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Clinical Infectious Diseases

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https://www.readbyqxmd.com/read/29054902/chylous-ascites-in-a-patient-with-an-overlap-syndrome-a-surprising-response-to-rituximab
#1
Alexandra Daniel, Gianluca Bagnato, Edward Vital, Francesco Del Galdo
The authors present a case of a 51-year-old woman with clinical diagnosis of mixed connective tissue disease and overlap systemic lupus erythematosus features, with a 6-month history of progressive painless abdominal distension. On examination, evident signs of ascites were present. Both the abdominal-pelvic ultrasound and CT scan confirmed a large amount of ascites. A diagnostic paracentesis was performed, which revealed typical features of chylous ascites (CA). An extensive diagnostic work-up led by a multidisciplinary team was performed, excluding malignancy, cirrhosis, infectious, as well as cardiac and primary lymphatic causes...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054683/the-anthelminthic-drug-praziquantel-is-a-selective-agonist-of-the-sensory-transient-receptor-potential-melastatin-type-8-channel
#2
Ramona-Madalina Babes, Tudor Selescu, Dan Domocos, Alexandru Babes
Praziquantel is the most effective anthelminthic drug for the treatment of schistosomiasis, an infectious disease caused by the platyhelminth Schistosoma mansoni. While praziquantel is known to trigger calcium influx into schisostomes, followed by spastic paralysis of the worms and tegumental disruption, the mechanism of action of the drug is not completely understood. Although relatively well tolerated, praziquantel has been reported to cause mild adverse effects, including nausea, abdominal pain and headaches...
October 17, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29054443/development-of-an-xtag-multiplex-pcr-array-for-the-detection-of-four-avian-respiratory-viruses
#3
Feng Cong, Yujun Zhu, Xiangnan Liu, Xiuzhen Li, Meili Chen, Ren Huang, Pengju Guo
Acute respiratory tract infections are of paramount importance in the poultry industry. We developed an xTAG bead assay for the simultaneous detection and discrimination of avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The assay lacked nonspecific reactions with other common avian viruses and the limit of detection was 6.75 × 10(2)- 3.52 × 10(3)copies/μL. We examined 60 clinical specimens and found 18 positive for respiratory viruses...
October 17, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29053888/epidemiological-patterns-of-tick-borne-encephalitis-in-lithuania-and-clinical-features-in-adults-in-the-light-of-the-high-incidence-in-recent-years-a-retrospective-study
#4
Daiva Radzišauskienė, Kęstutis Žagminas, Loreta Ašoklienė, Arminas Jasionis, Rūta Mameniškienė, Arvydas Ambrozaitis, Ligita Jančorienė, Dalius Jatužis, Iveta Petraitytė, Evelina Mockienė
BACKGROUND: Lithuania is one of the countries with the highest incidence of TBE in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. METHODS: Surveillance data available on the website of the Center for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE. The retrospective study included 712 patients hospitalized in the Center for Infectious Diseases and the Center for Neurology of Vilnius University in the years 2005-2014...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053853/genome-sequence-analysis-of-a-distinctive-italian-infectious-bursal-disease-virus
#5
V Felice, G Franzo, E Catelli, A Di Francesco, M Bonci, M Cecchinato, G Mescolini, D Giovanardi, P Pesente, C Lupini
In a recent study, an emerging infectious bursal disease virus (IBDV) genotype (ITA) was detected in IBDV-live vaccinated broilers without clinical signs of infectious bursal disease (IBD). VP2 sequence analysis showed that strains of the ITA genotype clustered separately from vaccine strains and from other IBDV reference strains, either classic or very virulent. In order to obtain a more exhaustive molecular characterization of the IBDV ITA genotype and speculate on its origin, genome sequencing of the field isolate IBDV/Italy/1829/2011, previously assigned to the ITA genotype, was performed, and the sequences obtained were compared to the currently available corresponding sequences...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053793/2017-infectious-diseases-society-of-america-infectious-diarrhea-guidelines-a-view-from-the-clinical-laboratory
#6
Ferric C Fang, Robin Patel
No abstract text is available yet for this article.
October 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29053792/2017-infectious-diseases-society-of-america-clinical-practice-guidelines-for-the-diagnosis-and-management-of-infectious-diarrhea
#7
Andi L Shane, Rajal K Mody, John A Crump, Phillip I Tarr, Theodore S Steiner, Karen Kotloff, Joanne M Langley, Christine Wanke, Cirle Alcantara Warren, Allen C Cheng, Joseph Cantey, Larry K Pickering
These guidelines are intended for use by healthcare professionals who care for children and adults with suspected or confirmed infectious diarrhea. They are not intended to replace physician judgement regarding specific patients or clinical or public health situations. This document does not provide detailed recommendations on infection prevention and control aspects related to infectious diarrhea.
October 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29053777/movement-disorders-with-neuronal-antibodies-syndromic-approach-genetic-parallels-and-pathophysiology
#8
Bettina Balint, Angela Vincent, Hans-Michael Meinck, Sarosh R Irani, Kailash P Bhatia
Movement disorders are a prominent and common feature in many autoantibody-associated neurological diseases, a group of potentially treatable conditions that can mimic infectious, metabolic or neurodegenerative disease. Certain movement disorders are likely to associate with certain autoantibodies; for example, the characteristic dyskinesias, chorea and dystonia associated with NMDAR antibodies, stiff person spectrum disorders with GAD, glycine receptor, amphiphysin or DPPX antibodies, specific paroxysmal dystonias with LGI1 antibodies, and cerebellar ataxia with various anti-neuronal antibodies...
September 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053044/superior-ophthalmic-vein-thrombosis-a-rare-complication-of-graves-orbitopathy
#9
Dante Sorrentino, Kenneth J Taubenslag, Lance M Bodily, Katherine Duncan, Tonya Stefko, Jenny Y Yu
Superior ophthalmic vein thrombosis is a rare, life- and sight-threatening complication of both infectious and inflammatory orbital disease as well as hypercoagulable state. Only one case of superior ophthalmic vein thrombosis due to thyroid eye disease has been reported in the literature. This article describes the diagnosis and management of a case of superior ophthalmic vein thrombosis due to Graves' orbitopathy. Early diagnosis is critical to facilitate timely therapeutic intervention. Superior ophthalmic vein thrombosis should be considered in the differential diagnosis of acute on chronic proptosis in the setting of Graves' orbitopathy, and may represent and under-recognized and under-diagnosed clinical entity...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29051342/-68-ga-nota-functionalized-ubiquicidin-cytotoxicity-biodistribution-radiation-dosimetry-and-first-in-human-positron-emission-tomography-computed-tomography-imaging-of-infections
#10
Thomas Ebenhan, Mike Sathekge, Thabo Lenagana, Michel Koole, Olivier Gheysens, Thavendran Govender, Jan R Zeevaart
Ubiquicidin is an antimicrobial peptide (AMP) with great potential for nuclear imaging of infectious diseases as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) to allow complexation to Gallium-68 ((68)Ga-NOTA-UBI). We herein assess the cytotoxicity, radiation dosimetry for (68)Ga-NOTA-UBI and a first-in-human evaluation to diagnose infectious processes. Methods: Cytotoxicity was evaluated in green monkey kidney epithelial (Vero) cells and MT-4 leucocytes...
October 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29050810/how-to-not-detonate-the-bomb-the-case-of-the-italian-national-health-service
#11
G La Torre, A Federici
Why is Italy one of the world's highest ranked for ability and quality of healthcare in relationship to the resources invested? The last decade has been characterized by many Italian Regions with Recovery Plans, whose main focus was on short-term issues with a high impact on healthcare costs. Italy is now leaving this phase and at the regional level there will be an increase of new hirings in the healthcare sectors, as stated by the Ministry of Health. There is a large amount of scientific literature that supports the role of factors such as lifestyles, diet and genetics as the base of population health...
October 16, 2017: Public Health
https://www.readbyqxmd.com/read/29050183/-the-diagnostic-investigations-should-be-efficient-for-patients-with-uveitis
#12
M F Zhang
Uveitis is a common and etiologically complex disease. The diagnosis of uveitis is mainly based on clinical findings, and no ancillary test is needed for diagnosis of the most common uveitis entities in China. Ancillary tests, however, are needed to identify the underlying cause when the clinical presentation points to some specific disease entity, and when infectious uveitis or masquerade syndrome is suspected. A variety of ophthalmic imaging techniques and laboratory tests analyzing blood or intraocular fluid are currently available for etiological identification in uveitis as well as for disease follow-up...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050027/new-preventive-approaches-part-ii-role-of-dentin-biomodifiers-in-caries-progression
#13
Ana K Bedran-Russo, Camila A Zamperini
Dental caries is the most prevalent infectious chronic disease in children and adults. With a globally aging population, new demands in the management of dental caries are awakened by the rampant increase in the incidence of dental root caries. Like crown caries, root caries requires bacterial driven tissue demineralization followed by the degradation of the extracellular dentin matrix. Due to the complex composition and ultrastructure, preventive strategies targeting the mineral phase of dentin are insufficient for managing the prevention and progression of root caries...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049916/immune-cell-type-fingerprints-at-the-basis-of-outcome-diversity-of-human-infection
#14
REVIEW
Shelly Hen-Avivi, Roi Avraham
Despite the availability of antibiotics and immunization, infectious diseases remain a major cause of malignancy and death worldwide. Yet, it is well documented that for most infectious agents, clinical disease develops in only a small minority of infected individuals. There is, in fact, great heterogeneity in infection outcome, from complete clearance of the pathogen to severe illness. Understanding this variation remains elusive, despite its great potential to equip us with new tools for the treatment of infectious diseases...
October 16, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29049371/combining-epidemiology-with-basic-biology-of-sand-flies-parasites-and-hosts-to-inform-leishmaniasis-transmission-dynamics-and-control
#15
REVIEW
Orin Courtenay, Nathan C Peters, Matthew E Rogers, Caryn Bern
Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The parasite manipulates the sand fly via production of promastigote secretory gel (PSG), leading to the "blocked sand fly" phenotype, persistent feeding attempts, and feeding on multiple hosts. PSG is injected into the mammalian host with the parasite and promotes the establishment of infection...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29049319/clinical-outcome-and-prognostic-factors-associated-with-invasive-pulmonary-aspergillosis-an-11-year-follow-up-report-from-taiwan
#16
Kuo-Shao Sun, Ching-Fang Tsai, Solomon Chih-Cheng Chen, Wan-Chun Huang
BACKGROUND: Invasive pulmonary aspergillosis (IPA) has high mortality rate but prognostic factors are not well established. The aim of our study was to evaluate the trend in in-hospital mortality over a period of 11 years and identify factors affecting the clinical outcomes of patients with IPA. METHOD: We conducted a nationwide inpatient population study using data from the Taiwan National Health Insurance Research Database. A total of 407 IPA patients from 2002 to 2012 were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/29049256/learning-from-clinical-experience-with-necrotizing-fasciitis-treatment-and-management
#17
Yukun Liu, Ke Guo, Jiaming Sun
GENERAL PURPOSE: To provide information about necrotizing fasciitis (NF), how to recognize it, and evidence-based treatment. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Necrotizing fasciitis is a threatening, rapidly progressive, infectious disease of the soft tissue...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29049213/clinical-characteristics-and-prognostic-risk-factors-of-healthcare-associated-pneumonia-in-a-korean-tertiary-teaching-hospital
#18
June H Ahn, Kwan H Lee, Jin H Chung, Kyeong-Cheol Shin, Choong K Lee, Hyun Jung Kim, Eun Young Choi
The 2016 American Thoracic Society and Infectious Diseases Society of America (ATS/IDSA) guidelines removed the concept of healthcare-associated pneumonia (HCAP). We examined whether the 2016 ATS/IDSA guidelines are applicable in Korea.We conducted a retrospective, observational study of pneumonia patients who were hospitalized at a tertiary teaching hospital from March 2012 to February 2014. Identified pathogens that were not susceptible to β-lactams, macrolides, and fluoroquinolones were defined as community-acquired pneumonia drug-resistant pathogens (CAP-DRPs)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048275/comparison-of-in-house-igm-and-igg-elisas-for-the-serodiagnosis-of-melioidosis-in-malaysia
#19
Shirley Yi Fen Hii, Noor Azila Ali, Norazah Ahmad, Fairuz Amran
Melioidosis is an endemic infectious disease in Southeast Asia and northern Australia, caused by Burkholderia pseudomallei. However, the incidence rate in Malaysia is not well documented. The high mortality rate and broad range of clinical presentations require rapid and accurate diagnosis for appropriate treatment. This study compared the efficacy of in-house IgM and IgG ELISA methods using a local B. pseudomallei strain. The diagnostic accuracy of the in-house IgG ELISA was better than that of the IgM ELISA: sensitivity (IgG: 84...
October 19, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29047391/report-of-a-case-combining%C3%A2-solitary-peutz-jeghers-polyp-colitis-cystica-profunda-and-high-grade-dysplasia-of-the-epithelium%C3%A2-of-the-colon
#20
Alexandros Papalampros, Michail G Vailas, Maria Sotiropoulou, Efstratia Baili, Spiridon Davakis, Demetrios Moris, Evangelos Felekouras, Ioanna Deladetsima
BACKGROUND: Colitis cystica profunda is a rare nonneoplastic disease defined by the presence of intramural cysts that contain mucus, usually situated in the rectosigmoid area, which can mimic various malignant lesions and polyps. Its etiology still remains not fully elucidated, and several mechanisms such as congenital, post-traumatic, and infectious have been implicated in the development of this rare entity. CASE PRESENTATION: Herein, we describe a unique case of colitis cystica profunda in the setting of Peutz-Jeghers-type polyp of the sigmoid colon, associated with high-grade dysplasia of the overlying epithelium in a 48-year-old female patient, who presented to the emergency room with signs of intestinal obstruction...
October 18, 2017: World Journal of Surgical Oncology
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