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https://www.readbyqxmd.com/read/29151067/the-x-a-like-cell-revisited-spotlight-on-the-peripheral-effects-of-nucb2-nesfatin-1-and-ghrelin
#1
E Weibert, A Stengel
The gastric X/A-like cell was long thought to be restricted to the production of acyl ghrelin. However, the subsequent years witnessed the discovery of other peptide products derived from this cell, namely desacyl ghrelin, obestatin and nesfatin-1. While the role of obestatin remains highly questionable and is very critically discussed in the literature, besides acyl ghrelin also desacyl ghrelin and nesfatin-1 have been implicated in the regulation of food intake. As observed for several other peptide hormones before, ghrelin and nesfatin-1 are not restricted to one function but rather exert pleiotropic actions including effects on gastrointestinal motility, thermogenesis, lipid and glucose homeostasis, stress mediation, cardiovascular as well as reproductive functions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29131290/nesfatin-1-levels-in-patients-with-slow-coronary-flow
#2
Mevlüt Serdar Kuyumcu, Aliye Kuyumcu, Çağrı Yayla, Mustafa Bilal Özbay, Mehmet Alagöz, Sefa Ünal, Burak Açar, Özcan Özeke, Gülhan Samur
BACKGROUND: Nesfatin-1 is a novel found anorectic neuropeptide with potent metabolic regulatory effects. AIM: We aimed to evaluate the relationship between Nesfatin-1 levels and slow coronary flow (SCF). METHODS: A total of 60 consecutive patients with SCF and 60 consecutive patients with the normal coronary flow (NCF) were enrolled into the study. Nesfatin-1 level was measured from blood serum samples using enzyme-linked immunosorbent assay test...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29122953/dietary-weight-loss-induced-changes-in-rbp4-ffa-and-ace-predict-weight-regain-in-people-with-overweight-and-obesity
#3
Roel G Vink, Nadia J Roumans, Edwin C Mariman, Marleen A van Baak
Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled trial 26 males and 30 females (BMI: 28-35 kg/m(2)) followed either a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks followed by a weight stable period of 4 weeks (dietary intervention (DI) period) and a 9-month follow-up period...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29027818/effects-of-nesfatin-1-on-atrial-contractility-and-thoracic-aorta-reactivity-in-male-rats
#4
Ayşe Barutcigil, Arda Tasatargil
BACKGROUND: This study aimed to examine the effects of nesfatin-1 on thoracic aorta vasoreactivity and to investigate the inotropic and chronotropic effects of nesfatin-1 on the spontaneous contractions of the isolated rat atria. METHODS: Isolated right atria and thoracic aorta were used in organ baths. The reactivity of the thoracic aorta was evaluated by potassium chloride (KCl), phenylephrine (Phe), acetylcholine (ACh), and sodium nitroprusside (SNP). The effects of nesfatin-1 on the spontaneous contractions of the rat atria were also examined...
October 13, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28977160/serum-nesfatin-1-levels-are-decreased-in-pregnant-women-newly-diagnosed-with-gestational-diabetes
#5
Esra Nur Ademoglu, Suheyla Gorar, Muge Keskin, Ayse Carlioglu, Rifki Ucler, Husamettin Erdamar, Cavit Culha, Yalcin Aral
OBJECTIVE: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. SUBJECTS AND METHODS: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28965207/phoenixin-14-detection-and-novel-physiological-implications-in-cardiac-modulation-and-cardioprotection
#6
C Rocca, F Scavello, M C Granieri, T Pasqua, N Amodio, S Imbrogno, A Gattuso, R Mazza, Maria Carmela Cerra, Tommaso Angelone
Phoenixin-14 (PNX) is a newly identified peptide co-expressed in the hypothalamus with the anorexic and cardioactive Nesfatin-1. Like Nesfatin-1, PNX is able to cross the blood-brain barrier and this suggests a role in peripheral modulation. Preliminary mass spectrography data indicate that, in addition to the hypothalamus, PNX is present in the mammalian heart. This study aimed to quantify PNX expression in the rat heart, and to evaluate whether the peptide influences the myocardial function under basal condition and in the presence of ischemia/reperfusion (I/R)...
September 30, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28963067/nucb2-nesfatin-1-expression-and-functions-in-the-regulation-of-emotion-and-stress
#7
REVIEW
Yanyan Wei, Jiangbo Li, Huiling Wang, Gaohua Wang
Nesfatin-1, a food-intake inhibiting factor processed from nucleobindin 2 (NUCB2), was originally identified by the Oh-I research group. The initial functional studies on NUCB2/nesfatin-1 were mainly focused on its properties of appetite regulation. As is well known, emotional state has an interactional relationship with food intake, and difficulties in regulating emotion and stress have a great influence on appetite and body weight. Some anorexigenic or orexigenic neurotransmitters also play a role in the adjustment of emotion and stress responses in addition to their actions on the homeostatic regulation of food intake, including neuropeptide Y (NPY), melanocyte stimulating hormone (MSH), corticotropin-releasing factor (CRF), and ghrelin...
September 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28951234/activity-based-anorexia-activates-nesfatin-1-immunoreactive-neurons-in-distinct-brain-nuclei-of-female-rats
#8
Sophie Scharner, Philip Prinz, Miriam Goebel-Stengel, Reinhard Lommel, Peter Kobelt, Tobias Hofmann, Matthias Rose, Andreas Stengel
Activity-based anorexia (ABA) is an established animal model for the eating disorder anorexia nervosa (AN). The pathophysiology of AN and the involvement of food intake-regulatory peptides is still poorly understood. Nesfatin-1, an anorexigenic peptide also involved in the mediation of stress, anxiety and depression might be a likely candidate involved in the pathogenesis of AN. Therefore, activation of nesfatin-1 immunoreactive (ir) brain nuclei was investigated under conditions of ABA. Female Sprague-Dawley rats were used and divided into four groups (n=6/group): activity-based anorexia (ABA), restricted feeding (RF), activity (AC) and ad libitum fed (AL)...
December 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28878039/discovery-of-novel-representatives-of-bilaterian-neuropeptide-families-and-reconstruction-of-neuropeptide-precursor-evolution-in-ophiuroid-echinoderms
#9
Meet Zandawala, Ismail Moghul, Luis Alfonso Yañez Guerra, Jérôme Delroisse, Nikara Abylkassimova, Andrew F Hugall, Timothy D O'Hara, Maurice R Elphick
Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae, Amphiura filiformis and Ophiopsila aranea, has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28863435/erratum-to-gonadotropin-releasing-hormone-kisspeptin-and-gonadal-steroids-directly-modulate-nucleobindin-2-nesfatin-1-in-murine-hypothalamic-gonadotropin-releasing-hormone-neurons-and-gonadotropes
#10
https://www.readbyqxmd.com/read/28855042/insulinotropic-nucleobindin-2-nesfatin-1-is-dynamically-expressed-in-the-haemochorial-mouse-and-human-placenta
#11
Crystalyn B Legg-St Pierre, Martina Mackova, Ewa I Miskiewicz, Denise G Hemmings, Suraj Unniappan, Daniel J MacPhee
The placenta is the physiological bridge between mother and fetus and has life-sustaining functions during pregnancy, including metabolic regulation, fetal protection and hormone secretion. Nucleobindin-2 (NUCB2) is a calcium- and DNA-binding protein and precursor of nesfatin-1, a signalling peptide with multiple functions, including regulation of energy homeostasis and glucose transport. These are also key functions of the placenta, yet NUCB2/nesfatin-1 expression has never been comprehensively studied in this organ...
August 31, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28851749/the-thermogenic-effect-of-nesfatin-1-requires-recruitment-of-the-melanocortin-system
#12
Riccardo Dore, Luka Levata, Sogol Gachkar, Olaf Jöhren, Jens Mittag, Hendrik Lehnert, Carla Schulz
Nesfatin-1 is a bioactive polypeptide expressed both in the brain and peripheral tissues and involved in the control of energy balance by reducing food intake. Central administration of nesfatin-1 significantly increases energy expenditure, as demonstrated by a higher dry heat loss; yet, the mechanisms underlying the thermogenic effect of central nesfatin-1 remain unknown. Therefore, in this study, we sought to investigate whether the increase in energy expenditure induced by nesfatin-1 is mediated by the central melanocortin pathway, which was previously reported to mediate central nesfatin-1´s effects on feeding and numerous other physiological functions...
November 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28846666/interleukin-6-il-6-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-single-nucleotide-polymorphisms-snps-inflammation-and-metabolism-in-gestational-diabetes-mellitus-in-inner-mongolia
#13
Jie Zhang, Haiyi Chi, Huiying Xiao, Xiaoyan Tian, Yilin Wang, Xia Yun, Yancheng Xu
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on the association of IL-65-72C/G and TNF-α -857C/T single nucleotide polymorphisms (SNPs), inflammatory biomarkers, and metabolic indexes in women with GDM, especially in the Inner Mongolia population. The aim of this study was to investigate the associations of IL-65-72C/G and TNF-α -857C/T SNPs, and inflammation and metabolic biomarkers in women with GDM pregnancies...
August 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28838338/ghrelin-and-nucb2-nesfatin-1-expression-in-unilateral-testicular-torsion-induced-rats-with-and-without-n-acetylcysteine
#14
M Sarac, U Bakal, T Tartar, T Kuloglu, M Yardim, G Artas, S Aydin, A Kazez
Testicular torsion (TT) is a common urological problem in the field of pediatric surgery. The degree and duration of torsion determines the degree of testicular damage; however, its effects on the expression of octanoylated ghrelin and nucleobindin 2 (NUCB2) /nesfatin-1 synthetized from testicular tissue remain unclear. We explored the effects of experimentally induced unilateral TT on serum and contralateral testicular tissue ghrelin and NUCB2/nesfatin-1 levels, and determined whether N-acetyl cysteine (NAS) treatment had any effects on their expression...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28814086/plasma-nesfatin-1-level-in-patients-with-first-attack-psychosis
#15
M Sahpolat, M Ari
OBJECTIVES: This study aimed to investigate the possible relationship between plasma concentrations of nesfatin 1 and first attack psychosis. METHODS: Totally, 32 patients with the first episode psychosis and 33 randomly selected weight- and body mass index-matched healthy volunteers admitted to Mustafa Kemal University, Faculty of Medicine, Training and Research Hospital, Psychiatry outpatient clinic were included. Healthy control subjects were matched in terms of weight and body mass index (BMI)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28807720/comparison-of-the-therapeutic-effects-of-sildenafil-citrate-heparin-and-neuropeptides-in-a-rat-model-of-acetic-acid-induced-gastric-ulcer
#16
COMPARATIVE STUDY
Mehmet Kalayci, Mehmet Ali Kocdor, Tuncay Kuloglu, İbrahim Sahin, Mehmet Sarac, Aziz Aksoy, Meltem Yardim, Semih Dalkilic, Onur Gursu, Suna Aydin, Ramazan Fazil Akkoc, Meltem Ugras, Gokhan Artas, İbrahim Hanifi Ozercan, Kader Ugur, Suleyman Aydin
AIMS: The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS: The animals were divided into 13 groups, with 4 animals in each. Gastric ulcers was induced in the animals of 12 groups with one untreated group being left as the control (Group I - control; given normal saline (NS))...
October 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28796641/the-effect-of-thyroid-dysfunction-on-nesfatin-1-and-adiponectin-levels-in-rats
#17
Emine Atıci, Rasim Mogulkoc, Abdulkerim Kasım Baltaci, Esma Menevse
Background Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1...
August 10, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28795473/gastrointestinal-peptides-during-chronic-gastric-electrical-stimulation-in-patients-with-intractable-vomiting
#18
Mathieu Meleine, Chloé Melchior, Philip Prinz, Alfred Penfornis, Benoît Coffin, Andreas Stengel, Philippe Ducrotté, Guillaume Gourcerol
OBJECTIVES: Gastric electrical stimulation (GES) is an alternative therapy to treat patients with intractable vomiting. A preclinical study has demonstrated the modulation of the gastrointestinal (GI) peptide ghrelin by GES but such mechanism has never been investigated in patients. The aim of this work was to assess the effect of GES on GI peptide levels in patients with intractable vomiting. MATERIALS AND METHODS: Twenty-one patients were randomized to receive either ON or OFF GES, 14 completed the study (10 ON, 4 OFF stimulation)...
August 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28762571/sex-specific-differences-in-cardiovascular-and-metabolic-hormones-with-integrated-signalling-in-the-paraventricular-nucleus-of-the-hypothalamus
#19
Spencer P Loewen, Alex R Paterson, Su Yi Loh, Mark F Rogers, Charles C T Hindmarch, David Murphy, Alastair V Ferguson
What is the topic of this review? We describe roles of crucial signalling molecules in the paraventricular nucleus of the hypothalamus and highlight recent data suggesting sex-specific changes in the expression of crucial signalling molecules and their receptors, which may underlie sex differences in both cardiovascular and metabolic function. What advances does it highlight? This review highlights the integrative capacity of the paraventricular nucleus in mediating cardiovascular and metabolic effects by integrating information from multiple signalling molecules...
August 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28739555/serum-nesfatin-1-levels-in-girls-with-idiopathic-central-precocious-puberty
#20
Ayça Altıncık, Oya Sayın
OBJECTIVE: Nesfatin-1, which is defined as an anorexigenic neuropeptide, is expressed mainly in central nervous system and in some periferic tissues. The role of nesfatin-1 in energy balance has been investigated; however, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty; and ii) relationship between nesfatin-1 and anthropometric measures, gonadotropin levels in girls with idiopathic central precocious puberty (CPP)...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
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