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https://www.readbyqxmd.com/read/27855349/comparison-of-rest-and-adenosine-stress-quantitative-and-semi-quantitative-myocardial-perfusion-using-magnetic-resonance-in-patients-with-ischemic-heart-disease
#1
Abbas A Qayyum, Faiza Qayyum, Henrik Bw Larsson, Andreas Kjaer, Philip Hasbak, Niels G Vejlstrup, Jens Kastrup
The aim was to compare absolute quantified myocardial perfusion (MP) to semi-quantitative measurements of MP using MRI for detection of ischemia. Twenty-nine patients underwent rest and stress MP imaging obtained by 1.5T MRI and analyzed using own developed software and by commercial available software. Linear regression analysis demonstrated that absolute quantitative data correlated stronger to maxSI (rest: r=0.296, p=.193; stress: r=0.583, p=0.011; myocardial perfusion reserve (MPR): r=0.789, p<0.001; and Δ myocardial blood flow (Δ MBF: r=0...
November 5, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27848160/coronary-flow-reserve-and-relative-flow-reserve-measured-by-n-13-ammonia-pet-for-characterization-of-coronary-artery-disease
#2
Sang-Geon Cho, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Ho-Chun Song, Ju Han Kim, Jae Yeong Cho, Young Joon Hong, Zeenat Jabin, Hee Jeong Park, Geum-Cheol Jeong, Seong Young Kwon, Jin Chul Paeng, Hyeon Sik Kim, Jung-Joon Min, Ernest V Garcia, Henry Hee-Seung Bom
OBJECTIVE: We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS: Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET...
November 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27834683/contribution-of-adenosine-to-the-increase-in-skeletal-muscle-blood-flow-caused-by-manual-acupuncture-in-rats
#3
Hisashi Shinbara, Satomi Nagaoka, Yasuyuki Izutani, Masamichi Okubo, Keisaku Kimura, Kunio Mizunuma, Eiji Sumiya
BACKGROUND AND AIM: Adenosine is believed to play an important role in local acupuncture analgesia. The aim of this study was to investigate the contribution of adenosine to the increase in skeletal muscle blood flow (MBF) caused by manual acupuncture (MA). METHODS: Thirty-two male Sprague-Dawley rats (310-360 g) were anaesthetised and divided into four equal groups (n=8 each): Saline, Saline+MA, Theophylline, and Theophylline+MA. In the two MA groups, the sparrow-pecking MA technique was applied at 30 repetitions per min for 1 min to a depth of 15-18 mm using a stainless steel acupuncture needle (0...
November 10, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/27826897/interactions-between-%C3%AE-adrenergic-vasodilation-and-cervical-sympathetic-nerves-are-mediated-by-%C3%AE-2-adrenoceptors-in-the-rat-masseter-muscle
#4
Hisayoshi Ishii, Toshiya Sato
Neural and humoral autonomic mechanisms may be important in the maintenance of blood flow in the masseter muscle (MBF). However, their interactions remain unclear. In this study, we examined interactions between neural and humoral regulation of MBF and investigated the mechanisms mediating these interactions in urethane-anesthetized rats. Stimulation of the adrenal nerve (AN) projecting to the adrenal medulla increased MBF, and this increase was mediated by β-adrenoceptors. Sectioning of the superior cervical sympathetic trunk (CST) significantly inhibited increases in MBF induced by AN stimulation during high activity in the CST, but not during low activity...
November 8, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27804067/consistent-tracer-administration-profile-improves-test-retest-repeatability-of-myocardial-blood-flow-quantification-with-82-rb-dynamic-pet-imaging
#5
Ran Klein, Adrian Ocneanu, Jennifer M Renaud, Maria C Ziadi, Rob S B Beanlands, Robert A deKemp
OBJECTIVES: Quantification of myocardial blood flow (MBF) and stress/rest flow reserve is used increasingly to diagnose multi-vessel coronary artery disease and micro-vascular disease with PET imaging. However, variability in the measurements may limit physician confidence to direct revascularization therapies based on specific threshold values. This study evaluated the effects of rubidium-82 ((82)Rb) tracer injection profile using a constant-activity-rate (CA) vs a constant-flow-rate (CF) infusion to improve test-retest repeatability of MBF measurements...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27771003/effect-of-diffuse-subendocardial-hypoperfusion-on-left-ventricular-cavity-size-by-13-n-ammonia-perfusion-pet-in-patients-with-hypertrophic-cardiomyopathy
#6
Hulya Yalçin, Ines Valenta, Fatih Yalçin, Celia Corona-Villalobos, Nestor Vasquez, Joshua Ra, Nagehan Kucukler, Abdel Tahari, Iraklis Pozios, Yun Zhou, Martin Pomper, Theodore P Abraham, Thomas H Schindler, M Roselle Abraham
Vasodilator-induced transient left ventricular (LV) cavity dilation by positron emission tomography (PET) is common in patients with hypertrophic cardiomyopathy (HC). Because most patients with PET-LV cavity dilation lack obstructive epicardial coronary artery disease, we hypothesized that vasodilator-induced subendocardial hypoperfusion resulting from microvascular dysfunction underlies this result. To test this hypothesis, we quantified myocardial blood flow (MBF) (subepicardial, subendocardial, and global MBF) and left ventricular ejection fraction (LVEF) in 104 patients with HC without significant coronary artery disease, using (13)NH3-PET...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27704198/diagnostic-value-of-transmural-perfusion-ratio-derived-from-dynamic-ct-based-myocardial-perfusion-imaging-for-the-detection-of-haemodynamically-relevant-coronary-artery-stenosis
#7
Adriaan Coenen, Marisa M Lubbers, Akira Kurata, Atsushi Kono, Admir Dedic, Raluca G Chelu, Marcel L Dijkshoorn, Alexia Rossi, Robert-Jan M van Geuns, Koen Nieman
OBJECTIVES: To investigate the additional value of transmural perfusion ratio (TPR) in dynamic CT myocardial perfusion imaging for detection of haemodynamically significant coronary artery disease compared with fractional flow reserve (FFR). METHODS: Subjects with suspected or known coronary artery disease were prospectively included and underwent a CT-MPI examination. From the CT-MPI time-point data absolute myocardial blood flow (MBF) values were temporally resolved using a hybrid deconvolution model...
October 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27695812/differences-in-body-condition-of-gilts-that-are-maintained-from-mating-to-the-end-of-gestation-affect-mammary-development
#8
C Farmer, M Comi, C R A Duarte, M Vignola, P Charagu, M-F Palin
The goal of this project was to determine if different body conditions in late gestation that are due to varying body conditions at mating affect mammary development and mammary gene expression of gilts. Gilts that were fed ad libitum in the growing period were selected based on their backfat depths to form 3 groups at mating, namely, low backfat (LBF; 12-15 mm; = 14), medium backfat (MBF; 17-19 mm; = 15), and high backfat (HBF; 22-26 mm; = 16). During gestation, LBF, MBF, and HBF gilts were fed approximately 1...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27690364/maximum-bite-force-of-edentulous-patients-before-and-after-dental-implant-rehabilitation-long-term-follow-up-and-facial-type-influence
#9
Ana Cláudia M Melo, Ingrid M Ledra, Rogéria A Vieira, Edivaldo R Coró, Ivete Aparecida de M Sartori
PURPOSE: (1) To evaluate patients' long-term maximum bite force (MBF) after rehabilitation with mandibular implant-supported prosthesis, (2) to assess the influence of facial pattern in MBF, and (3) to evaluate the relation between the dominant chewing side and MBF. MATERIALS AND METHODS: Twenty-nine patients were selected. Pre- (T0) and immediate post-rehabilitation (T1) data of MBF were collected. In a follow-up visit 3 to 5 years after rehabilitation (T2), 24 patients participated...
September 30, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27681955/stress-myocardial-blood-flow-correlates-with-ventricular-function-and-synchrony-better-than-myocardial-perfusion-reserve-a-nitrogen-13-ammonia-pet-study
#10
Luis Eduardo Juárez-Orozco, Erick Alexanderson, Rudi A Dierckx, Hendrikus H Boersma, Johannes L Hillege, Clark J Zeebregts, Myriam M Martínez-Aguilar, Antonio Jordán-Ríos, Ana Gabriela Ayala-German, Niek Prakken, Rene A Tio, Riemer H Slart
BACKGROUND: Cardiac PET quantifies stress myocardial blood flow (MBF) and perfusion reserve (MPR), while ECG-gated datasets can measure components of ventricular function simultaneously. Stress MBF seems to outperform MPR in the detection of significant CAD. However, it is uncertain which perfusion measurement is more related to ventricular function. We hypothesized that stress MBF correlates with ventricular function better than MPR in patients studied for suspected myocardial ischemia...
September 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27624818/the-impact-of-prompt-gamma-compensation-on-myocardial-blood-flow-measurements-with-rubidium-82-dynamic-pet
#11
Ian S Armstrong, Matthew J Memmott, Christine M Tonge, Parthiban Arumugam
BACKGROUND: Rubidium-82 myocardial perfusion imaging is a well-established technique for assessing myocardial ischemia. With continuing interest on myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurements, there is a requirement to fully appreciate the impact of technical aspects of the process. One such factor for rubidium-82 is prompt gamma compensation (PGC). This study aims to assess the impact of PGC on MBF and MFR calculated from dynamic Rb-82 data. METHODS: Dynamic rest and stress images were acquired on a Siemens Biograph mCT and reconstructed with and without PGC in 50 patients (29 male)...
September 13, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27611710/clinical-relevance-of-pet-myocardial-blood-flow-quantification
#12
Lucia Leccisotti, Mariadea Lavalle, Alessandro Giordano
Until a few years ago, myocardial perfusion imaging (MPI) using positron-emission tomography (PET) and the absolute quantification of myocardial blood flow (MBF) was limited to research institutions. Following an increase in the number of PET scanner installations and in the availability of perfusion tracers that do not have to be produced by an on-site cyclotron and commercial software for MBF quantification, a more widespread clinical use of MBF quantification with PET can be expected. This article aims to provide a comprehensive overview of the advantages of MBF quantification with PET highlighting the potential applications in several clinical settings, from patients with cardiovascular risk factors and early coronary artery disease (CAD) to patients with multi-vessel or myocardial disease...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27611709/positron-emission-tomography-myocardial-blood-flow-quantification-in-hypertrophic-cardiomyopathy
#13
Roberto Sciagrà
In the setting of hypertrophic cardiomyopathy (HCM), ischemia plays a possibly under-evaluated role. In particular, a large body of evidence indicates that structural and functional abnormalities in the coronary microcirculation contribute to myocardial ischemia and are key elements for HCM pathophysiology and clinical evolution. Measurement of myocardial blood flow (MBF) at rest and under maximal hyperemia (hMBF) by means of perfusion positron-emission tomography (PET) is the most effective way to assess microvascular dysfunction in humans...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27611708/non-invasive-measurement-of-coronary-flow-reserve-uniqueness-of-radionuclide-methods-and-alternative-techniques
#14
Matteo Bauckneht, Roberta Piva, Giulia Ferrarazzo, Valentina Ceriani, Ambra Buschiazzo, Silvia Morbelli, Cecilia Marini, Gianmario Sambuceti
Over the last several decades, radionuclide Myocardial Perfusion Imaging (MPI) has been a mainstay for the evaluation of coronary artery disease (CAD), based on the assumption that a detailed knowledge of stenosis localization and severity is not sufficient for clinical decision making. Furthermore, radionuclide MPI diagnostic accuracy has been implemented by the assessment of Coronary Flow Reserve (CFR) and Myocardial Blood Flow (MBF), as quantitative indexes of stenosis severity and surrogates of total ischaemic burden...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27609817/integrated-myocardial-perfusion-imaging-diagnostics-improve-detection-of-functionally-significant-coronary-artery-stenosis-by-13n-ammonia-positron-emission-tomography
#15
Joo Myung Lee, Chee Hae Kim, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Ki-Hyun Jeon, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Sang-Hoon Na, Jung-Min Ahn, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress myocardial blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) diagnostic panel, including stress MBF, coronary flow reserve (CFR), and relative flow reserve (RFR) in conjunction with relative perfusion defect (PD) assessments to better detect functionally significant coronary artery stenosis...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27604183/a-look-locker-acquisition-scheme-for-quantitative-myocardial-perfusion-imaging-with-fair-arterial-spin-labeling-in-humans-at-3-tesla
#16
Graeme A Keith, Christopher T Rodgers, Michael A Chappell, Matthew D Robson
PURPOSE: A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath-hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability. METHODS: A flow-sensitive alternating inversion recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27585716/prevalence-of-ischaemia-in-patients-with-a-chronic-total-occlusion-and-preserved-left-ventricular-ejection-fraction
#17
Wijnand J Stuijfzand, Roel S Driessen, Pieter G Raijmakers, Mischa T Rijnierse, Joren Maeremans, Maurits R Hollander, Adriaan A Lammertsma, Albert C van Rossum, Jo Dens, Alexander Nap, Niels van Royen, Paul Knaapen
AIMS: Previous studies on invasive assessment of collateral function in patients with a chronic total occlusion (CTO) have displayed only a limited increase in collateral flow and high occurrence of coronary steal during pharmacological stress. This could question the necessity for ischaemia testing prior to revascularization of CTOs in the presence of myocardial viability. The purpose of the present study was to determine the prevalence of perfusion impairments in patients with a CTO as assessed by [(15)O]H2O positron emission tomography (PET)...
September 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27585576/spect-myocardial-blood-flow-quantitation-toward-clinical-use-a-comparative-study-with-13-n-ammonia-pet-myocardial-blood-flow-quantitation
#18
Bailing Hsu, Lien-Hsin Hu, Bang-Hung Yang, Lung-Ching Chen, Yen-Kung Chen, Chien-Hsin Ting, Guang-Uei Hung, Wen-Sheng Huang, Tao-Cheng Wu
OBJECTIVES: The aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of (99m)Tc-Sestamibi (MIBI) single photon emission computed tomography (SPECT) compared with (13)N-Ammonia (NH3) position emission tomography (PET) on the same cohorts. BACKGROUND: Recent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available...
September 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27583385/quantitative-perfusion-analysis-of-first-pass-contrast-enhancement-kinetics-application-to-mri-of-myocardial-perfusion-in-coronary-artery-disease
#19
Sohae Chung, Binita Shah, Pippa Storey, Sohah Iqbal, James Slater, Leon Axel
PURPOSE: Perfusion analysis from first-pass contrast enhancement kinetics requires modeling tissue contrast exchange. This study presents a new approach for numerical implementation of the tissue homogeneity model, incorporating flexible distance steps along the capillary (NTHf). METHODS: The proposed NTHf model considers contrast exchange in fluid packets flowing along the capillary, incorporating flexible distance steps, thus allowing more efficient and stable calculations of the transit of tracer through the tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27546353/a-comparison-of-infarct-mass-by-cardiac-magnetic-resonance-and-real-time-myocardial-perfusion-echocardiography-as-predictors-of-major-adverse-cardiac-events-following-reperfusion-for-st-elevation-myocardial-infarction
#20
Charles J Lenz, Sahar S Abdelmoneim, Nandan S Anavekar, Thomas A Foley, Lara F Nhola, Runqing Huang, Jae K Oh, Sharon L Mulvagh
PURPOSE: Infarct mass as assessed by myocardial-delayed enhancement imaging on cardiac magnetic resonance (CMR) and myocardial blood flow as assessed by real time myocardial perfusion echocardiography (RT-MPE) have been shown to predict adverse events following ST elevation myocardial infarction (STEMI). There has been no published comparison of quantitative assessment using these modalities as predictors of clinical outcomes to date. We compared RT-MPE with CMR for prediction of cardiac events in reperfused STEMI patients...
August 21, 2016: Echocardiography
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