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https://www.readbyqxmd.com/read/28205113/cardiac-pet-ct-with-rb-82-optimization-of-image-acquisition-and-reconstruction-parameters
#1
P Chilra, S Gnesin, G Allenbach, M Monteiro, J O Prior, L Vieira, J A Pires Jorge
BACKGROUND: Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in (82)Rb PET/CT quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Rest and stress list-mode dynamic (82)Rb PET acquisition data from 10 patients without myocardial flow defects and 10 patients with myocardial blood flow defects were reconstructed retrospectively...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28202246/analysis-of-myocardial-perfusion-parameters-in-an-ex-vivo-porcine-heart-model-using-third-generation-dual-source-ct
#2
Gert Jan Pelgrim, Taylor M Duguay, J Marco A Stijnen, Akos Varga-Szemes, Sjoerd Van Tuijl, U Joseph Schoepf, Matthijs Oudkerk, Rozemarijn Vliegenthart
PURPOSE: To evaluate the relationship between fractional flow reserve (FFR)-determined coronary artery stenosis severity and myocardial perfusion parameters derived from dynamic myocardial CT perfusion imaging (CTP) in an ex-vivo porcine heart model. METHODS: Six porcine hearts were perfused according to Langendorff. Circulatory parameters such as arterial blood flow (ABF) (L/min), mean arterial pressure (MAP) (mmHg) and heart rate (bpm) were monitored. Using an inflatable cuff and monitored via a pressure wire, coronary artery stenoses of different FFR grades were created (no stenosis, FFR = 0...
February 3, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28176182/rb-82-pet-ct-left-ventricular-mass-to-volume-ratios
#3
Andrew Van Tosh, Nathaniel Reichek, C David Cooke, Christopher J Palestro, Kenneth J Nichols
Left ventricular (LV) mass:volume ratios indexed to body size (Mi/Vi) provide risk stratification for cardiac events. We sought to determine whether Rb-82 PET mass and volume indices are similar to MRI normal values for low likelihood subjects, and whether abnormal indices are related to abnormal myocardial blood flow (MBF). Data were analyzed retrospectively for 194 patients referred for rest/stress Rb-82 PET. LV EF, volume and mass values were calculated and mass:volume ratios were indexed to patients' height and weight...
February 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28168868/oesophageal-doppler-guided-optimization-of-cardiac-output-does-not-increase-visceral-microvascular-blood-flow-in-healthy-volunteers
#4
Thomas P Heinink, David J Read, William K Mitchell, Ashish Bhalla, Jonathan N Lund, Bethan E Phillips, John P Williams
BACKGROUND: Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF). We used contrast-enhanced ultrasound (CEUS) to assess whether ODM-guided optimization of CO altered MBF. METHODS: Sixteen healthy male volunteers (62 ± 3·4 years) were studied. Baseline measurements of CO were recorded via ODM...
February 6, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28160262/comparison-between-the-summed-difference-score-and-myocardial-blood-flow-measured-by-13-n-ammonia
#5
Raffaele Giubbini, Alessia Peli, Elisa Milan, Roberto Sciagrà, Luca Camoni, Domenico Albano, Mattia Bertoli, Mattia Bonacina, Federica Motta, Massimo Statuto, Carlo Alberto Rodella, Antonio De Agostini, Raffaella Calabretta, Francesco Bertagna
BACKGROUND: Both the myocardial perfusion pattern and myocardial blood flow (MBF) are used to assess patients with suspected coronary artery disease (CAD). The aim of this study was to compare the perfusion pattern (using the summed difference score [SDS]) to MBF in a consecutive group of patients undergoing PET/CT with 13 N-ammonia ((13)NH3). METHODS: 47 consecutive patients, aged 65 ± 12 years (42 men) with known or suspected CAD, underwent vasodilator stress/rest PET/CT with (13)NH3 for clinical indications...
February 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28152238/assessment-of-segmental-myocardial-blood-flow-and-myocardial-perfusion-reserve-by-adenosine-stress-myocardial-arterial-spin-labeling-perfusion-imaging
#6
Andrew J Yoon, Hung Phi Do, Steven Cen, Michael W Fong, Farhood Saremi, Mark L Barr, Krishna S Nayak
PURPOSE: To determine the feasibility of measuring increases in myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) on a per-segment basis using arterial spin labeled (ASL) magnetic resonance imaging (MRI) with adenosine vasodilator stress in normal human myocardium. MATERIALS AND METHODS: Myocardial ASL scans at rest and during adenosine infusion were incorporated into a routine 3T MR adenosine-induced vasodilator stress protocol and were performed in 10 healthy human volunteers...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28138813/noninvasive-pet-quantitative-myocardial-blood-flow-with-regadenoson-for-assessing-cardiac-allograft-vasculopathy-in-orthotopic-heart-transplantation-patients
#7
Miguel Hernandez Pampaloni, Uttam M Shrestha, Maria Sciammarella, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: Risk stratification and early detection of cardiac allograft vasculopathy (CAV) is essential in orthotopic heart transplantation (OHT) patients. This study assesses the changes in myocardial blood flow (MBF) noninvasively in OHT patients using quantitative cardiac PET with regadenoson. METHODS: Twelve patients (Group 1) (8 males, 4 females, mean age 55 ± 7 years) with no history of post OHT myocardial ischemia were enrolled 5.4 ± 2.0 years after OHT...
January 30, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28137454/residual-activity-correction-in-quantitative-myocardial-perfusion-13-n-ammonia-pet-imaging-a-study-in-post-mi-patients
#8
George Markousis-Mavrogenis, Luis Eduardo Juárez-Orozco, Erick Alexanderson
BACKGROUND/INTRODUCTION/AIM: Positron Emission Tomography (PET) is the gold standard for quantification of Myocardial Blood Flow (MBF). A standard PET scan is acquired in two phases (rest and pharmacological stress). (13)N-ammonia is a perfusion radiotracer that may show residual activity which may affect MBF estimation during the second phase of the scan. An algorithm for Residual Activity Correction (RAC) is available when reconstruction is performed using Syngo MBF (by Siemens). The aim of this study was to evaluate differentes in MBF estimation with and without RAC by Syngo MBF in patients with a previous MI using (13)N-ammonia PET...
January 27, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28130886/classification-of-hemodynamically-significant-stenoses-from-dynamic-ct-perfusion-and-cta-myocardial-territories
#9
Marco Giordano, Dirk H J Poot, Adriaan Coenen, Theo van Walsum, Michela Tezza, Koen Nieman, Wiro J Niessen
PURPOSE: Myocardial blood flow (MBF) obtained by dynamic CT perfusion (CTP) has been recently introduced to assess hemodynamic significance of coronary stenosis in coronary artery disease. The diagnostic performance of dynamic CTP MBF is limited due to subjective interpretation of MBF maps and MBF variations caused by physiological, methodological and technical issues. In this paper we introduce a novel method to quantify the hypoperfused volume (HPV) in myocardial territories derived from CT angiography (CTA) in order to overcome the limitations of current dynamic CTP MBF analysis methods...
January 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28127331/effect-of-modified-widman-flap-surgery-on-maximum-molar-bite-force-a-clinical-trial
#10
Jaber Yaghini, Vahid Sakhaei Manesh, Noushin Janbakhsh
OBJECTIVES: The purpose of the present study was to evaluate the effect of modified Widman flap (MWF) surgery (as a periodontal treatment procedure) on maximum bite force (MBF; as an indicator of patient function). MATERIALS AND METHODS: In this clinical trial, 24 patients were examined for their MBF before and at one, four and eight weeks after their MWF surgery. These recordings along with the patients' demographics were analyzed using repeated measures ANOVA at a significance level of 0...
September 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28125995/analysis-of-spatiotemporal-fidelity-in-quantitative-3d-first-pass-perfusion-cardiovascular-magnetic-resonance
#11
Lukas Wissmann, Alexander Gotschy, Claudio Santelli, Kerem Can Tezcan, Sandra Hamada, Robert Manka, Sebastian Kozerke
BACKGROUND: Whole-heart first-pass perfusion cardiovascular magnetic resonance (CMR) relies on highly accelerated image acquisition. The influence of undersampling on myocardial blood flow (MBF) quantification has not been systematically investigated yet. In the present work, the effect of spatiotemporal scan acceleration on image reconstruction accuracy and MBF error was studied using a numerical phantom and validated in-vivo. METHODS: Up to 10-fold scan acceleration using k-t PCA and k-t SPARSE-SENSE was simulated using the MRXCAT CMR numerical phantom framework...
January 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28122597/beyond-the-entomological-inoculation-rate-characterizing-multiple-blood-feeding-behavior-and-plasmodium-falciparum-multiplicity-of-infection-in-anopheles-mosquitoes-in-northern-zambia
#12
Smita Das, Mbanga Muleba, Jennifer C Stevenson, Julia C Pringle, Douglas E Norris
BACKGROUND: A commonly used measure of malaria transmission intensity is the entomological inoculation rate (EIR), defined as the product of the human biting rate (HBR) and sporozoite infection rate (SIR). The EIR excludes molecular parameters that may influence vector control and surveillance strategies. The purpose of this study was to investigate Anopheles multiple blood feeding behavior (MBF) and Plasmodium falciparum multiplicity of infection (MOI) within the mosquito host in Nchelenge District, northern Zambia...
January 26, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28111212/global-quantification-of-left-ventricular-myocardial-perfusion-at-dynamic-ct-imaging-prognostic-value
#13
Felix G Meinel, Julian L Wichmann, U Joseph Schoepf, Francesca Pugliese, Ullrich Ebersberger, Gladys G Lo, Yeon Hyeon Choe, Yining Wang, Christian Tesche, Sabrina Segreto, Wolfgang G Kunz, Kolja M Thierfelder, Fabian Bamberg, Carlo N De Cecco
BACKGROUND: There is no published data on the prognostic value of global myocardial perfusion values at stress dynamic CT myocardial perfusion imaging (CTMPI). METHODS: Data of 144 patients from 6 centers who had undergone coronary CT angiography (coronary CTA) and CTMPI were assessed. Coronary CTA studies were acquired at rest; CTMPI was performed under vasodilator stress. Coronary CTA data were evaluated for coronary artery stenosis (≥50% luminal narrowing) on a per-vessel basis...
January 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28067589/novel-bioflocculant-produced-by-salt-tolerant-alkaliphilic-strain-oceanobacillus-polygoni-hg6-and-its-application-in-tannery-wastewater-treatment
#14
Jing Li, Yue-Qing Yun, Li Xing, Lei Song
The optimized production of MBF-HG6, which is a novel salt-tolerant alkaliphilic bioflocculant produced by Oceanobacillus polygoni with its application in tannery wastewater treatment was investigated in this study. It was found the optimal carbon source, nitrogen source, cation, and initial pH of the medium for bioflocculant production were starch, urea, Fe(2+), and pH 9.0, respectively. The best stability in the temperature range was from 0 to 80°C and the purified MBF-HG6 contained polysaccharides of 81...
January 9, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28058674/quantitative-myocardial-blood-flow-imaging-with-integrated-time-of-flight-pet-mr
#15
Tanja Kero, Jonny Nordström, Hendrik J Harms, Jens Sörensen, Håkan Ahlström, Mark Lubberink
BACKGROUND: The use of integrated PET-MR offers new opportunities for comprehensive assessment of cardiac morphology and function. However, little is known on the quantitative accuracy of cardiac PET imaging with integrated time-of-flight PET-MR. The aim of the present work was to validate the GE Signa PET-MR scanner for quantitative cardiac PET perfusion imaging. Eleven patients (nine male; mean age 59 years; range 46-74 years) with known or suspected coronary artery disease underwent (15)O-water PET scans at rest and during adenosine-induced hyperaemia on a GE Discovery ST PET-CT and a GE Signa PET-MR scanner...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28050630/myocardial-blood-flow-and-left-ventricular-functional-reserve-in-hypertrophic-cardiomyopathy-a-13-nh3-gated-pet-study
#16
Roberto Sciagrà, Raffaella Calabretta, Fabrizio Cipollini, Alessandro Passeri, Angelo Castello, Franco Cecchi, Iacopo Olivotto, Alberto Pupi
INTRODUCTION: Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF) reserve in HCM patients undergoing dipyridamole (Dip) PET. METHODS: Resting and stress (13)NH3 dynamic as well as gated PET were performed in 34 HCM patients...
January 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28046589/tu-h-campus-iep3-04-evaluation-of-changes-in-quantitative-ultrasound-parameters-during-prostate-radiotherapy
#17
M Najafi, A El Kaffas, B Han, D Cooper, S Hancock, D Hristov
PURPOSE: Clarity Autoscan ultrasound monitoring system allows acquisition of raw radiofrequency (RF) ultrasound data prior and during radiotherapy. This enables the computation of 3D Quantitative Ultrasound (QUS) tissue parametric maps from. We aim to evaluate whether QUS parameters undergo changes with radiotherapy and thus potentially be used as early predictors and/or markers of treatment response in prostate cancer patients. METHODS: In-vivo evaluation was performed under IRB protocol to allow data collection in prostate patients treated with VMAT whereby prostate was imaged through the acoustic window of the perineum...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27998007/mandibular-movements-and-bite-force-in-alzheimer-s-disease-before-and-after-new-denture-insertion
#18
C H Campos, G R Ribeiro, F Stella, R C M Rodrigues Garcia
Chewing impairment has been observed in elders with Alzheimer's disease (AD); however, it is unknown whether oral rehabilitation can improve their masticatory function. This study evaluated the influence of new removable prostheses on chewing function of patients with AD. Participants using removable dentures were divided into two groups: patients with mild AD (77·2 ± 5·8 years, n = 16) and controls (76·0 ± 4·4, n = 16). All participants received general dental treatment and new total and/or partial removable prostheses...
March 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27997375/impact-of-motion-and-partial-volume-effects-correction-on-pet-myocardial-perfusion-imaging-using-simultaneous-pet-mr
#19
Yoann Petibon, Nicolas J Guehl, Timothy G Reese, Behzad Ebrahimi, Marc D Normandin, Timothy M Shoup, Nathaniel M Alpert, Georges El Fakhri, Jinsong Ouyang
PET is an established modality for myocardial perfusion imaging (MPI) which enables quantification of absolute myocardial blood flow (MBF) using dynamic imaging and kinetic modeling. However, heart motion and partial volume effects (PVE) significantly limit the spatial resolution and quantitative accuracy of PET MPI. Simultaneous PET-MR offers a solution to the motion problem in PET by enabling MR-based motion correction of PET data. The aim of this study was to develop a motion and PVE correction methodology for PET MPI using simultaneous PET-MR, and to assess its impact on both static and dynamic PET MPI using (18)F-Flurpiridaz, a novel (18)F-labeled perfusion tracer...
January 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27989579/plasma-palmitoylethanolamide-pea-as-a-potential-biomarker-for-impaired-coronary-function
#20
Alessandra Quercioli, Federico Carbone, Aldo Bonaventura, Luca Liberale, Zoltan Pataky, Aurélien Thomas, Sébastien Lenglet, Estelle Lauer, Alain Golay, Franco Dallegri, Vincenzo Di Marzo, Thomas H Schindler, Fabrizio Montecucco
BACKGROUND: Among endocannabinoid (EC)-related mediators, Oleoyl-ethanolamide (OEA) and Palmitoyl-ethanolamide (PEA), two endogenous PPARα agonists with lipolytic and anti-inflammatory action, respectively, are being actively investigated. Here, we assessed the potential association between plasma levels of PEA and OEA and coronary function in a cohort including normal, overweight, obese, and morbidly obese (MOB) individuals. METHODS: Myocardial perfusion and endothelium-related myocardial blood flow (MBF) responses to cold pressor test (CPT) and during pharmacological vasodilation with dipyridamole were measured with (13)N-ammonia positron emission tomography/computed tomography...
March 15, 2017: International Journal of Cardiology
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