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https://www.readbyqxmd.com/read/28522911/study-of-the-effects-of-nesfatin-1-on-gastric-function-in-obese-rats
#1
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong
AIM: To investigate the effects of nesfatin-1 on gastric function in obese rats. METHODS: The obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of H+/K+-ATPase was measured using RT-PCR and western blot to preliminarily explore the mechanism of gastric acid secretion changes...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28484746/testosterone-regulates-nucb2-mrna-expression-in-male-mouse-hypothalamus-and-pituitary-gland
#2
Sojeong Seon, Daun Jeon, Heejeong Kim, Yiwa Chung, Narae Choi, Hyunwon Yang
Nesfatin-1/NUCB2 is known to take part in the control of the appetite and energy metabolism. Recently, many reports have shown nesfatin-1/NUCB2 expression and function in various organs. We previously demonstrated that nesfatin-1/NUCB2 expression level is higher in the pituitary gland compared to other organs and its expression is regulated by 17β-estradiol and progesterone secreted from the ovary. However, currently no data exist on the expression of nesfatin-1/NUCB2 and its regulation mechanism in the pituitary of male mouse...
March 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28484742/serum-cytokine-levels-are-related-to-nesfatin-1-nucb2-expression-in-the-implantation-sites-of-spontaneous-abortion-model-of-cba-j-%C3%A3-dba-2-mice
#3
Yiwa Chung, Heejeong Kim, Sojeong Seon, Hyunwon Yang
The process of spontaneous abortion involves a complex mechanism with various cytokines, growth factors, and hormones during the pregnancy. However, the mechanism underlying spontaneous abortion by pro- and anti-inflammatory cytokines in the serum during the pregnancy is not fully understood. Therefore, the purpose of this study was to examine the relationship between the serum levels of pro- and anti-inflammatory cytokines and spontaneous abortion using the CBA/j × DBA/2 mouse model. Serum levels of pro-inflammatory cytokines, such as IFN-γ, IL-1α and TNF-α were not increased in abortion model mice, but anti-inflammatory cytokines, such as IL-4, IL-13 and IL-1ra were decreased compared to normal pregnant mice...
March 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28484396/nesfatin-1-in-the-lateral-parabrachial-nucleus-inhibits-food-intake-modulates-excitability-of-glucosensing-neurons-and-enhances-ucp1-expression-in-brown-adipose-tissue
#4
Jun-Hua Yuan, Xi Chen, Jing Dong, Di Zhang, Kun Song, Yue Zhang, Guang-Bo Wu, Xi-Hao Hu, Zheng-Yao Jiang, Peng Chen
Nesfatin-1, an 82-amino acid neuropeptide, has been shown to induce anorexia and energy expenditure. Food intake is decreased in ad libitum-fed rats following injections of nesfatin-1 into the lateral, third, or fourth ventricles of the brain. Although the lateral parabrachial nucleus (LPBN) is a key regulator of feeding behavior and thermogenesis, the role of nesfatin-1 in this structure has not yet been delineated. We found that intra-LPBN microinjections of nesfatin-1 significantly reduced nocturnal cumulative food intake and average meal sizes without affecting meal numbers in rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28452726/-nesfatin-1-activity-in-patients-with-essential-hypertension-and-prediabetes-type-2-diabetes
#5
O Kovalyova, T Ashcheulova, A Demydenko, M Vizir, O Kochubiei
Essential hypertension (EH) is one of the important problems and comorbidity negatively affects the prognosis of the disease. Substantial thing is investigation of metabolic substances that influence the carbohydrate profile. Aim - investigation of the nesfatin-1 activity in patients with Essential hypertension and prediabetes/type2 diabetes. 83 patients with EH were examined and divided into groups according to dysglicemia and abdominal obesity. Significant increasing of nesfatin-1 in patients with EH 7,81±0,26 ng/ml was found comparing to controls 4,54±0,13 ng/ml, p<0,05...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28446807/increased-blood-pressure-in-nesfatin-nuclebindin-2-transgenic-mice
#6
Yusaku Mori, Hiroyuki Shimizu, Hideki Kushima, Munenori Hiromura, Michishige Terasaki, Michitaka Tanaka, Aya Osaki, Tsutomu Hirano
Nesfatin/nucleobindin-2 (nesf/NUCB2), a precursor of the anorexigenic protein nesfatin-1, is selectively expressed in the hypothalamic nuclei, which are central to the regulation of the autonomic nervous system. The present study sought to investigate the involvement of nesf/NUCB2 in the regulation of blood pressure and ingestive behavior, by using nesf/NUCB2-transgenic (Tg) mice. Blood pressure and heart rates were measured under conscious and unconscious conditions. Twenty-four-hour water intake and urine volume of male nesf/NUCB2-Tg mice and their littermates in metabolic cages were measured...
April 27, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28374855/fibroblast-growth-factor-21-assisted-by-elevated-glucose-activates-paraventricular-nucleus-nucb2-nesfatin-1-neurons-to-produce-satiety-under-fed-states
#7
Putra Santoso, Masanori Nakata, Kazuhiro Shiizaki, Zhang Boyang, Kumari Parmila, Zesemdorj Otgon-Uul, Koshi Hashimoto, Tetsurou Satoh, Masatomo Mori, Makoto Kuro-O, Toshihiko Yada
Fibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and diabetes. However, its anorexigenic effect is debatable and whether it involves the central mechanism remains unclarified. Moreover, the neuron mediating FGF21's anorexigenic effect and the systemic energy state supporting it are unclear. We explored the target neuron and fed/fasted state dependence of FGF21's anorexigenic action. Intracerebroventricular (ICV) injection of FGF21 markedly suppressed food intake in fed mice with elevated blood glucose...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28361552/serum-levels-of-nesfatin-1-are-increased-in-gestational-diabetes-mellitus
#8
Ying Zhang, Jia-Hui Lu, Si-Yuan Zheng, Jia-He Yan, Lin Chen, Xin Liu, Wei-Zhen Wu, Fang Wang
OBJECTIVE: To analyze the concentrations of nesfatin-1 in maternal and cord serum, to evaluate the expression of nesfatin-1 in subcutaneous adipose tissue (SAT) from pregnant women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT). METHODS: We studied a total of 50 GDM and 50 NGT subjects. The clinical features, serum nesfatin-1, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profiles were measured at the third trimester of pregnancy...
March 31, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28339602/gonadotropin-releasing-hormone-kisspeptin-and-gonadal-steroids-directly-modulate-nucleobindin-2-nesfatin-1-in-murine-hypothalamic-gonadotropin-releasing-hormone-neurons-and-gonadotropes%C3%A2
#9
A Hatef, S Unniappan
Neuroendocrine regulation of metabolism and reproduction are tightly interlinked. Nesfatin-1 is an 82 amino acid metabolic peptide derived from nucleobindin-2 (NUCB2). NUCB2 mRNA and protein significantly increase in the hypothalamus of rats during puberty-to-adult transition. Administration of nesfatin-1 modulates circulating LH and testosterone in male rats. However, whether nesfatin-1 acts directly on neurons and gonadotropes remain unknown. In addition, whether reproductive hormones of the hypothalamo-pituitary gonadal axis modulate NUCB2/nesfatin-1 is unclear...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28277136/the-role-of-nesfatin-1-expression-in-letrozole-induced-polycystic-ovaries-in-the-rat
#10
Yingqiao Xu, Hua Zhang, Qingchun Li, Kaixue Lao, Yanlin Wang
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder, generally exhibiting the characteristic features of hyperandrogenemia, insulin resistance (IR) and obesity. Nesfatin-1 is derived from the precursor nucleobindin2 (NUCB2), and plays an active role in energy balance, glucose metabolism and most likely gonadal function. In order to explore the role of nesfatin-1, we employed a rat model that uses letrozole to induce PCOS. The PCOS rats exhibited increased body weight, irregular cycles, polycystic ovaries characterized by cysts formed from atretic follicles, and a diminished granulosa layer...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28273586/alterations-of-circulating-nucb2-nesfatin-1-during-short-term-therapeutic-improvement-of-anxiety-in-obese-inpatients
#11
Tobias Hofmann, Elena Weibert, Anne Ahnis, Alexander Obbarius, Ulf Elbelt, Matthias Rose, Burghard F Klapp, Andreas Stengel
In addition to its anorexigenic properties in the neuroendocrine regulation of hunger and satiety, mounting evidence indicates a role for NUCB2/nesfatin-1 in the regulation of emotional stress responses which seems to occur in a sex-specific way. In the present study, we investigated the association of NUCB2/nesfatin-1 plasma levels with anxiety, depressiveness and perceived stress in obese men and women and their alterations during inpatient treatment. We expected a decrease of NUCB2/nesfatin-1 levels in female and an increase in male patients reporting a relevant alleviation of anxiety...
February 21, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28228069/recent-advances-in-the-gastric-mucosal-protection-against-stress-induced-gastric-lesions-importance-of-renin-angiotensin-vasoactive-metabolites-gaseous-mediators-and-appetite-peptides
#12
Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki, Ryszard Korbut
Stress is known to cause severe adverse effects in the human gastrointestinal tract including mucosal microbleedings and erosions or even gastric ulceration but the mechanism of these complications has not been fully elucidated. The pathogenesis of stress-induced gastric damage involves the fall in gastric blood flow (GBF), an increase in gastric acid secretion and gastric motility, enhanced adrenergic and cholinergic nerve activity and the rise in gastric mucosal generation of reactive oxygen species. The gastric mucosal defense mechanisms against the deleterious effect of stress include the activation of the hypothalamic-pituitary-adrenal axis which has been linked with glucocorticoids release capable of counteracting of stress-induced gastric lesions...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28211103/impaired-learning-and-memory-in-rats-induced-by-a-high-fat-diet-involvement-with-the-imbalance-of-nesfatin-1-abundance-and-copine-6-expression
#13
Zheng Chen, Ya-Yun Xu, Rui Wu, Yin-Xiu Han, Yue Yu, Jin-Fang Ge, Fei-Hu Chen
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, resulting not only in liver dysfunction, glucose and lipid metabolism disorder, but also in neuropsychiatric damage. In the present study, a NAFLD rat model was established via feeding of a high-fat diet, and the behavior was observed via the open field test (OFT), the sucrose preference test (SPT), the elevated plus maze (EPM), the forced swimming test (FST), and the Morris water maze (MWM). The plasma concentrations of alanine aminotransferase (ALT), glucose, free fatty acid (FFA), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were detected using chemiluminescence technique...
February 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28138998/current-and-prospective-sights-in-mechanism-of-deoxynivalenol-induced-emesis-for-future-scientific-study-and-clinical-treatment
#14
REVIEW
Liangkai Chen, Zhao Peng, Andreas K Nüssler, Liegang Liu, Wei Yang
Deoxynivalenol (DON), one of trichothecene mycotoxins produced by the fungus Fusarium, is commonly detected in cereal foods and in secondary food production across the world. Lower concentrations of DON induce a dose-related feed refusal (anorexia), whereas it acts as a potent emetic agent at higher levels. DON-induced emesis in humans and livestock can be observed and recorded in both undeveloped and developed regions such as Lixian, Guide and Huangzhong in China and Illinois in the USA. Some studies with different animal models (pigs and minks) suggested that DON could change expressions of 5-hydroxytryptamine, peptide YY, neuropeptide Y2 receptor and nucleobindin-2/nesfatin-1 in plasma and different areas of the brain...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28137218/metabolic-and-cardiovascular-actions-of-nesfatin-1-implications-in-health-and-disease
#15
Naresh Ramesh, Kavishankar Gawli, Venkatakiran Pasupulleti, Suraj Unniappan
BACKGROUND: Metabolic homeostasis is achieved by proper functioning of a complex endocrine milieu, comprising of signals arising from the brain and peripheral tissues. Our knowledge of the factors regulating such balance is rapidly evolving, as new signaling molecules are characterized. Of central interest is nesfatin-1, owing to its multifunctional tissue specific actions regulating food intake, body weight, blood glucose and cardiac functions. METHOD: This review discusses the tissue/system wide distribution and actions of nesfatin-1 in regulating metabolic and cardiovascular functions in healthy conditions and diseases...
January 30, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28106099/nesfatin-1-protects-dopaminergic-neurons-against-mpp-mptp-induced-neurotoxicity-through-the-c-raf-erk1-2-dependent-anti-apoptotic-pathway
#16
Xiao-Li Shen, Ning Song, Xi-Xun Du, Yong Li, Jun-Xia Xie, Hong Jiang
Several brain-gut peptides have been reported to have a close relationship with the central dopaminergic system; one such brain-gut peptide is nesfatin-1. Nesfatin-1 is a satiety peptide that is predominantly secreted by X/A-like endocrine cells in the gastric glands, where ghrelin is also secreted. We previously reported that ghrelin exerted neuroprotective effects on nigral dopaminergic neurons, which implied a role for ghrelin in Parkinson's disease (PD). In the present study, we aim to clarify whether nesfatin-1 has similar effects on dopaminergic neurons both in vivo and in vitro...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096522/control-of-food-intake-by-gastrointestinal-peptides-mechanisms-of-action-and-possible-modulation-in-the-treatment-of-obesity
#17
REVIEW
Philip Prinz, Andreas Stengel
This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative-physical activity and pharmacotherapy-treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways...
April 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28089858/glucose-amino-acids-and-fatty-acids-directly-regulate-ghrelin-and-nucb2-nesfatin-1-in-the-intestine-and-hepatopancreas-of-goldfish-carassius-auratus-in-vitro
#18
Juan Ignacio Bertucci, Ayelén Melisa Blanco, Luis Fabián Canosa, Suraj Unniappan
Ghrelin and nesfatin-1 are two peptidyl hormones primarily involved in food intake regulation. We previously reported that the amount of dietary carbohydrates, protein and lipids modulates the expression of these peptides in goldfish in vivo. In the present work, we aimed to characterize the effects of single nutrients on ghrelin and nesfatin-1 in the intestine and hepatopancreas. First, immunolocalization of ghrelin and NUCB2/nesfatin-1 in goldfish hepatopancreas cells was studied by immunohistochemistry. Second, the effects of 2 and 4hour-long exposures of cultured intestine and hepatopancreas sections to glucose, l-tryptophan, oleic acid, linolenic acid (LNA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on ghrelin and nesfatin-1 gene and protein expression were studied...
January 13, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28087413/nesfatin-1-modulates-murine-gastric-vagal-afferent-mechanosensitivity-in-a-nutritional-state-dependent-manner
#19
Stephen J Kentish, Hui Li, Claudine L Frisby, Amanda J Page
Food intake is regulated by vagal afferent signals from the stomach. Nesfatin-1 is an anorexigenic peptide produced within the gastrointestinal tract and has well defined central effects. We aimed to determine if nesfatin-1 can modulate gastric vagal afferent signals in the periphery and further whether this is altered in different nutritional states. Female C57BL/6J mice were fed either a standard laboratory diet (SLD) or a high fat diet (HFD) for 12 weeks or fasted overnight. Plasma nucleobindin-2 (NUCB2; nesfatin-1 precursor)/nesfatin-1 levels were assayed, the expression of NUCB2 in the gastric mucosa and adipose tissue was assessed using real-time quantitative reverse-transcription polymerase chain reaction...
March 2017: Peptides
https://www.readbyqxmd.com/read/28079928/relation-of-serum-and-vitreous-nesfatin-1-concentrations-with-diabetic-retinopathy
#20
Rongfeng Dai, Guohua Deng, Zhuo Sun, Zhinan Liu, Yu Qian, Yan Han
OBJECTIVE: Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR). METHODS: This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients...
January 12, 2017: Journal of Clinical Laboratory Analysis
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