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Zinc homeostasis

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https://www.readbyqxmd.com/read/29142255/a-nonredundant-role-for-the-trpm6-channel-in-neural-tube-closure
#1
Yuko Komiya, Zhiyong Bai, Na Cai, Liping Lou, Namariq Al-Saadi, Courtney Mezzacappa, Raymond Habas, Loren W Runnels
In humans, germline mutations in Trpm6 cause autosomal dominant hypomagnesemia with secondary hypocalcemia disorder. Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally results in early embryonic lethality and neural tube closure defects. To define the mechanisms by which TRPM6 influences neural tube closure, we functionally characterized the role of TRPM6 during early embryogenesis in Xenopus laevis. The expression of Xenopus TRPM6 (XTRPM6) is elevated at the onset of gastrulation and is concentrated in the lateral mesoderm and ectoderm at the neurula stage...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137144/impact-of-labile-zinc-on-heart-function-from-physiology-to-pathophysiology
#2
REVIEW
Belma Turan, Erkan Tuncay
Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn(2+). Although Zn(2+) concentration is in the nM range in cardiomyocytes at rest and increases dramatically under stimulation, very little is known about precise mechanisms controlling the intracellular distribution of Zn(2+) and its variations during cardiac function. Recent studies are focused on molecular and cellular aspects of labile Zn(2+) and its homeostasis in mammalian cells and growing evidence clarified the molecular mechanisms underlying Zn(2+)-diverse functions in the heart, leading to the discovery of novel physiological functions of labile Zn(2+) in parallel to the discovery of subcellular localization of Zn(2+)-transporters in cardiomyocytes...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133823/identification-of-mirna-mediated-drought-responsive-multi-tiered-regulatory-network-in-drought-tolerant-rice-nagina-22
#3
Sonia Balyan, Mukesh Kumar, Roseeta Devi Mutum, Utkarsh Raghuvanshi, Priyanka Agarwal, Saloni Mathur, Saurabh Raghuvanshi
Comparative characterization of microRNA-mediated stress regulatory networks in contrasting rice cultivars is critical to decipher plant stress response. Consequently, a multi-level comparative analysis, using sRNA sequencing, degradome analysis, enzymatic and metabolite assays and metal ion analysis, in drought tolerant and sensitive rice cultivars was conducted. The study identified a group of miRNAs "Cultivar-specific drought responsive" (CSDR)-miRNAs (osa-miR159f, osa-miR1871, osa-miR398b, osa-miR408-3p, osa-miR2878-5p, osa-miR528-5p and osa-miR397a) that were up-regulated in the flag-leaves of tolerant cultivar, Nagina 22 (N22) and Vandana, but down-regulated in the sensitive cultivar, Pusa Basmati 1 (PB1) and IR64, during drought...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116164/zinc-enhances-the-cellular-energy-supply-to-improve-cell-motility-and-restore-impaired-energetic-metabolism-in-a-toxic-environment-induced-by-ota
#4
Xuan Yang, Haomiao Wang, Chuchu Huang, Xiaoyun He, Wentao Xu, Yunbo Luo, Kunlun Huang
Exogenous nutrient elements modulate the energetic metabolism responses that are prerequisites for cellular homeostasis and metabolic physiology. Although zinc is important in oxidative stress and cytoprotection processes, its role in the regulation of energetic metabolism remains largely unknown. In this study, we found that zinc stimulated aspect in cell motility and was essential in restoring the Ochratoxin A (OTA)-induced energetic metabolism damage in HEK293 cells. Moreover, using zinc supplementation and zinc deficiency models, we observed that zinc is conducive to mitochondrial pyruvate transport, oxidative phosphorylation, carbohydrate metabolism, lipid metabolism and ultimate energy metabolism in both normal and toxic-induced oxidative stress conditions in vitro, and it plays an important role in restoring impaired energetic metabolism...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109727/dexamethasone-and-monophosphoryl-lipid-a-induce-a-distinctive-profile-on-monocyte-derived-dendritic-cells-through-transcriptional-modulation-of-genes-associated-with-essential-processes-of-the-immune-response
#5
Paulina A García-González, Katina Schinnerling, Alejandro Sepúlveda-Gutiérrez, Jaxaira Maggi, Ahmed M Mehdi, Hendrik J Nel, Bárbara Pesce, Milton L Larrondo, Octavio Aravena, María C Molina, Diego Catalán, Ranjeny Thomas, Ricardo A Verdugo, Juan C Aguillón
There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a tolerogenic state are still poorly understood. Here, we studied the transcriptional profile of moDCs from healthy subjects, modulated with dexamethasone (Dex) and activated with monophosphoryl lipid A (MPLA), referred to as Dex-modulated and MPLA-activated DCs (DM-DCs), as an approach to identify molecular regulators and pathways associated with the induction of tolerogenic properties in tolDCs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29101379/the-structural-basis-of-proton-driven-zinc-transport-by-zntb
#6
Cornelius Gati, Artem Stetsenko, Dirk J Slotboom, Sjors H W Scheres, Albert Guskov
Zinc is an essential microelement to sustain all forms of life. However, excess of zinc is toxic, therefore dedicated import, export and storage proteins for tight regulation of the zinc concentration have evolved. In Enterobacteriaceae, several membrane transporters are involved in zinc homeostasis and linked to virulence. ZntB has been proposed to play a role in the export of zinc, but the transport mechanism of ZntB is poorly understood and based only on experimental characterization of its distant homologue CorA magnesium channel...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29100100/link-of-impaired-metal-ion-homeostasis-to-mitochondrial-dysfunction-in-neurons
#7
REVIEW
Eunju Nam, Jiyeon Han, Jong-Min Suh, Yelim Yi, Mi Hee Lim
Manganese, iron, copper, and zinc are observed to play essential roles in mitochondria. The overload and depletion of metal ions in mitochondria under pathological conditions, however, could disturb mitochondrial compartments and functions leading to cell death. In this review, we mainly summarize how impaired metal ion homeostasis affects mitochondrial systems, such as membrane potentials, the tricarboxylic acid cycle, oxidative phosphorylation, and glutathione metabolism. In addition, based on current findings, we briefly describe a recent understanding of the relationship among metal ion dysregulation, mitochondrial dysfunction, and the pathogeneses of neurodegenerative diseases...
October 27, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29092635/hydrogen-sulfide-ameliorates-zinc-induced-cell-death-in-neuroblastoma-sh-sy5y-cells
#8
Megumi Shimoji, Hirokazu Hara, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Previous reports have demonstrated that excess zinc (Zn(2+)) released from nerve terminals following cerebral ischemia causes brain injury. Therefore, disturbance of Zn(2+) homeostasis in the brain is thought to be closely linked to neurotoxicity. Recently, hydrogen sulfide (H2S), a gaseous mediator, has been reported to ameliorate ischemic brain injury. However, its mechanism is not fully understood. In this study, we examined whether sodium hydrogen sulfide (NaHS), an H2S donor, protects against Zn(2+) cytotoxicity using human neuroblastoma SH-SY5Y cells...
November 1, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29081021/life-and-death-of-trypanosoma-cruzi-in-presence-of-metals
#9
Laís Pessanha de Carvalho, Edésio José Tenório de Melo
Trypanosoma cruzi has many molecules that need metallic elements to work, allowing cell invasion and the establishment of infection, causing Chagas disease. Nonetheless, knowledge regarding how the parasites address metals and maintain homeostasis is lacking. To study this relationship, zinc, cadmium and mercury were chosen. Epimastigote, trypomastigote and intracellular forms of T. cruzi were incubated with these metals for different times and at different concentrations. In general, epimastigotes were the most sensitive and trypomastigotes the most resistant to metals...
October 28, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29078349/requirement-of-zinc-transporter-zip10-for-epidermal-development-implication-of-the-zip10-p63-axis-in-epithelial-homeostasis
#10
Bum-Ho Bin, Jinhyuk Bhin, Mikiro Takaishi, Koh-Ei Toyoshima, Saeko Kawamata, Kana Ito, Takafumi Hara, Takashi Watanabe, Tarou Irié, Teruhisa Takagishi, Su-Hyon Lee, Haeng-Sun Jung, Sangchul Rho, Juyeon Seo, Dong-Hwa Choi, Daehee Hwang, Haruhiko Koseki, Osamu Ohara, Shigetoshi Sano, Takashi Tsuji, Kenji Mishima, Toshiyuki Fukada
Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29074370/the-zinc-finger-protein-cg12744-is-essential-for-differentiation-and-regeneration-after-infection-in-the-adult-drosophila-midgut
#11
Qiang Liu, Li Hua Jin
Pluripotent stem cell activity is essential to maintain regeneration and homeostasis in the Drosophila midgut following environmental challenges. Although multiple pathways have been implicated in epithelial renewal, the underlying regulatory mechanisms and correlations between relevant genes and pathways remain elusive. In this study, we show that the zinc finger protein CG12744 plays an important role in the differentiation and regeneration of epithelial cells in response to oral infection with Erwinia carotovora carotovora 15...
October 23, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29072367/reappraisal-of-metallothionein-clinical-implications-for-patients-with-diabetes-mellitus
#12
REVIEW
Yongsoo Park, Jian Zhang, Lu Cai
Reactive oxygen and nitrogen species (ROS/RNS) are by-products of cellular physiological processes made from the metabolisms of intermediary nutrients. Although physiological defense mechanisms readily convert these species into water or urea, improper balance between their production and removal leads cells to experience oxidative stress (OS), which is harmful to cellular components. This may result in uncontrolled growth or ultimately to cell death. ROS/RNS are also closely related to the development of diabetes and its complications...
October 26, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29065550/metallothioneins-emerging-modulators-in-immunity-and-infection
#13
REVIEW
Kavitha Subramanian Vignesh, George S Deepe
Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. In recent years, MTs have emerged as an important, yet largely underappreciated, component of the immune system. Innate and adaptive immune cells regulate MTs in response to stress stimuli, cytokine signals and microbial challenge...
October 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29064429/zinc-signals-and-immunity
#14
REVIEW
Martina Maywald, Inga Wessels, Lothar Rink
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency as well as zinc excess result in severe disturbances in immune cell numbers and activities, which can result in increased susceptibility to infections and development of especially inflammatory diseases. This review focuses on the role of zinc in regulating intracellular signaling pathways in innate as well as adaptive immune cells. Main underlying molecular mechanisms and targets affected by altered zinc homeostasis, including kinases, caspases, phosphatases, and phosphodiesterases, will be highlighted in this article...
October 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29062896/copper-chaperone-cupa-and-zinc-control-copy-regulation-of-the-pneumococcal-cop-operon
#15
Miranda J Neubert, Elizabeth A Dahlmann, Andrew Ambrose, Michael D L Johnson
Any metal in excess can be toxic; therefore, metal homeostasis is critical to bacterial survival. Bacteria have developed specialized metal import and export systems for this purpose. For broadly toxic metals such as copper, bacteria have evolved only export systems. The copper export system (cop operon) usually consists of the operon repressor, the copper chaperone, and the copper exporter. In Streptococcus pneumoniae, the causative agent of pneumonia, otitis media, sepsis, and meningitis, little is known about operon regulation...
September 2017: MSphere
https://www.readbyqxmd.com/read/29057818/chronic-high-dose-zinc-supplementation-induces-visceral-adipose-tissue-hypertrophy-without-altering-body-weight-in-mice
#16
Xiaohua Huang, Dandan Jiang, Yingguo Zhu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Jian Li, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu, Bin Feng
The trace element zinc plays an important role in human life. Zinc deficiency impairs growth, reproduction, metabolism and immunity in both human and animals. Thus, zinc supplementation is recommended in daily life. However, the effect of long-term chronic zinc supplementation on adipose homeostasis has not been well elucidated. In the current study, mice were supplemented with zinc sulfate in the drinking water for 20 weeks. The results suggested that chronic zinc supplementation impaired systemic glucose clearance after exogenous insulin or glucose challenges, as compared to the control mice...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29053582/zinc-supplementation-improves-glucose-homeostasis-in-high-fat-fed-mice-by-enhancing-pancreatic-%C3%AE-cell-function
#17
Vinícius Cooper-Capetini, Diogo Antonio Alves de Vasconcelos, Amanda Roque Martins, Sandro Massao Hirabara, José Donato, Angelo Rafael Carpinelli, Fernando Abdulkader
Zinc is an essential component of the insulin granule and it possibly modulates insulin secretion and signaling. Since insulin resistance is a hallmark in the development of type 2 diabetes mellitus, this study aimed at investigating if zinc supplementation is able to improve glucose tolerance and β-cell function in a model of insulin resistance. Male C57BL/6 mice were distributed in four groups according to the diet: normal fat (NF); normal fat supplemented with ZnCl₂ (NFZ); high-fat (HF); and, high-fat chow supplemented with ZnCl₂ (HFZ)...
October 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29048339/understanding-the-contribution-of-zinc-transporters-in-the-function-of-the-early-secretory-pathway
#18
REVIEW
Taiho Kambe, Mayu Matsunaga, Taka-Aki Takeda
More than one-third of newly synthesized proteins are targeted to the early secretory pathway, which is comprised of the endoplasmic reticulum (ER), Golgi apparatus, and other intermediate compartments. The early secretory pathway plays a key role in controlling the folding, assembly, maturation, modification, trafficking, and degradation of such proteins. A considerable proportion of the secretome requires zinc as an essential factor for its structural and catalytic functions, and recent findings reveal that zinc plays a pivotal role in the function of the early secretory pathway...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29047263/cross-talk-between-phosphate-starvation-and-other-environmental-stress-signaling-pathways-in-plants
#19
REVIEW
Dongwon Baek, Hyun Jin Chun, Dae-Jin Yun, Min Chul Kim
The maintenance of inorganic phosphate (Pi) homeostasis is essential for plant growth and yield. Plants have evolved strategies to cope with Pi starvation at the transcriptional, post-transcriptional, and post-translational levels, which maximizes its availability. Many transcription factors, miRNAs, and transporters participate in the Pi starvation signaling pathway where their activities are modulated by sugar and phytohormone signaling. Environmental stresses significantly affect the uptake and utilization of nutrients by plants, but their effects on the Pi starvation response remain unclear...
October 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29045571/zinc-induced-metallothionein-in-centenarian-offspring-from-a-large-european-population-the-mark-age-project
#20
Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Alexander Bürkle, Maria Moreno-Villanueva, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Claudio Franceschi, Antti Hervonen, Eline Slagboom, Fabio Ciccarone, Michele Zampieri, Paola Caiafa, Eugène Jansen, Martijn E T Dollé, Nicolle Breusing, Eugenio Mocchegiani, Marco Malavolta
Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO)...
October 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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