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Fecal calprotectin in celiac disease

Seema Rajani, Hien Q Huynh, Leanne Shirton, Cheryl Kluthe, Donald Spady, Connie Prosser, Jon Meddings, Gwen R Rempel, Rabindranath Persad, Justine M Turner
Background. The European Society for Pediatric Gastroenterology, Hepatology and Nutrition endorses serological diagnosis (SD) for pediatric celiac disease (CD). The objective of this study was to pilot SD and to prospectively evaluate gastrointestinal permeability and mucosal inflammation at diagnosis and after one year on the gluten-free diet (GFD). We hypothesized that SD would be associated with similar short term outcomes as ED. Method. Children, 3-17 years of age, referred for possible CD were eligible for SD given aTTG level ≥200 U/mL, confirmed by repeat aTTG and HLA haplotypes...
2016: Canadian Journal of Gastroenterology & Hepatology
Dan Carter, Eytan Bardan, Estela Derazne, Dorit Tzur, Benjamin Avidan
BACKGROUND AND AIMS: The etiology of iron deficiency (ID) without anemia in young men is unclear, and there are no evidence-based recommendations for the required gastrointestinal (GI) evaluation. The aims of this study were to examine the incidence of significant GI pathology and the development of anemia during the follow-up of young men presenting with ID, but without anemia. METHODS: All young men (18-30 years) who served in the Israel Defense Forces during the years 2005-2013 and had at least a single laboratory test indicative of ID without anemia were followed until the diagnosis of significant GI pathology or discharge from military service...
October 2016: European Journal of Gastroenterology & Hepatology
Massimo Martinelli, Caterina Strisciuglio, Annalisa Alessandrella, Francesca Rossi, Renata Auricchio, Natascia Campostrini, Domenico Girelli, Bruno Nobili, Annamaria Staiano, Silverio Perrotta, Erasmo Miele
BACKGROUND AND AIMS: We sought to correlate hepcidin levels in inflammatory bowel disease [IBD] children with disease activity, inflammatory markers, and iron load test [ILT] and to compare IBD patients with coeliac and healthy patients. METHODS: Between December 2012 and June 2013, 145 subjects [50 IBD patients, 45 coeliac patients and 50 healthy controls] were included in the study. All patients underwent the following examinations: blood count, iron status, erythropoiesis parameters, serum hepcidin, C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]...
May 2016: Journal of Crohn's & Colitis
M F Osipenko, m A Livzan, M I Skalinskaia, E A Lialiukova
AIM: To estimate the informative value of a noninvasive fecal (calprotectin) test in the differential diagnosis of bowel diseases. SUBJECTS AND METHODS: One hundred and forty-two patients who had visited their physicians with intestinal disorders (a change in stool frequency and patterns, abdominal pain) were examined in an open-label multicenter cross-sectional study. The examinees' mean age was 35 ± 2.43 years. Gender- and age-matched comparison groups consisted of healthy individuals and patients with irritable bowel syndrome...
2015: Terapevticheskiĭ Arkhiv
William D Chey, Jacob Kurlander, Shanti Eswaran
IMPORTANCE: Irritable bowel syndrome (IBS) affects 7% to 21% of the general population. It is a chronic condition that can substantially reduce quality of life and work productivity. OBJECTIVES: To summarize the existing evidence on epidemiology, pathophysiology, and diagnosis of IBS and to provide practical treatment recommendations for generalists and specialists according to the best available evidence. EVIDENCE REVIEW: A search of Ovid (MEDLINE) and Cochrane Database of Systematic Reviews was performed for literature from 2000 to December 2014 for the terms pathophysiology, etiology, pathogenesis, diagnosis, irritable bowel syndrome, and IBS...
March 3, 2015: JAMA: the Journal of the American Medical Association
Necati Balamtekın, Gökhan Baysoy, Nuray Uslu, Diclehan Orhan, Zuhal Akçören, Hasan Özen, Figen Gürakan, İnci Nur Saltik-Temızel, Aysel Yüce
BACKGROUND/AIMS: The aim of this study was to compare the fecal calprotectin concentration in children with newly diagnosed celiac disease, children with celiac disease strictly adhering to a gluten-free diet and healthy controls. We also tried to correlate the fecal calprotectin concentration with the clinical presentation, degree of neutrophilic infiltration and the severity of histopathological injury (Marsh grade) in the small bowel mucosa. MATERIAL AND METHODS: The study included three groups: children with untreated celiac disease, children with treated celiac disease, and healthy controls...
2012: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Gregory Juckett, Rupal Trivedi
Chronic diarrhea, defined as a decrease in stool consistency for more than four weeks, is a common but challenging clinical scenario. It can be divided into three basic categories: watery, fatty (malabsorption), and inflammatory. Watery diarrhea may be subdivided into osmotic, secretory, and functional types. Watery diarrhea includes irritable bowel syndrome, which is the most common cause of functional diarrhea. Another example of watery diarrhea is microscopic colitis, which is a secretory diarrhea affecting older persons...
November 15, 2011: American Family Physician
Vildan Ertekin, Mukadder Ayşe Selimoğlu, Ahmet Turgut, Nuri Bakan
GOALS: We aimed to determine fecal calprotectin (FC) concentration and its relation with histopathologic findings of children with celiac disease (CD) and to observe the probable alterations under gluten-free diet (GFD). BACKGROUND: As FC is regarded as a marker of inflammation in the gastrointestinal tract, we hypothesized that it might be increased in untreated CD. STUDY: The study included 29 newly diagnosed patients with CD (mean age: 6...
September 2010: Journal of Clinical Gastroenterology
F Cremonini, N J Talley
The management of patients with irritable bowel syndrome (IBS) is a frequent, yet challenging task in both primary care and gastroenterology practice. A diagnostic strategy guided by keen clinical judgment should focus on positive symptom criteria and on the absence of alarm symptoms. In younger patients lacking alarm features, invasive testing has a low-yield. The presence of food intolerance and underlying celiac disease should be excluded. The usefulness of fecal tests such as calprotectin and lactoferrin to exclude organic bowel disease is not adequately established...
October 2004: Minerva Medica
Antonio Carroccio, Giuseppe Iacono, Mario Cottone, Lidia Di Prima, Fabio Cartabellotta, Francesca Cavataio, Calogero Scalici, Giuseppe Montalto, Gaetana Di Fede, GiovamBattista Rini, Alberto Notarbartolo, Maurizio R Averna
BACKGROUND: Fecal calprotectin (FC) has been proposed as a marker of inflammatory bowel disease (IBD), but few studies have evaluated its usefulness in patients with chronic diarrhea of various causes. We evaluated the diagnostic accuracy of a FC assay in identifying "organic" causes of chronic diarrhea in consecutive adults and children. METHODS: We consecutively enrolled 70 adult patients (30 males, 40 females; median age, 35 years) and 50 children (20 males, 30 females; median age, 3...
June 2003: Clinical Chemistry
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