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https://www.readbyqxmd.com/read/29683859/correlation-with-lymphocyte-infiltration-but-lack-of-prognostic-significance-of-meca-79-positive-high-endothelial-venules-in-primary-malignant-melanoma
#1
Tímea Sebestyén, Anita Mohos, Gabriella Liszkay, Beáta Somlai, István Gaudi, Andrea Ladányi
High endothelial venules (HEVs) are specialized vessels in lymphoid organs, supporting lymphocyte trafficking from the blood. As the presence of these vessels was described recently in tumors, it was proposed that they could facilitate the development of antitumor immune response, resulting in improved prognosis. The aim of our study was to analyze the correlation of the density of HEVs with that of the different immune cell types as well as with the clinicopathologic parameters and the disease outcomes in patients with cutaneous melanoma...
April 20, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29680694/hepatitis-e-virus-in-lettuce-and-water-samples-a-method-comparison-study
#2
Walter Randazzo, Andrea Vásquez-García, Maria A Bracho, María Jesús Alcaraz, Rosa Aznar, Gloria Sánchez
The hepatitis E virus (HEV), which is an increasing cause of acute viral hepatitis in Europe, is a zoonotic virus that is mainly transmitted through contaminated water, consumption of raw or undercooked meat from pigs or wild boar, blood transfusion, and organ transplantation. Although the role of HEV transmission through contaminated produce has not been confirmed, the presence of HEV has been reported in irrigation waters and in vegetables. The present study used a World Health Organization (WHO) international standard and clinical samples to evaluate the performance characteristics of three RT-qPCR assays for detection and quantification of HEV...
April 4, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29676758/learning-from-water-treatment-and-hygiene-interventions-in-response-to-a-hepatitis-e-outbreak-in-an-open-setting-in-chad
#3
Alexander Spina, David Beversluis, Andrea Irwin, Alexandra Chen, Jean Noel Nassariman, Abdelkhadir Ahamat, Idriss Noh, Jan Oosterloo, Prince Alfani, Sibylle Sang, Annick Lenglet, Dawn Louise Taylor
In September 2016, Médecins Sans Frontières responded to a hepatitis E (HEV) outbreak in Chad by implementing water treatment and hygiene interventions. To evaluate the coverage and use of these interventions, we conducted a cross-sectional study in the community. Our results showed that 99% of households interviewed had received a hygiene kit from us, aimed at improving water handling practice and personal hygiene and almost all respondents had heard messages about preventing jaundice and handwashing. Acceptance of chlorination of drinking water was also very high, although at the time of interview, we were only able to measure a safe free residual chlorine level (free chlorine residual (FRC) ≥0...
April 2018: Journal of Water and Health
https://www.readbyqxmd.com/read/29675889/acute-liver-failure-caused-by-hepatitis-e-virus-genotype-3-and-4-a-systematic-review-and-pooled-analysis
#4
Samir Haffar, Shalimar, Ravinder Jeet Kaur, Zhen Wang, Larry Prokop, M Hassan Murad, Fateh Bazerbachi
BACKGROUND: Acute liver failure (ALF) caused by hepatitis E virus (HEV) genotype 3 and 4 has been rarely described. Due to the presence of a short golden therapeutic window in patients with viral ALF from other causes, it is possible that early recognition and treatment might reduce the morbidity and mortality. We performed a systematicac review and pooled analysis of ALF caused by HEV genotype 3 and 4. METHODS: Two reviewers appraised studies after searching multiple databases on June 12th , 2017...
April 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29674549/a-world-health-organization-human-hepatitis-e-virus-reference-strain-related-to-similar-strains-isolated-from-rabbits
#5
Marco Kaiser, Déborah Delaune, Olivier Chazouillères, Johannes Blümel, Anne-Marie Roque-Afonso, Sally A Baylis
We report here the genome sequence of a hepatitis E virus (HEV) strain from a chronically infected immunodeficient patient. Full-length sequence analysis revealed a distinct HEV strain, of a tentative new subgenotype, clustering with viruses from rabbits. It is a World Health Organization reference strain for validation of nucleic acid testing.
April 19, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29670408/acute-hepatitis-e-in-a-renal-transplantation-recipient-a-case-report
#6
Mitsutoshi Shindo, Hiroaki Takemae, Takafumi Kubo, Masatsugu Soeno, Tetsuo Ando, Yoshiyuki Morishita
Hepatitis E is caused by infection with the hepatitis E virus (HEV). HEV is transmitted orally via HEV-contaminated food or drink. Hepatitis E usually shows mild symptoms and is self-limiting in the general population; however, it may progress to chronic hepatitis in immunosuppressed patients such as recipients of organ transplantation. However, a few cases of acute hepatitis E have been reported in organ transplantation recipients. We herein report a case of acute hepatitis E in a 31-year-old male renal transplant recipient...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29669922/origin-antigenicity-and-function-of-a-secreted-form-of-orf2-in-hepatitis-e-virus-infection
#7
Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M Walker, Ningshao Xia, Zizheng Zheng, Zongdi Feng
The enterically transmitted hepatitis E virus (HEV) adopts a unique strategy to exit cells by cloaking its capsid (encoded by the viral ORF2 gene) and circulating in the blood as "quasi-enveloped" particles. However, recent evidence suggests that the majority of the ORF2 protein present in the patient serum and supernatants of HEV-infected cell culture exists in a free form and is not associated with virus particles. The origin and biological functions of this secreted form of ORF2 (ORF2S ) are unknown...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29669835/characterization-of-three-novel-linear-neutralizing-b-cell-epitopes-in-the-capsid-protein-of-swine-hepatitis-e-virus
#8
Yiyang Chen, Baoyuan Liu, Yani Sun, Huixia Li, Taofeng Du, Yuchen Nan, Julian A Hiscox, En-Min Zhou, Qin Zhao
Hepatitis E virus (HEV) causes liver disease in humans and is thought to be a zoonotic infection with domestic animals being a reservoir including swine and rabbits. One of the proteins encoded by the virus is the capsid protein. This is likely the major immune-dominant protein and a target for vaccination. Four monoclonal antibodies (MAbs); three novel; 1E4, 2C7, 2G9, and one previously characterized (1B5), were evaluated for binding to the capsid protein from genotype 4 (swine) hepatitis E virus (HEV). The results indicated that 625 DFCP628 , 458 PSRPF462 , and 407 EPTV410 peptides on the capsid protein comprised minimal amino acid sequence motifs recognized by 1E4, 2C7, and 2G9, respectively...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29669284/manifold-roles-of-ccr7-and-its-ligands-in-the-induction-and-maintenance-of-bronchus-associated-lymphoid-tissue
#9
Henrike Fleige, Berislav Bosnjak, Marc Permanyer, Jasmin Ristenpart, Anja Bubke, Stefanie Willenzon, Gerd Sutter, Sanjiv A Luther, Reinhold Förster
The processes underlying the development and maintenance of tertiary lymphoid organs are incompletely understood. Using a Ccr7 knockout/knockin approach, we show that spontaneous bronchus-associated lymphoid tissue (BALT) formation can be caused by CCR7-mediated migration defects of dendritic cells (DCs) in the lung. Plt/plt mice that lack the CCR7 ligands CCL19 and CCL21-serine do not form BALT spontaneously because lung-expressed CCL21-leucine presumably suffices to maintain steady-state DC egress. However, plt/plt mice are highly susceptible to modified vaccinia virus infection, showing enhanced recruitment of immune cells as well as alterations in CCR7-ligand-mediated lymphocyte egress from the lungs, leading to dramatically enhanced BALT...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29665156/ribavirin-therapy-of-hepatitis-e-infection-may-cause-hyporegenerative-anemia-in-pediatric-renal-transplant-patients
#10
Verena Klämbt, Marcus Panning, Maximilian Seidl, Karsten Häffner, Martin Pohl
HEV infection can lead to chronic hepatitis in immunosuppressed patients; extrahepatic manifestations are rarely seen. Here, we report a 13-year-old renal transplant patient with chronic hepatitis E and renal involvement. Ribavirin therapy led to temporary virus clearance and amelioration of kidney function. However, ribavirin therapy caused severe hyporegenerative anemia, which has so far only been reported in patients treated with a combination of ribavirin and interferon alpha.
April 17, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29663452/seroprevalence-and-risk-factors-of-hepatitis-e-virus-infection-among-pregnant-women-attending-antenatal-care-in-health-facilities-of-tigray-northern-ethiopia
#11
Selam Niguse, Haftamu Hailekiros, Gerezgiher Buruh, Tadese Dejene, Nega Berhe, Tsehaye Asmelash
Existing literatures from developing countries show an increased mortality and morbidity related to hepatitis E virus during pregnancy as compared to the general population. Studies focusing on pregnant women are required for policy makers to improve maternal and child health. Therefore this study is aimed at determining the prevalence and associated risk factors of hepatitis E virus infection among pregnant women attending the health facilities of Tigray region, Northern Ethiopia. In this cross sectional study 846 pregnant women were included consecutively from April 2014 to February 2016...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29660259/hepatitis-e-seroprevalence-in-the-americas-a-systematic-review-and-meta-analysis
#12
Thomas Horvatits, Ann-Kathrin Ozga, Dirk Westhoelter, Johannes Hartl, Carolin Manthey, Marc Lütgehetmann, Geraldine Rauch, Levente Kriston, Ansgar W Lohse, Richard Bendall, Heiner Wedemeyer, Harry R Dalton, Sven Pischke
BACKGROUND & AIMS: While hepatitis E virus (HEV) infections are a relevant topic in Europe, knowledge about epidemiology of HEV infections in the USA and Latin America is still limited. Aim of this study was to estimate anti-HEV IgG seroprevalence in the Americas and to assess whether low socioeconomic status is associated with HEV exposure. METHODS: We performed a systematic review and meta-analysis. Literature search was performed in PubMed for articles published 01/1994-12/2016...
April 16, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29659194/detection-of-hepatitis-e-virus-rna-in-saliva-for-diagnosis-of-acute-infection
#13
A Rivero-Juarez, M Frias, P Lopez-Lopez, A Martinez-Peinado, M Á Risalde, T Brieva, I Machuca, Á Camacho, I García-Bocanegra, J C Gomez-Villamandos, A Rivero
Diagnosis of acute hepatitis E virus (HEV) infection is established by detection of anti-HEV IgM antibodies by ELISA or by amplification of serum viral RNA. Here, we evaluate the diagnostic value of testing HEV RNA in saliva to identify patients with acute HEV infection. Prospective proof-of-concept study including patients with acute hepatitis. Whole blood and neat saliva samples were obtained from all patients. Saliva samples were processed and analysed for HEV RNA by RT-PCR within 2 hr after collection...
April 16, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29656134/seroprevalence-and-risk-factors-of-hepatitis-e-virus-infection-in-cancer-patients-in-eastern-china
#14
Meng-Jie Bai, Na Zhou, Wei Dong, Guang-Xing Li, Wei Cong, Xing-Quan Zhu
OBJECTIVES: Hepatitis E virus (HEV) is a single-stranded RNA virus infecting a variety of animals and humans. However, little is known of HEV infection among cancer patients in China. This study provides new epidemiological data for the prevalence of co-infection of HEV in cancer patients, indicating that HEV infection is common in this group. METHODS: We recruited a total of 950 cancer patients and 950 control volunteers from Shandong Province, eastern China, to participate in our investigation...
April 12, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29656087/molecular-features-of-hepatitis-e-virus-circulation-in-environmental-and-human-samples
#15
H Fenaux, M Chassaing, S Berger, H Jeulin, A Gentilhomme, M Bensenane, J P Bronowicki, C Gantzer, I Bertrand, E Schvoerer
BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is emerging but its circulation between humans and the environment remains misunderstood. HEV ORF2 gene encodes the capsid playing a key role in viral interactions with surfaces, ORF3 products are involved in the viral cycle. Our aim was to study the molecular characteristics of ORF2 and ORF3 which could favor HEV fitness in patients and the environment. STUDY DESIGN: Samples from 69 patients with hepatitis (blood/stools), 20 urban wastewaters, 20 effluents of a pig slaughterhouse, 22 farm pigs (stools), 20 wild boars (liver/stools) were collected in North-Eastern France...
April 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29650438/hepatitis-e-virus-infection-mimicking-acute-graft-rejection-in-a-liver-transplant-recipient
#16
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29624819/use-of-s17-fragment-containing-hepatitis-e-virus-infectious-clones-in-cell-culture-experiments-the-fine-print-does-matter
#17
Siddharth Sridhar
I read with interest the work by Drave et al on the replication of hepatitis E virus (HEV) in neuronal cell lines (1). HEV is increasingly associated with a range of neurological manifestations including Guillain Barre Syndrome, neuralgic amyotrophy and encephalitis (2). Therefore, in-vitro work on this subject is timely and important. This article is protected by copyright. All rights reserved.
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29624021/construction-of-a-recombinant-baculovirus-expressing-swine-hepatitis-e-virus-orf2-and-preliminary-research-on-its-immune-effect
#18
Z Yang, Y Hu, P Yuan, Y Yang, K Wang, L Y Xie, S L Huang, J Liu, L Ran, Z H Song
In the swine hepatitis E virus (HEV), open reading frame 2 (ORF2) is rich in antigenic determinants and neutralizing epitopes that could induce immune protection. We chose the Bac-to-Bac® Baculovirus Expression System to express fragments containing the critical neutralizing antigenic sites within the HEV ORF2 protein of pigs to obtain a recombinant baculovirus. The fragment of swine HEV ORF2 region (1198-1881bp) was cloned into vector pFastBacTM. A recombinant baculovirus, rBacmid-ORF2, was obtained after transposition and transfection...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29623595/hiding-in-plain-sight-it-s-time-to-investigate-other-possible-transmission-routes-for-hepatitis-e-virus-hev-in-developed-countries
#19
REVIEW
Nicola J King, Joanne Hewitt, Anne-Marie Perchec-Merien
Historically in developed countries, reported hepatitis E cases were typically travellers returning from countries where hepatitis E virus (HEV) is endemic, but now there are increasing numbers of non-travel-related ("autochthonous") cases being reported. Data for HEV in New Zealand remain limited and the transmission routes unproven. We critically reviewed the scientific evidence supporting HEV transmission routes in other developed countries to inform how people in New Zealand may be exposed to this virus...
April 5, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29621564/past-present-and-future-of-hepatitis-e-virus-infection-zoonotic-perspectives
#20
REVIEW
Shahid Faraz Syed, Qin Zhao, Muhammad Umar, Mahmoud Alagawany, Imtiaz Ahmed Ujjan, Feroza Soomro, Nasrullah Bangulzai, Abdul Hameed Baloch, Mohamed Abd El-Hack, En-Min Zhou, Muhammad Asif Arain
The origin of hepatitis E virus (HEV) is not fully understood, but it is considered an emerging zoonotic pathogen. To date, HEV has been isolated from many animal species. The family Hepeviridae consists of two genera. The genus Orthohepevirus includes four distinct species (A, B, C, and D), each with distinct genotypes. Within the Orthohepevirus A species, HEV-1 and HEV-2 host ranges are restricted to humans, whereas genotypes 3 and 4 primarily infect a wide range of diverse animal species, in addition to being zoonotic to humans...
April 2, 2018: Microbial Pathogenesis
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