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Zinc homeostasis

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https://www.readbyqxmd.com/read/28536273/metal-transporter-zip14-slc39a14-deletion-in-mice-increases-manganese-depositionnd-produces-neurotoxic-signaturesnd-diminished-motorctivity
#1
Tolunay Bekerydemir, Min-Hyun Kim, Jinhee Kim, Luis M Colon-Perez, Guita Banan, Thomas H Mareci, Marcelo Febo, Robert J Cousins
Mutations in human ZIP14 have been linked to symptoms of early onset of Parkinsonismnd Dystonia. This phenotype is likely related to excess manganeseccumulation in the central nervous system. The metal transporter ZIP14 (SLC39A14) is viewed primarilys zinc transporter that is inducible via proinflammatory stimuli. In vitro evidence shows that ZIP14 canlso transport manganese. To examine role for ZIP14 in manganese homeostasis, we used Zip14 knockout (KO) malend female mice to conduct comparative metabolic, imagingnd functional studies...
May 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28534099/effects-of-intermittent-and-continuous-magnetic-fields-on-trace-element-levels-in-guinea-pigs
#2
Onur Erdem, Cemal Akay, Sule Coşkun Cevher, Ayse Gulnihal Canseven, Ahmet Aydın, Nesrin Seyhan
Electromagnetic fields (EMFs) can affect living cells due to biochemical changes, followed by changes in levels of trace elements in serum and different organs. This study focuses on the effect of whole body exposure to EMF, presented everywhere in our environment, and on the levels of trace elements in serum, femur, brain, kidney, and liver tissues. The analyses performed on 29 guinea pigs were divided into five groups. Guinea pigs were exposed to a magnetic field of 50 Hz of 1.5 mT. Groups A and B were exposed to the magnetic field for a period of 4 h/day continuously (4 h/day) for 4 and 7 days, respectively...
May 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28528652/nutritional-immunity-and-fungal-pathogenesis-the-struggle-for-micronutrients-at-the-host-pathogen-interface
#3
Dhara Malavia, Aaron Crawford, Duncan Wilson
All living organisms require certain micronutrients such as iron, zinc, manganese and copper for cellular function and growth. For human pathogens however, the maintenance of metal ion homeostasis is particularly challenging. This is because the mammalian host actively enforces extremes of micronutrient availability on potential microbial invaders-processes collectively termed nutritional immunity. The role of iron sequestration in controlling microbial infections is well established and, more recently, the importance of other metals including zinc, manganese and copper has been recognised...
2017: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/28528650/the-role-of-intermetal-competition-and-mis-metalation-in-metal-toxicity
#4
Anna Barwinska-Sendra, Kevin J Waldron
The metals manganese, iron, cobalt, nickel, copper and zinc are essential for almost all bacteria, but their precise metal requirements vary by species, by ecological niche and by growth condition. Bacteria thus must acquire each of these essential elements in sufficient quantity to satisfy their cellular demand, but in excess these same elements are toxic. Metal toxicity has been exploited by humanity for centuries, and by the mammalian immune system for far longer, yet the mechanisms by which these elements cause toxicity to bacteria are not fully understood...
2017: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/28521682/repurposing-of-copper-ii-chelating-drugs-for-the-treatment-of-neurodegenerative-diseases
#5
Valeria Lanza, Danilo Milardi, Giuseppe Di Natale, Giuseppe Pappalardo
BACKGROUND: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews has exhaustively described either the molecular or clinical aspects of neurodegenerative diseases as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can be also effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) interacting molecules as potential drug candidates in neurodegeneration...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28516990/cross-talk-between-neurometals-and-amyloidogenic-proteins-at-the-synapse-and-the-pathogenesis-of-neurodegenerative-diseases
#6
REVIEW
M Kawahara, M Kato-Negishi, K Tanaka
Increasing evidence suggests that disruption of metal homeostasis contributes to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, prion diseases, Lewy body diseases, and vascular dementia. Conformational changes of disease-related proteins (amyloidogenic proteins), such as β-amyloid protein, prion proteins, and α-synuclein, are well-established contributors to neurotoxicity and to the pathogenesis of these diseases. Recent studies have demonstrated that these amyloidogenic proteins are metalloproteins that bind trace elements, including zinc, iron, copper, and manganese, and play significant roles in the maintenance of metal homeostasis...
May 18, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28516732/diadenosine-tetraphosphate-ap4a-an-e-coli-alarmone-or-a-damage-metabolite
#7
Dragana Despotović, Alexander Brandis, Alon Savidor, Yishai Levin, Laura Fumagalli, Dan S Tawfik
Under stress, metabolism is changing: specific up- or down-regulation of proteins and metabolites occurs as well as side-effects. Distinguishing specific stress-signaling metabolites (alarmones) from side-products (damage metabolites) is not trivial. One example is diadenosine tetraphosphate, Ap4A - a side-product of aminoacyl-tRNA synthetases found in all domains of life. The earliest observations suggested that Ap4A serves as an alarmone for heat stress in E. coli. However, despite 50 years of research, the signaling mechanisms associated with Ap4A remain unknown...
May 18, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28505300/impact-of-glutathione-metabolism-on-zinc-homeostasis-in-saccharomyces-cerevisiae
#8
Matthias G Steiger, Anett Patzschke, Caterina Holz, Christine Lang, Tim Causon, Stephan Hann, Diethard Mattanovich, Michael Sauer
Zinc is a crucial mineral for all organisms as it is an essential cofactor for the proper function of a plethora of proteins and depletion of zinc causes oxidative stress. Glutathione is the major redox buffering agent in the cell and therefore important for mitigation of the adverse effects of oxidative stress. In mammalian cells, zinc deficiency is accompanied by a glutathione depletion. In the yeast Saccharomyces cerevisiae, the opposite effect is observed: under low zinc conditions an elevated glutathione concentration is found...
May 12, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28503778/a-topical-zinc-ionophore-blocks-tumorigenic-progression-in-uv-exposed-skh-1-high-risk-mouse-skin
#9
Rebecca Justiniano, Jessica Perer, Anh Hua, Mohammad Fazel, Andrea Krajisnik, Christopher M Cabello, Georg T Wondrak
Nonmelanoma skin cancer (NMSC) is the most common malignancy in the United States representing a considerable public health burden. Pharmacological suppression of skin photo-carcinogenesis has shown promise in preclinical and clinical studies, but more efficacious photochemopreventive agents are needed. Here, we tested feasibility of harnessing pharmacological disruption of intracellular zinc-homeostasis for photochemoprevention in vitro and in vivo. Employing the zinc-ionophore and FDA-approved microbicidal agent zinc pyrithione (ZnPT), used worldwide in over-the-counter (OTC) topical consumer products, we first demonstrated feasibility of achieving ZnPT-based intracellular Zn(2+) -overload in cultured malignant keratinocytes (HaCaT-ras II-4; SCC-25) employing membrane-permeable fluorescent probes...
May 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28502593/meprin-metalloproteases-molecular-regulation-and-function-in-inflammation-and-fibrosis
#10
REVIEW
Philipp Arnold, Anna Otte, Christoph Becker-Pauly
The zinc-endopeptidases meprin α and meprin β are extracellular proteases involved in connective tissue homeostasis, intestinal barrier function and immunological processes. Meprins are unique amongst other extracellular proteases with regard to cleavage specificity and structure. Meprin α and meprin β have a strong preference for negatively charged amino acids around the scissile bond, reflected by cleavage sites identified in procollagen I, the amyloid precursor protein (APP) and the interleukin-6 receptor (IL-6R)...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28500379/effect-of-zinc-deprivation-on-the-lipid-metabolism-of-budding-yeast
#11
REVIEW
Neelima Singh, Kamlesh Kumar Yadav, Ram Rajasekharan
Zinc is an essential micronutrient for all living cells. It serves as a structural and catalytic cofactor for numerous proteins, hence maintaining a proper level of cellular zinc is essential for normal functioning of the cell. Zinc homeostasis is sustained through various ways under severe zinc-deficient conditions. Zinc-dependent proteins play an important role in biological systems and limitation of zinc causes a drastic change in their expression. In budding yeast, a zinc-responsive transcription factor Zap1p controls the expression of genes required for uptake and mobilization of zinc under zinc-limiting conditions...
May 12, 2017: Current Genetics
https://www.readbyqxmd.com/read/28496053/chemical-and-structural-biology-of-protein-lysine-deacetylases
#12
Minoru Yoshida, Norio Kudo, Saori Kosono, Akihiro Ito
Histone acetylation is a reversible posttranslational modification that plays a fundamental role in regulating eukaryotic gene expression and chromatin structure/function. Key enzymes for removing acetyl groups from histones are metal (zinc)-dependent and NAD(+)-dependent histone deacetylases (HDACs). The molecular function of HDACs have been extensively characterized by various approaches including chemical, molecular, and structural biology, which demonstrated that HDACs regulate cell proliferation, differentiation, and metabolic homeostasis, and that their alterations are deeply involved in various human disorders including cancer...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28492340/alterations-of-zinc-homeostasis-in-response-to-cryptococcus-neoformans-in-a-murine-macrophage-cell-line
#13
Francine Melise Dos Santos, Alícia Corbellini Piffer, Rafael de Oliveira Schneider, Nicole Sartori Ribeiro, Ane Wichine Acosta Garcia, Augusto Schrank, Lívia Kmetzsch, Marilene Henning Vainstein, Charley Christian Staats
AIM: To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile of macrophage zinc related homeostasis genes - metallothioneins and zinc transporters (ZnTs) of the SLC30 and SLC39 (Zrt-Irt-protein) families - was analyzed by quantitative PCR...
May 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28490676/excretion-of-zinc-and-copper-increases-in-men-during-3-weeks-of-bed-rest-with-or-without-artificial-gravity
#14
Hayley N Heacox, Patricia L Gillman, Sara R Zwart, Scott M Smith
Background: Zinc and copper have many physiologic functions and little or no functional storage capability, so persistent losses of either element present health concerns, especially during extended-duration space missions.Objectives: We evaluated the effects of short-term bed rest (BR), a spaceflight analog, on copper and zinc metabolism to better understand the role of these nutrients in human adaptation to (simulated) spaceflight. We also investigated the effect of artificial gravity on copper and zinc homeostasis...
May 10, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28488724/complex-effect-of-zinc-oxide-nanoparticles-on-cadmium-chloride-induced-hepatotoxicity-in-mice-protective-role-of-metallothionein
#15
Shang Gao, Xue Wang, Shasha Wang, Shanshan Zhu, Rui Rong, Xiaolong Xu
The wide range of applications of ZnO nanoparticles (nano ZnO) in commercial products and the ubiquitous cadmium (Cd) contamination in the natural environment increase the chance of co-existence of nano ZnO with Cd in the surroundings. To investigate the effects of nano ZnO on CdCl2-induced hepatotoxicity in mice, the histopathologic changes, metallothionein expression, oxidative stress responses and serum biochemical parameters were determined after oral administration of bulk or nano ZnO and/or CdCl2 for seven consecutive days...
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28483530/lamp-2-mediates-oxidative-stress-dependent-cell-death-in-zn-2-treated-lung-epithelium-cells
#16
Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Zhen Zou
Zinc is an essential element for the biological system. However, excessive exogenous Zn(2+) would disrupt cellular Zn(2+) homeostasis and cause toxicity. In particular, Zinc salts or ZnO nanoparticles exposure could induce respiratory injury. Although previous studies have indicated that organelle damage (including mitochondria or lysosomes) and reactive oxygen species (ROS) production are involved in Zn(2+)-induced toxicity, the interplay between mitochondria/lysosomes damage and ROS production is obscure...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28481273/agronomic-approach-of-zinc-biofortification-can-increase-zinc-bioavailability-in-wheat-flour-and-thereby-reduce-zinc-deficiency-in-humans
#17
Dunyi Liu, Yumin Liu, Wei Zhang, Xinping Chen, Chunqin Zou
Zinc (Zn) deficiency is a common disorder of humans in developing countries. The effect of Zn biofortification (via application of six rates of Zn fertilizer to soil) on Zn bioavailability in wheat grain and flour and its impacts on human health was evaluated. Zn bioavailability was estimated with a trivariate model that included Zn homeostasis in the human intestine. As the rate of Zn fertilization increased, the Zn concentration increased in all flour fractions, but the percentages of Zn in standard flour (25%) and bran (75%) relative to total grain Zn were constant...
May 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28481222/hepatic-metal-ion-transporter-zip8-regulates-manganese-homeostasis-and-manganese-dependent-enzyme-activity
#18
Wen Lin, David R Vann, Paschalis-Thomas Doulias, Tao Wang, Gavin Landesberg, Xueli Li, Emanuela Ricciotti, Rosario Scalia, Miao He, Nicholas J Hand, Daniel J Rader
Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with the regulation of whole-blood manganese (Mn) and multiple physiological traits. SLC39A8 encodes ZIP8, a divalent metal ion transporter best known for zinc transport. Here, we hypothesized that ZIP8 regulates Mn homeostasis and Mn-dependent enzymes to influence metabolism. We generated Slc39a8-inducible global-knockout (ZIP8-iKO) and liver-specific-knockout (ZIP8-LSKO) mice and observed markedly decreased Mn levels in multiple organs and whole blood of both mouse models...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28479083/zip9-a-novel-membrane-androgen-receptor-and-zinc-transporter-protein
#19
Peter Thomas, Aubrey Converse, Håkan A Berg
Rapid, androgen actions initiated at the cell surface have been reported in a variety of vertebrate cells, including several macrophage and prostate cancer cell lines that lack the nuclear androgen receptor. However, until recently the identity of the novel membrane androgen receptor (mAR) mediating these nonclassical androgen actions remained unknown. In 2014, a novel mAR unrelated to nuclear androgen receptors was identified in Atlantic croaker ovaries as the zinc transporter protein, ZIP9. ZIP9 is one of the 14 members of the ZIP (ZRT-and Irt-like Protein, SLC39A) family that regulates zinc homeostasis by transporting zinc across cell and organelle membranes into the cytoplasm...
May 4, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#20
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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