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https://www.readbyqxmd.com/read/29776607/differentiation-of-equine-bone-marrow-derived-mesenchymal-stem-cells-increases-the-expression-of-immunogenic-genes
#1
Laura Barrachina, Ana Rosa Remacha, Antonio Romero, Pilar Zaragoza, Francisco José Vázquez, Clementina Rodellar
Mesenchymal stem cells (MSCs) are a promising treatment for equine musculoskeletal injuries because of their ability to regulate the inflammation and to differentiate into other cell types. Since interest in allogeneic therapy is rising, concerns about MSC immunogenicity need to be addressed. Differentiated MSCs from several species increase their expression of immunogenic molecules and induce alloresponses, but equine MSC immunogenic profile after differentiation has not been reported. Therefore, the aim of this study was to assess the gene expression of immunogenic markers in tri-lineage differentiated equine bone marrow derived MSCs (eBM-MSCs)...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29775452/the-effects-of-a-pulsed-electromagnetic-field-on-the-proliferation-and-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#2
Yukun Yin, Ping Chen, Qiang Yu, Yan Peng, ZeHao Zhu, Jing Tian
BACKGROUND A low frequency pulsed electromagnetic field (PEMF) has been confirmed to play an important role in promoting the osteogenic differentiation of human bone marrow stem cells (BMSCs). Adipose-derived stem cells (ASCs) possess some attractive characteristics for clinical application compared to BMSCs, such as abundant stem cells from lipoaspirates, faster growth, less discomfort and morbidity during surgery. ASCs can become adipocytes, osteoblasts, chondrocytes, myocytes, neurocytes, and other cell types...
May 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29771444/low-level-laser-irradiation-promotes-the-differentiation-of-bone-marrow-stromal-cells-into-osteoblasts-through-the-apn-wnt-%C3%AE-catenin-pathway
#3
R-F Zhang, Q Wang, A-A Zhang, J-G Xu, L-D Zhai, X-M Yang, X-T Liu
OBJECTIVE: The relationship between adiponectin (APN) pathway and Wnt pathway was explored through BMSCs, and the effect of low-level laser irradiation (LLLI) on bone marrow stromal cells (BMSCs) and its mechanism were further studied. MATERIALS AND METHODS: 3-week-old Sprague-Dawley (SD) rats were selected, and mesenchymal stem cells were separately cultured and purified. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to analyze cell proliferation...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29751774/changes-in-phenotype-and-differentiation-potential-of-human-mesenchymal-stem-cells-aging-in-vitro
#4
Yueh-Hsun Kevin Yang, Courtney R Ogando, Carmine Wang See, Tsui-Yun Chang, Gilda A Barabino
BACKGROUND: Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic and immunosuppressive effects. Due to the rareness and high heterogeneity of freshly isolated MSCs, extensive in-vitro passage is required to expand their populations prior to clinical use; however, senescence usually accompanies and can potentially affect MSC characteristics and functionality. Therefore, a thorough characterization of the variations in phenotype and differentiation potential of in-vitro aging MSCs must be sought...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29740803/du-zhong-eucommia-ulmoides-oliv-cortex-extract-alleviates-lead-acetate-induced-bone-loss-in-rats
#5
Shanshan Qi, Hongxing Zheng, Chen Chen, Hai Jiang
The purpose of this study was to evaluate the protective effect of Du-Zhong cortex extract (DZCE) on lead acetate-induced bone loss in rats. Forty female Sprague-Dawley rats were randomly divided into four groups: group I (control) was provided with distilled water. Group II (PbAc) received 500 ppm lead acetate in drinking water for 60 days. Group III (PbAc+DZCE) received 500 ppm lead acetate in drinking water, and given intragastric DZCE (100 mg/kg body weight) for 60 days. Group IV (DZCE) was given intragastric DZCE (100 mg/kg body weight) for 60 days...
May 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29739252/evaluation-of-the-rivastigmine-role-against-botulinum-toxin-a-induced-osteoporosis-in-albino-rats-a-biochemical-histological-and-immunohistochemical-study
#6
D M Ali, W Y Abdelzaher, Smn Abdel-Hafez
The present study aimed to evaluate the role of rivastigmine against the effect of a single unilateral botulinum toxin-A (BTX-A) injection on the bone and bone marrow of adult albino rats 4 weeks after injection. Twenty-four Wistar albino rats were divided into four equal groups: group I, which received distilled water; group II, which received rivastigmine (0.3 mg/kg daily, intraperitoneally for 4 weeks); group III, which received BTX-A (4 IU in 0.2 mL physiological saline) single dose, intramuscularly; and group IV, which received BTX-A + rivastigmine...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29731773/romidepsin-promotes-osteogenic-and-adipocytic-differentiation-of-human-mesenchymal-stem-cells-through-inhibition-of-histondeacetylase-activity
#7
Dalia Ali, Elna P Chalisserry, Muthurangan Manikandan, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M Alajez
Bone marrow mesenchymal stem cells (BMSCs) are adult multipotent stem cells that can differentiate into mesodermal lineage cells, including adipocytes and osteoblasts. However, the epigenetic mechanisms governing the lineage-specific commitment of BMSCs into adipocytes or osteoblasts are under investigation. Herein, we investigated the epigenetic effect of romidepsin, a small molecule dual inhibitor targeting HDAC1 and HDAC2 identified through an epigenetic library functional screen. BMSCs exposed to romidepsin (5 nM) exhibited enhanced adipocytic and osteoblastic differentiation...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29730394/new-insights-into-the-epigenetics-of-osteoporosis
#8
REVIEW
Jean-Guillaume Letarouilly, Odile Broux, Aline Clabaut
Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in the bone marrow compartment. The decrease in bone mass results from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The deficiency of bone cells to replace the resorpted bone can be due to a preferential differentiation of bone marrow stromal cells into adipocytes at the expense of osteoblasts. Consequently, the processes that control the differentiation of osteoclasts, osteoblasts and adipocytes play a crucial role in bone metabolism...
May 3, 2018: Genomics
https://www.readbyqxmd.com/read/29728592/the-positive-effect-of-chick-embryo-and-nutrient-mixture-on-bone-marrow-derived-mesenchymal-stem-cells-from-aging-rats
#9
Jia Ma, Yanru Guo, Jialei Hu, Yue Pan, Xia Qi, Huaxin Wang, Li Jia
The aging of many mammalian tissues is associated with loss of functional adult stem cells, especially bone marrow-derived mesenchymal stem cells (BMSCs). This study was aimed to analyze the biological effect of chick embryo (CE) and nutrient mixture (NM) on the BMSCs of aging rats. The aging rat model was established to be induced by D-galactose (500 mg/kg/d) for 90 days. Meanwhile, aging rats were fed with CE and NM in different dose manner by intragastric administration. At the end of the experimental period, serum was collected from rats and used for BMSCs culture...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29717341/strontium-ranelate-induced-anti-adipocytic-effects-are-involved-in-negative-regulation-of-autophagy-in-rat-bone-marrow-mesenchymal-stem-cells
#10
Zhenbin Xu, Xizhuang Bai
PURPOSES: Strontium ranelate (SrRN) is a novel and effective anti-osteoporotic drug used to promote bone formation and restrain bone resorption. However, studies of the effects and mechanism of SrRN on adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) remain limited. METHODS: The cytoactivity of BMMSCs was analyzed by CCK-8 and annexin V-FITC/PI kit. Then the differentiation efficiency was analyzed by Oil Red O staining and western blotting...
May 1, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29703845/mcp-1-feedback-loop-between-adipocytes-and-mesenchymal-stromal-cells-causes-fat-accumulation-and-contributes-to-hematopoietic-stem-cell-rarefaction-in-the-bone-marrow-of-diabetic-patients
#11
David Ferland-McCollough, Davide Masseli, Gaia Spinetti, Maria Sambataro, Niall Sullivan, Ashley Blom, Paolo Madeddu
Fat accumulates in bone marrow (BM) of diabetic patients. Here, we investigated the mechanisms and consequences of this phenomenon. BM-mesenchymal stromal cells (BM-MSCs) from type-2 diabetic (T2D) patients constitutively express adipogenic markers and robustly differentiate into adipocytes (ADs) upon in-vitro induction as compared with BM-MSCs from non-diabetic subjects. Moreover, T2D BM adipocytes paracrinally stimulate a transcriptional adipogenic program in BM-MSCs. Antagonism of monocyte chemoattractant protein (MCP-1), a chemokine pivotally expressed in T2D BM-ADs, prevented the TD2 BM-AD secretome from converting BM-MSCs into ADs...
April 27, 2018: Diabetes
https://www.readbyqxmd.com/read/29694926/gh-prevents-adipogenic-differentiation-of-mesenchymal-stromal-stem-cells-derived-from-human-trabecular-bone-via-canonical-wnt-signaling
#12
Simona Bolamperti, Michela Signo, Alice Spinello, GianLuigi Moro, Gianfranco Fraschini, Francesca Guidobono, Alessandro Rubinacci, Isabella Villa
The imbalance between osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. In the present study, using primary human mesenchymal stromal cells (hMSCs) isolated from trabecular bone, we assessed the possible effect of GH on hMSC differentiation potential into adipocytes. GH (5 ng/ml) significantly inhibited the lipid accumulation in hMSCs cultured for 14 days in lipogenic medium. GH decreased the expression of the adipogenic genes, CCAAT/enhancer-binding protein alpha (C/EBPα) and adiponectin (ADN) as well as the expression of two lipogenesis-related enzymes, lipoprotein lipase (LPL) and acethylCoA carboxylase (ACACA)...
April 22, 2018: Bone
https://www.readbyqxmd.com/read/29691830/stem-cells-in-osteochondral-tissue-engineering
#13
Eleonora Pintus, Matteo Baldassarri, Luca Perazzo, Simone Natali, Diego Ghinelli, Roberto Buda
Mesenchymal stem cells (MSCs) are pluripotent stem cells with the ability to differentiate into a variety of other connective tissue cells, such as chondral, bony, muscular, and tendon tissue. Bone marrow-derived MSCs are pluripotent cells that can differentiate among others into osteoblasts, adipocytes and chondrocytes.Bone marrow-derived cells may represent the future in osteochondral repair. A one-step arthroscopic technique is developed for cartilage repair, using a device to concentrate bone marrow-derived cells and collagen powder or hyaluronic acid membrane as scaffolds for cell support and platelet gel...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29673856/2-3-7-8-tetrachlorodibenzo-p-dioxin-dose-dependently-increases-bone-mass-and-decreases-marrow-adiposity-in-juvenile-mice
#14
Kelly A Fader, Rance Nault, Sandi Raehtz, Laura R McCabe, Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) agonists have been shown to regulate bone development and remodeling in a species-, ligand-, and age-specific manner, however the underlying mechanisms remain poorly understood. In this study, we characterized the effect of 0.01-30 μg/kg TCDD on the femoral morphology of male and female juvenile mice orally gavaged every 4 days for 28 days and used RNA-Seq to investigate gene expression changes associated with the resultant phenotype...
April 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29667012/bone-marrow-adipocyte-developmental-origin-and-biology
#15
REVIEW
Joanna Bukowska, Trivia Frazier, Stanley Smith, Theodore Brown, Robert Bender, Michelle McCarthy, Xiying Wu, Bruce A Bunnell, Jeffrey M Gimble
PURPOSE OF REVIEW: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. RECENT FINDINGS: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. "State of the art" methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots...
April 18, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29665934/-effect-of-regulating-ppar%C3%AE-by-mtor-signaling-on-adipogenesis-of-bone-marrow-mesenchymal-stem-cells-from-aplastic-anemia
#16
Fang Wei, Wei-Huan Zhang, Xiu-Lian Zhang, Xiao-Jing Ge, Shu-Qin Zhang
OBJECTIVE: To study the effect and mechanism of mTOR signaling on adipogenesis of bone marrow mesenchymal stem cells(BM-MSCs) from aplastic anemia (AA) patients through regulation of PPARγ. METHODS: BM-MSCs were isolated from 24 newly diagnosed AA patients and 24 healthy controls. The surface antigen expression of BM-MSCs was identified by flow cytometry. The capacity of adipogenic differentiation of BM-MSCs was determined by lipid droplets based on Oil Red O staining and by the expression of FABP4 based on Western blot...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29620466/liposarcoma-in-a-backyard-silkie-and-retrospective-summary-of-neoplasms-diagnosed-in-backyard-chickens-submitted-to-the-california-animal-health-and-food-safety-laboratory-system-2008-2017
#17
Julia Blakey, Manuela Crispo, Arthur Bickford, Simone Stoute
Liposarcomas are a malignant neoplasm of adipocytes, and are rarely diagnosed in avian species. This case report describes the evidence supporting a diagnosis of metastatic liposarcoma in a backyard silkie chicken. On September 28, 2017, a dead 3-yr-old backyard silkie chicken, with a history of unknown skin lesions involving the entire body and severe weight loss, was submitted to California Animal Health and Food Safety Laboratory System-Turlock branch for necropsy. At necropsy, raised necrotic lesions involving the majority of the skin and multiple nodules in the liver, spleen, and bone marrow were noticed...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29615915/application-of-mesenchymal-stem-cells-for-therapeutic-agent-delivery-in-anti-tumor-treatment
#18
REVIEW
Daria S Chulpanova, Kristina V Kitaeva, Leysan G Tazetdinova, Victoria James, Albert A Rizvanov, Valeriya V Solovyeva
Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circumvents the ethical concerns of working with embryonic or fetal stem cells, whilst still providing cells capable of differentiating into various cell lineages, such as adipocytes, osteocytes and chondrocytes. An important feature of MSCs is the low immunogenicity due to the lack of co-stimulatory molecules expression, meaning there is no need for immunosuppression during allogenic transplantation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29569543/effect-of-nutritional-supplement-on-bone-marrow-derived-mesenchymal-stem-cells-from-aplastic-anaemia
#19
Shihua Luo, Yinghai Chen, Lifen Zhao, Xia Qi, Xiaoyan Miao, Huimin Zhou, Li Jia
Aplastic anaemia (AA) is characterised by pancytopenia resulting from a marked reduction in haemopoietic stem cells (HSC). The regulation of haemopoiesis depends on the interaction between HSC and various cells of the bone marrow (BM) microenvironment, including BM-derived mesenchymal stromal cells (BMSC). The purpose of this study was to analyse the biological effect of nutritional supplement (NS), a dietary supplement consisting of thirty-six compounds: amino acids, nucleotides, vitamins and micronutrients on the BMSC of AA rats...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29568896/peroxisome-proliferator-activated-receptor-%C3%AE-and-its-related-pathway-in-bone-marrow-mesenchymal-stem-cell-differentiation-co-cultured-with-mechanically-stretched-ligament-fibroblasts
#20
Bing Zhao, Mengcai Hu, Huiyan Wu, Chenchen Ren, Juan Chen, Xiaodan Zhang, Shihong Cui
The occurrence of pelvic floor dysfunctional disease (PFD) is closely related with elasticity, toughness, and functional changes of the connective tissue of the pelvic support tissue. Bone marrow mesenchymal stem cells (BMSCs) have been confirmed to have the capacity to differentiate into a variety of cell types such as osteoblasts, chondroblasts, adipocytes and fibroblasts. Therefore, BMSCs have the potential to improve the clinical outcomes for PFD. Peroxisome proliferator-activated receptor-γ (PPAR-γ), a ligand activated transcription factor, has acquired a great deal of attention as it is involved in the fibrosis and cell differentiation...
March 20, 2018: International Journal of Molecular Medicine
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