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Growth modulation index

Zoran Meštrović, Damir Roje, Marko Vulić, Mirela Zec
BACKGROUND: Optimal gestational weight gain has not yet been clearly defined and remains one of the most controversial issues in modern perinatology. The role of optimal weight gain during pregnancy is critical, as it has a strong effect on perinatal outcomes. PURPOSE: In this study, gestational body mass index (BMI) change, accounting for maternal height, was investigated as a new criterion for gestational weight gain determination, in the context of fetal growth assessment...
October 14, 2016: Archives of Gynecology and Obstetrics
Diego Safian, Roberto D Morais, Jan Bogerd, Rüdiger W Schulz
Insulin-like growth factor (Igf) binding proteins (Igfbps) modulate the availability of Igfs for their cognate receptors. In zebrafish testes, Igf3 promotes the proliferation and differentiation of type A undifferentiated (Aund) spermatogonia, and igf3 expression is strongly elevated by Fsh, but also responds to T3. Here, we report the effects of Fsh and T3 on igfbp transcript levels in adult zebrafish testis. We then examined T3 and Fsh effects on zebrafish spermatogenesis and explored the relevance of Igfbps in modulating these T3 or Fsh effects, using a primary tissue culture system for adult zebrafish testis...
September 30, 2016: Endocrinology
N Nikoloff, M V Ponzinibbio, G Padula, J C De Luca, C D Golijow, A Seoane
In human tumor cells, experimental and clinical evidence indicates that some factors involved in signal transduction and cell growth can also modulate the response to chemotherapeutic treatment. The aim of the present study was to investigate the role of folic acid (FA) as a modulator of carboplatin (CBDCA) activity. Genotoxicity and cytotoxicity induced by CBDCA alone and in combination with FA were assessed in cultured HeLa cells. We used comet assay, mitotic index analysis, MTT and NR assays, cytokinesis-block micronucleus cytome assay and annexin V-IP as different cytotoxicity and genotoxicity approaches for human cervical carcinoma cell line studies...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Abid Hussain, Muhammad Rizwan-Ul-Haq, Hassan Al-Ayedh, Ahmed Mohammed AlJabr
Insects infected with entomopathogenic fungi, experience physiological changes that influence their growth and immune defence. The potential of nine isolates of entomopathogenic fungi was evaluated after determining percent germination and relative conidial hydrophobicity. However, nutritional indices were evaluated after immersing eighth-instar Rhynchophorus ferrugineus larvae into each isolate suspension (1 × 10⁷ conidia/mL). The results showed that isolates B6884 and M9374 had 44.51% and 39.02% higher conidial hydrophobicity compared with isolate I03011 (least virulent)...
2016: International Journal of Molecular Sciences
Patricio Araos, David Mondaca, Jorge E Jalil, Cristián Yañez, Ulises Novoa, Italo Mora, María Paz Ocaranza
BACKGROUND: Diuretics are current antihypertensive drugs since they reduce blood pressure and cardiovascular risk. Increased vascular tone is modulated in a relevant way by the RhoA/Rho-kinase (ROCK) pathway, by acting on vascular smooth muscle cell contraction. This pathway has also proremodeling vascular effects. There are few data on the role of diuretics on both vascular ROCK activation and on proremodeling effects. We assessed the effects of hydrochlorothiazide (HCTZ) and spironolactone (spiro) alone and in combination with the ROCK inhibitor fasudil (FAS) on ROCK activation, gene expression of proremodeling markers and on hypertrophy in the aortic wall of hypertensive rats...
September 1, 2016: Therapeutic Advances in Cardiovascular Disease
Clara Maria Pinheiro-Dardis, Thiago Luiz Russo
OBJECTIVE: The aim of this work was to investigate the effects of electrical stimulation (ES) of denervated muscles of rat in neuromuscular performance, muscle atrophy, and fibrosis formation. DESIGN: Wistar rats were divided into normal (N), 7- or 15-day denervation (D7d and D15d), D7d or D15d plus ES (DES7d and DES15d, respectively). Sciatic nerves were crushed causing muscle denervation. Two hundred muscle contractions were electrically induced daily by surface electrodes, considering muscle chronaxie...
August 31, 2016: American Journal of Physical Medicine & Rehabilitation
Umesh T Sankpal, Susan B Ingersoll, Sarfraz Ahmad, Robert W Holloway, Vadiraja B Bhat, Jerry W Simecka, Liz Daniel, Ekamber Kariali, Jamboor K Vishwanatha, Riyaz Basha
The expression of specificity protein 1 (Sp1) and survivin was evaluated in clinical specimens of epithelial ovarian cancer (EOC) patients. When compared to normal tissue, EOC samples showed high expression of Sp1 and survivin using qPCR (Sp1: ∼2-fold; survivin: ∼5-fold) and Western blot (Sp1: >2.6-fold; survivin: >100-fold). The Sp1 inhibitor, and anti-cancer small molecule, tolfenamic acid (TA), was tested to enhance the response of Cisplatin (Cis) in EOC cell lines. Cell viability (CellTiter-Glo), combination index (CalcuSyn software), apoptosis (Annexin-V staining), cell cycle analyses (flow cytometry), and reactive oxygen species (flow cytometry) were determined...
August 31, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Madeline R Carins Murphy, Gregory J Jordan, Timothy J Brodribb
BACKGROUND AND AIMS: It has been proposed that modification of leaf size, driven by epidermal cell size, balances leaf water supply (determined by veins) with transpirational demand (generated by stomata) during acclimation to local irradiance. We aimed to determine whether this is a general pattern among plant species with contrasting growth habits. METHODS: We compared observed relationships between leaf minor vein density, stomatal density, epidermal cell size and leaf size in four pairs of herbs and woody species from the same families grown under sun and shade conditions with modelled relationships assuming vein and stomatal densities respond passively to epidermal cell expansion...
August 29, 2016: Annals of Botany
Marion Taine, Bénédicte Stengel, Anne Forhan, Sophie Carles, Jérémie Botton, Marie-Aline Charles, Barbara Heude
Physiological evidence suggests that birth weight (BW) and postnatal growth affect blood pressure (BP) level, independently or in interaction. Their respective roles are difficult to disentangle in epidemiological studies, however, especially when adjusting for final weight. We assessed the portion of the effect of BW on BP at 5 years that was not attributable to postnatal growth and investigated potential interactions between BW and postnatal growth velocity at different time points in the EDEN mother-child study...
October 2016: Hypertension
Ximena Gaete, Patricia López, Nancy Unanue, Ethel Codner, Gabriel Cavada, Verónica Mericq
BACKGROUND: Menarche is the last stage of pubertal development, which coincides, with the completion of longitudinal growth. Our aim was to evaluate, post-menarcheal growth and clinical variables proposed to be associated with this growth. METHODS: In a prospective fashion, 106 healthy girls attending five different socioeconomic status (SES) schools of Santiago were randomly recruited. A pediatric endocrinologist obtained anthropometrics and registration of date at menarche every 6 months...
September 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Yanli Liu, Lihui Zhi, Jing Shen, Shizhao Li, Junhu Yao, Xiaojun Yang
BACKGROUND: Insulin-like factor 2 (IGF2) plays an important role in embryonic growth process by modulating intermediary metabolism and cell proliferation. Folic acid is involved in one carbon metabolism and contributes to DNA methylation which is related to gene expression. The purpose of this study was to explore whether folic acid could regulate IGF2 expression via epigenetic mechanism and further promote embryonic growth of new-hatched broilers. METHODS: In the present study, 360 fertile eggs were selected and randomly assigned to four treatments...
2016: Journal of Animal Science and Biotechnology
Dominique T Monteil, Valentin Juvet, Jonathan Paz, Marc Moniatte, Lucia Baldi, David L Hacker, Florian M Wurm
Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer rate. In the present study a Chinese hamster ovary (CHO) cell line producing a recombinant antibody was cultivated in a 5-L OSR and a 3-L STR, both operated with or without pH control. Effects of bioreactor type and pH control on cell growth and metabolism and on recombinant protein production and glycosylation were determined...
July 25, 2016: Biotechnology Progress
Magdalena Zuk, Magdalena Działo, Dorota Richter, Lucyna Dymińska, Jan Matuła, Andrzej Kotecki, Jerzy Hanuza, Jan Szopa
The chalcone synthase (CHS) gene controls the first step in the flavonoid biosynthesis. In flax, CHS down-regulation resulted in tannin accumulation and reduction in lignin synthesis, but plant growth was not affected. This suggests that lignin content and thus cell wall characteristics might be modulated through CHS activity. This study investigated the possibility that CHS affects cell wall sensing as well as polymer content and arrangement. CHS-suppressed and thus lignin-reduced plants showed significant changes in expression of genes involved in both synthesis of components and cell wall sensing...
2016: Frontiers in Plant Science
Natsumi Taniyama, Nobuto Kaneko, Yu Inatani, Yasuyuki Miyakoshi, Munetaka Shimizu
Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1 and RNA/DNA ratio are endocrine and biochemical parameters used as growth indices in fish, however, they are subjected to environmental modulation. Chum salmon (Oncorhynchus keta) migrate from freshwater (FW) to seawater (SW) at fry/juvenile stage weighing around 1g and suffer growth-dependent mortality during the early phase of their marine life. In order to reveal environmental modulation of the IGF/IGFBP system and establish a reliable growth index for juvenile chum salmon, we examined effects of SW transfer and fasting on IGF-I, IGFBP-1 and RNA/DNA ratio, and correlated them to individual growth rate...
September 15, 2016: General and Comparative Endocrinology
Young Ho Yun, Young Ae Kim, Jin Ah Sim, Ae Sun Shin, Yoon Jung Chang, Jongmog Lee, Moon Soo Kim, Young Mog Shim, Jae Lll Zo
BACKGROUND: We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS: We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), the Quality of Life Questionnaire Lung Cancer Module (QLQ-LC13), Hospital Anxiety and Depression Scale (HADS), and Posttraumatic Growth Inventory (PTGI) to 809 survivors who were surgically-treated for lung cancer at two hospitals from 2001 through 2006...
2016: BMC Cancer
Silvana Sandri, Fernanda Faião-Flores, Manoela Tiago, Paula Comune Pennacchi, Renato Ramos Massaro, Débora Kristina Alves-Fernandes, Gustavo Noriz Berardinelli, Adriane Feijó Evangelista, Vinicius de Lima Vazquez, Rui Manuel Reis, Silvya Stuchi Maria-Engler
The BRAF(V600E) mutation confers constitutive kinase activity and accounts for >90% of BRAF mutations in melanoma. This genetic alteration is a current therapeutic target; however, the antitumorigenic effects of the BRAF(V600E) inhibitor vemurafenib are short-lived and the majority of patients present tumor relapse in a short period after treatment. Characterization of vemurafenib resistance has been essential to the efficacy of next generation therapeutic strategies. Herein, we found that acute BRAF inhibition induced a decrease in active MMP-2, MT1-MMP and MMP-9, but did not modulate the metalloproteinase inhibitors TIMP-2 or RECK in naïve melanoma cells...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
André L Bombeiro, Júlio C Santini, Rodolfo Thomé, Elisângela R L Ferreira, Sérgio L O Nunes, Bárbara M Moreira, Ivan J M Bonet, Cesar R Sartori, Liana Verinaud, Alexandre L R Oliveira
Injuries to peripheral nerves cause loss of motor and sensory function, greatly affecting life quality. Successful repair of the lesioned nerve requires efficient cell debris removal, followed by axon regeneration and reinnervation of target organs. Such process is orchestrated by several cellular and molecular events in which glial and immune cells actively participate. It is known that tissue clearance is largely improved by macrophages, which activation is potentiated by cells and molecules of the acquired immune system, such as T helper lymphocytes and antibodies, respectively...
2016: Frontiers in Cellular Neuroscience
Kaituo Wang, Yunxia Liao, Qi Xiong, Jianquan Kan, Shifeng Cao, Yonghua Zheng
The specific forms of disease resistance induced by β-aminobutyric acid (BABA) and their impacts on sucrose metabolism of postharvest strawberries were determined in the present research. Treatment with 10-500 mmol L(-1) BABA inhibited the Botrytis cinerea infection, possibly directly by suppressing the fungus growth and indirectly by triggering disease resistance. Moreover, BABA-induced resistance against B. cinerea infection in strawberries was associated with either one of two mechanisms, depending upon the concentration used: BABA at concentrations higher than 100 mmol L(-1) directly induced the defense response, including a H2O2 burst, modulation of the expression of PR genes, including FaPR1, FaChi3, Faβglu, and FaPAL, and increased activities of chitinase, β-1,3-glucanase, and PAL, whereas BABA at 10 mmol L(-1) activated a priming response because the BABA-treated fruits exhibited an increased capacity to express molecular defense only when the fruits were inoculated with B...
July 27, 2016: Journal of Agricultural and Food Chemistry
Nicholas C Hoffend, William J Magner, Thomas B Tomasi
MicroRNAs (miRs) are small non-coding RNAs that regulate most cellular protein networks by targeting mRNAs for translational inhibition or degradation. Dicer, a type III endoribonuclease, is a critical component in microRNA biogenesis and is required for mature microRNA production. Abnormal Dicer expression occurs in numerous cancer types and correlates with poor patient prognosis. For example, increased Dicer expression in melanoma is associated with more aggressive tumors (higher tumor mitotic index and depth of invasion) and poor patient prognosis...
June 23, 2016: Oncotarget
Shyama Pal, Poonam Yadav, K B Sainis, Bhavani S Shankar
The mechanism by which tumor microenvironment derived cytokine network modulates therapy response is of great concern in lung cancer but is not completely understood. In this study, we evaluated the effects of tumor necrosis factor α (TNF-α) and insulin-like growth factor 1 (IGF-1) on response of lung cancer cell lines to ionizing radiation (IR). While TNF-α increased radio sensitivity and inhibited cell migration, treatment with IGF-1 promoted cell growth and increased migration. These effects of TNF- α were mediated by increased immediate activation of stress-activated protein kinases (SAPK)/jun amino-terminal kinases (JNK) and p38...
June 22, 2016: Cytokine
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