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Lawrence Lenke

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https://www.readbyqxmd.com/read/29191095/male-sex-may-not-be-associated-with-worse-outcomes-in-primary-all-posterior-adult-spinal-deformity-surgery-a-multicenter-analysis
#1
David B Bumpass, Lawrence G Lenke, Jeffrey L Gum, Christopher I Shaffrey, Justin S Smith, Christopher P Ames, Shay Bess, Brian J Neuman, Eric Klineberg, Gregory M Mundis, Frank Schwab, Virginie Lafage, Han Jo Kim, Douglas C Burton, Khaled M Kebaish, Richard Hostin, Renaud Lafage, Michael P Kelly
OBJECTIVE Adolescent spine deformity studies have shown that male patients require longer surgery and have greater estimated blood loss (EBL) and complications compared with female patients. No studies exist to support this relationship in adult spinal deformity (ASD). The purpose of this study was to investigate associations between sex and complications, deformity correction, and health-related quality of life (HRQOL) in patients with ASD. It was hypothesized that male ASD patients would have greater EBL, longer surgery, and more complications than female ASD patients...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29171797/health-related-quality-of-life-outcomes-in-complex-adult-spinal-deformity-surgery
#2
Max S Riley, Keith H Bridwell, Lawrence G Lenke, Jonathan Dalton, Michael P Kelly
OBJECTIVE Significant health-related quality of life (HRQOL) benefits have been observed for patients undergoing primary and revision adult spinal deformity (ASD) surgery. The purpose of this study was to report changes in HRQOL measures in a consecutive series of patients undergoing complex spinal reconstructive surgery, using Scoli-RISK-1 (SR-1) inclusion criteria. METHODS This was a single-center, retrospective cohort study. The SR-1 inclusion criteria were used to define patients with complex ASD treated between June 1, 2009, and June 1, 2011...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29135883/an-analysis-of-the-incidence-and-outcomes-of-major-vs-minor-neurological-decline-after-complex-adult-spinal-deformity-surgery-a-sub-analysis-of-scoli-risk-1-study
#3
So Kato, Michael G Fehlings, Stephen J Lewis, Lawrence G Lenke, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé, Sigurd H Berven
STUDY DESIGN: A sub-analysis from a prospective, multicenter, international cohort study in 15 sites (Scoli-RISK-1). OBJECTIVE: To report detailed information regarding the severity of neurological decline related to complex adult spine deformity (ASD) surgery and to examine outcomes based on severity. SUMMARY OF BACKGROUND DATA: The basis of post-operative neurological decline after ASD surgeries can occur due to nerve root(s) or spinal cord dysfunction...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29057344/utilization-of-vertebroplasty-and-kyphoplasty-procedures-throughout-the-united-states-over-a-recent-decade-an-analysis-of-the-nationwide-inpatient-sample
#4
Joseph L Laratta, Jamal N Shillingford, Joseph M Lombardi, John D Mueller, Hemant Reddy, Comron Saifi, Charla R Fischer, Steven C Ludwig, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Given the increasing societal focus on health care utilization and value-based care, it is essential to understand the demographic and economic data surrounding percutaneous vertebral augmentation procedures performed in the United States. Double-blinded prospective randomized controlled trials have shown no benefit to the use of vertebroplasty over a sham procedure in the treatment of vertebral fractures. Contrastingly, kyphoplasty may be beneficial when appropriately indicated...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28965445/temporary-occipital-fixation-in-young-children-with-severe-cervical-thoracic-spinal-deformity
#5
Brian J Kelley, Anas A Minkara, Peter D Angevine, Michael G Vitale, Lawrence G Lenke, Richard C E Anderson
OBJECTIVE The long-term effects of instrumentation and fusion of the occipital-cervical-thoracic spine on spinal growth in young children are poorly understood. To mitigate the effects of this surgery on the growing pediatric spine, the authors report a novel technique used in 4 children with severe cervical-thoracic instability. These patients underwent instrumentation from the occiput to the upper thoracic region for stabilization, but without bone graft at the craniovertebral junction (CVJ). Subsequent surgery was then performed to remove the occipital instrumentation, thereby allowing further growth and increased motion across the CVJ...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28922278/defining-the-critical-elements-for-the-most-common-procedures-in-spine-surgery-a-consensus-of-orthopaedic-and-neurosurgical-surgeons
#6
Joseph L Laratta, Samuel Cohen-Tanugi, Jamal N Shillingford, Joseph M Lombardi, Lawrence G Lenke, K Daniel Riew, Ronald A Lehman, Steven C Ludwig
STUDY DESIGN: Survey. OBJECTIVE: To define the critical elements of common spine surgeries. SUMMARY OF BACKGROUND DATA: Despite significant relevance to the field of spine surgery, the term "critical element" of surgery has not been clearly defined. Every surgical procedure involves numerous steps, each with its own potential for complications and harm to the patient. Despite its crucial role in surgical training, billing, and the ethicality of concurrent surgery, the term "critical element" of surgery has not been defined...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28816826/tissue-engineered-bone-differentiated-from-human-adipose-derived-stem-cells-inhibit-posterolateral-fusion-in-an-athymic-rat-model
#7
Comron Saifi, Jonahtan Bernhard, Jamal N Shillingford, Petros Petridis, Samuel Robinson, X Edward Guo, Mark Weidenbaum, Ronald A Lehman, Howard S An, Lawrence G Lenke, Gordana Vunjak-Novakovic, Joseph L Laratta
STUDY DESIGN: Biological augmentation spinal arthrodesis trial in athymic rats OBJECTIVE.: To assess the efficacy of tissue-engineered bone to promote L4-L5 intertransverse process fusion in an athymic rat model. SUMMARY OF BACKGROUND DATA: Each year in the United States, over 400,000 spinal fusion surgeries are performed requiring bone graft. The current gold standard for posterolateral lumbar fusion is autogenous iliac crest bone graft (ICBG), but the harvesting of ICBG is associated with increased operative time and significant complications...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28780621/an-international-consensus-on-the-appropriate-evaluation-and-treatment-for-adults-with-spinal-deformity
#8
Sigurd H Berven, Steven J Kamper, Niccole M Germscheid, Benny Dahl, Christopher I Shaffrey, Lawrence G Lenke, Stephen J Lewis, Kenneth M Cheung, Ahmet Alanay, Manabu Ito, David W Polly, Yong Qiu, Marinus de Kleuver
PURPOSE: Evaluation and surgical management for adult spinal deformity (ASD) patients varies between health care providers. The purpose of this study is to identify appropriateness of specific approaches and management strategies for the treatment of ASD. METHODS: From January to July 2015, the AOSpine Knowledge Deformity Forum performed a modified Delphi survey where 53 experienced deformity surgeons from 24 countries, rated the appropriateness of management strategies for multiple ASD clinical scenarios...
August 5, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28660112/vertebral-column-resection-for-rigid-spinal-deformity
#9
REVIEW
Comron Saifi, Joseph L Laratta, Petros Petridis, Jamal N Shillingford, Ronald A Lehman, Lawrence G Lenke
STUDY DESIGN: Broad narrative review. OBJECTIVE: To review the evolution, operative technique, outcomes, and complications associated with posterior vertebral column resection. METHODS: A literature review of posterior vertebral column resection was performed. The authors' surgical technique is outlined in detail. The authors' experience and the literature regarding vertebral column resection are discussed at length. RESULTS: Treatment of severe, rigid coronal and/or sagittal malalignment with posterior vertebral column resection results in approximately 50-70% correction depending on the type of deformity...
May 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28660108/distal-fusion-level-selection-in-scheuermann-s-kyphosis-a-comparison-of-lordotic-disc-segment-versus-the-sagittal-stable-vertebrae
#10
Han Jo Kim, Venu Nemani, Oheneba Boachie-Adjei, Matthew E Cunningham, Justin A Iorio, Kevin O'Neill, Brian J Neuman, Lawrence G Lenke
STUDY DESIGN: Retrospective study. OBJECTIVE: To compare 2 methods of selecting the lowest instrumented vertebra (LIV) on the rates of revision surgery for distal junctional kyphosis (DJK) following treatment for Scheuermann's kyphosis (SK). METHODS: A retrospective review of patients who have undergone surgical treatment for SK was performed. Forty-four patients were divided into 2 groups based on intervention: Group 1 (n = 26) included patients who had an LIV distal to or at the sagittal stable vertebrae (SSV), and Group 2 (n = 18) included patients who had an LIV proximal to the SSV...
May 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28589303/three-types-of-sagittal-alignment-regarding-compensation-in-asymptomatic-adults-the-contribution-of-the-spine-and-lower-limbs
#11
Hongda Bao, Renaud Lafage, Barthelemy Liabaud, Jonathan Elysée, Bassel G Diebo, Gregory Poorman, Cyrus Jalai, Peter Passias, Aaron Buckland, Shay Bess, Thomas Errico, Lawrence G Lenke, Munish Gupta, Han Jo Kim, Frank Schwab, Virginie Lafage
PURPOSE: A comprehensive understanding of normative sagittal profile is necessary for adult spinal deformity. Roussouly described four sagittal alignment types based on sacral slope, lumbar lordosis, and location of lumbar apex. However, the lower limb, a newly described component of spinal malalignment compensation, is missing from this classification. This study aims to propose a full-body sagittal profile classification in an asymptomatic population based on full-body imaging. METHODS: This is a retrospective analysis of a prospective single-center study of 116 asymptomatic volunteers...
June 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28475019/retrospective-analysis-underestimates-neurological-deficits-in-complex-spinal-deformity-surgery-a-scoli-risk-1-study
#12
MULTICENTER STUDY
Michael P Kelly, Lawrence G Lenke, Jakub Godzik, Ferran Pellise, Christopher I Shaffrey, Justin S Smith, Stephen J Lewis, Christopher P Ames, Leah Y Carreon, Michael G Fehlings, Frank Schwab, Adam L Shimer
OBJECTIVE The authors conducted a study to compare neurological deficit rates associated with complex adult spinal deformity (ASD) surgery when recorded in retrospective and prospective studies. Retrospective studies may underreport neurological deficits due to selection, detection, and recall biases. Prospective studies are expensive and more difficult to perform, but they likely provide more accurate estimates of new neurological deficit rates. METHODS New neurological deficits were recorded in a prospective study of complex ASD surgeries (pSR1) with a defined outcomes measure (decrement in American Spinal Injury Association lower-extremity motor score) for neurological deficits...
July 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28441310/a-dose-response-curve-for-a-gram-negative-spinal-implant-infection-model-in-rabbits
#13
Joseph L Laratta, Jamal N Shillingford, Nathan Hardy, Ronald A Lehman, Lawrence G Lenke, K Daniel Riew
STUDY DESIGN: A randomized complete block animal spinal implant infection model with internal control. OBJECTIVE: The aim of this study was to develop a spinal implant animal infection model to simulate postoperative gram-negative wound infection. SUMMARY OF BACKGROUND DATA: Implant-associated surgical site infections (SSIs) remain a dreaded complication of spinal surgery. Currently, over 30% of all spine SSIs are secondary to gram-negative bacteria...
November 1, 2017: Spine
https://www.readbyqxmd.com/read/28399544/intrawound-tobramycin-powder-eradicates-surgical-wound-contamination-an-in-vivo-rabbit-study
#14
Joseph L Laratta, Jamal N Shillingford, Nathan Hardy, Joseph M Lombardi, Comron Saifi, Alexander Romanov, Lawrence G Lenke, Ronald A Lehman, K Daniel Riew
STUDY DESIGN: Therapeutic anti-infective trial in rabbitsOBJECTIVE.: The purpose of the present study was to assess the efficacy of intrawound tobramycin powder in terms of eradicating a known bacterial contamination in an Escherichia coli infected rabbit spinal implantation model. SUMMARY OF BACKGROUND DATA: Implant-associated surgical site infections (SSI) remain a dreaded complication of spinal surgery. Currently, over 30% of all spine SSIs are secondary to gram-negative bacteria...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28350940/recent-and-emerging-advances-in-spinal-deformity
#15
REVIEW
Justin S Smith, Christopher I Shaffrey, Shay Bess, Mohammed F Shamji, Darrel Brodke, Lawrence G Lenke, Michael G Fehlings, Virginie Lafage, Frank Schwab, Alexander R Vaccaro, Christopher P Ames
BACKGROUND: Over the last several decades, significant advances have occurred in the assessment and management of spinal deformity. OBJECTIVE: The primary focus of this narrative review is on recent advances in adult thoracic, thoracolumbar, and lumbar deformities, with additional discussions of advances in cervical deformity and pediatric deformity. METHODS: A review of recent literature was conducted. RESULTS: Advances in adult thoracic, thoracolumbar, and lumbar deformities reviewed include the growing applications of stereoradiography, development of new radiographic measures and improved understanding of radiographic alignment objectives, increasingly sophisticated tools for radiographic analysis, strategies to reduce the occurrence of common complications, and advances in minimally invasive techniques...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28323715/the-safety-and-strength-of-a-novel-medial-partial-nonthreaded-pedicle-screw-a-cadaveric-and-biomechanical-investigation
#16
Mun Keong Kwan, Chris Yin Wei Chan, Lim Beng Saw, Shanmugam Rukmanikanthan, Lawrence G Lenke
STUDY DESIGN: Cadaveric and biomechanical study. OBJECTIVE: The aim of this study was to assess the safety and pullout strength of medial, partial nonthreaded thoracic pedicle screws compared with conventional screws. SUMMARY OF BACKGROUND DATA: The perforation rate of the pedicle screws has been reported as high as 41%. Nerve injury and irritation can result from the compression of malpositioned screw on neural structures. METHODS: Ten fresh cadavers were studied...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28259266/predictors-of-health-related-quality-of-life-after-complex-adult-spinal-deformity-surgery-a-scoli-risk-1-secondary-analysis
#17
Leah Y Carreon, Steven D Glassman, Christopher I Shaffrey, Michael G Fehlings, Benny Dahl, Christopher P Ames, Yukihiro Matsuyama, Yong Qiu, Hossein Mehdian, Kenneth M C Cheung, Frank J Schwab, Ferran Pellisé, Khaled M Kebaish, Lawrence G Lenke
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To identify variables that predict 2-year Short Form-36 Physical Composite Summary Score (SF-36PCS) and the Scoliosis Research Society-22R (SRS22-R) Total score after surgery for complex adult spinal deformity. SUMMARY OF BACKGROUND DATA: Increasingly, treatment effectiveness is assessed by the extent to which the procedure improves a patient's health-related quality of life (HRQOL). This is especially true in patients with complex adult spinal deformity...
March 2017: Spine Deformity
https://www.readbyqxmd.com/read/28207660/predictors-of-distal-adding-on-in-thoracic-major-curves-with-ar-lumbar-modifiers
#18
Joshua S Murphy, Vidyadhar V Upasani, Burt Yaszay, Tracey P Bastrom, Carrie E Bartley, Amer Samdani, Lawrence G Lenke, Peter O Newton
STUDY DESIGN: Retrospective review of prospectively collected data. OBJECTIVE: To determine whether the last substantially touched vertebra (LSTV) is a valid lowest instrumented vertebra (LIV) for both Lenke 1 and 2 curve patterns with AR lumbar modifiers, and to identify preoperative risk factors of distal adding-on. SUMMARY OF BACKGROUND DATA: Previous studies have recommended selecting the LSTV as the LIV for Lenke 1AR curves (main thoracic curve with A lumbar modifier and L4 tilt to the right (thoracic overhang/King type IV curve)...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/27927552/multicenter-comparison-of-3d-spinal-measurements-using-surface-topography-with-those-from-conventional-radiography
#19
Patrick Knott, Peter Sturm, Baron Lonner, Patrick Cahill, Marcel Betsch, Richard McCarthy, Michael Kelly, Lawrence Lenke, Randal Betz
INTRODUCTION: In pediatric spinal deformity the gold standard for curve surveillance remains standing full-column radiographs, but repeated exposure to ionizing radiation motivates us to look for nonradiographic solutions. This study tests a modern system of surface topography (ST) to determine whether it is reliable and reproducible. METHODS: Patients from 6 pediatric spinal deformity clinics were recruited for enrollment. Inclusion criteria were age 8-18; diagnosis of scoliosis measuring ≥10 and <50 degrees or increased kyphosis of ≥45 degrees...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927545/does-planned-staging-for-posterior-only-vertebral-column-resections-in-spinal-deformity-surgery-increase-perioperative-complications
#20
Jeffrey L Gum, Lawrence G Lenke, David Bumpass, Johnny Zhao, Patrick Sugrue, Isaac Karikari, Ra'Kerry Rahman, Leah Y Carreon
STUDY DESIGN: Propensity-matched case control. OBJECTIVES: To compare the perioperative complication rate between single- and two-stage posterior-only VCRs (2-pVCR). SUMMARY OF BACKGROUND DATA: A vertebral column resection (VCR) for severe spinal deformity is a technically challenging and lengthy procedure with a potentially high complication rate. Planned staging has an advantage of distributing operative time into 2 smaller, more manageable, intervals...
March 2016: Spine Deformity
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