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Xue Jin, Dong Yang, Yuqian Jiang, Pengfei Duan, Minghua Liu
Light irradiation was found to trigger the self-assembly of a cyanostilbene-conjugated dialkyl glutamide from nanobelts to nanotoroids, which emitted inverse circularly polarized luminescence.
May 1, 2018: Chemical Communications: Chem Comm
Erica Nathan, K Vijayashree, A Harikrishna, Makoto Takafuji, Hirokuni Jintoku, Hirotaka Ihara, N M Rao
Photosensitizers (PS) are used in photodynamic therapy to treat several cancers. The efficacy of photodynamic therapy (PDT) could be further improved by overcoming aggregation-dependent quenching of PS and by improving the biodistribution of the PS. In this work we attempted to overcome these issues by conjugating a PS with a lipid molecule and tested the liposomes prepared with this PS conjugated lipid for PDT. A novel lipid-porphyrin conjugate (1 : 1) was synthesized by attaching a PS, 5-(4-methoxycarbonylphenyl)-10,15,20-triphenyl-21 H,23 H-porphine, to the head group of a glutamide lipid...
November 30, 2016: Photochemical & Photobiological Sciences
Yunqiang Tang, Jinguo Sun, Bingzhu Yin
A Schiff base-type fluorescent probe (1) consist of 2-hydroxynaphthaldehyde and glutamide moieties has been designed and synthesized for detection Zn2+ and Al3+ . The probe shows pH dependent dual-selectivity for Zn2+ and Al3+ in Tris-HCl buffer, viz. that can selectively recognized Zn2+ at pH 7.4 and Al3+ at pH 6.0, respectively. From Job's plots and MS data, the stoichiometric ratios of the probe with Zn2+ and Al3+ appeared to be 1:1 and 2:1, respectively. The probe can detect as low as 5.5 × 10-8  M-1 Zn2+ and 1...
October 26, 2016: Analytica Chimica Acta
Xiufeng Wang, Fan Xie, Pengfei Duan, Minghua Liu
Supramolecular gelation provides an efficient way of fabricating functional soft materials with various nanostructures. Amphiphiles containing naphthyl group and dialkyl l-glutamide with a methylene spacer, 1NALG and 2NALG, have been designed and their self-assembly in various organic solvents were investigated. Both of these compounds formed organogels in organic solvents. In the case of the alcohol solvents, the initially formed organogel underwent gel-precipitate transformation, which process was monitored by the UV-vis, CD spectra, and SEM observation...
November 29, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Hao Li, Xian Li, Chao Zhang, Qiquan Sun, Wei Yi, Xuan Wang, Du Cheng, Shupeng Chen, Biling Liang, Xintao Shuai
A diblock copolymer of poly(ethylene glycol) (PEG) and poly(γ-benzyl L-glutamate) (PBLG), PEG-PBLG, was synthesized via the ring-opening polymerization of γ-benzyl L-glutamate N-carboxyanhydride (BLG-NCA) using allyl-PEG-NH2 as a macroinitiator. After deprotection of the benzyl groups, N,N-diisopropyl ethylenediamine (DIP) was conjugated to poly(L-glutamic acid) (PGA) blocks as side groups. The pendant DIP groups on the PGA blocks greatly enhance the pH-sensitivity of poly(ethylene glycol)-block-poly[N-(N',N'-diisopropylaminoethyl) glutamide] [PEG-PGA(DIP)] micelles, and a higher grafting percentage of DIP favors a faster acid-response...
June 2016: Journal of Biomedical Nanotechnology
Dong Yang, Yin Zhao, Kai Lv, Xiufeng Wang, Wei Zhang, Li Zhang, Minghua Liu
A general strategy to tune the achiral main chain polymers into helical nanoassemblies was proposed based on the co-gelation approach. As an example, two achiral main chain polymers, PCz8 and PSi8, were selected, and their co-assembly with an amphiphilic l- or d-glutamide gelator was investigated. Although the polymers could not form gels individually, they could form co-gels with the gelator and the resultant gels exhibited macroscopic supramolecular chirality, which could be confirmed by CD spectra and SEM observations...
January 28, 2016: Soft Matter
Abul K Mallik, Hongdeng Qiu, Yutaka Kuwahara, Makoto Takafuji, Hirotaka Ihara
A double β-alanylated L-glutamide-derived organic phase has been newly designed and synthesized in such a way that integrated H-bonding (interaction) sites make it very suitable for the separation of versatile analytes, including shape-constrained isomers, and nonpolar, polar and basic compounds. The β-alanine residues introduced into two long-chain alkyl group moieties provide ordered polar groups through H-bonding among the amide groups.
September 28, 2015: Chemical Communications: Chem Comm
Hiroki Noguchi, Tiraporn Charoenraks, Makoto Takafuji, Hirotaka Ihara
We have reported that self-assembling glutamide lipid-grafted porous silica particles show high selectivity towards polycyclic aromatic hydrocarbons (PAHs) and bio-molecules. This enhancement of molecular recognition is brought about by the formation of a highly ordered structure in the glutamide lipid through intermolecular hydrogen bonding. To utilise, for selective separations, the highly oriented structure of glutamide lipids on the silica surface, in this study, we synthesised four glutamide lipids with different substitution groups and studied the separation behaviours of the glutamide lipid-grafted porous silica particles as reversed phase high-performance liquid chromatography (RP-HPLC) stationary phases...
May 1, 2015: Journal of Chromatography. A
Li Zhang, Qingxian Jin, Kai Lv, Long Qin, Minghua Liu
Self-assembled chiral nanostructures such as nanofibers and nanotubes formed by a pyridylpyrazole-conjugated l-glutamide showed an enantioselective recognition toward a fluorescence labeled chiral amino acid.
March 11, 2015: Chemical Communications: Chem Comm
Kai Lv, Li Zhang, Wensheng Lu, Minghua Liu
Chiral nanostructure, such as the double helix of DNA and α-helix of protein, plays an important role in biochemistry and material sciences. In the organism system, the biological entities always exhibit homochirality and show preference toward one specific enantiomer. How the opposite enantiomers will affect the chirality of the supramolecular nanostructures and their interactions with the biological molecules remains an important issue. In this study, two gelators bearing amphiphilic l-glutamide and d- or l-pantolactone (abbreviated as DPLG and LPLG) were designed, and their self-assembly behavior and interactions with proteins were investigated...
2014: ACS Applied Materials & Interfaces
Xiufeng Wang, Minghua Liu
Although solvent is the major component of the gel, it still remains unclear how the solvent molecules take part in the formation of the gel nanostructures in many gels. In this study it was observed that the vicinal effect on gel formation as well as their nanostructures, that is, the vicinal solvent molecules to the gelator, determine the molecular packing and their subsequent structures and properties. A naphthylacryl-conjugated L-glutamide gelator was found to form organogels in various solvents and nanofiber structures...
August 4, 2014: Chemistry: a European Journal
Xiufeng Wang, Pengfei Duan, Minghua Liu
A series of new π-conjugated gelators that contain various aromatic rings (phenyl, naphthyl, 9-anthryl) and amphiphilic L-glutamide was designed, and their gel formation in organic solvents and self-assembled nanostructures was investigated. The gelators showed good gelation ability in various organic solvents that ranged from polar to nonpolar. Those gelator molecules with small rings such as phenyl and naphthyl self-assembled into nanotube structures in most organic solvents and showed strong blue emission...
March 2014: Chemistry, An Asian Journal
Xiufeng Wang, Pengfei Duan, Minghua Liu
Novel amphiphilic molecules composed of naphthylacryl and L-glutamide moieties (1-NA and 2-NA) have been designed and their organogel formation in various organic solvents as well as their self-assembled nanostructures have been investigated. Both compounds formed organogels in many organic solvents, ranging from nonpolar to polar, and self-assembled into essentially nanofiber structures, although some twist or belt structures could be observed in certain solvents. A gel of compound 2-NA in ethanol initially self-assembled into nanofibers and then these were transformed into a family of coaxial hollow toruloid-like (CHTL) nanostructures under irradiation, in which various toroids and disks of different sizes were stacked coaxially...
November 18, 2013: Chemistry: a European Journal
F Shao, X D Xu
BACKGROUND: To investigate the effect of microbiological and immunological enteral nutrition (MEIN composed by probiotics, L-Glutamide, deep-sea fish oil and Nutrison Fibre) on intestinal function and immune status in the patients with long-term use of antibiotics. PATIENTS AND METHODS: 56 severe apoplexy patients with pulmonary infectious complication were randomly divided into two groups: a microbiological and immunological enteral nutrition group (MEIN group, n=28) and an enteral nutrition group (EN group, n=28)...
September 2013: European Review for Medical and Pharmacological Sciences
Qingxian Jin, Li Zhang, Minghua Liu
The self-assembly of a low-molecular-weight organogelator into various hierarchical structures has been achieved for a pyridylpyrazole linked L-glutamide amphiphile in different solvents. Upon gel formation, supramolecular chirality was observed, which exhibited an obvious dependence on the polarity of the solvent. Positive supramolecular chirality was obtained in nonpolar solvents, whereas it was inverted into negative supramolecular chirality in polar solvents. Moreover, the gelator molecules self-assembled into a diverse array of nanostructures over a wide scale range, from nanofibers to nanotubes and microtubes, depending on the solvent polarity...
July 8, 2013: Chemistry: a European Journal
Wangen Miao, Li Zhang, Xiufeng Wang, Long Qin, Minghua Liu
Three metal complexes consisting of Li(+), Zn(2+), and Al(3+) and quinolinol-functionalized L-glutamides (HQLG), (abbreviated as LiHQLG, Zn(HQLG)2, and Al(HQLG)3) were found to form fluorescent metallogels in several organic solvents. In solution, these chiral complexes showed neither any CD signal in the chromophore region nor chiral recognition of the chiral species. However, upon gel formation, the supramolecular chirality emerged because of the self-assembled nanostructures, which provided an opportunity for the chiral recognition of enantiomeric ligands...
May 7, 2013: Langmuir: the ACS Journal of Surfaces and Colloids
Wangen Miao, Li Zhang, Xiufeng Wang, Hai Cao, Qingxian Jin, Minghua Liu
A dual-functional metallogel, which was based on the copper(II) complex of quinolinol-substituted L-glutamide, showed both redox-responsive and enantioselective properties; moreover, the metallogels collapsed into a sol after reduction and could be revived upon subsequent oxidation. The supramolecular chirality and morphology also reversible changed with the gel-sol transition. Furthermore, the metallogels showed new enantioselective recognition towards chiral aromatic amino acids. A new emission band in the blue-light region at around 393 nm appeared when the metallogels encountered L-aromatic amino acids, whereas no new emission band was observed for the corresponding D-aromatic amino acids...
February 25, 2013: Chemistry: a European Journal
Pengchong Xue, Ran Lu, Peng Zhang, Junhui Jia, Qiuxia Xu, Tierui Zhang, Makoto Takafuji, Hirotaka Ihara
A glutamide gelator, 1, was synthesized, and a weak emission enhancement was observed during its gelation. In addition, 1 could be an excellent scaffold for successfully embedding an energy acceptor, 2, into its aggregate to obtain highly efficient energy transfer. An amplification of the emission enhancement was observed in the two-component gels compared to that of the neat gel of 1 during gel formation. For example, 1 induced only a 2.5-fold increase in emission intensity, whereas a 23-fold enhanced emission could be observed in the two-component gel with only 1...
January 8, 2013: Langmuir: the ACS Journal of Surfaces and Colloids
Abul K Mallik, Hongdeng Qiu, Tsuyoshi Sawada, Makoto Takafuji, Hirotaka Ihara
The relationship between molecular gel-forming compound-based double-alkylated L-glutamide-derived functional group-integrated organic phase (Sil-FIP) structure and chromatographic performance is investigated and compared with widely used alkyl phases (C(30), polymeric and monomeric C(18)) as references. The functional group-integrated molecular gel on silica is chemically designed newly in a way that the weak interaction sites are integrated with high orientation and high selectivity can be realized by multiple interactions with the solutes...
August 7, 2012: Analytical Chemistry
Xiufeng Wang, Pengfei Duan, Minghua Liu
A newly designed terephthalic acid substituted amphiphilic L-glutamide was found to form organogels in DMSO and a broad range of metal ions, from simple Na(+), Li(+) to Cu(2+), Ni(2+), Eu(3+) and Tb(3+), could turn the self-assembled nanostructure into a uniform helical twist.
August 4, 2012: Chemical Communications: Chem Comm
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