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endothelial keratoplasty

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https://www.readbyqxmd.com/read/28225492/clinical-application-of-ticl-implantation-for-ametropia-following-deep-anterior-lamellar-keratoplasty-for-keratoconus-a-consort-compliant-article
#1
Qin Qin, Liping Yang, Zifang He, Zhenping Huang
BACKGROUND: This study aimed to investigate the clinical application of phakic toric intraocular collamer lens (TICL) implantation in treating ametropia following deep anterior lamellar keratoplasty (DALK) for patients with keratoconus, especially the effectiveness and safety of high astigmatism and indications of TICL implantation after corneal transplantation. METHODS: Using the self-controlled case series observation approach, 9 patients with ametropia (9 eyes) who underwent DALK surgery for keratoconus 1...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28211878/pre-descemets-endothelial-keratoplasty-the-pdek-clamp-for-successful-pdek
#2
H S Dua, D G Said
PurposeTo design and produce a clamp that enables good handling of donor sclera-corneal disks, allows air to be injected in the corneal stroma and consistently provides pre-Descemets endothelial keratoplasty (PDEK) tissue by creation of a type-1 big bubble (BB) avoiding a type-2BB by shutting the fenestrations in the periphery of the pre-Descemets layer and preventing escape of air.Patients and methodsA clamp with spring loaded handles attached to two rings of 9 mm diameter and 1 mm width with a side port for insertion of a needle for air injection was designed and produced...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28181931/avoiding-complications-associated-with-preloaded-ultrathin-descemet-stripping-automated-endothelial-keratoplasty
#3
Mohit Parekh, Alessandro Ruzza, Bernhard Steger, Colin E Willoughby, Stefano Ferrari, Diego Ponzin, Stephen B Kaye, Vito Romano
No abstract text is available yet for this article.
February 8, 2017: Cornea
https://www.readbyqxmd.com/read/28181929/corneal-endothelial-cell-integrity-in-precut-human-donor-corneas-enhanced-by-autocrine-vasoactive-intestinal-peptide
#4
Shay-Whey M Koh, Timothy Coll, Dante Gloria, Nicholas Sprehe
PURPOSE: To demonstrate that vasoactive intestinal peptide (VIP), a corneal endothelial (CE) cell autocrine factor, maintains the integrity of corneal endothelium in human donor corneoscleral explants precut for endothelial keratoplasty. METHODS: Twelve paired human donor corneoscleral explants used as control versus VIP-treated explants (10 nM, 30 minutes, 37°C) were shipped (4°C) to the Lions Eye Institute for Transplantation and Research for precutting (Moria CBM-ALTK Keratome), shipped back to the laboratory, and cultured in ciliary neurotrophic factor (CNTF, 0...
February 8, 2017: Cornea
https://www.readbyqxmd.com/read/28160608/is-there-evidence-for-a-surgeon-learning-curve-for-endothelial-keratoplasty-in-australia
#5
Miriam C Keane, Richard Ad Mills, Douglas J Coster, Keryn A Williams
IMPORTANCE: Expected outcomes from endokeratoplasty may vary with surgeon experience. BACKGROUND: We explored whether a surgeon learning curve exists for Descemet stripping endothelial keratoplasties (manual or automated) performed in Australia. DESIGN: Prospective cohort study; various clinical settings. PARTICIPANTS: 2139 recipients of 2615 endothelial grafts, registered by 85 surgeons between January 2006 and December 2013...
February 4, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28160068/descemet-membrane-endothelial-keratoplasty-for-graft-failure-following-penetrating-keratoplasty
#6
Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thabo Lapp, Thomas Reinhard, Philip Maier
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) is superior to penetrating keratoplasty (PK) in terms of visual rehabilitation, intraoperative safety and risk of rejection. Therefore, it seems reasonable to perform DMEK in eyes with endothelial failure following PK. We herein report our first clinical results. METHODS: Nineteen eyes with endothelial graft failure following PK were treated with DMEK. The majority of these eyes (12) had limited visual potential...
February 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28151811/effect-of-trabeculotomy-on-corneal-endothelial-cell-loss-in-cases-of-after-penetrating-keratoplasty-glaucoma
#7
Ayaka Kusakabe, Naoki Okumura, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita, Kazuhiko Mori
PURPOSE: The aim of this study was to evaluate the effect of trabeculotomy (TLO) on glaucoma and endothelial cell loss after penetrating keratoplasty (PK). METHODS: A retrospective study was conducted on consecutive patients who underwent PK and in whom more than 24 months of follow-up was available. Patients were categorized into the PK+TLO group [ie, TLO for post-PK glaucoma (n = 10)] and the PK group [PK alone (n = 73)]. Intraocular pressure (IOP) was evaluated during each follow-up examination...
March 2017: Cornea
https://www.readbyqxmd.com/read/28149669/survey-of-experts-on-current-endothelial-keratoplasty-techniques
#8
Winston Chamberlain, Ariana Austin, Mark Terry, Bennie H Jeng, Jennifer Rose-Nussbaumer
OBJECTIVE: To survey cornea specialists' opinions on different endothelial keratoplasty techniques and to gauge the perceived need for and utility of a randomized controlled trial (RCT) comparing them. METHODS: A short survey was distributed to a group of cornea specialists at the Endothelial Keratoplasty Group meeting at the American Academy of Ophthalmology meeting in November 2015. RESULTS: Thirty-three of 80 practicing surgeons present at the EKG meeting participated in the survey, yielding a response rate of 41%...
October 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28138772/effect-of-corneal-collagen-crosslinking-on-subsequent-deep-anterior-lamellar-keratoplasty-dalk-in-keratoconus
#9
Friederike Schaub, Philip Enders, Björn O Bachmann, Ludwig M Heindl, Claus Cursiefen
PURPOSE: The purpose was to investigate the impact of ultraviolet light corneal collagen crosslinking (UV-CXL) on the success rate and clinical outcome of subsequent deep anterior lamellar keratoplasty (DALK) in eyes with keratoconus (KC). METHODS: Medical records of 101 consecutive eyes with KC scheduled for big-bubble DALK surgery were screened retrospectively for details of previously performed UV-CXL, as well as intra- and postoperative complications of DALK surgery...
January 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28129302/evaluation-and-quality-assessment-of-prestripped-preloaded-descemet-membrane-endothelial-keratoplasty-grafts
#10
Khoa D Tran, Philip K Dye, Kelly Odell, Joshua Galloway, Christopher G Stoeger, Michael D Straiko, Mark A Terry
PURPOSE: To determine graft quality and feasibility of Descemet membrane endothelial keratoplasty (DMEK) grafts that are prestripped and preloaded into injectors by eye bank technicians before shipping to surgeons. METHODS: DMEK grafts (n = 31) were prepared from donor corneas and preloaded into Straiko Modified Jones tubes and set inside viewing chambers filled with 20 mL of Optisol-GS. Preloaded grafts were evaluated using specular microscopy and slit-lamp biomicroscopy...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28129299/pupillary-abnormalities-in-descemet-membrane-endothelial-keratoplasty-after-nearly-full-tamponade
#11
Francisco Arnalich-Montiel, Ane Pérez-Sarriegui, Gorka Lauzirika, Laura Porrua, José Luis Hernández-Verdejo
PURPOSE: To describe the incidence, risk factors, and management of pupillary abnormalities after anterior chamber (AC) full air or gas tamponade in Descemet membrane endothelial keratoplasty (DMEK) without pupillary block. METHODS: In this retrospective case series, clinical records of 25 patients (32 eyes) who underwent DMEK were reviewed for pupillary abnormalities and iris morphology. All patients had nearly full intracameral tamponade with air or 20% SF6 at the end of surgery without default air release postoperatively...
March 2017: Cornea
https://www.readbyqxmd.com/read/28129297/toxic-anterior-segment-syndrome-inadvertent-administration-of-intracameral-lidocaine-1-and-phenylephrine-2-5-preserved-with-10-benzalkonium-chloride-during-cataract-surgery
#12
Brett P Bielory, Ayesha Shariff, Rehan M Hussain, Jose Antonio Bermudez-Magner, Sander R Dubovy, Kendall E Donaldson
PURPOSE: To report 3 patients with corneal decompensation and anterior uveitis within 24 hours of cataract surgery from a single ambulatory surgery center using intracameral lidocaine HCl 1% and phenylephrine 2.5% inadvertently preserved with 10% benzalkonium chloride. METHODS: This case series describes 3 patients who underwent traditional cataract extraction with a significant decrease in visual acuity in the immediate postoperative period resulting in secondary surgical intervention for corneal decompensation in 2 patients...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28129295/asymptomatic-infection-in-decompensated-full-thickness-corneal-grafts-referred-for-repeat-penetrating-keratoplasty
#13
Yoav Nahum, Pia Leon, Benedetta Azzurra Ricci-Filipovic, Davide Camposampiero, Diego Ponzin, Massimo Busin
PURPOSE: We report a case series of asymptomatic infections affecting failed corneal grafts in patients referred for repeat penetrating keratoplasty (PK). METHODS: In this retrospective, noncomparative, interventional case series, we reviewed the medical records of all repeat PK procedures performed at Villa Serena-Villa Igea private Hospitals (Forlì, Italy) between January 2011 and March 2016. Specifically, preoperative and postoperative slit-lamp examinations, and the results of histological and bacteriological examinations, were noted...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28118661/trinucleotide-repeat-expansion-in-the-transcription-factor-4-tcf4-gene-leads-to-widespread-mrna-splicing-changes-in-fuchs-endothelial-corneal-dystrophy
#14
Eric D Wieben, Ross A Aleff, Xiaojia Tang, Malinda L Butz, Krishna R Kalari, Edward W Highsmith, Jin Jen, George Vasmatzis, Sanjay V Patel, Leo J Maguire, Keith H Baratz, Michael P Fautsch
Purpose: To identify RNA missplicing events in human corneal endothelial tissue isolated from Fuchs' endothelial corneal dystrophy (FECD). Methods: Total RNA was isolated and sequenced from corneal endothelial tissue obtained during keratoplasty from 12 patients with FECD and 4 patients undergoing keratoplasty or enucleation for other indications. The length of the trinucleotide repeat (TNR) CTG in the transcription factor 4 (TCF4) gene was determined using leukocyte-derived DNA analyzed by a combination of Southern blotting and Genescan analysis...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28116630/corneal-transplantation-study-of-the-data-of-a-regional-eye-bank-for-the-year-2013-and-analysis-of-the-evolution-of-the-adverse-events-reported-in-france-since-2010
#15
Anne-Sophie Gauthier, Marie Castelbou, Mélanie Bidaut Garnier, Joëlle Pizzuto, Stephan Roux, Philippe Gain, Fabienne Pouthier, Bernard Delbosc
To analyze the data of the adverse events collected in a single major eye bank (EFS Bourgogne Franche Comté, Besançon, France) for the year 2013 and to report the French data of biovigilance provided by the French National Agency for Medicines and Health Products Safety (ANSM) between 2010 and 2013. we have set up a study of adverse events in 2013, in collaboration with a single eye bank (EFS Bourgogne Franche Comté, Besançon, France). A survey was sent to the surgeon for each delivered corneal button by the eye bank in 2013...
January 23, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28114695/-functional-results-and-graft-failure-after-repeat-keratoplasty
#16
S Blug, B Seitz, A Langenbucher, N Szentmáry
Background and Purpose Keratoplasty is the oldest and most successful transplantation method in man. Despite the immunological privilege of the cornea, the graft fails in up to 10 % of patients, depending on corneal disease, quality of donor tissue and patient compliance, and repeat keratoplasty may then be necessary. The aim of this study was to verify factors which affect the functional result and graft survival after repeat keratoplasty. Patients and Methods In this single centre, consecutive retrospective case series, patients were included who were treated at Department of Ophthalmology, Saarland University Medical Centre with repeat keratoplasty between January 1st 2001 and December 31st 2010...
January 23, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28114585/immune-cells-on-the-corneal-endothelium-of-an-allogeneic-corneal-transplantation-rabbit-model
#17
Elena Koudouna, Naoki Okumura, Yugo Okazaki, Shinichiro Nakano, Ryota Inoue, Nigel J Fullwood, Junko Hori, Shigeru Kinoshita, Noriko Koizumi
Purpose: Corneal endothelial cell density undergoes a progressive decrease for many years after transplantation, eventually threatening patients with late endothelial failure. The purpose of this study was to investigate the possibility of an immunologic response in successfully grafted corneal endothelium. Methods: The corneal endothelium of patients who had undergone corneal transplantation was evaluated by specular microscopy. Rabbit models were subjected to penetrating keratoplasty (PK) with either syngeneic or allogeneic corneal transplants and Descemet's stripping endothelial keratoplasty (DSEK) with allogeneic corneal transplants...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28101654/cell-viability-and-shock-wave-amplitudes-in-the-endothelium-of-porcine-cornea-exposed-to-ultrashort-laser-pulses
#18
Syed Asad Hussain, Carles Milián, Caroline Crotti, Laura Kowalczuk, Fatima Alahyane, Zacaria Essaïdi, Arnaud Couairon, Marie-Claire Schanne-Klein, Karsten Plamann
PURPOSE: Some forms of keratoplasty assisted by ultrashort-pulse lasers require performing laser cuts close to the endothelium, which requires the knowledge of "safe" values concerning incision depth and pulse energy preserving endothelial cell viability. Our study aims to determine the thresholds for cell death in porcine corneas exposed to ultrashort laser pulses, in terms of laser pulse energy and nearness of the impacts to the endothelium. METHODS: Using a laboratory laser set-up, lamellar cuts were induced while varying pulse energies and distances from the endothelium...
January 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28094043/incidence-and-clinical-course-of-immune-reactions-after-descemet-membrane-endothelial-keratoplasty-retrospective-analysis-of-1000-consecutive-eyes
#19
Deniz Hos, Onur Tuac, Friederike Schaub, Tisha P Stanzel, Silvia Schrittenlocher, Martin Hellmich, Björn O Bachmann, Claus Cursiefen
PURPOSE: To analyze the incidence and clinical course of graft rejection episodes after Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective analysis of a consecutive, interventional case series. PARTICIPANTS: One thousand eyes that underwent DMEK from July 2011 through August 2015 at the Department of Ophthalmology, University of Cologne. METHODS: All cases with follow-up of at least 1 month were included (mean follow-up, 18...
January 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28079691/lutein-and-brilliant-blue-based-dye-for-donor-preparation-and-transplantation-in-descemet-membrane-endothelial-keratoplasty
#20
Sebastian Siebelmann, Mario Matthaei, Robert Hörster, Claus Cursiefen, Björn Bachmann
PURPOSE: Trypan blue (TB) is used for visualization of the endothelium-Descemet membrane graft during Descemet membrane endothelial keratoplasty (DMEK). However, TB is assumed to have a dose-dependent toxic effect on the corneal endothelium. We retrospectively compared a lutein/zeaxanthin and Brilliant Blue (LZ/BB)-based dye for preparation and transplantation of the graft in DMEK to TB. METHODS: In 20 patients, a dye composed of 1% LZ /0.025% BB was used, and in 22 patients, 0...
January 11, 2017: Cornea
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