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https://www.readbyqxmd.com/read/28214160/laboratory-based-surveillance-of-hospital-acquired-respiratory-virus-infection-in-a-tertiary-care-hospital
#1
Hye-Suk Choi, Mi-Na Kim, Heungsup Sung, Jeong-Young Lee, Hee-Youn Park, Sun-Hee Kwak, Young-Ju Lim, Min-Jee Hong, Sun-Kyung Kim, So-Yeon Park, Hyeon-Jeong Kim, Kyu-Ri Kim, Hye-Ran Choi, Jae Sim Jeong, Sang-Ho Choi
Of 7,772 laboratory-confirmed cases of respiratory viral infection among hospitalized patients, 22.8% were categorized as having hospital-acquired infection. The overall incidence of hospital-acquired respiratory viral infection was 3.9 (95% confidence interval, 3.7-4.1) cases per 1,000 admitted patients. Rhinovirus was the most common virus (30.3%), followed by influenza virus (17.6%) and parainfluenza virus (15.6%).
February 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28196678/co-infection-by-lymphogranuloma-venereum-and-haemophilus-parainfluenzae-during-an-episode-of-proctitis
#2
Antonio Maria Caballero-Mateos, Mercedes López de Hierro-Ruiz, Mario Rodríguez-Domínguez, Juan Carlos Galán-Montemayor, José Gutiérrez-Fernández
No abstract text is available yet for this article.
February 10, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28183847/human-rhinovirus-detection-in-the-lower-respiratory-tract-of-hematopoietic-cell-transplant-recipients-association-with-mortality
#3
Sachiko Seo, Alpana Waghmare, Emily M Scott, Hu Xie, Jane M Kuypers, Robert C Hackman, Angela P Campbell, Su-Mi Choi, Wendy M Leisenring, Keith R Jerome, Janet A Englund, Michael Boeckh
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the lower respiratory tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in respiratory samples. As comparative cohorts, 273 recipients with lower respiratory tract infection caused by respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28179533/a-point-mutation-in-the-rna-binding-domain-of-human-parainfluenza-virus-type-2-nucleoprotein-elicits-an-abnormally-enhanced-polymerase-activity
#4
Yusuke Matsumoto, Keisuke Ohta, Daniel Kolakofsky, Machiko Nishio
The genome RNA of human parainfluenza virus type 2 (hPIV2) that acts as template for the polymerase complex is entirely encapsidated by the nucleoprotein (NP). Recently, the crystal structure of NP of PIV5, a virus closely related to hPIV2, was resolved in association with RNA. Ten amino acids that contact the bound RNA-binding were identified, and are strictly conserved between PIV5 and hPIV2 NP. Mutation of hPIV2 NP Q202 (that contacts a base rather than the RNA backbone) to some amino acids resulted in an over thirty-fold increase of polymerase activity as evidenced by a minireplicon assay, even though RNA-binding affinity was unaltered...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28176480/de-novo-thrombotic-microangiopathy-following-simultaneous-pancreas-and-kidney-transplantation-managed-with-eculizumab
#5
REVIEW
Lani Shochet, John Kanellis, Ian Simpson, Joseph Ta, William Mulley
Thrombotic microangiopathy (TMA) is a well-recognised complication following transplantation, often due to an underlying genetic predisposition, medications or rejection. The use of eculizumab in these settings has been previously described, but its role still remains to be clarified. A 45-year-old man, with a history of type 1 diabetes mellitus and subsequent end-stage kidney failure, presented for a simultaneous pancreas-kidney transplant. Immunologically, he was well matched with the donor, and he received standard induction immunosuppression including tacrolimus...
February 2017: Nephrology
https://www.readbyqxmd.com/read/28159156/antiviral-treatments
#6
REVIEW
Michael G Ison
Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract. The M2 inhibitors, amantadine and rimantadine, were historically effective for the prevention and treatment of influenza A but all circulating strains are currently resistant to these drugs...
March 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28159006/the-potential-influence-of-human-parainfluenza-viruses-detected-during-hospitalization-among-critically-ill-patients-in-kuwait-2013-2015
#7
Sahar Essa, Haya Al-Tawalah, Sarah AlShamali, Widad Al-Nakib
BACKGROUND: The four types of human parainfluenza viruses (PIV) are important causes of community-acquired pneumonia, particularly in children; however, limited information exists about the incidence of PIV in critically ill patients. The aim of this study is to describe the spectrum, incidence and clinical features of PIV-associated infections diagnosed during the hospital stay of patients admitted to pediatric intensive care unit (PICU) and intensive care unit (ICU) of 5 medical centers across Kuwait...
February 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/28144057/respiratory-viruses-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#8
Parvaiz A Koul, Hyder Mir, Shabir Akram, Varsha Potdar, Mandeep S Chadha
OBJECTIVE: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) cause significant morbidity, mortality, and an inexorable decline of lung function. Data from developed countries have shown viruses to be important causes of AECOPD, but data from developing countries like India are scant. We set out to determine the contribution of viruses in the causation of hospitalized patients with AECOPD. METHODS: Twin nasopharyngeal/oropharyngeal swabs collected from 233 patients admitted with an acute AECOPD and tested for respiratory viruses including respiratory syncytial virus A and B, parainfluenza were (PIV) 1, 2, 3, and 4, human metapneumovirus (hMPV) A and B, influenza A and B, enterovirus, corona NL65, OC43, and 229E viruses, adenovirus 2 and 4, rhinovirus, and bocavirus, by duplex real time reverse-transcription polymerase chain reaction (qRT-PCR) using CDC approved primers and probes...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28140644/serologic-survey-for-antibodies-against-three-genotypes-of-bovine-parainfluenza-3-virus-in-unvaccinated-ungulates-in-alabama
#9
Benjamin W Newcomer, John D Neill, Patricia K Galik, Kay P Riddell, Yijing Zhang, Thomas Passler, Binu T Velayudhan, Paul H Walz
OBJECTIVE To determine titers of serum antibodies against 3 genotypes of bovine parainfluenza 3 virus (BPI3V) in unvaccinated ungulates in Alabama. ANIMALS 62 cattle, goats, and New World camelids from 5 distinct herds and 21 captured white-tailed deer. PROCEDURES Serum samples were obtained from all animals for determination of anti-BPI3V antibody titers, which were measured by virus neutralization assays that used indicator (reference) viruses from each of the 3 BPI3V genotypes (BPI3V-A, BPI3V-B, and BPI3V-C)...
February 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28138777/first-complete-genome-sequence-of-parainfluenza-virus-5-isolated-from-lesser-panda
#10
Jun-Qiong Zhai, Shao-Lun Zhai, Tao Lin, Jian-Kui Liu, He-Xing Wang, Bing Li, He Zhang, Shu-Zhan Zou, Xia Zhou, Meng-Fan Wu, Wu Chen, Man-Lin Luo
Parainfluenza virus 5 (PIV5) is widespread in mammals and humans. Up to now, there is little information about PIV5 infection in lesser pandas. In this study, a PIV5 variant (named ZJQ-221) was isolated from a lesser panda with respiratory disease in Guangzhou zoo in Guangdong province, southern China. The full-length genome of ZJQ-221 was found to be 15,246 nucleotides and consisted of seven non-overlapping genes encoding eight proteins (i.e., NP, V, P, M, F, SH, HN and L). Sequence alignment and genetic analysis revealed that ZJQ-221 shared a close relationship with a PIV5 strain of canine-origin (1168-1) from South Korea...
January 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28132571/the-diagnosis-and-management-of-respiratory-viral-infections-in-cystic-fibrosis
#11
W G Flight, A M Jones
Introduction Respiratory viruses, such as those that cause influenza and the common cold, are a regular feature of life for the entire human population. Among people with CF, these viruses are associated with prolonged respiratory illness and show a clear association with pulmonary exacerbations which in turn are associated with lung function decline and risk of death. Human rhinovirus is the most commonly encountered respiratory viral pathogen in CF although adenovirus, bocavirus, coronavirus, influenza, parainfluenza, metapneumovirus and respiratory syncytial virus are all also responsible for infections in this population...
January 30, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28131642/viral-influenza-like-illnesses-dynamic-interrelationships-during-the-2015-2016-influenza-season-in-hospitalized-patients
#12
B A Cunha
In hospitalized children and adults, the temporal relationship of viruses causing influenza-like illnesses (ILIs) and influenza has not been well described. During the 2015-2016 influenza season at our hospital, the dynamic interrelationships between ILI viruses (human metapneumovirus, respiratory syncytial virus, human parainfluenza viruses 3 and 4, rhinoviruses/enteroviruses, and coronaviruses) and influenza A were characterized in 768 hospitalized children and adults.
December 23, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28129374/il-27-limits-type-2-immunopathology-following-parainfluenza-virus-infection
#13
Gaia Muallem, Sagie Wagage, Yan Sun, Jonathan H DeLong, Alex Valenzuela, David A Christian, Gretchen Harms Pritchard, Qun Fang, Elizabeth L Buza, Deepika Jain, M Merle Elloso, Carolina B López, Christopher A Hunter
Respiratory paramyxoviruses are important causes of morbidity and mortality, particularly of infants and the elderly. In humans, a T helper (Th)2-biased immune response to these infections is associated with increased disease severity; however, little is known about the endogenous regulators of these responses that may be manipulated to ameliorate pathology. IL-27, a cytokine that regulates Th2 responses, is produced in the lungs during parainfluenza infection, but its role in disease pathogenesis is unknown...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28120567/lower-respiratory-tract-diseases-caused-by-common-respiratory-viruses-among-stem-cell-transplantation-recipients-a-single-center-experience-in-korea
#14
Kyung Wook Hong, Su Mi Choi, Dong Gun Lee, Sung Yeon Cho, Hyo Jin Lee, Jae Ki Choi, Si Hyun Kim, Sun Hee Park, Jung Hyun Choi, Jin Hong Yoo, Jong Wook Lee
PURPOSE: To describe the incidence, clinical courses, and risk factors for mortality of lower respiratory tract diseases (LRDs) caused by common respiratory viruses (CRVs) in stem cell transplantation (SCT) recipients. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 1038 patients who received SCT between January 2007 and August 2011 at a single center in Korea. RESULTS: Seventy-one CRV-LRDs were identified in 67 (6...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28114162/impact-of-viral-respiratory-pathogens-on-outcomes-after-pediatric-cardiac-surgery
#15
Katie Moynihan, Andrew Barlow, Nelson Alphonso, Ben Anderson, Janelle Johnson, Clare Nourse, Sanmarié Schlebusch, Tom R Karl, Luregn J Schlapbach
OBJECTIVES: Viral respiratory infection is commonly considered a relative contraindication to elective cardiac surgery. We aimed to determine the frequency and outcomes of symptomatic viral respiratory infection in pediatric cardiac surgical patients. DESIGN: Retrospective cohort study of children undergoing cardiac surgery. Symptomatic children were tested using a multiplex Polymerase Chain Reaction (respiratory virus polymerase chain reaction) panel capturing nine respiratory viruses...
January 20, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28113063/5-hydroxytryptophan-a-major-product-of-tryptophan-degradation-is-essential-for-optimal-replication-of-human-parainfluenza-virus
#16
M A G Rabbani, Sailen Barik
Interferon (IFN) exerts its antiviral effect by inducing a large family of cellular genes, named interferon (IFN)-stimulated genes (ISGs). An intriguing member of this family is indoleamine 2,3-dioxygenase (IDO), which catalyzes the first and rate-limiting step of the main branch of tryptophan (Trp) degradation, the kynurenine pathway. We recently showed that IDO strongly inhibits human parainfluenza virus type 3 (PIV3), a significant respiratory pathogen. Here, we show that 5-hydoxytryptophan (5-HTP), the first product of an alternative branch of Trp degradation and a serotonin precursor, is essential to protect virus growth against IDO in cell culture...
January 20, 2017: Virology
https://www.readbyqxmd.com/read/28112331/-detection-of-parainfluenza-virus-in-immunocompromised-and-immunocompetent-patients-in-a-tertiary-hospital-in-sao-paulo-brazil
#17
Sheila N Parmezan, Clarice Camargo, Aripuanã Watanabe, Patricio Godoy-Martínez, Celso Granato, Nancy Bellei
Parainfluenza virus infections (PIV) were evaluated in patients with mild and severe infections through real time PCR. One thousand and sixty-seven samples were collected from subjects as follows: 233 adult renal transplanted outpatients, 129 children with congenital heart disease, 381 with adult hematopoietic stem cell patients and 324 hospitalized patients suspected of influenza A (H1N1) pdm09 infection. PIV was detected in 74 (6.9%) samples. VPI-3 was the most frequent (60.8%) and a higher risk was observed for older adults (p = 0...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28109201/genetic-analyses-of-the-fusion-protein-genes-in-human-parainfluenza-virus-types-1-and-3-among-patients-with-acute-respiratory-infections-in-eastern-japan-from-2011-to-2015
#18
Rika Tsutsui, Hiroyuki Tsukagoshi, Koo Nagasawa, Masaki Takahashi, Yuki Matsushima, Akihide Ryo, Makoto Kuroda, Hideki Takami, Hirokazu Kimura
PURPOSE: To genetically explorer the fusion protein gene (F) in human parainfluenza virus type 1 (HPIV1) and type 3 (HPIV3) strains, we analyzed them in the patients with acute respiratory infections (ARI) in Eastern Japan from 2011 to 2015. METHODOLOGY: We constructed phylogenetic trees based on the HPIV and HPIV3 F gene using the maximum likelihood method and conducted p-distance, and selective pressure analyses. We also predicted the linear epitopes of the protein in the prototype strains...
January 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28103180/fluoroquinolone-macrolide-and-ketolide-resistance-in-haemophilus-parainfluenzae-from-south-africa
#19
Regina Esinam Abotsi, Usha Govinden, Krishnee Moodley, Sabiha Essack
Fluoroquinolones and ketolides are among the drugs of choice for the treatment of Haemophilus parainfluenzae infections. There has been a report of an emerging fluoroquinolone and telithromycin resistance in H. parainfluenzae isolates from the private sector of KwaZulu-Natal Province of South Africa that necessitates molecular investigation. The aim of this study is to characterize these resistance delineating mutations in genes commonly associated with reduced susceptibility. Ten H. parainfluenzae isolates retrieved from the sputum of 10 patients with H...
January 19, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28102432/synthesis-of-human-parainfluenza-virus-4-nucleocapsid-like-particles-in-yeast-and-their-use-for-detection-of-virus-specific-antibodies-in-human-serum
#20
Aistė Bulavaitė, Rita Lasickienė, Paulius Lukas Tamošiūnas, Martynas Simanavičius, Kęstutis Sasnauskas, Aurelija Žvirblienė
The aim of this study was to produce human parainfluenza virus type 4 (HPIV4) nucleocapsid (N) protein in yeast Saccharomyces cerevisiae expression system, to explore its structural and antigenic properties and to evaluate its applicability in serology. The use of an optimized gene encoding HPIV4 N protein amino acid (aa) sequence GenBank AGU90031.1 allowed high yield of recombinant N protein forming nucleocapsid-like particles (NLPs) in yeast. A substitution L332D disrupted self-assembly of NLPs, confirming the role of this position in the N proteins of Paramyxovirinae...
January 19, 2017: Applied Microbiology and Biotechnology
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