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https://www.readbyqxmd.com/read/28228482/physical-activity-aging-and-physiological-function
#1
REVIEW
Stephen D R Harridge, Norman R Lazarus
Human evolution suggests that the default position for health is to be physically active. Inactivity, by contrast, has serious negative effects on health across the lifespan. Therefore, only in physically active people can the inherent aging process proceed unaffected by disuse complications. In such individuals, although the relationship between age and physiological function remains complex, function is generally superior with health, well being, and the aging process optimized.
March 2017: Physiology
https://www.readbyqxmd.com/read/28220759/musculoskeletal-model-based-control-interface-mimics-physiologic-hand-dynamics-during-path-tracing-task
#2
Dustin Lee Crouch, Helen Huang
OBJECTIVE: We investigated the feasibility of a novel, customizable, simplified EMG-driven musculoskeletal model for estimating coordinated hand and wrist motions during a real-time path tracing task. APPROACH: A two-degree-of-freedom (DOF) computational musculoskeletal model was implemented for real-time EMG-driven control of a stick figure hand displayed on a computer screen. After 5 to 10 minutes of undirected practice, subjects were given 3 attempts to trace 10 straight paths, one at a time, with the fingertip of the virtual hand...
February 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28215635/mechanical-stimulation-promote-the-osteogenic-differentiation-of-bone-marrow-stromal-cells-through-epigenetic-regulation-of-sonic-hedgehog
#3
Chuandong Wang, Shengzhou Shan, Chenglong Wang, Jing Wang, Jiao Li, Guoli Hu, Kerong Dai, Qingfeng Li, Xiaoling Zhang
Mechanical unloading leads to bone loss and disuse osteoporosis partly due to impaired osteoblastogenesis of bone marrow stromal cells (BMSCs). However, the underlying molecular mechanisms of this phenomenon are not fully understood. In this study, we demonstrated that cyclic mechanical stretch (CMS) promotes osteoblastogenesis of BMSCs both in vivo and in vitro. Besides, we found that Hedgehog (Hh) signaling pathway was activated in this process. Inhibition of which by either knockdown of Sonic hedgehog (Shh) or treating BMSCs with Hh inhibitors attenuated the osteogenic effect of CMS on BMSCs, suggesting that Hh signaling pathway acts as an endogenous mediator of mechanical stimuli on BMSCs...
February 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28213864/electrical-stimulation-of-denervated-rat-skeletal-muscle-ameliorates-bone-fragility-and-muscle-loss-in-early-stage-disuse-musculoskeletal-atrophy
#4
Hiroyuki Tamaki, Kengo Yotani, Futoshi Ogita, Keishi Hayao, Kouki Nakagawa, Kazuhiro Sugawara, Hikari Kirimoto, Hideaki Onishi, Norikatsu Kasuga, Noriaki Yamamoto
We tested whether daily muscle electrical stimulation (ES) can ameliorate the decrease in cortical bone strength as well as muscle and bone geometric and material properties in the early stages of disuse musculoskeletal atrophy. 7-week-old male F344 rats were randomly divided into three groups: age-matched control group (Cont); a sciatic denervation group (DN); and a DN + direct electrical stimulation group (DN + ES). Denervated tibialis anterior (TA) muscle in the DN + ES group received ES with 16 mA at 10 Hz for 30 min/day, 6 days/week...
February 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28213301/mental-retirement-and-health-selection-analyses-from-the-u-s-health-and-retirement-study
#5
Sean A P Clouston, Nicole Denier
BACKGROUND: Research has recently suggested that retirement may decrease cognitive engagement, resulting in cognitive aging. Few studies have systematically documented whether or how selectivity into retirement shapes the relationship between retirement and cognitive aging. METHODS: We draw on data from the Health and Retirement Study (1998-2012) to examine the relationship between cognition and retirement for 18,575 labor force participants. Longitudinal regression discontinuity modeling was used to examine performance and decline in episodic memory...
January 22, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28203255/the-influencing-factors-on-procalcitonin-values-in-newborns-with-noninfectious-conditions-during-the-first-week-of-life
#6
Jueseong Lee, Yong Hyeon Bang, Eun Hee Lee, Byung Min Choi, Young Sook Hong
PURPOSE: Although procalcitonin (PCT) level is useful for the diagnosis of neonatal sepsis, PCT reliability is inconsistent because of the varied conditions encountered in neonatal intensive care units. This study aimed to investigate PCT levels and factors influencing increased PCT levelin newborns without bacterial infection during the first week of life. METHODS: In newborns hospitalized between March 2013 and October 2015, PCT levels were measured on the first, third, and seventh days after birth...
January 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28194277/risk-factors-and-prognosis-of-pain-events-during-mechanical-ventilation-a-retrospective-study
#7
Ayahiro Yamashita, Masaki Yamasaki, Hiroki Matsuyama, Fumimasa Amaya
BACKGROUND: Pain assessment is highly recommended in patients receiving mechanical ventilation. However, pain intensity and its impact on outcomes in these patients remain obscure. We collected the results of routine pain assessments, utilizing the behavioral pain scale (BPS), from 151 patients receiving mechanical ventilation. Risk factors associated with a pain event, defined as BPS of >5, and its impact on patient outcomes were investigated. METHODS: A total of 151 consecutive adult patients receiving mechanical ventilation for more than 24 h in a single 10-bed ICU were enrolled in this study...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28184997/molecular-characterization-of-myostatin-from-the-skeletal-muscle-of-the-african-lungfish-protopterus-annectens-and-changes-in-its-mrna-and-protein-expression-levels-during-three-phases-of-aestivation
#8
Jasmine L Y Ong, You R Chng, Biyun Ching, Xiu L Chen, Kum C Hiong, Wai P Wong, Shit F Chew, Yuen K Ip
African lungfishes can aestivate and remain torpid without food and water for years, but disuse muscle atrophy is not prominent during aestivation. This study aimed to clone myostatin (mstn/Mstn), a factor associated with disuse muscle atrophy in mammals, from the skeletal muscle of the African lungfish Protopterus annectens, and to determine its mRNA expression level and protein abundance therein during the induction, maintenance, and arousal phases of aestivation. The complete coding cDNA sequence of mstn comprised 1128 bp, encoding for 376 amino acids with an estimated molecular mass of 42...
February 9, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28177712/investigating-human-skeletal-muscle-physiology-with-unilateral-exercise-models-when-one-limb-is-more-powerful-than-two
#9
Martin J MacInnis, Chris McGlory, Martin J Gibala, Stuart M Phillips
Direct sampling of human skeletal muscle using the needle biopsy technique can facilitate insight into the biochemical and histological responses resulting from changes in exercise or feeding. However, the muscle biopsy procedure is invasive, and analyses are often expensive, which places pragmatic restraints on sample sizes. The unilateral exercise model can serve to increase statistical power and reduce the time and cost of a study. With this approach, two limbs of a participant are randomized to one of two treatments that can be applied almost concurrently or sequentially depending on the nature of the intervention...
January 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28175999/dietary-proteins-and-amino-acids-in-the-control-of-the-muscle-mass-during-immobilization-and-aging-role-of-the-mps-response
#10
REVIEW
Jason M Cholewa, Dominique Dardevet, Fernanda Lima-Soares, Kassiana de Araújo Pessôa, Paulo Henrique Oliveira, João Ricardo Dos Santos Pinho, Humberto Nicastro, Zhi Xia, Christian Emmanuel Torres Cabido, Nelo Eidy Zanchi
Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate muscle loss during immobilization and aging via the stimulation of muscle protein synthesis (MPS). An EAA's anabolic threshold, capable to maximize the stimulation of MPS has been hypothesized, but during certain conditions associated with muscle loss, this anabolic threshold seems to increase which reduces the efficacy of dietary EAAs to stimulate MPS. Preliminary studies have demonstrated that acute ingestion of dietary proteins/EAA (with a sufficient amount of leucine) was capable to restore the postprandial MPS during bed rest, immobilization or aging; however, whether these improvements translate into chronic increases (or attenuates loss) of muscle mass is equivocal...
February 7, 2017: Amino Acids
https://www.readbyqxmd.com/read/28160025/hypodynamia-alters-bone-quality-and-trabecular-microarchitecture
#11
Eric Aguado, Guillaume Mabilleau, Eric Goyenvalle, Daniel Chappard
Disuse induces a rapid bone loss in humans and animals; hypodynamia/sedentarity is now recognized as a risk factor for osteoporosis. Hypodynamia also decreases bone mass but its effects are largely unknown and only few animal models have been described. Hypodynamic chicken is recognized as a suitable model of bone loss but the effects on the quality have not been fully explored. We have used ten chickens bred in a large enclosure (FREE group); ten others were confined in small cages with little space to move around (HYPO group)...
February 3, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28156456/prevalence-of-myofascial-pain-syndrome-in-patients-with-incurable-cancer
#12
Junya Kinkawa, Aya Watanabe, Chie Watanabe, Tsukuru Chiba, Naoki Shimada, Keisuke Ariyoshi, Masanori Nojima, Satoru Iwase, Arinobu Tojo
: 97 Background: Myofascial pain syndrome (MPS) is a condition that involves skeletal muscles. It is caused by overload or disuse of muscles and is characterized by extreme tenderness in the muscles with taut bands. Treatment for MSP is different from that for cancer-related pain. Cancer patients have many factors that cause restriction of body movement and posture. Although cancer patients appear to demonstrate risk factors for MPS, its prevalence has not been reported in patients with incurable cancer...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28132706/performance-of-post-retained-single-crowns-a-systematic-review-of-related-risk-factors
#13
REVIEW
Rafael Sarkis-Onofre, Dean Fergusson, Maximiliano Sérgio Cenci, David Moher, Tatiana Pereira-Cenci
INTRODUCTION: Numerous factors may influence the survival/success of post-retained restorations of endodontically treated teeth (ETT). The aim of this review was to assess the influence of the number of remaining coronal walls, the use or disuse of posts, and their type on the clinical performance of these restorations. METHODS: Randomized controlled trials and controlled clinical trials for ETT restored with a combination of post/crown or no post/crown were searched for in MEDLINE, Embase, and the Cochrane Library...
February 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28129234/inflammation-relates-to-resistance-training-induced-hypertrophy-in-elderly-patients
#14
Kristoffer Larsen Norheim, Christopher Kjaer Cullum, Jesper Loevind Andersen, Michael Kjaer, Anders Karlsen
PURPOSE: Aging is associated with a gradual loss of muscle mass, which some have suggested to be accelerated by short periods of muscle disuse due to medical illness. We investigated the effect of hospitalization on skeletal muscle mass in acutely ill geriatric patients with focus on the relationship between systemic inflammatory marker C-reactive protein (CRP) and changes in muscle mass, as well as the influence of resistance training upon muscle mass. METHOD: Unilateral leg press resistance exercise was conducted daily during the hospital period...
January 26, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28096431/activation-of-respiratory-muscles-does-not-occur-during-cold-submergence-in-bullfrogs-lithobates-catesbeianus
#15
Joseph M Santin, Lynn K Hartzler
Semiaquatic frogs may not breathe air for several months because they overwinter in ice-covered ponds. In contrast to many vertebrates that experience decreased motor performance after inactivity, respiratory motor function in bullfrogs, Lithobates catesbeianus, remains functional following cold-submergence. Unlike mammalian hibernators with unloaded limb muscles and inactive locomotor systems, respiratory mechanics of frogs counterintuitively allow for ventilatory maneuvers when submerged. Thus we hypothesized that bullfrogs generate respiratory motor patterns during cold-submergence to avoid disuse and preserve motor performance...
January 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28096335/myofibril-breakdown-during-atrophy-is-a-delayed-response-requiring-the-transcription-factor-pax4-and-desmin-depolymerization
#16
Alexandra Volodin, Idit Kosti, Alfred Lewis Goldberg, Shenhav Cohen
A hallmark of muscle atrophy is the excessive degradation of myofibrillar proteins primarily by the ubiquitin proteasome system. In mice, during the rapid muscle atrophy induced by fasting, the desmin cytoskeleton and the attached Z-band-bound thin filaments are degraded after ubiquitination by the ubiquitin ligase tripartite motif-containing protein 32 (Trim32). To study the order of events leading to myofibril destruction, we investigated the slower atrophy induced by denervation (disuse). We show that myofibril breakdown is a two-phase process involving the initial disassembly of desmin filaments by Trim32, which leads to the later myofibril breakdown by enzymes, whose expression is increased by the paired box 4 (PAX4) transcription factor...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28076365/gene-expression-profiling-in-slow-type-calf-soleus-muscle-of-30-days-space-flown-mice
#17
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity exposure as well as chronic disuse are two main causes of skeletal muscle atrophy in animals and humans. The antigravity calf soleus is a reference postural muscle to investigate the mechanism of disuse-induced maladaptation and plasticity of human and rodent (rats or mice) skeletal musculature. Here, we report microgravity-induced global gene expression changes in space-flown mouse skeletal muscle and the identification of yet unknown disuse susceptible transcripts found in soleus (a mainly slow phenotype) but not in extensor digitorum longus (a mainly fast phenotype dorsiflexor as functional counterpart to soleus)...
2017: PloS One
https://www.readbyqxmd.com/read/28056188/tetramethylpyrazine-ameliorated-disuse-induced-gastrocnemius-muscle-atrophy-in-hindlimb-unloading-rats-through-suppression-of-ca-2-ros-mediated-apoptosis
#18
Nai-Fei Hu, Hui Chang, Bei Du, Quan-Wang Zhang, Yasir Arfat, Kai Dang, Yun-Fang Gao
The purpose of this study was to examine the possible mechanism underlying the protective effect of tetramethylpyrazine (TMP) against disuse-induced muscle atrophy. Sprague-Dawley rats were randomly assigned to receive 14 days of hindlimb unloading (HLU, a model of disuse atrophy) or cage controls. The rats were given TMP (60 mg/kg body mass) or vehicle (water) by gavage. Compared with vehicle treatment, TMP significantly attenuated the loss of gastrocnemius muscle mass (-33.56%, P < 0.01), the decrease of cross-sectional area of slow fiber (-10...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28054322/creatine-loading-does-not-preserve-muscle-mass-or-strength-during-leg-immobilization-in-healthy-young-males-a-randomized-controlled-trial
#19
Evelien M P Backx, Roland Hangelbroek, Tim Snijders, Marie-Louise Verscheijden, Lex B Verdijk, Lisette C P G M de Groot, Luc J C van Loon
BACKGROUND: A short period of leg immobilization leads to rapid loss of muscle mass and strength. Creatine supplementation has been shown to increase lean body mass in active individuals and can be used to augment gains in muscle mass and strength during prolonged resistance-type exercise training. OBJECTIVE: Our objective was to investigate whether creatine loading can attenuate the loss of muscle mass and strength during short-term leg immobilization. METHODS: Healthy young men (n = 30; aged 23 ± 1 years; body mass index [BMI] 23...
January 5, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28039408/nrf2-deficiency-does-not-affect-denervation-induced-alterations-in-mitochondrial-fission-and-fusion-proteins-in-skeletal-muscle
#20
Yu Kitaoka, Kohei Takeda, Yuki Tamura, Shin Fujimaki, Tohru Takemasa, Hideo Hatta
Oxidative stress-induced mitochondrial dysfunction is associated with age-related and disuse-induced skeletal muscle atrophy. However, the role of nuclear factor erythroid 2-related factor 2 (Nrf2) during muscle fiber atrophy remains to be elucidated. In this study, we examined whether deficiency of Nrf2, a master regulator of antioxidant transcription, promotes denervation-induced mitochondrial fragmentation and muscle atrophy. We found that the expression of Nrf2 and its target antioxidant genes was upregulated at 2 weeks after denervation in wild-type (WT) mice...
December 2016: Physiological Reports
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