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Growth modulation index

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https://www.readbyqxmd.com/read/29680483/iontophoresis-stimulated-silk-fibroin-films-as-a-peptide-delivery-system-for-wound-healing
#1
Camila Nunes Lemos, Camila Cubayachi, Karina Dias, Jacqueline Nakau Mendonça, Norberto Peporine Lopes, Niege Araçari Jacometti Cardoso Furtado, Renata F V Lopez
Silk fibroin (SF) films containing a peptide, neurotensin (NT), stimulated by iontophoresis were developed with an aim to modulate the inflammatory process and prevent the growth of microorganisms typical of wounds. NT-loaded SF films composition shows predominance of β-sheet structures that conferred adequate mechanical properties, transparency, moderate roughness and low swelling index to fibroin films. Infrared spectroscopy and thermal analysis suggested the presence of non-covalent interactions between NT and fibroin...
April 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29657669/dual-effect-of-photobiomodulation-on-melasma-downregulation-of-hyperpigmentation-and-enhanced-solar-resistance-a-pilot-study
#2
Daniel Barolet
Overview. Melasma is a resistant, sun-induced facial hyperpigmentation capable of remaining present for decades with ensuing psychological distress. Treatment is difficult and focuses on an array of measures to reduce skin hyperpigmentation resulting from triggered hyperactive melanocytes. The pathogenesis of melanoma is not clearly understood but it has been reported that some growth factors and specific cell-signaling pathways are involved. Objective. The objective of the current study was to evaluate the use of pulsed photobiomodulation to modulate melasma via the regulation of gene expression pertaining to skin pigmentation...
April 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29616235/effect-of-water-quality-sanitation-hand-washing-and-nutritional-interventions-on-child-development-in-rural-bangladesh-wash-benefits-bangladesh-a-cluster-randomised-controlled-trial
#3
Fahmida Tofail, Lia Ch Fernald, Kishor K Das, Mahbubur Rahman, Tahmeed Ahmed, Kaniz K Jannat, Leanne Unicomb, Benjamin F Arnold, Sania Ashraf, Peter J Winch, Patricia Kariger, Christine P Stewart, John M Colford, Stephen P Luby
Background: Poor nutrition and hygiene make children vulnerable to delays in growth and development. We aimed to assess the effects of water quality, sanitation, handwashing, and nutritional interventions individually or in combination on the cognitive, motor, and language development of children in rural Bangladesh. Methods: In this cluster-randomised controlled trial, we enrolled pregnant women in their first or second trimester from rural villages of Gazipur, Kishoreganj, Mymensingh, and Tangail districts of central Bangladesh, with an average of eight women per cluster...
April 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/29613885/hormone-therapy-in-menopausal-women-with-fibroids-is-it-safe
#4
Vedhapriya Srinivasan, Mark G Martens
Menopause is an important transition in the life of women. It has been estimated that by the year 2030, worldwide 1.2 billion women will be menopausal. The most bothersome symptoms of menopause are believed to be due to declines in estrogen levels in postmenopausal women. Thus, hormone therapy is an effective treatment option for menopausal women, although prolonged use of hormone therapy is associated with a slightly increased risk of breast cancer, thromboembolism, and stroke. A literature search for studies evaluating the effects of hormone therapy in menopausal women with asymptomatic fibroids demonstrated variable effects of hormone therapy on the volume and size of the fibroids...
April 2, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29568321/evaluation-of-treatment-effect-with-paired-failure-times-in-a-single-arm-phase-ii-trial-in-oncology
#5
Matthieu Texier, Federico Rotolo, Michel Ducreux, Olivier Bouché, Jean-Pierre Pignon, Stefan Michiels
In early phase clinical trials of cytotoxic drugs in oncology, the efficacy is typically evaluated based on the tumor shrinkage. However, this criterion is not always appropriate for more recent cytostatic agents, and alternative endpoints have been proposed. The growth modulation index (GMI), defined as the ratio between the times to progression in two successive treatment lines, has been proposed for a single-arm phase II trials. The treatment effect is evaluated by estimating the rate of patients having a GMI superior to a given threshold...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29567171/determination-of-fermentable-sugars-in-beer-wort-by-gold-nanoparticles-polydopamine-a-layer-by-layer-approach-for-localized-surface-plasmon-resonance-measurements-at-fixed-wavelength
#6
S Scarano, E Pascale, P Palladino, E Fratini, M Minunni
Polydopamine decorated in-situ with Localized Surface Plasmon Resonance (LSPR)-active gold nanoparticles (AuNPs) may extend the applicability of nanoplasmonic materials to original and innovative applications in several fields. Here we report the modification of disposable UV-Vis polystyrene cuvettes with AuNPs@PDA for refractive index LSPR-based measurements. An original layer-by-layer deposition method of PDA followed by AuNPs growth is here developed, showing linear correlation between PDA thickness and optical properties...
June 1, 2018: Talanta
https://www.readbyqxmd.com/read/29514292/phytochrome-b-regulates-resource-allocation-in-brassica-rapa
#7
Andrej A Arsovski, Joseph Zemke, Benjamin D Haagen, Soo-Hyung Kim, Jennifer L Nemhauser
Crop biomass and yield are tightly linked to how the light signaling network translates information about the environment into allocation of resources, including photosynthates. Once activated, the phytochrome (phy) class of photoreceptors signal and re-deploy carbon resources to alter growth, plant architecture and reproductive timing. Most of the previous characterization of the light-modulated growth program has been performed in the reference plant Arabidopsis thaliana. Here, we use Brassica rapa as a crop model to test for conservation of the phytochrome-carbon network...
March 3, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29475266/analyses-of-multi-color-plant-growth-light-sources-in-achieving-maximum-photosynthesis-efficiencies-with-enhanced-color-qualities
#8
Tingzhu Wu, Yue Lin, Lili Zheng, Ziquan Guo, Jianxing Xu, Shijie Liang, Zhuguagn Liu, Yijun Lu, Tien-Mo Shih, Zhong Chen
An optimal design of light-emitting diode (LED) lighting that benefits both the photosynthesis performance for plants and the visional health for human eyes has drawn considerable attention. In the present study, we have developed a multi-color driving algorithm that serves as a liaison between desired spectral power distributions and pulse-width-modulation duty cycles. With the aid of this algorithm, our multi-color plant-growth light sources can optimize correlated-color temperature (CCT) and color rendering index (CRI) such that photosynthetic luminous efficacy of radiation (PLER) is maximized regardless of the number of LEDs and the type of photosynthetic action spectrum (PAS)...
February 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29450728/winter-vitamin-d-3-supplementation-does-not-increase-muscle-strength-but-modulates-the-igf-axis-in-young-children
#9
Charlotte Mortensen, Christian Mølgaard, Hanne Hauger, Michael Kristensen, Camilla T Damsgaard
PURPOSE: To explore whether muscle strength, the insulin-like growth factor axis (IGF-axis), height, and body composition were associated with serum 25-hydroxyvitamin D [25(OH)D] and affected by winter vitamin D supplementation in healthy children, and furthermore to explore potential sex differences. METHODS: We performed a double-blind, placebo-controlled, dose-response winter trial at 55ºN. A total of 117 children aged 4-8 years were randomly assigned to either placebo, 10, or 20 µg/day of vitamin D3 for 20 weeks...
February 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29377526/low-maternal-vitamin-d-status-in-pregnancy-increases-the-risk-of-childhood-obesity
#10
V Daraki, T Roumeliotaki, G Chalkiadaki, M Katrinaki, M Karachaliou, V Leventakou, M Vafeiadi, K Sarri, M Vassilaki, S Papavasiliou, M Kogevinas, L Chatzi
BACKGROUND: Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results. OBJECTIVES: The objective of this study is to examine the association of maternal 25(OH)-vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother-child pairs from the prospective pregnancy cohort Rhea in Crete, Greece...
January 28, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29361981/intraoperative-brief-electrical-stimulation-of-the-spinal-accessory-nerve-best-spin-for-prevention-of-shoulder-dysfunction-after-oncologic-neck-dissection-a-double-blinded-randomized-controlled-trial
#11
Brittany Barber, Hadi Seikaly, K Ming Chan, Rhys Beaudry, Shannon Rychlik, Jaret Olson, Matthew Curran, Peter Dziegielewski, Vincent Biron, Jeffrey Harris, Margaret McNeely, Daniel O'Connell
BACKGROUND: Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). Brief electrical stimulation (BES) is a novel technique that has been shown to enhance neuronal regeneration after nerve injury by modulating the brain-derived neurotrophic growth factor (BDNF) pathways. The objective of this study was to evaluate the effect of BES on postoperative shoulder function following oncologic neck dissection. METHODS: Adult participants with a new diagnosis of HNC undergoing Level IIb +/- V neck dissection were recruited...
January 23, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29350442/role-of-ethylene-and-related-gene-expression-in-the-interaction-between-strawberry-plants-and-the-plant-growth-promoting-bacterium-azospirillum-brasilense
#12
J M Elías, M F Guerrero-Molina, M G Martínez-Zamora, J C Díaz-Ricci, R O Pedraza
Induced systemic resistance (ISR) is one of the indirect mechanisms of growth promotion exerted by plant growth-promoting bacteria, and can be mediated by ethylene (ET). We assessed ET production and the expression of related genes in the Azospirillum-strawberry plant interaction. Ethylene production was evaluated by gas chromatography in plants inoculated or not with A. brasilense REC3. Also, plants were treated with AgNO3 , an inhibitor of ET biosynthesis; with 1-aminocyclopropane-1-carboxylic acid (ACC), a precursor of ET biosynthesis; and with indole acetic acid (IAA)...
May 2018: Plant Biology
https://www.readbyqxmd.com/read/29328383/oxymatrine-protects-against-the-effects-of-cardiopulmonary-resuscitation-via-modulation-of-the-tgf-%C3%AE-1-smad3-signaling-pathway
#13
Dawei Wang, Xiao Qian Lou, Xiao-Ming Jiang, Chenxi Yang, Xiao-Liang Liu, Nan Zhang
Previous studies have demonstrated that oxymatrine may inhibit ventricular remodeling and serves an important role in the treatment of cardiovascular disease. The present study investigated whether oxymatrine treatment protects against the effects of cardiopulmonary resuscitation (CPR) via regulation of the transforming growth factor‑β1 (TGF‑β1)/mothers against decapentaplegic (Smad) signaling pathway. A CPR model was established in Sprague‑Dawley (SD) rats by asphyxiation, and rats were subsequently anaesthetized by intraperitoneal injection of chloral hydrate...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29306033/a-glyphosate-micro-emulsion-formulation-displays-teratogenicity-in-xenopus-laevis
#14
Patrizia Bonfanti, M Saibene, R Bacchetta, P Mantecca, A Colombo
Glyphosate is the active ingredient in broad-spectrum herbicide formulations used in agriculture, domestic area and aquatic weed control worldwide. Its market is growing steadily concurrently with the cultivation of glyphosate-tolerant transgenic crops and emergence of weeds less sensitive to glyphosate. Ephemeral and lentic waters near to agricultural lands, representing favorite habitats for amphibian reproduction and early life-stage development, may thus be contaminated by glyphosate based herbicides (GBHs) residues...
February 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29304104/developmental-and-reproductive-performance-of-a-specialist-herbivore-depend-on-seasonality-of-and-light-conditions-experienced-by-the-host-plant
#15
Osariyekemwen O Uyi, Costas Zachariades, Lelethu U Heshula, Martin P Hill
Host plant phenology (as influenced by seasonality) and light-mediated changes in the phenotypic and phytochemical properties of leaves have been hypothesised to equivocally influence insect herbivore performance. Here, we examined the effects of seasonality, through host plant phenology (late growth-season = autumn vs flowering-season = winter) and light environment (shade vs full-sun habitat) on the leaf characteristics of the invasive alien plant, Chromolaena odorata. In addition, the performance of a specialist folivore, Pareuchaetes insulata, feeding on leaves obtained from both shaded and full-sun habitats during autumn and winter, was evaluated over two generations...
2018: PloS One
https://www.readbyqxmd.com/read/29259730/assessment-of-bacterial-communities-of-black-soybean-grown-in-fields
#16
Akifumi Sugiyama, Yusuke Unno, Ui Ono, Emon Yoshikawa, Hideyuki Suzuki, Kiwamu Minamisawa, Kazufumi Yazaki
Since the domestication of soybean ( Glycine max ) about 4,500 years ago, thousands of local cultivars have been developed around the world. In Japan, black soybeans grown in the mountainous region of central Kyoto and Hyogo prefectures, called the Tamba region, are well known for large seeds and palatability. The yields of black soybean in the Tamba region of Kyoto have decreased during the past few decades, and the involvement of rhizosphere microbes in the yield decline has been suggested. We analyzed bacterial communities of the soybean rhizosphere on 7 farms managed under different strategies...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/29228616/microrna-610-inhibits-tumor-growth-of-melanoma-by-targeting-lrp6
#17
Guangjing Zhang, Dongfang Ai, Xiufang Yang, Shanshan Ji, Zhengxiang Wang, Shijun Feng
Accumulating evidence showed that aberrant miRNAs expression was involved in initiation and progression of melanoma. However, the investigation of different miRNAs in melanoma remain attractive. In this research, we demonstrated that miR-610 expression was decreased in melanoma tissues and cell lines. The clinical data showed that the reduced miR-610 expression was obviously associated with adverse prognostic characteristics. Furthermore, our results suggested that miR-610 had a function of prognostic indicator for 5-year predicted-survival of melanoma patients...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176061/exhaled-breath-temperature-in-optimally-treated-asthmatics-severity-and-underlying-mechanisms
#18
Polyxeni Ntontsi, Petros Bakakos, Evgenia Papathanasiou, Zoi Tsilogianni, Konstantinos Kostikas, Georgios Hillas, Georgios Papatheodorou, Nikolaos Koulouris, Spyros Papiris, Stelios Loukides
INTRODUCTION: Increased vascularity may lead to loss of heat in the airways and may modulate exhaled breath temperature (EBT). Increased EBT has been associated with uncontrolled asthma. AIM: We wanted to determine whether the measurement of EBT in optimally treated asthmatic patients is influenced by the increased vascular permeability and whether Vascular endothelial growth factor (VEGF) is implicated in the above process. Furthermore, to assess the impact of asthma severity on EBT values...
February 20, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29146648/economic-evaluation-of-an-e-mental-health-intervention-for-patients-with-retinal-exudative-diseases-who-receive-intraocular-anti-vegf-injections-e-pseye-protocol-for-a-randomised-controlled-trial
#19
Hilde P A van der Aa, Ger H M B van Rens, Frank D Verbraak, Machteld Bosscha, Marc A Koopmanschap, Hannie C Comijs, Pim Cuijpers, Ruth M A van Nispen
INTRODUCTION: Because of the great potential of vascular endothelial growth factor inhibitors (anti-VEGF) for retinal exudative diseases, an increased number of patients receives this treatment. However, during this treatment, patients are subjected to frequent invasive intravitreal injections, and the effects on reversing the process of vision loss are uncertain, which may have negative consequences for patients' mental health. One in three patients experience at least mild symptoms of depression/anxiety...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132432/ac-93253-iodide-a-novel-src-inhibitor-suppresses-nsclc-progression-by-modulating-multiple-src-related-signaling-pathways
#20
Yi-Hua Lai, Sih-Yin Lin, Yu-Shan Wu, Huei-Wen Chen, Jeremy J W Chen
BACKGROUND: The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and motility and to investigate the molecular mechanisms underlying the effects of these compounds. METHODS: Human non-small cell lung cancer (NSCLC) cell lines (PC9, PC9/gef, A549, and H1975) with different EGFR statuses were tested by cytotoxicity and proliferation assays after AC-93253 iodide treatment...
November 13, 2017: Journal of Hematology & Oncology
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