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Botulinum toxin a

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https://www.readbyqxmd.com/read/28731959/efficacy-of-intra-articular-botulinum-toxin-in-osteo-articular-joint-pain-a-meta-analysis-of-randomized-controlled-trials
#1
Mathilde Courseau, Pascale Vergne Salle, Danièle Ranoux, Anais de Pouilly Lachatre
OBJECTIVE: To evaluate the efficacy of intra-articular injections of botulinum toxin A (BT-A) into the painful joint diseases through a systematic review of the literature and a meta-analysis of controlled randomized trials. Indeed, intra articular therapies (corticosteroids, hyaluronic acid) have limited efficacy and run a risk of toxicity in patients with joint pain. New therapeutic options are needed to treat painful osteo-articular disease. METHODS: We searched via Pubmed, ACR and EULAR congresses and grey literature for the studies reported until June 2016 and addressing the issue of BT intra articular injections in patients with refractory joint pain...
July 20, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28731141/botulinum-toxin-a-improves-adipose-tissue-engraftment-by-promoting-cell-proliferation-adipogenesis-and-angiogenesis
#2
Qi Tang, Chang Chen, Xiaqi Wang, Wei Li, Yan Zhang, Muyao Wang, Wei Jing, Hang Wang, Weihua Guo, Weidong Tian
Adipose tissue engraftment has become a well-established therapy in plastic and reconstructive surgery used to restore age-related or injury-related soft tissue loss. However, the unpredictable absorption rates limit its further application. Some clinicians have noted that more optimal aesthetic results are achieved when botulinum toxin A (BoNTA) is applied prior to adipose tissue grafting. In the present study, we transplanted allogeneic adipose tissue treated with or without BoNTA in SD rats in vivo. We subsequently evaluated the survival rate (weight, volume, apoptosis and cellular integrity) and revascularization of the adipose tissue...
July 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28729254/finished-whole-genome-sequences-of-clostridium-butyricum-toxin-subtype-e4-and-clostridium-baratii-toxin-subtype-f7-strains
#3
Jessica L Halpin, Karen Hill, Shannon L Johnson, David Carlton Bruce, T Brian Shirey, Janet K Dykes, Carolina Lúquez
Clostridium butyricum and Clostridium baratii species have been known to produce botulinum toxin types E and F, respectively, which can cause botulism, a rare but serious neuroparalytic disease. Here, we present finished genome sequences for two of these clinically relevant strains.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28727388/lysozyme-gene-treatment-in-testosterone-induced-benign-prostate-hyperplasia-rat-model-and-comparasion-of-its-effectiveness-with-botulinum-toxin-injection
#4
Osman Ergün, Pinar Aslan Koşar, İbrahim Onaran, Hakan Darici, Alim Koşar
OBJECTIVES: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model. MATERIALS AND METHODS: 40 male Wistar rats were randomized into four Groups. Group-1: Control, Group-2: Testosterone replacement, Group-3: Testosterone+botulinum neurotoxin type A, Group-4: Testosterone+plazmid DNA/liposome complex. RESULTS: Estimated prostate volume of the testosterone injected Groups were higher than the control (p <0...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726719/sima-cells-for-a-serotype-specific-and-sensitive-cell-based-neutralization-test-for-botulinum-toxin-a-and-e
#5
Nicola Bak, Shalini Rajagopal, Paul Stickings, Dorothea Sesardic
Botulinum toxins (BoNTs), of which there are seven serotypes, are among the most potent neurotoxins, with serotypes A, B and E causing human botulism. Antitoxins form the first line of treatment for botulism, and functional, highly sensitive in vitro methods for toxin neutralization are needed to replace the current in vivo methods used for determination of antitoxin potency. In this preliminary proof of concept study, we report the development of a neutralization test using the neuroblastoma SiMa cell line...
July 20, 2017: Toxins
https://www.readbyqxmd.com/read/28726023/benefits-and-risks-of-non-approved-injection-regimens-for-botulinum-toxins-in-spasticity
#6
Andrea Santamato, Francesco Panza
Spasticity with muscle paresis and loss of dexterity is a common feature of upper motor neuron syndrome due to injuries or the pyramidal tract in several neurological conditions. Botulinum toxin type A has been considered the gold standard treatment for spasticity and movement disorders, with efficacy, reversibility, and low prevalence of complications. During the last 30 years, thousands of studies of its use have been performed, but few guidelines are available. Therefore, there is great variability in both the doses and intervals of administration and the approaches taken by clinicians with considerable experience in spasticity and movement disorder treatment...
July 19, 2017: Drugs
https://www.readbyqxmd.com/read/28724781/muscle-disuse-caused-by-botulinum-toxin-injection-leads-to-increased-central-gain-of-the-stretch-reflex-in-the-rat
#7
Jessica Pingel, Hans Hultborn, Lui Naslund-Koch, Dennis Bo Jensen, Jacob Wienecke, Jens Bo Nielsen
Botulinum toxin (Btx) is used in children with cerebral palsy and other neurological patients to diminish spasticity and reduce the risk of development of contractures. Here, we investigated changes in the central gain of the stretch reflex circuitry in response to botulinum toxin injection in the triceps surae muscle in rats. Experiments were performed in 21 rats. 8 rats were in a control group and 13 rats were injected with 6 IU of Btx in the left triceps surae muscle. Two weeks after Btx injection larger monosynaptic reflexes (MSR) were recorded from the left (injected) than the right (non-injected) L4 + L5 ventral roots following stimulation of the corresponding dorsal roots...
July 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28717987/interventions-for-refractory-trigeminal-neuralgia-a-bayesian-mixed-treatment-comparison-network-meta-analysis-of-randomized-controlled-clinical-trials
#8
Kannan Sridharan, Gowri Sivaramakrishnan
INTRODUCTION: Patients with trigeminal neuralgia (TN) are often refractory to recommended first-line agents. Due to the absence of a systematic review, we undertook a network meta-analysis to assess various interventions that can be used to manage refractory TN. METHODS: Electronic databases were searched using appropriate strategies to identify randomized controlled clinical trials in patients with refractory TN, evaluating the proportion of patients with a minimum of 50% reduction in pain or a minimum of 2 cm reduction in score in an appropriate pain scale or complete pain relief by subjective pain scales...
July 17, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28716772/chewing-induced-facial-dystonia-a-rare-presentation-of-task-specific-dystonia
#9
Chandramohan Sharma, Banshi Lal Kumawat, Ankur Garg, Kaushik Kumar Rana
This case is an addition to scarce literature available for a rare condition, chewing-induced task-specific dystonia. The patient was a 63-year-old woman who presented with a 4-year history of progressive difficulty in eating food only during chewing associated with abnormal facial grimaces without any difficulty in drinking, swallowing, speaking or singing. Examination revealed dystonia of facial muscles every time she chewed but absent during drinking and speaking. As movements were consistent and reproducible with the specific task, other differential diagnosis like motor tics, psychogenic disorder, tardive dystonia and parkinsonism syndrome were excluded leading to a diagnosis of task-specific facial dystonia triggered by chewing...
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28716516/hypertonia
#10
Sarah Helen Evans, Mark William Cameron, Justin Michael Burton
Hypertonia is the abnormal increase in muscle tone as a result of upper motor neuron lesions. There are three following clinical types: spasticity, dystonia, and rigidity. Management of hypertonia is individualized and should be directed by the patient and/or family׳s goals of care as well as the underlying cause of the hypertonia. Treatment options include stretching, strengthening, positioning, oral medications, botulinum toxin injections, phenol injections, as well as surgical procedures. Without effective management, hypertonia can result in muscle imbalance, abnormal movement patterns, pain, joint contracture, joint deformity, and ultimately negatively impact a patient׳s function...
July 14, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28716326/disease-specific-outcomes-of-botulinum-toxin-injections-for-neurogenic-detrusor-overactivity
#11
REVIEW
Aaron Kaviani, Rose Khavari
Intradetrusor injection of botulinum toxin A (BTX-A) is an effective option for managing patients with neurogenic detrusor overactivity (NDO) who do not respond to or tolerate oral pharmacologic agents. There is level I evidence that intradetrusor injection of onabotulinumtoxinA for refractory NDO in patients with multiple sclerosis and spinal cord injury is associated with a significantly greater achievement of goals and improved performance in urodynamic studies than placebo. Pilot studies or small case series support BTX-A for NDO in patients with Parkinson's disease and cerebrovascular accident...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28713066/approaches-for-stricture-prevention-after-esophageal-endoscopic-resection
#12
REVIEW
Seiichiro Abe, Prasad G Iyer, Ichiro Oda, Nobuo Kanai, Yutaka Saito
BACKGROUND AND AIMS: Endoscopic resection of extensive esophageal lesions has become more common as endoscopic resection techniques and equipment has developed. However, extensive esophageal endoscopic resections can cause postoperative esophageal strictures, which have a negative impact on the quality of life of patients. We aimed to review current treatments and innovative approaches to prevent esophageal strictures after widespread endoscopic resection of esophageal lesions. METHODS: We performed a comprehensive literature search using predetermined search terms from 2000 to 2016 to identify relevant articles and summarized their results as a narrative review...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28712884/the-supraorbital-region-revisited-an-anatomic-exploration-of-the-neuro-vascular-bundle-with-regard-to-frontal-migraine-headache
#13
Valeria Berchtold, Hannes Stofferin, Bernhard Moriggl, Erich Brenner, Reinhard Pauzenberger, Marko Konschake
BACKGROUND: Recent findings on the pathogenesis of frontal migraine headache support, besides a central vasogenic cause, an alternative peripheral mechanism involving compressed craniofacial nerves. This is further supported by the efficiency of botulinum toxin injections as a new treatment option in frontal migraine headache patients. METHODS: The supraorbital regions of 22 alcohol-glycerine-embalmed facial halves of both sexes were dissected. Both the supratrochlear and supraorbital nerves (STN and SON, respectively) were identified, and their relationship with the corrugator supercilii muscle (CSM) was investigated by dissection and ultrasound...
June 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28712731/cervical-dystonia-patients-display-subclinical-gait-changes
#14
Marcello Esposito, Raffaele Dubbioso, Silvio Peluso, Antonio Picone, Bruno Corrado, Clemente Servodio Iammarone, Roberto Allocca, Fiore Manganelli, Lucio Santoro, Alfonso Fasano
INTRODUCTION: Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities. OBJECTIVE: to assess walking motor pattern in CD patients without DBS and not presenting scoliosis. METHODS: Computerized gait analysis (CGA) was performed in CD patients, before and after botulinum toxin (BoNT) injections, and in healthy controls (HC). Spatiotemporal (ST) parameters were compared between CD and HC groups...
July 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28711166/treatment-of-palmar-hyperhidrosis-by-peripheral-nerve-block-at-the-wrist-with-botulinum-toxin
#15
A de Quintana-Sancho, M T Conde Calvo
No abstract text is available yet for this article.
July 12, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28711104/a-novel-anesthetic-technique-for-palmar-botulinum-toxin-injection
#16
Stephanie T Le, Cody Hanson, Anand N Rajpara, Deede Y Liu, Daniel J Aires
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28710284/the-neuronal-protein-neurexin-directly-interacts-with-the-scribble-pix-complex-to-stimulate-f-actin-assembly-for-synaptic-vesicle-clustering
#17
Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie
Synaptic vesicles (SVs) form distinct pools at synaptic terminals, and this well-regulated separation is necessary for normal neuro-transmission. However, how SV cluster in particular synaptic compartments to maintain normal neurotransmitter release remains a mystery. The presynaptic protein Neurexin (NRX) plays a significant role in synaptic architecture and function, and some evidences suggest that NRX is associated with neurological disorders, including autism spectrum disorders. However, the role of NRX in SV clustering is unclear...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28707196/reversible-association-of-the-hemagglutinin-subcomplex-ha-33-ha-17-trimer-with-the-botulinum-toxin-complex
#18
Yoshimasa Sagane, Shingo Mutoh, Ryosuke Koizumi, Tomonori Suzuki, Shin-Ichiro Miyashita, Keita Miyata, Tohru Ohyama, Koichi Niwa, Toshihiro Watanabe
Botulinum neurotoxin (BoNT) associates with nontoxic proteins, either a nontoxic nonhemagglutinin (NTNHA) or the complex of NTNHA and hemagglutinin (HA), to form M- or L-toxin complexes (TCs). Single BoNT and NTNHA molecules are associated and form M-TC. A trimer of the 70-kDa HA protein (HA-70) attaches to the M-TC to form M-TC/HA-70. Further, 1-3 arm-like 33- and 17-kDa HA molecules (HA-33/HA-17 trimer), consisting of 1 HA-17 protein and 2 HA-33 proteins, can attach to the M-TC/HA-70 complex, yielding 1-, 2-, and 3-arm L-TC...
July 13, 2017: Protein Journal
https://www.readbyqxmd.com/read/28706891/evaluation-of-botulinum-toxin-type-a-effectiveness-in-preventing-postoperative-intraperitoneal-adhesions
#19
Mehmet Dokur, Erdal Uysal
PURPOSE: Postoperative intraperitoneal adhesions (PIAs) are one of the most important problems surgeons have to face after laparotomies. In this study, we aimed to evaluate the effectiveness of local application of botulinum toxin type A (BoNT-A) in various dosages on the prevention of intra-abdominal adhesions in rats with experimental intra-abdominal adhesions. METHODS: Forty Wistar Albino female rats were randomly separated into 4 groups. The 4 groups were determined as follows: Control (group 1, n = 10); Sham (group 2, n = 10); 10-µg/kg low-dose BoNT-A (group 3, n = 10) and 30-µg/kg high-dose BoNT-A (group 4, n = 10)...
July 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28705271/molecular-and-epidemiological-characterization-of-infant-botulism-in-beijing-china
#20
Yin Ping Dong, Wei Wang, Tao Jiang, Jin Xu, Chun Hui Han, Shao Fei Yan, Séamus Fanning, Ying Li, Xiao Chen Ma, Di Zhang, Yao Zhao, Biao Zeng, Feng Qin Li
Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula (PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins (BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis (PFGE) revealed that the two strains of C...
June 2017: Biomedical and Environmental Sciences: BES
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