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https://www.readbyqxmd.com/read/28319561/pediatric-enteric-neuropathies-diagnosis-and-current-management
#1
Maggie L Westfal, Allan M Goldstein
PURPOSE OF REVIEW: Neurointestinal diseases are increasingly recognized as causes of significant gastrointestinal morbidity in children. This review highlights the most common pediatric enteric neuropathies and their diagnosis and management, emphasizing insights and discoveries from the most recent literature available. RECENT FINDINGS: The embryologic and histopathologic causes of enteric neuropathies are varied. They range from congenital aganglionosis in Hirschsprung disease, to autoimmune-mediated loss of neuronal subtypes in esophageal achalasia and Chagas disease, to degenerative neuropathies in some cases of chronic intestinal pseudo-obstruction and gastroparesis...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28316976/mutagenic-and-cytotoxicity-lqb-123-profile-safety-and-tripanocidal-effect-of-a-phenyl-t-butylnitrone-derivative
#2
Mauricio Peixoto Cupello, Francis Monique Saraiva, Pedro Ippolito, Andréia da Silva Fernandes, Rubem Figueiredo Sadoko Menna-Barreto, Debora de Sousa Dos Santos Costa, Jessica Isis Oliveira Paula, Paulo Roberto Ribeiro Costa, Natália Pereira Nogueira, Israel Felzenswalb, Ayres Guimarães Dias, Marcia Cristina Paes
The therapeutic options for Chagas disease are limited and its treatment presents a number of drawbacks including toxicity, drug resistance, and insufficient effectiveness against the chronic stage of the disease. Therefore, new therapeutical options are mandatory. In the present work, we evaluated the effect of a phenyl-tert-butylnitrone (PBN) derivate, LQB 123, against Trypanosoma cruzi forms. LQB 123 presented a trypanocidal effect against bloodstream trypomastigotes (IC50 = 259.4 ± 6.1 μM) and intracellular amastigotes infecting peritoneal macrophages (IC50 = 188...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28316108/cry1a-b-16-toxin-from-bacillus-thuringiensis-theoretical-refinement-of-three-dimensional-structure-and-prediction-of-peptides-as-molecular-markers-for-detection-of-genetically-modified-organisms
#3
Alexandra Plácido, Andreia Coelho, Lucas Abreu do Nascimento, Andreanne Gomes Vasconcelos, Maria Fátima Barroso, Joilson Ramos-Jesus, Vladimir Costa, Francisco das Chagas Alves Lima, Cristina Delerue-Matos, Ricardo Martins Ramos, Mariela M Marani, José Roberto de Souza de Almeida Leite
Transgenic maize produced by the insertion of the Cry transgene into its genome became the second most cultivated crop worldwide. Cry gene from Bacillus thuringiensis kurstaki expresses protein derivatives of crystalline endotoxins which confer insect resistance onto the maize crop. Mandatory labeling of processed food containing or made by genetically modified organisms is in force in many countries, so, it is very urgent to develop fast and practical methods for GMO identification, e.g., biosensors. In the absence of an available empirical structure of Cry1A(b)16 protein, a theoretical model was effectively generated, in this work, by homology modeling and molecular dynamics simulations based on two available homologous protein structures...
March 18, 2017: Proteins
https://www.readbyqxmd.com/read/28306713/trypanocidal-effect-of-isotretinoin-through-the-inhibition-of-polyamine-and-amino-acid-transporters-in-trypanosoma-cruzi
#4
Chantal Reigada, Edward A Valera-Vera, Melisa Sayé, Andrea E Errasti, Carla C Avila, Mariana R Miranda, Claudio A Pereira
Polyamines are essential compounds to all living organisms and in the specific case of Trypanosoma cruzi, the causative agent of Chagas disease, they are exclusively obtained through transport processes since this parasite is auxotrophic for polyamines. Previous works reported that retinol acetate inhibits Leishmania growth and decreases its intracellular polyamine concentration. The present work describes a combined strategy of drug repositioning by virtual screening followed by in vitro assays to find drugs able to inhibit TcPAT12, the only polyamine transporter described in T...
March 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28304254/clinical-trypanosoma-cruzi-disease-after-cardiac-transplantation-in-a-cynomolgus-macaque-macaca-fascicularis
#5
Elana R Rybak, Steve Shipley, Ivan Tatarov, Tianshu Zhang, Wenji Sun, Gheorghe Braileanu, Lars Burdorf, Evelyn Sievert, Agnes M Azimzadeh, Louis J DeTolla, Richard N Pierson Iii
A cynomolgus macaque received a heterotopic cardiac allograft as part of a transplant study, with monoclonal antibodies targeted to specific immune costimulation molecules (CD154, CD28) but no traditional immunosuppressive therapy after surgery. Clinical anemia was detected on postoperative day (POD) 35 and had worsened (Hgb, 2.3 g/dL; Hct = 7.3%) by POD 47, despite type-matched whole-blood transfusions. After a total of 4 blood transfusions, hematologic parameters were improved (Hgb, 5.9 g/dL; Hct, 18.7%)...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28302040/trypanothione-reductase-a-target-for-the-development-of-anti-trypanosoma-cruzi-drugs
#6
Karina Vázquez, Margot Paulino, Cristian O Salas, Juan J Zarate-Ramos, Brenda Vera, Gildardo Rivera
Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with treatment available via two drugs: nifurtimox and benznidazole. These two treatments are ineffective in the chronic phase of the disease. Therefore, there is a need for the development of new, efficient and safe drugs for the treatment of these diseases. With this goal, one of the promising targets proposed is the trypanothione reductase (TR), a key enzyme important in the metabolism of Trypanosoma cruzi. In this review, we analyze the importance of TR as a drug target, as well as their compounds inhibitors reported in the last decade as potential therapeutic agents for Chagas disease...
March 15, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28298240/interstrain-differences-in-the-expression-and-activity-of-cyp2a5-in-the-mouse-liver
#7
Katia S Poça, Thiago E M Parente, Lucas F Chagas, Bruna S Leal, Hellen S Leal, Francisco J R Paumgartten, Ana C A X De-Oliveira
BACKGROUND: Cytochrome P450 2A5 (Cyp2a5), a mouse enzyme orthologous of human CYP2A6, catalyzes a number of toxicologically important reactions, including the metabolism of nicotine, aflatoxin B1, and several other xeno- and endobiotics. Cyp2a5 expression is complex and not yet fully understood. We investigated inter-strain differences in the activity and mRNA expression of hepatic Cyp2a5. Cyp1a1/2 and Cyp2b9/10 activities were evaluated for comparative purposes. Data on the interstrain differences in the expression and activity of Cyp2a5 are important to select a suitable mouse model for studying CYP2A6-mediated metabolism...
March 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28296386/direct-drawing-method-of-graphite-onto-paper-for-high-performance-flexible-electrochemical-sensors
#8
Murilo Santhiago, Mathias Strauss, Mariane Peres Pereira, Andréia S Chagas, Carlos César Bof Bufon
A simple and fast fabrication method to create high performance pencil-drawn electrochemical sensors is reported for the first time. The sluggish electron transfer observed on bare pencil-drawn surfaces was enhanced using two electrochemical steps: first oxidizing the surface and then reducing it in a subsequent step. The heterogeneous rate constant was found to be 5.1×10(-3) cm s(-1), which is the highest value reported so far for pencil-drawn surfaces. We have mapped the origin of such performance by atomic force microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28294160/immune-complexes-in-chronic-chagas-disease-patients-are-formed-by-exovesicles-from-trypanosoma-cruzi-carrying-the-conserved-masp-n-terminal-region
#9
Isabel María Díaz Lozano, Luis Miguel De Pablos, Silvia Andrea Longhi, María Paola Zago, Alejandro Gabriel Schijman, Antonio Osuna
The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MASP multigene family of proteins MASPs are specific to this parasite and characterized by a conserved C-terminal (C-term) region and an N-terminal codifying for a signal peptide (SP). In this investigation, we identified immature MASP proteins containing the MASP SP in EVs secreted by the infective forms of the parasite...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293288/techno-economic-analysis-and-climate-change-impacts-of-sugarcane-biorefineries-considering-different-time-horizons
#10
Tassia L Junqueira, Mateus F Chagas, Vera L R Gouveia, Mylene C A F Rezende, Marcos D B Watanabe, Charles D F Jesus, Otavio Cavalett, Artur Y Milanez, Antonio Bonomi
BACKGROUND: Ethanol production from lignocellulosic feedstocks (also known as 2nd generation or 2G ethanol process) presents a great potential for reducing both ethanol production costs and climate change impacts since agricultural residues and dedicated energy crops are used as feedstock. This study aimed at the quantification of the economic and environmental impacts considering the current and future scenarios of sugarcane biorefineries taking into account not only the improvements of the industrial process but also of biomass production systems...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28291051/30-day-readmission-rates-in-an-hiv-infected-cohort-from-rio-de-janeiro-brazil
#11
Lara E Coelho, Sayonara R Ribeiro, Andre M Japiassu, Ronaldo I Moreira, Priscila C Lara, Valdilea G Veloso, Beatriz Grinsztejn, Paula M Luz
BACKGROUND: The 30-day readmission rate is an indicator of the quality of hospital care and transition to the outpatient setting. Recent studies suggest HIV infection might increase the risk of readmission though estimates of 30-day readmission rates are unavailable among HIV infected individuals living in middle/low income settings. Additionally, factors that may increase readmission risk in HIV infected populations are poorly understood. METHODS: 30-day readmission rates were estimated for HIV-infected adults from the Instituto Nacional de Infectologia Evandro Chagas/Fiocruz cohort in Rio de Janeiro, Brazil, from January 2007 to December 2013...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28290809/-role-of-autoantibodies-against-1-adrenergic-receptor-in-cardiovascular-disease
#12
M V Kostyukevich, K A Zykov, N A Mironova, O Y Agapova, A Y Shevelev, E E Efremov, T N Vlasik, S P Golitsyn
According to current knowledge, autoantibodies against 1-adrenergic receptors may be involved in pathogenesis of different cardiovascular diseases and are mostly studied in patients with Chagas disease, dilated cardiomyopathy and heart rhythm disorders. They may play an important role in cardiomyocyte apoptosis, alteration of their chrono- and inotropic effects and electrophysiological characteristics. Their effects are transduced via 1-adrenergic receptors and depend on multiple factors as ligand properties, durability of its coupling with the receptor, amount of receptors on the cell surface, their affinity and conformation...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28289519/challenges-in-the-chemotherapy-of-chagas-disease-looking-for-possibilities-related-to-the-differences-and-similarities-between-the-parasite-and-host
#13
REVIEW
Vitor Sueth-Santiago, Debora Decote-Ricardo, Alexandre Morrot, Celio Geraldo Freire-de-Lima, Marco Edilson Freire Lima
Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.
February 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28289021/prevalence-of-right-ventricular-dysfunction-in-chagas-disease-does-this-depend-on-the-method-used-usefulness-of-cardiac-magnetic-resonance
#14
EDITORIAL
Maria Carmo P Nunes, Harry Acquatella
No abstract text is available yet for this article.
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28289020/evaluation-of-right-ventricular-systolic-function-in-chagas-disease-using-cardiac-magnetic-resonance-imaging
#15
Henrique T Moreira, Gustavo J Volpe, José A Marin-Neto, Bharath Ambale-Venkatesh, Chike C Nwabuo, Henrique S Trad, Minna M D Romano, Antonio Pazin-Filho, Benedito C Maciel, João A C Lima, André Schmidt
BACKGROUND: Right ventricular (RV) impairment is postulated to be responsible for prominent systemic congestion in Chagas disease. However, occurrence of primary RV dysfunction in Chagas disease remains controversial. We aimed to study RV systolic function in patients with Chagas disease using cardiac magnetic resonance. METHODS AND RESULTS: This cross-sectional study included 158 individuals with chronic Chagas disease who underwent cardiac magnetic resonance. RV systolic dysfunction was defined as reduced RV ejection fraction based on predefined cutoffs accounting for age and sex...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28285728/chagas-disease-an-important-cause-of-megaesophagus-in-latin-america
#16
Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti
No abstract text is available yet for this article.
March 9, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28285511/differential-effects-of-two-widely-used-solvents-dmso-and-ethanol-on-the-growth-and-recovery-of-trypanosoma-cruzi-epimastigotes-in-culture
#17
Ana María Cevallos, Juliana Herrera, Imelda López-Villaseñor, Roberto Hernández
Trypanosoma cruzi is the etiological agent of Chagas disease. Epimastigote forms of T. cruzi can be readily cultured in axenic conditions. Ethanol and dimethyl sulfoxide (DMSO) are commonly used solvents employed as vehicles for hydrophobic compounds. In order to produce a reference plot of solvent dependent growth inhibition for T. cruzi research, the growth of epimastigotes was analyzed in the presence of different concentrations of ethanol (0.1-4.0%) and DMSO (0.5-7.5%). The ability of the parasites to resume growth after removal of these solvents was also examined...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28285362/purinergic-ecto-enzymes-participate-in-the-thromboregulation-in-acute-in-mice-infection-by-trypanosoma-cruzi
#18
Guilherme M do Carmo, Pedro H Doleski, Mariângela F de Sá, Thirssa H Grando, Nathieli B Bottari, Daniela B R Leal, Lucas T Gressler, Ricardo E Mendes, Lenita M Stefani, Silvia G Monteiro, Aleksandro S Da Silva
Coagulation disorders have been described in Chagas disease with thrombocytopenia as an important event. Several mechanisms may be related to this pathogenesis, such as enzymes of the purinergic system, purine, and receptors involved in the regulation and modulation of physiological events related to hemostasis. Therefore, the aim of this study was to evaluate the activities of E-NTPDase, E-5'nucleotidase, and ecto-adenosine deaminase (E-ADA) in platelets of mice experimentally infected by Trypanosoma cruzi...
March 11, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28285268/cardiac-manifestations-of-parasitic-diseases
#19
REVIEW
Maria Carmo P Nunes, Milton Henriques Guimarães Júnior, Adriana Costa Diamantino, Claudio Leo Gelape, Teresa Cristina Abreu Ferrari
The heart may be affected directly or indirectly by a variety of protozoa and helminths. This involvement may manifest in different ways, but the syndromes resulting from impairment of the myocardium and pericardium are the most frequent. The myocardium may be invaded by parasites that trigger local inflammatory response with subsequent myocarditis or cardiomyopathy, as occurs in Chagas disease, African trypanosomiasis, toxoplasmosis, trichinellosis and infection with free-living amoebae. In amoebiasis and echinococcosis, the pericardium is the structure most frequently involved with consequent pericardial effusion, acute pericarditis, cardiac tamponade or constrictive pericarditis...
March 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28284860/synthesis-and-activity-of-nucleoside-based-antiprotozoan-compounds
#20
Huu-Anh Tran, Zhaoyan Zheng, Xianghui Wen, Srinivasan Manivannan, Arnaud Pastor, Marcel Kaiser, Reto Brun, Floyd F Snyder, Thomas G Back
Parasitic protozoa employ a salvage pathway to synthesize purines and generate essential active nucleotides, whereas mammals are capable of their de novo biosynthesis. This difference provides opportunity for the design of potential new antiprotozoan compounds. A series of 47 adenosine analogues was prepared with modifications at the 2-, 6- and 5'-positions, based on the hypothesis that such compounds would serve as substrates for protozoan nucleoside salvage enzymes, while remaining refractory in mammalian cells...
February 16, 2017: Bioorganic & Medicinal Chemistry
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