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https://www.readbyqxmd.com/read/28937916/nanoparticles-for-advanced-photodynamic-therapy-of-cancer
#1
Heidi Abrahamse, Cherie Ann Kruger, Sania Kadanyo, Ajay Mishra
The world widespread rise in cancer incidence has caused an increase in the demand for effective and safe materials for treatment. One of the most prevalent forms of treatment for cancer is photodynamic therapy (PDT), which is seen as an alternative to radiotherapy, as well as chemotherapy. In more recent years, researchers are exploring new nanotechnology-based strategies to improve the effectiveness of PDT. OBJECTIVE: The objective of this review is to explore the current trends and research findings associated with PDT and the development of nanotechnology as treatment modality for cancer...
September 21, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28936523/mesoporous-zno-nanocapsules-for-the-induction-of-enhanced-antigen-specific-immunological-responses
#2
Sumbul Afroz, Himadri Medhi, Somedutta Maity, Gillipsie Minhas, Srikanth Battu, Jeevan Giddaluru, Koushi Kumar, Pradip Paik, Nooruddin Khan
The application of nanotechnology in vaccinology has fuelled rapid advancement towards the design and development of nanovaccines. Nanoparticles have been found to enhance vaccine efficacy through the spatiotemporal orchestration of antigen delivery to secondary lymphoid organs and antigen-presentation by Antigen Presenting Cells (APCs) synchronized with stimulation of innate and adaptive immune responses. Metal based nanoparticles (MNPs) have been extensively engineered for the generation of nanovaccines owing to their intrinsic adjuvant-like properties and immunomodulatory functions...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28933862/creim-coffee-ring-effect-imaging-model-for-monitoring-protein-self-assembly-in-situ
#3
Michael Shaw, Angelo Bella, Maxim G Ryadnov
Protein self-assembly is fundamental to nanotechnology. Self-assembling structures are produced under static in vitro conditions typically forming over hours. In contrast, hydrodynamic intracellular environments employ far shorter time scales to compartmentalize highly concentrated protein solutions. Herein, we exploit the radial capillary flow within a drying sessile droplet (the coffee ring effect) to emulate dynamic native environments and monitor an archetypal protein assembly in situ using high-speed super-resolution imaging...
September 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28933820/considerations-for-safe-innovation-the-case-of-graphene
#4
Margriet V D Z Park, Eric A J Bleeker, Walter Brand, Flemming R Cassee, Merel van Elk, Ilse Gosens, Wim H De Jong, Johannes A J Meesters, Willie Jgm Peijnenburg, Joris T K Quik, Rob J Vandebriel, Adrienne J A M Sips
The terms 'Safe innovation' and 'Safe(r)-by-design' are currently popular in the field of nanotechnology. These terms are used to describe approaches that advocate the consideration of safety aspects already at an early stage of the innovation process of (nano)materials and nano-enabled products. Here, we investigate the possibilities of considering safety aspects during various stages of the innovation processes based on of graphene, outlining what information is already available for assessing potential hazard, exposure and risks...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28933435/nanotechnology-a-molecular-assembler
#5
T Ross Kelly, Marc L Snapper
No abstract text is available yet for this article.
September 20, 2017: Nature
https://www.readbyqxmd.com/read/28933296/inflammation-and-cancer-in-medio-stat-nano
#6
Roberto Molinaro, Claudia Corbo, Megan Livingston, Michael Evangelopoulos, Alessandro Parodi, Christian Boada, Marco Agostini, Ennio Tasciotti
Cancer treatment still remains a challenge due to the several limitations of currently used chemotherapeutics, such as their poor pharmacokinetics, unfavorable chemical properties, as well as inability to discriminate between healthy and diseased tissue. Nanotechnology offered potent tools to overcome these limitations. Drug encapsulation within a delivery system permitted i) to protect the payload from enzymatic degradation/inactivation in the blood stream, ii) to improve the physicochemical properties of poorly water-soluble drugs, like paclitaxel, and iii) to selectively deliver chemotherapeutics to the cancer lesions, thus reducing the off-target toxicity, and promoting the intracellular internalization...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933284/enzyme-instructed-self-assembly-in-biological-milieu-for-theranostics-purpose
#7
Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen, Yuan Gao
Precision medicine is in an urgent need for public healthcare. Among the past several decades, the flourishing development in nanotechnology significantly advances the realization of precision nanomedicine. Comparing to well-documented nanoparticle-based strategy, in this review we focus on the strategy using enzyme instructed self-assembly (EISA) in biological milieu for theranostics purpose. In principle, the design of small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest; (2) self-assembly potency after enzymatic conversion...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933183/an-update-on-nanoparticle-based-contrast-agents-in-medical-imaging
#8
Neda Naseri, Elham Ajorlou, Fatemeh Asghari, Younes Pilehvar-Soltanahmadi
Despite the great value of current exogenous contrast agents for providing main diagnostic information, they still have certain drawbacks such as short blood half life, nonspecific biodistribution, fast clearance, slight renal toxicity and poor contrast in fat patients. Nanoparticles (NPs) are used as novel contrast agents that represent a promising strategy for the non invasive diagnosis. As a platform, nanoparticulates are compatible for developing targeted contrast agents. Advances in nanotechnology will provide enhanced sensitivity and specificity for tumor imaging enabling earlier detection of metastases...
September 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28932494/nanotechnology-advancing-the-translational-respiratory-research
#9
Kamal Dua, Shakti Dhar Shukla, Terezinha de Jesus Andreoli Pinto, Philip Michael Hansbro
Considering the various limitations associated with the conventional dosage forms, nanotechnology is gaining increased attention in drug delivery particularly in respiratory medicine and research because of its advantages like targeting effects, improved pharmacotherapy, and patient compliance. This paper provides a quick snapshot about the recent trends and applications of nanotechnology to various translational and formulation scientists working on various respiratory diseases, which can help paving a new path in developing effective drug delivery system...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28931204/preface-to-forum-on-block-copolymers-for-nanotechnology-applications
#10
Peter Müller-Buschbaum
No abstract text is available yet for this article.
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28930989/demonstration-of-a-hyperlens-integrated-microscope-and-super-resolution-imaging
#11
Dasol Lee, Minkyung Kim, Sunae So, Inki Kim, Gwanho Yoon, Kyunghoon Kim, Junsuk Rho
The use of super-resolution imaging to overcome the diffraction limit of conventional microscopy has attracted the interest of researchers in biology and nanotechnology. Although near-field scanning microscopy and superlenses have improved the resolution in the near-field region, far-field imaging in real-time remains a significant challenge. Recently, the hyperlens, which magnifies and converts evanescent waves into propagating waves, has emerged as a novel approach to far-field imaging. Here, we report the fabrication of a spherical hyperlens composed of alternating silver (Ag) and titanium oxide (TiO2) thin layers...
September 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930588/nanoparticles-in-wound-healing-from-hope-to-promise-from-promise-to-routine
#12
Naghmeh Naderi, Dimitrios Karponis, Afshin Mosahebi, Alexander M Seifalian
Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930584/metal-and-metalloid-containing-drugs-for-the-treatment-of-trypanosomatid-diseases
#13
Gianni Colotti, Annarita Fiorillo, Andrea Ilari
The trypanosomatid-induced diseases are considered as neglected, because the countries where they kill people are not important markets for western big pharmaceutical companies. However, recently some effort has been made to translate the use of already known drugs to neglected infectious disease. Although many metals are essential to life, many disorders affecting metal homeostasis and bioavailability are responsible for several human diseases. Metals can be toxic even at very low concentrations and semimetals are classified as toxic and dangerous for the environment...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28928662/toxicity-of-nanoparticles-on-the-reproductive-system-in-animal-models-a-review
#14
REVIEW
Rahim Dad Brohi, Li Wang, Hira Sajjad Talpur, Di Wu, Farhan Anwar Khan, Dinesh Bhattarai, Zia-Ur Rehman, F Farmanullah, Li-Jun Huo
In the last two decades, nanotechnologies demonstrated various applications in different fields, including detection, sensing, catalysis, electronics, and biomedical sciences. However, public concerns regarding the well-being of human may hinder the wide utilization of this promising innovation. Although, humans are exposed to airborne nanosized particles from an early age, exposure to such particles has risen dramatically within the last century due to anthropogenic sources of nanoparticles. The wide application of nanomaterials in industry, consumer products, and medicine has raised concerns regarding the potential toxicity of nanoparticles in humans...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28928405/nanopore-extended-field-effect-transistor-for-selective-single-molecule-biosensing
#15
Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P Ivanov, Joshua B Edel, Yuri Korchev
There has been a significant drive to deliver nanotechnological solutions to biosensing, yet there remains an unmet need in the development of biosensors that are affordable, integrated, fast, capable of multiplexed detection, and offer high selectivity for trace analyte detection in biological fluids. Herein, some of these challenges are addressed by designing a new class of nanoscale sensors dubbed nanopore extended field-effect transistor (nexFET) that combine the advantages of nanopore single-molecule sensing, field-effect transistors, and recognition chemistry...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927549/improved-threshold-selection-for-the-determination-of-volume-of-distribution-of-nanoparticles-administered-by-convection-enhanced-delivery
#16
David Lei Chi, Eric Song, Alice Gaudin, W Mark Saltzman
Nanotechnology, in conjunction with convection-enhanced delivery (CED), has gained traction as a promising method to treat many debilitating neurological diseases, including gliomas. One of the key parameters to evaluate the effectiveness of delivery is the volume of distribution (Vd) of nanoparticles within the brain parenchyma. Measurements of Vd are commonly made using fluorescent reporter systems. However, reported analyses lack accurate and robust methods for determining Vd. Current methods face the problems of varying background intensities between images, high intensity aggregates that can shift intensity distributions, and faint residual backgrounds that can occur as artifacts of fluorescent imaging...
August 24, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28926073/pore-and-ligament-size-control-thermal-stability-and-mechanical-properties-of-nanoporous-single-crystals-of-gold
#17
Maria Koifman Khristosov, Shiri Dishon, Imrit Noi, Alex Katsman, Boaz Pokroy
Nanoporous gold is widely used in research and nanotechnology because of its diverse properties, including high surface area and catalytic activity. The ligament size is usually considered as one of the main parameters controlling thermal stability and mechanical properties of nanoporous gold. Recently we developed a method for creating nanoporous single crystal gold particles using eutectic decomposition of Au-Ge, followed by selective etching of Ge. Here, we used this novel method to create nanoporous gold particles with controlled ligament sizes by changing the initial sample's relative concentrations of gold and germanium...
September 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28925946/development-and-biocompatibility-evaluation-of-photocatalytic-tio%C3%A2-reduced-graphene-oxide-based-nanoparticles-designed-for-self-cleaning-purposes
#18
Ionela Cristina Nica, Miruna S Stan, Marcela Popa, Mariana Carmen Chifiriuc, Gratiela G Pircalabioru, Veronica Lazar, Iuliana Dumitrescu, Lucian Diamandescu, Marcel Feder, Mihaela Baibarac, Marin Cernea, Valentin Adrian Maraloiu, Traian Popescu, Anca Dinischiotu
Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO₂, but the development of TiO₂/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO₂ particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti(3+) and Fe(3+) ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface...
September 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28925905/nanomedicine-in-the-diagnosis-and-treatment-of-atherosclerosis-a-systematic-review
#19
Kannan Vaidyanathan, Sandhya Gopalakrishnan
BACKGROUND: Atherosclerosis is a chronic inflammatory condition causing very high morbidity and mortality. It is characterized by accumulation of plaques within arteries. Nanomedicine is an emerging field of medicine utilizing nanotechnology for advanced imaging and therapy. Nanomedicine has led to significant developments in the field of cardiovascular diseases, including atherosclerosis. Many nanoformulations have been developed with anti-atherosclerotic effects. Nanomedicine tools have been used in the imaging of atherosclerosis...
September 18, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28924348/single-walled-carbon-nanotubes-ciprofloxacin-nanoantibiotic-strategy-to-improve-ciprofloxacin-antibacterial-activity
#20
Mohyeddin Assali, Abdel Naser Zaid, Farah Abdallah, Motasem Almasri, Rasha Khayyat
As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis...
2017: International Journal of Nanomedicine
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