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endothelial keratoplasty

Nicolas Cesário Pereira, Evandro Ribeiro Diniz, Ramon Coral Ghanem, Ruy Cunha Filho, Tatiana Moura Prazeres, Walton Nose, Adriana Dos Santos Forseto
PURPOSE: This report describes the use of Descemet membrane endothelial keratoplasty for the management of endothelial decompensation after multifocal intraocular lens implantation. METHODS: In this retrospective study, we reviewed and assessed the surgical outcomes of 9 patients (9 eyes) who underwent Descemet membrane endothelial keratoplasty after multifocal intraocular lens implantation. RESULTS: Corneal edema occurred due to Fuchs endothelial corneal dystrophy (n=3), pseudophakic bullous keratopathy (n=3), Descemet's membrane detachment (n=2), and toxic anterior segment syndrome (n=1)...
June 2018: Arquivos Brasileiros de Oftalmologia
Yusuf Koçluk, Burcu Kasım, Emine Alyamaç Sukgen, Ayşe Burcu
PURPOSE: To evaluate the complications and clinical results of Descemet membrane endothelial keratoplasty (DMEK) in patients with endothelial failure that occurred during the learning curve of a surgeon. METHODS: Fifty eyes of 50 patients with DMEK and ≥6 months of follow-up were included. The patients were divided into the first 25 (group 1) and the second 25 (group 2) procedures performed by the surgeon. Best corrected visual acuity (BCVA), central corneal thickness (CCT), unfolding time of the Descemet membrane (DM) graft, and intraoperative and postoperative complications were compared between groups...
June 2018: Arquivos Brasileiros de Oftalmologia
Shmuel Graffi, Pia Leon, Michael Mimouni, Yoav Nahum, Rossella Spena, Leila Mattioli, Massimo Busin
PURPOSE: To evaluate the relationship between graft thickness/regularity and visual outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: Records of post-DSAEK patients who were examined by anterior segment optical coherence tomography at "Villa Igea" Private Hospital (Forlì, Italy) since April 2015 were reviewed. Pachymetric and elevation maps of both host cornea and graft were analyzed. Graft regularity was determined based on the root mean square error (RMSE) of the graft pachymetric measurements taken 3 and 6 mm from the center and the RMSE of the corneal elevation measurements at its posterior and interface surfaces...
June 19, 2018: Cornea
Mark A P Fajgenbaum, Nick Kopsachilis, Emma J Hollick
PURPOSE: To report surgical outcomes and endothelial cell density (ECD) trends up to 2 years post-operatively in the first cohort of eyes undergoing Descemet's membrane endothelial keratoplasty (DMEK) for low-to-moderate risk indications at our UK centre. Tight corneal sutures were used to ensure high intraoperative pressure from intracameral air for 10-min and to maintain a good post-operative air fill. Outcomes were compared to a prior series at our unit of similar eyes having Descemet's stripping endothelial keratoplasty (DSEK)...
June 19, 2018: Eye
Priya M Mathews, Kristina Lindsley, Anthony J Aldave, Esen K Akpek
PURPOSE: The purpose of this focused review was to explore the etiologies of corneal blindness worldwide and compare them with the indications and type of keratoplasties (eg, full-thickness penetrating keratoplasty, anterior lamellar keratoplasty, or endothelial keratoplasty) performed. METHODS: A literature search of the articles published in the top 10 journals (based on the Altmetrics score) relevant to corneal transplantation within the past 20 years was performed to determine how the focus within corneal transplantation has changed over time...
June 14, 2018: Cornea
Sebastian Siebelmann, Mario Matthaei, Ludwig M Heindl, Björn O Bachmann, Claus Cursiefen
BACKGROUND: The surgical treatment of corneal dystrophies develops rapidly as the use of lamellar corneal grafting techniques continue. While penetrating keratoplasty was the gold standard for treating a variety of dystrophies a few years ago, the affected layers of the cornea can, nowadays, be selectively replaced or ablated using laser technology. Of particular importance for these methods is optical coherence tomography, which has recently been integrated into surgical microscopes (MI-OCT)...
June 2018: Klinische Monatsblätter Für Augenheilkunde
Sepehr Feizi, Amir Faramarzi, Ali Masoudi, Amir A Azari, Amirreza Veisi
PURPOSE: To evaluate agreement between IOP measured using the ocular response analyzer (ORA) versus using the Goldmann applanation tonometer (GAT) in patients treated by Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: This prospective, case-control study comprised 38 normal eyes and 37 post-DSAEK eyes. IOP was measured using the GAT (IOPGAT). The ORA was used to measure corneal biomechanics and cornea-compensated IOP (IOPCC). Corneal hysteresis (CH), corneal resistance factor, and IOP measurements of the 2 groups were compared...
June 5, 2018: Cornea
Marianne O Price, Marek Lisek, Meagan Kelley, Matthew T Feng, Francis W Price
PURPOSE: To determine whether graft orientation during insertion affects Descemet membrane endothelial keratoplasty (DMEK) outcomes. METHODS: This was a retrospective analysis of 754 consecutive DMEK cases performed by 2 experienced surgeons to treat Fuchs dystrophy. Both surgeons used an intraocular lens insertor. One surgeon always inserted the tissue scrolled endothelium outward (group 1, n = 245). The other surgeon tested 3 methods: endothelium-outward scroll configuration (group 2, n = 161), endothelium-inward trifold configuration (group 3, n = 172), and trifold configuration with concurrent use of an anterior chamber maintainer (group 4, n = 176)...
May 31, 2018: Cornea
Lara R Newman, David L DeMill, Dorian A Zeidenweber, Zachary M Mayko, Alex J Bauer, Khoa D Tran, Michael D Straiko, Mark A Terry
PURPOSE: To describe the technique, advantages, and early complication rates of using Descemet membrane endothelial keratoplasty (DMEK) donor tissue that is prestained and preloaded into an injector at the eye bank and delivered in a storage medium to the surgeon for transplantation 1 to 2 days later. METHODS: A total of 111 eyes with endothelial failure underwent DMEK using donors that were prestripped, prestained, S-stamped, and preloaded into a Straiko modified Jones tube and delivered in an Optisol-filled viewing chamber 1 to 2 days later...
May 31, 2018: Cornea
Viridiana Kocaba, Kishore Reddy Katikireddy, Ilene Gipson, Marianne O Price, Francis W Price, Ula V Jurkunas
Importance: The number and size of guttae increase over time in Fuchs endothelial corneal dystrophy (FECD); however, the association between these physical parameters and disease pathogenesis is unclear. Objective: To determine the role of guttae in corneal endothelial cell function. Design, Settings, and Participants: In an in vitro model, cells from a human corneal endothelial cell line, HCENC-21T, were seeded on decellularized normal (n = 30) and FECD (n = 70) endothelial basement (Descemet) membranes (DMs)...
May 31, 2018: JAMA Ophthalmology
Norihiro Yamada, Takahiko Hayashi, Kentaro Yuda, Toshiki Shimizu, Itaru Oyakawa, Hidenori Takahashi, Naoko Kato
Purpose: To evaluate the clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) for vitrectomized eyes that underwent pars plana vitrectomy (PPV) and transscleral-sutured intraocular lens (IOL) implantation. Methods: In this retrospective study, DMEK cases were reviewed from medical records and divided into two groups: the eyes after PPV and transscleral-sutured IOL implantation (vitrectomized group) and the eyes with in-the-bag IOL implantation (control group) prior to DMEK...
2018: Journal of Ophthalmology
Rafaella Nascimento E Silva, Lycia Maria Martins Pinho Pedral Sampaio, Aline Silveira Moriyama, Nicolas Cesário Pereira, Mark Lane, Hudson Vergennes da Silva, Adriana Dos Santos Forseto
PURPOSE: Donated corneas are classified as tectonic if there are defects within any layers of the cornea which would prevent a satisfactory visual outcome after transplantation. This study aimed to evaluate whether some tectonic corneas have sufficient endothelial characteristics to allow their use in posterior lamellar keratoplasty, and explored their reclassification for use in this sight-improving procedure. METHODS: A retrospective review of all corneal tissues preserved by the Sorocaba Eye Bank from January to April of 2014 was performed...
April 2018: Arquivos Brasileiros de Oftalmologia
Nicolas Cesário Pereira, Adriana Dos Santos Forseto, Myrna Serapião Dos Santos, Gustavo Grottone, Albert Santos, José Álvaro Pereira Gomes
PURPOSE: We report a simplified Descemet's membrane endothelial keratoplasty (DMEK) technique that involves safe and effective preparation and introduction, correct orientation, and easy unfolding of the donor graft inside the recipient anterior chamber. METHODS: In this retrospective study, we assessed the surgical outcomes of 26 eyes of 23 consecutive patients (mean age, 61.2 ± 11.4 yr; range, 39-82 yr) with Fuchs endothelial corneal dystrophy (n=19) or bullous keratopathy (n=7) who underwent the Samba technique, a simplified DMEK method, at the Sorocaba Ophthalmology Hospital, Sorocaba Eye Bank, Sorocaba, Brazil, between August 2011 and July 2012...
April 2018: Arquivos Brasileiros de Oftalmologia
Shmuel Graffi, Pia Leon, Yoav Nahum, Shay Gutfreund, Rossella Spena, Leila Mattioli, Massimo Busin
AIM: To evaluate the outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) performed in eyes after failure of primary Descemet membrane endothelial keratoplasty (DMEK). METHODS: This was a retrospective, non-comparative interventional case series done in a tertiary care hospital. The study group included 21 eyes of patients which underwent UT-DSAEK following the failure of primary DMEK. Outcome measures included best spectacle-corrected visual acuity (BSCVA) and endothelial cell density (ECD) both recorded 6 and 12 months postoperatively as well as central graft thickness (CGT) measured 6 months after UT-DSAEK...
May 29, 2018: British Journal of Ophthalmology
Manuel Ramírez, Claudia Ortiz, Guillermo Dewit-Carter, Everardo Hernández-Quintela
Objective: To evaluate early in vivo corneal wound healing findings after Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) by using in vivo confocal microscopy. Method: A total of 15 eyes of 15 patients were included. In vivo confocal microscopy (Confoscan 4, Fortune Technologies, Italy) was performed from 4 to 7 weeks after DSAEK. Measurements were scanned from the corneal endothelium to the corneal surface with a Navis® software (NIDEK, Multi-Instrument Diagnostic System, Japan)...
2018: Cirugia y Cirujanos
Priya Narang, Keiki Mehta, Amar Agarwal
Placement of an anterior chamber iris implant for cosmetic reasons has been associated with development of various complications. Even after the implant has been explanted from the eye, it leaves a trail of after effects that necessitate surgical management. We describe a technique that comprises of performing phacoemulsification with single-pass four-throw pupilloplasty and a pre-Descemet's endothelial keratoplasty procedure for this eye with cosmetic iris implant complication.
June 2018: Indian Journal of Ophthalmology
Andrew M J Turnbull, Abdo Karim Tourkmani, Ramez Barbara, Parwez N Hossain, David F Anderson, Aris Konstantopoulos
No abstract text is available yet for this article.
May 16, 2018: Cornea
Hamish D McKee, Vishal Jhanji
PURPOSE: To describe a technique of using a femtosecond laser to assist with graft preparation for Descemet membrane endothelial keratoplasty (DMEK). METHODS: A femtosecond laser was used to assist in graft preparation for 3 DMEK procedures. The donor cornea is mounted on a proprietary artificial anterior chamber. A partial thickness deep circular cut is made with the femtosecond laser through the endothelium, Descemet membrane, and posterior stroma. Graft preparation is then completed without the use of a corneal trephine...
May 16, 2018: Cornea
Elizabeth McElnea, Billy Power, Conor Murphy
PURPOSE: To examine the management and associated outcomes of reported cases of interface fungal infection after Descemet stripping automated endothelial keratoplasty (EK). METHODS: A literature review identified reports of interface fungal infection after Descemet stripping automated EK. Data retrieved from the same included patient demographics, surgical procedure undertaken, donor rim culture result, clinical course, and outcome. A review of the relevant literature was also conducted...
May 16, 2018: Cornea
David Mingo-Botín, Francisco Arnalich-Montiel, Ana Couceiro de Juan, Sara Ortiz-Toquero
PURPOSE: To assess intrasession repeatability and intersession reproducibility of Pentacam corneal thickness maps in patients with Fuchs endothelial corneal dystrophy (FECD) before and after endothelial transplantation. METHODS: In this observational diagnostic evaluation, 20 healthy subjects along with 81 consecutive patients were examined. Patients were classified into 4 groups: FECD without corneal edema, FECD with corneal edema, Descemet stripping automated endothelial keratoplasty, and Descemet membrane endothelial keratoplasty...
May 16, 2018: Cornea
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