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https://www.readbyqxmd.com/read/29774412/hybrid-constructs-pedicle-screw-with-apical-sublaminar-bands-versus-pedicle-screws-only-for-surgical-correction-of-adolescent-idiopathic-scoliosis
#1
Matteo Palmisani, Eugenio Dema, Stefano Cervellati, Rosa Palmisani
PURPOSE: To compare the 2-year minimum postoperative results of posterior correction and spinal arthrodesis using translational correction with hybrid (sublaminar bands on concave side and pedicle screw) constructs versus correction with intermediate density pedicle screw-only constructs in the treatment of AIS (Lenke 1). METHODS: A total of 37 patients with AIS at single institutions who underwent posterior spinal arthrodesis pedicle screw with sublaminar bands at the apex (19 patients) (Group A) or pedicle screw-only (18) constructs (Group B) were selected and matched according to similar age at surgery 13...
May 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29762340/external-validation-of-the-adult-spinal-deformity-asd-frailty-index-asd-fi-in-the-scoli-risk-1-patient-database
#2
Emily K Miller, Lawrence G Lenke, Brian J Neuman, Daniel M Sciubba, Khaled M Kebaish, Justin S Smith, Yong Qiu, Benny T Dahl, Ferran Pellisé, Yukihiro Matsuyama, Leah Y Carreon, Michael G Fehlings, Kenneth M Cheung, Stephen Lewis, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Hossein Mehdian, Shay Bess, Christopher I Shaffrey, Christopher P Ames
STUDY DESIGN: Analysis of a prospective multicenter database. OBJECTIVE: To assess the ability of the recently created Adult Spinal Deformity (ASD) Frailty Index (ASD-FI) to predict odds of major complications and length of hospital stay for patients who had more severe preoperative deformity and underwent more invasive ASD surgery compared with patients in the database used to create the index. SUMMARY OF BACKGROUND DATA: Accurate preoperative estimates of risk are necessary given the high complication rates currently associated with ASD surgery...
May 14, 2018: Spine
https://www.readbyqxmd.com/read/29755969/evaluation-of-fluorine-18-labeled-%C3%AE-1-i-n-telopeptide-analogs-as-substrate-based-radiotracers-for-pet-imaging-of-melanoma-associated-lysyl-oxidase
#3
Manuela Kuchar, Christin Neuber, Birgit Belter, Ralf Bergmann, Jens Lenk, Robert Wodtke, Torsten Kniess, Jörg Steinbach, Jens Pietzsch, Reik Löser
Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of tumors. Considering their function in matrix remodeling, malignant melanoma appears as particularly interesting neoplasia in this respect. For the development of radiotracers that enable PET imaging of the melanoma-associated lysyl oxidase activity, substrates derived from the type I collagen α1 N-telopeptide were labeled with fluorine-18 using N -succinimidyl 4-[18 F]fluorobenzoate ([18 F]SFB) as prosthetic reagent...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29748903/sagittal-classification-in-adolescent-idiopathic-scoliosis-original-description-and-therapeutic-implications
#4
K Abelin-Genevois, D Sassi, S Verdun, P Roussouly
INTRODUCTION: Surgical treatment of AIS aims to correct the coronal and sagittal alignment of the spine. The global alignment of the spine may be normalized through reciprocal changes between the fused spine and adjacent segments. We propose a new classification system describing the specific sagittal patterns induced by AIS to define reproducible guidelines for the surgical strategy. METHODS: We analyzed 100 consecutive AIS patients aged between 12 and 18 years candidate for spinal fusion...
May 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29735133/optimal-lowest-instrumented-vertebra-for-thoracic-adolescent-idiopathic-scoliosis
#5
Charla R Fischer, Lawrence G Lenke, Keith H Bridwell, Oheneba Boachie-Adjei, Munish Gupta, Yongjung J Kim
STUDY DESIGN: Retrospective cohort chart review. OBJECTIVE: To determine the optimal lowest instrumented vertebra (LIV) following posterior segmental spinal instrumented fusion (PSSIF) of thoracic adolescent idiopathic scoliosis (AIS) with LIV at L2 or above. SUMMARY OF BACKGROUND DATA: Few studies evaluate the optimal LIV based on rotation or center sacral vertical line (CSVL). METHODS: A radiographic assessment of 544 thoracic major AIS patients (average age 14...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735132/the-lumbar-gap-measurement-in-lenke-1-4c-curves
#6
Hong Zhang, B Stephens Richards, Daniel J Sucato, Chan-Hee Jo, Dong Tran, Linfeng Wang
STUDY DESIGN: Retrospective review. OBJECTIVES: To assess whether the lumbar gap (LG) measurement, which is the distance between the center sacral vertical line and the concave edge of the apical vertebra of the lumbar curve, would be a useful tool to predict the need for lumbar curve fusion in the Lenke 1-4C curves. SUMMARY OF BACKGROUND DATA: The current treatment guidelines of selective thoracic fusion in the Lenke 1-4C curves are not routinely accepted...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735131/anterior-spinal-fusion-and-posterior-spinal-fusion-both-effectively-treat-lenke-type-5-curves-in-adolescent-idiopathic-scoliosis-a-multicenter-study
#7
Courtney O'Donnell, Nicole Michael, X Pan, John Emans, Sumeet Garg, Mark Erickson
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: Retrospective comparison of radiographic and clinical outcomes between anterior spinal fusion (ASF) and posterior spinal fusion (PSF) in surgical treatment of Lenke 5 curves. SUMMARY OF BACKGROUND DATA: ASF and PSF are used for treatment of Lenke 5 curves in patients with adolescent idiopathic scoliosis (AIS). Currently, no consensus exists for optimal surgical treatment of Lenke 5 curves...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29733900/radiological-and-clinical-outcome-of-selective-thoracic-fusion-stf-for-lenke-1c-and-2c-adolescent-idiopathic-scoliosis-ais-patients-with-a-minimum-follow-up-of-2-years
#8
Mun Keong Kwan, Chee Kidd Chiu, Pheng Hian Tan, Xue Han Chian, Xin Yi Ler, Yun Hui Ng, Sherwin Johan Ng, Saw Huan Goh, Chris Yin Wei Chan
BACKGROUND CONTEXT: In Lenke 1C and 2C curves, the choice between selective thoracic fusion (STF) versus non-selective thoracic fusion (NSTF) as the optimal surgical treatment is controversial. OBJECTIVE: To assess the radiological and clinical outcome of patients with Lenke 1C/2C curves treated with STF. STUDY DESIGN: Retrospective study PATIENT SAMPLE: 44 METHODS: 44 Lenke 1C/2C AIS patients curves who underwent STF were reviewed. Radiological parameters and SRS-22r scores were assessed preoperatively, postoperatively and on final follow-up...
May 4, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29726791/postoperative-changes-in-sagittal-spinopelvic-alignment-in-sitting-position-in-adolescents-with-idiopathic-thoracic-scoliosis-treated-with-posterior-fusion-an-initial-analysis
#9
Weiguo Zhu, Zhen Liu, Shifu Sha, Jing Guo, Hongda Bao, Leilei Xu, Yong Qiu, Zezhang Zhu
OBJECTIVE Previous studies have reported spinal straightening and pelvic retroversion when changing from erect to sitting posture in patients with adolescent idiopathic scoliosis (AIS), which were thought to be related to low-back pain after sitting for long periods. However, the sitting sagittal alignment after posterior spinal fusion has not been evaluated. This study aims to assess the influence of posterior fusion surgery upon sitting sagittal spinopelvic alignment in adolescents with idiopathic thoracic curves (thoracic AIS [T-AIS])...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29709744/radiographic-fusion-grade-does-not-impact-health-related-quality-of-life-in-the-absence-of-instrumentation-failure-for-patients-undergoing-posterior-instrumented-fusion-for-adult-spinal-deformity
#10
Tamir Ailon, D Koho Hamilton, Erik Klineberg, Alan H Daniels, Virginie Lafage, Shay Bess, Douglas C Burton, Munish Gupta, Frank Schwab, Christopher P Ames, Justin S Smith, Christopher I Shaffrey, Robert A Hart
BACKGROUND: Pseudarthrosis and rod fracture (RF) remain significant concerns following fusions for adult spinal deformity (ASD). While a radiographic system of fusion grade has been proposed, the correlation between fusion grade and Health Related Quality of Life measures (HRQoL) is not known. METHODS: In a retrospective review of a prospectively collected clinical database, patients that underwent ≥ 5 level posterior instrumented arthrodesis for ASD were evaluated...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707058/t1-weighted-mr-imaging-of-bone-marrow-pattern-in-children-with-adolescent-idiopathic-scoliosis-a-preliminary-study
#11
S I Shiran, L Shabtai, L Ben-Sira, D Ovadia, S Wientroub
Purpose: Distinct normal physiological patterns of fat conversion in vertebrae were described both for children and adults. Our aim was to evaluate the T1-weighted bone marrow pattern of the vertebral bodies in various sites along the scoliotic spine of children with adolescent idiopathic scoliosis (AIS). Methods: We retrospectively evaluated spine MRI studies of children with AIS. Scoliosis radiographs were assessed for type of curvature according to the Lenke classification...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29702308/unilateral-veral-pedicle-screw-fixation-combined-with-transforaminal-lumbar-interbody-fusion-rsus-bilatefor-the-treatment-of-low-lumbar-degenerative-disc-diseases-analysis-of-clinical-and-radiographic-results
#12
De-Jian Chen, Cong Yao, Quanwei Song, Benyu Tang, Xuqiang Liu, Bin Zhang, Min Dai, Tao Nie, Zongmiao Wan
OBJECTIVE: Our objective was to compare the clinical and radiographic results of unilateral pedicle screw fixation (UPSF) and bilateral pedicle screw fixation (BPSF) after unilateral transforaminal lumbar interbody fusion (TLIF) for the treatment of lumbar degenerative disc diseases (DDD). MATERIALS AND METHODS: 63 patients who underwent UPSF or BPSF combined with unilateral TLIF at L4-L5 or L5-S1 were included in our hospital from 2014-2016. The perioperative outcomes and radiographic results were recorded at preoperative and postoperative follow-up...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29694667/change-of-sagittal-spinopelvic-parameters-after-selective-and-non-selective-fusion-in-lenke-type-1-adolescent-idiopathic-scoliosis-patients
#13
Deniz Kargin, Özgür İsmail Türk, Akif Albayrak, Avni İlhan Bayhan, Mehmet Akif Kaygusuz
AIM: Lenke Type 1, the main thoracic curve type, is the most common spinal curve pattern in adolescent idiopathic scoliosis (AIS). The aim of this study was to compare the postoperative changes of both sagittal spinal and spinopelvic parameters in patients with Lenke Type 1 AIS who underwent selective and non-selective fusion surgery. MATERIAL AND METHODS: We conducted a retrospective study among 53 Lenke Type 1 AIS patients who underwent corrective surgery at our centre between 2006 and 2012...
April 9, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29688489/protective-role-of-the-lipid-phosphatase-fig4-in-the-adult-nervous-system
#14
Yevgeniya A Mironova, Jing-Ping Lin, Ashley Kalinski, Lucas Huffman, Guy M Lenk, Leif A Havton, Miriam H Meisler, Roman J Giger
The signaling lipid phosphatidylinositol 3,5-bisphosphate, PI(3,5)P2, functions in vesicular trafficking through the endo-lysosomal compartment. Cellular levels of PI(3,5)P2 are regulated by an enzyme complex comprised of the kinase PIKFYVE, the phosphatase FIG4, and the scaffold protein VAC14. Mutations of human FIG4 cause inherited disorders including Charcot-Marie-Tooth disease type 4J, polymicrogyria with epilepsy, and Yunis-Varón syndrome. Constitutive Fig4-/- mice exhibit intention tremor, spongiform degeneration of neural tissue, hypomyelination, and juvenile lethality...
April 24, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29685405/high-prevalence-of-greater-trochanteric-pain-syndrome-among-patients-presenting-to-spine-clinic-for-evaluation-of-degenerative-lumbar-pathologies
#15
Lee A Tan, Barlas Benkli, Alexander Tuchman, Xudong J Li, Natasha N Desai, Thomas S Bottiglieri, Jeffrey Pavel, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Greater trochanteric pain syndrome (GTPS) is a relatively common diagnosis among the general population. OBJECTIVE: We aim to determine the prevalence of GTPS among patients who presented to the spine clinic. METHODS: Medical records of patients who were evaluated in the spine clinic were reviewed over a 12-month period (4/1/2016 to 3/31/2017). Patient demographics, presenting symptomatology, physical examination findings, presence or absence of GTPS, medical imaging findings, and interventions were recorded analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29672421/human-versus-robot-a-propensity-matched-analysis-of-the-accuracy-of-free-hand-versus-robotic-guidance-for-placement-of-s2-alar-iliac-s2ai-screws
#16
Jamal N Shillingford, Joseph L Laratta, Paul J Park, Joseph M Lombardi, Alexander Tuchman, Comron S Saifi, Ronald A Lehman, Lawrence G Lenke
STUDY DESIGN: Retrospective matched cohort analysis. OBJECTIVE: To compare the accuracy of S2 alar-iliac (S2AI) screw placement by robotic guidance versus free hand technique. SUMMARY OF BACKGROUND DATA: Spinopelvic fixation utilizing S2AI screws provides optimal fixation across the lumbosacral junction allowing for solid fusion, especially in long segment fusion constructs. Traditionally, S2AI screw placement has required fluoroscopic guidance for accurate screw placement...
April 18, 2018: Spine
https://www.readbyqxmd.com/read/29666920/-unusual-coloboma-of-the-optic-disc
#17
J Lenk, L E Pillunat, E Matthé
A twelve-year old girl presented herself for a routine ophthalmologic examination in our clinic. Best-corrected visual acuity (BCVA) was 1.0 on both eyes. On funduscopic examination we saw a yellow round structure inferior to the optic nerve head. In optical coherence tomography (OCT) examination the structure showed cupping and opening of the Bruch membrane and retinal pigment epithelium (RPE). Visual field testing revealed an absolute scotoma right in the area were the abnormal coloboma was localized. We diagnosed a pseudo-doubling of the optic disk, which is a rare condition with just a few reports about it in the literature...
April 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29664864/managing-expectations-in-three-column-spinal-osteotomy-surgery-motor-deficits-are-more-common-commentary-on-an-article-by-lawrence-g-lenke-md-et-al-lower-extremity-motor-function-following-complex-adult-spinal-deformity-surgery-two-year-follow-up-in-the-scoli
#18
https://www.readbyqxmd.com/read/29664852/lower-extremity-motor-function-following-complex-adult-spinal-deformity-surgery-two-year-follow-up-in-the-scoli-risk-1-prospective-multicenter-international-study
#19
Lawrence G Lenke, Christopher I Shaffrey, Leah Y Carreon, Kenneth M C Cheung, Benny T Dahl, Michael G Fehlings, Christopher P Ames, Oheneba Boachie-Adjei, Mark B Dekutoski, Khaled M Kebaish, Stephen J Lewis, Yukihiro Matsuyama, Hossein Mehdian, Ferran Pellisé, Yong Qiu, Frank J Schwab
BACKGROUND: The reported neurologic complication rate following surgery for complex adult spinal deformity (ASD) is variable due to several factors. Most series have been retrospective with heterogeneous patient populations and use of nonuniform neurologic assessments. The aim of this study was to prospectively document lower extremity motor function by means of the American Spinal Injury Association (ASIA) lower extremity motor score (LEMS) before and through 2 years after surgical correction of complex ASD...
April 18, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29662739/decompression-in-adult-lumbar-deformity-surgery-is-associated-with-increased-perioperative-complications-but-favorable-long-term-outcomes
#20
Isaac O Karikari, Keith H Bridwell, Aladine A Elsamadicy, Lawrence G Lenke, Patrick Sugrue, David Bumpass, Azeem Ahmad, Jeffrey Gum
Study Design: Retrospective cohort study. Objectives: To analyze the impact of performing a formal decompression in patients with adult lumbar scoliosis with symptomatic spinal stenosis on perioperative complications and long-term outcomes. Methods: Adult patients undergoing at least 5 levels of fusion to the sacrum with iliac fixation from 2002 to 2008 who had a minimum 5-year follow-up at one institution were studied. Patients who had 3-column osteotomy were excluded from the study...
April 2018: Global Spine Journal
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