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endothelial keratoplasty

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https://www.readbyqxmd.com/read/27907157/human-bone-derived-collagen-for-the-development-of-an-artificial-corneal-endothelial-graft-in-vivo-results-in-a-rabbit-model
#1
Natalia Vázquez, Manuel Chacón, Carlos A Rodríguez-Barrientos, Jesús Merayo-Lloves, Miguel Naveiras, Begoña Baamonde, Jose F Alfonso, Iriana Zambrano-Andazol, Ana C Riestra, Álvaro Meana
Corneal keratoplasty (penetrating or lamellar) using cadaveric human tissue, is nowadays the main treatment for corneal endotelial dysfunctions. However, there is a worldwide shortage of donor corneas available for transplantation and about 53% of the world's population have no access to corneal transplantation. Generating a complete cornea by tissue engineering is still a tough goal, but an endothelial lamellar graft might be an easier task. In this study, we developed a tissue engineered corneal endothelium by culturing human corneal endothelial cells on a human purified type I collagen membrane...
2016: PloS One
https://www.readbyqxmd.com/read/27906816/intraocular-pressure-measurements-after-descemet-membrane-endothelial-keratoplasty
#2
Anna-Karina B Maier, Enken Gundlach, Milena Pahlitzsch, Johannes Gonnermann, Caitlin Corkhill, Eckart Bertelmann, Antonia M Joussen, Matthias K J Klamann, Necip Torun
PURPOSE: Intraocular pressure (IOP) elevation occurs regularly after Descemet membrane endothelial keratoplasty (DMEK). This study evaluated the effect of central corneal thickness (CCT) on the IOP after DMEK. PATIENTS AND METHODS: This prospective study recorded the IOP of 46 eyes from 46 patients preoperatively, and then 1 and 3 months after DMEK. IOP measurement was performed by noncontact pneumatic tonometry (NCT), iCare, Goldmann applanation tonometry (GAT), and dynamic contour tonometry (DCT)...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27893525/outcomes-of-descemet-membrane-endothelial-keratoplasty-in-patients-with-previous-glaucoma-surgery
#3
Carolina Aravena, Fei Yu, Sophie X Deng
PURPOSE: To evaluate outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with previous trabeculectomy or a drainage device. METHODS: This is a retrospective study of 108 consecutive DMEK performed between October 2013 and December 2015. All eyes were divided into 3 groups: surgical treatment (ST) group, medical treatment (MT) group, and control group. Visual improvement, endothelial cell loss, and postoperative complications, including rejection, graft failure, and intraocular pressure elevation (≥25 mm Hg) were evaluated...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27885526/twelve-year-follow-up-of-penetrating-keratoplasty
#4
Takashi Ono, Sosuke Ishiyama, Takeshi Hayashidera, Yosai Mori, Ryohei Nejima, Kazunori Miyata, Shiro Amano
PURPOSE: To evaluate the long-term outcomes of penetrating keratoplasty (PKP) according to the corneal disease diagnosis and the number of PKP procedures performed. METHODS: Five-hundred-and-nine eyes from 403 patients who underwent PKP at Miyata Eye Hospital in Japan from 1998 through 2014, were included in this study. Medical charts were retrospectively examined to ascertain the corneal disease diagnosis and the period of graft survival. Graft survival rates were compared among various corneal disease diagnoses and among the number of PKP procedures performed...
November 24, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27873063/-a%C3%A2-new-technique-to-facilitate-donor-preparation-for-dmek-surgery
#5
P W Rieck, T Engels
BACKGROUND: Descemet membrane endothelial keratoplasty (DMEK) is becoming more and more the method of choice to treat corneal endothelial diseases in specialized centers. The reasons that prevent this technique from becoming widespread are the delicate donor tissue preparation. By inverting the curvature of the cornea from convex to concave after mounting onto an artificial anterior chamber, we developed a combined manual delamination and hydrodissection technique, which allows a rapid and endothelium-preserving method of separating donor Descemet membranes from the underlying stroma...
November 21, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27873061/-opacification-of-a-hydrophilic-acrylic-intraocular-lens-after-dmek-a-material-analysis
#6
C Milojcic, C Latz, T Tandogan, G U Auffarth, F G Holz, C Y Choi, R Khoramnia
OBJECTIVE: Calcification of a hydrophilic intraocular lens (IOL) is a rare complication. We report on the analysis of an opacified IOL, which was explanted 2 years after Descemet membrane endothelial keratoplasty (DMEK), using light and scanning electron microscopy, X‑ray spectroscopy and investigations on the optical bench. METHODS: In October 2012 a patient with pseudophakic keratopathy and Fuchs endothelial dystrophy underwent DMEK with double rebubbling. Due to primary graft failure the patient underwent penetrating keratoplasty in January 2013...
November 21, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27871779/intraocular-pressure-measurement-after-dsaek-by-icare-goldmann-applanation-and-dynamic-contour-tonometry-a-comparative-study
#7
A Achiron, O Blumenfeld, H Avizemer, L Karmona, G Leybowich, V Man, E Bartov, Z Burgansky-Eliash
PURPOSE: Corneal thickness inevitably increases following Descemet's stripping automated endothelial keratoplasty (DSAEK), owing to the addition of a donor graft. The current study compares different devices in assessing post-DSAEK intraocular pressure (IOP). METHODS: We compared IOP values measured by the Goldmann tonometry (GAT), iCare rebound tonometry (iCare) and Pascal dynamic contour tonometry (PDCT) in eyes following DSAEK. Agreement between measurements was calculated with correlation analysis and Bland-Altman plots...
November 18, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27861311/effect-of-trabeculotomy-on-corneal-endothelial-cell-loss-in-cases-of-postpenetrating-keratoplasty-glaucoma
#8
Ayaka Kusakabe, Naoki Okumura, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita, Kazuhiko Mori
PURPOSE: The aim of this study was to evaluate the effect of trabeculotomy (TLO) on glaucoma and endothelial cell loss after penetrating keratoplasty (PK). METHODS: A retrospective study was conducted on consecutive patients who underwent PK and in whom more than 24 months of follow-up was available. Patients were categorized into the PK+TLO group [ie, TLO for post-PK glaucoma (n = 10)] and the PK group [PK alone (n = 73)]. Intraocular pressure (IOP) was evaluated during each follow-up examination...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861306/enhancing-dmek-success-by-identifying-optimal-levels-of-trypan-blue-dye-application-to-donor-corneal-tissue
#9
Parag A Majmudar, Lauren Johnson
PURPOSE: The purpose of this study was to determine the correct concentration and duration of application of trypan blue dye to Descemet membrane endothelial keratoplasty (DMEK) donor corneal tissue before transplant to enhance visibility while minimizing damage to the tissue. METHODS: Corneas were precut for DMEK using an 8-mm punch, and each was stained with either 0.06% or 0.15% trypan blue for a duration of 1, 3, or 5 minutes. After staining, each tissue was placed in balanced salt solution and observed to determine how quickly the stain faded from the tissue using a grading system...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27858161/two-photon-optical-microscopy-imaging-of-endothelial-keratoplasty-grafts
#10
Marco Lombardo, Mohit Parekh, Sebastiano Serrao, Alessandro Ruzza, Stefano Ferrari, Giuseppe Lombardo
PURPOSE: To investigate the microstructure of endothelial keratoplasty grafts using two-photon optical microscopy. METHODS: Six endothelial keratoplasty grafts obtained from human donor corneoscleral tissues and prepared by submerged hydrodissection technique were imaged by two-photon optical microscopy. In each graft, two liquid bubbles were created in order to investigate the presence of a conserved cleavage plane regardless of the volume of posterior stroma that remained attached to Descemet's membrane (DM); the first bubble (bubble A) was generated under DM and the second bubble (bubble B) injection was done in order to obtain a layer of deep stroma that kept the two bubbles separated...
November 17, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27853009/outcome-of-transplanted-donor-corneas-with-more-than-6-h-of-death-to-preservation-time
#11
Ashik Mohamed, Sunita Chaurasia, Prashant Garg
PURPOSE: In tropical countries, physicians are skeptic in using corneas with death-to-preservation time (DTPT) >6 h, concerns being endothelial cell viability and microbial contamination on prolonged DTPT. The objective of the study was to investigate these concerns by analyzing the outcomes of corneal transplants performed using donor corneas with DTPT >6 h. MATERIALS AND METHODS: The study was a retrospective case series of 65 transplants performed in 2013 with donor corneas that had DTPT >6 h (range, 6...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27836829/one-year-outcome-after-descemet-membrane-endothelial-keratoplasty-dmek-comparing-sulfur-hexafluoride-sf6-20-versus-100-air-for-anterior-chamber-tamponade
#12
Friederike Schaub, Philip Enders, Katharina Snijders, Silvia Schrittenlocher, Sebastian Siebelmann, Ludwig M Heindl, Björn O Bachmann, Claus Cursiefen
PURPOSE: To investigate 1-year clinical outcome and complication rates following Descemet membrane endothelial keratoplasty (DMEK) with sulfur hexafluoride 20% (SF620%) anterior chamber tamponade compared with conventionally used 100% air for primary graft attachment during DMEK surgery. METHODS: Records of 1112 consecutive DMEKs were reviewed retrospectively and grouped by anterior chamber tamponade used during DMEK surgery (SF620% vs 100% air). Outcome measures included intraocular pressure (IOP), best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD) and central corneal thickness (CCT) at 1, 3, 6 and 12 months after DMEK surgery...
November 11, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27824383/360-degree-iris-burns-following-conductive-keratoplasty
#13
Hanefi Çakir, Selim Genç, Emre Güler
PURPOSE: The authors report a case with multiple iris burns after conductive keratoplasty to correct hyperopia. METHODS: Case report. RESULTS: A 52-year-old woman with hyperopia had a previous conductive keratoplasty procedure and underwent a conductive keratoplasty re-treatment 6 months later. Postoperatively, she presented with 360-degree iris burns in both eyes that were correlated with the corneal conductive keratoplasty scars. In addition, specular microscopy revealed decreased endothelial cell density for both eyes...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27821104/publication-trends-in-corneal-transplantation-a-bibliometric-analysis
#14
Evre Pekel, Gökhan Pekel
BACKGROUND: Our aim was to demonstrate the publication trends of corneal transplantation in the last decade. METHODS: All of the keratoplasty research articles, letters, case reports, reviews and meeting abstracts published between January 2006 and December 2015 indexed on the Thomson Reuters Web of Knowledge were evaluated. A bibliometric filter was used to capture keratoplasty related publications by using the key words 'keratoplasty', 'corneal transplantation' or 'keratoprosthesis' in the 'title' selection mode...
November 8, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27820748/triple-procedure-cataract-extraction-intraocular-lens-implantation-and-corneal-graft
#15
Yoshinori Oie, Kohji Nishida
PURPOSE OF REVIEW: Corneal triple procedures consist of combined keratoplasty surgery and cataract surgery. Currently, anterior lamellar keratoplasty, endothelial keratoplasty, and conventional penetrating keratoplasty, are very often simultaneously performed with cataract surgery. The present article reviews the recent advances and current developments in corneal triple procedures. RECENT FINDINGS: Many new findings have been reported. Core vitrectomy before host trephination and retroillumination during continuous curvilinear capsulorhexis has enabled us to perform penetrating keratoplasty triple procedures more safely...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27811568/enhancing-descemet-membrane-endothelial-keratoplasty-in-postvitrectomy-eyes-with-the-use-of-pars-plana-infusion
#16
Nir Sorkin, Adi Einan-Lifshitz, Zach Ashkenazy, Tanguy Boutin, Mahmood Showail, Armand Borovik, Murad Alobthani, Clara C Chan, David S Rootman
PURPOSE: To present a modified surgical technique to perform Descemet membrane endothelial keratoplasty (DMEK) in previously vitrectomized eyes and to analyze its safety and efficacy. METHODS: A retrospective analysis of previously vitrectomized eyes that underwent DMEK at Toronto Western Hospital was performed. The modified DMEK technique that was used included placement of a posterior pars plana infusion to reduce fluctuations in the anterior chamber depth and its excessive deepening...
November 2, 2016: Cornea
https://www.readbyqxmd.com/read/27811564/impact-of-surgical-learning-curve-in-descemet-membrane-endothelial-keratoplasty-on-visual-acuity-gain
#17
Guillaume Debellemanière, Emmanuel Guilbert, Romain Courtin, Christophe Panthier, Patrick Sabatier, Damien Gatinel, Alain Saad
PURPOSE: To evaluate the learning curve for graft preparation and graft unrolling during Descemet membrane endothelial keratoplasty (DMEK) and to assess the evolution of visual acuity gain and percentage cell loss with experience. METHODS: The first 109 DMEK procedures performed by a single surgeon (A.S.) at the Rothschild Foundation Ophthalmology Hospital in Paris, France, between March 2012 and November 2014 were included. Best-corrected visual acuity and endothelial cell density were recorded preoperatively and again 1 week, 1 month, 3 months, and 6 months after DMEK...
November 2, 2016: Cornea
https://www.readbyqxmd.com/read/27811562/outcomes-of-descemet-stripping-automated-endothelial-keratoplasty-in-toxic-anterior-segment-syndrome-after-phacoemulsification
#18
Manpreet Kaur, Jeewan S Titiyal, Ruchita Falera, Tarun Arora, Namrata Sharma
PURPOSE: To evaluate the visual and anatomical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with toxic anterior segment syndrome (TASS). METHODS: Fourteen eyes of 14 patients who underwent clear corneal DSAEK for endothelial decompensation secondary to TASS after phacoemulsification were included in this prospective study. Intraoperative surgical difficulties were noted. Preoperative and postoperative evaluation of visual acuity, slit-lamp examination, intraocular pressure, central corneal thickness, and endothelial count was performed in all cases...
November 2, 2016: Cornea
https://www.readbyqxmd.com/read/27805532/visual-rehabilitation-after-penetrating-keratoplasty
#19
Leyla Asena, Dilek D Altınörs
OBJECTIVES: Here, our aim was to report our treatment strategies and their results performed for visual rehabilitation after penetrating keratoplasty. MATERIALS AND METHODS: The medical records of 98 patients (54 male/44 female), with results from 104 eyes, who underwent penetrating keratoplasty between January 2013 and January 2015 at the Baskent University Faculty of Medicine, Department of Ophthalmology were reviewed. Patient age, indication for penetrating keratoplasty, interventions performed for visual rehabilitation, follow-up duration, topographic and refractive astigmatism at the end of follow-up, and final best corrected visual acuity results were recorded...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27802912/systematic-review-comparing-penetrating-keratoplasty-and-deep-anterior-lamellar-keratoplasty-for-management-of-keratoconus
#20
REVIEW
Christin Henein, Mayank A Nanavaty
AIM: Perception of reduced incidence of graft rejection after deep anterior lamellar keratoplasty (DALK) has attracted many surgeons towards this technique in keratoconus. This review aims to compare the visual, refractive and graft outcomes after penetrating keratoplasty (PK) and DALK for keratoconus. METHODS: Electronic searches of PubMed, MEDLINE, EMBASE, Latin American and Caribbean Health Sciences Literature database (LILACS), metaRegister of Controlled Trials (mRCT), ClinicalTrial...
October 29, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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