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Lichen planopilaris

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https://www.readbyqxmd.com/read/29141063/novel-treatment-using-low-dose-naltrexone-for-lichen-planopilaris
#1
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
<p>Lichen planopilaris (LPP) is a variant of lichen planus that affects the scalp causing scarring hair loss. Patients also frequently experience symptoms of scalp itch, pain, and burning. To date, there are no long-term remittive nor curative therapies available. Low-dose naltrexone has anti-inflammatory properties and has recently been described in the context of treating autoimmune conditions. This retrospective medical record review describes four LPP patients treated with low-dose (3 milligrams per day) naltrexone...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29106928/epithelial-mesenchymal-stem-cell-transition-in-a-human-organ-lessons-from-lichen-planopilaris
#2
H Imanishi, D M Ansell, J Chéret, M Harries, M Bertolini, N Sepp, T Bíró, E Poblet, F Jimenez, J Hardman, S Parameswara Panicker, C M Ward, R Paus
Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles (HFs), during the inflammatory permanent alopecia, lichen planopilaris (LPP). We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with TGF-ß1, EGF, and interferon-γ administration, which to our knowledge is previously unreported...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29056083/frontal-fibrosing-alopecia-update-and-review-of-challenges-and-successes
#3
Derek To, Jennifer Beecker
BACKGROUND: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris (LPP) and is characterised as a progressive cicatricial alopecia affecting the frontotemporal hairline. OBJECTIVES: To perform a comprehensive, up-to-date review of the etiopathogenesis, clinicopathological features, and therapeutic options for FFA. METHODS: A literature search was conducted using PubMed (from 1946) and Cochrane (from 1991) databases on March 7, 2017...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28954108/lichen-planopilaris-developed-during-childhood
#4
Heliana Freitas de Oliveira Góes, Maria Fernanda Reis Gavazzoni Dias, Simone de Abreu Neves Salles, Caren Dos Santos Lima, Müller da Silva Vieira, Luciana Pantaleão
Lichen planopilaris is a disease that appears with lymphocytic cicatricial alopecia. It is considered a follicular variant of lichen planus. The examination of affected areas shows alopecia with perifollicular erythema and scaling, revealing a predilection for hair follicles. The involvement of children is uncommon, with few reports in this population in the literature. This study presents a clinical case of a male patient of 15 years of age with characteristic lesions of lichen planopilaris.
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28944688/treatment-of-lichen-planopilaris-methotrexate-or-cyclosporine-a-therapy
#5
Emel Bulbul Baskan, Serkan Yazici
BACKGROUND: Because of irreversible outcome of the lichen planopilaris (LPP), systemic therapy should be used in early inflammatory stages of the disease, without allowing the irreversible scar formation and permanent hair loss. OBJECTIVE: We assessed the efficacy and safety of methotrexate (MTX) and cyclosporine A (CsA) in the management of recalcitrant, extensive LPP and compared their efficacy and safety profile. METHODS: We retrospectively analysed the 16 LPP cases treated with either CsA or MTX therapy...
October 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28932068/familial-cicatricial-alopecia-report-of-familial-frontal-fibrosing-alopecia-and-fibrosing-alopecia-in-a-pattern-distribution
#6
Dandara Meurer Missio, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
Frontal fibrosing alopecia (FFA) and fibrosing alopecia in a pattern distribution (FAPD) as originally reported by Kossard in 1994 and by Zinkernagel and Trüeb in 2000, respectively, represent two distinct patterns of cicatricial pattern hair loss. Both share a patterned distribution and histological evidence of a lichenoid follicular inflammation with fibrosis. FFA is characterized by a marginal alopecia along the frontotemporal hairline, and FAPD by a progressive alopecia of the centroparietal scalp. Since the original reports, evidence has accumulated that there exists considerable clinical overlap among FFA, FAPD, and lichen planopilaris, with coexistence of features of the three conditions within the same individual...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932062/primary-idiopathic-pseudopelade-of-brocq-in-a-young-child
#7
Pragya Ashok Nair, Rochit Singhal, Kira Pariath
Pseudopelade of Brocq (PPB) is a rare, chronic, slowly progressive cicatricial alopecia that generally affects middle-aged women. Vertex and parietal scalp are commonly involved. It can be primary or secondary to end stage of other scarring alopecia such as lichen planopilaris and discoid lupus erythematosus. It is diagnosed by exclusion both clinically and trichoscopy. There is no standard treatment for PPB. We hereby report a case of rapidly progressing primary idiopathic pseudopelade of Brocq in a young female child confirmed by trichoscopy and histopathology...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28879190/primary-scarring-alopecia-clinical-pathological-review-of-72-cases-and-review-of-the-literature
#8
Salvador Villablanca, Cristián Fischer, S Cecilia García-García, J Manuel Mascaró-Galy, Juan Ferrando
PURPOSE OF THE STUDY: To analyze the epidemiologic, demographic, clinical, and histological characteristics of primary scarring alopecia (PSA) cases diagnosed over a 7-year period at the Department of Dermatology, Hospital Clinic, Barcelona, Spain. PROCEDURES: Seventy-two patients diagnosed with PSA between 2006 and 2012 were included. Age, sex, ethnic group, clinical pattern, predominant histological infiltrate, final clinical diagnosis, time of onset, treatments used, and clinical evolution were evaluated and correlated...
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28879188/the-use-of-direct-immunofluorescence-in-frontal-fibrosing-alopecia
#9
Aline Donati, Aditya K Gupta, Carolina Jacob, Benedicte Cavelier-Balloy, Pascal Reygagne
BACKGROUND: Frontal fibrosing alopecia (FFA) differs from lichen planopilaris (LPP) in many clinical aspects, but histology fails to distinguish between these entities. Direct immunofluorescence (DIF) is a diagnostic technique used for autoimmune diseases, including those affecting skin and hair. OBJECTIVE: To characterize DIF patterns in patients with FFA. METHOD: Data was collected retrospectively from FFA cases presenting to the Centre de Santé Sabouraud Hair Clinic in Paris from November 2013 to November 2014...
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28839393/invisible-lichen-planopilaris-unmasked-by-dermatoscopy
#10
Balakrishnan Nirmal, Renu George, Thomas Alex Kodiatte
Lichen planopilaris is a form of lymphocyte-mediated primary cicatricial alopecia characterized by perifollicular scaling progressing to patches of alopecia depending on the clinical variant. The course is relentlessly progressive and chronic. Hence, early diagnosis and institution of therapy are imperative to halt the disease progress. Although definitive diagnosis is made by scalp biopsy, the detection is usually delayed. Dermatoscopy helps in early recognition of this condition which at that stage is clinically invisible...
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28816743/elastic-staining-in-differentiating-between-follicular-streamers-and-follicular-scars-in-horizontal-scalp-biopsy-sections
#11
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. METHODS: Sixty-four cicatricial alopecias (25 lichen planopilaris, 29 central centrifugal cicatricial alopecias, and 10 discoid lupus erythematosus) and 53 noncicatricial alopecias (34 androgenic alopecia, 8 telogen effluvium, and 11 alopecia areata) were identified, and EVG staining was performed on horizontal sections...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28748570/lichen-planopilaris-in-a-latin-american-chilean-population-demographics-clinical-profile-and-treatment-experience
#12
F Mardones, J Shapiro
BACKGROUND: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. METHODS: This was a retrospective review of medical records and clinical follow-up of Chilean adults with a clinical and histopathological diagnosis of LPP...
October 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28736812/hair-transplantation-for-the-treatment-of-lichen-planopilaris-and-frontal-fibrosing-alopecia-a-report-of-two-cases
#13
You-Chen Serena Liu, Shiou-Hwa Jee, Jung-Yi Lisa Chan
The efficacy of current medical treatments for lichen planopilaris (LPP) and its variant, frontal fibrosing alopecia (FFA), both lymphocyte-mediated primary cicatricial alopecias, is limited. Hair regrowth from scar tissue is usually not possible. Although hair transplantation restores the hairline and increases hair density in patients with cicatricial alopecia, the timing of the transplantation is crucial. Here, we report two Chinese patients with LPP or FFA who underwent the follicular unit extraction method of hair transplantation after the diseases were stabilised with therapy, with satisfactory results for 3-4 years of follow up...
July 24, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#14
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28584619/clinical-efficacy-and-safety-of-methotrexate-versus-hydroxychloroquine-in-preventing-lichen-planopilaris-progress-a-randomized-clinical-trial
#15
Farahnaz Fatemi Naeini, Mina Saber, Ali Asilian, Sayed Mohsen Hosseini
BACKGROUND: Lichen planopilaris is an inflammatory cicatricial alopecia, and its management is a challenge for dermatologists. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. METHODS: In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day for 6 months. Side effects, symptoms/signs, and laboratory tests were assessed periodically...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28522040/the-depth-of-inflammation-in-frontal-fibrosing-alopecia-and-lichen-planopilaris-a-potential-distinguishing-feature
#16
COMPARATIVE STUDY
Denise Wong, Lynne J Goldberg
No abstract text is available yet for this article.
June 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28442883/a-comment-on-frontal-fibrosing-alopecia-axel-munthe-s-syndrome
#17
Ralph M Trüeb
Frontal fibrosing alopecia (FFA) represents a peculiar condition with a quasi-symmetrical, marginal alopecia along the frontal and temporal hairline with scarring. Steven Kossard is credited with the original description of the condition in 1994. Since its first description, FFA has become increasingly common while its etiology has remained obscure. While FFA has been related to lichen planopilaris, in fact, the pattern of clinical disease presentation might be more specific for the condition than the underlying inflammatory autoimmune reaction...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28442882/comparative-analysis-of-immunopathological-features-of-lichen-planopilaris-and-female-patients-with-frontal-fibrosing-alopecia
#18
Emanuella Rd Cerqueira, Neusa Valente, Mírian Nacagami Sotto, Ricardo Romiti
BACKGROUND: Frontal fibrosing alopecia (FFA) is a disorder characterized by progressive cicatricial alopecia (CA). Its classification as a clinical variant of lichen planopilaris (LPP) or as a unique disorder is controversial. The presence of Langerhans cells within the bulge area and the sebaceous epithelium and the presence of lymphocytic infiltrate in this area in CA have led to a series of hypotheses, although limited, about their development. To our knowledge, scarce is the literature demonstrating immunoanalytical studies comparing both disorders...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#19
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28329547/lichen-planus-pigmentosus-and-lichen-planopilaris
#20
Gabriela Cobos, Randie H Kim, Shane Meehan, Nada Elbuluk
Lichen planus is an inflammatory skin conditionwith characteristic histopathological findings thathas many clinical variants. Recently, there have been25 cases reported in the literature of lichen planuspigmentosus (LPPi) that preceded the developmentof frontal fibrosing alopecia (FFA), which is a variantof lichen planopilaris (LPP). We review the literatureregarding LPPi, LPP, and FFA and present a case of a40-year-old African American woman with LPPi andLPP.
December 15, 2016: Dermatology Online Journal
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