE) with biotite was investigated. The biotite filler was mechanically activated with different dry surfactants to improve its compatibility with UHMWPE and decrease agglomeration among biotite particles. Alkyldimethylbenzylammonium chloride (ADBAC) and cetyltrimethylammonium bromide (CTAB) were selected as cationic surfactants. The tensile strength of composites containing 1 wt % of CTAB-treated biotite was increased by 30% relative to those with untreated biotite, but was unchanged with ADBAC treatment of the same biotite content...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29202573/the-use-of-hyaluronic-acid-as-a-support-of-two-different-micronized-biomaterials-in-crestal-sinus-lift-procedures-a-report-on-two-case-studies-with-volume-comparison
#17
M A Lopez, M Casale, V Candotto, R Papalia, F Bressi, F Carinci
In the context of the trans crestal maxillary sinus lift, a wide variety of biomaterials have been used to fill the sub-antral space over the years. The materials that have a pasty consistency and are smooth and free from lumps are the most suitable to come into contact with the Schneiderian membrane which, if torn, cannot perform its graft containment function. In this study, a micronized heterologous bone in a collagen matrix of two different percentages was used in order to fill the maxillary sinus. Before using biomaterial as filler, a spray form of hyaluronic acid was used to disinfect the surgical site before and after the surgery, along with more consistent and pasty form of gel of hyaluronic acid being used in order to facilitate the detachment of the membrane...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202558/malar-region-rejuvenation-through-non-invasive-techniques-hyaluronic-acid-fillers-and-lipofilling
#18
M Pascali, D Quarato, T Marianetti, F Carinci
Contour enhancements of the midface make up a dominant aspect of aesthetic surgery. The goal of midface rejuvenation is to decrease the prominence of grooves and creases as well as to provide volume to atrophied tissue. There are various options, including autologous tissue grafts, allogenic tissue grafts and alloplastic materials. In turn, patients’ needs have led to an increasing trend of less invasive treatments. In the present study, 82 implants were used for midface augmentation in 41 patients (38 women, 3 men) between January 2014 and January 2016...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29199877/the-duration-of-hyaluronidase-and-optimal-timing-of-hyaluronic-acid-ha-filler-reinjection-after-hyaluronidase-injection
#19
H J Kim, S B Kwon, K U Whang, J S Lee, Y L Park, S Y Lee
BACKGROUND: Hyaluronidase injection is a commonly performed treatment for overcorrection or misplacement of hyaluronic acid (HA) filler. Many patients often wants the HA filler reinjection after the use of hyaluronidase, though the optimal timing of reinjection of HA filler still remains unknown. OBJECTIVES: To provide the optimal time interval between hyaluronidase injections and HA filler reinjections. METHODS: 6 Sprague-Dawley rats were injected with single monophasic HA filler...
February 16, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29196900/novel-poss-reinforced-chitosan-composite-membranes-for-guided-bone-tissue-regeneration
#20
Sedef Tamburaci, Funda Tihminlioglu
In this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively...
December 1, 2017: Journal of Materials Science. Materials in Medicine
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