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https://www.readbyqxmd.com/read/28646182/high-intensity-interval-training-improves-mitochondrial-function-and-suppresses-thrombin-generation-in-platelets-undergoing-hypoxic-stress
#1
Li-Hua Wu, Shao-Chiang Chang, Tieh-Cheng Fu, Ching-Hui Huang, Jong-Shyan Wang
This study elucidates how high-intensity interval training (HIT) and moderate-intensity continuous training (MCT) affect mitochondrial functionality and thrombin generation (TG) in platelets following hypoxic exercise (HE, 100 W under 12% O2 for 30 min). Forty-five healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max, n = 15) or MCT (sustained 60%VO2max, n = 15) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group (CTL, n = 15) that did not received exercise intervention...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28644335/practice-bulletin-number-179-breast-cancer-risk-assessment-and-screening-in-average-risk-women
#2
(no author information available yet)
Breast cancer is the most commonly diagnosed cancer in women in the United States and the second leading cause of cancer death in American women (1). Regular screening mammography starting at age 40 years reduces breast cancer mortality in average-risk women (2). Screening, however, also exposes women to harm through false-positive test results and overdiagnosis of biologically indolent lesions. Differences in balancing benefits and harms have led to differences among major guidelines about what age to start, what age to stop, and how frequently to recommend mammography screening in average-risk women (2-4)...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28644328/practice-bulletin-no-179-summary-breast-cancer-risk-assessment-and-screening-in-average-risk-women
#3
(no author information available yet)
Breast cancer is the most commonly diagnosed cancer in women in the United States and the second leading cause of cancer death in American women (1). Regular screening mammography starting at age 40 years reduces breast cancer mortality in average-risk women (2). Screening, however, also exposes women to harm through false-positive test results and overdiagnosis of biologically indolent lesions. Differences in balancing benefits and harms have led to differences among major guidelines about what age to start, what age to stop, and how frequently to recommend mammography screening in average-risk women (2-4)...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28643209/high-intensity-interval-training-interventions-in-children-and-adolescents-a-systematic-review
#4
REVIEW
William T B Eddolls, Melitta A McNarry, Gareth Stratton, Charles O N Winn, Kelly A Mackintosh
BACKGROUND: Whilst there is increasing interest in the efficacy of high-intensity interval training in children and adolescents as a time-effective method of eliciting health benefits, there remains little consensus within the literature regarding the most effective means for delivering a high-intensity interval training intervention. Given the global health issues surrounding childhood obesity and associated health implications, the identification of effective intervention strategies is imperative...
June 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28641703/a-randomised-controlled-trial-to-assess-the-cost-effectiveness-of-intensive-versus-no-scheduled-follow-up-in-patients-who-have-undergone-resection-for-colorectal-cancer-with-curative-intent
#5
David Mant, Alastair Gray, Siân Pugh, Helen Campbell, Stephen George, Alice Fuller, Bethany Shinkins, Andrea Corkhill, Jane Mellor, Elizabeth Dixon, Louisa Little, Rafael Perera-Salazar, John Primrose
BACKGROUND: Intensive follow-up after surgery for colorectal cancer is common practice but lacks a firm evidence base. OBJECTIVE: To assess whether or not augmenting symptomatic follow-up in primary care with two intensive methods of follow-up [monitoring of blood carcinoembryonic antigen (CEA) levels and scheduled imaging] is effective and cost-effective in detecting the recurrence of colorectal cancer treatable surgically with curative intent. DESIGN: Randomised controlled open-label trial...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28639441/effect-of-periodized-high-intensity-interval-training-hiit-on-body-composition-and-attitudes-towards-hunger-in-active-men-and-women
#6
Todd A Astorino, Brendyn Heath, Jason Bandong, Gina M Ordille, Ramon Contreras, Matthew Montell, Matthew M Schubert
BACKGROUND: High intensity interval training (HIIT) increases maximal oxygen uptake similar to aerobic exercise. However, changes in body composition are equivocal in response to HIIT. AIM: We examined changes in body composition and dietary restraint in response to 20 sessions of HIIT varying in structure. METHODS: Thirty nine active men and women (age and VO2max = 22.5 ± 4.4 yr and 40.1 ± 5.6 mL/kg/min) were randomized to one of three periodized HIIT regimes performed on a cycle ergometer...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28638983/treatment-of-benign-thyroid-nodules-by-high-intensity-focused-ultrasound-hifu-at-different-acoustic-powers-a-study-on-in-silico-phantom
#7
Fabiano Bini, Pierpaolo Trimboli, Franco Marinozzi, Luca Giovanella
BACKGROUND: The non-surgical therapies of benign thyroid nodules are gaining momentum due to the possibility to reduce the nodule's volume and avoid surgery. As the last technique introduced, high intensity focused ultrasound allows the thermal tissue treatment by directing energy inside the targeted nodule with no invasive instruments. In the present study we applied the Food and Drug Administration high intensity focused ultrasound simulator to in-silico phantom to evaluate the effects obtained by different acoustic powers...
June 21, 2017: Endocrine
https://www.readbyqxmd.com/read/28638269/clinical-insomnia-and-associated-factors-in-failed-back-surgery-syndrome-a-retrospective-cross-sectional-study
#8
Soon Young Yun, Do Heon Kim, Hae Yoon Do, Shin Hyung Kim
Background Insomnia frequently occurs to patients with persistent back pain. By worsening pain, mood, and physical functioning, insomnia could lead to the negative clinical consequences of patients with failed back surgery syndrome (FBSS). This retrospective and cross-sectional study aims to identify the risk factors associated with clinical insomnia in FBSS patients. Methods A total of 194 patients with FBSS, who met the study inclusion criteria, were included in this analysis. The Insomnia Severity Index (ISI) was utilized to ascertain the presence of clinical insomnia (ISI score ≥ 15)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28637852/testing-the-molecular-clock-using-mechanistic-models-of-fossil-preservation-and-molecular-evolution
#9
Rachel C M Warnock, Ziheng Yang, Philip C J Donoghue
Molecular sequence data provide information about relative times only, and fossil-based age constraints are the ultimate source of information about absolute times in molecular clock dating analyses. Thus, fossil calibrations are critical to molecular clock dating, but competing methods are difficult to evaluate empirically because the true evolutionary time scale is never known. Here, we combine mechanistic models of fossil preservation and sequence evolution in simulations to evaluate different approaches to constructing fossil calibrations and their impact on Bayesian molecular clock dating, and the relative impact of fossil versus molecular sampling...
June 28, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28635179/changing-trends-in-opioid-use-among-u-s-rheumatoid-arthritis-patients
#10
Jeffrey R Curtis, Fenglong Xie, Christian Smith, Kenneth G Saag, Lang Chen, Timothy Beukelman, Melissa Mannion, Huifeng Yun, Stefan Kertesz
Introduction Opioid prescribing recently has come under intense scrutiny. However, longitudinal patterns of opioid prescription receipt in a population-based cohort of patients who have chronic pain, such as those with rheumatoid arthritis (RA), have not been well characterized. Methods We identified a cohort of RA patients based on 2006-2014 Medicare data and evaluated longitudinal time trends in regular opioid use (>=3 filled prescriptions in each 12 month interval). A separate analysis in 2014 assessed rheumatologist-specific variability in regular opioid prescription for RA patients...
June 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28634135/outcomes-and-role-of-urgent-endoscopy-in-high-risk-patients-with-acute-nonvariceal-gastrointestinal-bleeding
#11
Soo-Han Cho, Yoon-Seon Lee, Youn-Jung Kim, Chang Hwan Sohn, Shin Ahn, Dong-Woo Seo, Won Young Kim, Jae Ho Lee, Kyoung Soo Lim
BACKGROUND & AIMS: We investigated clinical outcomes in high-risk patients with acute nonvariceal upper gastrointestinal bleeding (UGIB), and determined if urgent endoscopy is effective. METHODS: Consecutive patients with Glasgow-Blatchford score >7 who underwent endoscopy for acute nonvariceal UGIB at the emergency department from January 1, 2005, to December 31, 2014, were included. Urgent (<6 h) and elective (6-48 h) endoscopies were defined according to the time to endoscopy after the initial presentation...
June 17, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28634056/a-new-and-accurate-predictive-model-for-the-efficacy-of-extracorporeal-shock-wave-therapy-in-managing-patients-with-chronic-plantar-fasciitis
#12
Mengchen Yin, Ni Chen, Quan Huang, Anastasia Sulindro Marla, Junming Ma, Jie Ye, Wen Mo
OBJECTIVES: To identify factors for the outcome of a minimum clinically successful therapy and to establish a predictive model of extracorporeal shock wave therapy (ESWT) in managing patients with chronic plantar fasciitis. DESIGN: Randomized controlled, prospective study. SETTING: Outpatient of local medical center settings. PARTICIPANTS: Patients treated for symptomatic chronic plantar fasciitis between 2014 and 2016 (N=278)...
June 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28633487/high-intensity-interval-training-hiit-improves-physical-performance-and-frailty-in-aged-mice
#13
Kenneth Ladd Seldeen, Ginger Lasky, Merced Maria Leiker, Manhui Pang, Kirkwood Ely Personius, Bruce Robert Troen
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks...
June 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28633001/impact-of-4-weeks-of-interval-training-on-resting-metabolic-rate-fitness-and-health-related-outcomes
#14
Matthew M Schubert, Holly E Clarke, Rebekah F Seay, Katie K Spain
PURPOSE: Resting metabolic rate (RMR) and substrate oxidation (RER) are important indicators of health. The effects of interval training on RMR have not been thoroughly investigated, which was the purpose of the present study. METHODS: Thirty men and women (mean ± SD age and VO2max: 28.8 ± 7.6 yrs and 33.0 ± 8.3 mL∙kg-1∙min-1) completed 4 weeks of Wingate-based sprint interval training (SIT), repeated 1-minute high-intensity intervals (HIIT), or served as controls (CON)...
June 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28630583/acute-modification-of-cardiac-autonomic-function-of-high-intensity-interval-training-in-collegiate-male-soccer-players-with-different-chronotype-a-cross-over-study
#15
Matteo Bonato, Luca Agnello, Letizia Galasso, Angela Montaruli, Eliana Roveda, Giampiero Merati, Antonio La Torre, Jacopo A Vitale
The purpose of this study was to evaluate if the time of the day (8.00 a.m. vs 8.00 p.m.) and chronotype could influence autonomic cardiac control in soccer players in relation to an acute session of high-intensity interval training. The morningness-eveningness questionnaire was administered to recruit Morning-type and Evening-type collegiate male soccer players. Therefore, 24 players (12 Morning-types and 12 Evening-types) were randomly assigned, to either morning (n = 12; age 23 ± 3 years; height 1.75 ± 0...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28630575/acute-and-post-exercise-physiological-responses-to-high-intensity-interval-training-in-endurance-and-sprint-athletes
#16
Lukas Cipryan, Gerhard Tschakert, Peter Hofmann
The purpose of the presented study was to compare acute and post-exercise differences in cardiorespiratory, metabolic, cardiac autonomic, inflammatory and muscle damage responses to high-intensity interval exercise (HIIT) between endurance and sprint athletes. The study group consisted of sixteen highly-trained males (age 22.1 ± 2.5 years) participating in endurance (n = 8) or sprint (n = 8) sporting events. All the participants underwent three exercise sessions: short HIIT (work interval duration 30s), long HIIT (3min) and constant load exercise (CE)...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28629540/kinetics-and-dose-dependency-of-intranasal-oxytocin-effects-on-amygdala-reactivity
#17
Franny B Spengler, Johannes Schultz, Dirk Scheele, Maximiliane Essel, Wolfgang Maier, Markus Heinrichs, René Hurlemann
BACKGROUND: Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates amygdala reactivity in both species. However, the translation of neuromodulatory OXT effects to novel treatment approaches is hampered by the absence of studies defining the most effective dose and dose-response latency for targeting the amygdala...
May 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28629440/incidence-management-and-outcome-of-women-requiring-massive-transfusion-after-childbirth-in-the-netherlands-secondary-analysis-of-a-nationwide-cohort-study-between-2004-and-2006
#18
Paul I Ramler, Thomas van den Akker, Dacia D C A Henriquez, Joost J Zwart, Jos van Roosmalen
BACKGROUND: Postpartum hemorrhage remains the leading cause of maternal morbidity and mortality worldwide. Few population-based studies have examined the epidemiology of massive transfusion for postpartum hemorrhage. The aim of this study was to determine the incidence, management, and outcomes of women with postpartum hemorrhage who required massive transfusion in the Netherlands between 2004 and 2006. METHODS: Data for all women from a gestational age of 20 weeks onwards who had postpartum hemorrhage requiring eight or more red blood cell concentrates were obtained from a nationwide population-based cohort study including all 98 hospitals with a maternity unit in the Netherlands...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28628064/exercise-training-reduces-intrathoracic-fat-regardless-of-defective-glucose-tolerance
#19
Sanna M Honkala, Kumail K Motiani, Jari-Joonas Eskelinen, Anna Savolainen, Virva Saunavaara, Kirsi A Virtanen, Eliisa Löyttyniemi, Jukka Kapanen, Juhani Knuuti, Kari K Kalliokoski, Jarna C Hannukainen
PURPOSE: Epicardial (EAT) and pericardial (PAT) fat masses and myocardial triglyceride content (MTC) are enlarged in obesity and insulin resistance. We studied whether the high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) similarly decrease ectopic fat in and around the heart and whether the decrease is similar in healthy subjects and subjects with defective glucose tolerance (DGT). METHODS: A total of 28 healthy men (body mass index = 20...
July 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28625397/quantitative-evaluation-of-heartbeat-interval-time-series-using-poincar%C3%A3-analysis-reveals-distinct-patterns-of-heart-rate-dynamics-during-cycles-of-vagus-nerve-stimulation-in-patients-with-heart-failure
#20
Imad Libbus, Bruce D Nearing, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Optimization of stimulation parameters is essential to maximizing therapeutic efficacy and minimizing side effects. METHODS: The ANTHEM-HF study enrolled patients with heart failure who received chronic autonomic regulation therapy (ART) with an implantable vagus nerve stimulation (VNS) system on either the right (n=30) or left side (n=29). Acute effects of continuously cycling VNS on R-R interval dynamics were evaluated using post hoc Poincaré analysis of ECG recordings collected during multiple titration sessions over an 8-12week period...
June 8, 2017: Journal of Electrocardiology
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