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https://www.readbyqxmd.com/read/28442659/diagnostic-accuracy-of-endocardial-to-epicardial-myocardial-blood-flow-ratio-for-the-detection-of-significant-coronary-artery-disease-with-dynamic-myocardial-perfusion-dual-source-computed-tomography
#1
Yoshitaka Goto, Kakuya Kitagawa, Mio Uno, Shiro Nakamori, Tatsuro Ito, Naoki Nagasawa, Kaoru Dohi, Hajime Sakuma
BACKGROUND: Previous dynamic stress computed tomography perfusion (CTP) studies used absolute myocardial blood flow (MBF in mL/100 g/min) as a threshold to discriminate flow-limiting coronary artery disease (CAD), but absolute MBF can be vary because of multiple factors. The aim of this study was to compare the diagnostic performance of absolute MBF and the transmural perfusion ratio (TPR) for the detection of flow-limiting CAD, and to clarify the influence of CT delayed enhancement (CTDE) on the diagnostic performance of CTP...
April 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28407326/maternal-lactocrine-programming-of-porcine-reproductive-tract-development
#2
REVIEW
Carol A Bagnell, Teh-Yuan Ho, Ashley F George, Anne A Wiley, Dori J Miller, Frank F Bartol
The lactocrine hypothesis for maternal programming of female reproductive tract development is based on the idea that non-nutritive, milk-borne bioactive factors (MbFs), delivered from mother to offspring during nursing, play a role in determining the trajectory of development with long-term consequences in the adult. Porcine female reproductive tract development is completed postnatally, and the period during which maternal support of neonatal growth derives exclusively from colostrum/milk defines a window of opportunity for lactocrine programming of reproductive tissues...
April 13, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28397180/measurement-of-mbf-by-pet-is-ready-for-prime-time-as-an-integral-part-of-clinical-reports-in-diagnosis-and-risk-assessment-of-patients-with-known-or-suspected-cad-for-prime-time-not-yet-need-impact-and-certainty
#3
Heinrich Schelbert
No abstract text is available yet for this article.
April 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28379843/direct-parametric-reconstruction-in-dynamic-pet-myocardial-perfusion-imaging-in-vivo-studies
#4
Yoann Petibon, Yothin Rakvongthai, Georges El Fakhri, Jinsong Ouyang
Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves-TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher SNR compared to the indirect method...
April 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28369259/diagnostic-value-of-global-myocardial-perfusion-reserve-assessment-based-on-coronary-sinus-flow-measurements-using-cardiovascular-magnetic-resonance-in-addition-to-myocardial-stress-perfusion-imaging
#5
Zornitsa Shomanova, Anca Florian, Michael Bietenbeck, Johannes Waltenberger, Udo Sechtem, Ali Yilmaz
Aims: Myocardial perfusion reserve (MPR) is defined as the maximal possible increase in myocardial blood flow (MBF) above baseline conditions. Global MBF can be measured non-invasively by means of coronary sinus flow velocity encoded cine (VENC) cardiovascular magnetic resonance (CMR). We aimed to explore the relationship between global MBF/MPR and the extent and severity of coronary artery disease (CAD) in patients referred for CAD work-up by adenosine-stress CMR. Methods and results: Fifty-eight patients with suspected obstructive CAD underwent both adenosine-stress CMR and invasive coronary angiography...
March 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28365789/single-scan-rest-stress-imaging-validation-in-a-porcine-model-with-18-f-flurpiridaz
#6
Nicolas J Guehl, Marc D Normandin, Dustin W Wooten, Guy Rozen, Arkadiusk Sitek, Jeremy Ruskin, Timothy M Shoup, Leon M Ptaszek, Georges El Fakhri, Nathaniel M Alpert
PURPOSE: (18)F-labeled myocardial flow agents are becoming available for clinical application but the ∼2 hour half-life of (18)F complicates their clinical application for rest-stress measurements. The goal of this work is to evaluate in a pig model a single-scan method which provides quantitative rest-stress blood flow in less than 15 minutes. METHODS: Single-scan rest-stress measurements were made using (18)F-Flurpiridaz. Nine scans were performed in healthy pigs and seven scans were performed in injured pigs...
April 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28359663/higher-maximal-occlusal-bite-force-in-endodontically-treated-teeth-versus-vital-contralateral-counterparts
#7
Lama Awawdeh, Khalid Hemaidat, Wael Al-Omari
INTRODUCTION: Decreased sensitivity to occlusal load could lead to a greater risk of damage to endodontically treated teeth. Therefore, this study aims to test whether root canal treatment reduces the sensitivity of the treated teeth to occlusal load. METHODS: This is a comparative cross-sectional study of 124 patients who received root canal treatment. Treated teeth were compared with vital teeth on the contralateral side. After interviews with participants, their maximal bite forces (MBFs) of their root canal-treated and contralateral untreated teeth were measured using a digital bite fork force transducer...
March 28, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28331178/habitat-filtering-and-exclusion-of-weak-competitors-jointly-explain-fern-species-assemblage-along-a-light-and-water-gradient
#8
Hui Zhang, Shidan Zhu, Robert John, Ronghua Li, Hui Liu, Qing Ye
Fern species are an important component of the diversity of forest plant communities, but very little is known about how fern communities assemble in different environments. In this study, we use multiple trait-based tests to examine the relationships between several key eco-physiological traits which are direct indicators of shade and drought tolerance, and the abundance of fern species in pine forest (PF), pine and mixed broad leaf forest (PMBF) and matured broad leaf forest (MBF) in southern China. These forests are characterized by decreasing light but increasing water availability during succession, and the fern communities correspondingly differ in species composition...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299034/the-effect-of-a-lifestyle-modification-education-on-adiposity-measures-in-overweight-and-obese-nonalcoholic-fatty-liver-disease-patients
#9
Arman Arab, Gholamreza Askari, Parastoo Golshiri, Awat Feizi, Ali Hekmatnia, Bijan Iraj, Mojgan Nourian
BACKGROUND: Obesity is increasingly associated with nonalcoholic fatty liver disease (NAFLD) and weight loss through a combination of dietary modifications and increased physical activity is a primary goal of therapy in this disease. Therefore, this study was conducted to evaluate the effects of a lifestyle modification education on adiposity measures, physical activity, and total calorie intake in overweight and obese NAFLD patients. METHODS: During 8 weeks, 82 obese patients were randomly assigned into either an intervention group (n = 41) receiving a lifestyle modification education or to a control group (n = 41) receiving usual care...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28293274/optimally-repeatable-kinetic-model-variant-for-myocardial-blood-flow-measurements-with-82-rb-pet
#10
Adrian F Ocneanu, Robert A deKemp, Jennifer M Renaud, Andy Adler, Rob S B Beanlands, Ran Klein
Purpose. Myocardial blood flow (MBF) quantification with (82)Rb positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic (82)Rb PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV)...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28292884/vascular-conductance-and-muscle-blood-flow-during-exercise-are-altered-by-inspired-oxygen-fraction-and-arterial-perfusion-pressure
#11
Rodrigo Villar, Richard L Hughson
We tested the hypothesis during the combined challenges of altered inspired O2 fraction (FIO2) and posture changes at lower power output regardless of body position that the vascular conductance (VC) recruitment to the exercising muscle would not limit muscle perfusion and estimated O2 delivery (DO2est ). However, in head-down tilt at the higher power output exercise in hypoxia, the recruitment of VC would have a functional limitation which would restrict muscle blood flow (MBF) leading to a limitation in DO2est with consequent increases in metabolic stress...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28273102/age-related-differences-in-skeletal-muscle-microvascular-response-to-exercise-as-detected-by-contrast-enhanced-ultrasound-ceus
#12
Wulf Hildebrandt, Hans Schwarzbach, Anita Pardun, Lena Hannemann, Björn Bogs, Alexander M König, Andreas H Mahnken, Olaf Hildebrandt, Ulrich Koehler, Ralf Kinscherf
BACKGROUND: Aging involves reductions in exercise total limb blood flow and exercise capacity. We hypothesized that this may involve early age-related impairments of skeletal muscle microvascular responsiveness as previously reported for insulin but not for exercise stimuli in humans. METHODS: Using an isometric exercise model, we studied the effect of age on contrast-enhanced ultrasound (CEUS) parameters, i.e. microvascular blood volume (MBV), flow velocity (MFV) and blood flow (MBF) calculated from replenishment of Sonovue contrast-agent microbubbles after their destruction...
2017: PloS One
https://www.readbyqxmd.com/read/28270281/application-of-the-low-dose-one-stop-shop-cardiac-ct-protocol-with-third-generation-dual-source-ct
#13
Lu Lin, Yining Wang, Yan Yi, Jian Cao, Lingyan Kong, Hao Qian, Hongzhi Zhang, Wei Wu, Yun Wang, Zhengyu Jin
Objective To evaluate the feasibility of a low-dose one-stop-shop cardiac CT imaging protocol with third-generation dual-source CT (DSCT). Methods Totally 23 coronary artery disease (CAD) patients were prospectively enrolled between March to September in 2016. All patients underwent an ATP stress dynamic myocardial perfusion imaging (MPI) (data acquired prospectively ECG-triggered during end systole by table shuttle mode in 32 seconds) at 70 kV combined with prospectively ECG-triggered high-pitch coronary artery angiography (CCTA) on a third-generation DSCT system...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28254864/arterial-co2-as-a-potent-coronary-vasodilator-a-preclinical-pet-mr-validation-study-with-implications-for-cardiac-stress-testing
#14
Hsin-Jung Yang, Damini Dey, Jane Sykes, Michael Klein, John Butler, Michael Kovacs, Olivia Sobczyk, Behzad Sharif, Xiaoming Bi, Avinash Kali, Ivan Cokic, Richard Tang, Roya Yumul, Antonio Conte, Sotirios Tsaftaris, Mourad Tighiouart, Debiao Li, Piotr J Slomka, Daniel Berman, Frank Prato, Joseph Fisher, Rohan Dharmakumar
Myocardial blood flow (MBF) is the critical determinant of cardiac function. However, its response to increases in partial pressure of arterial CO2 (PaCO2), particularly with respect to adenosine, is not well characterized due to challenges in blood gas control and limited availability of validated approaches to ascertain MBF in vivo. By prospectively and independently controlling PaCO2 and combining it with (13)N-ammonia Positron Emission Tomography (PET) measurements, we investigated whether a physiologically tolerable hypercapnic stimulus (~25-mmHg increase in PaCO2) can increase MBF to that observed with adenosine in three groups of canines: (i) without coronary stenosis; (ii) subjected to non-flow limiting coronary stenosis; and (iii) following pre-administration of caffeine...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28252111/bioresources-inner-recycling-between-bioflocculation-of-microcystis-aeruginosa-and-its-reutilization-as-a-substrate-for-bioflocculant-production
#15
Liang Xu, Mingxin Huo, Caiyun Sun, Xiaochun Cui, Dandan Zhou, John C Crittenden, Wu Yang
Bioflocculation, being environmental-friendly and highly efficient, is considered to be a promising method to harvest microalgae. However, one limitation of this technology is high expense on substrates for bioflocculant bacteria cultivation. In this regard, we developed an innovative method for the inner-recycling of biomass that could harvest the typical microalgae, Microcystis aeruginosa, using a bioflocculant produced by Citrobacter sp. AzoR-1. In turn, the flocculated algal biomass could be reutilized as a substrate for Citrobacter sp...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28244122/influence-of-sustained-submaximal-clenching-fatigue-test-on-electromyographic-activity-and-maximum-voluntary-bite-forces-in-healthy-subjects-and-patients-with-temporomandibular-disorders
#16
L Xu, S Fan, B Cai, Z Fang, X Jiang
This study aimed to investigate whether the fatigue induced by sustained motor task in the jaw elevator muscles differed between healthy subjects and patients with temporomandibular disorder (TMD). Fifteen patients with TMD and thirteen age- and sex-matched healthy controls performed a fatigue test consisting of sustained clenching contractions at 30% maximal voluntary clenching intensity until test failure (the criterion for terminating the fatigue test was when the biting force decreased by 10% or more from the target force consecutively for >3 s)...
February 28, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28242588/effects-of-successful-percutaneous-coronary-intervention-of-chronic-total-occlusions-on-myocardial-perfusion-and-left-ventricular-function
#17
Wijnand J Stuijfzand, P Stefan Biesbroek, Pieter G Raijmakers, Roel S Driessen, Stefan P Schumacher, Pepijn van Diemen, Jeffrey van den Berg, Robin Nijveldt, Adriaan A Lammertsma, Simon J Walsh, Colm G Hanratty, James C Spratt, Albert C van Rossum, Alexander Nap, Niels van Royen, Paul Knaapen
AIMS: The aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery. METHODS AND RESULTS: Patients with a documented CTO were prospectively examined for ischemia and viability with H215O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function...
February 28, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28228404/endothelial-colony-forming-cells-ameliorate-endothelial-dysfunction-via-secreted-factors-following-ischemia-reperfusion-injury
#18
Jason A Collett, Purvi Mehrotra, Allison Crone, W Christopher Shelley, Mervin C Yoder, David P Basile
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and in vivo vessel forming potential. We hypothesized that ECFCs may ameliorate the degree of AKI and/or promote repair of the renal vasculature following ischemia/reperfusion (I/R). Rat pulmonary microvascular ECs (PMVEC) with high proliferative potential were compared with pulmonary artery ECs (PAEC) with low proliferative potential in rats subjected to renal I/R...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28205113/cardiac-pet-ct-with-rb-82-optimization-of-image-acquisition-and-reconstruction-parameters
#19
P Chilra, S Gnesin, G Allenbach, M Monteiro, J O Prior, L Vieira, J A Pires Jorge
BACKGROUND: Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in (82)Rb PET/CT quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Rest and stress list-mode dynamic (82)Rb PET acquisition data from 10 patients without myocardial flow defects and 10 patients with myocardial blood flow defects were reconstructed retrospectively...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28202246/analysis-of-myocardial-perfusion-parameters-in-an-ex-vivo-porcine-heart-model-using-third-generation-dual-source-ct
#20
Gert Jan Pelgrim, Taylor M Duguay, J Marco A Stijnen, Akos Varga-Szemes, Sjoerd Van Tuijl, U Joseph Schoepf, Matthijs Oudkerk, Rozemarijn Vliegenthart
PURPOSE: To evaluate the relationship between fractional flow reserve (FFR)-determined coronary artery stenosis severity and myocardial perfusion parameters derived from dynamic myocardial CT perfusion imaging (CTP) in an ex-vivo porcine heart model. METHODS: Six porcine hearts were perfused according to Langendorff. Circulatory parameters such as arterial blood flow (ABF) (L/min), mean arterial pressure (MAP) (mmHg) and heart rate (bpm) were monitored. Using an inflatable cuff and monitored via a pressure wire, coronary artery stenoses of different FFR grades were created (no stenosis, FFR = 0...
February 3, 2017: Journal of Cardiovascular Computed Tomography
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