keyword
MENU ▼
Read by QxMD icon Read
search

Clinical Infectious Diseases

keyword
https://www.readbyqxmd.com/read/29684754/increases-in-helminth-induced-il-21-protein-levels-disappear-upon-sample-freezing
#1
Anupama Ariyaratne, Edina K Szabo, Joel Bowron, Constance A M Finney
IL-21 is a much studied cytokine that has been implicated in the regulation of TH1, TH2, TH17 and regulatory immune responses; its signalling is a promising therapeutic target for autoimmune, inflammatory and infectious diseases. Despite its biological importance, measuring IL-21 reliably has proved difficult. ELISAs are commonly used to measure cytokines in various biological samples. However, results obtained are only as good as the quality of the sample. Here, we show that when using fresh samples, a significant increase in IL-21 was measured in the intestinal homogenate of mice infected with the intestinal worm Heligmosomoides polygyrus...
April 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29684649/china-s-capacity-of-hospitals-to-deal-with-infectious-diseases-in-the-context-of-climate-change
#2
Michael Xiaoliang Tong, Alana Hansen, Scott Hanson-Easey, Jianjun Xiang, Scott Cameron, Qiyong Liu, Xiaobo Liu, Yehuan Sun, Philip Weinstein, Gil-Soo Han, Peng Bi
OBJECTIVES: Infectious diseases are a major cause of morbidity and mortality in China. The capacity of hospitals to deal with the challenge from emerging and re-emerging infectious diseases due to climate change is of great importance to population health. This study aimed to explore the capacity of hospitals in China to deal with such challenges. METHODS: A cross-sectional questionnaire survey was utilized to gauge information regarding capacity of hospitals to deal with infectious diseases in the context of climate change among 611 clinical professionals whose roles pertained to infectious disease diagnosis, treatment and management in Anhui Province of China...
April 16, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684319/lipid-accumulation-product-index-in-hiv-infected-patients-a-marker-of-cardiovascular-risk
#3
Milena Maria Moreira Guimarães, Dirceu Bartolomeu Greco, Allyson Nogueira Moreira, Nathalia Sernizon Guimarães, Cláudia Maria Vilas Freire, Bruna Guimarães Rolfs, Lucas José de Campos Machado
The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels...
April 20, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29684015/cryosurgery-for-the-treatment-of-cutaneous-sporotrichosis-in-four-pregnant-women
#4
Vivian Fichman, Antonio Carlos Francesconi do Valle, Priscila Marques de Macedo, Dayvison Francis Saraiva Freitas, Manoel Marques Evangelista de Oliveira, Rodrigo Almeida-Paes, Maria Clara Gutierrez-Galhardo
BACKGROUND: Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group...
April 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29683153/paper-based-nucleic-acid-amplification-tests-for-point-of-care-diagnostics
#5
REVIEW
Navjot Kaur, Bhushan J Toley
There has been a recent resurgence in the use of paper as a substrate for developing point-of-care medical diagnostic tests, possibly triggered by expiring patents published in the 1990s. A hallmark of this resurgence has been the development of advanced shapes and structures made from paper to conduct multi-step fluidic operations using the wicking action of porous materials. Such devices indicate a distinct improvement over lateral flow immunoassays, which are restricted to conducting one-step operations...
April 23, 2018: Analyst
https://www.readbyqxmd.com/read/29682256/identification-of-oral-risk-factors-for-chronic-graft-versus-host-disease-in-haematological-patients-who-underwent-allogeneic-haematopoietic-stem-cell-transplantation
#6
A Picardi, M Miranda, F Liciani, G Paterno, W Arcese, P Bollero
Objective: The aim of this prospective observational study was to identify local risk factors for the development of clinical manifestations of oral chronic Graft versus Host Disease (cGvHD) in a cohort of patients affected by haematological malignant diseases who underwent allogeneic haematopoietic stem cell transplantation (HSCT). Materials and methods: In the context of an active collaboration between the Rome Transplant Network of the Hematology and the Oral Pathology Division at "Policlinico Tor Vergata", in Rome, 47 haematological patients were included in this trial based on a systematic dental screening and follow-up protocol...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#7
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29678233/selection-of-avibacterium-paragallinarum-page-serovar-b-strains-for-an-infectious-coryza-vaccine
#8
Huiling Sun, Sanlei Xie, Xiaofei Li, Fuzhou Xu, Yi Li, Charlotte E Boucher, Xiaoling Chen
Infectious coryza is an important respiratory disease of chickens around the world and is caused by Avibacterium paragallinarum. Among the three Page serovars currently recognized for this bacterium, serovar B is a major circulating serovar in China nowadays. The cross-protection ability of the Page serovar B reference strain (0222) and five local isolates was evaluated by a vaccination-challenge trial in SPF chickens. The clinical signs seen in control birds challenged by strain 0222 and isolate HB 01 were significantly different, with isolate HB 01 giving more severe clinical signs...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678144/interferon-alpha-as-antiviral-therapy-in-chronic-active-epstein-barr-virus-disease-with-interstitial-pneumonia-case-report
#9
Jacek Roliński, Ewelina Grywalska, Aleksandra Pyzik, Michał Dzik, Violetta Opoka-Winiarska, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Piotr Grabarczyk, Elżbieta Starosławska
BACKGROUND: Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is defined as a severe, progressive lymphoproliferative disorder associated with active EBV infection persisting longer than 6 months and developing in patients without recognised immunodeficiency. Rarely, interstitial pneumonitis (IP) occurs as a serious complication in CAEBV patients. The standard therapeutic regimen for IP in CAEBV has not yet been defined. Although interferon alpha (IFN-alpha) is known to suppress viral DNA replication by affecting its basal promoter activation process, it is rarely used in CAEBV patients...
April 20, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29677960/electronic-health-records-from-the-management-of-patients-to-the-research-use-of-clinical-data
#10
Barbara Giannini, Francesco Curtaz, Filippo Del Puente, Antonio Di Biagio, Mauro Giacomini
Paper based medical records are still widespread in Italian hospitals and the workflow to manage outpatients' visits is critical. Too many isolated software programs coexist in hospital wards and cause confusion and disorganization. A computerized medical record that unifies all the data contained in the various applications should be of fundamental importance in supporting physician's daily activities. Moreover, with the digital clinical record, data can be re-used for research purposes. The aim of this project is to create a web application for the management of outpatient visits to the Infectious Diseases Unit of the San Martino Hospital in Genoa...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677189/progress-in-the-pharmacological-treatment-of-human-cystic-and-alveolar-echinococcosis-compounds-and-therapeutic-targets
#11
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29675489/female-genital-tuberculosis-cases-with-distinct-clinical-symptoms-four-case-reports
#12
Gonul Aslan, Mahmut Ulger, Seda Tezcan Ulger, Huseyin Durukan, Faik Gurkan Yazici, Gurol Emekdas
Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Genital TB (GTB) is a form of extrapulmonary TB that occurs more frequently in women, in whom it classically presents in association with menstrual irregularity, pregnancy loss and short and long-term sequelae especially infertility in infected women. Patients with GTB are usually young women diagnosed during workup for infertility. GTB is rare in postmenopausal women and responsible for only approximately 1% of postmenopausal bleeding...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675078/novel-rab3gap1-mutations-causing-warburg-micro-syndrome-in-two-italian-sisters
#13
Pasquale Loiudice, Debora Napoli, Maria Cristina Ragone, Marco Nardi, Giamberto Casini
This report details two novel RAB3GAP1 mutations causing Warburg Micro syndrome, a rare autosomal recessive disorder characterized by multiple organ abnormalities involving the ocular, nervous, and endocrine systems. Two Italian sisters were referred to our department for the assessment of congenital bilateral cataracts. They also presented with microphthalmia, postnatal microcephaly, severe developmental delay, and hypotony. Perinatal investigations were negative for any toxins or infectious diseases during pregnancy, including toxoplasmosis, rubella, cytomegalovirus, and herpes virus...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29672953/astragalus-polysaccharides-exerts-anti-infective-activity-by-inducing-human-cathelicidin-antimicrobial-peptide-ll-37-in-respiratory-epithelial-cells
#14
Lin Zhao, Shuai Tan, Hai Zhang, Peng Liu, Yu-Zhu Tan, Jia-Chuan Li, Da Jia, Xiao-Fei Shen
Astragalus polysaccharides (APS), one of the major active components in Astragalus membranaceus, is an effective immunomodulator used in the treatment of immunological diseases in China. However, the anti-infective action and mechanism of APS is not fully known. In the present study, we found that APS induced the expression of human cathelicidin antimicrobial peptide LL-37, a key host anti-infective molecule, in both mRNA and protein levels in respiratory epithelial cells HBE16 and A549. Furthermore, the lysate and supernatant from APS-treated HBE16 cells both exhibited an obvious antibacterial action, which was partially neutralizated by LL-37 monoclonal antibody...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29670861/the-cynomolgus-macaque-natural-history-model-of-pneumonic-tularemia-for-predicting-clinical-efficacy-under-the-animal-rule
#15
Tina Guina, Lynda L Lanning, Kristian S Omland, Mark S Williams, Larry A Wolfraim, Stephen P Heyse, Christopher R Houchens, Patrick Sanz, Judith A Hewitt
Francisella tularensis is a highly infectious Gram-negative bacterium that is the etiologic agent of tularemia in animals and humans and a Tier 1 select agent. The natural incidence of pneumonic tularemia worldwide is very low; therefore, it is not feasible to conduct clinical efficacy testing of tularemia medical countermeasures (MCM) in human populations. Development and licensure of tularemia therapeutics and vaccines need to occur under the Food and Drug Administration's (FDA's) Animal Rule under which efficacy studies are conducted in well-characterized animal models that reflect the pathophysiology of human disease...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29670768/assessment-of-anti-tb-drug-nonadherence-and-associated-factors-among-tb-patients-attending-tb-clinics-in-arba-minch-governmental-health-institutions-southern-ethiopia
#16
Addisu Alemayehu Gube, Megbaru Debalkie, Kalid Seid, Kiberalem Bisete, Asfaw Mengesha, Abubeker Zeynu, Freselam Shimelis, Feleke Gebremeskel
Background: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis . Nonadherence to anti-TB treatment may result in the emergence of multidrug-resistant TB, prolonged infectiousness, and poor tuberculosis treatment outcomes. Ethiopia is one of the seven countries that reported lower rates of treatment success (84%). This study assessed anti-TB drug nonadherence and associated factors among TB patients in Arba Minch governmental health institutions...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29670670/tgf-%C3%AE-polymorphisms-are-a-risk-factor-for-chagas-disease
#17
Roberto Rodrigues Ferreira, Fabiana da Silva Madeira, Gabriel Farias Alves, Mayara da Costa Chambela, Eduardo de Oliveira Vaz Curvo, Aline Dos Santos Moreira, Renata Almeida de Sá, Leila Mendonça-Lima, Pedro Hernan Cabello, Sabine Bailly, Jean-Jacques Feige, Tania Cremonini Araujo-Jorge, Roberto Magalhães Saraiva, Mariana Caldas Waghabi
Transforming growth factor β 1 (TGF- β 1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF- β 1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (-800 G>A, -509 C>T, +10 T>C, +25 G>C, and +263 C>T)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29670631/x-linked-lymphoproliferative-disease-type-1-a-clinical-and-molecular-perspective
#18
REVIEW
Neelam Panchal, Claire Booth, Jennifer L Cannons, Pamela L Schwartzberg
X-linked lymphoproliferative disease (XLP) was first described in the 1970s as a fatal lymphoproliferative syndrome associated with infection with Epstein-Barr virus (EBV). Features include hemophagocytic lymphohistiocytosis (HLH), lymphomas, and dysgammaglobulinemias. Molecular cloning of the causative gene, SH2D1A , has provided insight into the nature of disease, as well as helped characterize multiple features of normal immune cell function. Although XLP type 1 (XLP1) provides an example of a primary immunodeficiency in which patients have problems clearing primarily one infectious agent, it is clear that XLP1 is also a disease of severe immune dysregulation, even independent of EBV infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670404/evaluation-of-vancomycin-therapy-in-the-adult-icus-of-a-teaching-hospital-in-southern-iran
#19
Afsaneh Vazin, Motahare Mahi Birjand, Masoud Darake
Background: Vancomycin resistance in intensive care units (ICUs) accounts for significant morbidity and excess costs. The objective of the present study was to determine the appropriateness of vancomycin use in the various ICUs of Nemazee Hospital, Shiraz, Iran. Methods: This prospective study was performed on 95 critically ill patients (48 males and 47 females) who were treated with vancomycin for at least 3 subsequent doses in 6 ICUs during 12 months. Required demographic, clinical, and paraclinical data were collected by a pharmacist...
2018: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/29669423/using-a-retention-in-care-protocol-to-promote-positive-health-and-systems-related-outcomes
#20
Alfred A Larbi, Freya Spielberg, Nnemdi Kamanu Elias, Erin Athey, Ngozi Ogbuawa, Nancy Murphy
People living with HIV can experience the full benefits of retention when they are continuously engaged in care. Continuous engagement in care promotes improved adherence to ART and positive health outcomes. An infectious disease clinic has implemented a protocol to primarily improve patient retention. The retrospective, facility-based, costing study took place in an infectious disease clinic in Washington DC. Retention was defined in two ways and over a 12-month period. Micro-costing direct measurement methods were used to collect unit costs in time series...
April 18, 2018: AIDS Care
keyword
keyword
31096
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"