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https://www.readbyqxmd.com/read/28549358/-complication-analysis-in-lisfranc-fracture-dislocation
#1
R J García-Renedo, A Carranza-Bencano, R Leal-Gómez, F Cámara-Arrigunaga
OBJECTIVE: To value the complications and sequels for patients with Lisfrancs fracture-luxation (FLL). MATERIAL AND METHODS: A transverse ambispective study of cohorts was realized of 83 patients by diagnosis of Lisfrancs fracture-luxation. There was in use a protocol of withdrawal of information with variables related to the injury, clinical, therapeutic parameters, complications and scales of clinical valuation. RESULTS: 66 patients (79...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28529490/microgravity-induced-transcriptome-adaptation-in-mouse-paraspinal-longissimus-dorsi-muscle-highlights-insulin-resistance-linked-genes
#2
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate longissimus dorsi adaptation to microgravity at both morphological and global gene expression level. C57BL/N6 male mice were flown aboard the BION-M1 biosatellite for 30 days (BF) or housed in a replicate flight habitat on ground (BG)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28512039/fluorescein-guided-surgery-for-high-grade-glioma-resection-an-intraoperative-contrast-enhancer
#3
Giuseppe Catapano, Francesco Giovanni Sgulò, Vincenzo Seneca, Giovanni Lepore, Laura Columbano, Giuseppe di Nuzzo
BACKGROUND: Fluorescein sodium salt is widely used in medicine as fluorescein isothiocyanate and commonly named fluorescein (FL). This fluorophore has been used as a fluorescent tracer for many applications, especially in ophthalmic surgery. The initial use in neuro-oncologic field occurred in 1948 in order to control tumor resection margins. After a transient disuse, it has recently had a second spring with the development of dedicated filters for operating microscope, although it is still under evaluation in clinical use...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28507191/lowering-metabolic-rate-mitigates-muscle-atrophy-in-western-fence-lizards
#4
J Balaban, E Azizi
Extended periods of skeletal muscle disuse can cause a significant loss of contractile proteins, which compromises the ability to generate force, mechanical work or power, thus compromising locomotor performance. Several hibernating organisms can resist muscle atrophy despite months of inactivity. This resistance has been attributed to a reduction in body temperature and metabolic rate and activation of physiological pathways that counteract pathways of protein degradation. However, in these systems such strategies are not mutually exclusive and the effects of these mechanisms can be difficult to separate...
May 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28499991/an-interactive-simulator-for-imposing-virtual-musculoskeletal-dynamics
#5
Christopher Hasson
OBJECTIVE: Disease processes are often marked by both neural and muscular changes that alter movement control and execution, but these adaptations are difficult to tease apart because they occur simultaneously. This is addressed by swapping an individual's limb dynamics with a neurally-controlled facsimile using an interactive musculoskeletal simulator (IMS) that allows controlled modifications of musculoskeletal dynamics. This paper details the design and operation of the IMS, quantifies and describes human adaptation to the IMS, and determines whether the IMS allows users to move naturally, a prerequisite for manipulation experiments...
May 10, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28497057/electrical-stimulation-of-denervated-rat-skeletal-muscle-retards-capillary-and-muscle-loss-in-early-stages-of-disuse-atrophy
#6
Kouki Nakagawa, Hiroyuki Tamaki, Keishi Hayao, Kengo Yotani, Futoshi Ogita, Noriaki Yamamoto, Hideaki Onishi
The purpose of the present study is to investigate the effects of low-frequency electrical muscle stimulation (ES) on the decrease in muscle mass, fiber size, capillary supply, and matrix metalloproteinase (MMP) immunoreactivity in the early stages of denervation-induced limb disuse. Direct ES was performed on the tibialis anterior muscle following denervation in seven-week-old male rats. The rats were divided into the following groups: control (CON), denervation (DN), and denervation with direct ES (DN + ES)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28459127/neuromuscular-deconditioning-with-disuse-should-we-live-more-on-our-nerves
#7
Marco V Narici
No abstract text is available yet for this article.
April 29, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28452077/structure-and-function-of-human-muscle-fibres-and-muscle-proteome-in-physically-active-older-men
#8
Lorenza Brocca, Jamie S McPhee, Emanuela Longa, Monica Canepari, Olivier Seynnes, Giuseppe De Vito, Maria Antonietta Pellegrino, Marco Narici, Roberto Bottinelli
Contradictory results have been reported on the impact of ageing on structure and functions of skeletal muscle fibres likely due to complex interplay between ageing and other phenomena such as disuse and diseases. Here we recruited healthy, physically and socially active young (YO) and elderly (EL) men in order to study aging per se without the confounding effects of impaired physical function. In vivo analyses of quadriceps and in vitro analyses of vastus lateralis muscle biopsies were performed. In EL subjects, our results show that: (i) quadriceps volume, maximum voluntary torque (MVC), and patellar tendon force (Ft) were significantly lower; (ii) muscle fibres went through significant atrophy and impairment of specific force (Po/CSA) and unloaded shortening velocity (Vo); (iii) myosin/actin ratio and myosin content in individual muscle fibres were not altered; (iv) muscle proteome went through quantitative adaptations, namely an up-regulation of the content of several groups of proteins among which myofibrillar proteins and antioxidant defence systems; (v) muscle proteome went through qualitative adaptations, namely phosphorylation of several proteins, including Myosin Light Chain-2 slow and Troponin T and carbonylation of Myosin Heavy Chains...
April 27, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28447380/lncrna-h19-modulates-wnt-%C3%AE-catenin-signaling-by-targeting-dkk4-in-hindlimb-unloaded-rat
#9
Bing Li, Jun Liu, Jie Zhao, Jian-Xiong Ma, Hao-Bo Jia, Yang Zhang, Guo-Sheng Xing, Xin-Long Ma
OBJECTIVE: To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS: Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU)...
April 26, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28424626/a-rat-immobilization-model-based-on-cage-volume-reduction-a-physiological-model-for-bed-rest
#10
Enrica Marmonti, Sílvia Busquets, Míriam Toledo, Marina Ricci, Marc Beltrà, Victòria Gudiño, Francesc Oliva, José M López-Pedrosa, Manuel Manzano, Ricardo Rueda, Francisco J López-Soriano, Josep M Argilés
Bed rest has been an established treatment in the past prescribed for critically illness or convalescing patients, in order to preserve their body metabolic resource, to prevent serious complications and to support their rapid path to recovery. However, it has been reported that prolonged bed rest can have detrimental consequences that may delay or prevent the recovery from clinical illness. In order to study disuse-induced changes in muscle and bone, as observed during prolonged bed rest in humans, an innovative new model of muscle disuse for rodents is presented...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28413464/anti-climacterium-effects-of-pomegranate-concentrated-solutions-in-ovariectomized-ddy-mice
#11
Su Jin Kang, Beom Rak Choi, Seung Hee Kim, Hae Yeon Yi, Hye Rim Park, Chang Hyun Song, Sae Kwang Ku, Young Joon Lee
In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28407141/sensory-deprivation-triggers-synaptic-and-intrinsic-plasticity-in-the-hippocampus
#12
Hila Milshtein-Parush, Samuel Frere, Limor Regev, Coren Lahav, Amit Benbenishty, Shamgar Ben-Eliyahu, Inbal Goshen, Inna Slutsky
Hippocampus, a temporal lobe structure involved in learning and memory, receives information from all sensory modalities. Despite extensive research on the role of sensory experience in cortical map plasticity, little is known about whether and how sensory experience regulates functioning of the hippocampal circuits. Here, we show that 9 ± 2 days of whisker deprivation during early mouse development depresses activity of CA3 pyramidal neurons by several principal mechanisms: decrease in release probability, increase in the fraction of silent synapses, and reduction in intrinsic excitability...
April 12, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28402337/bone-marrow-adipose-tissue-deficiency-increases-disuse-induced-bone-loss-in-male-mice
#13
Jessica A Keune, Carmen P Wong, Adam J Branscum, Urszula T Iwaniec, Russell T Turner
Bone marrow adipose tissue (MAT) is negatively associated with bone mass. Since osteoblasts and adipocytes are derived from the same precursor cells, adipocyte differentiation may occur at the expense of osteoblast differentiation. We used MAT-deficient Kit(W/W-v) (MAT-) mice to determine if absence of MAT reduced bone loss in hindlimb-unloaded (HU) mice. Male MAT- and wild-type (WT) mice were randomly assigned to a baseline, control or HU group (n = 10 mice/group) within each genotype and HU groups unloaded for 2 weeks...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388378/protein-turnover-and-metabolism-in-the-elderly-intensive-care-unit-patient
#14
Stuart M Phillips, Roland N Dickerson, Frederick A Moore, Douglas Paddon-Jones, Peter J M Weijs
Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years) patients in the ICU may be particularly rapid due to a perfect storm of increased catabolic factors, including systemic inflammation, disuse, protein malnutrition, and reduced anabolic stimuli. This loss of muscle mass has marked consequences...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28387014/weak-by-the-machines-muscle-motor-protein-dysfunction-a-side-effect-of-intensive-care-unit-treatment
#15
REVIEW
O Friedrich, S Diermeier, L Larsson
Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU-acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome pathway plays an important role, apart from recently identified novel mechanisms affecting non-lysosomal protein degradation or autophagy...
April 7, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28373598/raccoon-dog-model-shows-preservation-of-bone-during-prolonged-catabolism-and-reduced-physical-activity
#16
Anne-Mari J Mustonen, Mikko A J Finnilä, Katri S Puukka, Timo J Jämsä, Simo Saarakkala, Juha K Tuukkanen, T Petteri Nieminen
The raccoon dog (Nyctereutes procyonoides) is a promising animal model capable of preventing disuse-induced osteoporosis. Previous data suggest that this species resembles bears in the preservation of bone mass and biomechanical properties during prolonged passivity and catabolism. This longitudinal study examined the osteological properties of tibiae in farm-bred raccoon dogs that were either fed or fasted (n=6/group) for a 10-week period. Peripheral quantitative computed tomography was utilized and plasma markers of bone turnover measured before fasting and at 9 weeks followed by mechanical testing (three-point bending), micro-computed tomography and Fourier transform infrared imaging at 10 weeks...
April 3, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28372352/avoidable-burden-of-risk-factors-for-serious-road-traffic-crashes-in-iran-a-modeling-study
#17
Fatemeh Khosravi Shadmani, Kamyar Mansori, Manoochehr Karami, Farid Zayeri, Reza Khosravi Shadman, Shiva Mansouri Hanis, Hamid Soori
OBJECTIVES: The aim of this study was to model the avoidable burden of the risk factors of road traffic crashes in Iran and to prioritize interventions to reduce that burden. METHODS: The prevalence and the effect size of the risk factors were obtained from data documented by the traffic police of Iran in 2013. The effect size was estimated using an ordinal regression model. The potential impact fraction index was applied to calculate the avoidable burden in order to prioritize interventions...
March 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28365811/disuse-osteopenia-induced-by-botulinum-toxin-is-similar-in-skeletally-mature-young-and-aged-female-c57bl-6j-mice
#18
Jens Bay Vegger, Annemarie Brüel, Mikkel Bo Brent, Jesper Skovhus Thomsen
Osteopenia and osteoporosis predominately occur in the fully grown skeleton. However, it is unknown whether disuse osteopenia in skeletally mature, but growing, mice resembles that of fully grown mice. Twenty-four 16-week-old (young) and eighteen 44-week-old (aged) female C57BL/6J mice were investigated. Twelve young and nine aged mice were injected with botulinum toxin in one hind limb; the remaining mice served as controls. The mice were euthanized after 3 weeks of disuse. The femora were scanned by micro-computed tomography (µCT) and bone strength was determined by mechanically testing the femoral mid-diaphysis and neck...
April 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28363114/mechanical-mandible-competence-in-rats-with-nutritional-growth-retardation
#19
Christian Esteban Lezón, Patricia Mabel Pintos, Clarisa Bozzini, Alan Agüero Romero, Patricia Casavalle, Silvia María Friedman, Patricia Mónica Boyer
OBJECTIVE: In order to provide a better understanding of the sympathetic nervous system as a negative regulator of bone status, the aim of the study was to establish the biomechanical mandible response to different doses of a β-adrenergic antagonist such as propranolol (P) in a stress-induced food restriction model of growth retardation. METHODS: Rats were assigned to eight groups: Control (C), C+P3.5 (CP3.5), C+P7 (CP7), C+P14 (CP14), NGR, NGR+P3.5 (NGRP3.5), NGR+P7 (NGRP7) and NGR+P14 (NGRP14)...
March 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28342371/contrast-enhancement-with-uranyl-acetate-allows-quantitative-analysis-of-the-articular-cartilage-by-microct-application-to-mandibular-condyles-in-the-btx-rat-model-of-disuse
#20
Jean-Daniel Kün-Darbois, Florence Manero, Louis Rony, Daniel Chappard
Microcomputed tomography (microCT) is well adapted to quantitative analysis of calcified tissues but soft tissues (such as cartilage) are radiolucent and need a contrast enhancement procedure for microCT. We developed a "staining" method allowing microCT imaging of articular cartilage using uranyl acetate (UA). The method was used to see whether adult rats with a botulinum toxin (BTX) injection in masticatory muscles present a change at the condylar cartilage of the mandible in association with a localized trabecular bone loss...
March 21, 2017: Micron: the International Research and Review Journal for Microscopy
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