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Zinc homeostasis

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https://www.readbyqxmd.com/read/29321173/an-autophagy-independent-role-for-atg41-in-sulfur-metabolism-during-zinc-deficiency
#1
Michael D Bucci, Erin Weisenhorn, Spencer Haws, Zhiyuan Yao, Ginelle Zimmerman, Molly Gannon, Janet Taggart, Traci Lee, Daniel J Klionsky, Jason Russell, Joshua Coon, David J Eide
The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41 Here, we report that Atg41 is required for growth in zinc-deficient conditions but not when zinc is abundant or when other metals are limiting. Consistent with a role for Atg41 in macroautophagy, we show that nutritional zinc deficiency induces autophagy and that mutation of ATG41 diminishes that response...
January 10, 2018: Genetics
https://www.readbyqxmd.com/read/29307143/prediction-of-metal-ion-binding-sites-in-proteins-from-amino-acid-sequences-by-using-simplified-amino-acid-alphabets-and-random-forest-model
#2
Suresh Kumar
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis. In structural genomics, prediction of metal binding proteins help in the selection of suitable growth medium for overexpression's studies and also help in obtaining the functional protein. Computational prediction using machine learning approach has been widely used in various fields of bioinformatics based on the fact all the information contains in amino acid sequence...
December 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/29287786/leptin-treatment-prevents-long-term-abnormalities-in-cognition-seizure-threshold-hippocampal-mossy-fiber-sprouting-and-znt3-cb-d28k-expression-in-a-rat-developmental-twist-seizure-model
#3
Hong Ni, Su-Hong Chen, Li-Li Li, Mei-Fang Jin
The mechanism of linking neonatal seizures with long-term brain damage is unclear, and there is no effective drug to block this long-term pathological process. Recently, the fat-derived hormone leptin has been appreciated for its neuroprotective function in neurodegenerative processes, although less is known about the effects of leptin on neonatal seizure-induced brain damage. Here, we developed a "twist" seizure model by coupling pilocarpine-induced neonatal status epilepticus (SE) with later exposure to penicillin to test whether leptin treatment immediately after neonatal SE would exert neuroprotective effects on cognition, seizure threshold and hippocampal mossy fiber sprouting, as well if leptin had any influence on the expression of zinc transporter 3 (ZnT3) and calcium homeostasis-related CB-D28k in the hippocampus...
December 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29284678/the-cue1-domain-of-the-snf2-like-chromatin-remodeler-smarcad1-mediates-its-association-with-krab-associated-protein-1-kap1-and-kap1-target-genes
#4
Dong Ding, Philipp Bergmaier, Parysatis Sachs, Marius Klangwart, Tamina Rückert, Nora Bartels, Jeroen Demmers, Mike Dekker, Raymond A Poot, Jacqueline E Mermoud
Chromatin in embryonic stem cells (ESCs) differs markedly from that in somatic cells, with ESCs exhibiting a more open chromatin configuration. Accordingly, ATP-dependent chromatin remodeling complexes are important regulators of ESC homeostasis. Depletion of the remodeler SMARCAD1, an ATPase of the SNF2 family, has been shown to affect stem cell state, but the mechanistic explanation for this effect is unknown. Here, we set out to gain further insights into the function of SMARCAD1 in mouse ESCs. We identified KRAB-associated protein 1 (KAP1) as the stoichiometric binding partner of SMARCAD1 in ESCs...
December 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29280652/dietary-intake-and-zinc-status-in-amyotrophic-lateral-sclerosis-patients
#5
Heloisa Fernanda Lopes da Silva, Acsa Nara Araújo Brito, Erika Paula Silva de Freitas, Mário Emílio Teixeira Dourado, Karine Cavalcanti Maurício Sena-Evangelista, Lucia Leite Lais
BACKGROUND: There is considerable evidence that abnormal zinc homeostasis is related to amyotrophic lateral sclerosis (ALS) pathogenesis, and malnutrition is an independent prognostic factor for worsened survival of ALS patients. OBJECTIVE: To evaluate the dietary intake and zinc status in patients with ALS, treated in a specialized outpatient facility in Natal, Brazil. METHODS: Twenty patients with ALS (case group) and 37 healthy subjects (control group) were included...
October 27, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29275290/genetically-encoded-fluorescent-sensors-for-measuring-transition-and-heavy-metals-in-biological-systems
#6
REVIEW
Ziyang Hao, Rongfeng Zhu, Peng R Chen
Great progress has been made in expanding the repertoire of genetically encoded fluorescent sensors for monitoring intracellular transition metals (TMs). This powerful toolkit permits dynamic and non-invasive detection of TMs with high spatial-temporal resolution, which enables us to better understand the roles of TM homeostasis in both physiological and pathological settings. Here we summarize the recent development of genetically encoded fluorescent sensors for intracellular detection of TMs such as zinc and copper, as well as heavy metals including lead, cadmium, mercury, and arsenic...
December 21, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29250721/annotation-and-characterization-of-cd-responsive-metal-transporter-genes-in-rapeseed-brassica-napus
#7
Xian Duo Zhang, Jin Guo Meng, Kai Xuan Zhao, Xi Chen, Zhi Min Yang
In higher plants, heavy metal transporters are responsible for metal uptake, translocation and homeostasis. These metals include essential metals such as zinc (Zn) or manganese (Mn) and non-essential metals like cadmium (Cd) or lead (Pb). Although a few heavy metal transporters have been well identified in model plants (e.g. Arabidopsis and rice), little is known about their functionality in rapeseed (Brassica napus). B. napus is an important oil crop ranking the third largest sources of vegetable oil over the world...
December 18, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29247123/taurine-chloramine-potentiates-phagocytic-activity-of-peritoneal-macrophages-through-up-regulation-of-dectin-1-mediated-by-heme-oxygenase-1-derived-carbon-monoxide
#8
Seung Hyeon Kim, Xiancai Zhong, Wonki Kim, Kyeojin Kim, Young-Ger Suh, Chaekyun Kim, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Surh
Resolution of inflammation that occurs after microbial infection or tissue damage is an important physiologic process in maintaining or restoring host homeostasis. Taurine chloramine (TauCl) is formed by a reaction between taurine and hypochlorite in leukocytes, and it is especially abundant in activated neutrophils that encounter an oxidative burst. As neutrophils undergo apoptosis, TauCl is released to the extracellular matrix at the inflamed sites, thereby affecting coexisting macrophages in the inflammatory microenvironment...
December 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29244031/transition-and-post-transition-metals-in-exhaled-breath-condensate
#9
Andrew Ghio, Michael C Madden, Charles R Esther
Water vapor in expired air, as well as dispersed non-volatile components, condense onto a cooler surface after exiting the respiratory tract. This exhaled breath condensate (EBC) provides a dilute sampling of the epithelial lining fluid. Accordingly, the collection of EBC imparts a capacity to provide biomarkers of injury preceding clinical disease. Concentrations of transition and post-transition metals in EBC are included among these endpoints. Iron and zinc are those metals in highest concentration and are measurable in all EBC samples from healthy subjects; other metals are most frequently either at or below the level of detection in this group...
December 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29243032/zinc-transporter-proteins
#10
REVIEW
Abdulkerim Kasim Baltaci, Kemal Yuce
Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes...
December 14, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29239069/the-antiviral-role-of-zinc-and-metallothioneins-in-hepatitis-c-infection
#11
Scott A Read, Grant Parnell, David Booth, Mark W Douglas, Jacob George, Golo Ahlenstiel
Metallothioneins (MTs) are small, cysteine rich proteins characterized by a high affinity for monovalent and divalent cations, such as copper and zinc. Of the four known metallothionein isoforms, only members of the metallothionein 1 and 2 subfamilies are widely expressed, acting as metal chaperones whose primary role is to mediate intracellular zinc homeostasis. Metallothioneins are potently induced by heavy metals and other sources of oxidative stress where they facilitate metal binding and detoxification as well as free radical scavenging...
December 14, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29236063/recent-advances-in-the-role-of-slc39a-zip-zinc-transporters-in-vivo
#12
REVIEW
Teruhisa Takagishi, Takafumi Hara, Toshiyuki Fukada
Zinc (Zn), which is an essential trace element, is involved in numerous mammalian physiological events; therefore, either a deficiency or excess of Zn impairs cellular machineries and influences physiological events, such as systemic growth, bone homeostasis, skin formation, immune responses, endocrine function, and neuronal function. Zn transporters are thought to mainly contribute to Zn homeostasis within cells and in the whole body. Recent genetic, cellular, and molecular studies of Zn transporters highlight the dynamic role of Zn as a signaling mediator linking several cellular events and signaling pathways...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29234311/the-slzrt1-gene-encodes-a-plasma-membrane-located-zip-zrt-irt-like-protein-transporter-in-the-ectomycorrhizal-fungus-suillus-luteus
#13
Laura Coninx, Anneleen Thoonen, Eli Slenders, Emmanuelle Morin, Natascha Arnauts, Michiel Op De Beeck, Annegret Kohler, Joske Ruytinx, Jan V Colpaert
Zinc (Zn) is an essential micronutrient but may become toxic when present in excess. In Zn-contaminated environments, trees can be protected from Zn toxicity by their root-associated micro-organisms, in particular ectomycorrhizal fungi. The mechanisms of cellular Zn homeostasis in ectomycorrhizal fungi and their contribution to the host tree's Zn status are however not yet fully understood. The aim of this study was to identify and characterize transporters involved in Zn uptake in the ectomycorrhizal fungus Suillus luteus, a cosmopolitan pine mycobiont...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29223976/zinc-detoxification-a-functional-genomics-and-transcriptomics-analysis-in-drosophila-melanogaster-cultured-cells
#14
Stephanie E Mohr, Kirstin Rudd, Yanhui Hu, Wei R Song, Quentin Gilly, Michael Buckner, Benjamin E Housden, Colleen Kelley, Jonathan Zirin, Rong Tao, Gabriel Amador, Katarzyna Sierzputowska, Aram Comjean, Norbert Perrimon
Cells require some metals, such as zinc and manganese, but excess levels of these metals can be toxic. As a result, cells have evolved complex mechanisms for maintaining metal homeostasis and surviving metal intoxication. Here, we present the results of a large-scale functional genomic screen in Drosophila cultured cells for modifiers of zinc chloride toxicity, together with transcriptomics data for wildtype or genetically zinc-sensitized cells challenged with mild zinc chloride supplementation. Altogether, we identified 47 genes for which knockdown conferred sensitivity or resistance to toxic zinc or manganese chloride treatment, and more than 1800 putative zinc-responsive genes...
December 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29218630/differential-reactivity-of-closely-related-zinc-ii-binding-metallothioneins-from-the-plant-arabidopsis-thaliana
#15
Hasan T Imam, Claudia A Blindauer
The dynamics of metal binding to and transfer from metalloproteins involved in metal homeostasis are important for understanding cellular distribution of metal ions. The dicotyledonous plant Arabidopsis thaliana has two type 4 seed-specific metallothionein homologues, MT4a and MT4b, with likely roles in zinc(II) homeostasis. These two metallothioneins are 84% identical, with full conservation of all metal-binding cysteine and histidine residues. Yet, differences in their spatial and temporal expression patterns suggested divergence in their biological roles...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218234/the-emerging-role-of-zinc-transporters-in-cellular-homeostasis-and-cancer
#16
Elizabeth Bafaro, Yuting Liu, Yan Xu, Robert E Dempski
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions to reduce cytoplasmic zinc concentrations and the ZIP (SLC39) family that functions to increase cytoplasmic zinc concentrations. Fluctuations in intracellular zinc levels mediated by these transporter families affect signaling pathways involved in normal cell development, growth, differentiation and death...
2017: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29217217/antioxidant-role-of-vitamin-d-in-mice-with-alloxan-induced-diabetes
#17
Sarah Iqbal, Saman Khan, Imrana Naseem
OBJECTIVES: The discovery of vitamin D receptors has revolutionized the understanding of vitamin D biology, which is now thought to influence a wide array of cell pathways. The antihyperglycemic actions of vitamin D involving calcium metabolism have been widely discussed, but studies are now suggesting a possibility of vitamin D-induced amelioration of oxidative stress. Despite its significance in disease pathogenesis, oxidative status remains poorly investigated with respect to vitamin D treatment in the biology of diabetes mellitus...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29212299/modulating-the-properties-of-metal-sensing-whole-cell-bioreporters-by-interfering-escherichia-coli-metal-homeostasis
#18
Youngdae Yoon, Yerin Kang, Woonwoo Lee, Sunghoon Kim, Ki-Cheol Oh, Bong-Gyu Kim
In Escherichia coli, the transcription of genes related to metal homeostasis is activated by the presence of target metals. The promoter regions of those genes can be fused with reporter genes to generate whole-cell bioreporters (WCBs); these organisms sense the presence of target metals through reporter gene expression. However, the limited number of available promoters for sensing domains restricts the number of WCB targets. In this study, we have demonstrated an alternative method to generate novel WCBs, based on the notion that since the sensing mechanisms of WCBs are related to metal transportation systems, their properties can be modulated by disrupting metal homeostasis...
December 8, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29203647/molecular-basis-for-the-integration-of-environmental-signals-by-furb-from-anabaena-sp-pcc-7120
#19
Violeta C Sein-Echaluce, María Carmen Pallarés, Anabael Lostao, Inmaculada Yruela, Adrián Velázquez-Campoy, M Luisa Peleato, María F Fillat
FUR proteins are among the most important families of transcriptional regulators in prokaryotes, often behaving as global regulators. In the cyanobacterium Anabaena PCC 7120 FurB (Zur) controls zinc and redox homeostasis through the repression of target genes in a zinc-dependent manner. In vitro , nonspecific binding of FurB to DNA elicits protection against oxidative damage and avoids cleavage by DNase I. This study provides for the first time evidence of the influence of redox environment in the interaction of FurB with regulatory zinc and its consequences in FurB-DNA binding affinity...
December 4, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29198169/stress-response-transcription-factors-msn2-and-msn4-couple-torc2-ypk1-signaling-and-mitochondrial-respiration-to-atg8-gene-expression-and-autophagy
#20
Ariadne Vlahakis, Nerea Lopez Muniozguren, Ted Powers
Macroautophagy/autophagy is a starvation and stress-induced catabolic process critical for cellular homeostasis and adaptation. Several Atg proteins are involved in the formation of the autophagosome and subsequent degradation of cytoplasmic components, a process termed autophagy flux. Additionally, the expression of several Atg proteins, in particular Atg8, is modulated transcriptionally, yet the regulatory mechanisms involved remain poorly understood. Here we demonstrate that the AGC kinase Ypk1, target of the rapamycin-insensitive TORC2 signaling pathway, controls ATG8 expression by repressing the heterodimeric Zinc-finger transcription factors Msn2 and Msn4...
December 4, 2017: Autophagy
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