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Asthma AND obesity

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https://www.readbyqxmd.com/read/29332017/insulin-resistance-and-lung-function-in-obese-asthmatic-pre-pubertal-children
#1
Paola Di Filippo, Alessandra Scaparrotta, Daniele Rapino, Tommaso de Giorgis, Marianna Immacolata Petrosino, Marina Attanasi, Sabrina Di Pillo, Francesco Chiarelli, Angelika Mohn
BACKGROUND: Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR). METHODS: Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob)...
January 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29324762/obesogenic-diets-alter-metabolism-in-mice
#2
Megan R Showalter, Eric B Nonnecke, A L Linderholm, Tomas Cajka, Michael R Sa, Bo Lönnerdal, Nicholas J Kenyon, Oliver Fiehn
Obesity and accompanying metabolic disease is negatively correlated with lung health yet the exact mechanisms by which obesity affects the lung are not well characterized. Since obesity is associated with lung diseases as chronic bronchitis and asthma, we designed a series of experiments to measure changes in lung metabolism in mice fed obesogenic diets. Mice were fed either control or high fat/sugar diet (45%kcal fat/17%kcal sucrose), or very high fat diet (60%kcal fat/7% sucrose) for 150 days. We performed untargeted metabolomics by GC-TOFMS and HILIC-QTOFMS and lipidomics by RPLC-QTOFMS to reveal global changes in lung metabolism resulting from obesity and diet composition...
2018: PloS One
https://www.readbyqxmd.com/read/29319160/macrophage-plasticity-polarization-and-function-in-health-and-disease
#3
REVIEW
Abbas Shapouri Moghaddam, Saeed Mohammadian, Hossein Vazini, Mahdi Taghadosi, Seyed-Alireza Esmaeili, Fatemeh Mardani, Bita Seifi, Asadollah Mohammadi, Jalil Tavakol Afshari, Amirhossein Sahebkar
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro-inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th1 cytokines such as IFN-γ, GM-CSF and produce pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-6, IL-12, IL-23 and TNF-α, and 2) Alternatively activated or M2 macrophages, which are anti-inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL-4 and IL-13 and produce anti-inflammatory cytokines such as IL-10 and TGF-β...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#4
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29306658/elevating-adipose-eosinophils-in-obese-mice-to-physiologically-normal-levels-does-not-rescue-metabolic-impairments
#5
W Reid Bolus, Kristin R Peterson, Merla J Hubler, Arion J Kennedy, Marnie L Gruen, Alyssa H Hasty
OBJECTIVE: Obesity is a metabolic disorder that has reached epidemic proportions worldwide and leads to increased risk for diabetes, cardiovascular disease, asthma, certain cancers, and various other diseases. Obesity and its comorbidities are associated with impaired adipose tissue (AT) function. In the last decade, eosinophils have been identified as regulators of proper AT function. Our study aimed to determine whether normalizing the number of AT eosinophils in obese mice, to those of lean healthy mice, would reduce obesity and/or improve metabolic fitness...
December 16, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29295509/endocrine-disrupting-chemicals-mediated-through-binding-androgen-receptor-are-associated-with-diabetes-mellitus
#6
REVIEW
Sugunadevi Sakkiah, Tony Wang, Wen Zou, Yuping Wang, Bohu Pan, Weida Tong, Huixiao Hong
Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer's disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies...
December 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29286850/out-of-one-many-moving-beyond-a-single-guideline-toward-personalized-asthma-care-for-obese-children
#7
Anne M Fitzpatrick
No abstract text is available yet for this article.
January 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29284021/temporal-trends-in-educational-inequalities-in-non-communicable-diseases-in-korea-2007-2015
#8
Gyu Ri Kim, Chung Mo Nam
BACKGROUND: Socioeconomic inequalities in non-communicable diseases are known to exist; however there is a paucity of research describing the secular trends in these inequalities. To this end, the current study aims to explore the recent time trends in social patterning of selected non-communicable diseases among Korean adults between 2007 and 2015. METHODS: Using data from the Korea National Health and Nutrition Examination Survey (KNHANES), temporal trends in socioeconomic inequalities in diabetes, arthritis, asthma and depressive symptoms were assessed across three time points...
2017: PloS One
https://www.readbyqxmd.com/read/29279059/systemic-inflammation-mediates-the-detrimental-effects-of-obesity-on-asthma-control
#9
Xin Zhang, Jing Zheng, Li Zhang, Ying Liu, Gai Ping Chen, Hong Ping Zhang, Lei Wang, De Ying Kang, Lisa G Wood, Gang Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included using The Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of ≥30 kg/m2, overweight was defined as BMI between 25 to 29...
January 2, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29277382/prevalence-of-chronic-comorbidities-in-chikungunya-a-systematic-review-and-meta-analysis
#10
Alaa Badawi, Seung Gwan Ryoo, Danitsa Vasileva, Sahar Yaghoubi
BACKGROUND: Epidemiologic evidence suggests that patients with chikungunya virus (CHIKV) infection may be at risk of severe disease complications when they also have comorbidities such as obesity, diabetes, cardiac diseases, and/or asthma. However, the prevalence of these co-existing medical conditions in severe CHIKV cases has not been systematically reported. OBJECTIVE: The aim of the present study is to conduct a systematic review and meta-analysis to describe the prevalence of chronic comorbidities in CHIKV and evaluate their possible contributions to disease severity...
December 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29273557/overweight-obesity-status-in-preschool-children-associates-with-worse-asthma-but-robust-improvement-on-inhaled-corticosteroids
#11
Jason E Lang, Anne M Fitzpatrick, David T Mauger, Theresa W Guilbert, Daniel J Jackson, Robert F Lemanske, Fernando D Martinez, Robert C Strunk, Robert S Zeiger, Wanda Phipatanakul, Leonard B Bacharier, Jacqueline A Pongracic, Fernando Holguin, Michael D Cabana, Ronina A Covar, Hengameh H Raissy, Monica Tang, Stanley J Szefler
BACKGROUND: Overweight/obesity (OW) is linked to worse asthma and poorer inhaled corticosteroid (ICS) response in older children and adults. OBJECTIVE: We sought to describe the relationships between OW and asthma severity and response to ICS in preschool children. METHODS: This post hoc study of 3 large multicenter trials involving 2- to 5-year-old children compared annualized asthma symptom days and exacerbations among normal weight (NW) (body mass index: 10th-84th percentiles) versus OW (body mass index: ≥85th percentile) participants...
December 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29259221/active-passive-and-electronic-cigarette-smoking-is-associated-with-asthma-in-adolescents
#12
So Young Kim, Songyong Sim, Hyo Geun Choi
The present study investigated the associations of active, passive, and electronic cigarette (E-cigarette) smoking with asthma in Korean adolescents. We used the cross-sectional study of Korea Youth Risk Behavior Web-based Survey conducted in 2011, 2012 and 2013. Active smoking was classified into 4 groups (0 days, 1-5 days, 6-19 days, and ≥20 days a month). Passive smoking was also categorized into 4 groups (0 days, 1-2 days, 3-4 days, and ≥5 days a week). E-cigarette was defined as yes or no in the last 30 days...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251559/structural-refinement-and-prediction-of-potential-ccr2-antagonists-through-validated-multi-qsar-modeling-studies
#13
Sk Abdul Amin, Nilanjan Adhikari, Sandip Kumar Baidya, Shovanlal Gayen, Tarun Jha
Chemokines trigger numerous inflammatory responses and modulate the immune system. The interaction between monocyte chemoattractant protein-1 (MCP-1) and chemokine receptor 2 (CCR2) may be the cause of atherosclerosis, obesity and insulin resistance. However, CCR2 is also implicated in other inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, asthma and neuropathic pain. Therefore, there is a paramount importance of designing potent and selective CCR2 antagonists despite a number of drug candidates failed in clinical trials...
December 18, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29243213/accuracy-of-co-morbidity-data-in-patients-undergoing-abdominal-wall-hernia-repair-a-retrospective-study
#14
S Hajibandeh, S Hajibandeh, R Deering, D McEleney, J Guirguis, S Dix, A Sreh, E Toner, A El Muntasar, A Kausar, G Sheikh, D OShea, A Shafiq, A Kelly, A Khan, D Arumugam, A Evans
OBJECTIVES: To determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of routinely collected co-morbidity data in patients undergoing abdominal wall hernia repair. METHODS: All patients aged > 18 who underwent umbilical, para-umbilical, inguinal or incisional hernia repair between 1 January 2015 and 1 November 2016 were identified. All parts of the clinical notes were searched for co-morbidities by two authors independently...
December 14, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29238208/is-it-severe-asthma-or-asthma-with-severe-comorbidities
#15
Luisa Brussino, Paolo Solidoro, Giovanni Rolla
Severe asthma is defined as asthma that requires treatment with high-dose inhaled corticosteroids (ICSs) plus a second controller and/or systemic corticosteroids to prevent it from becoming uncontrolled or that remains uncontrolled despite this therapy. This definition has limitations: 1) it does not define any biological characteristic that distinguishes severe asthma from asthma in general and 2) it relies on the clinical interpretation of asthma symptoms that are not specific. Actually, wheezing, dyspnea, cough and chest tightness may be caused by the comorbidities (such as rhinosinusitis, obesity and vocal cord dysfunction [VCD]) which are associated with asthma...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29238123/epidemiology-triggers-and-severity-of-childhood-asthma-in-ilesa-nigeria-implications-for-management-and-control
#16
Bankole Peter Kuti, Kehinde Oluyori Omole
Background: Knowledge about childhood asthma in a locality will assist clinicians to adequately manage the condition. This study set out to report the epidemiology, triggers of exacerbation, comorbid conditions, and severity of childhood asthma at a tertiary health facility in Nigeria and the implication of these, in management and symptoms control. Methods: Over a 15-month study period, children (aged <15 years) with physician-diagnosed asthma were consecutively recruited at the pediatric chest clinic of the hospital...
January 2017: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/29229986/high-fat-diet-induced-obesity-impairs-insulin-signaling-in-lungs-of-allergen-challenged-mice-improvement-by-resveratrol
#17
Diana M André, Marina C Calixto, Carolina Sollon, Eduardo C Alexandre, Edith B G Tavares, Ana C A Naime, Gabriel F Anhê, Edson Antunes
Insulin resistance plays an important role in obesity-associated asthma exacerbations. Using a murine model of allergic airway inflammation, we evaluated the insulin signaling transmission in lungs of obese compared with lean mice. We further evaluated the effects of the polyphenol resveratrol in the pulmonary insulin signaling. In lean mice, insulin stimulation significantly increased phosphorylations of AKT, insulin receptor substrate 1 (IRS-1) and insulin receptor β (IRβ) in lung tissue and isolated bronchi (p < 0...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229888/the-association-between-body-mass-index-and-frequency-of-emergency-department-visits-and-hospitalization-for-asthma-exacerbation-in-a-pediatric-population
#18
Ghadah Abdulrahman Alhekail, Alaa Althubaiti, Sulaiman AlQueflie
BACKGROUND: The prevalence of both asthma and obesity are increasing. Although some studies suggest an association between body mass index (BMI) and frequency of emergency department (ED) visits and hospitalization for asthma exacerbation, any association remains unproven. OBJECTIVE: Estimate the frequency of asthma exacerbation in obese children, and identify any relationship between BMI and frequency of ED visits and hospitalization for asthma exacerbation. DESIGN: Retrospective review of medical records...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229090/health-related-quality-of-life-in-asthma-patients-a-comparison-of-two-cohorts-from-2005-and-2015
#19
Josefin Sundh, Philip Wireklint, Mikael Hasselgren, Scott Montgomery, Björn Ställberg, Karin Lisspers, Christer Janson
INTRODUCTION: The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. MATERIAL AND METHODS: Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t-test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29226121/facts-and-fallacies-in-the-debate-on-glyphosate-toxicity
#20
Robin Mesnage, Michael N Antoniou
The safety profile of the herbicide glyphosate and its commercial formulations is controversial. Reviews have been published by individuals who are consultants and employees of companies commercializing glyphosate-based herbicides in support of glyphosate's reapproval by regulatory agencies. These authors conclude that glyphosate is safe at levels below regulatory permissible limits. In contrast, reviews conducted by academic scientists independent of industry report toxic effects below regulatory limits, as well as shortcomings of the current regulatory evaluation of risks associated with glyphosate exposures...
2017: Frontiers in Public Health
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