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https://www.readbyqxmd.com/read/27874938/rank-rankl-opg-pathway-genetic-association-with-history-of-ischemic-stroke-in-italian-population
#1
F Biscetti, S Giovannini, G Straface, F Bertucci, F Angelini, C Porreca, R Landolfi, A Flex
OBJECTIVE: RANKL is a member of the TNF superfamily that stimulates chemokine release, monocyte/macrophage matrix migration and matrix metalloproteinase activity and plays an important role in atherosclerosis. In our study, we have evaluated whether RANKL gene polymorphisms are involved in ischemic stroke in Italian subjects. PATIENTS AND METHODS: In a retrospective study we have included 487 patients (242 males, 245 females) with history of ischemic stroke and 543 control subjects without history of ischemic stroke (277 males, 276 females)...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27014153/attachment-representations-and-early-interactions-in-drug-addicted-mothers-a-case-study-of-four-women-with-distinct-adult-attachment-interview-classifications
#2
Alessio Porreca, Francesca De Palo, Alessandra Simonelli, Nicoletta Capra
Drug addiction is considered a major risk factor that can influence maternal functioning at multiple levels, leading to less optimal parental qualities and less positive interactive exchanges in mother-child dyads. Moreover, drug abusers often report negative or traumatic attachment representations regarding their own childhood. These representations might affect, to some extent, later relational and developmental outcomes of their children. This study explored whether the development of dyadic interactions in addicted women differed based on attachment status...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/26512966/evaluation-of-low-doses-bpa-induced-perturbation-of-glycemia-by-toxicogenomics-points-to-a-primary-role-of-pancreatic-islets-and-to-the-mechanism-of-toxicity
#3
E Carchia, I Porreca, P J Almeida, F D'Angelo, D Cuomo, M Ceccarelli, M De Felice, M Mallardo, C Ambrosino
Epidemiologic and experimental studies have associated changes of blood glucose homeostasis to Bisphenol A (BPA) exposure. We took a toxicogenomic approach to investigate the mechanisms of low-dose (1 × 10(-9 )M) BPA toxicity in ex vivo cultures of primary murine pancreatic islets and hepatocytes. Twenty-nine inhibited genes were identified in islets and none in exposed hepatocytes. Although their expression was slightly altered, their impaired cellular level, as a whole, resulted in specific phenotypic changes...
2015: Cell Death & Disease
https://www.readbyqxmd.com/read/26465170/discovery-of-novel-multifunctional-ligands-with-%C3%AE-%C3%AE-opioid-agonist-neurokinin-1-nk1-antagonist-activities-for-the-treatment-of-pain
#4
Aswini Kumar Giri, Christopher R Apostol, Yue Wang, Brittany L Forte, Tally M Largent-Milnes, Peg Davis, David Rankin, Gabriella Molnar, Keith M Olson, Frank Porreca, Todd W Vanderah, Victor J Hruby
Multifunctional ligands with agonist bioactivities at μ/δ opioid receptors (MOR/DOR) and antagonist bioactivity at the neurokinin-1 receptor (NK1R) have been designed and synthesized. These peptide-based ligands are anticipated to produce better biological profiles (e.g., higher analgesic effect with significantly less adverse side effects) compared to those of existing drugs and to deliver better synergistic effects than coadministration of a mixture of multiple drugs. A systematic structure-activity relationship (SAR) study has been conducted to find multifunctional ligands with desired activities at three receptors...
November 12, 2015: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26055663/the-biopsy-gleason-score-3-4-in-a-single-core-does-not-necessarily-reflect-an-unfavourable-pathological-disease-after-radical-prostatectomy-in-comparison-with-biopsy-gleason-score-3-3-looking-for-larger-selection-criteria-for-active-surveillance-candidates
#5
R Schiavina, M Borghesi, E Brunocilla, D Romagnoli, D Diazzi, F Giunchi, V Vagnoni, C V Pultrone, H Dababneh, A Porreca, M Fiorentino, G Martorana
BACKGROUND: To assess whether the addition of clinical Gleason score (Gs) 3+4 to the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria affects pathologic results in patients who are potentially suitable for active surveillance (AS) and to identify possible clinical predictors of unfavourable outcome. METHODS: Three hundred and twenty-nine men who underwent radical prostatectomy with complete clinical and follow-up data and who would have fulfilled the inclusion criteria of the PRIAS protocol at the time of biopsy except for the addition of biopsy Gs=3+4 and with at least 10 cores taken have been evaluated...
September 2015: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/25948806/state-of-the-art-of-pet-ct-with-11-choline-and-18f-fluorocholine-in-the-diagnosis-and-follow-up-of-localized-and-locally-advanced-prostate-cancer
#6
REVIEW
Valerio Vagnoni, Eugenio Brunocilla, Lorenzo Bianchi, Angelo Porreca, Marco Borghesi, Cristian Vincenzo Pultrone, Porreca Angelo, Francesco Chessa, Francesco Ceci, Francesco Mengoni, Hussam Dababneh, Paolo Castellucci, Stefano Fanti, Giuseppe Martorana, Riccardo Schiavina
OBJECTIVE: To provide an updated state of the art about the role of positron emission tomography/computed tomography (PET/CT) with 11C-Choline and 18F-fluorocholine in the localized and locally advanced Prostate Cancer (PCa) in the staging and restaging setting. METHODS: We performed a non-systematic review of the literature based on a free-text search in the National Library of Medicine Database (MEDLINE) to select English-language published papers evaluating PET and PET/CT imaging with radiolabelled choline in initial diagnosis and in post-treatment phase in PCa patients...
April 2015: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/25692657/biocompatible-pedot-nafion-composite-electrode-coatings-for-selective-detection-of-neurotransmitters-in-vivo
#7
Richard F Vreeland, Christopher W Atcherley, Wilfred S Russell, Jennifer Y Xie, Dong Lu, Nicholas D Laude, Frank Porreca, Michael L Heien
A Nafion and poly(3,4-ethylenedioxythiophene) (PEDOT) containing composite polymer has been electropolymerized on carbon-fiber microelectrodes with the goal of creating a mechanically stable, robust, and controllable electrode coating that increases the selectivity and sensitivity of in vivo electrochemical measurements. The coating is deposited on carbon-fiber microelectrodes by applying a triangle waveform from +1.5 V to -0.8 V and back in a dilute solution of ethylenedioxythiophene (EDOT) and Nafion in acetonitrile...
March 3, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/24581634/the-acttion-american-pain-society-pain-taxonomy-aapt-an-evidence-based-and-multidimensional-approach-to-classifying-chronic-pain-conditions
#8
Roger B Fillingim, Stephen Bruehl, Robert H Dworkin, Samuel F Dworkin, John D Loeser, Dennis C Turk, Eva Widerstrom-Noga, Lesley Arnold, Robert Bennett, Robert R Edwards, Roy Freeman, Jennifer Gewandter, Sharon Hertz, Marc Hochberg, Elliot Krane, Patrick W Mantyh, John Markman, Tuhina Neogi, Richard Ohrbach, Judith A Paice, Frank Porreca, Bob A Rappaport, Shannon M Smith, Thomas J Smith, Mark D Sullivan, G Nicholas Verne, Ajay D Wasan, Ursula Wesselmann
UNLABELLED: Current approaches to classification of chronic pain conditions suffer from the absence of a systematically implemented and evidence-based taxonomy. Moreover, existing diagnostic approaches typically fail to incorporate available knowledge regarding the biopsychosocial mechanisms contributing to pain conditions. To address these gaps, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the U...
March 2014: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/24108410/limited-central-side-effects-of-a-%C3%AE-subunit-subtype-selective-gabaa-receptor-allosteric-modulator
#9
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Timothy B Johnstone, Jennifer Y Xie, Frank Porreca, Kelvin W Gee
GABAergic anxiolytics have well-documented centrally mediated side effects including sedation, potentiation of ethanol, tolerance, abuse liability and memory impairment. Most research directed towards identifying an anxioselective GABAergic therapeutic has been based upon the theory that these side effects could be mitigated by avoiding α1/5-subunit GABAA receptors while specifically targeting those with the α2/3-subunit. Unfortunately, there are prominent exceptions to this theory and it has yet to be translated into clinical success...
May 2014: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/23860305/building-a-better-analgesic-multifunctional-compounds-that-address-injury-induced-pathology-to-enhance-analgesic-efficacy-while-eliminating-unwanted-side-effects
#10
T M Largent-Milnes, S W Brookshire, D P Skinner, K E Hanlon, D Giuvelis, T Yamamoto, P Davis, C R Campos, P Nair, S Deekonda, E J Bilsky, F Porreca, V J Hruby, T W Vanderah
The most highly abused prescription drugs are opioids used for the treatment of pain. Physician-reported drug-seeking behavior has resulted in a significant health concern among doctors trying to adequately treat pain while limiting the misuse or diversion of pain medications. In addition to abuse liability, opioid use is associated with unwanted side effects that complicate pain management, including opioid-induced emesis and constipation. This has resulted in restricting long-term doses of opioids and inadequate treatment of both acute and chronic debilitating pain, demonstrating a compelling need for novel analgesics...
October 2013: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/23785130/analogous-responses-in-the-nucleus-accumbens-and-cingulate-cortex-to-pain-onset-aversion-and-offset-relief-in-rats-and-humans
#11
COMPARATIVE STUDY
L Becerra, E Navratilova, F Porreca, D Borsook
In humans, functional magnetic resonance imaging (fMRI) activity in the anterior cingulate cortex (ACC) and the nucleus accumbens (NAc) appears to reflect affective and motivational aspects of pain. The responses of this reward-aversion circuit to relief of pain, however, have not been investigated in detail. Moreover, it is not clear whether brain processing of the affective qualities of pain in animals parallels the mechanisms observed in humans. In the present study, we analyzed fMRI blood oxygen level-dependent (BOLD) activity separately in response to an onset (aversion) and offset (reward) of a noxious heat stimulus to a dorsal part of a limb in both humans and rats...
September 2013: Journal of Neurophysiology
https://www.readbyqxmd.com/read/23765052/next-generation-carrier-screening
#12
Mark A Umbarger, Caleb J Kennedy, Patrick Saunders, Benjamin Breton, Niru Chennagiri, John Emhoff, Valerie Greger, Stephanie Hallam, David Maganzini, Cynthia Micale, Marcia M Nizzari, Charles F Towne, George M Church, Gregory J Porreca
PURPOSE: Carrier screening for recessive Mendelian disorders traditionally employs focused genotyping to interrogate limited sets of mutations most prevalent in specific ethnic groups. We sought to develop a next-generation DNA sequencing-based workflow to enable analysis of a more comprehensive set of disease-causing mutations. METHODS: We utilized molecular inversion probes to capture the protein-coding regions of 15 genes from genomic DNA isolated from whole blood and sequenced those regions using the Illumina HiSeq 2000 (Illumina, San Diego, CA)...
February 2014: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/23034269/inhibition-of-p-glycoprotein-mediated-transport-by-s-adenosylmethionine-and-cynarin-in-multidrug-resistant-human-uterine-sarcoma-mes-sa-dx5-cells
#13
A Angelini, R Di Pietro, L Centurione, M L Castellani, P Conti, E Porreca, F Cuccurullo
Multidrug resistance (MDR) to anticancer chemotherapy is often mediated by the overexpression of the plasma membrane drug transporter P-glycoprotein (Pgp) encoded by multidrug resistance gene (MDR1). Various chemosensitizing agents are able to inhibit Pgp activity but their clinical application is limited by their toxicity. Furthermore, hepatotoxicity related to chemotherapy causes delays of treatment in cancer patients and often requires supplementation of anti-tumour therapy with hepatoprotective agents. In this in vitro study, we investigated the effectiveness of an endogenous hepatoprotective agent, S-adenosylmethionine (SAMe), and a natural hepatoprotective compound, Cynarin (Cyn), to inhibit Pgp activity in order to evaluate their potential use as chemosensitizing agents...
July 2012: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/22840695/discovery-of-a-potent-orally-bioavailable-and-highly-selective-human-neuronal-nitric-oxide-synthase-nnos-inhibitor-n-1-piperidin-4-yl-indolin-5-yl-thiophene-2-carboximidamide-as-a-pre-clinical-development-candidate-for-the-treatment-of-migraine
#14
Subhash C Annedi, Shawn P Maddaford, Jailall Ramnauth, Paul Renton, Taras Rybak, Sarah Silverman, Suman Rakhit, Gabriela Mladenova, Peter Dove, John S Andrews, Dongqin Zhang, Frank Porreca
We recently reported a series of 1,6-disubstituted indoline-based thiophene amidine compounds (5) as selective neuronal nitric oxide synthase (nNOS) inhibitors to mitigate the cardiovascular liabilities associated with hERG K(+) channel inhibition (IC(50) = 4.7 μM) with previously reported tetrahydroquinoline-based selective nNOS inhibitors (4). The extended structure-activity relationship studies within the indoline core led to the identification of 43 as a selection candidate for further evaluations. The in vivo activity in two different pain (spinal nerve ligation and migraine pain) models, the excellent physicochemical and pharmacokinetic properties, oral bioavailability (F(po) = 91%), and the in vitro safety profile disclosed in this report make 43 an ideal candidate for further evaluation in clinical applications related to migraine pain...
September 2012: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/22122547/pharmacological-activity-of-a-bv8-analogue-modified-in-position-24
#15
R Lattanzi, P Sacerdote, S Franchi, M Canestrelli, R Miele, D Barra, S Visentin, C DeNuccio, F Porreca, M De Felice, F Guida, L Luongo, V de Novellis, S Maione, L Negri
BACKGROUND AND PURPOSE: The amphibian peptide Bv8 induces potent nociceptive sensitization in rodents. Its mammalian homologue, prokineticin 2 (PROK2), is strongly up-regulated in inflamed tissues and is a major determinant in triggering inflammatory pain. Bv8 and PROK2 activate two closely related GPCRs, PK(1) and PK(2) , in a relatively non-selective fashion. To characterize better the roles of the two receptors in hyperalgesia and to obtain ligands whose binding affinity and efficacy differed for the two receptors, we modified the Bv8 molecule in regions essential for receptor recognition and activation...
June 2012: British Journal of Pharmacology
https://www.readbyqxmd.com/read/21987056/overview-of-dna-sequencing-strategies
#16
Jay A Shendure, Gregory J Porreca, George M Church, Andrew F Gardner, Cynthia L Hendrickson, Jan Kieleczawa, Barton E Slatko
Efficient and cost-effective DNA sequencing technologies are critical to the progress of molecular biology. This overview of DNA sequencing strategies provides a high-level review of seven distinct approaches to DNA sequencing: (a) dideoxy sequencing; (b) solid phase sequencing; (c) sequencing-by-hybridization; (d) mass spectrometry; (e) cyclic array sequencing; (f) microelectrophoresis; and (g) nanopore sequencing. Other platforms currently in development are also briefly described. The primary focus here is on Sanger dideoxy sequencing, which has been the dominant technology since 1977, and on cyclic array strategies, for which several competitive implementations have been developed since 2005...
October 2011: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/21880209/the-effect-of-the-plasticizer-diethylhexyl-phthalate-on-transport-activity-and-expression-of-p-glycoprotein-in-parental-and-doxo-resistant-human-sarcoma-cell-lines
#17
A Angelini, L Centurione, S Sancilio, M L Castellani, P Conti, C Di Ilio, E Porreca, F Cuccurullo, R Di Pietro
Multidrug resistance (MDR) to cancer therapy is frequently associated with the over-expression of the multidrug transporter MDR1 gene product P-glycoprotein (Pgp) in several types of human tumours. Various chemosensitizers have been used to inhibit Pgp activity but toxicity limits their clinical application. Di(2-ethylhexyl)phthalate (DEHP) is a plasticizer that is released from polyvinyl chloride (PVC) medical devices. Therefore, cancer patients undertaking chemotherapy are exposed to a clinically important amount of DEHP through blood and blood component transfusions, apheresis products, intravenous chemotherapy, parenteral nutrition and other medical treatments...
April 2011: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/21563471/-health-status-and-life-style-in-castel-malnome-rome-i-ii-cent-a-d
#18
P Catalano, V Benassi, C Caldarini, L Cianfriglia, R Mosticone, A Nava, W Pantano, F Porreca
The necropolis of Castel Malnome, chronologically framed between the I and II century AD, is located in the vicinity of Ponte Galeria (Rome), nearby the via Portuense. The excavation of the funerary site has allowed the collection of 292 inhumations, referred to the lower social classes and for the most part adult males. Regarding the funerary ritual, only the 42.8% of the graves had a tiles cover, while about one third provided grave goods. The field analysis shows that almost all the burials are primaries, and is not possible to highlight a main position of the inhumated individuals...
2010: Medicina Nei Secoli
https://www.readbyqxmd.com/read/20977451/spinal-or-systemic-ty005-a-peptidic-opioid-agonist-neurokinin-1-antagonist-attenuates-pain-with-reduced-tolerance
#19
T M Largent-Milnes, T Yamamoto, P Nair, J W Moulton, V J Hruby, J Lai, F Porreca, T W Vanderah
BACKGROUND AND PURPOSE: The use of opioids in treating pain is limited due to significant side effects including somnolence, constipation, analgesic tolerance, addiction and respiratory depression. Pre-clinical studies have shown that neurokinin 1 (NK(1) ) receptor antagonists block opioid-induced antinociceptive tolerance and may inhibit opioid-induced rewarding behaviours. Here, we have characterized a bifunctional peptide with both opioid agonist and NK(1) antagonist pharmacophores in a rodent model of neuropathic pain...
November 2010: British Journal of Pharmacology
https://www.readbyqxmd.com/read/20537331/bone-morphogenetic-protein-2-may-represent-the-molecular-link-between-oxidative-stress-and-vascular-stiffness-in-chronic-kidney-disease
#20
G Dalfino, S Simone, S Porreca, C Cosola, C Balestra, C Manno, F P Schena, G Grandaliano, G Pertosa
Oxidative stress and vascular calcifications are emergent risk factors for the accelerated atherosclerosis process featuring chronic kidney disease (CKD). Vascular calcification is an active process similar to bone modelling, where BMP-2 may play a pathogenic role. Aim of our study was to investigate the link between oxidative stress, BMP-2 protein expression and vascular disease in CKD. We enrolled 85 CKD patients (K-DOQI stage II or higher) and 41 healthy individuals. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG) was used as a marker of oxidative stress...
August 2010: Atherosclerosis
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