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Adriaan Coenen, Marisa M Lubbers, Akira Kurata, Atsushi Kono, Admir Dedic, Raluca G Chelu, Marcel L Dijkshoorn, Alexia Rossi, Robert-Jan M van Geuns, Koen Nieman
OBJECTIVES: To investigate the additional value of transmural perfusion ratio (TPR) in dynamic CT myocardial perfusion imaging for detection of haemodynamically significant coronary artery disease compared with fractional flow reserve (FFR). METHODS: Subjects with suspected or known coronary artery disease were prospectively included and underwent a CT-MPI examination. From the CT-MPI time-point data absolute myocardial blood flow (MBF) values were temporally resolved using a hybrid deconvolution model...
October 4, 2016: European Radiology
C Farmer, M Comi, C R A Duarte, M Vignola, P Charagu, M-F Palin
The goal of this project was to determine if different body conditions in late gestation that are due to varying body conditions at mating affect mammary development and mammary gene expression of gilts. Gilts that were fed ad libitum in the growing period were selected based on their backfat depths to form 3 groups at mating, namely, low backfat (LBF; 12-15 mm; = 14), medium backfat (MBF; 17-19 mm; = 15), and high backfat (HBF; 22-26 mm; = 16). During gestation, LBF, MBF, and HBF gilts were fed approximately 1...
August 2016: Journal of Animal Science
Ana Cláudia M Melo, Ingrid M Ledra, Rogéria A Vieira, Edivaldo R Coró, Ivete Aparecida de M Sartori
PURPOSE: (1) To evaluate patients' long-term maximum bite force (MBF) after rehabilitation with mandibular implant-supported prosthesis, (2) to assess the influence of facial pattern in MBF, and (3) to evaluate the relation between the dominant chewing side and MBF. MATERIALS AND METHODS: Twenty-nine patients were selected. Pre- (T0) and immediate post-rehabilitation (T1) data of MBF were collected. In a follow-up visit 3 to 5 years after rehabilitation (T2), 24 patients participated...
September 30, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Luis Eduardo Juárez-Orozco, Erick Alexanderson, Rudi A Dierckx, Hendrikus H Boersma, Johannes L Hillege, Clark J Zeebregts, Myriam M Martínez-Aguilar, Antonio Jordán-Ríos, Ana Gabriela Ayala-German, Niek Prakken, Rene A Tio, Riemer H Slart
BACKGROUND: Cardiac PET quantifies stress myocardial blood flow (MBF) and perfusion reserve (MPR), while ECG-gated datasets can measure components of ventricular function simultaneously. Stress MBF seems to outperform MPR in the detection of significant CAD. However, it is uncertain which perfusion measurement is more related to ventricular function. We hypothesized that stress MBF correlates with ventricular function better than MPR in patients studied for suspected myocardial ischemia...
September 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Ian S Armstrong, Matthew J Memmott, Christine M Tonge, Parthiban Arumugam
BACKGROUND: Rubidium-82 myocardial perfusion imaging is a well-established technique for assessing myocardial ischemia. With continuing interest on myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurements, there is a requirement to fully appreciate the impact of technical aspects of the process. One such factor for rubidium-82 is prompt gamma compensation (PGC). This study aims to assess the impact of PGC on MBF and MFR calculated from dynamic Rb-82 data. METHODS: Dynamic rest and stress images were acquired on a Siemens Biograph mCT and reconstructed with and without PGC in 50 patients (29 male)...
September 13, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Lucia Leccisotti, Mariadea Lavalle, Alessandro Giordano
Until a few years ago, myocardial perfusion imaging (MPI) using positron-emission tomography (PET) and the absolute quantification of myocardial blood flow (MBF) was limited to research institutions. Following an increase in the number of PET scanner installations and in the availability of perfusion tracers that do not have to be produced by an on-site cyclotron and commercial software for MBF quantification, a more widespread clinical use of MBF quantification with PET can be expected. This article aims to provide a comprehensive overview of the advantages of MBF quantification with PET highlighting the potential applications in several clinical settings, from patients with cardiovascular risk factors and early coronary artery disease (CAD) to patients with multi-vessel or myocardial disease...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Roberto Sciagrà
In the setting of hypertrophic cardiomyopathy (HCM), ischemia plays a possibly under-evaluated role. In particular, a large body of evidence indicates that structural and functional abnormalities in the coronary microcirculation contribute to myocardial ischemia and are key elements for HCM pathophysiology and clinical evolution. Measurement of myocardial blood flow (MBF) at rest and under maximal hyperemia (hMBF) by means of perfusion positron-emission tomography (PET) is the most effective way to assess microvascular dysfunction in humans...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Matteo Bauckneht, Roberta Piva, Giulia Ferrarazzo, Valentina Ceriani, Ambra Buschiazzo, Silvia Morbelli, Cecilia Marini, Gianmario Sambuceti
Over the last several decades, radionuclide Myocardial Perfusion Imaging (MPI) has been a mainstay for the evaluation of coronary artery disease (CAD), based on the assumption that a detailed knowledge of stenosis localization and severity is not sufficient for clinical decision making. Furthermore, radionuclide MPI diagnostic accuracy has been implemented by the assessment of Coronary Flow Reserve (CFR) and Myocardial Blood Flow (MBF), as quantitative indexes of stenosis severity and surrogates of total ischaemic burden...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Joo Myung Lee, Chee Hae Kim, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Ki-Hyun Jeon, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Sang-Hoon Na, Jung-Min Ahn, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress myocardial blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) diagnostic panel, including stress MBF, coronary flow reserve (CFR), and relative flow reserve (RFR) in conjunction with relative perfusion defect (PD) assessments to better detect functionally significant coronary artery stenosis...
September 2016: Circulation. Cardiovascular Imaging
Graeme A Keith, Christopher T Rodgers, Michael A Chappell, Matthew D Robson
PURPOSE: A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath-hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability. METHODS: A flow-sensitive alternating inversion recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Wijnand J Stuijfzand, Roel S Driessen, Pieter G Raijmakers, Mischa T Rijnierse, Joren Maeremans, Maurits R Hollander, Adriaan A Lammertsma, Albert C van Rossum, Jo Dens, Alexander Nap, Niels van Royen, Paul Knaapen
AIMS: Previous studies on invasive assessment of collateral function in patients with a chronic total occlusion (CTO) have displayed only a limited increase in collateral flow and high occurrence of coronary steal during pharmacological stress. This could question the necessity for ischaemia testing prior to revascularization of CTOs in the presence of myocardial viability. The purpose of the present study was to determine the prevalence of perfusion impairments in patients with a CTO as assessed by [(15)O]H2O positron emission tomography (PET)...
September 1, 2016: European Heart Journal Cardiovascular Imaging
Bailing Hsu, Lien-Hsin Hu, Bang-Hung Yang, Lung-Ching Chen, Yen-Kung Chen, Chien-Hsin Ting, Guang-Uei Hung, Wen-Sheng Huang, Tao-Cheng Wu
OBJECTIVES: The aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of (99m)Tc-Sestamibi (MIBI) single photon emission computed tomography (SPECT) compared with (13)N-Ammonia (NH3) position emission tomography (PET) on the same cohorts. BACKGROUND: Recent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available...
September 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Sohae Chung, Binita Shah, Pippa Storey, Sohah Iqbal, James Slater, Leon Axel
PURPOSE: Perfusion analysis from first-pass contrast enhancement kinetics requires modeling tissue contrast exchange. This study presents a new approach for numerical implementation of the tissue homogeneity model, incorporating flexible distance steps along the capillary (NTHf). METHODS: The proposed NTHf model considers contrast exchange in fluid packets flowing along the capillary, incorporating flexible distance steps, thus allowing more efficient and stable calculations of the transit of tracer through the tissue...
2016: PloS One
Charles J Lenz, Sahar S Abdelmoneim, Nandan S Anavekar, Thomas A Foley, Lara F Nhola, Runqing Huang, Jae K Oh, Sharon L Mulvagh
PURPOSE: Infarct mass as assessed by myocardial-delayed enhancement imaging on cardiac magnetic resonance (CMR) and myocardial blood flow as assessed by real time myocardial perfusion echocardiography (RT-MPE) have been shown to predict adverse events following ST elevation myocardial infarction (STEMI). There has been no published comparison of quantitative assessment using these modalities as predictors of clinical outcomes to date. We compared RT-MPE with CMR for prediction of cardiac events in reperfused STEMI patients...
August 21, 2016: Echocardiography
Jennifer M Renaud, Kathy Yip, Jean Guimond, Mikaël Trottier, Philippe Pibarot, Eric Turcotte, Conor Maguire, Lucille Lalonde, Karen Y Gulenchyn, Troy H Farncombe, Gerald Wisenberg, Jonathan B Moody, Benjamin C Lee, Steven C Port, Timothy Turkington, Rob S B Beanlands, Robert deKemp
: Three-dimensional (3D) mode imaging is the current standard for positron emission tomography-computed tomography (PET-CT) systems. Dynamic imaging for quantification of myocardial blood flow (MBF) with short-lived tracers, such as Rb-82-chloride (Rb-82), requires accuracy to be maintained over a wide range of isotope activities and scanner count-rates. We propose new performance standard measurements to characterize the dynamic range of PET systems for accurate quantitative imaging...
August 18, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Christoph Gräni, Dominik C Benz, Mathias Possner, Olivier F Clerc, Fran Mikulicic, Jan Vontobel, Julia Stehli, Tobias A Fuchs, Aju P Pazhenkottil, Oliver Gaemperli, Philipp A Kaufmann, Ronny R Buechel
OBJECTIVE: To provide data on the value of fused cardiac hybrid imaging with coronary computed tomography angiography (CCTA) and positron emission tomography myocardial perfusion imaging (PET-MPI) in patients with complex coronary artery anomalies (CCAA). DESIGN/SETTING: This is a retrospective, single-center study. PATIENTS: Seven consecutive patients with CCAA (mean 57 ± 7 y, 86% were male) who underwent clinically indicated hybrid CCTA/PET-MPI between 2005 and 2015 in our clinic were included...
August 19, 2016: Congenital Heart Disease
Helga Castagnoli, Cecilia Ferrantini, Raffaele Coppini, Alessandro Passeri, Katia Baldini, Valentina Berti, Franco Cecchi, Iacopo Olivotto, Roberto Sciagrà
AIMS: Myocardial blood flow <1.1 mL/min/g following dipyridamole (Dip-MBF) assessed by positron emission tomography (PET) was identified in 2003 as an important outcome predictor in hypertrophic cardiomyopathy (HCM), based on scans performed in the 90s. However, such extreme Dip-MBF impairment is rarely observed in contemporary cohorts. We, therefore, reassessed the Dip-MBF threshold defining high-risk HCM patients. METHODS: Dip-MBF was measured using (13)N-ammonia in 100 HCM consecutive patients, prospectively enrolled and followed for 4...
August 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Thomas Hellmut Schindler, Ines Valenta, Sahar Mirpour, Wael Marashdeh
BACKGROUND: There is increasing interest in cardiovascular imaging modalities in the detection of subclinical and clinically-manifest coronary artery disease (CAD) to improve cardiovascular outcome in these patients. METHODS: SPECT/CT and PET/CT can be applied for the assessment of myocardial perfusion and myocardial blood flow (MBF) quantification in CAD detection and characterization, while CT is predominantly used to identify coronary plaque burden and epicardial narrowing...
August 13, 2016: Current Pharmaceutical Design
Wijnand J Stuijfzand, Pieter G Raijmakers, Roel S Driessen, Adriaan A Lammertsma, Albert C van Rossum, Alexander Nap, Yolande Appelman, Jorrit S Lemkes, Maarten A van Leeuwen, Niels van Royen, Paul Knaapen
AIMS: A randomised clinical trial of bioresorbable vascular scaffold (BVS) vs. metal drug-eluting stent (DES) was initiated, using positron emission tomography (PET) perfusion imaging to assess the effects of both treatments on (hyperaemic) myocardial blood flow (MBF) and coronary flow reserve (CFR) over a three-year period (VANISH trial). In the present study, early, i.e., after one month, MBF and CFR are reported. METHODS AND RESULTS: Sixty patients (45 men [75%], 55±7 years) with a documented single-vessel type A or B1 lesion were included in this single-blind randomised clinical trial...
2016: EuroIntervention
Roni Nielsen, Anders Jorsal, Peter Iversen, Lars Tolbod, Kirsten Bouchelouche, Jens Sørensen, Hendrik Johannes Harms, Allan Flyvbjerg, Hans Erik Bøtker, Henrik Wiggers
BACKGROUND: In type 2 diabetes, a decrease in myocardial glucose uptake (MGU) may lower glucose oxidation and contribute to progression of chronic heart failure (CHF). However, it is unsettled whether CHF patients with prediabetes have abnormal MGU and myocardial blood flow (MBF) during normal physiological conditions. METHODS AND RESULTS: We studied 35 patients with CHF and reduced left ventricular ejections fraction (34 ± 9%) without overt T2D (mean HbA1c: 40 ± 4 mmol/mol) using echocardiography and quantitative measurements of MGU by 18F-FDG-PET and perfusion by 15O-H2O-PET...
July 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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