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https://www.readbyqxmd.com/read/28531552/the-role-of-next-generation-sequencing-in-infection-prevention-in-human-parainfluenza-virus-3-infections-in-immunocompromised-patients
#1
Atul Kothari, Mary J Burgess, Juan Carlos Rico Crescencio, Joshua L Kennedy, Jesse L Denson, Kurt C Schwalm, Ashley N Stoner, John C Kincaid, Faith E Davies, Darrell L Dinwiddie
BACKGROUND: Respiratory viral infections are a significant problem in patients with hematologic malignancies. We report a cluster of HPIV 3 infections in our myeloma patients, and describe the utility of next generation sequencing (NGS) to identify transmission linkages which can assist in infection prevention. OBJECTIVES: To evaluate the utility of NGS to track respiratory viral infection outbreaks and delineate between community acquired and nosocomial infections in our cancer units...
May 12, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28500338/inflammatory-bacteriome-featuring-fusobacterium-nucleatum-and-pseudomonas-aeruginosa-identified-in-association-with-oral-squamous-cell-carcinoma
#2
Nezar Noor Al-Hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E Homeida, Tsute Chen, Ali Mohamed Idris, Newell W Johnson
Studies on the possible association between bacteria and oral squamous cell carcinoma (OSCC) remain inconclusive, largely due to methodological variations/limitations. The objective of this study was to characterize the species composition as well as functional potential of the bacteriome associated with OSCC. DNA obtained from 20 fresh OSCC biopsies (cases) and 20 deep-epithelium swabs (matched control subjects) was sequenced for the V1-V3 region using Illumina's 2 × 300 bp chemistry. High quality, non-chimeric merged reads were classified to species level using a prioritized BLASTN-algorithm...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494927/comparison-of-interferon-and-bovine-herpesvirus-1-specific-iga-levels-in-nasal-secretions-of-dairy-cattle-administered-an-intranasal-modified-live-viral-vaccine-prior-to-calving-or-on-the-day-of-calving
#3
Victor S Cortese, Amelia Woolums, David J Hurley, Roy Berghaus, John K Bernard, Thomas H Short
Thirty-two Holstein cows were allocated to receive intranasal vaccination with modified live bovine herpesvirus-1 (BHV-1), bovine respiratory syncytial virus (BRSV) and parainfluenza type 3 virus (PI3V) vaccine either two weeks prior to their projected calving date, or within 24h after calving. Nasal secretions were collected twice at a 12-h interval on the day prior to vaccination (day 0) and at 2, 4, 7, 10 and 14days post vaccination to measure interferon (IFN) alpha, IFN-beta, IFN-gamma, and BHV-1-specific IgA by ELISA...
May 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28491883/haemophilus-parainfluenzae-endocarditis-associated-with-maxillary-sinusitis-and-complicated-by-cerebral-emboli-in-a-young-man
#4
Anthony E Duzenli, John Dwyer, Jeanne Carey
HACEK endocarditis is often difficult to diagnose given the slow-growing characteristics of the organisms involved. Haemophilus parainfluenzae, one of the HACEK organisms, is an uncommon cause of endocarditis. We describe a case of a previously healthy young man with H parainfluenzae endocarditis that was associated with maxillary sinusitis and severe systemic complications, including septic cerebral emboli and mitral valve perforation. Previously reported cases have also described a predilection for younger people, cardiac valve pathology, and a high prevalence of stroke...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28472480/characterizing-the-cellular-immune-response-to-parainfluenza-virus-3
#5
Paibel I Aguayo-Hiraldo, Reuben J Arasaratnam, Ifigeneia Tzannou, Manik Kuvalekar, Premal Lulla, Swati Naik, Caridad A Martinez, Pedro A Piedra, Juan F Vera, Ann M Leen
Parainfluenza virus (PIV) 3 infections are a major cause of morbidity and mortality in immunocompromised individuals with no approved therapies. Our group has demonstrated the safety and efficacy of adoptively transferred virus-specific T cells for the prevention and treatment of a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus 6 and Epstein-Barr virus. However, this approach is restricted to well-characterized viruses with known immunogenic/protective T cell target antigens, precluding extension to PIV-3...
May 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28472318/parainfluenza-virus-3-specific-t-cells-opportunity-for-intervention
#6
Alpana Waghmare, Janet A Englund, Michael Boeckh
No abstract text is available yet for this article.
May 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28471975/thymic-stromal-lymphopoietin-il-33-and-periostin-in-hospitalized-infants-with-viral-bronchiolitis
#7
María Luz García-García, Cristina Calvo, Ana Moreira, José Antonio Cañas, Francisco Pozo, Beatriz Sastre, Sergio Quevedo, Inmaculada Casas, Victoria Del Pozo
Much attention has recently been focused on thymic stromal lymphopoietin (TSLP), IL-33, and periostin in allergic disease, but less is known about their role in viral bronchiolitis.The aim of the study was to investigate whether infants exhibit enhanced nasal airway secretion of TSLP, IL-33, and periostin during natural respiratory viral bronchiolitis compared to healthy controls.In total, 213 infants < 2 years of age, hospitalized with bronchiolitis from October/2013 to April/2016 were enrolled alongside 45 healthy infants...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28466381/tetherin-antagonism-by-v-proteins-is-a-common-trait-among-the-genus-rubulavirus
#8
Keisuke Ohta, Yusuke Matsumoto, Morihiro Ito, Machiko Nishio
Tetherin (BST-2/CD317/HM1.24) is an anti-viral factor that restricts the budding of several enveloped viruses. Most of these viruses have evolved to encode tetherin antagonists. Our previous study demonstrated that the growth of human parainfluenza virus type 2 (hPIV-2), a member of the genus Rubulavirus in the family Paramyxoviridae, was inhibited by tetherin, and its V protein decreases the amount of cell surface tetherin by the interaction. In the present study, we investigated whether tetherin inhibits the growth of other rubulaviruses including PIV-5, mumps virus (MuV), simian virus 41, and hPIV-4, and whether their V proteins act as tetherin antagonists...
May 2, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28466061/evidence-of-respiratory-syncytial-virus-and-parainfluenza-3-virus-in-mexican-sheep
#9
M J Contreras-Luna, L A Ramírez-Martínez, R E Sarmiento Silva, C Cruz Lazo, A Pérez Torres, J I Sánchez-Betancourt
This is a first report in Mexico of the presence of antibodies against respiratory syncytial virus (RSV) and parainfluenza-3 virus in Mexican sheep in different productive stages. We determine the association of serological positivity with age and production system, and obtain molecular evidence of infection by both virus. RSV prevalence in adult sheep was 47% (49/105) at the tropic and 64% (63/99) at the uplands. A significant difference in RSV seropositivity between animals from the tropic and the uplands was observed (P < 0...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28463659/genetic-analysis-of-human-parainfluenza-virus-type-3-obtained-in-croatia-2011-2015
#10
Tanja Košutić-Gulija, Anamarija Slovic, Sunčanica Ljubin-Sternak, Gordana Mlinarić-Galinović, Dubravko Forčić
PURPOSE: This study investigated the HPIV3 circulating strains in Croatia and whether the other parts of HPIV3 genome (F gene and HN 582 nucleotides fragment) could be equally suitable for genetic and phylogenetic analysis. METHODOLOGY: Clinical materials were collected in period 2011-2015 from children suffering from respiratory illnesses. In positive HPIV3 samples viral genome was partially amplified and sequenced for HN and F genes. Obtained sequences were analysed by phylogenetic analysis and genetic characterization was performed...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28459230/emerging-fluoroquinolone-and-ketolide-resistance-in-haemophilus-parainfluenzae-in-south-africa
#11
Regina Esinam Abotsi, Usha Govinden, Krishnee Moodley, Sabiha Yusuf Essack
No abstract text is available yet for this article.
April 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28457597/global-epidemiology-of-non-influenza-rna-respiratory-viruses-data-gaps-and-a-growing-need-for-surveillance
#12
REVIEW
Julian W Tang, Tommy T Lam, Hassan Zaraket, W Ian Lipkin, Steven J Drews, Todd F Hatchette, Jean-Michel Heraud, Marion P Koopmans
Together with influenza, the non-influenza RNA respiratory viruses (NIRVs), which include respiratory syncytial virus, parainfluenza viruses, coronavirus, rhinovirus, and human metapneumovirus, represent a considerable global health burden, as recognised by WHO's Battle against Respiratory Viruses initiative. By contrast with influenza viruses, little is known about the contemporaneous global diversity of these viruses, and the relevance of such for development of pharmaceutical interventions. Although far less advanced than for influenza, antiviral drugs and vaccines are in different stages of development for several of these viruses, but no interventions have been licensed...
April 27, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28455668/isolation-and-genomic-characterization-of-a-canine-parainfluenza-virus-type-5-strain-in-china
#13
Caihong Liu, Xiangdong Li, Jianpo Zhang, Linxia Yang, Fan Li, Junhua Deng, Feifei Tan, Ming Sun, Yuxiu Liu, Kegong Tian
A canine parainfluenza virus type 5 strain was isolated from a lung sample from a diseased dog. The genome sequene of this isolate, named HeN0718, was determined and compared tho those of other previously reported canine parainfluenza viruses. Unlike previously reported viruses, the HeN0718 strain contained several nucleotide mutations in the SH gene that led to a frame shift in the open reading frame. Phylogenetic analysis based on the complete virus genome and the P, F, and HN genes showed that HeN0718 was genetically closest to D277, a Korean strain that was isolated in 2008...
April 28, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28455649/human-parainfluenza-virus-type-2%C3%A2-v-protein-inhibits-induction-of-tetherin
#14
Keisuke Ohta, Yusuke Matsumoto, Natsuko Yumine, Machiko Nishio
Tetherin is an anti-viral factor that restricts viral budding through tethering virions to the cell surface. The human parainfluenza virus type 2 (hPIV-2) V protein decreases cell surface tetherin in HeLa cells, which constitutively express endogenous tetherin. However, the role of the hPIV-2 V protein in tetherin induction remains unclear. Here, we examined whether hPIV-2 infection itself induces tetherin in HEK293 cells that have no basal expression of tetherin. Unlike influenza A virus (IAV) infection, hPIV-2 infection induced neither tetherin mRNA nor protein expression...
April 28, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28451903/a-single-l288i-substitution-in-the-fusion-protein-of-bovine-parainfluenza-virus-type-3-enhances-virus-growth-in-semi-suitable-cell-lines
#15
Ryosuke Matsuura, Marina Takada, Takehiro Kokuho, Takamitsu Tsuboi, Ken-Ichiro Kameyama, Kaoru Takeuchi
The bovine parainfluenza virus type 3 BN-CE vaccine strain was obtained by serial passage of the BN-1 strain in chicken embryonic fibroblasts (CEF). We previously identified a substitution (L288I) in the fusion (F) protein between the two strains. To examine the effect of the substitution on CEF adaptation and attenuation, we generated a recombinant BN-1 strain with the L288I substitution in the F protein (F(L288I)-EGFP). F(L288I)-EGFP replicated more efficiently than a recombinant BN-1 strain (wt-EGFP) in semi-suitable cell lines, suggesting that the L288I substitution was established in the BN-1 strain during the process of adaptation in CEF...
April 27, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28424887/a-metagenomics-study-for-the-identification-of-respiratory-viruses-in-mixed-clinical-specimens-an-application-of-the-iterative-mapping-approach
#16
Yu-Nong Gong, Shu-Li Yang, Guang-Wu Chen, Yu-Wen Chen, Yhu-Chering Huang, Hsiao-Chen Ning, Kuo-Chien Tsao
Metagenomic approaches to detect viral genomes and variants in clinical samples have various challenges, including low viral titers and bacterial and human genome contamination. To address these limitations, we examined a next-generation sequencing (NGS) and iterative mapping approach for virus detection in clinical samples. We analyzed 40 clinical specimens from hospitalized children diagnosed with acute bronchiolitis, croup, or respiratory tract infections in which virus identification by viral culture or polymerase chain reaction (PCR) was unsuccessful...
April 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28418771/persistence-in-temporary-lung-niches-a-survival-strategy-of-lung-resident-memory-cd8-t-cells
#17
Shiki Takamura
Respiratory virus infections, such as those mediated by influenza virus, parainfluenza virus, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus (SARS-CoV), rhinovirus, and adenovirus, are responsible for substantial morbidity and mortality, especially in children and older adults. Furthermore, the potential emergence of highly pathogenic strains of influenza virus poses a significant public health threat. Thus, the development of vaccines capable of eliciting long-lasting protective immunity to those pathogens is a major public health priority...
April 18, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28416404/genomic-and-antigenic-characterization-of-bovine-parainfluenza-3-viruses-in-the-united-states-including-modified-live-virus-vaccine-mlv-strains-and-field-strains-from-cattle
#18
R W Fulton, J D Neill, J T Saliki, C Landis, L J Burge, M E Payton
This study investigated the genetic and antigenic characterization of parainfluenza-3 virus (PI3V) of cattle. Using molecular tests including real time PCR and viral genome sequencing, PI3V strains could be separated into PI3V types, including PI3V A, PI3V B, and PI3V C. Isolates from cattle with bovine respiratory disease clinical signs and commercial vaccines in the U.S. with MLV PI3V were typed using these molecular tests. All the MLV vaccine strains tested were PI3V A. In most cases PI3V field strains from calves receiving MLV vaccines were types heterologous to the vaccine type A...
April 14, 2017: Virus Research
https://www.readbyqxmd.com/read/28414992/airway-proteases-an-emerging-drug-target-for-influenza-and-other-respiratory-virus-infections
#19
REVIEW
Manon Laporte, Lieve Naesens
To enter into airway epithelial cells, influenza, parainfluenza- and coronaviruses rely on host cell proteases for activation of the viral protein involved in membrane fusion. One protease, transmembrane protease serine 2 (TMPRSS2) was recently proven to be crucial for hemagglutinin cleavage of some human influenza viruses. Since the catalytic sites of the diverse serine proteases linked to influenza, parainfluenza- and coronavirus activation are structurally similar, active site inhibitors of these airway proteases could have broad therapeutic applicability against multiple respiratory viruses...
April 14, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28414572/molecular-characterization-of-fluoroquinolone-resistant-haemophilus-parainfluenzae-clinical-isolates-in-spain
#20
Inmaculada López-Hernández, Jesús Machuca, Paula Díaz de Alba, Carolina Sarvisé, Frederic Gómez, José Manuel Rodríguez-Martínez, Alvaro Pascual
OBJECTIVE: The objective was to characterize a group of clinical isolates of fluoroquinolone-resistant Haemophilus parainfluenzae collected in Northern Spain (March-December 2014). METHODS: Twelve clinical isolates of H. parainfluenzae were studied by performing antimicrobial susceptibility testing and PCR amplification and nucleotide sequencing of the QRDR (quinolone resistance-determining region) of gyrA, parC, gyrB, and parE genes. Screening for plasmid-mediated quinolone resistance (PMQR) was also studied...
April 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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