keyword
MENU ▼
Read by QxMD icon Read
search

HEV

keyword
https://www.readbyqxmd.com/read/27913223/hepatitis-e-virus-infection-beyond-the-liver
#1
REVIEW
S Pischke, J Hartl, S D Pas, A W Lohse, B C Jacobs, A A van der Eijk
Hepatitis E virus (HEV) infections are not limited to the liver but may also affect other organs. Several diseases, including Guillain-Barré syndrome, neuralgic amyotrophy, glomerulonephritis, cryoglobulinemia, pancreatitis, lymphoma, thrombopenia, meningitis, thyreoiditis and myocarditis have been observed in the context of hepatitis E. To date the definite pathophysiological links between HEV and extrahepatic manifestations are not yet established. However, it is suggested that HEV-infection might be causative based on serological studies, case series, in vitro data and animal models...
November 29, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27911040/retrospective-study-evaluating-seroprevalence-of-hepatitis-e-virus-in-blood-donors-and-in-swine-veterinarians-in-italy-2004
#2
L De Sabato, I Di Bartolo, E Montomoli, C Trombetta, F M Ruggeri, F Ostanello
Hepatitis E is an emerging viral disease in developed countries, with sporadic cases occasionally linked to the consumption of raw or undercooked pork, wild boar or deer meat. Cases due to transfusion or transplantation have also been reported. In developed countries, hepatitis E is considered a zoonosis and pig is the main reservoir. In the last few years, several studies conducted in Europe reported variable seroprevalence rates among the general population, ranging between 0.26% and 52.5%. A higher seroprevalence was described among workers who come in contact with pigs...
December 2, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27899274/systematic-identification-of-hepatitis-e-virus-orf2-interactome-reveals-that-tmem134-engages-in-orf2-mediated-nf-%C3%AE%C2%BAb-pathway
#3
Yabin Tian, Weijin Huang, Jun Yang, Zhiheng Wen, Yansheng Geng, Chenyan Zhao, Heqiu Zhang, Youchun Wang
Hepatitis E virus (HEV) is the causative agent of acute hepatitis E. Open reading frame 2 (ORF2) encodes the capsid protein of HEV, which is the main structural protein and may participate, together with the host factors, in viral entry and egress. However, it is still not clear which host proteins are involved in the interaction with ORF2 and what the functions of these ORF2-interacting proteins are. In this study, we have applied a split-ubiquitin yeast two-hybrid screening approach in combination with the pull-down and coimmunoprecipitation assays, identified and validated multiple interacting partners of ORF2 of genotype 1 and 4, which have diverse biological functions...
November 26, 2016: Virus Research
https://www.readbyqxmd.com/read/27893287/hepatitis-e-virus-in-wild-boar-in-northwest-poland-sensitivity-of-methods-of-detection
#4
Samart Dorn-In, Karin Schwaiger, Magdalena Twarużek, Jan Grajewski, Christoph Gottschalk, Manfred Gareis
In northwest Poland, 163 blood and 53 fecal samples of wild boars were collected in winter 2012/13 and 2013/14. All blood samples were tested for the presence of hepatitis E virus (HEV) ribonucleic acid (RNA) by two reverse transcription-polymerase chain reaction (RT-PCR) based methods and by anti-HEV IgG enzyme-linked immunosorbent assay (ELISA). About 17.2% of blood samples were seropositive. One-step nested RT-PCR turned out to be too insensitive (11.6% were positive). Therefore a two-step nested RT-PCR was applied where 25...
November 28, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27891729/low-prevalence-of-aichi-virus-in-molluscan-shellfish-samples-from-galicia-nw-spain
#5
Enrique Rivadulla, Miguel F Varela, Jesús L Romalde
AIM: The aim of this study was the detection and quantification of Aichi virus (AiV) in shellfish from three estuaries in Galicia, the main producer of molluscs in Europe. METHODS AND RESULTS: A total of 249 shellfish samples were analyzed using a reverse transcription-quantitative PCR (RT-qPCR) procedure. AiV was detected in 15 out of 249 (6.02%) samples. Ría de Ares-Betanzos showed the highest prevalence (11.1%), followed by Ría do Burgo (3.7%) and Ría de Vigo, (2...
November 28, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27891290/a-comparative-study-of-assay-performance-of-commercial-hepatitis-e-virus-enzyme-linked-immunosorbent-assay-kits-in-australian-blood-donor-samples
#6
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Susan L Stramer, Helen M Faddy
Hepatitis E virus (HEV) is transfusion-transmissible and therefore poses a risk to blood transfusion safety. Seroprevalence studies are useful for estimating disease burden and determining risk factors. Considerable variability in the sensitivity of HEV antibody detection assays exists. This study aimed to compare the performances of commercially available HEV enzyme-linked immunosorbent assays (ELISA) in Australian blood donor samples. Plasma samples that tested positive (n = 194) or negative (n = 200) for HEV IgG (Wantai HEV IgG ELISA) were selected...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27890632/evidence-of-genotypes-1-and-3-of-avian-hepatitis-e-virus-in-wild-birds
#7
Xinquan Zhang, Ivana Bilic, Salome Troxler, Michael Hess
Although the presence of four genotypes of avian hepatitis E virus (HEV) in chickens has been demonstrated, its natural host range is still barely known. In this study, swab samples from 626 wild birds originating from 62 bird species were investigated for HEV detection by molecular methods. The aim was to explore the cross-species infection of avian HEV and to compare the genetic diversity between strains infecting chicken and wild birds. In total, 8 positive samples from 4 different bird species (song thrush, little owl, feral pigeon and common buzzard) were identified and further confirmed by partial sequencing of ORF3...
November 25, 2016: Virus Research
https://www.readbyqxmd.com/read/27887586/hepatitis-e-virus-seroepidemiology-a-post-earthquake-study-among-blood-donors-in-nepal
#8
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Manita Rajkarnikar, Shrawan K Shrestha, Uru Thapa, Veronica C Hoad, Helen M Faddy
BACKGROUND: As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of water and poor sanitation. In industrialised nations, HEV infections are associated with travel to countries endemic for HEV, however, autochthonous infections, mainly through zoonotic transmission, are increasingly being reported. HEV can also be transmitted by blood transfusion...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27885564/hepatitis-e-virus-infection-in-patients-on-dialysis-and-in-solid-organ-transplant-recipients-in-argentina-exploring-associated-risk-factors
#9
María Belén Pisano, Domingo Balderramo, Maribel Martínez Wassaf, Martín Lotto, Yanina Carlino, Viviana Elizabeth Ré, José D Debes
Infection with hepatitis E virus (HEV) leads to acute hepatitis infection in immunocompetent hosts. HEV genotype 3 can present with high frequency and lead to chronic infection in individuals with a compromised immune system. The risk factors related to increased seroprevalence or chronicity in this population are not entirely understood. Moreover, most studies addressing risk factors for HEV in non-endemic areas come from developed areas such as North America and Europe. In this study we evaluated seroprevalence, chronicity and risk factors for HEV in 120 transplant recipients and 88 patients on dialysis in Argentina...
November 25, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27881983/high-endothelial-venules-and-lymphatic-vessels-in-tertiary-lymphoid-organs-characteristics-functions-and-regulation
#10
REVIEW
Nancy H Ruddle
High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition. HEVs bring in naïve and central memory cells and LVs transport antigen, antigen-presenting cells, and lymphocytes in and out of LNs. Tertiary lymphoid organs (TLOs) are accumulations of lymphoid and stromal cells that arise and organize at ectopic sites in response to chronic inflammation in autoimmunity, microbial infection, graft rejection, and cancer...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27881614/performance-characteristics-of-a-new-consensus-commercial-kit-for-hepatitis-d-virus-rna-viral-load-quantification
#11
Frédéric Le Gal, Samira Dziri, Athenaïs Gerber, Chakib Alloui, Zahia Ben Abdesselam, Dominique Roulot, Ségolène Brichler, Emmanuel Gordien
Hepatitis Delta virus (HDV) is responsible for fulminant hepatitis and liver failure, and accelerates evolution towards cirrhosis and hepatocellular carcinoma in hepatitis B virus-infected patients. To date treatment relies upon long-term administration of pegylated alpha-interferon with sustained virological response in 30% of the patients. Very recently, new promising anti HDV therapies have been developed and are already used in clinical trials. HDV-RNA viral load (HDVL) monitoring must be an integral part of the management of the infected-patients...
November 23, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27876615/a-novel-avian-like-hepatitis-e-virus-in-wild-aquatic-bird-little-egret-egretta-garzetta-in-hungary
#12
Gábor Reuter, Ákos Boros, Róbert Mátics, Beatrix Kapusinszky, Eric Delwart, Péter Pankovics
Hepatitis E virus (HEV), family Hepeviridae, has public health concerns because of its zoonotic potential; however, the host species spectrum, animal to animal transmissions, the natural chain of hepevirus infections and the genetic diversity of HEV in wildlife especially in birds are less known. Using random amplification and next generation sequencing technology a genetically divergent avian HEV was serendipitously identified in wild bird in Hungary. HEV RNA was detected with high faecal viral load (1.33×10(8)genomiccopies/ml) measured by real-time PCR in faecal sample from a little egret (Egretta garzetta)...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27876045/seroprevalence-of-avian-hepatitis-e-virus-and-avian-leucosis-virus-subgroup-j-in-chicken-flocks-with-hepatitis-syndrome-china
#13
Yani Sun, Taofeng Du, Baoyuan Liu, Shahid Faraz Syed, Yiyang Chen, Huixia Li, Xinjie Wang, Gaiping Zhang, En-Min Zhou, Qin Zhao
BACKGROUND: From 2014 to 2015 in China, many broiler breeder and layer hen flocks exhibited a decrease in egg production and some chickens developed hepatitis syndrome including hepatomegaly, hepatic necrosis and hemorrhage. Avian hepatitis E virus (HEV) and avian leucosis virus subgroup J (ALV-J) both cause decreasing in egg production, hepatomegaly and hepatic hemorrhage in broiler breeder and layer hens. In the study, the seroprevalence of avian HEV and ALV-J in these flocks emerging the disease from Shandong and Shaanxi provinces were investigated...
November 22, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27853931/hepatitis-e-virus-genotype-3-in-slurry-samples-from-swine-farming-activities-in-italy
#14
G La Rosa, S Della Libera, M Brambilla, C Bisaglia, G Pisani, A R Ciccaglione, R Bruni, S Taffon, M Equestre, M Iaconelli
Hepatitis E virus (HEV) is an emergent causative agent of acute hepatitis, transmitted by fecal-oral route. Infection with HEV is a global cause for morbidity and mortality throughout the world: it mainly causes large outbreaks in endemic areas and sporadic autochthonous cases in industrialized countries where HEV infections seem to be an emergent zoonotic disease. Infection of porcine livestock and its relationship with the human cases have been demonstrated. The present study describes an investigation on the prevalence and diversity of HEV in pig slurry in Italy...
November 16, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27843081/hepatitis-e-virus-emerging-from-the-shadows-in-developed-countries
#15
REVIEW
Harry R Dalton, Jerard Seghatchian
Following the discovery of HEV in the 1980s, it became apparent that HEV is endemic in a number of developing countries in Asia, Africa and Mexico. In these geographical settings HEV is spread oral faecally by HEV genotypes (gt) 1 and 2, which are obligate human pathogens. Infection occurs oro-faecally, often as a result in the breakdown of fragile sanitary infrastructure allowing drinking water supplies to become contaminated with human sewage. Hepatitis E usually causes a self-limiting hepatitis in young adults with sporadic cases and occasional dramatic outbreaks involving hundreds or thousands of cases...
November 1, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27836809/persistence-of-antibodies-acquired-by-natural-hepatitis-e-virus-infection-and-the-effects-of-vaccination
#16
Yingying Su, Shoujie Huang, Meng Guo, Jun Zhao, Huan Yu, Wengang He, Hanmin Jiang, Yijun Wang, Xuefeng Zhang, Jiaping Cai, Changlin Yang, Zhongze Wang, Fengcai Zhu, Ting Wu, Jun Zhang, NingShao Xia
OBJECTIVES: Naturally acquired anti-hepatitis E virus (HEV) immunity can protect against new HEV infections. The aim of this study was to analyze the persistence of naturally acquired anti-HEV IgG and anti-HEV IgG concentrations after vaccination. METHODS: We examined the seropositivity rates of participants included in a phase III clinical efficacy trial (67 months follow-up) for a HEV vaccine (Hecolin(®)) and predicted long-term persistence using mixed-effect models...
November 8, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27836355/exacerbation-of-hepatitis-e-virus-infection-during-anti-tnf%C3%AE-treatment
#17
Patrick Behrendt, Stefan Lüth, Werner Dammermann, Svenja Drave, Richard J P Brown, Daniel Todt, Ulrike Schnoor, Eike Steinmann, Heiner Wedemeyer, Sven Pischke, Christof Iking-Konert
Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing treatment with a TNFα-inhibitor for psoriatic arthritis despite potent anti-HEV T-cell responses. We used state-of-the-art HEV cell culture methods to test antiviral effects of different drugs and a cytokine release assay to assess HEV specific T cell immunity...
November 8, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27832041/investigation-of-liver-dysfunction-who-should-we-test-for-hepatitis-e
#18
Sebastian J Wallace, Glynn W Webb, Richie G Madden, Hugh C Dalton, Joanne Palmer, Richard T Dalton, Adam Pollard, Rhys Martin, Vasilis Panayi, Gwyn Bennett, Richard P Bendall, Harry R Dalton
AIM: Hepatitis E virus (HEV) is endemic in developed countries, but unrecognized infection is common. Many national guidelines now recommend HEV testing in patients with acute hepatitis irrespective of travel history. The biochemical definition of 'hepatitis' that best predicts HEV infection has not been established. This study aimed to determine parameters of liver biochemistry that should prompt testing for acute HEV. METHODS: This was a retrospective study of serial liver function tests (LFTs) in cases of acute HEV (n=74) and three comparator groups: common bile duct stones (CBD, n=87), drug-induced liver injury (DILI, n=69) and patients testing negative for HEV (n=530)...
November 9, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27827877/acute-hepatitis-e-two-sides-of-the-same-coin
#19
REVIEW
Johannes Hartl, Malte H Wehmeyer, Sven Pischke
The relevance of acute hepatitis E virus (HEV) infections has been underestimated for a long time. In the past, HEV infection had been interpreted falsely as a disease limited to the tropics until the relevance of autochthonous HEV infections in the Western world became overt. Due to increased awareness, the incidence of diagnosed autochthonous HEV infections (predominantly genotype 3) in industrialized countries has risen within the last decade. The main source of infections in industrialized countries seems to be infected swine meat, while infections with the tropical HEV genotypes 1 and 2 usually are mainly transmitted fecal-orally by contaminated drinking water...
November 3, 2016: Viruses
https://www.readbyqxmd.com/read/27825308/seroprevalence-of-hepatitis-e-virus-differs-in-dutch-and-first-generation-migrant-populations-in-amsterdam-the-netherlands-a-cross-sectional-study
#20
S Sadik, G G C van Rijckevorsel, M S van Rooijen, G J B Sonder, S M Bruisten
BACKGROUND: In the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands, HEV infection is suspected to be a zoonosis but HEV may also be introduced by migrants. We studied the seroprevalence of HEV among different migrants, mainly Moroccans and Turks, and compared this to that of the native Dutch population in Amsterdam, the Netherlands. METHODS: Data were obtained from a cross-sectional survey of the adult Amsterdam population performed in 2004; the Amsterdam Health Monitor...
November 8, 2016: BMC Infectious Diseases
keyword
keyword
31092
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"