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Harsh Agrawal, Mohamed Teleb, Saba Lahsaei, Luis Carbajal, Ruben Montanez, Joseph P Carrozza
PURPOSE OF THE REVIEW: Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revascularization (CR) if at all possible. However, restenosis and stent thrombosis (ST) remain the Achilles heel of contemporary PCI with restenosis rates between 10 and 30% with bare metal stents to 5-15% after drug-eluting stents and ST rates of around 0...
March 6, 2018: Current Cardiology Reports
Suzanne H Richards, Lindsey Anderson, Caroline E Jenkinson, Ben Whalley, Karen Rees, Philippa Davies, Paul Bennett, Zulian Liu, Robert West, David R Thompson, Rod S Taylor
BACKGROUND: Coronary heart disease (CHD) is the most common cause of death globally, although mortality rates are falling. Psychological symptoms are prevalent for people with CHD, and many psychological treatments are offered following cardiac events or procedures with the aim of improving health and outcomes. This is an update of a Cochrane systematic review previously published in 2011. OBJECTIVES: To assess the effectiveness of psychological interventions (alone or with cardiac rehabilitation) compared with usual care (including cardiac rehabilitation where available) for people with CHD on total mortality and cardiac mortality; cardiac morbidity; and participant-reported psychological outcomes of levels of depression, anxiety, and stress; and to explore potential study-level predictors of the effectiveness of psychological interventions in this population...
April 28, 2017: Cochrane Database of Systematic Reviews
Xinyu Yang, Yanda Li, Xiaomeng Ren, Xingjiang Xiong, Lijun Wu, Jie Li, Jie Wang, Yonghong Gao, Hongcai Shang, Yanwei Xing
In this study, we assessed the effect of rehabilitation exercise after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). We performed a meta-analysis to determine the effects of exercise in patients after PCI. The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, the Embase database, China National Knowledge Internet (CNKI), China Biology Medicine (CBM), and the Wanfang Database were searched for randomized controlled trials (RCTs). The key words used for the searches were PCI, exercise, walking, jogging, Tai Chi, and yoga...
March 17, 2017: Scientific Reports
Hirofumi Hioki, Takashi Miura, Hirohiko Motoki, Hideki Kobayashi, Masanori Kobayashi, Hiroyuki Nakajima, Hikaru Kimura, Eiichiro Mawatari, Hiroshi Akanuma, Toshio Sato, Souichirou Ebisawa, Yusuke Miyashita, Uichi Ikeda, Shoji Hotta, Yuichi Kamiyoshi, Takuya Maruyama, Noboru Watanabe, Takayuki Eisawa, Shinichi Aso, Shinichirou Uchikawa, Naoto Hashizume, Noriyuki Sekimura, Takehiro Morita
OBJECTIVE: Little is known about the relationship between body composition indicators, including body mass index (BMI), fat mass index (FMI) and lean BMI (LBMI), and adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify this relationship. METHODS: The SHINANO registry is a prospective, observational, multicenter cohort registry that enrolled 1923 consecutive patients with coronary heart disease (CHD) from August 2012 to July 2013; 66 patients were excluded because of missing data...
2015: Heart Asia
Anurag Bajaj, Ankur Sethi, Parul Rathor, Nissi Suppogu, Arjinder Sethi
Coronary heart disease is a major cause of mortality and morbidity worldwide. The incidence of mechanical complications of acute myocardial infarction (AMI) has gone down to less than 1% since the advent of percutaneous coronary intervention, but although mortality resulting from AMI has gone down in recent years, the burden remains high. Mechanical complications of AMI include cardiogenic shock, free wall rupture, ventricular septal rupture, acute mitral regurgitation, and right ventricular infarction. Detailed knowledge of the complications and their risk factors can help clinicians in making an early diagnosis...
October 2015: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Lloyd Steele, Amelia Lloyd, James Fotheringham, Ayyaz Sultan, Javaid Iqbal, Ever D Grech
BACKGROUND: Cigarette smoking is a well-established risk factor for the development of coronary heart disease. However, the relationship between smoking and acute ST-segment elevation myocardial infarction (STEMI) is less well described. OBJECTIVE: To determine the relative risk of acute STEMI in smokers and ex-smokers, compared with individuals who had never smoked. METHODS: This observational study studied all patients with STEMI undergoing percutaneous coronary intervention (PCI) in South Yorkshire, UK from 1 January 2009 to 6 April 2012...
September 2015: Postgraduate Medical Journal
Hisashi Makino, Yoshihiro Miyamoto, Akie Kikuchi-Taura, Toshihiro Soma, Akihiko Taguchi, Ichiro Kishimoto
AIMS/INTRODUCTION: Circulating progenitor cells, including CD34 positive (CD34(+)) cells, play a key role in neovascularisation and the maintenance of vascular endothelial function. Several lines of evidence show an association between decreased levels of circulating CD34(+) cells and cardiovascular disease. However, the contribution of circulating CD34(+) cells to the occurrence of cardiovascular events in diabetic patients remains unclear. MATERIALS AND METHODS: In the present study with a median follow up of 4...
July 2015: Journal of Diabetes Investigation
Guangjin Luo, Qingman Li, Xiajun Zhang, Liang Shen, Jiahe Xie, Jingwen Zhang, Masafumi Kitakaze, Xiaobo Huang, Yulin Liao
Endoplasmic reticulum stress is a proapoptotic and profibrotic stimulus. Ablation of C/EBP homologous protein (CHOP) is reported to reverse cardiac dysfunction by attenuating cardiac endoplasmic reticulum stress in mice with pressure overload or ischemia/reperfusion, but it is unclear whether loss of CHOP also inhibits cardiac remodeling induced by permanent-infarction. In mice with permanent ligation of left coronary artery, we found that ablation of CHOP increased the acute phase mortality. For the mice survived to 4 weeks, left ventricular anterior (LV) wall thickness was larger in CHOP knockout mice than in the wildtype littermates, while no difference was noted on posterior wall thickness, LV dimensions, LV fractional shortening and ejection fraction...
August 14, 2015: Biochemical and Biophysical Research Communications
Bo-Da Zhou, Ling-Yun Zu, Lin Mi, Gui-Song Wang, Li-Jun Guo, Wei Gao
BACKGROUND: There are patients who underwent emergency coronary angiography (CAG) but did not receive percutaneous coronary intervention (PCI). The aim of this study was to analyze these reasons. METHODS: This is a single-center retrospective study. We recruited 201 consecutive patients who received emergency CAG but did not receive PCI. To investigate the value of the Global Registry of Acute Coronary Events (GRACE) score in predicting PCI possibilities in non-ST segment elevation acute coronary syndrome (NSTE-ACS) patients, we recruited 80 consecutive patients who presented with NSTE-ACS and received emergency CAG as well as emergency PCI...
May 2015: Journal of Geriatric Cardiology: JGC
Machaon M Bonafede, Barbara H Johnson, Akshara Richhariya, Shravanthi R Gandra
OBJECTIVES: This study descriptively examined acute and longer term direct medical costs associated with a major cardiovascular (CV) event among high-risk coronary heart disease risk-equivalent (CHD-RE) patients. It also gives a firsthand look at fatal versus nonfatal CV events. METHODS: The MarketScan(®) Commercial Claims and Encounters Database was used to identify adults with a CV event in 2006-2012 with hyperlipidemia or lipid-lowering therapy use in the 18 months prior to one of the following inpatient CV events: myocardial infarction, ischemic stroke, unstable angina, transient ischemic attack, percutaneous coronary intervention, or coronary artery bypass graft (CABG)...
2015: ClinicoEconomics and Outcomes Research: CEOR
Chen Mao, Xiao-Hong Fu, Jin-Qiu Yuan, Zu-Yao Yang, Vincent C H Chung, Ying Qin, Yafang Huang, Wilson Wai San Tam, Joey S W Kwong, Wei Xie, Jin-Ling Tang
BACKGROUND: Percutaneous coronary intervention (PCI) is a standard treatment for coronary heart disease (CHD). Restenosis, defined as a 50% reduction in luminal diameter at six months after PCI, indicates a need for revascularisation. Restenosis has proven to be a major drawback to PCI. Tong-xin-luo is one of the prophylactic strategies for cardiovascular events in patients after PCI that is widely used in China, but its efficacy and safety have not been systematically evaluated. OBJECTIVES: To systematically assess the efficacy and safety of Tong-xin-luo capsules in preventing cardiovascular events after PCI in patients with CHD...
2015: Cochrane Database of Systematic Reviews
Jiao Wang, Zhi-Qiang Liu, Peng-Yi He, Yu-Chun Yang, Lei Zhang, Muhuyati
To discuss the risk factors and characteristics of coronary artery disease of Han, Uygur and Kazak patients with acute myocardial infarction in Xinjiang district. A retrospective analysis of clinical data of 262 cases of Han patients, 166 cases of Uygur patients and 86 cases of Kazak patients was conducted, whose age, body mass index, cholesterol, uric acid, hypertension, type 2 diabetes, smoking, drinking, family history of coronary heart disease, relationship between PCI history and pathogenesis of acute myocardial infarction, and coronary artery disease characteristics were observed and compared in different groups...
2015: International Journal of Clinical and Experimental Medicine
Taek Min Nam, Kyung Il Jo, Je Young Yeon, Seung Chyul Hong, Jong Soo Kim
The purpose of this study was to determine the prevalence and characteristics of symptomatic coronary heart disease (CHD) in patients with moyamoya disease (MMD). This retrospective study evaluated 456 patients who received examination for MMD between 1995 and 2012. We reviewed the patients' medical history and coronary imaging, including conventional coronary angiography and coronary computed tomography angiogram (CTA). Among 456 patients with MMD, 21 (4.6%) patients were found to have symptomatic CHD. Ten patients were treated with coronary artery bypass graft or percutaneous coronary intervention for unstable angina or myocardial infarction...
April 2015: Journal of Korean Medical Science
Hilde E Groot, Minke H T Hartman, Youlan L Gu, Bart J G L de Smet, Ad F M van den Heuvel, Erik Lipsic, Pim van der Harst
AIMS: Interleukin-6 receptor (IL-6R) signalling has been suggested to play a causal role in the development and outcome of coronary heart disease (CHD). The aim of this study was to investigate the association of sIL-6R levels with myocardial reperfusion after percutaneous coronary intervention (PCI) for acute ST-elevated myocardial infarction (STEMI). METHODS: Blood was sampled from 70 patients presenting with STEMI at 6 different time-points (baseline, post-PCI, t=1h, t=6h, t=24h, t=2w)...
June 2015: Cytokine
Hemal Gada, Ajay J Kirtane, Dean J Kereiakes, Sripal Bangalore, Jeffrey W Moses, Philippe Généreux, Roxana Mehran, George D Dangas, Martin B Leon, Gregg W Stone
Outcomes of percutaneous coronary intervention (PCI) versus medical therapy (MT) in the management of stable ischemic heart disease (SIHD) remain controversial, with some but not all studies showing improved results in patients with ischemia. We sought to elucidate whether PCI improves mortality compared to MT in patients with objective evidence of ischemia (assessed using noninvasive imaging or its invasive equivalent). We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing PCI to MT in patients with SIHD...
May 1, 2015: American Journal of Cardiology
Jiantao Li, Yunfeng Han, Jing Jing, Shengxian Tu, Weiren Chen, Johan H C Reiber, Yundai Chen
The present study aimed to investigate whether non-culprit coronary lesions (NCCLs) in young patients (<45 years) who underwent percutaneous coronary intervention (PCI) with stents have higher rates of atherosclerotic progression than older patients. Eight hundred and forty-eight consecutive patients who underwent successful PCI with stents and second coronary angiography in a single center from January 7, 2008 to May 7, 2013 were enrolled. NCCL progression was assessed using three-dimensional quantitative coronary angiography and was defined as ≥ 10% diameter reduction of preexisting stenoses of ≥ 50%, ≥ 30% diameter reduction of <50% stenoses, development of a new stenosis of ≥ 30% in a previously normal segment, or progression to total occlusion...
June 2015: International Journal of Cardiovascular Imaging
Huifeng Yun, Monika M Safford, Todd M Brown, Michael E Farkouh, Shia Kent, Pradeep Sharma, Meredith Kilgore, Vera Bittner, Robert S Rosenson, Elizabeth Delzell, Paul Muntner, Emily B Levitan
BACKGROUND: Patients with coronary heart disease are recommended to use statins following hospital discharge. Acute myocardial infarction (AMI) is a common complication of hospitalization, but the use of statins following discharge among patients who were not initially hospitalized for AMI has not been assessed adequately. METHODS AND RESULTS: Using the Medicare 5% national random sample, we determined statin use among beneficiaries who were hospitalized and who had a secondary discharge diagnosis of AMI and among beneficiaries who had a primary discharge diagnosis of AMI, coronary artery bypass grafting, or percutaneous coronary intervention in 2007-2009...
February 2015: Journal of the American Heart Association
Oleg Gaisenok, Sergey Martsevich, Svetlana Tripkosh, Yulia Lukina
OBJECTIVE: The aim of this study was to analyze the quality of lipid-lowering therapy in a cohort of patients with cardiovascular disease enrolled in a Moscow-based registry, and to analyze the factors affecting the regularity of statin administration in this patient category. METHODS: The present study included all patients who successively sought medical advice in the Preventive Pharmacotherapy Department of the Ministry of Healthcare of the Russian Federation between May 1 and December 31, 2011 (n=274)...
February 2015: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
L J Anderson, R S Taylor
INTRODUCTION: Overviews are a new approach to summarising evidence and synthesising results from related systematic reviews. OBJECTIVES: To conduct an overview of Cochrane systematic reviews to provide a contemporary review of the evidence for cardiac rehabilitation (CR), identify opportunities for merging or splitting existing Cochrane reviews, and identify current evidence gaps to inform new review titles. METHODS: The Cochrane Database of Systematic Reviews was searched to identify reviews that address the objectives of this overview...
December 15, 2014: International Journal of Cardiology
Luísa Lopes-Conceição, Marta Pereira, Carla Araújo, Olga Laszczýnska, Nuno Lunet, Ana Azevedo
INTRODUCTION AND OBJECTIVES: Reperfusion and revascularization therapies play an important role in the management of coronary heart disease and have contributed to decreases in case fatality rates. We aimed to describe the use of these therapies for the treatment of acute coronary syndrome (ACS) patients over time in Portugal. METHODS: PubMed was searched in July 2012. The proportion of patients treated with fibrinolysis, primary percutaneous coronary intervention (PCI), any PCI and coronary artery bypass grafting (CABG) was described according to type of ACS: STEMI (≥90% patients with ST-segment elevation or Q-wave myocardial infarction), NSTE-ACS (≥90% patients with non-ST-segment elevation ACS) and mixed ACS (all others)...
November 2014: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
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