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https://www.readbyqxmd.com/read/27852303/the-effects-of-nigella-sativa-on-thyroid-function-serum-vascular-endothelial-growth-factor-vegf-1-nesfatin-1-and-anthropometric-features-in-patients-with-hashimoto-s-thyroiditis-a-randomized-controlled-trial
#1
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri, Mehran Mesgari Abbasi
BACKGROUND: Hashimoto's thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment of several chronic diseases including hyperlipidemia, hypertension and type 2 diabetes mellitus (T2DM). The aim of the current study was to evaluate the effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis...
November 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27824141/nesfatin-1-promotes-brown-adipocyte-phenotype
#2
Yuexin Wang, Ziru Li, Xinyu Zhang, Xinxin Xiang, Yin Li, Michael W Mulholland, Weizhen Zhang
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the differentiation and lipid metabolism of brown adipocytes remains unknown. In the present study, we found that nesfatin-1 mRNA and protein were detectable in isolated brown adipocytes and gradually decreased during differentiation (95% CI 0.6057 to 1.034, p = 0.0001). The decrease in nesfatin-1 was associated with a significant reduction in p-S6. Exposure to nesfatin-1 promoted differentiation of brown adipocytes as revealed by a significant increase in UCP1 mRNA (p = 0...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754932/nesfatin-1-functions-and-physiology-of-a-novel-regulatory-peptide
#3
Riccardo Dore, Luka Levata, Hendrik Lehnert, Carla Schulz
Nesfatin-1 was identified in 2006 as a potent anorexigenic peptide involved in the regulation of homeostatic feeding. It is processed from the precursor-peptide NEFA/nucleobindin 2 (NUCB2) which is expressed both in the central nervous system as well as in the periphery, from where it can access the brain via non-saturable transmembrane diffusion. In hypothalamus and brainstem, nesfatin-1 recruits the oxytocin-, the melancortin- and other systems to relay its anorexigenic properties. NUCB2/nesfatin-1 peptide expression in reward-related areas suggests that nesfatin-1 might also be involved in hedonic feeding...
October 17, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27752839/levels-of-metabolic-markers-in-drug-naive-prediabetic-and-type-2-diabetic-patients
#4
Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani
AIMS: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. METHODS: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected...
October 18, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27681383/association-between-nesfatin-1-levels-and-metabolic-improvements-in-severely-obese-patients-who-underwent-biliopancreatic-derivation-with-duodenal-switch
#5
REVIEW
David H St-Pierre, Julie Martin, Hiroyuki Shimizu, Yuko Tagaya, Takahumi Tsuchiya, Simon Marceau, Laurent Biertho, Marjorie Bastien, Sarah-Maude Caron-Cantin, Serge Simard, Denis Richard, Katherine Cianflone, Paul Poirier
CONTEXT: Nesfatin-1 is a neuroendocrine peptide with potent anorexigenic activity in rodents. The potential role of nesfatin-1 on the regulation of energy balance, metabolic functions and inflammation is currently debated in obese humans. In the present study, nesfatin-1 fluctuations and their associations with metabolic factors were investigated in severely obese patients who underwent biliopancreatic diversion with duodenal switch (BPD/DS) and severely obese controls (SOC). BASIC PROCEDURES: Sixty severely obese patients who underwent BPD/DS and 15 SOC (matched for BMI and age) were included in the study...
December 2016: Peptides
https://www.readbyqxmd.com/read/27599613/role-of-nesfatin-1-in-the-reproductive-axis-of-male-rat
#6
Xiaoxiao Gao, Kaifa Zhang, Min Song, Xiumei Li, Lei Luo, Yuan Tian, Yunhai Zhang, Yunsheng Li, Xiaorong Zhang, Yinghui Ling, Fugui Fang, Ya Liu
Nesfatin-1 is an important molecule in the regulation of reproduction. However, its role in the reproductive axis in male animals remains to be understood. Here, we found that nesfatin-1 was mainly distributed in the arcuate nucleus (ARC), paraventricular nucleus (PVN), periventricular nucleus (PeN), and lateral hypothalamic area (LHA) of the hypothalamus; adenohypophysis and Leydig cells in male rats. Moreover, the concentrations of serum nesfatin-1 and its mRNA in hypothalamo-pituitary-gonadal axis (HPGA) vary with the age of the male rat...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27589697/expression-and-regulation-of-peripheral-nucb2-nesfatin-1
#7
Philip Prinz, Andreas Stengel
Nesfatin-1, an 82 amino acid peptide was discovered in 2006 in the rat hypothalamus and described as a centrally acting anorexigenic peptide. Besides its central expression and actions, NUCB2/nesfatin-1 has been subsequently described to be predominantly expressed in the periphery and to exert several peripheral effects. The current review focuses on the expression sites of NUCB2/nesfatin-1 in peripheral tissues of different species and its regulation by nutrition, body weight and various other parameters such as fetal development and sex...
August 30, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27589696/nesfatin-1-current-status-as-a-peripheral-hormone-and-future-prospects
#8
Philip Prinz, Andreas Stengel
This review summarizes current data focusing on the peripheral effects of NUCB2/nesfatin-1 including the regulation of food intake, glucose homeostasis, lipid metabolism, cardiovascular effects and reproductive functions as well as its possible involvement in psychological disorders. Additionally, we will highlight gaps in knowledge in order to stimulate further research. Lastly, we will give an outlook on potential therapeutic implications of this pleiotropic peptide.
August 30, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27539099/serum-nesfatin-1-levels-in-patients-with-different-glucose-tolerance-levels
#9
S Algul, Y Ozkan, O Ozcelik
The aim of this study was to compare the levels of nesfatin-1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C), impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), metabolic syndrome (MS) and type 2 diabetes mellitus, (Type 2 DM). Glycated hemoglobin (HbA1c) assessed the glycemic control. Homeostasis model assessment of insulin resistance (HOMA-IR) was determined using computer analyses...
August 19, 2016: Physiological Research
https://www.readbyqxmd.com/read/27525002/comparison-of-the-effects-of-glutamine-curcumin-and-nesfatin-1-on-the-gastric-serosal-surface-neomucosa-formation-an-experimental-rodent-model
#10
Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yiğitbaş, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Sinan Arici, Asli Kahraman Akkalp, Tulin Sarac, Fatih Çelebi, Atilla Celik
Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27524109/nesfatin-1-alleviates-extrahepatic-cholestatic-damage-of-liver-in-rats
#11
Ali Solmaz, Osman Bilgin Gülçiçek, Candaş Erçetin, Hakan Yiğitbaş, Erkan Yavuz, Sinan Arıcı, Can Erzik, Oğuzhan Zengi, Pelin Demirtürk, Atilla Çelik, Fatih Çelebi
Obstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic effects of nesfatin-1 on OJ in rats. Twenty-four adult male Wistar-Hannover rats were randomly assigned to three groups: sham (n = 8), control (n = 8), and nesfatin (n = 8)...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27508828/-op-7b-09-chemerin-and-blood-pressure-and-metabolic-syndrome-in-postmenopausal-women
#12
A Olszanecka, K Kawecka-Jaszcz, D Czarnecka
OBJECTIVE: Chemerin is recently identified adipose hormone, which plays a role in adipogenesis, energy metabolism and inflammation. Increased levels of chemerin have been linked to obesity and development of diabetes mellitus. During the transition from premenopause to postmenopause, many women experience weight gain and central fat deposition, hence we hypothesized that circulating level of chemerin can play a role in the pathogenesis of hypertension and cardiometabolic risk in postmenopausal females...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27459811/-change-in-plasma-nesfatin-1-concentration-within-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-rat-models
#13
Rui Wu, Zheng Chen, Yayun Xu, Jinfang Ge, Xiongwen Lü
OBJECTIVE: To investigate the change of plasma nesfatin-1 concentration in a nonalcoholic fatty liver disease rat model induced by high-fat diet, and explore its effect on the dysfunction of glucose and lipid metabolism. METHODS: The nonalcoholic fatty liver disease rat model was established through introduction of a high-fat diet, and four weeks later, the intraperitoneal glucose tolerance test was conducted. Serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected using chemiluminescence technique...
May 2016: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/27396908/peripheral-injection-of-bombesin-induces-c-fos-in-nucb2-nesfatin-1-neurons
#14
Kim-Marie Engster, Arthur L Kroczek, Matthias Rose, Andreas Stengel, Peter Kobelt
As anorexigenic hormones bombesin and nucleobindin2 (NUCB2)/nesfatin-1 decrease food intake in rodents. Both hormones have been described in brain nuclei that play a role in the modulation of hunger and satiety, like the paraventricular nucleus of the hypothalamus (PVN) and the nucleus of the solitary tract (NTS). However, the direct interaction of the two hormones is unknown so far. The aim of study was to elucidate whether bombesin directly interacts with NUCB2/nesfatin-1 neurons in the PVN and NTS. Therefore, we injected bombesin intraperitoneally (ip) at two doses (26 and 32nmol/kg body weight) and assessed c-Fos activation in the PVN, arcuate nucleus (ARC) and NTS compared to vehicle treated rats (0...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27380730/nesfatin-1-nucb2-in-the-amygdala-influences-visceral-sensitivity-via-glucocorticoid-and-mineralocorticoid-receptors-in-male-maternal-separation-rats
#15
X-P Zhou, J Sha, L Huang, T-N Li, R-R Zhang, M-D Tang, L Lin, X-L Li
BACKGROUND: Nesfatin-1, a recently identified satiety molecule derived from nucleobindin 2 (NUCB2), is associated with visceral hypersensitivity in rats and is expressed in the amygdala. We tested the hypothesis that nesfatin-1 expression in the amygdala is involved in the pathogenesis of irritable bowel syndrome (IBS) visceral hypersensitivity. METHODS: An animal model of IBS-like visceral hypersensitivity was established using maternal separation (MS) during postnatal days 2-16...
October 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27329836/nesfatin-1-like-peptide-encoded-in-nucleobindin-1-in-goldfish-is-a-novel-anorexigen-modulated-by-sex-steroids-macronutrients-and-daily-rhythm
#16
Lakshminarasimhan Sundarrajan, Ayelén Melisa Blanco, Juan Ignacio Bertucci, Naresh Ramesh, Luis Fabián Canosa, Suraj Unniappan
Nesfatin-1 is an 82 amino acid anorexigen encoded in a secreted precursor nucleobindin-2 (NUCB2). NUCB2 was named so due to its high sequence similarity with nucleobindin-1 (NUCB1). It was recently reported that NUCB1 encodes an insulinotropic nesfatin-1-like peptide (NLP) in mice. Here, we aimed to characterize NLP in fish. RT- qPCR showed NUCB1 expression in both central and peripheral tissues. Western blot analysis and/or fluorescence immunohistochemistry determined NUCB1/NLP in the brain, pituitary, testis, ovary and gut of goldfish...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27281021/role-of-brain-nucb2-nesfatin-1-in-the-stress-induced-modulation-of-gastrointestinal-functions
#17
Miriam Goebel-Stengel, Andreas Stengel
Nucleobindin2 (NUCB2)/nesfatin-1 plays a well-established role in homeostatic functions associated with food intake and stress integration. This review focuses on NUCB2/nesfatin-1's central effects on gastrointestinal functions and will summarize the effects on food intake, motility and secretion with focus on the upper gastrointestinal tract. We will highlight the stressors that influence brain NUCB2/nesfatin-1 expression and discuss functional implications. In addition to traditional acute psychological and physical stressors such as restraint stress and abdominal surgery we will look at immunological, visceral and metabolic stressors as well as a chronic combination stress model that have been shown to affect NUCB2/nesfatin-1 signalling and describe associated functional consequences...
June 1, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27235705/annals-express-concentrations-of-prealbumin-and-some-appetite-controlling-hormones-in-women-with-hyperemesis-gravidarium
#18
Gulfer Ozturk, A Seval Ozgu-Erdinc, Fatma Ucar, Zeynep Ginis, Gonul Erden, Nuri Danisman
BACKGROUND: Hyperemesis gravidarum (HG), which affects 0.3-2.3% of pregnancies, is defined as excessive vomiting during pregnancy and usually starts in week 4 or 5 of gestation. Symptoms include weight loss, dehydration, ketonaemia, ketonuria, fasting acidosis, alkalosis due to hydrochloric acid loss and hypokalaemia and its exact cause is unknown. The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with HG METHODS: : A total of 40 pregnant women with HG and 38 pregnant women without HG as controls, were included in this study...
May 27, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27209204/molecular-and-behavioral-profiling-of-dbx1-derived-neurons-in-the-arcuate-lateral-and-ventromedial-hypothalamic-nuclei
#19
Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa, Joshua G Corbin
BACKGROUND: Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as anxiety, depression or obesity. Despite many studies of hypothalamic development and function, the link between embryonic development and innate behaviors remains unexplored. Here, focusing on the embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored the relationship between embryonic lineage, post-natal neuronal identity and lineage-specific responses to innate cues...
2016: Neural Development
https://www.readbyqxmd.com/read/27203571/activation-of-nesfatin-1-containing-neurones-in-the-hypothalamus-and-brainstem-by-peripheral-administration-of-anorectic-hormones-and-suppression-of-feeding-via-central-nesfatin-1-in-rats
#20
R Saito, M So, Y Motojima, T Matsuura, M Yoshimura, H Hashimoto, Y Yamamoto, K Kusuhara, Y Ueta
Peripheral anorectic hormones, such as glucagon-like peptide (GLP)-1, cholecystokinin (CCK)-8 and leptin, suppress food intake. The newly-identified anorectic neuropeptide, nesfatin-1, is synthesised in both peripheral tissues and the central nervous system, particularly by various nuclei in the hypothalamus and brainstem. In the present study, we examined the effects of i.p. administration of GLP-1 and CCK-8 and co-administrations of GLP-1 and leptin at subthreshold doses as confirmed by measurement of food intake, on nesfatin-1-immunoreactive (-IR) neurones in the hypothalamus and brainstem of rats by Fos immunohistochemistry...
September 2016: Journal of Neuroendocrinology
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