keyword
https://read.qxmd.com/read/38502104/xevinapant-combined-with-pembrolizumab-in-patients-with-advanced-pretreated-colorectal-and-pancreatic-cancer-results-of-the-phase-1b-2-catripca-trial
#21
JOURNAL ARTICLE
Allison Voisin, Catherine Terret, Camille Schiffler, Anne-Sophie Bidaux, Hélène Vanacker, Marlène Perrin-Niquet, Maud Barbery, Armelle Vinceneux, Lauriane Eberst, Pierre Stephan, Gwenaele Garin, Dany Spaggiari, David Pérol, Yenkel Grinberg-Bleyer, Philippe A Cassier
PURPOSE: Xevinapant is an orally available inhibitor of apoptosis proteins (IAP) inhibitor. Preclinical data suggest that IAP antagonism may synergize with immune checkpoint blockers (ICB) by modulating the NF-KB pathway in immune cells. PATIENTS AND METHODS: Adult patients (pts) with non MSI-H advanced/metastatic PDAC or CRC were enrolled in this phase 1b/2 and received pembrolizumab 200mg q3w, IV and ascending doses of oral xevinapant (100, 150 and 200mg daily for 14 days on/7 days off)...
March 19, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38501838/combining-bulk-and-scrna-seq-to-explore-the-molecular-mechanisms-governing-the-distinct-efferocytosis-activities-of-a-macrophage-subpopulation-in-pdac
#22
JOURNAL ARTICLE
Shaoliang Zhu, Quan Cheng, Mengjie Zou, Chunxing Li, Yi Tang, Longjie Xia, Yanming Jiang, Zheng Gong, Zhenyong Tang, Yuntian Tang, Honglin Luo, Ningfu Peng, Xiaojing Wang, Xiaofeng Dong
Pancreatic ductal adenocarcinoma (PDAC), a very aggressive tumour, is currently the third leading cause of cancer-related deaths. Unfortunately, many patients face the issue of inoperability at the diagnostic phase leading to a quite dismal prognosis. The onset of metastatic processes has a crucial role in the elevated mortality rates linked to PDAC. Individuals with metastatic advances receive only palliative therapy and have a grim prognosis. It is essential to carefully analyse the intricacies of the metastatic process to enhance the prognosis for individuals with PDAC...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38500905/comprehensive-review-on-pancreatic-head-cancer-pathogenesis-diagnosis-and-treatment-challenges-in-the-quest-for-improved-survival
#23
REVIEW
Shreya Singh, Anupama Sawal
This comprehensive review explores the complexities surrounding pancreatic head cancer, a highly fatal and challenging-to-treat illness with a survival rate of less than five years. Despite being a major contributor to cancer-related deaths, pancreatic head malignancy often eludes early detection due to its posterior location and high metastatic potential. The review delves into the associated symptoms, including gastric outlet obstruction and obstructive jaundice, highlighting the impact on the patient's eligibility for surgery...
February 2024: Curēus
https://read.qxmd.com/read/38495490/advances-in-drug-therapy-for-metastatic-pancreatic-ductal-adenocarcinoma
#24
REVIEW
Jianjun Gao, Jiangang Wang, Canghai Guan, Wujiang Shi, Qingfu Dong, Jialin Sheng, Xinlei Zou, Zhaoqiang Xu, Yifei Ge, Ziyue Huang, Jiehan Li, Haolin Bao, Yi Xu, Yunfu Cui, Xiaoxue Xu, Xiangyu Zhong
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis. A large number of patients with PDAC develop metastases before they are diagnosed with metastatic pancreatic cancer (mPDAC). For mPDAC, FOLFIRINOX or gemcitabine plus nab-paclitaxel are the current first-line treatments. It is important to note, however, that many patients will fail chemotherapy because of drug resistance. ​Heterogeneous tumors and complex tumor microenvironments are key factors. As a result, clinical researchers are exploring a variety of alternative treatment modalities...
2024: Journal of Cancer
https://read.qxmd.com/read/38495381/genetic-alterations-in-the-neuronal-development-genes-are-associated-with-changes-of-the-tumor-immune-microenvironment-in-pancreatic-cancer
#25
JOURNAL ARTICLE
Kaiyi Mu, Juan Fu, Jessica Gai, Harshitha Ravichandran, Lei Zheng, Wei-Chih Sun
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is highly metastatic. Our prior studies have demonstrated the critical role of axon guidance pathway genes in PDAC and the connection between neuronal development and the tumor microenvironment. A recent study newly identified 20 neuronal development genes [disks large homolog 2 ( DLG2 ), neuron-glial-related cell adhesion molecule ( NRCAM ), neurexin3 ( NRXN3 ), mitogen-activated protein kinase 10 ( MAPK10 ), platelet-derived growth factor D ( PDGFD ), protein kinase C epsilon ( PRKCE ), potassium calcium-activated channel subfamily M alpha 1 ( KCNMA1 ), polycystic kidney and hepatic disease 1 ( PKHD1 ), neural cell adhesion molecule 1 ( NCAM1 ), neuregulin-1 ( NRG1 ), zinc finger protein 667 ( ZNF667 ), cystic fibrosis transmembrane conductance regulator ( CFTR ), acyl-CoA medium-chain synthetase-3 ( ACSM3 ), complement 6 ( C6 ), protein tyrosine phosphatase receptor type M ( PTPRM ), hypoxia-inducible factor 1 alpha ( HIF1A ), adenylyl cyclase 5 ( ADCY5 ), adherens junctions-associated protein 1 ( AJAP1 ), neurobeachin ( NBEA ), sodium voltage-gated channel alpha subunit 9 ( SCN9A )] that are associated with perineural invasion and poor prognosis of PDAC...
November 2023: Annals of Pancreatic Cancer
https://read.qxmd.com/read/38489997/synthesis-and-biological-activity-of-11-oxygenated-and-heterocyclic-estrone-analogs-in-pancreatic-cancer-monolayers-and-3d-spheroids
#26
JOURNAL ARTICLE
Khaled Alseud, Trevor Ostlund, Mikhail Durymanov, Joshua Reineke, Fathi Halaweish
Pancreatic Ductal Adenocarcinoma (PDAC), representing over 90 % of pancreatic cancer diagnoses, is an aggressive disease with survivability among the worst of all cancers due to its difficulty in detection and its high metastatic properties. Current therapies for PDAC show limited success at extending life expectancies, primarily due to cancer resistance and lack of patient-specific targeted therapies. This work highlights the design and evaluation of estrone-derived analogs with both heterocyclic side-chain functionality and 11-oxygenated functionality for use in pancreatic cancer...
March 5, 2024: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/38487523/complete-remission-of-advanced-pancreatic-cancer-induced-by-claudin18-2-targeted-car-t-cell-therapy-a-case-report
#27
Guocheng Zhong, Xiaomin Zhang, Zheng Guo, Yujie Gao, Bochen Zhao, Xianhao Liu, Lei Chen, Jingqiao Qiao, Chuan Yu, Lixin Wang, Yisheng Li, Li Yu
Pancreatic cancer (PC) is one of the most malignant tumors in digestive system due to its highly invasive and metastatic properties. At present, conventional treatment strategies for PC show the limited clinical efficacy. Therefore, novel effective therapeutic strategies are urgently needed. Here, we report a case of complete remission of advanced PC induced by claudin18.2-targeted CAR-T cell therapy. The patient was a 72-year-old man who was diagnosed with pancreatic ductal adenocarcinoma 2 years ago, and he experienced tumor recurrence and multiple metastases after pancreaticoduodenectomy and multi-line chemotherapies, including liver, peritoneum, and cervical lymph node metastases...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487000/discovery-of-a-potent-and-highly-selective-inhibitor-of-sirt6-against-pancreatic-cancer-metastasis-in%C3%A2-vivo
#28
JOURNAL ARTICLE
Xinyuan Xu, Qian Zhang, Xufeng Wang, Jing Jin, Chengwei Wu, Li Feng, Xiuyan Yang, Mingzhu Zhao, Yingyi Chen, Shaoyong Lu, Zhen Zheng, Xiaobing Lan, Yi Wang, Yan Zheng, Xuefeng Lu, Qiufen Zhang, Jian Zhang
Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastasis. SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer. However, highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered. Here, we developed a novel SIRT6 allosteric inhibitor, compound 11e , with maximal inhibitory potency and an IC50 value of 0...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38480544/postbiotic-butyrate-role-and-its-effects-for-being-a-potential-drug-and-biomarker-to-pancreatic-cancer
#29
REVIEW
Abinaya Elango, Vineeta Debbie Nesam, Padmaja Sukumar, Infancia Lawrence, Arunkumar Radhakrishnan
Postbiotics are produced by microbes and have recently gained importance in the field of oncology due to their beneficial effects to the host, effectiveness against cancer cells, and their ability to suppress inflammation. In particular, butyrate dominates over all other postbiotics both in quantity and anticancer properties. Pancreatic cancer (PC), being one of the most malignant and lethal cancers, reported a decreased 5-year survival rate in less than 10% of the patients. PC causes an increased mortality rate due to its inability to be detected at an early stage but still a promising strategy for its diagnosis has not been achieved yet...
March 13, 2024: Archives of Microbiology
https://read.qxmd.com/read/38478609/clonal-dominance-defines-metastatic-dissemination-in-pancreatic-cancer
#30
JOURNAL ARTICLE
I-Lin Ho, Chieh-Yuan Li, Fuchenchu Wang, Li Zhao, Jingjing Liu, Er-Yen Yen, Charles A Dyke, Rutvi Shah, Zhaoliang Liu, Ali Osman Çetin, Yanshuo Chu, Francesca Citron, Sergio Attanasio, Denise Corti, Faezeh Darbaniyan, Edoardo Del Poggetto, Sara Loponte, Jintan Liu, Melinda Soeung, Ziheng Chen, Shan Jiang, Hong Jiang, Akira Inoue, Sisi Gao, Angela Deem, Ningping Feng, Haoqiang Ying, Michael Kim, Virginia Giuliani, Giannicola Genovese, Jianhua Zhang, Andrew Futreal, Anirban Maitra, Timothy Heffernan, Linghua Wang, Kim-Anh Do, Gaetano Gargiulo, Giulio Draetta, Alessandro Carugo, Ruitao Lin, Andrea Viale
Tumors represent ecosystems where subclones compete during tumor growth. While extensively investigated, a comprehensive picture of the interplay of clonal lineages during dissemination is still lacking. Using patient-derived pancreatic cancer cells, we created orthotopically implanted clonal replica tumors to trace clonal dynamics of unperturbed tumor expansion and dissemination. This model revealed the multifaceted nature of tumor growth, with rapid changes in clonal fitness leading to continuous reshuffling of tumor architecture and alternating clonal dominance as a distinct feature of cancer growth...
March 15, 2024: Science Advances
https://read.qxmd.com/read/38477638/evaluation-of-pancreatic-cancer-specimens-for-comprehensive-genomic-profiling
#31
JOURNAL ARTICLE
Kota Washimi, Yukihiko Hiroshima, Shinya Sato, Makoto Ueno, Satoshi Kobayashi, Naoto Yamamoto, Chie Hasegawa, Emi Yoshioka, Kyoko Ono, Yoichiro Okubo, Tomoyuki Yokose, Yohei Miyagi
Inadequate specimen quality or quantity hinders comprehensive genomic profiling in identifying actionable mutations and guiding treatment strategies. We investigated the optimal conditions for pancreatic cancer specimen selection for comprehensive genomic profiling. We retrospectively analyzed 213 pancreatic cancer cases ordered for comprehensive genomic profiling and compared results from pancreatic biopsy, liver biopsy of pancreatic cancer metastases, pancreatectomy, liquid, and nonliver metastatic organ specimens...
March 13, 2024: Pathology International
https://read.qxmd.com/read/38473820/the-conjugates-of-indolo-2-3-b-quinoline-as-anti-pancreatic-cancer-agents-design-synthesis-molecular-docking-and-biological-evaluations
#32
JOURNAL ARTICLE
Marcin Cybulski, Katarzyna Sidoryk, Magdalena Zaremba-Czogalla, Bartosz Trzaskowski, Marek Kubiszewski, Joanna Tobiasz, Anna Jaromin, Olga Michalak
New amide conjugates of hydroxycinnamic acids (HCAs) and the known antineoplastic 5,11-dimethyl-5 H -indolo[2,3- b ]quinoline (DiMIQ), an analog of the natural alkaloid neocryptolepine, were synthesized and tested in vitro for anticancer activity. The compound 9-[((2-hydroxy)cinnamoyl)amino]-5,11-dimethyl-5 H -indolo[2,3- b ]quinoline ( 2 ), which contains the ortho-coumaric acid fragment, demonstrated dose-dependent effectiveness against both normal BxPC-3 and metastatic AsPC-1 pancreatic cancer cells. The IC50 values for AsPC-1 and BxPC-3 were 336...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473242/a-15-year-single-institution-retrospective-study-of-primary-pancreatic-cancer-treated-with-non-ablative-palliative-radiotherapy
#33
JOURNAL ARTICLE
Randa Kamel, Tinghua Zhang, Suzanne Comino, Kristopher Dennis
We studied the use of palliative radiotherapy (RT) among patients with primary, non-curable, locally advanced pancreatic cancer. In this subset of patients, with very poor survival, various palliative RT dose fractionation schemes are used; but, in the absence of a guideline, practice patterns vary, and dose choice is mainly based on the physician's intuition. We divided the patients into three groups, according to the dose fractionation schedules received: low (A), intermediate (B), and high (C) dose groups, to study the potential differences in outcome between the different dose prescriptions...
February 22, 2024: Cancers
https://read.qxmd.com/read/38461085/mainstream-model-of-genetic-testing-for-prostate-cancer-at-a-large-tertiary-cancer-centre
#34
JOURNAL ARTICLE
Xin Wang, Larissa Waldman, Yael Silberman, Michael Wang, Caleb Tackey, Lilian Hanna, Danny Vesprini, Urban Emmenegger, Andrea Eisen, Martin Smoragiewicz
BACKGROUND: An estimated 20% to 30% of men with advanced prostate cancer carry a mutation in DNA damage repair genes, of which half are estimated to be germline. Eligibility criteria for germline genetic testing expanded significantly for Ontario patients in May 2021 and many centers adopted a "mainstream" model, defined as oncologist-initiated genetic testing. METHODS: We conducted a retrospective chart review to report on the first-year mainstream experience of a large tertiary oncologic center, the Sunnybrook Odette Cancer Centre...
February 12, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38456344/identification-of-pancreatic-metastasis-cells-and-cell-spheroids-by-the-organelle-targeting-sensor-array
#35
JOURNAL ARTICLE
Guoyang Zhang, Zirui Wang, Lijun Ma, Jiguang Li, Jiahao Han, Mingguang Zhu, Zixuan Zhang, Shilong Zhang, Xin Zhang, Zhuo Wang
Pancreatic cancer is a highly malignant and metastatic cancer. Pancreatic cancer can lead to liver metastases, gallbladder metastases, and duodenum metastases. The identification of pancreatic cancer cells is essential for the diagnosis of metastatic cancer and exploration of carcinoma in situ. Organelles play an important role in maintaining the function of cells, the various cells show significant difference in organelle microenvironment. Herein, six probes were synthesized for targeting mitochondria, lysosomes, cell membranes, endoplasmic reticulum, Golgi apparatus, and lipid droplets...
March 8, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38454247/the-supression-of-migration-and-metastasis-via-inhibition-of-vascular-endothelial-growth-factor-in-pancreatic-adenocarcinoma-cells-applied-danusertib
#36
JOURNAL ARTICLE
Erkan Alabaş, Ahmet Ata Özçimen
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma is an extremely deadly type of cancer with a high metastatic potential. Genetic factors in cellular events play an important role in the emergence of this situation. One of these factors is Aurora kinase family members, which play a role in migration, invasion, and cell cycle. In this study, the expression of vascular endothelial growth factor gene, which plays a role in migration, metastasis, and angiogenesis, on cystic fibrosis human pancreatic ductal adenocarcinoma 1 cells of danusertib, a pan-Aurora kinase inhibitor, was examined...
February 2024: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://read.qxmd.com/read/38452581/the-mechanisms-behind-the-dual-role-of-long-non-coding-rna-lncrna-metastasis-suppressor-1-in-human-tumors-shedding-light-on-the-molecular-mechanisms
#37
REVIEW
Bekhzod Abdullaev, Hashem O Alsaab, Ahmed Hjazi, Adnan Taan Alkhafaji, Ahmed Hussien Alawadi, Hamza Fadhel Hamzah
When the expression levels of metastasis suppressor-1 (MTSS1) were discovered to be downregulated in a metastatic cancer cell line in 2002, it was proposed that MTSS1 functioned as a suppressor of metastasis. The 755 amino acid long protein MTSS1 connects to actin and organizes the cytoskeleton. Its gene is located on human chromosome 8q24. The suppressor of metastasis in metastatic cancer was first found to be MTSS1. Subsequent reports revealed that MTSS1 is linked to the prevention of metastasis in a variety of cancer types, including hematopoietic cancers like diffuse large B cell lymphoma and esophageal, pancreatic, and stomach cancers...
February 16, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452580/cadherin-17-cdh17-expression-in-human-cancer-a-tissue-microarray-study-on-18-131-tumors
#38
JOURNAL ARTICLE
Frank Jacobsen, Ramesh Pushpadevan, Florian Viehweger, Morton Freytag, Ria Schlichter, Natalia Gorbokon, Franziska Büscheck, Andreas M Luebke, Devita Putri, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Sarah Minner, Stefan Steurer, Ronald Simon, Eike Burandt, David Dum, Florian Lutz, Andreas H Marx, Till Krech, Till S Clauditz
Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 is therefore considered a possible diagnostic and therapeutic target. This study was to comprehensively determine the expression of CDH17 in cancer and to further assess the diagnostic utility of CDH17 immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types and subtypes as well as 76 different normal tissue types was analyzed by IHC...
January 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38449408/-a-patient-with-cancer-of-unknown-primary-who-responded-to-chemotherapy
#39
JOURNAL ARTICLE
Akira Takama, Manabu Iwadate, Shigeyuki Tsukita, Hiromichi Ohira
Cancer of unknown primary is a class of malignant tumors, histologically identified as metastatic lesions whose primary origin is unknown despite adequate investigations for the primary tumor. Although the prognosis of cancer of unknown primary is generally poor, here, we report our experience with a patient who responded to chemotherapy. The patient was a 78-year-old woman. She had a history of gastric cancer at the age of 76 years. In June of year X-1, she was diagnosed with gastric cancer(tub1>tub2, pT1bN0M0, pStage Ⅰa)and underwent distal gastrectomy...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38448752/early-onset-pancreatic-cancer-exploring-contemporary-treatment-and-outcomes-using-real-world-data
#40
JOURNAL ARTICLE
Shehara Mendis, Lara Lipton, Yat Hang To, Sumitra Ananda, Michael Michael, Sue-Anne McLachlan, Benjamin Thomson, Benjamin Loveday, Brett Knowles, Adrian Fox, Mehrdad Nikfarjam, Val Usatoff, Julia Shapiro, Kate Clarke, Sharon Pattison, Cheng Ean Chee, Rob Zielinski, Rachel Wong, Peter Gibbs, Belinda Lee
BACKGROUND: Pancreatic cancer incidence is increasing in younger populations. Differences between early onset pancreatic cancer (EOPC) and later onset pancreatic cancer (LOPC), and how these should inform management warrant exploration in the contemporary setting. METHODS: A prospectively collected multi-site dataset on consecutive pancreatic adenocarcinoma patients was interrogated. Patient, tumour, treatment, and outcome data were extracted for EOPC (≤50 years old) vs LOPC (>50 years old)...
March 6, 2024: British Journal of Cancer
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