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https://www.readbyqxmd.com/read/29678336/stress-myocardial-blood-flow-heterogeneity-is-a-positron-emission-tomography-biomarker-of-ventricular-arrhythmias-in-patients-with-hypertrophic-cardiomyopathy
#1
Dai-Yin Lu, Hulya Yalçin, Fatih Yalçin, Min Zhao, Sanjay Sivalokanathan, Ines Valenta, Abdel Tahari, Martin G Pomper, Theodore P Abraham, Thomas H Schindler, M Roselle Abraham
Patients with hypertrophic cardiomyopathy (HC) are at increased risk of sudden cardiac death. Abnormalities in myocardial blood flow (MBF) detected by positron emission tomography (PET) are common in HC, but a PET marker that identifies patients at risk of sudden cardiac death is lacking. We hypothesized that disparities in regional myocardial perfusion detected by PET would identify patients with HC at risk of ventricular arrhythmias. To test this hypothesis, we quantified global and regional MBFs by 13 NH3 -PET at rest and at stress, and developed a heterogeneity index to assess MBF heterogeneity in 133 symptomatic patients with HC...
February 6, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29674972/gualou-xiebai-decoction-a-traditional-chinese-medicine-prevents-cardiac-reperfusion-injury-of-hyperlipidemia-rat-via-energy-modulation
#2
Lu-Lu Yan, Wei-Yang Zhang, Xiao-Hong Wei, Li Yan, Chun-Shui Pan, Yang Yu, Jing-Yu Fan, Yu-Ying Liu, Hua Zhou, Jing-Yan Han, Xin-Sheng Yao
Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK pathway. Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29660905/differences-in-time-domain-and-spectral-indexes-of-skin-surface-laser-doppler-signals-between-controls-and-breast-cancer-subjects
#3
Hsin Hsiu, Chao-Tsung Chen, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang
BACKGROUND: There is an urgent need to improve the early diagnosis of breast cancer. OBJECTIVE: The present study applied spectral and beat-to-beat analyses to laser-Doppler (LDF) data sequences measured on the skin surface on the back of the right hands, with the aim of comparing the different peripheral microcirculatory-blood-flow (MBF) perfusion condition between breast-cancer and control subjects. METHODS: ECG and LDF signals were obtained simultaneously and noninvasively from 23 breast-cancer patients and 23 age-matched control subjects...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29643278/absolute-myocardial-blood-flow-after-elective-percutaneous-coronary-intervention-evaluated-on-phase-contrast-cine-cardiovascular-magnetic-resonance-imaging
#4
Rikuta Hamaya, Akinori Sugano, Yoshihisa Kanaji, Tadashi Fukuda, Yoshinori Kanno, Taishi Yonetsu, Eisuke Usui, Masahiro Hoshino, Masahiro Hada, Hiroaki Ohya, Yohei Sumino, Haruhito Yuki, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: Few studies have documented changes in myocardial blood flow (MBF) after percutaneous coronary intervention (PCI). Phase-contrast cine cardiovascular MRI (PC-CCMR) of the coronary sinus (CS) is a promising approach to quantify MBF. The aim of this study was to quantify CS flow (CSF) on PC-CCMR as a measure of volumetric MBF before and after elective PCI.Methods and Results:We prospectively studied 34 patients with stable angina undergoing elective PCI for a single de novo lesion...
April 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29627375/longer-diabetes-duration-reduces-myocardial-blood-flow-in-remote-myocardium-assessed-by-dynamic-myocardial-ct-perfusion
#5
Nobuo Tomizawa, Yusuke Fujino, Masaru Kamitani, Shengpu Chou, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
AIMS: To investigate the relationship of type 2 diabetes duration and myocardial blood flow (MBF) assessed by myocardial CT perfusion. MATERIALS AND METHODS: We prospectively included 140 patients with type 2 diabetes who underwent dynamic myocardial CT perfusion exam. MBF of the remote myocardium was calculated using the deconvolution technique and the Voronoi method. The relationships of MBF and diabetic duration, diabetic complications, conventional risk factors, coronary calcium, and coronary stenosis were assessed by logistic regression analysis...
March 16, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29610620/evaluation-of-maximum-bite-force-in-patients-with-complete-dentures
#6
Kujtim Shala, Arlinda Tmava-Dragusha, Linda Dula, Teuta Pustina-Krasniqi, Teuta Bicaj, Enis Ahmedi, Zana Lila
OBJECTIVE: This study aimed to evaluate maximum bite forces (mBF) in dominant (DS) and non-dominant sides (NDS) at certain time periods after the insertion of new complete dentures based on prior experience and gender. MATERIALS AND METHODS: A total of 88 patients, complete denture wearers (CDWs), were examined. The maximum bite force at the intercuspal position between the first molars in 3 seconds was registered and recorded with piezoelectric gnathodynamometer...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29606367/t-max-is-a-sensitive-indicator-of-myocardial-ischaemia-under-adenosine-stress-as-determined-by-static-pet-imaging-a-study-in-a-porcine-model
#7
S Sui, Y Hou, Y Ma, Y Wang, M Yu, Y Yang, N Huang
AIM: To evaluate Tmax , defined as the time of residual function R(t) reaching its maximum, as an indicator of myocardial ischaemia and compare its efficacy with other computed tomography perfusion (CTP) parameters. MATERIALS AND METHODS: Eight Bama miniature pigs with 50-90% left anterior descending artery stenosis underwent adenosine stress myocardial CTP and13 NNH3 position-emission tomography (PET) perfusion imaging. Tmax , myocardial blood flow (MBF), myocardial blood volume (MBV), mean transit time (MTT), and time to peak (TTP) were calculated from CTP images...
March 29, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29598865/pet-assessment-of-epicardial-intimal-disease-and-microvascular-dysfunction-in-cardiac-allograft-vasculopathy
#8
Sharon Chih, Aun Yeong Chong, Fernanda Erthal, Robert A deKemp, Ross A Davies, Ellamae Stadnick, Derek Y So, Christopher Overgaard, George Wells, Lisa M Mielniczuk, Rob S B Beanlands
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure and death after heart transplantation. Absolute myocardial blood flow (MBF) quantification using rubidium 82 (Rb-82) positron emission tomography (PET) could enable evaluation of diagnostically challenging diffuse epicardial and microvascular disease in CAV. OBJECTIVES: The authors aimed to evaluate Rb-82 PET detection of CAV. METHODS: Consecutive transplant recipients undergoing coronary angiography were prospectively evaluated with PET, multivessel intravascular ultrasound (IVUS), and intracoronary hemodynamics...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29574494/motion-correction-and-its-impact-on-absolute-myocardial-blood-flow-measures-with-pet
#9
REVIEW
Marina Piccinelli, John R Votaw, Ernest V Garcia
PURPOSE OF REVIEW: Motion artifacts, due to cardiac and respiratory cycles, myocardial cardiac creep, or gross patient movements, have been extensively investigated in the context of relative myocardial perfusion imaging with SPECT and PET. These movements have been identified as a major source of errors in image quantification and diagnosis. Recently, as dynamic PET quantification for myocardial blood flow assessment has entered clinical practice, similar questions have arisen on the impact of motion on final blood flow values...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29572594/blood-pool-and-tissue-phase-patient-motion-effects-on-82-rubidium-pet-myocardial-blood-flow-quantification
#10
Benjamin C Lee, Jonathan B Moody, Alexis Poitrasson-Rivière, Amanda C Melvin, Richard L Weinberg, James R Corbett, Edward P Ficaro, Venkatesh L Murthy
BACKGROUND: Patient motion can lead to misalignment of left ventricular volumes of interest and subsequently inaccurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from dynamic PET myocardial perfusion images. We aimed to identify the prevalence of patient motion in both blood and tissue phases and analyze the effects of this motion on MBF and MFR estimates. METHODS: We selected 225 consecutive patients that underwent dynamic stress/rest rubidium-82 chloride (82 Rb) PET imaging...
March 23, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29568814/glp-1-and-insulin-recruit-muscle-microvasculature-and-dilate-conduit-artery-individually-but-not-additively-in-healthy-humans
#11
Alvin W K Tan, Sharmila C Subaran, Matthew A Sauder, Weidong Chai, Linda A Jahn, Dale E Fowler, James T Patrie, Kevin W Aylor, Ananda Basu, Zhenqi Liu
Context: Glucagon-like peptide-1 (GLP-1) and insulin increase muscle microvascular perfusion, thereby increasing tissue endothelial surface area and nutrient delivery. Objective: To examine whether GLP-1 and insulin act additively on skeletal and cardiac microvasculature and conduit artery. Design: Healthy adults underwent three study protocols in random order. Setting: Clinical Research Unit at the University of Virginia...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29556942/feasibility-of-myocardial-flow-reserve-prediction-without-the-use-of-dynamic-data-from-myocardial-perfusion-positron-emission-tomography
#12
Hidenobu Hashimoto, Yoshimitsu Fukushima, Shin-Ichiro Kumita, Takeshi Tomiyama, Tomonari Kiriyama
Quantification of myocardial flow reserve (MFR) provides diagnostic value for detection of cardiovascular artery disease. However, the common calculation method for MFR requires dynamic acquisition and specific software. The study aimed to predict coronary artery disease by simpler calculation of myocardial count without the use of dynamic data from13 N-ammonia myocardial perfusion positron emission tomography (MP-PET). This study included 40 consecutive patients suspected of ischemic heart disease and 7 healthy controls (34 men and 13 women, 66 ± 12 years)...
March 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29530846/micafungin-breakthrough-fungemia-in-patients-with-hematological-disorders
#13
Muneyoshi Kimura, Hideki Araoka, Hisashi Yamamoto, Shigeki Nakamura, Minoru Nagi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Sho Ogura, Takashi Mitsuki, Mitsuhiro Yuasa, Daisuke Kaji, Kosei Kageyama, Aya Nishida, Yuki Taya, Hiroshi Shimazu, Kazuya Ishiwata, Shinsuke Takagi, Go Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Akiko Yoneyama
Limited data are available on micafungin breakthrough fungemia (MBF), fungemia that develops on administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records of patients with hematological disorders who developed MBF between January 2008 and June 2015. A total of 39 patients with MBF were identified and Candida (30 strains) and non- Candida (9 strains) fungal species were recognized as causative strains. Among 35 stored strains, C. parapsilosis (14 strains), Trichosporon asahii (7 strains), C...
March 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29515645/evaluation-of-capillary-leakage-after-vasopressin-resuscitation-in-a-hemorrhagic-shock-model
#14
Roberto Bini, Osvaldo Chiara, Stefania Cimbanassi, Giorgio Olivero, Antonella Trombetta, Paolo Cotogni
Background: Hemorrhagic shock (HS) is a major threat to patients with trauma and spontaneous bleeding. The aim of the study was to investigate early effects of vasopressin on metabolic and hemodynamic parameters and endothelium permeability by measuring capillary leakage compared to those of other resuscitation strategies in a HS model. Methods: Forty-five Sprague-Dawley rats were randomized into five groups: S group ( n  = 5), sham-operated rats without shock or resuscitation; HS group ( n  = 10), HS and no resuscitation; RL group ( n  = 10), HS and resuscitation with Ringer's lactate (RL); RLB group ( n  = 10), HS and resuscitation with two-third shed blood plus RL; and vasopressin group ( n  = 10), HS and resuscitation with RL, followed by continuous infusion of 0...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29514708/fully-quantitative-pixel-wise-analysis-of-cardiovascular-magnetic-resonance-perfusion-improves-discrimination-of-dark-rim-artifact-from-perfusion-defects-associated-with-epicardial-coronary-stenosis
#15
Allison D Ta, Li-Yueh Hsu, Hannah M Conn, Susanne Winkler, Anders M Greve, Sujata M Shanbhag, Marcus Y Chen, W Patricia Bandettini, Andrew E Arai
BACKGROUND: Dark rim artifacts in first-pass cardiovascular magnetic resonance (CMR) perfusion images can mimic perfusion defects and affect diagnostic accuracy for coronary artery disease (CAD). We evaluated whether quantitative myocardial blood flow (MBF) can differentiate dark rim artifacts from true perfusion defects in CMR perfusion. METHODS: Regadenoson perfusion CMR was performed at 1.5 T in 76 patients. Significant CAD was defined by quantitative invasive coronary angiography (QCA) ≥ 50% diameter stenosis...
March 8, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29497801/first-validation-of-myocardial-flow-reserve-assessed-by-dynamic-99m-tc-sestamibi-czt-spect-camera-head-to-head-comparison-with-15-o-water-pet-and-fractional-flow-reserve-in-patients-with-suspected-coronary-artery-disease-the-waterday-study
#16
Denis Agostini, Vincent Roule, Catherine Nganoa, Nathaniel Roth, Raphael Baavour, Jean-Jacques Parienti, Farzin Beygui, Alain Manrique
PURPOSE: We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with15 O-water PET and fractional flow reserve (FFR). METHODS: Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress99m Tc-sestamibi CZT-SPECT and15 O-water PET for MBF and MFR calculation...
March 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29495996/diagnosis-of-microvascular-angina-using-cardiac-magnetic-resonance
#17
Alexander Liu, Rohan S Wijesurendra, Joanna M Liu, John C Forfar, Keith M Channon, Michael Jerosch-Herold, Stefan K Piechnik, Stefan Neubauer, Rajesh K Kharbanda, Vanessa M Ferreira
BACKGROUND: In patients with angina and nonobstructive coronary artery disease (NOCAD), confirming symptoms due to coronary microvascular dysfunction (CMD) remains challenging. Cardiac magnetic resonance (CMR) assesses myocardial perfusion with high spatial resolution and is widely used for diagnosing obstructive coronary artery disease (CAD). OBJECTIVES: The goal of this study was to validate CMR for diagnosing microvascular angina in patients with NOCAD, compared with patients with obstructive CAD and correlated to the index of microcirculatory resistance (IMR) during invasive coronary angiography...
March 6, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29481443/micronutrient-status-and-nutritional-intake-in-0-2-year-old-children-consuming-a-cows-milk-exclusion-diet
#18
Janne Anita Kvammen, Rut Anne Thomassen, Mari Borge Eskerud, Jarle Rugtveit, Christine Henriksen
OBJECTIVES AND STUDY: To study micronutrient status and nutritional intake from complementary feeding in children on a cows' milk exclusion (CME) diet. METHODS: Fifty-seven children with cows' milk allergy, aged < 2 years, were included in a cross-sectional study. Blood was analysed for micronutrient status. Complementary feeding was defined as all solids and liquids except of breastmilk, and assessed by 3-day food diary. The results were analysed according to three feeding patterns: mainly breastfed (mBF), partially breastfed (pBF) and no breastmilk group (nBM)...
February 23, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470136/-15-o-h-2-o-pet-ct-as-a-tool-for-the-quantitative-assessement-of-early-post-radiotherapy-changes-of-heart-perfusion-in-breast-carcinoma-patients
#19
Agnieszka Żyromska, Bogdan Małkowski, Tomasz Wiśniewski, Karolina Majewska, Joanna Reszke, Roman Makarewicz
OBJECTIVE: Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker of heart damage in irradiated breast cancer patients. METHODS: Fifteen breast cancer patients receiving intact breast or chest wall irradiation were included in the analysis (six with right-sided and nine with left-sided breast cancer)...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29467677/ginsenoside-rg1-ameliorates-rat-myocardial-ischemia-reperfusion-injury-by-modulating-energy-metabolism-pathways
#20
Lin Li, Chun-Shui Pan, Li Yan, Yuan-Chen Cui, Yu-Ying Liu, Hong-Na Mu, Ke He, Bai-He Hu, Xin Chang, Kai Sun, Jing-Yu Fan, Li Huang, Jing-Yan Han
As a major ingredient of Radix ginseng , ginsenoside Rg1 (Rg1) has been increasingly recognized to benefit the heart condition, however, the rationale behind the role is not fully understood. In vitro study in H9c2 cardiomyocytes has shown the potential of Rg1 to increase ATP content in the cells. We thus speculated that the protective effect of Rg1 on heart ischemia and reperfusion (I/R) injury implicates energy metabolism regulation. The present study was designed to verify this speculation. Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min...
2018: Frontiers in Physiology
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