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https://www.readbyqxmd.com/read/28807720/comparison-of-the-therapeutic-effects-of-sildenafil-citrate-heparin-and-neuropeptides-in-a-rat-model-of-acetic-acid-induced-gastric-ulcer
#1
Mehmet Kalayci, Mehmet Ali Kocdor, Tuncay Kuloglu, İbrahim Sahin, Mehmet Sarac, Aziz Aksoy, Meltem Yardim, Semih Dalkilic, Onur Gursu, Suna Aydin, Ramazan Fazil Akkoc, Meltem Cokugras, Gokhan Artas, İbrahim Hanifi Ozercan, Kader Ugur, Suleyman Aydin
AIMS: The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS: The animals were divided into 13 groups, with 4 animals in each. Gastric ulcers was induced in the animals of 12 groups with one untreated group being left as the control (Group I - control; given normal saline (NS))...
August 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28796641/the-effect-of-thyroid-dysfunction-on-nesfatin-1-and-adiponectin-levels-in-rats
#2
Emine Atıcı, Rasim Mogulkoc, Abdulkerim Kasım Baltacı, Esma Menevse
Background Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1...
August 10, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28795473/gastrointestinal-peptides-during-chronic-gastric-electrical-stimulation-in-patients-with-intractable-vomiting
#3
Mathieu Meleine, Chloé Melchior, Philip Prinz, Alfred Penfornis, Benoît Coffin, Andreas Stengel, Philippe Ducrotté, Guillaume Gourcerol
OBJECTIVES: Gastric electrical stimulation (GES) is an alternative therapy to treat patients with intractable vomiting. A preclinical study has demonstrated the modulation of the gastrointestinal (GI) peptide ghrelin by GES but such mechanism has never been investigated in patients. The aim of this work was to assess the effect of GES on GI peptide levels in patients with intractable vomiting. MATERIALS AND METHODS: Twenty-one patients were randomized to receive either ON or OFF GES, 14 completed the study (10 ON, 4 OFF stimulation)...
August 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28762571/sex-specific-differences-in-cardiovascular-and-metabolic-hormones-with-integrated-signalling-in-the-paraventricular-nucleus-of-the-hypothalamus
#4
Spencer P Loewen, Alex R Paterson, Su Yi Loh, Mark F Rogers, Charles C T Hindmarch, David Murphy, Alastair V Ferguson
Many traditional cardiovascular hormones have been implicated in metabolic function. Conversely, many hormones traditionally involved in metabolic regulation have an effect on cardiovascular function. Many of these signalling molecules exert such effects through specific actions in the paraventricular nucleus (PVN), an integrative autonomic control centre located in the hypothalamus. Here, we focus on four cardiovascular/metabolic peptide hormones that signal within the PVN, angiotensin II, orexin, adiponectin, and nesfatin-1...
August 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28739555/serum-nesfatin-1-levels-in-girls-with-idiopathic-central-precocious-puberty
#5
Ayça Altıncık, Oya Sayın
OBJECTIVE: Nesfatin-1, which is defined as an anorexigenic neuropeptide, is expressed mainly in central nervous system and in some periferic tissues. The role of nesfatin-1 in energy balance has been investigated; however, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty; and ii) relationship between nesfatin-1 and anthropometric measures, gonadotropin levels in girls with idiopathic central precocious puberty (CPP)...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28720397/cardioprotective-effect-of-nesfatin-1-against-isoproterenol-induced-myocardial-infarction-in-rats-role-of-the-akt-gsk-3%C3%AE-pathway
#6
Arda Tasatargil, Nilay Kuscu, Selvinaz Dalaklioglu, Dileyra Adiguzel, Ciler Celik-Ozenci, Sebahat Ozdem, Ayse Barutcigil, Sadi Ozdem
The present study was designed to evaluate the cardioprotective effects of nesfatin-1, a novel peptide with anorexigenic properties, in rats with isoproterenol (ISO)-induced myocardial infarction (MI), and to further investigate the role of Akt/GSK-3β signaling pathway in the protective effect of nesfatin-1. To induce MI, ISO was subcutaneously injected into the rats for two consecutive days at a dosage of 85mg/kg/day. ISO-induced myocardial damage was indicated by elevated levels of cardiac specific troponin-T, enhanced myocardial expression of proinflammatory cytokines (interleukin-1β, interleukin-6 and tumor necrosis factor-α), and increased number of cells with apoptotic and necrotic appearance in the myocardial tissue...
July 15, 2017: Peptides
https://www.readbyqxmd.com/read/28717234/dietary-lipid-content-reorganizes-gut-microbiota-and-probiotic-l-rhamnosus-attenuates-obesity-and-enhances-catabolic-hormonal-milieu-in-zebrafish
#7
Silvia Falcinelli, Ana Rodiles, Azadeh Hatef, Simona Picchietti, Lina Cossignani, Daniel L Merrifield, Suraj Unniappan, Oliana Carnevali
In the present study, we explored whether dietary lipid content influences the gut microbiome in adult zebrafish. Diets containing three different lipid levels (high [HFD], medium [MFD], and low [LFD]) were administered with or without the supplementation of Lactobacillus rhamnosus (P) to zebrafish in order to explore how the dietary lipid content may influence the gut microbiome. Dietary lipid content shifted the gut microbiome structure. The addition of L. rhamnosus in the diets, induced transcriptional reduction of orexigenic genes, upregulation of anorexigenic genes, and transcriptional decrease of genes involved in cholesterol and triglyceride (TAG) metabolism, concomitantly with lower content of cholesterol and TAG...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698350/efficacy-of-nanocurcumin-supplementation-on-insulin-resistance-lipids-inflammatory-factors-and-nesfatin-among-obese-patients-with-non-alcoholic-fatty-liver-disease-nafld-a-trial-protocol
#8
Seyed Ali Jazayeri-Tehrani, Seyed Mahdi Rezayat, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Milad Daneshi-Maskooni, Mohammad-Javad Hosseinzadeh-Attar
OBJECTIVES: Different studies have been conducted on the role of curcumin in health since having multiple properties, including antioxidant and anti-inflammatory effects. Due to the lack of studies regarding curcumin effects on obese patients with non-alcoholic fatty liver disease (NAFLD), our protocol was designed to assess nanocurcumin impacts on blood sugar, lipids, inflammatory indices, insulin resistance and liver function, especially by nesfatin. SETTING: This trial will be conducted in the Oil Company central hospital of Tehran, Iran with a primary level of care...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697955/nesfatin-1-inhibits-voltage-gated-k-channels-in-pancreatic-beta-cells
#9
Yuko Maejima, Shoichiro Horita, Daisuke Kobayashi, Miho Aoki, Rie O'hashi, Ryota Imai, Kazuho Sakamoto, Masatomo Mori, Katsuya Takasu, Kazuma Ogawa, Seiichi Takenoshita, Songji Zhao, Akihiro Hazama, Kenju Shimomura
The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation. In spite of the growing knowledge of its physiological functions through extensive studies, its molecular mechanism of reaction, including its receptor, remains unknown. NUCB2/nesfatin-1 is also involved in various peripheral regulations, including glucose homeostasis. In pancreatic beta-cells, NUCB2/nesfatin-1 is reported to enhance glucose-stimulated insulin secretion (GSIS) but its exact mechanism remains unknown...
July 8, 2017: Peptides
https://www.readbyqxmd.com/read/28694701/high-levels-of-nesfatin-1-in-relation-to-the-dysfunction-of-the-hypothalamic-pituitary-adrenal-and-hypothalamus-pituitary-thyroid-axes-in-depressed-patients-with-subclinical-hypothyroidism
#10
Ya-Yun Xu, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Qing-Rong Xia
Despite the increasing amount of evidence suggesting a relationship between depression and subclinical hypothyroidism (SCH), the exact mechanism underlying this relationship remains unclear. The main purpose of this study was to investigate the roles of plasma Nesfatin-1 levels and dysfunction of the hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes in the comorbidity of depression and SCH. Dysfunctions of the HPA and HPT axes were detected by measuring plasma corticosterone and thyroid-stimulating hormone (TSH) concentrations, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28691407/oxidative-stress-hepcidin-and-nesfatin-i-status-in-childhood-iron-and-vitamin-b12-deficiency-anemias
#11
Tünay Kontaş Aşkar, Olga Büyükleblebici, Adnan Adil Hismioğulları, Zeynep Hünkerler
BACKGROUND: Anemia is a disease that is long and often repetitive and can result in great burden to the national economy. The most frequent nutritional deficiency anemias in children are related with iron and vitamin B12 deficiencies. OBJECTIVES: The aim of this study was to determine the oxidative stress, hepcidin, and nesfatin-I levels in childhood iron and vitamin B12 deficiency anemias. MATERIAL AND METHODS: The study had three groups of 15 children, iron anemia deficiency group, vitamin B12 deficiency group and a control group...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28684238/involvement-of-central-nesfatin-1-neurons-on-oxytocin-induced-feeding-suppression-in-rats
#12
Reiko Saito, Satomi Sonoda, Hiromichi Ueno, Yasuhito Motojima, Mitsuhiro Yoshimura, Takashi Maruyama, Hirofumi Hashimoto, Kentaro Tanaka, Yukiyo Yamamoto, Koichi Kusuhara, Yoichi Ueta
Peripheral anorectic hormones, such as peptide YY (PYY) and oxytocin (OXT), suppress food intake. A newly identified anorectic neuropeptide, nesfatin-1, is synthesized in both peripheral tissue and the central nervous system, particularly by various nuclei in the hypothalamus and brainstem. Here, we examined the effects of intraperitoneal (ip) administration of PYY3-36, OXT, and OXT analog, on nesfatin-1-immunoreactive (ir) neurons in the rat hypothalamus and brainstem, using Fos double fluorescence-immunohistochemistry...
August 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28653126/impact-of-metabolic-hormones-secreted-in-human-breast-milk-on-nutritional-programming-in-childhood-obesity
#13
REVIEW
Pilar Amellali Badillo-Suárez, Maricela Rodríguez-Cruz, Xóchitl Nieves-Morales
Obesity is the most common metabolic disease whose prevalence is increasing worldwide. This condition is considered a serious public health problem due to associated comorbidities such as diabetes mellitus and hypertension. Perinatal morbidity related to obesity does not end with birth; this continues affecting the mother/infant binomial and could negatively impact on metabolism during early infant nutrition. Nutrition in early stages of growth may be essential in the development of obesity in adulthood, supporting the concept of "nutritional programming"...
June 27, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28645611/activation-of-central-nesfatin-1-nucb2-after-intraperitoneally-administered-cisplatin-in-rats
#14
Yasuki Akiyama, Mitsuhiro Yoshimura, Kazuaki Nishimura, Haruki Nishimura, Satomi Sonoda, Hiromichi Ueno, Yasuhito Mitojima, Reiko Saito, Takashi Maruyama, Yuki Nonaka, Hirofumi Hashimoto, Yasuhito Uezono, Keiji Hirata, Yoichi Ueta
Cisplatin, known as an anticancer drug, has been widely used; however, diverse disadvantageous side effects, including appetite loss, afflict patients. Nesfatin-1/NucB2, discovered as an anorexic neuropeptide, is broadly expressed in the central nervous system (CNS) and peripheral organ. In the present study, we examined the effects of intraperitoneally (i.p.) administered cisplatin on central nesfatin-1/NucB2. Saline, as control, or cisplatin (6 mg/kg dissolved in saline) was i.p. administered in adult male Wistar rats (180-220 g)...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28624500/phoenixin-14-concentrations-are-increased-in-association-with-luteinizing-hormone-and-nesfatin-1-concentrations-in-women-with-polycystic-ovary-syndrome
#15
Kamran Ullah, Tanzil Ur Rahman, Dan-Dan Wu, Xian-Hua Lin, Ye Liu, Xiao-Yan Guo, Peter C K Leung, Run-Ju Zhang, He-Feng Huang, Jian-Zhong Sheng
BACKGROUND: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients...
August 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28608000/crhr1-mediates-the-up-regulation-of-synapsin-i-induced-by-nesfatin-1-through-erk-1-2-signaling-in-sh-sy5y-cells
#16
Zheng Chen, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
The anorexigenic molecule nesfatin-1 has recently been taken as a potential mood regulator, but the potential mechanisms remain unknown. Results of our previous study have demonstrated that nesfatin-1 could induce anxiety- and depression-like behaviors in rats, accompanied by the hyperactivity of the hypothalamic-pituitary-adrenal axis and the imbalanced mRNA expression of synaptic vesicle proteins. To explore the potential neurobiological mechanism underlying the effect of nesfatin-1 on the synaptic plasticity, the human neuroblastoma SH-SY5Y cells were cultured and treated with different concentrations of nesfatin-1 in the present study...
June 12, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28552377/influence-of-water-salinity-on-genes-implicated-in-somatic-growth-lipid-metabolism-and-food-intake-in-pejerrey-odontesthes-bonariensis
#17
Juan Ignacio Bertucci, Mario Oswaldo Tovar, Ayelén Melisa Blanco, Pedro Gómez-Requeni, Suraj Unniappan, Luis Fabián Canosa
Pejerrey, Odontesthes bonariensis, is an euryhaline fish of commercial importance in Argentina. This work aimed to determine if water salinity affects the expression of genes involved in somatic growth (gh; ghr-I; ghr-II; igf-I), lipid metabolism (Δ6-desaturase) and food intake (nucb2/nesfatin-1). First, we identified the full-length cDNA sequences of Δ6-desaturase (involved in lipid metabolism) and nesfatin-1 (an anorexigen). Then, pejerrey juveniles were reared during 8weeks in three different water salinity conditions: 2...
August 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28542568/nesfatin-1-like-peptide-is-a-novel-metabolic-factor-that-suppresses-feeding-and-regulates-whole-body-energy-homeostasis-in-male-wistar-rats
#18
Kavishankar Gawli, Naresh Ramesh, Suraj Unniappan
Nucleobindin-1 has high sequence similarity to nucleobindin-2, which encodes the anorectic and metabolic peptide, nesfatin-1. We previously reported a nesfatin-1-like peptide (NLP), anorectic in fish and insulinotropic in mice islet beta-like cells. The main objective of this research was to determine whether NLP is a metabolic regulator in male Wistar rats. A single intraperitoneal (IP) injection of NLP (100 μg/kg BW) decreased food intake and increased ambulatory movement, without causing any change in total activity or energy expenditure when compared to saline-treated rats...
2017: PloS One
https://www.readbyqxmd.com/read/28533821/association-of-the-polymorphism-in-nucb2-gene-and-the-risk-of-type-2-diabetes
#19
Chunyu Wang, Yulun Wang, Wenchao Hu
BACKGROUND: Nesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>G (rs757081) polymorphism of NUCB2 gene with the presence of T2DM. METHODS: This study was performed in a population of 396 patients with T2DM and 196 healthy subjects. The c.1012C>G polymorphism of NUCB2 gene was determined using polymerase chain reaction and sequencing method...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28529367/serum-nucb2-nesfatin-1-levels-in-different-stages-of-alcohol-dependence-is-there-a-relationship-with-craving
#20
Gokhan Umut, Cuneyt Evren, Alparslan Cansiz, Mustafa Akkus, Nesrin Karamustafalioglu
INTRODUCTION: In the literature, the relationship between appetite regulating peptides and alcohol craving is on the debate. AIM: This study aims to investigate serum level of NUCB2/nesfatin-1, which is discovered as appetite-related neuropeptide, in patients with alcohol dependence who were in craving and abstaining phase and to compare with healthy controls. SETTINGS AND DESIGN: Research, Treatment, and Training Center for Alcohol and Substance Dependence, (AMATEM) Bakirkoy Training and Research Hospital for Psychiatry Neurology and Neurosurgery, Istanbul, case-control and prospective study design were used...
January 2017: Indian Journal of Psychiatry
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