Read by QxMD icon Read


Xinkuan Liu, Wenyi Shao, Mingyi Luo, Jiayin Bian, Deng-Guang Yu
Nanomaterials providing sustained release profiles are highly desired for efficacious drug delivery. Advanced nanotechnologies are useful tools for creating elaborate nanostructure-based nanomaterials to achieve the designed functional performances. In this research, a modified coaxial electrospinning was explored to fabricate a novel core-sheath nanostructure (nanofibers F2), in which a sheath drug-free gliadin layer was successfully coated on the core ketoprofen (KET)-gliadin nanocomposite. A monolithic nanocomposite (nanofibers F1) that was generated through traditional blending electrospinning of core fluid was utilized as a control...
March 22, 2018: Nanomaterials
Hui Wang, Tao Feng, Ning Hai Zhuang, Min Zhi Xu, Ran Ye, Min Sun
This review attempts to visualize the actual impact of starch nanoparticle-based materials in different areas. In recent patent databases, starch nanoparticles showed the importance of this material, as well as relevant topics concerning the applications of starch nanoparticles in different domains. Because starch is environmentally friendly, starch nanoparticles are suggested as one of the promising biomaterials for novel utilization in foods, papermaking, medicines as well as various composites. In this review, the most common techniques for starch nanoparticles preparation were found to be acid and enzymatic procedures, ultrasonic treatment, combination of hydrolysis and Ultrasonic treatment, high pressure homogenization, enzymatic hydrolysis and recrystallization and emulsion-crosslinking...
March 20, 2018: Recent Patents on Food, Nutrition & Agriculture
Xingmei Duan, Minjie Mu, Junfeng Yan, Lan Bai, Lei Zhong, Yuxuan Zhu, Haixia Pan, Mei Zhang, Jianyou Shi
Background: The newly synthesized Aurora-A kinase inhibitor XY-4 is a potential anti-cancer agent, but its hydrophobicity and limited efficiency restrict further application. Nanotechnology based combined therapy provides an optimized strategy for solving these issues. Methods: In this study, the newly synthesized Aurora-A kinase inhibitor XY-4 and Bcl-xl targeted siRNA were co-delivered by cationic liposomes, creating an injectable co-delivery formulation. The anti-cancer ability and mechanisms of XY-4/Bcl-xl siRNA co-loaded cationic liposomes were studied both in vitro and in vivo...
2018: International Journal of Nanomedicine
Lamia El Badawi
In a 2012 opinion, the common consultative committee of ethics of the INRA and the CIRAD commented on the known and potential applications of nanotechnologies in agriculture and food domains. He recommends the adoption of sufficient measures of evaluation and risk assessment and management for the time being still insufficient. He also recommends for the researchers to be the main interlocutor not only of the sanitary and environmental public authorities but also of the citizens who do not perceive the practical interest of these technologies...
October 13, 2017: Journal International de Bioéthique et D'éthique des Sciences
Morteza Mahmoudi
Despite considerable efforts in the field of nanomedicine that have been made by researchers, funding agencies, entrepreneurs, and the media, fewer nanoparticle (NP) technologies than expected have made it to clinical trials. The wide gap between the efforts and effective clinical translation is, at least in part, due to multiple overlooked factors in both in vitro and in vivo environments, a poor understanding of the nano-bio interface, and misinterpretation of the data collected in vitro, all of which reduce the accuracy of predictions regarding the NPs' fate and safety in humans...
March 17, 2018: Trends in Biotechnology
Yuanyuan Tao, Xiaoteng Ma, Yaqian Cai, Li Liu, Hanying Zhao
Synthesis and self-assembly of bioconjugates composed of proteins and synthetic molecules have been widely studied because of the potential applications in medicine, biotechnology and nanotechnology. One of the challenging researches in this area is to develop organic solvent-free approaches to the synthesis and self-assembly of amphiphilic bioconjugates. In this research, dialysis-assisted approach, a method based on unimer-aggregate equilibrium, was applied in the co-assembly of lysozyme and conjugate of cholesterol and glutathione (Ch-GSH)...
March 20, 2018: Journal of Physical Chemistry. B
Noam Brown, Jiangtao Lei, Chendi Zhan, Linda J W Shimon, Lihi Adler-Abramovich, Guanghong Wei, Ehud Gazit
Self-assembly is a process of key importance in natural systems and in nanotechnology. Peptides are attractive building blocks due to their relative facile synthesis, biocompatibility and other unique properties. Diphenylalanine (FF) and its derivatives are known to form nanostructures of various architectures and remarkable characteristics. The larger triphenylalanine (FFF) was found to self-assemble as efficiently as FF, forming related but distinct architectures of plate-like and spherical nanostructures...
March 20, 2018: ACS Nano
Subhashree Priyadarsini, Sumit Mukherjee, Monalisa Mishra
Nanotechnology is widely used in our day to day life including its use in medicine. Using nanotechnology, it is easy to analyze and manipulate atoms, chemical bonds and molecules present between various compounds. Nanotechnology is used in the dental field as nano dentistry. While choosing the nanoparticle for the use in the field of nano dentistry its chemical, physical, along with the biological aspect of nanostructures are taken into account. Often various atoms or molecules are added to form the functional structure...
January 2018: Journal of Oral Biology and Craniofacial Research
Emil Agocs, Ravi Kiran Attota
There has been an increasing push to derive quantitative measurements using optical microscopes. While several aspects of microscopy have been identified to enhance quantitative imaging, non-uniform angular illumination asymmetry (ANILAS) across the field-of-view is an important factor that has been largely overlooked. Non-uniform ANILAS results in loss of imaging precision and can lead to, for example, less reliability in medical diagnoses. We use ANILAS maps to demonstrate that objective lens design, illumination wavelength and location of the aperture diaphragm are significant factors that contribute to illumination aberrations...
March 19, 2018: Scientific Reports
Gustav Nyström, Mario Arcari, Raffaele Mezzenga
Chirality is ubiquitous in nature and plays crucial roles in biology, medicine, physics and materials science. Understanding and controlling chirality is therefore an important research challenge with broad implications. Unlike other chiral colloids, such as nanocellulose or filamentous viruses, amyloid fibrils form nematic phases but appear to miss their twisted form, the cholesteric or chiral nematic phases, despite a well-defined chirality at the single fibril level. Here we report the discovery of cholesteric phases in amyloids, using β-lactoglobulin fibrils shortened by shear stresses...
March 19, 2018: Nature Nanotechnology
Junko Yokota, Shojiro Kyotani
BACKGROUND: This study aims to evaluate the influence of nanoparticle size on the in vitro percutaneous penetration and retention and in vivo anti-inflammatory efficacy of percutaneously delivered non-steroidal anti-inflammatory drugs. METHODS: Indomethacin, ketoprofen and piroxicam were incorporated into nanoparticles. The nanoparticles, or the bulk-drug equivalents, were suspended in a hydrophilic ointment and compared for their ability to facilitate percutaneous drug penetration and retention in vitro...
March 16, 2018: Journal of the Chinese Medical Association: JCMA
Tuan Hiep Tran, Thi Thu Phuong Tran, Hanh Thuy Nguyen, Cao Dai Phung, Jee-Heon Jeong, Martina H Stenzel, Sung Giu Jin, Chul Soon Yong, Duy Hieu Truong, Jong Oh Kim
Crosstalk among immune cells has attracted considerable attention with the advent of immunotherapy as a novel therapeutic approach for challenging diseases, especially cancer, which is the leading cause of mortality worldwide. Dendritic cells-the key antigen-presenting cells-play a pivotal role in immunological response by presenting exogenous epitopes to T cells, which induces the self-defense mechanisms of the body. Furthermore, nanotechnology has provided promising ways for diagnosing and treating cancer in the last decade...
March 16, 2018: International Journal of Pharmaceutics
Georgia-Paraskevi Nikoleli, Dimitrios P Nikolelis, Christina G Siontorou, Stephanos Karapetis, Theo Varzakas
The modern environmental and food analysis requires sensitive, accurate, and rapid methods. The growing field of biosensors represents an answer to this demand. Unfortunately, most biosensor systems have been tested only on distilled water or buffered solutions, although applications to real samples are increasingly appearing in recent years. In this context, biosensors for potential food applications continue to show advances in areas such as genetic modification of enzymes and microorganisms, improvement of recognition element immobilization, and sensor interfaces...
2018: Advances in Food and Nutrition Research
Zhongjun Cheng, Xiaoliang Chen, Dongliang Zhai, Feiyan Gao, Tingwang Guo, Wenfeng Li, Shilei Hao, Jingou Ji, Bochu Wang
BACKGROUND: Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery. However, few reports have focused on the keratin-based mucoadhesive drug delivery system and their mechanisms of mucoadhesion. Thus, the mucoadhesion controlled kerateine (reduced keratin, KTN)/keratose (oxidized keratin, KOS) composite nanoparticles were prepared via adjusting the proportion of KTN and KOS to achieve controlled gastric mucoadhesion and drug release based on their different mucoadhesive abilities and pH-sensitive properties...
March 19, 2018: Journal of Nanobiotechnology
Sandeep Kumar Verma, Ashok Kumar Das, Manoj Kumar Patel, Ashish Shah, Vinay Kumar, Saikat Gantait
With the overwhelmingly rapid advancement in the field of nanotechnology, the engineered nanomaterials (ENMs) have been extensively used in various areas of the plant system, including quality improvement, growth and nutritional value enhancement, gene preservation etc. There are several recent reports on the ENMs' influence on growth enhancements, growth inhibition as well as certain toxic impacts on plant. However, translocation, growth responses and stress modulation mechanisms of ENMs in the plant systems call for better and in-depth understanding...
March 3, 2018: Science of the Total Environment
Zheng-Rong Lu, Peter Qiao
The treatment of malignancies has undergone dramatic changes in the past few decades. Advances in drug delivery techniques and nanotechnology have allowed for new formulations of old drugs, so as to improve the pharmacokinetics, to enhance accumulation in solid tumors, and to reduce the significant toxic effects of these important therapeutic agents. Here, we review the published clinical data in cancer therapy of several major drug delivery systems, including targeted radionuclide therapy, antibody drug conjugates, liposomes, polymer drug conjugates, polymer implants, micelles, and nanoparticles...
March 19, 2018: Molecular Pharmaceutics
Chen Fu, Chizhu Ding, Xianchao Sun, Ailing Fu
Nanotechnology plays an important role in the development of drug delivery, imaging, and diagnosis. In this study, nanocapsules containing protein-functionalized gold nanoclusters (AuNCs) as the shell and hydrophobic drug curcumin as the core were prepared as a tumor cell theranostic agent. After the nanocapsules were added into tumor cell media, they entered the cells with high efficiency and exhibited strong fluorescence within the cells. The results indicated that the nanocapsules were broken up in the cells and curcumin was released...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Zeinab Haghparasti, Mahnaz Mahdavi Shahri
The use of nontoxic biological compounds in the synthesis of nanomaterials is an ecofriendly and cost-effective approach in nanotechnology. The present work was carried out to develop silver nanoparticles (Ag-NPs) by a green method using white tea (Wt) extract as reducing agent for reduction of silver nitrate as silver precursor into the lamellar space of inorganic polymer montmorillonite (Mt) as an effective protective reagent and support as well. The bioformed Wt/Ag@Mt nanocomposite (NCs) was compared with pure biosynthesized Wt/Ag-NPs under free stabilizer condition and effect of Mt stabilizer on antioxidant, cytotoxicity and structural properties were also investigated...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Kehu Zhang, Jiangtao Liu, Yinzhou Guo, Yan Li, Xiao Ma, Zhongli Lei
Herein, we prepared a novel quintuple-stimuli-responsive shell-crosslinked (SCL) nanocontainer in respond to temperature, pH, light, and oxidation or reduction species. The well-defined amphiphilic diblock copolymer poly(2-methacryloyloxyethyl ferrocenecarboxylate)-(5-propargylether-2-nitrobenzyl bromoisobutyrate)-poly(dimethylaminoethyl methacrylate) (PMAEFc-ONB-PDMAEMA) was synthesized via atom transfer radical polymerization (ATRP) and click chemistry. The diblock copolymer self-assembled into spherical micelles with a uniform size in aqueous media as non-crosslinked (NCL) micelles, and then the micelles were crosslinked by N,N'-bis(bromoacetyl) cystamine (BBAC) through quaternization reaction between the nitrogen of DMAEMA and the bromine of BBAC to receive the SCL micelles which shrunk at higher temperature, swelled at acidic pH or a low concentration of hydrogen peroxide (H2 O2 ), decrosslinked by a small amount of DL-dithiothreitol (DTT), and were disrupted with DTT and UV light...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Jennifer Gubitosa, Vito Rizzi, Angela Lopedota, Paola Fini, Anna Laurenzana, Gabriella Fibbi, Fiorenza Fanelli, Andrea Petrella, Valentino Laquintana, Nunzio Denora, Roberto Comparelli, Pinalysa Cosma
HYPOTHESIS: The interesting properties of Gold Nanoparticles (AuNPs) make them attractive for different application fields such as cosmetology, medicine and clinical nanotechnologies. In this work a fast, easy and eco-friendly method for the AuNPs synthesis is proposed by using the Punica Granatum Juice (PGJ) with potential dermatological and cosmetic applications. The AuNPs antioxidant activity, due to the presence of phenols from the juice, and their use as booster for improving the Sun Protection Factor (SPF) in commercial sunscreen formulations, are thus expounded...
March 9, 2018: Journal of Colloid and Interface Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"