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https://www.readbyqxmd.com/read/27687251/fully-automated-structural-mri-of-the-brain-in-clinical-dementia-workup
#1
Karin Persson, Geir Selbæk, Anne Brækhus, Mona Beyer, Maria Barca, Knut Engedal
BACKGROUND: The dementia syndrome has been regarded a clinical diagnosis but the focus on supplemental biomarkers is increasing. An automatic magnetic resonance imaging (MRI) volumetry method, NeuroQuant® (NQ), has been developed for use in clinical settings. PURPOSE: To evaluate the clinical usefulness of NQ in distinguishing Alzheimer's disease dementia (AD) from non-dementia and non-AD dementia. MATERIAL AND METHODS: NQ was performed in 275 patients diagnosed according to the criteria of ICD-10 for AD, vascular dementia and Parkinson's disease dementia (PDD); the Winblad criteria for mild cognitive impairment; the Lund-Manchester criteria for frontotemporal dementia; and the revised consensus criteria for Lewy body dementia (LBD)...
September 28, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27071647/automated-brain-volumetrics-in-multiple-sclerosis-a-step-closer-to-clinical-application
#2
C Wang, H N Beadnall, S N Hatton, G Bader, D Tomic, D G Silva, M H Barnett
BACKGROUND: Whole brain volume (WBV) estimates in patients with multiple sclerosis (MS) correlate more robustly with clinical disability than traditional, lesion-based metrics. Numerous algorithms to measure WBV have been developed over the past two decades. We compare Structural Image Evaluation using Normalisation of Atrophy-Cross-sectional (SIENAX) to NeuroQuant and MSmetrix, for assessment of cross-sectional WBV in patients with MS. METHODS: MRIs from 61 patients with relapsing-remitting MS and 2 patients with clinically isolated syndrome were analysed...
July 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26244349/evoked-potentials-and-memory-cognition-tests-validate-brain-atrophy-as-measured-by-3t-mri-neuroquant-in-cognitively-impaired-patients
#3
Eric R Braverman, Kenneth Blum, Karl L Hussman, David Han, Kristina Dushaj, Mona Li, Gabriela Marin, Rajendra D Badgaiyan, Richard Smayda, Mark S Gold
To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) displayed increased areas of anatomical atrophy: 34.62% hippocampal atrophy (N=54), 57.14% central atrophy (N=88), and 44.52% temporal atrophy (N=69). A majority of these patients exhibited overlap in measured areas of atrophy and were cognitively impaired...
2015: PloS One
https://www.readbyqxmd.com/read/26127375/su-e-i-70-comparison-of-brain-volume-quantification-with-neuroquant-freesurfer
#4
Y Zhou, J Zambelli, G Heredia
PURPOSE: This study is to evaluate the precision of volumetric evaluation using two types of image processing platforms with the MRI images obtained on a single subject from different types of scanners. METHODS: The MRI scans have been performed on a single healthy volunteer during a span of 3 months using the parameters specified by the NeuroQuant manufacturer. The imaging parameters can be found at http://www.cortechslabs.com/resources/#EDUCATIONTRAINING-0. Nine scanners with field strengths of 1...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/25923853/man-versus-machine-part-2-comparison-of-radiologists-interpretations-and-neuroquant-measures-of-brain-asymmetry-and-progressive-atrophy-in-patients-with-traumatic-brain-injury
#5
David E Ross, Alfred L Ochs, Megan E DeSmit, Jan M Seabaugh, Michael D Havranek
This study is an expanded version of an earlier study, which compared NeuroQuant measures of MRI brain volume with the radiologist's traditional approach in outpatients with mild or moderate traumatic brain injury. NeuroQuant volumetric analyses were compared with the radiologists' interpretations. NeuroQuant found significantly higher rates of atrophy (50.0%), abnormal asymmetry (83.3%), and progressive atrophy (70.0%) than the radiologists (12.5%, 0% and 0%, respectively). Overall, NeuroQuant was more sensitive for detecting at least one sign of atrophy, abnormal asymmetry, or progressive atrophy (95...
2015: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/25907519/mesial-temporal-sclerosis-accuracy-of-neuroquant-versus-neuroradiologist
#6
M Azab, M Carone, S H Ying, D M Yousem
BACKGROUND AND PURPOSE: We sought to compare the accuracy of a volumetric fully automated computer assessment of hippocampal volume asymmetry versus neuroradiologists' interpretations of the temporal lobes for mesial temporal sclerosis. Detecting mesial temporal sclerosis (MTS) is important for the evaluation of patients with temporal lobe epilepsy as it often guides surgical intervention. One feature of MTS is hippocampal volume loss. MATERIALS AND METHODS: Electronic medical record and researcher reports of scans of patients with proved mesial temporal sclerosis were compared with volumetric assessment with an FDA-approved software package, NeuroQuant, for detection of mesial temporal sclerosis in 63 patients...
August 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/25727700/comparison-of-automated-brain-volume-measures-obtained-with-neuroquant-and-freesurfer
#7
COMPARATIVE STUDY
Alfred L Ochs, David E Ross, Megan D Zannoni, Tracy J Abildskov, Erin D Bigler
PURPOSE: To examine intermethod reliabilities and differences between FreeSurfer and the FDA-cleared congener, NeuroQuant, both fully automated methods for structural brain MRI measurements. MATERIALS AND METHODS: MRI scans from 20 normal control subjects, 20 Alzheimer's disease patients, and 20 mild traumatically brain-injured patients were analyzed with NeuroQuant and with FreeSurfer. Intermethod reliability was evaluated. RESULTS: Pairwise correlation coefficients, intraclass correlation coefficients, and effect size differences were computed...
September 2015: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/25109528/back-to-the-future-estimating-pre-injury-brain-volume-in-patients-with-traumatic-brain-injury
#8
David E Ross, Alfred L Ochs, Megan D Zannoni, Jan M Seabaugh
INTRODUCTION: A recent meta-analysis by Hedman et al. allows for accurate estimation of brain volume changes throughout the life span. Additionally, Tate et al. showed that intracranial volume at a later point in life can be used to estimate reliably brain volume at an earlier point in life. These advancements were combined to create a model which allowed the estimation of brain volume just prior to injury in a group of patients with mild or moderate traumatic brain injury (TBI). This volume estimation model was used in combination with actual measurements of brain volume to test hypotheses about progressive brain volume changes in the patients...
November 15, 2014: NeuroImage
https://www.readbyqxmd.com/read/24946038/structural-brain-abnormalities-in-patients-with-inflammatory-illness-acquired-following-exposure-to-water-damaged-buildings-a-volumetric-mri-study-using-neuroquant%C3%A2
#9
Ritchie C Shoemaker, Dennis House, James C Ryan
Executive cognitive and neurologic abnormalities are commonly seen in patients with a chronic inflammatory response syndrome (CIRS) acquired following exposure to the interior environment of water-damaged buildings (WDB), but a clear delineation of the physiologic or structural basis for these abnormalities has not been defined. Symptoms of affected patients routinely include headache, difficulty with recent memory, concentration, word finding, numbness, tingling, metallic taste and vertigo. Additionally, persistent proteomic abnormalities in inflammatory parameters that can alter permeability of the blood-brain barrier, such as C4a, TGFB1, MMP9 and VEGF, are notably present in cases of CIRS-WDB compared to controls, suggesting a consequent inflammatory injury to the central nervous system...
September 2014: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/24709384/rbans-memory-indices-are-related-to-medial-temporal-lobe-volumetrics-in-healthy-older-adults-and-those-with-mild-cognitive-impairment
#10
Heather B England, M Meredith Gillis, Benjamin M Hampstead
The current study (i) determined whether NeuroQuant(®) volumetrics are reflective of differences in medial temporal lobe (MTL) volumes between healthy older adults and those with mild cognitive impairment (MCI) and (ii) examined the relationship between RBANS indices and MTL volumes. Forty-three healthy older adults and 57 MCI patients completed the RBANS and underwent structural MRI. Hippocampal and inferior lateral ventricle (ILV) volumes were obtained using NeuroQuant(®). Results revealed significantly smaller hippocampal and larger ILV volumes in MCI patients...
June 2014: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/24211008/operationalizing-hippocampal-volume-as-an-enrichment-biomarker-for-amnestic-mild-cognitive-impairment-trials-effect-of-algorithm-test-retest-variability-and-cut-point-on-trial-cost-duration-and-sample-size
#11
Peng Yu, Jia Sun, Robin Wolz, Diane Stephenson, James Brewer, Nick C Fox, Patricia E Cole, Clifford R Jack, Derek L G Hill, Adam J Schwarz
The objective of this study was to evaluate the effect of computational algorithm, measurement variability, and cut point on hippocampal volume (HCV)-based patient selection for clinical trials in mild cognitive impairment (MCI). We used normal control and amnestic MCI subjects from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) as normative reference and screening cohorts. We evaluated the enrichment performance of 4 widely used hippocampal segmentation algorithms (FreeSurfer, Hippocampus Multi-Atlas Propagation and Segmentation (HMAPS), Learning Embeddings Atlas Propagation (LEAP), and NeuroQuant) in terms of 2-year changes in Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and Clinical Dementia Rating Sum of Boxes (CDR-SB)...
April 2014: Neurobiology of Aging
https://www.readbyqxmd.com/read/23487191/man-versus-machine-comparison-of-radiologists-interpretations-and-neuroquant%C3%A2-volumetric-analyses-of-brain-mris-in-patients-with-traumatic-brain-injury
#12
COMPARATIVE STUDY
David E Ross, Alfred L Ochs, Jan M Seabaugh, Carole R Shrader
NeuroQuant® is a recently developed, FDA-approved software program for measuring brain MRI volume in clinical settings. The purpose of this study was to compare NeuroQuant with the radiologist's traditional approach, based on visual inspection, in 20 outpatients with mild or moderate traumatic brain injury (TBI). Each MRI was analyzed with NeuroQuant, and the resulting volumetric analyses were compared with the attending radiologist's interpretation. The radiologist's traditional approach found atrophy in 10...
2013: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/22929941/diagnosis-of-dementia-automatic-quantification-of-brain-structures
#13
Knut Engedal, Anne Brækhus, Ole A Andreassen, Per Hj Nakstad
BACKGROUND: The aim of the present study was to examine the usefulness of a fully automatic quantification of brain structures by means of magnetic resonance imaging (MRI) for diagnosing dementia of the Alzheimer's type (DAT). MATERIAL AND METHOD: MRI scans of the brains of 122 patients, referred to a memory clinic, were analysed using Neuroquant® software, which quantifies the volume of various brain structures. Clinical diagnoses were made by two doctors without knowledge of the MRI results...
August 21, 2012: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/22723496/temporal-lobe-epilepsy-quantitative-mr-volumetry-in-detection-of-hippocampal-atrophy
#14
Nikdokht Farid, Holly M Girard, Nobuko Kemmotsu, Michael E Smith, Sebastian W Magda, Wei Y Lim, Roland R Lee, Carrie R McDonald
PURPOSE: To determine the ability of fully automated volumetric magnetic resonance (MR) imaging to depict hippocampal atrophy (HA) and to help correctly lateralize the seizure focus in patients with temporal lobe epilepsy (TLE). MATERIALS AND METHODS: This study was conducted with institutional review board approval and in compliance with HIPAA regulations. Volumetric MR imaging data were analyzed for 34 patients with TLE and 116 control subjects. Structural volumes were calculated by using U...
August 2012: Radiology
https://www.readbyqxmd.com/read/22721509/progressive-brain-atrophy-in-patients-with-chronic-neuropsychiatric-symptoms-after-mild-traumatic-brain-injury-a-preliminary-study
#15
COMPARATIVE STUDY
David E Ross, Alfred L Ochs, Jan M Seabaugh, Michael F Demark, Carole R Shrader, Jennifer H Marwitz, Michael D Havranek
INTRODUCTION: NeuroQuant® is a recently developed, FDA-approved software program for measuring brain MRI volume in clinical settings. The aims of this study were as follows: (1) to examine the test-retest reliability of NeuroQuant®; (2) to test the hypothesis that patients with mild traumatic brain injury (TBI) would have abnormally rapid progressive brain atrophy; and (3) to test the hypothesis that progressive brain atrophy in patients with mild TBI would be associated with vocational outcome...
2012: Brain Injury: [BI]
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