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https://www.readbyqxmd.com/read/28625568/the-olive-oil-phenolic-oleocanthal-modulates-estrogen-receptor-expression-in-luminal-breast-cancer-in-vitro-and-in-vivo-and-synergizes-with-tamoxifen-treatment
#1
Nehad M Ayoub, Abu Bakar Siddique, Hassan Y Ebrahim, Mohamed M Mohyeldin, Khalid A El Sayed
Luminal breast cancer represents a therapeutic challenge in terms of aggressive disease and emerging resistance to targeted therapy. (-)-Oleocanthal has demonstrated anticancer activity in multiple human cancers. The goal of this study was to explore the effect of (-)-oleocanthal treatment on growth of luminal breast cancer cells and to examine the effect of combination of (-)-oleocanthal with tamoxifen. Results showed that (-)-oleocanthal inhibited growth of BT-474, MCF-7, and T-47D human breast cancer cells in mitogen-free media with IC50 values of 32...
June 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28569122/rationale-and-design-of-combination-of-an-immune-modulator-fingolimod-with-alteplase-bridging-with-mechanical-thrombectomy-in-acute-ischemic-stroke-famtais-trial
#2
Sheng Zhang, Ying Zhou, Ruiting Zhang, Meixia Zhang, Bruce Campbell, Longting Lin, Fu-Dong Shi, Min Lou
Rationale In acute ischemic stroke patients with large vessel occlusion, although reperfusion within 6 h after stroke onset using combined intravenous alteplase and mechanical thrombectomy (bridging therapy) can improve functional outcome, still approximately 50% patients suffer disability which may result from reperfusion injury. Proof-of-concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in acute ischemic stroke patients as a single therapy beyond 4...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28555681/monitoring-of-bacterial-film-formation-and-its-breakdown-with-an-angular-based-surface-plasmon-resonance-biosensor
#3
Sandrine Filion-Côté, Feriel Melaine, Andrew G Kirk, Maryam Tabrizian
Bacterial biofilms are a leading cause of infection in health-care settings. Surface plasmon resonance (SPR) biosensors stand as valuable tools not only for the detection of biological entities and the characterisation of biomaterials but also as a suitable means to monitor bacterial film formation. This article reports on a proof-of-concept study for the use of an angular-based SPR biosensor for the monitoring of bacterial cell growth and biofilm formation and removal under the effect of different cleaning agents...
May 30, 2017: Analyst
https://www.readbyqxmd.com/read/28549792/endocannabinoids-modulate-apoptosis-in-endometriosis-and-adenomyosis
#4
Elif Bilgic, Elif Guzel Meydanli, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusuz
Adenomyosis that is a form of endometriosis is the growth of ectopic endometrial tissue within the muscular wall of the uterus (myometrium), which may cause dysmenorrhea and infertility. Endocannabinoid mediated apoptotic mechanisms of endometriosis and adenomyosis are not known. We hypothesized that the down regulation of endocannabinoid receptors and/or alteration in their regulatory enzymes may have a direct role in the pathogenesis of endometriosis and adenomyosis through apoptosis. Endocannabinoid receptors CB1 and CB2, their synthesizing and catabolizing enzymes (FAAH, NAPE-PLD, DAGL, MAGL) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues...
May 23, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28511728/birth-weight-interacts-with-a-functional-variant-of-the-oxytocin-receptor-gene-oxtr-to-predict-executive-functioning-in-children
#5
Mark Wade, Heather Prime, Thomas J Hoffmann, Louis A Schmidt, Thomas G O'Connor, Jennifer M Jenkins
Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children...
May 17, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28504713/elevated-pttg-and-pbf-predicts-poor-patient-outcome-and-modulates-dna-damage-response-genes-in-thyroid-cancer
#6
M L Read, J C Fong, B Modasia, A Fletcher, W Imruetaicharoenchoke, R J Thompson, H Nieto, J J Reynolds, A Bacon, U Mallick, A Hackshaw, J C Watkinson, K Boelaert, A S Turnell, V E Smith, C J McCabe
The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple cancer types, particularly thyroid and colorectal, but their combined role in tumourigenesis is uncharacterised. Here, we show for the first time that together PTTG and PBF significantly modulate DNA damage response (DDR) genes, including p53 target genes, required to maintain genomic integrity in thyroid cells. Critically, DDR genes were extensively repressed in primary thyrocytes from a bitransgenic murine model (Bi-Tg) of thyroid-specific PBF and PTTG overexpression...
May 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28494385/l-leucine-dietary-supplementation-modulates-muscle-protein-degradation-and-increases-pro-inflammatory-cytokines-in-tumour-bearing-rats
#7
Bread Cruz, André Oliveira, Maria Cristina Cintra Gomes-Marcondes
Cancer cachexia is characterised by involuntary weight loss associated with systemic inflammation and metabolic changes. Studies aimed at maintaining lean body mass in cachectic tumour-bearing hosts have made important contributions reducing the number of deaths and improving the quality of life. In recent years, leucine has demonstrated effective action in maintaining lean body mass by decreasing muscle protein degradation. Currently, there is a growing need to understand how leucine stimulates protein synthesis and acts protectively in a cachectic organism...
May 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28487275/a-phenome-database-neauhlfpd-designed-and-constructed-for-broiler-lines-divergently-selected-for-abdominal-fat-content
#8
Li Min, Dong Xiangyu, Liang Hao, Leng Li, Zhang Hui, Wang Shouzhi, Li Hui, Du Zhi-Qiang
Effective management and analysis of precisely recorded phenotypic traits are important components of the selection and breeding of superior livestocks. Over two decades, we divergently selected chicken lines for abdominal fat content at Northeast Agricultural University (Northeast Agricultural University High and Low Fat, NEAUHLF), and collected large volume of phenotypic data related to the investigation on molecular genetic basis of adipose tissue deposition in broilers. To effectively and systematically store, manage and analyze phenotypic data, we built the NEAUHLF Phenome Database (NEAUHLFPD)...
May 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28484274/monocytic-microrna-profile-associated-with-coronary-collateral-artery-function-in-chronic-total-occlusion-patients
#9
Nazanin Hakimzadeh, Joëlle Elias, Gilbert W M Wijntjens, Ruud Theunissen, Angela van Weert, Martijn W Smulders, Nynke van den Akker, Perry D Moerland, Hein J Verberne, Loes P Hoebers, Jose P S Henriques, Anja M van der Laan, Mustafa Ilhan, Mark Post, Sebastiaan C A M Bekkers, Jan J Piek
An expansive collateral artery network is correlated with improved survival in case of adverse cardiac episodes. We aimed to identify cellular microRNAs (miRNA; miR) important for collateral artery growth. Chronic total occlusion (CTO) patients (n = 26) were dichotomized using pressure-derived collateral flow index (CFIp) measurements; high collateral capacity (CFIp > 0.39; n = 14) and low collateral (CFIp < 0.39; n = 12) capacity. MiRNA profiling via next generation sequencing from various monocyte phenotypes (freshly isolated monocytes, monocytes cultured without stimulant, or stimulation with lipopolysaccharide, interleukin 4, transforming growth factor beta-1, or interferon gamma) revealed significantly different miRNA expression patterns between high versus low collateral capacity patients...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28459020/disruption-of-angiogenesis-by-anthocyanin-rich-extracts-of-hibiscus-sabdariffa
#10
Madu Joshua, Christiana Okere, O'Donnell Sylvester, Muhammad Yahaya, Omale Precious, Thagriki Dluya, Ji-Yeon Um, Musa Neksumi, Jessica Boyd, Jennifer Vincent-Tyndall, Dong-Won Choo, Diana R Gutsaeva, Wan Jin Jahng
Abnormal vessel formations contribute to the progression of specific angiogenic diseases including age-related macular degeneration. Adequate vessel growth and maintenance represent the coordinated process of endothelial cell proliferation, matrix remodeling, and differentiation. However, the molecular mechanism of the proper balance between angiogenic activators and inhibitors remains elusive. In addition, quantitative analysis of vessel formation has been challenging due to complex angiogenic morphology. We hypothesized that conjugated double bond containing-natural products, including anthocyanin extracts from Hibiscus sabdariffa, may control the proper angiogenesis...
February 2017: International Journal of Scientific and Engineering Research
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#11
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28431534/the-effects-of-spirulina-platensis-on-anthropometric-indices-appetite-lipid-profile-and-serum-vascular-endothelial-growth-factor-vegf-in-obese-individuals-a-randomized-double-blinded-placebo-controlled-trial
#12
Reihaneh Zeinalian, Mahdieh Abbasalizad Farhangi, Atefeh Shariat, Maryam Saghafi-Asl
BACKGROUND: In recent years, a great attention has been focused on Spirulina platensis as a source of potential valuable nutrients for prevention and treatment of chronic diseases. The objectives of the current study were to determine the effects of Spirulina platensis on anthropometric parameters, serum lipids, appetite and serum Vascular Endothelial Growth Factor (VEGF) in obese individuals. METHODS: In the current study sixty four obese individuals aged 20-50 years were enrolled and randomly allocated into two groups of intervention and placebo...
April 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28415766/anti-proliferative-role-of-recombinant-lethal-toxin-of-bacillus-anthracis-on-primary-mammary-ductal-carcinoma-cells-revealing-its-therapeutic-potential
#13
Rekha Khandia, Bramhadev Pattnaik, Katherukamem Rajukumar, Atul Pateriya, Sandeep Bhatia, Harshad Murugkar, Anil Prakash, Hare Krishna Pradhan, Kuldeep Dhama, Ashok Munjal, Sunil K Joshi
Bacillus anthracis secretes three secretary proteins; lethal factor (LF), protective antigen (PA) and edema factor (EF). The LF has ability to check proliferation of mammary tumors, chiefly depending on mitogen activated protein kinase (MAPK) signaling pathway. Evaluation of therapeutic potential of recombinant LF (rLF), recombinant PA (rPA) and lethal toxin (rLF + rPA = LeTx) on the primary mammary ductal carcinoma cells revealed significant (p < 0.01) reduction in proliferation of tumor cells with mean inhibition indices of 28...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386902/effect-of-earthworms-on-growth-photosynthetic-efficiency-and-metal-uptake-in-brassica-juncea-l-plants-grown-in-cadmium-polluted-soils
#14
Parminder Kaur, Shagun Bali, Anket Sharma, Adarsh Pal Vig, Renu Bhardwaj
The present study has been carried out to examine the role of earthworms in phytoremediation of Cd and its effect on growth, pigment content, expression of genes coding key enzymes of pigments, photosynthetic efficiency and osmoprotectants in Brassica juncea L. plants grown under cadmium (Cd) metal stress. The effect of different Cd concentrations (0.50, 0.75, 1.0, 1.25 mM) was studied in 30 and 60-day-old plants grown in soils containing earthworms. It was observed that earthworm inoculation showed stimulatory effect on phytoremediation capacity and Cd uptake has increased by 49% (in 30-day-old plants) and 35% (in 60-day-old plants) in shoots and 13...
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28375968/curve-modulation-and-apex-migration-using-shilla-growth-guidance-rods-for-early-onset-scoliosis-at-5-year-follow-up
#15
John T Wilkinson, Chad E Songy, David B Bumpass, Francis L McCullough, Richard E McCarthy
BACKGROUND: The Shilla procedure was designed to correct and control early-onset spinal deformity while harnessing a child's remaining spinal growth. It allows for controlled axial skeletal growth within the construct, avoiding the need for frequent surgeries to lengthen implants. We hypothesized that curve characteristics evolve over time after initial apex fusion and placement of the Shilla implants. The purpose of this study was to identify trends in curve evolution after Shilla implantation and understand how these changes influence ultimate outcome...
April 3, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28359360/postprandial-changes-in-glucose-oxidation-and-insulin-sensitivity-in-metabolic-syndrome-influence-of-fibroblast-growth-factor-21-and-vitamin-d-status
#16
Kaveri Pathak, Mario J Soares, Yun Zhao, Anthony P James, Jillian L Sherriff, Philip Newsholme
OBJECTIVE: Metabolic inflexibility due to insulin resistance has been reported in metabolic syndrome (MetS). Fibroblast growth factor 21 (FGF21) and vitamin D status may improve insulin sensitivity. The aim of this study was to investigate glucose-induced thermogenesis and oxidation in MetS, and to examine whether changes in FGF21 or prevailing vitamin D status modulated defined metabolic parameters. METHODS: Forty-eight overweight and obese older adults (14 men, 34 women; ages 51 ± 15 y) were studied...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28337744/tknockdown-of-an-inflorescence-meristem-specific-cytokinin-oxidase-osckx2-in-rice-reduces-yield-penalty-under-salinity-stress-condition
#17
Rohit Joshi, Khirod Kumar Sahoo, Amit Kumar Tripathi, Ritesh Kumar, Brijesh Kumar Gupta, Ashwani Pareek, Sneh Lata Singla-Pareek
Cytokinins play a significant role in determining grain yield in plants. Cytokinin oxidases catalyze irreversible degradation of cytokinins and hence modulate cellular cytokinin levels. Here, we studied the role of an inflorescence meristem-specific rice cytokinin oxidase - OsCKX2, in reducing yield penalty under salinity stress conditions. We utilized an RNAi-based approach to study the function of OsCKX2 in maintaining grain yield under salinity stress condition. Ultra-performance liquid chromatography (UPLC)-based estimation revealed a significant increase in cytokinins in the inflorescence meristem of OsCKX2-knockdown plants...
March 24, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28323284/altered-peripheral-immune-profiles-in-treatment-resistant-depression-response-to-ketamine-and-prediction-of-treatment-outcome
#18
D D Kiraly, S R Horn, N T Van Dam, S Costi, J Schwartz, S Kim-Schulze, M Patel, G E Hodes, S J Russo, M Merad, D V Iosifescu, D S Charney, J W Murrough
A subset of patients with depression have elevated levels of inflammatory cytokines, and some studies demonstrate interaction between inflammatory factors and treatment outcome. However, most studies focus on only a narrow subset of factors in a patient sample. In the current study, we analyzed broad immune profiles in blood from patients with treatment-resistant depression (TRD) at baseline and following treatment with the glutamate modulator ketamine. Serum was analyzed from 26 healthy control and 33 actively depressed TRD patients free of antidepressant medication, and matched for age, sex and body mass index...
March 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28290079/silicon-alleviates-salt-and-drought-stress-of-glycyrrhiza-uralensis-seedling-by-altering-antioxidant-metabolism-and-osmotic-adjustment
#19
Wenjin Zhang, Zhicai Xie, Lianhong Wang, Ming Li, Duoyong Lang, Xinhui Zhang
This study was conducted to determine effect and mechanism of exogenous silicon (Si) on salt and drought tolerance of Glycyrrhiza uralensis seedling by focusing on the pathways of antioxidant defense and osmotic adjustment. Seedling growth, lipid peroxidation, antioxidant metabolism, osmolytes concentration and Si content of G. uralensis seedlings were analyzed under control, salt and drought stress [100 mM NaCl with 0, 10 and 20% of PEG-6000 (Polyethylene glycol-6000)] with or without 1 mM Si. Si addition markedly affected the G...
March 13, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28286419/dual-roles-of-extracellular-signal-regulated-kinase-erk-in-quinoline-compound-bpiq-induced-apoptosis-and-anti-migration-of-human-non-small-cell-lung-cancer-cells
#20
Yao Fong, Chang-Yi Wu, Kuo-Feng Chang, Bing-Hung Chen, Wan-Ju Chou, Chih-Hua Tseng, Yen-Chun Chen, Hui-Min David Wang, Yeh-Long Chen, Chien-Chih Chiu
BACKGROUND: 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ through modulating mitochondrial-mediated apoptosis. However, the effect of BPIQ on cell migration, an index of cancer metastasis, has not yet been examined. Furthermore, among signal pathways involved in stresses, the members of the mitogen-activated protein kinase (MAPK) family are crucial for regulating the survival and migration of cells...
2017: Cancer Cell International
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