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https://www.readbyqxmd.com/read/28817662/single-scan-rest-stress-imaging-with-99mtc-sestamibi-and-cadmium-zinc-telluride-based-spect-for-hyperemic-flow-quantification-a-feasibility-study-evaluated-with-cardiac-magnetic-resonance-imaging
#1
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
https://www.readbyqxmd.com/read/28808841/prognostic-significance-of-myocardial-energy-expenditure-and-myocardial-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#2
Mehmet S Cetin, Elif H Ozcan Cetin, Ugur Canpolat, Hatice Sasmaz, Ahmet Temizhan, Sinan Aydogdu
In heart failure with reduced ejection fraction (HFrEF) patients, myocardial blood flow (MBF), myocardial energy expenditure (MEE), myocardial efficiency has been poorly evaluated because of the necessity of invasive procedures in the determination of these parameters. Transthoracic echocardiography (TTE) can provide reliable data for MEE, MBF (via coronary sinus (CS) flows). Also, myocardial efficiency can be evaluated by the MEE to MBF ratio. We aim to assess MBF, MEE and energy efficiency and the prognostic value of these parameters in HFrEF...
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#3
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28771906/cdk1-interacting-protein-cip1-is-regulated-by-the-s%C3%A2-phase-checkpoint-in-response-to-genotoxic-stress
#4
Ze Zhang, Ping Ren, Ajay A Vashisht, James A Wohlschlegel, David G Quintana, Fanli Zeng
In eukaryotic cells, a surveillance mechanism, the S phase checkpoint, detects and responds to insults that challenge chromosomal replication, arresting cell cycle progression and triggering appropriate events to prevent genomic instability. In the budding yeast Saccharomyces cerevisiae, Mec1/ATM/ATR, and its downstream kinase, Rad53/Chk2, mediate the response to genotoxic stress. In this study, we place Cip1, a recently identified Cdk1 inhibitor (CKI), under the regulation of Mec1 and Rad53 in response to genotoxic stress...
August 3, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28770459/effect-of-liraglutide-on-myocardial-glucose-uptake-and-blood-flow-in-stable-chronic-heart-failure-patients-a-double-blind-randomized-placebo-controlled-live-sub-study
#5
Roni Nielsen, Anders Jorsal, Peter Iversen, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jens Sørensen, Hendrik Johannes Harms, Allan Flyvbjerg, Lise Tarnow, Caroline Kistorp, Ida Gustafsson, Hans Erik Bøtker, Henrik Wiggers
BACKGROUND: The glucagon-like peptide-1 analog liraglutide increases heart rate and may be associated with more cardiac events in chronic heart failure (CHF) patients. We studied whether this could be ascribed to effects on myocardial glucose uptake (MGU), myocardial blood flow (MBF) and MBF reserve (MFR). METHODS AND RESULTS: CHF patients with left ventricular ejection fraction ≤45% and without type 2 diabetes were randomized to liraglutide (N = 18) 1.8 mg once daily or placebo (N = 18) for 24 weeks in a double-blinded design...
August 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28770213/positron-emission-tomography-determined-hyperemic-flow-myocardial-flow-reserve-and-flow-gradient-quo-vadis
#6
REVIEW
Thorsten M Leucker, Ines Valenta, Thomas Hellmut Schindler
Positron emission tomography/computed tomography (PET/CT) applied with positron-emitting flow tracers such as (13)N-ammonia and (82)Rubidium enables the quantification of both myocardial perfusion and myocardial blood flow (MBF) in milliliters per gram per minute for coronary artery disease (CAD) detection and characterization. The detection of a regional myocardial perfusion defect during vasomotor stress commonly identifies the culprit lesion or most severe epicardial narrowing, whereas adding regional hyperemic MBFs, myocardial flow reserve (MFR), and/or longitudinal flow decrease may also signify less severe but flow-limiting stenosis in multivessel CAD...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28751169/differences-in-laser-doppler-indices-between-skin-surface-measurement-sites-in-subjects-with-diabetes
#7
Hsin Hsiu, Hsiao-Feng Hu, Hung-Chi Tsai
This study performed laser-Doppler flowmetry (LDF) measurements with the aim of identifying differences in diabetes-induced microcirculatory-blood-flow (MBF) responses between the following skin surface measurement sites: an acupoint around the wrist, an acupoint around the ankle, and a nearby nonacupoint around the ankle. The 67 study subjects were assigned to diabetic, prediabetic, and healthy groups according to the results of oral glucose tolerance tests. Beat-to-beat and spectral analyses were applied to the LDF waveform to obtain the foot delay time (FDT), the flow rise time (FRT), and the relative energy contributions (RECs) in five frequency bands...
July 25, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28744706/the-evolution-of-a-g1-s-transcriptional-network-in-yeasts
#8
REVIEW
Adi Hendler, Edgar M Medina, Nicolas E Buchler, Robertus A M de Bruin, Amir Aharoni
The G1-to-S cell cycle transition is promoted by the periodic expression of a large set of genes. In Saccharomyces cerevisiae G1/S gene expression is regulated by two transcription factor (TF) complexes, the MBF and SBF, which bind to specific DNA sequences, the MCB and SCB, respectively. Despite extensive research little is known regarding the evolution of the G1/S transcription regulation including the co-evolution of the DNA binding domains with their respective DNA binding sequences. We have recently examined the co-evolution of the G1/S TF specificity through the systematic generation and examination of chimeric Mbp1/Swi4 TFs containing different orthologue DNA binding domains in S...
July 25, 2017: Current Genetics
https://www.readbyqxmd.com/read/28722830/ralfuranones-contribute-to-mushroom-type-biofilm-formation-by-ralstonia-solanacearum-strain-oe1-1
#9
Yuka Mori, Yuki Hosoi, Shiho Ishikawa, Kazusa Hayashi, Yu Asai, Hideyuki Ohnishi, Mika Shimatani, Kanako Inoue, Kenichi Ikeda, Hitoshi Nakayashiki, Yasuyo Nishimura, Kouhei Ohnishi, Akinori Kiba, Kenji Kai, Yasufumi Hikichi
After invasion into intercellular spaces of tomato plants, the soil-borne plant pathogenic Ralstonia solanacearum strain OE1-1 forms mushroom-shaped biofilms (mushroom-type biofilms, mBFs) on tomato cells, leading to its virulence. The strain OE1-1 produces aryl-furanone secondary metabolites, ralfuranones (A, B, J, K and L), dependent on the quorum sensing (QS) system with methyl 3-hydroxymyristate (3-OH MAME) synthesized by PhcB as a QS signal. Ralfuranones are associated with the feedback loop of the QS system...
July 19, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28693906/reproducible-computer-assisted-quantification-of-myocardial-perfusion-with-contrast-enhanced-ultrasound
#10
Yuanwei Li, Navtej Chahal, Roxy Senior, Meng-Xing Tang
Myocardial perfusion can be quantified by myocardial contrast echocardiography (MCE) and is used for the diagnosis of coronary artery disease (CAD). However, existing MCE quantification software is highly operator dependent and has poor reproducibility and ease of usage. The aim of this study was to develop robust and easy-to-use software that can perform MCE quantification accurately, reproducibly and rapidly. The developed software has the following features: (i) semi-automatic segmentation of the myocardium; (ii) automatic rejection of MCE data with poor image quality; (iii) automatic computation of perfusion parameters such as myocardial blood flow (MBF)...
July 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28693383/saccharomyces-cerevisiae-msa1-mrna-has-a-sequence-for-localization-at-the-bud-tip
#11
Tomoko Takeuchi-Andoh, Yukiko Hayano-Oshiro, Emi Nishiyoshi, Masatoshi Mutazono, Sachiko Hayashi, Tokio Tani
MSA1 mRNA encodes Msa1p, a protein associated with the SCB-binding factor (SBF) and MCB-binding factor (MBF) complex. Msa1p promotes the transcription of G1 phase-specific genes, and is subjected to cell cycle-dependent regulation for its abundance and subcellular localization. MSA1 mRNA and Msa1p levels oscillate in the cell cycle with peaks at the late M/early G1 phase and early G1 phase, respectively. Phosphorylation by CDK1 negatively regulates the nuclear localization of Msa1p. In the present study, we identified MSA1 mRNA as a bud tip-localized mRNA in screening using a Tag-GFP system...
September 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28687967/relationship-of-non-invasive-quantification-of-myocardial-blood-flow-to-arrhythmic-events-in-patients-with-implantable-cardiac-defibrillators
#12
Michael Ghannam, Krasimira Mikhova, Hong Jun Yun, John J Lazarus, Matthew Konerman, Ashraf Saleh, Richard L Weinberg, Ryan Cunnane, Ravi V Shah, Keri M Hiller, Edward P Ficaro, James R Corbett, Venkatesh L Murthy
BACKGROUND: Ischemia contributes to arrhythmogenesis though its role is incompletely understood. Abnormal myocardial perfusion measured by PET imaging may predict ventricular arrhythmias (VAs) in a high-risk population. METHODS: Patients with implantable cardiac defibrillators who had undergone rubidium-82 cardiac PET imaging were identified. Patients were stratified by median MBF and MFR values for analysis. The Cox proportional hazards model was used to assess the impact of myocardial perfusion on survival free of VT independent of critical covariates...
July 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28687542/skeletal-muscle-microvascular-linked-improvements-in-glycemic-control-from-resistance-training-in-individuals-with-type-2-diabetes
#13
Ryan D Russell, Donghua Hu, Timothy Greenaway, Sarah J Blackwood, Renee M Dwyer, James E Sharman, Graeme Jones, Kathryn A Squibb, Aascha A Brown, Petr Otahal, Meg Boman, Hayder Al-Aubaidy, Dino Premilovac, Christian K Roberts, Samuel Hitchins, Stephen M Richards, Stephen Rattigan, Michelle A Keske
OBJECTIVE: Insulin increases glucose disposal in part by enhancing microvascular blood flow (MBF) and substrate delivery to myocytes. Insulin's microvascular action is impaired with insulin resistance and type 2 diabetes. Resistance training (RT) improves glycemic control and insulin sensitivity, but whether this improvement is linked to augmented skeletal muscle microvascular responses in type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS: Seventeen (11 male and 6 female; 52 ± 2 years old) sedentary patients with type 2 diabetes underwent 6 weeks of whole-body RT...
July 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28686634/similarity-measure-and-domain-adaptation-in-multiple-mixture-model-clustering-an-application-to-image-processing
#14
Siow Hoo Leong, Seng Huat Ong
This paper considers three crucial issues in processing scaled down image, the representation of partial image, similarity measure and domain adaptation. Two Gaussian mixture model based algorithms are proposed to effectively preserve image details and avoids image degradation. Multiple partial images are clustered separately through Gaussian mixture model clustering with a scan and select procedure to enhance the inclusion of small image details. The local image features, represented by maximum likelihood estimates of the mixture components, are classified by using the modified Bayes factor (MBF) as a similarity measure...
2017: PloS One
https://www.readbyqxmd.com/read/28685251/corrected-coronary-opacification-decrease-from-coronary-computed-tomography-angiography-validation-with-quantitative-13n-ammonia-positron-emission-tomography
#15
Dominik C Benz, Christoph Gräni, Paola Ferro, Luis Neumeier, Michael Messerli, Mathias Possner, Olivier F Clerc, Catherine Gebhard, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). METHODS AND RESULTS: This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28664576/exercise-versus-vasodilator-stress-limb-perfusion-imaging-for-the-assessment-of-peripheral-artery-disease
#16
Brian P Davidson, J Todd Belcik, Gregory Landry, Joel Linden, Jonathan R Lindner
PURPOSE: Our aim was to determine whether pharmacologic vasodilation is an alternative to exercise stress during limb perfusion imaging for peripheral artery disease (PAD). METHODS: Quantitative contrast-enhanced ultrasound (CEU) perfusion imaging of the bilateral anterior thigh and calf was performed in nine control subjects and nine patients with moderate to severe PAD at rest and during vasodilator stress with dipyridamole. For those who were able, CEU of the calf was then performed during modest plantar flexion exercise (20 watts)...
June 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/28660401/individual-bayesian-information-matrix-for-predicting-estimation-error-and-shrinkage-of-individual-parameters-accounting-for-data-below-the-limit-of-quantification
#17
Thi Huyen Tram Nguyen, Thu Thuy Nguyen, France Mentré
PURPOSE: In mixed models, the relative standard errors (RSE) and shrinkage of individual parameters can be predicted from the individual Bayesian information matrix (MBF). We proposed an approach accounting for data below the limit of quantification (LOQ) in MBF. METHODS: MBF is the sum of the expectation of the individual Fisher information (MIF) which can be evaluated by First-Order linearization and the inverse of random effect variance. We expressed the individual information as a weighted sum of predicted MIF for every possible design composing of measurements above and/or below LOQ...
June 28, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28653394/ranolazine-reduces-repolarization-heterogeneity-in%C3%A2-symptomatic-patients-with-diabetes-and-non-flow-limiting-coronary-artery-stenosis
#18
Ederson Evaristo, Fernando G Stocco, Nishant R Shah, Michael K Cheezum, Jon Hainer, Courtney Foster, Bruce D Nearing, Marcelo Di Carli, Richard L Verrier
BACKGROUND: Experimental evidence suggests that ranolazine decreases susceptibility to ischemia-induced arrhythmias independent of effects on coronary artery blood flow. OBJECTIVE: In symptomatic diabetic patients with non-flow-limiting coronary artery stenosis with diffuse atherosclerosis and/or microvascular dysfunction, we explored whether ranolazine reduces T-wave heterogeneity (TWH), an electrocardiographic (ECG) marker of arrhythmogenic repolarization abnormalities shown to predict sudden cardiac death...
June 27, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28646428/effects-of-carvacrol-on-survival-mesenteric-blood-flow-aortic-function-and-multiple-organ-injury-in-a-murine-model-of-polymicrobial-sepsis
#19
Erdem Kamil Ozer, Mustafa Tugrul Goktas, Aysun Toker, Hulagu Bariskaner, Ceyhan Ugurluoglu, Alper Bektas Iskit
Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Wistar rats were allocated into the following four groups: Sham, CLP, Sham + CRV, and CLP + CRV. The animals were orally administered with CRV (80 mg/kg/day) or vehicle (corn oil; 1 mL/kg/day) for 7 days...
June 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28619736/effects-of-hypercapnia-on-myocardial-blood-flow-in-healthy-human-subjects
#20
Matthieu Pelletier-Galarneau, Robert A deKemp, Chad Rrn Hunter, Ran Klein, Michael Klein, Joel Ironstone, Joseph A Fisher, Terrence Ruddy
Background: Elevation of end-tidal partial pressure of CO2 (PETCO2) increases cerebral and myocardial blood flow (MBF), suggesting that it may be a suitable alternative to pharmacological stress or exercise for myocardial perfusion imaging. The purpose of this study was to document the pharmacodynamics of CO2 on MBF using prospective end-tidal targeting to precisely control arterial PCO2 and use positron emission tomography (PET) to measure the outcome variable, MBF Methods: 10 healthy males underwent serial (82)Rb PET/CT imaging...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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